-- dump date   	20140619_134732
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
444177000001	Replication-relaxation; Region: Replic_Relax; pfam13814
444177000002	Tetrahydromethanopterin S-methyltransferase, subunit E; Region: MtrE; cl01675
444177000003	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
444177000004	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
444177000005	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
444177000006	RNA binding site [nucleotide binding]; other site
444177000007	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
444177000008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
444177000009	LabA_like proteins; Region: LabA_like; cd06167
444177000010	putative metal binding site [ion binding]; other site
444177000011	Uncharacterized conserved protein [Function unknown]; Region: COG1432
444177000012	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
444177000013	CHC2 zinc finger; Region: zf-CHC2; cl17510
444177000014	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
444177000015	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
444177000016	dimer interface [polypeptide binding]; other site
444177000017	ssDNA binding site [nucleotide binding]; other site
444177000018	tetramer (dimer of dimers) interface [polypeptide binding]; other site
444177000019	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
444177000020	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
444177000021	dimer interface [polypeptide binding]; other site
444177000022	ssDNA binding site [nucleotide binding]; other site
444177000023	tetramer (dimer of dimers) interface [polypeptide binding]; other site
444177000024	DNA polymerase III subunit beta; Validated; Region: PRK05643
444177000025	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512
444177000026	putative DNA binding surface [nucleotide binding]; other site
444177000027	dimer interface [polypeptide binding]; other site
444177000028	beta-clamp/clamp loader binding surface; other site
444177000029	beta-clamp/translesion DNA polymerase binding surface; other site
444177000030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177000031	non-specific DNA binding site [nucleotide binding]; other site
444177000032	salt bridge; other site
444177000033	sequence-specific DNA binding site [nucleotide binding]; other site
444177000034	Domain of unknown function (DUF955); Region: DUF955; pfam06114
444177000035	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
444177000036	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
444177000037	Ligand Binding Site [chemical binding]; other site
444177000038	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
444177000039	active site
444177000040	NTP binding site [chemical binding]; other site
444177000041	metal binding triad [ion binding]; metal-binding site
444177000042	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
444177000043	Active Sites [active]
444177000044	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
444177000045	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
444177000046	cofactor binding site; other site
444177000047	DNA binding site [nucleotide binding]
444177000048	substrate interaction site [chemical binding]; other site
444177000049	cathepsin C-like protein; Provisional; Region: PTZ00049
444177000050	5'-3' exonuclease; Region: 53EXOc; smart00475
444177000051	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
444177000052	active site
444177000053	metal binding site 1 [ion binding]; metal-binding site
444177000054	putative 5' ssDNA interaction site; other site
444177000055	metal binding site 3; metal-binding site
444177000056	metal binding site 2 [ion binding]; metal-binding site
444177000057	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
444177000058	putative DNA binding site [nucleotide binding]; other site
444177000059	putative metal binding site [ion binding]; other site
444177000060	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
444177000061	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
444177000062	S-layer homology domain; Region: SLH; pfam00395
444177000063	S-layer homology domain; Region: SLH; pfam00395
444177000064	S-layer homology domain; Region: SLH; pfam00395
444177000065	PRTRC system protein A; Region: PRTRC_A; TIGR03735
444177000066	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
444177000067	ATP binding site [chemical binding]; other site
444177000068	substrate interface [chemical binding]; other site
444177000069	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
444177000070	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177000071	Walker A motif; other site
444177000072	ATP binding site [chemical binding]; other site
444177000073	Walker B motif; other site
444177000074	arginine finger; other site
444177000075	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
444177000076	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
444177000077	CXXC zinc finger domain; Region: zf-CXXC; pfam02008
444177000078	DNA polymerase III subunit delta'; Validated; Region: PRK08485
444177000079	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512
444177000080	putative DNA binding surface [nucleotide binding]; other site
444177000081	dimer interface [polypeptide binding]; other site
444177000082	beta-clamp/translesion DNA polymerase binding surface; other site
444177000083	beta-clamp/clamp loader binding surface; other site
444177000084	Predicted membrane protein [Function unknown]; Region: COG2311
444177000085	Domain of unknown function DUF87; Region: DUF87; pfam01935
444177000086	AAA-like domain; Region: AAA_10; pfam12846
444177000087	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
444177000088	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
444177000089	N-acetyl-D-glucosamine binding site [chemical binding]; other site
444177000090	catalytic residue [active]
444177000091	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
444177000092	Peptidase family M23; Region: Peptidase_M23; pfam01551
444177000093	Predicted membrane protein [Function unknown]; Region: COG4485
444177000094	Methyltransferase domain; Region: Methyltransf_26; pfam13659
444177000095	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
444177000096	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
444177000097	ATP binding site [chemical binding]; other site
444177000098	putative Mg++ binding site [ion binding]; other site
444177000099	nucleotide binding region [chemical binding]; other site
444177000100	helicase superfamily c-terminal domain; Region: HELICc; smart00490
444177000101	ATP-binding site [chemical binding]; other site
444177000102	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
444177000103	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
444177000104	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
444177000105	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177000106	active site
444177000107	DNA binding site [nucleotide binding]
444177000108	Int/Topo IB signature motif; other site
444177000109	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
444177000110	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
444177000111	Catalytic site; other site
444177000112	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
444177000113	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177000114	non-specific DNA binding site [nucleotide binding]; other site
444177000115	salt bridge; other site
444177000116	sequence-specific DNA binding site [nucleotide binding]; other site
444177000117	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
444177000118	Helix-turn-helix domain; Region: HTH_17; pfam12728
444177000119	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
444177000120	DNA methylase; Region: N6_N4_Mtase; cl17433
444177000121	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
444177000122	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
444177000123	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
444177000124	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
444177000125	putative active site [active]
444177000126	putative NTP binding site [chemical binding]; other site
444177000127	putative nucleic acid binding site [nucleotide binding]; other site
444177000128	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
444177000129	active site
444177000130	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
444177000131	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
444177000132	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
444177000133	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
444177000134	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
444177000135	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
444177000136	cofactor binding site; other site
444177000137	DNA binding site [nucleotide binding]
444177000138	substrate interaction site [chemical binding]; other site
444177000139	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
444177000140	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
444177000141	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636
444177000142	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
444177000143	active site
444177000144	DNA binding site [nucleotide binding]
444177000145	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
444177000146	DNA binding site [nucleotide binding]
444177000147	S-layer homology domain; Region: SLH; pfam00395
444177000148	S-layer homology domain; Region: SLH; pfam00395
444177000149	S-layer homology domain; Region: SLH; pfam00395
444177000150	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
444177000151	MPN+ (JAMM) motif; other site
444177000152	Zinc-binding site [ion binding]; other site
444177000153	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
444177000154	Staphylococcal nuclease homologue; Region: SNase; pfam00565
444177000155	Catalytic site; other site
444177000156	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
444177000157	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177000158	non-specific DNA binding site [nucleotide binding]; other site
444177000159	salt bridge; other site
444177000160	sequence-specific DNA binding site [nucleotide binding]; other site
444177000161	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
444177000162	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
444177000163	YolD-like protein; Region: YolD; pfam08863
444177000164	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
444177000165	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
444177000166	active site
444177000167	catalytic residues [active]
444177000168	DNA binding site [nucleotide binding]
444177000169	Int/Topo IB signature motif; other site
444177000170	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
444177000171	active site
444177000172	catalytic residues [active]
444177000173	DNA binding site [nucleotide binding]
444177000174	Int/Topo IB signature motif; other site
444177000175	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177000176	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177000177	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177000178	Integrase core domain; Region: rve; pfam00665
444177000179	Integrase core domain; Region: rve_3; pfam13683
444177000180	HTH-like domain; Region: HTH_21; pfam13276
444177000181	cellulose synthase A; Region: PLN02195
444177000182	Insecticidal Crystal Toxin, P42; Region: Toxin_10; pfam05431
444177000183	Insecticidal Crystal Toxin, P42; Region: Toxin_10; pfam05431
444177000184	CryBP1 protein; Region: CryBP1; pfam07029
444177000185	Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318
444177000186	Condensation domain; Region: Condensation; pfam00668
444177000187	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
444177000188	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
444177000189	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
444177000190	acyl-activating enzyme (AAE) consensus motif; other site
444177000191	AMP binding site [chemical binding]; other site
444177000192	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
444177000193	Condensation domain; Region: Condensation; pfam00668
444177000194	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
444177000195	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
444177000196	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
444177000197	acyl-activating enzyme (AAE) consensus motif; other site
444177000198	AMP binding site [chemical binding]; other site
444177000199	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
444177000200	thioester reductase domain; Region: Thioester-redct; TIGR01746
444177000201	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
444177000202	putative NAD(P) binding site [chemical binding]; other site
444177000203	active site
444177000204	putative substrate binding site [chemical binding]; other site
444177000205	Chitin binding domain; Region: Chitin_bind_3; pfam03067
444177000206	YolD-like protein; Region: YolD; pfam08863
444177000207	S-layer homology domain; Region: SLH; pfam00395
444177000208	S-layer homology domain; Region: SLH; pfam00395
444177000209	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
444177000210	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
444177000211	Walker A motif; other site
444177000212	ATP binding site [chemical binding]; other site
444177000213	Walker B motif; other site
444177000214	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
444177000215	AAA domain; Region: AAA_31; pfam13614
444177000216	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
444177000217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177000218	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
444177000219	Walker A motif; other site
444177000220	ATP binding site [chemical binding]; other site
444177000221	Walker B motif; other site
444177000222	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
444177000223	Bacterial dnaA protein helix-turn-helix domain; Region: Bac_DnaA_C; smart00760
444177000224	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
444177000225	DnaA box-binding interface [nucleotide binding]; other site
444177000226	DNA polymerase III subunit beta; Validated; Region: PRK05643
444177000227	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
444177000228	putative DNA binding surface [nucleotide binding]; other site
444177000229	dimer interface [polypeptide binding]; other site
444177000230	beta-clamp/clamp loader binding surface; other site
444177000231	beta-clamp/translesion DNA polymerase binding surface; other site
444177000232	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
444177000233	recombination protein F; Reviewed; Region: recF; PRK00064
444177000234	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
444177000235	Walker A/P-loop; other site
444177000236	ATP binding site [chemical binding]; other site
444177000237	Q-loop/lid; other site
444177000238	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177000239	ABC transporter signature motif; other site
444177000240	Walker B; other site
444177000241	D-loop; other site
444177000242	H-loop/switch region; other site
444177000243	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
444177000244	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177000245	Mg2+ binding site [ion binding]; other site
444177000246	G-X-G motif; other site
444177000247	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
444177000248	anchoring element; other site
444177000249	dimer interface [polypeptide binding]; other site
444177000250	ATP binding site [chemical binding]; other site
444177000251	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
444177000252	active site
444177000253	putative metal-binding site [ion binding]; other site
444177000254	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
444177000255	DNA gyrase subunit A; Validated; Region: PRK05560
444177000256	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
444177000257	CAP-like domain; other site
444177000258	active site
444177000259	primary dimer interface [polypeptide binding]; other site
444177000260	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
444177000261	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
444177000262	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
444177000263	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
444177000264	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
444177000265	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
444177000266	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
444177000267	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177000268	Zn2+ binding site [ion binding]; other site
444177000269	Mg2+ binding site [ion binding]; other site
444177000270	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
444177000271	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
444177000272	active site
444177000273	nucleophile elbow; other site
444177000274	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
444177000275	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
444177000276	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
444177000277	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
444177000278	active site
444177000279	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
444177000280	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
444177000281	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
444177000282	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
444177000283	active site
444177000284	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
444177000285	dimer interface [polypeptide binding]; other site
444177000286	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
444177000287	Ligand Binding Site [chemical binding]; other site
444177000288	Molecular Tunnel; other site
444177000289	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
444177000290	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177000291	DNA-binding site [nucleotide binding]; DNA binding site
444177000292	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177000293	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177000294	homodimer interface [polypeptide binding]; other site
444177000295	catalytic residue [active]
444177000296	pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180
444177000297	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
444177000298	phosphate binding site [ion binding]; other site
444177000299	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
444177000300	Glutamine amidotransferase class-I; Region: GATase; pfam00117
444177000301	predicted active site [active]
444177000302	catalytic triad [active]
444177000303	seryl-tRNA synthetase; Provisional; Region: PRK05431
444177000304	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
444177000305	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
444177000306	dimer interface [polypeptide binding]; other site
444177000307	active site
444177000308	motif 1; other site
444177000309	motif 2; other site
444177000310	motif 3; other site
444177000311	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
444177000312	nucleoside/Zn binding site; other site
444177000313	dimer interface [polypeptide binding]; other site
444177000314	catalytic motif [active]
444177000315	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177000316	dimerization interface [polypeptide binding]; other site
444177000317	putative DNA binding site [nucleotide binding]; other site
444177000318	putative Zn2+ binding site [ion binding]; other site
444177000319	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
444177000320	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
444177000321	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
444177000322	putative homodimer interface [polypeptide binding]; other site
444177000323	putative homotetramer interface [polypeptide binding]; other site
444177000324	allosteric switch controlling residues; other site
444177000325	putative metal binding site [ion binding]; other site
444177000326	putative homodimer-homodimer interface [polypeptide binding]; other site
444177000327	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
444177000328	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
444177000329	metal-binding site [ion binding]
444177000330	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
444177000331	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
444177000332	metal-binding site [ion binding]
444177000333	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
444177000334	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
444177000335	metal-binding site [ion binding]
444177000336	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
444177000337	Soluble P-type ATPase [General function prediction only]; Region: COG4087
444177000338	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
444177000339	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
444177000340	Substrate-binding site [chemical binding]; other site
444177000341	Substrate specificity [chemical binding]; other site
444177000342	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
444177000343	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
444177000344	Substrate-binding site [chemical binding]; other site
444177000345	Substrate specificity [chemical binding]; other site
444177000346	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
444177000347	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177000348	PAS domain; Region: PAS_9; pfam13426
444177000349	putative active site [active]
444177000350	heme pocket [chemical binding]; other site
444177000351	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
444177000352	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177000353	dimer interface [polypeptide binding]; other site
444177000354	putative CheW interface [polypeptide binding]; other site
444177000355	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
444177000356	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
444177000357	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
444177000358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177000359	Response regulator receiver domain; Region: Response_reg; pfam00072
444177000360	active site
444177000361	phosphorylation site [posttranslational modification]
444177000362	intermolecular recognition site; other site
444177000363	dimerization interface [polypeptide binding]; other site
444177000364	YcbB domain; Region: YcbB; pfam08664
444177000365	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
444177000366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177000367	Walker A motif; other site
444177000368	ATP binding site [chemical binding]; other site
444177000369	Walker B motif; other site
444177000370	arginine finger; other site
444177000371	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
444177000372	hypothetical protein; Validated; Region: PRK00153
444177000373	recombination protein RecR; Reviewed; Region: recR; PRK00076
444177000374	RecR protein; Region: RecR; pfam02132
444177000375	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
444177000376	putative active site [active]
444177000377	putative metal-binding site [ion binding]; other site
444177000378	tetramer interface [polypeptide binding]; other site
444177000379	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
444177000380	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
444177000381	hydrophobic ligand binding site; other site
444177000382	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
444177000383	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
444177000384	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177000385	catalytic residue [active]
444177000386	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
444177000387	thymidylate kinase; Validated; Region: tmk; PRK00698
444177000388	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
444177000389	TMP-binding site; other site
444177000390	ATP-binding site [chemical binding]; other site
444177000391	Protein of unknown function (DUF970); Region: DUF970; cl17525
444177000392	Protein of unknown function (DUF327); Region: DUF327; pfam03885
444177000393	DNA polymerase III subunit delta'; Validated; Region: PRK08058
444177000394	DNA polymerase III subunit delta'; Validated; Region: PRK08485
444177000395	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
444177000396	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
444177000397	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
444177000398	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177000399	S-adenosylmethionine binding site [chemical binding]; other site
444177000400	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
444177000401	putative active site [active]
444177000402	GIY-YIG motif/motif A; other site
444177000403	putative metal binding site [ion binding]; other site
444177000404	Predicted methyltransferases [General function prediction only]; Region: COG0313
444177000405	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
444177000406	putative SAM binding site [chemical binding]; other site
444177000407	putative homodimer interface [polypeptide binding]; other site
444177000408	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
444177000409	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
444177000410	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
444177000411	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
444177000412	active site
444177000413	HIGH motif; other site
444177000414	KMSKS motif; other site
444177000415	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
444177000416	tRNA binding surface [nucleotide binding]; other site
444177000417	anticodon binding site; other site
444177000418	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
444177000419	dimer interface [polypeptide binding]; other site
444177000420	putative tRNA-binding site [nucleotide binding]; other site
444177000421	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
444177000422	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
444177000423	active site
444177000424	Domain of unknown function (DUF348); Region: DUF348; pfam03990
444177000425	Domain of unknown function (DUF348); Region: DUF348; pfam03990
444177000426	Domain of unknown function (DUF348); Region: DUF348; pfam03990
444177000427	G5 domain; Region: G5; pfam07501
444177000428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
444177000429	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
444177000430	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
444177000431	putative active site [active]
444177000432	putative metal binding site [ion binding]; other site
444177000433	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
444177000434	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
444177000435	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177000436	S-adenosylmethionine binding site [chemical binding]; other site
444177000437	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
444177000438	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
444177000439	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
444177000440	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
444177000441	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
444177000442	pur operon repressor; Provisional; Region: PRK09213
444177000443	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
444177000444	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
444177000445	active site
444177000446	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
444177000447	homotrimer interaction site [polypeptide binding]; other site
444177000448	putative active site [active]
444177000449	SpoVG; Region: SpoVG; cl00915
444177000450	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
444177000451	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
444177000452	Substrate binding site; other site
444177000453	Mg++ binding site; other site
444177000454	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
444177000455	active site
444177000456	substrate binding site [chemical binding]; other site
444177000457	CoA binding site [chemical binding]; other site
444177000458	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
444177000459	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
444177000460	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
444177000461	active site
444177000462	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
444177000463	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
444177000464	5S rRNA interface [nucleotide binding]; other site
444177000465	CTC domain interface [polypeptide binding]; other site
444177000466	L16 interface [polypeptide binding]; other site
444177000467	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
444177000468	putative active site [active]
444177000469	catalytic residue [active]
444177000470	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
444177000471	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
444177000472	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
444177000473	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
444177000474	ATP binding site [chemical binding]; other site
444177000475	putative Mg++ binding site [ion binding]; other site
444177000476	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177000477	nucleotide binding region [chemical binding]; other site
444177000478	ATP-binding site [chemical binding]; other site
444177000479	TRCF domain; Region: TRCF; pfam03461
444177000480	stage V sporulation protein T; Region: spore_V_T; TIGR02851
444177000481	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
444177000482	stage V sporulation protein B; Region: spore_V_B; TIGR02900
444177000483	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
444177000484	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
444177000485	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
444177000486	putative SAM binding site [chemical binding]; other site
444177000487	putative homodimer interface [polypeptide binding]; other site
444177000488	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
444177000489	homodimer interface [polypeptide binding]; other site
444177000490	metal binding site [ion binding]; metal-binding site
444177000491	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
444177000492	homodimer interface [polypeptide binding]; other site
444177000493	active site
444177000494	putative chemical substrate binding site [chemical binding]; other site
444177000495	metal binding site [ion binding]; metal-binding site
444177000496	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
444177000497	RNA binding surface [nucleotide binding]; other site
444177000498	YabP family; Region: YabP; cl06766
444177000499	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
444177000500	Septum formation initiator; Region: DivIC; pfam04977
444177000501	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
444177000502	hypothetical protein; Provisional; Region: PRK08582
444177000503	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
444177000504	RNA binding site [nucleotide binding]; other site
444177000505	stage II sporulation protein E; Region: spore_II_E; TIGR02865
444177000506	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
444177000507	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
444177000508	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
444177000509	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
444177000510	Ligand Binding Site [chemical binding]; other site
444177000511	TilS substrate C-terminal domain; Region: TilS_C; smart00977
444177000512	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
444177000513	active site
444177000514	FtsH Extracellular; Region: FtsH_ext; pfam06480
444177000515	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
444177000516	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177000517	Walker A motif; other site
444177000518	ATP binding site [chemical binding]; other site
444177000519	Walker B motif; other site
444177000520	arginine finger; other site
444177000521	Peptidase family M41; Region: Peptidase_M41; pfam01434
444177000522	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
444177000523	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
444177000524	active site
444177000525	catalytic tetrad [active]
444177000526	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
444177000527	nucleotide binding site [chemical binding]; other site
444177000528	Type III pantothenate kinase; Region: Pan_kinase; cl17198
444177000529	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
444177000530	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
444177000531	dimerization interface [polypeptide binding]; other site
444177000532	domain crossover interface; other site
444177000533	redox-dependent activation switch; other site
444177000534	SurA N-terminal domain; Region: SurA_N_3; cl07813
444177000535	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
444177000536	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
444177000537	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
444177000538	dimer interface [polypeptide binding]; other site
444177000539	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177000540	catalytic residue [active]
444177000541	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
444177000542	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
444177000543	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
444177000544	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
444177000545	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
444177000546	glutamine binding [chemical binding]; other site
444177000547	catalytic triad [active]
444177000548	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
444177000549	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
444177000550	homodimer interface [polypeptide binding]; other site
444177000551	substrate-cofactor binding pocket; other site
444177000552	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177000553	catalytic residue [active]
444177000554	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
444177000555	dihydropteroate synthase; Region: DHPS; TIGR01496
444177000556	substrate binding pocket [chemical binding]; other site
444177000557	dimer interface [polypeptide binding]; other site
444177000558	inhibitor binding site; inhibition site
444177000559	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
444177000560	homooctamer interface [polypeptide binding]; other site
444177000561	active site
444177000562	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
444177000563	catalytic center binding site [active]
444177000564	ATP binding site [chemical binding]; other site
444177000565	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
444177000566	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
444177000567	FMN binding site [chemical binding]; other site
444177000568	active site
444177000569	catalytic residues [active]
444177000570	substrate binding site [chemical binding]; other site
444177000571	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
444177000572	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
444177000573	dimer interface [polypeptide binding]; other site
444177000574	putative anticodon binding site; other site
444177000575	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
444177000576	motif 1; other site
444177000577	active site
444177000578	motif 2; other site
444177000579	motif 3; other site
444177000580	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
444177000581	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
444177000582	flavoprotein, HI0933 family; Region: TIGR00275
444177000583	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
444177000584	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
444177000585	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
444177000586	PAS domain; Region: PAS; smart00091
444177000587	PAS domain; Region: PAS_9; pfam13426
444177000588	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
444177000589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177000590	Walker A motif; other site
444177000591	ATP binding site [chemical binding]; other site
444177000592	Walker B motif; other site
444177000593	arginine finger; other site
444177000594	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
444177000595	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
444177000596	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
444177000597	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
444177000598	Proline racemase; Region: Pro_racemase; pfam05544
444177000599	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
444177000600	Proline racemase; Region: Pro_racemase; pfam05544
444177000601	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
444177000602	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
444177000603	inhibitor site; inhibition site
444177000604	active site
444177000605	dimer interface [polypeptide binding]; other site
444177000606	catalytic residue [active]
444177000607	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
444177000608	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
444177000609	NAD(P) binding site [chemical binding]; other site
444177000610	catalytic residues [active]
444177000611	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
444177000612	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
444177000613	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
444177000614	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
444177000615	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
444177000616	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
444177000617	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
444177000618	active site
444177000619	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
444177000620	peptide binding site [polypeptide binding]; other site
444177000621	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
444177000622	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
444177000623	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177000624	Walker A/P-loop; other site
444177000625	ATP binding site [chemical binding]; other site
444177000626	Q-loop/lid; other site
444177000627	ABC transporter signature motif; other site
444177000628	Walker B; other site
444177000629	D-loop; other site
444177000630	H-loop/switch region; other site
444177000631	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
444177000632	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177000633	Walker A/P-loop; other site
444177000634	ATP binding site [chemical binding]; other site
444177000635	Q-loop/lid; other site
444177000636	ABC transporter signature motif; other site
444177000637	Walker B; other site
444177000638	D-loop; other site
444177000639	H-loop/switch region; other site
444177000640	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
444177000641	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
444177000642	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
444177000643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177000644	dimer interface [polypeptide binding]; other site
444177000645	conserved gate region; other site
444177000646	putative PBP binding loops; other site
444177000647	ABC-ATPase subunit interface; other site
444177000648	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177000649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177000650	dimer interface [polypeptide binding]; other site
444177000651	conserved gate region; other site
444177000652	putative PBP binding loops; other site
444177000653	ABC-ATPase subunit interface; other site
444177000654	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
444177000655	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
444177000656	Glycoprotease family; Region: Peptidase_M22; pfam00814
444177000657	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
444177000658	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177000659	Coenzyme A binding pocket [chemical binding]; other site
444177000660	UGMP family protein; Validated; Region: PRK09604
444177000661	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
444177000662	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
444177000663	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177000664	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177000665	ABC transporter; Region: ABC_tran_2; pfam12848
444177000666	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177000667	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
444177000668	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
444177000669	CoA binding domain; Region: CoA_binding; pfam02629
444177000670	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
444177000671	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
444177000672	DNA-binding domain; Region: DBINO; pfam13892
444177000673	CAAX protease self-immunity; Region: Abi; pfam02517
444177000674	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
444177000675	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
444177000676	ring oligomerisation interface [polypeptide binding]; other site
444177000677	ATP/Mg binding site [chemical binding]; other site
444177000678	stacking interactions; other site
444177000679	hinge regions; other site
444177000680	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
444177000681	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177000682	ABC-ATPase subunit  interface; other site
444177000683	dimer interface [polypeptide binding]; other site
444177000684	putative PBP binding regions; other site
444177000685	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
444177000686	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
444177000687	Walker A/P-loop; other site
444177000688	ATP binding site [chemical binding]; other site
444177000689	Q-loop/lid; other site
444177000690	ABC transporter signature motif; other site
444177000691	Walker B; other site
444177000692	D-loop; other site
444177000693	H-loop/switch region; other site
444177000694	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177000695	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
444177000696	intersubunit interface [polypeptide binding]; other site
444177000697	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
444177000698	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
444177000699	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
444177000700	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
444177000701	acyl-activating enzyme (AAE) consensus motif; other site
444177000702	AMP binding site [chemical binding]; other site
444177000703	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
444177000704	thioester reductase domain; Region: Thioester-redct; TIGR01746
444177000705	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
444177000706	putative NAD(P) binding site [chemical binding]; other site
444177000707	active site
444177000708	putative substrate binding site [chemical binding]; other site
444177000709	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177000710	dimerization interface [polypeptide binding]; other site
444177000711	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177000712	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177000713	dimer interface [polypeptide binding]; other site
444177000714	putative CheW interface [polypeptide binding]; other site
444177000715	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177000716	AAA domain; Region: AAA_23; pfam13476
444177000717	Walker A/P-loop; other site
444177000718	ATP binding site [chemical binding]; other site
444177000719	AAA domain; Region: AAA_21; pfam13304
444177000720	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
444177000721	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
444177000722	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177000723	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
444177000724	active site
444177000725	S-layer homology domain; Region: SLH; pfam00395
444177000726	YusW-like protein; Region: YusW; pfam14039
444177000727	hydroperoxidase II; Provisional; Region: katE; PRK11249
444177000728	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
444177000729	tetramer interface [polypeptide binding]; other site
444177000730	heme binding pocket [chemical binding]; other site
444177000731	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
444177000732	domain interactions; other site
444177000733	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177000734	MarR family; Region: MarR; pfam01047
444177000735	MarR family; Region: MarR_2; cl17246
444177000736	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
444177000737	Zn binding site [ion binding]; other site
444177000738	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
444177000739	Zn binding site [ion binding]; other site
444177000740	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
444177000741	dimer interface [polypeptide binding]; other site
444177000742	FMN binding site [chemical binding]; other site
444177000743	Predicted flavoprotein [General function prediction only]; Region: COG0431
444177000744	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
444177000745	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177000746	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177000747	dimerization interface [polypeptide binding]; other site
444177000748	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177000749	dimer interface [polypeptide binding]; other site
444177000750	phosphorylation site [posttranslational modification]
444177000751	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177000752	ATP binding site [chemical binding]; other site
444177000753	Mg2+ binding site [ion binding]; other site
444177000754	G-X-G motif; other site
444177000755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177000756	Response regulator receiver domain; Region: Response_reg; pfam00072
444177000757	active site
444177000758	phosphorylation site [posttranslational modification]
444177000759	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177000760	intermolecular recognition site; other site
444177000761	dimerization interface [polypeptide binding]; other site
444177000762	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177000763	DNA binding site [nucleotide binding]
444177000764	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
444177000765	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
444177000766	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
444177000767	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177000768	ABC-ATPase subunit  interface; other site
444177000769	dimer interface [polypeptide binding]; other site
444177000770	putative PBP binding regions; other site
444177000771	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
444177000772	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
444177000773	Walker A/P-loop; other site
444177000774	ATP binding site [chemical binding]; other site
444177000775	Q-loop/lid; other site
444177000776	ABC transporter signature motif; other site
444177000777	Walker B; other site
444177000778	D-loop; other site
444177000779	H-loop/switch region; other site
444177000780	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
444177000781	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
444177000782	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177000783	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177000784	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
444177000785	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
444177000786	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
444177000787	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
444177000788	active site
444177000789	catalytic triad [active]
444177000790	oxyanion hole [active]
444177000791	S-layer homology domain; Region: SLH; pfam00395
444177000792	S-layer homology domain; Region: SLH; pfam00395
444177000793	S-layer homology domain; Region: SLH; pfam00395
444177000794	Ion channel; Region: Ion_trans_2; pfam07885
444177000795	Protein of unknown function (DUF2653); Region: DUF2653; pfam10850
444177000796	Uncharacterized conserved protein [Function unknown]; Region: COG1434
444177000797	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
444177000798	putative active site [active]
444177000799	Sel1 repeat; Region: Sel1; pfam08238
444177000800	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
444177000801	Sel1-like repeats; Region: SEL1; smart00671
444177000802	Sel1-like repeats; Region: SEL1; smart00671
444177000803	Sel1-like repeats; Region: SEL1; smart00671
444177000804	Sel1-like repeats; Region: SEL1; smart00671
444177000805	Sel1-like repeats; Region: SEL1; smart00671
444177000806	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
444177000807	heme-binding site [chemical binding]; other site
444177000808	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177000809	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177000810	dimer interface [polypeptide binding]; other site
444177000811	putative CheW interface [polypeptide binding]; other site
444177000812	protoporphyrinogen oxidase; Provisional; Region: PRK12416
444177000813	protoporphyrinogen oxidase; Provisional; Region: PRK12416
444177000814	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
444177000815	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
444177000816	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
444177000817	FAD binding site [chemical binding]; other site
444177000818	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
444177000819	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
444177000820	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
444177000821	substrate binding pocket [chemical binding]; other site
444177000822	dimer interface [polypeptide binding]; other site
444177000823	inhibitor binding site; inhibition site
444177000824	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
444177000825	B12 binding site [chemical binding]; other site
444177000826	cobalt ligand [ion binding]; other site
444177000827	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
444177000828	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
444177000829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177000830	Coenzyme A binding pocket [chemical binding]; other site
444177000831	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
444177000832	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
444177000833	putative di-iron ligands [ion binding]; other site
444177000834	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177000835	Histidine kinase; Region: HisKA_3; pfam07730
444177000836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177000837	ATP binding site [chemical binding]; other site
444177000838	Mg2+ binding site [ion binding]; other site
444177000839	G-X-G motif; other site
444177000840	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177000841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177000842	active site
444177000843	phosphorylation site [posttranslational modification]
444177000844	intermolecular recognition site; other site
444177000845	dimerization interface [polypeptide binding]; other site
444177000846	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
444177000847	DNA binding residues [nucleotide binding]
444177000848	dimerization interface [polypeptide binding]; other site
444177000849	Proline dehydrogenase; Region: Pro_dh; cl03282
444177000850	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
444177000851	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250
444177000852	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
444177000853	Walker A/P-loop; other site
444177000854	ATP binding site [chemical binding]; other site
444177000855	Q-loop/lid; other site
444177000856	ABC transporter signature motif; other site
444177000857	Walker B; other site
444177000858	D-loop; other site
444177000859	H-loop/switch region; other site
444177000860	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
444177000861	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
444177000862	DNA binding site [nucleotide binding]
444177000863	active site
444177000864	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
444177000865	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
444177000866	Nitrogen regulatory protein P-II; Region: P-II; smart00938
444177000867	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
444177000868	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
444177000869	active site
444177000870	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
444177000871	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
444177000872	homodimer interface [polypeptide binding]; other site
444177000873	NAD binding pocket [chemical binding]; other site
444177000874	ATP binding pocket [chemical binding]; other site
444177000875	Mg binding site [ion binding]; other site
444177000876	active-site loop [active]
444177000877	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
444177000878	NosL; Region: NosL; cl01769
444177000879	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
444177000880	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
444177000881	Walker A/P-loop; other site
444177000882	ATP binding site [chemical binding]; other site
444177000883	Q-loop/lid; other site
444177000884	ABC transporter signature motif; other site
444177000885	Walker B; other site
444177000886	D-loop; other site
444177000887	H-loop/switch region; other site
444177000888	MoxR-like ATPases [General function prediction only]; Region: COG0714
444177000889	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177000890	Walker A motif; other site
444177000891	ATP binding site [chemical binding]; other site
444177000892	Walker B motif; other site
444177000893	arginine finger; other site
444177000894	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
444177000895	Protein of unknown function DUF58; Region: DUF58; pfam01882
444177000896	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
444177000897	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
444177000898	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
444177000899	GMP synthase; Reviewed; Region: guaA; PRK00074
444177000900	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
444177000901	AMP/PPi binding site [chemical binding]; other site
444177000902	candidate oxyanion hole; other site
444177000903	catalytic triad [active]
444177000904	potential glutamine specificity residues [chemical binding]; other site
444177000905	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
444177000906	ATP Binding subdomain [chemical binding]; other site
444177000907	Ligand Binding sites [chemical binding]; other site
444177000908	Dimerization subdomain; other site
444177000909	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
444177000910	MOSC domain; Region: MOSC; pfam03473
444177000911	3-alpha domain; Region: 3-alpha; pfam03475
444177000912	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
444177000913	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
444177000914	NETI protein; Region: NETI; pfam14044
444177000915	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
444177000916	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
444177000917	ATP-grasp domain; Region: ATP-grasp; pfam02222
444177000918	adenylosuccinate lyase; Provisional; Region: PRK07492
444177000919	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
444177000920	tetramer interface [polypeptide binding]; other site
444177000921	active site
444177000922	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
444177000923	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
444177000924	ATP binding site [chemical binding]; other site
444177000925	active site
444177000926	substrate binding site [chemical binding]; other site
444177000927	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
444177000928	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
444177000929	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
444177000930	putative active site [active]
444177000931	catalytic triad [active]
444177000932	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
444177000933	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
444177000934	dimerization interface [polypeptide binding]; other site
444177000935	ATP binding site [chemical binding]; other site
444177000936	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
444177000937	dimerization interface [polypeptide binding]; other site
444177000938	ATP binding site [chemical binding]; other site
444177000939	amidophosphoribosyltransferase; Provisional; Region: PRK07631
444177000940	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
444177000941	active site
444177000942	tetramer interface [polypeptide binding]; other site
444177000943	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
444177000944	active site
444177000945	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
444177000946	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
444177000947	dimerization interface [polypeptide binding]; other site
444177000948	putative ATP binding site [chemical binding]; other site
444177000949	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
444177000950	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
444177000951	active site
444177000952	substrate binding site [chemical binding]; other site
444177000953	cosubstrate binding site; other site
444177000954	catalytic site [active]
444177000955	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
444177000956	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
444177000957	purine monophosphate binding site [chemical binding]; other site
444177000958	dimer interface [polypeptide binding]; other site
444177000959	putative catalytic residues [active]
444177000960	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
444177000961	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
444177000962	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
444177000963	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
444177000964	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
444177000965	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
444177000966	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
444177000967	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
444177000968	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
444177000969	active site
444177000970	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
444177000971	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
444177000972	Trp repressor protein; Region: Trp_repressor; cl17266
444177000973	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
444177000974	dimer interface [polypeptide binding]; other site
444177000975	substrate binding site [chemical binding]; other site
444177000976	putative active site [active]
444177000977	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
444177000978	Part of AAA domain; Region: AAA_19; pfam13245
444177000979	Family description; Region: UvrD_C_2; pfam13538
444177000980	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
444177000981	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
444177000982	nucleotide binding pocket [chemical binding]; other site
444177000983	K-X-D-G motif; other site
444177000984	catalytic site [active]
444177000985	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
444177000986	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
444177000987	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
444177000988	Dimer interface [polypeptide binding]; other site
444177000989	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
444177000990	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
444177000991	putative dimer interface [polypeptide binding]; other site
444177000992	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
444177000993	putative dimer interface [polypeptide binding]; other site
444177000994	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
444177000995	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
444177000996	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
444177000997	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
444177000998	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
444177000999	GatB domain; Region: GatB_Yqey; pfam02637
444177001000	putative lipid kinase; Reviewed; Region: PRK13337
444177001001	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
444177001002	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
444177001003	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
444177001004	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
444177001005	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
444177001006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177001007	S-adenosylmethionine binding site [chemical binding]; other site
444177001008	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
444177001009	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
444177001010	FMN binding site [chemical binding]; other site
444177001011	active site
444177001012	catalytic residues [active]
444177001013	substrate binding site [chemical binding]; other site
444177001014	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
444177001015	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
444177001016	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
444177001017	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
444177001018	amphipathic channel; other site
444177001019	Asn-Pro-Ala signature motifs; other site
444177001020	glycerol kinase; Provisional; Region: glpK; PRK00047
444177001021	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
444177001022	N- and C-terminal domain interface [polypeptide binding]; other site
444177001023	active site
444177001024	MgATP binding site [chemical binding]; other site
444177001025	catalytic site [active]
444177001026	metal binding site [ion binding]; metal-binding site
444177001027	glycerol binding site [chemical binding]; other site
444177001028	homotetramer interface [polypeptide binding]; other site
444177001029	homodimer interface [polypeptide binding]; other site
444177001030	FBP binding site [chemical binding]; other site
444177001031	protein IIAGlc interface [polypeptide binding]; other site
444177001032	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
444177001033	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
444177001034	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
444177001035	benzoate transport; Region: 2A0115; TIGR00895
444177001036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177001037	putative substrate translocation pore; other site
444177001038	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
444177001039	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
444177001040	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
444177001041	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177001042	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177001043	dimer interface [polypeptide binding]; other site
444177001044	putative CheW interface [polypeptide binding]; other site
444177001045	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
444177001046	classical (c) SDRs; Region: SDR_c; cd05233
444177001047	NAD(P) binding site [chemical binding]; other site
444177001048	active site
444177001049	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
444177001050	Na binding site [ion binding]; other site
444177001051	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177001052	dimerization interface [polypeptide binding]; other site
444177001053	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177001054	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177001055	dimer interface [polypeptide binding]; other site
444177001056	putative CheW interface [polypeptide binding]; other site
444177001057	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
444177001058	Peptidase family M23; Region: Peptidase_M23; pfam01551
444177001059	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
444177001060	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
444177001061	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
444177001062	SpoVR like protein; Region: SpoVR; pfam04293
444177001063	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
444177001064	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
444177001065	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177001066	FeS/SAM binding site; other site
444177001067	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
444177001068	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
444177001069	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177001070	non-specific DNA binding site [nucleotide binding]; other site
444177001071	salt bridge; other site
444177001072	sequence-specific DNA binding site [nucleotide binding]; other site
444177001073	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
444177001074	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177001075	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
444177001076	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
444177001077	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
444177001078	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177001079	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
444177001080	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
444177001081	Domain of unknown function (DUF305); Region: DUF305; pfam03713
444177001082	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
444177001083	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
444177001084	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
444177001085	acyl-activating enzyme (AAE) consensus motif; other site
444177001086	putative AMP binding site [chemical binding]; other site
444177001087	putative active site [active]
444177001088	putative CoA binding site [chemical binding]; other site
444177001089	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
444177001090	putative active site [active]
444177001091	ATP-grasp domain; Region: ATP-grasp_4; cl17255
444177001092	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
444177001093	aspartate racemase; Region: asp_race; TIGR00035
444177001094	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
444177001095	DEAD-like helicases superfamily; Region: DEXDc; smart00487
444177001096	ATP binding site [chemical binding]; other site
444177001097	putative Mg++ binding site [ion binding]; other site
444177001098	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177001099	nucleotide binding region [chemical binding]; other site
444177001100	ATP-binding site [chemical binding]; other site
444177001101	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
444177001102	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
444177001103	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
444177001104	active site
444177001105	catalytic triad [active]
444177001106	oxyanion hole [active]
444177001107	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
444177001108	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
444177001109	active site
444177001110	metal binding site [ion binding]; metal-binding site
444177001111	DNA binding site [nucleotide binding]
444177001112	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
444177001113	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
444177001114	AAA domain; Region: AAA_23; pfam13476
444177001115	Walker A/P-loop; other site
444177001116	ATP binding site [chemical binding]; other site
444177001117	Q-loop/lid; other site
444177001118	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
444177001119	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
444177001120	ABC transporter signature motif; other site
444177001121	Walker B; other site
444177001122	D-loop; other site
444177001123	H-loop/switch region; other site
444177001124	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
444177001125	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
444177001126	active site
444177001127	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
444177001128	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177001129	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177001130	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
444177001131	active site clefts [active]
444177001132	zinc binding site [ion binding]; other site
444177001133	dimer interface [polypeptide binding]; other site
444177001134	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
444177001135	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
444177001136	flagellar motor protein MotA; Validated; Region: PRK08124
444177001137	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
444177001138	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
444177001139	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
444177001140	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
444177001141	ligand binding site [chemical binding]; other site
444177001142	Protein of unknown function (DUF1128); Region: DUF1128; pfam06569
444177001143	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
444177001144	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
444177001145	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
444177001146	Soluble P-type ATPase [General function prediction only]; Region: COG4087
444177001147	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
444177001148	Fumarase C-terminus; Region: Fumerase_C; pfam05683
444177001149	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
444177001150	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177001151	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177001152	putative substrate translocation pore; other site
444177001153	TRAM domain; Region: TRAM; pfam01938
444177001154	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
444177001155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177001156	S-adenosylmethionine binding site [chemical binding]; other site
444177001157	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
444177001158	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
444177001159	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
444177001160	TIGR01777 family protein; Region: yfcH
444177001161	putative NAD(P) binding site [chemical binding]; other site
444177001162	putative active site [active]
444177001163	recombination regulator RecX; Provisional; Region: recX; PRK14135
444177001164	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
444177001165	WVELL protein; Region: WVELL; pfam14043
444177001166	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
444177001167	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
444177001168	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
444177001169	minor groove reading motif; other site
444177001170	helix-hairpin-helix signature motif; other site
444177001171	substrate binding pocket [chemical binding]; other site
444177001172	active site
444177001173	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
444177001174	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
444177001175	DNA binding and oxoG recognition site [nucleotide binding]
444177001176	hypothetical protein; Provisional; Region: PRK13662
444177001177	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
444177001178	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
444177001179	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
444177001180	Walker A/P-loop; other site
444177001181	ATP binding site [chemical binding]; other site
444177001182	Q-loop/lid; other site
444177001183	ABC transporter signature motif; other site
444177001184	Walker B; other site
444177001185	D-loop; other site
444177001186	H-loop/switch region; other site
444177001187	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
444177001188	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177001189	Walker A/P-loop; other site
444177001190	ATP binding site [chemical binding]; other site
444177001191	Q-loop/lid; other site
444177001192	ABC transporter signature motif; other site
444177001193	Walker B; other site
444177001194	D-loop; other site
444177001195	H-loop/switch region; other site
444177001196	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
444177001197	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
444177001198	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177001199	Walker A/P-loop; other site
444177001200	ATP binding site [chemical binding]; other site
444177001201	Q-loop/lid; other site
444177001202	ABC transporter signature motif; other site
444177001203	Walker B; other site
444177001204	D-loop; other site
444177001205	H-loop/switch region; other site
444177001206	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
444177001207	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
444177001208	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
444177001209	peptide binding site [polypeptide binding]; other site
444177001210	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177001211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177001212	putative PBP binding loops; other site
444177001213	dimer interface [polypeptide binding]; other site
444177001214	ABC-ATPase subunit interface; other site
444177001215	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
444177001216	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
444177001217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177001218	dimer interface [polypeptide binding]; other site
444177001219	conserved gate region; other site
444177001220	ABC-ATPase subunit interface; other site
444177001221	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
444177001222	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
444177001223	putative metal binding site [ion binding]; other site
444177001224	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
444177001225	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
444177001226	putative metal binding site [ion binding]; other site
444177001227	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
444177001228	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
444177001229	putative metal binding site [ion binding]; other site
444177001230	Integral membrane protein TerC family; Region: TerC; cl10468
444177001231	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
444177001232	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
444177001233	active site
444177001234	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
444177001235	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
444177001236	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
444177001237	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
444177001238	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
444177001239	Predicted membrane protein [Function unknown]; Region: COG4129
444177001240	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
444177001241	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
444177001242	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
444177001243	inhibitor-cofactor binding pocket; inhibition site
444177001244	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177001245	catalytic residue [active]
444177001246	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
444177001247	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
444177001248	catalytic triad [active]
444177001249	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
444177001250	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
444177001251	NAD binding site [chemical binding]; other site
444177001252	ligand binding site [chemical binding]; other site
444177001253	catalytic site [active]
444177001254	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
444177001255	metal binding site 2 [ion binding]; metal-binding site
444177001256	putative DNA binding helix; other site
444177001257	metal binding site 1 [ion binding]; metal-binding site
444177001258	dimer interface [polypeptide binding]; other site
444177001259	structural Zn2+ binding site [ion binding]; other site
444177001260	Protein of unknown function (DUF2614); Region: DUF2614; pfam11023
444177001261	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
444177001262	active site
444177001263	catalytic residues [active]
444177001264	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177001265	non-specific DNA binding site [nucleotide binding]; other site
444177001266	salt bridge; other site
444177001267	sequence-specific DNA binding site [nucleotide binding]; other site
444177001268	Tetratricopeptide repeat; Region: TPR_12; pfam13424
444177001269	Tetratricopeptide repeat; Region: TPR_12; pfam13424
444177001270	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
444177001271	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
444177001272	FtsX-like permease family; Region: FtsX; pfam02687
444177001273	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
444177001274	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
444177001275	Walker A/P-loop; other site
444177001276	ATP binding site [chemical binding]; other site
444177001277	Q-loop/lid; other site
444177001278	ABC transporter signature motif; other site
444177001279	Walker B; other site
444177001280	D-loop; other site
444177001281	H-loop/switch region; other site
444177001282	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
444177001283	classical (c) SDRs; Region: SDR_c; cd05233
444177001284	NAD(P) binding site [chemical binding]; other site
444177001285	active site
444177001286	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
444177001287	active site
444177001288	catalytic triad [active]
444177001289	oxyanion hole [active]
444177001290	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177001291	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177001292	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
444177001293	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
444177001294	S-layer homology domain; Region: SLH; pfam00395
444177001295	S-layer homology domain; Region: SLH; pfam00395
444177001296	S-layer homology domain; Region: SLH; pfam00395
444177001297	N-acetyltransferase; Region: Acetyltransf_2; cl00949
444177001298	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
444177001299	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
444177001300	active site
444177001301	trimer interface [polypeptide binding]; other site
444177001302	allosteric site; other site
444177001303	active site lid [active]
444177001304	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
444177001305	dimer interface [polypeptide binding]; other site
444177001306	catalytic triad [active]
444177001307	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
444177001308	active site
444177001309	catalytic motif [active]
444177001310	Zn binding site [ion binding]; other site
444177001311	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
444177001312	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
444177001313	tetramer interface [polypeptide binding]; other site
444177001314	heme binding pocket [chemical binding]; other site
444177001315	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
444177001316	B3/4 domain; Region: B3_4; pfam03483
444177001317	epoxyqueuosine reductase; Region: TIGR00276
444177001318	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
444177001319	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
444177001320	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
444177001321	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
444177001322	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
444177001323	putative metal binding site [ion binding]; other site
444177001324	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
444177001325	active site
444177001326	metal binding site [ion binding]; metal-binding site
444177001327	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
444177001328	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
444177001329	active site
444177001330	catalytic tetrad [active]
444177001331	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
444177001332	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
444177001333	active site
444177001334	putative disulfide oxidoreductase; Provisional; Region: PRK03113
444177001335	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
444177001336	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
444177001337	Histidine kinase; Region: HisKA_3; pfam07730
444177001338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177001339	ATP binding site [chemical binding]; other site
444177001340	Mg2+ binding site [ion binding]; other site
444177001341	G-X-G motif; other site
444177001342	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177001343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177001344	active site
444177001345	phosphorylation site [posttranslational modification]
444177001346	intermolecular recognition site; other site
444177001347	dimerization interface [polypeptide binding]; other site
444177001348	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
444177001349	DNA binding residues [nucleotide binding]
444177001350	dimerization interface [polypeptide binding]; other site
444177001351	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177001352	active site
444177001353	dimerization interface [polypeptide binding]; other site
444177001354	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
444177001355	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
444177001356	Predicted transcriptional regulator [Transcription]; Region: COG2378
444177001357	HTH domain; Region: HTH_11; pfam08279
444177001358	WYL domain; Region: WYL; pfam13280
444177001359	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
444177001360	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
444177001361	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
444177001362	Cation efflux family; Region: Cation_efflux; cl00316
444177001363	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
444177001364	Domain of unknown function DUF21; Region: DUF21; pfam01595
444177001365	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
444177001366	Transporter associated domain; Region: CorC_HlyC; smart01091
444177001367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
444177001368	hypothetical protein; Provisional; Region: PRK13676
444177001369	hypothetical protein; Validated; Region: PRK07708
444177001370	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
444177001371	RNA/DNA hybrid binding site [nucleotide binding]; other site
444177001372	active site
444177001373	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177001374	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
444177001375	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177001376	FeS/SAM binding site; other site
444177001377	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
444177001378	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
444177001379	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
444177001380	glycerate kinase; Region: TIGR00045
444177001381	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
444177001382	fructuronate transporter; Provisional; Region: PRK10034; cl15264
444177001383	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
444177001384	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
444177001385	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177001386	Lamin Tail Domain; Region: LTD; pfam00932
444177001387	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
444177001388	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
444177001389	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177001390	motif II; other site
444177001391	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
444177001392	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
444177001393	ligand binding site [chemical binding]; other site
444177001394	NAD binding site [chemical binding]; other site
444177001395	dimerization interface [polypeptide binding]; other site
444177001396	catalytic site [active]
444177001397	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
444177001398	putative L-serine binding site [chemical binding]; other site
444177001399	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
444177001400	FAD binding domain; Region: FAD_binding_2; pfam00890
444177001401	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
444177001402	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
444177001403	active site residue [active]
444177001404	enoyl-CoA hydratase; Provisional; Region: PRK07659
444177001405	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
444177001406	substrate binding site [chemical binding]; other site
444177001407	oxyanion hole (OAH) forming residues; other site
444177001408	trimer interface [polypeptide binding]; other site
444177001409	YhzD-like protein; Region: YhzD; pfam14120
444177001410	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
444177001411	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
444177001412	active site
444177001413	metal binding site [ion binding]; metal-binding site
444177001414	DNA binding site [nucleotide binding]
444177001415	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177001416	Walker A/P-loop; other site
444177001417	ATP binding site [chemical binding]; other site
444177001418	Uncharacterized conserved protein [Function unknown]; Region: COG4717
444177001419	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177001420	Q-loop/lid; other site
444177001421	ABC transporter signature motif; other site
444177001422	Walker B; other site
444177001423	D-loop; other site
444177001424	H-loop/switch region; other site
444177001425	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
444177001426	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
444177001427	generic binding surface II; other site
444177001428	generic binding surface I; other site
444177001429	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177001430	Zn2+ binding site [ion binding]; other site
444177001431	Mg2+ binding site [ion binding]; other site
444177001432	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998
444177001433	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
444177001434	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
444177001435	transcriptional regulator Hpr; Provisional; Region: PRK13777
444177001436	MarR family; Region: MarR; pfam01047
444177001437	YtxH-like protein; Region: YtxH; cl02079
444177001438	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
444177001439	HIT family signature motif; other site
444177001440	catalytic residue [active]
444177001441	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
444177001442	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
444177001443	Walker A/P-loop; other site
444177001444	ATP binding site [chemical binding]; other site
444177001445	Q-loop/lid; other site
444177001446	ABC transporter signature motif; other site
444177001447	Walker B; other site
444177001448	D-loop; other site
444177001449	H-loop/switch region; other site
444177001450	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
444177001451	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
444177001452	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
444177001453	substrate binding site [chemical binding]; other site
444177001454	active site
444177001455	ferrochelatase; Provisional; Region: PRK12435
444177001456	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
444177001457	C-terminal domain interface [polypeptide binding]; other site
444177001458	active site
444177001459	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
444177001460	active site
444177001461	N-terminal domain interface [polypeptide binding]; other site
444177001462	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
444177001463	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
444177001464	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
444177001465	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
444177001466	putative metal binding site; other site
444177001467	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177001468	binding surface
444177001469	TPR motif; other site
444177001470	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
444177001471	Trp docking motif [polypeptide binding]; other site
444177001472	active site
444177001473	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177001474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177001475	active site
444177001476	phosphorylation site [posttranslational modification]
444177001477	intermolecular recognition site; other site
444177001478	dimerization interface [polypeptide binding]; other site
444177001479	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177001480	DNA binding site [nucleotide binding]
444177001481	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177001482	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177001483	dimerization interface [polypeptide binding]; other site
444177001484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177001485	dimer interface [polypeptide binding]; other site
444177001486	phosphorylation site [posttranslational modification]
444177001487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177001488	ATP binding site [chemical binding]; other site
444177001489	Mg2+ binding site [ion binding]; other site
444177001490	G-X-G motif; other site
444177001491	YtkA-like; Region: YtkA; pfam13115
444177001492	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177001493	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177001494	Predicted membrane protein [Function unknown]; Region: COG1511
444177001495	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
444177001496	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
444177001497	YhfH-like protein; Region: YhfH; pfam14149
444177001498	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
444177001499	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
444177001500	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
444177001501	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177001502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177001503	active site
444177001504	phosphorylation site [posttranslational modification]
444177001505	intermolecular recognition site; other site
444177001506	dimerization interface [polypeptide binding]; other site
444177001507	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177001508	DNA binding site [nucleotide binding]
444177001509	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177001510	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
444177001511	dimer interface [polypeptide binding]; other site
444177001512	phosphorylation site [posttranslational modification]
444177001513	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177001514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177001515	ATP binding site [chemical binding]; other site
444177001516	Mg2+ binding site [ion binding]; other site
444177001517	G-X-G motif; other site
444177001518	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
444177001519	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
444177001520	Walker A/P-loop; other site
444177001521	ATP binding site [chemical binding]; other site
444177001522	Q-loop/lid; other site
444177001523	ABC transporter signature motif; other site
444177001524	Walker B; other site
444177001525	D-loop; other site
444177001526	H-loop/switch region; other site
444177001527	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
444177001528	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
444177001529	acyl-activating enzyme (AAE) consensus motif; other site
444177001530	putative AMP binding site [chemical binding]; other site
444177001531	putative active site [active]
444177001532	putative CoA binding site [chemical binding]; other site
444177001533	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
444177001534	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
444177001535	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
444177001536	EAL domain; Region: EAL; pfam00563
444177001537	Uncharacterized conserved protein [Function unknown]; Region: COG1284
444177001538	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
444177001539	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
444177001540	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
444177001541	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
444177001542	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
444177001543	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
444177001544	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
444177001545	Hpr binding site; other site
444177001546	active site
444177001547	homohexamer subunit interaction site [polypeptide binding]; other site
444177001548	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
444177001549	pyrophosphatase PpaX; Provisional; Region: PRK13288
444177001550	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
444177001551	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177001552	motif II; other site
444177001553	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
444177001554	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
444177001555	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
444177001556	trimer interface [polypeptide binding]; other site
444177001557	active site
444177001558	substrate binding site [chemical binding]; other site
444177001559	CoA binding site [chemical binding]; other site
444177001560	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
444177001561	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
444177001562	dimer interface [polypeptide binding]; other site
444177001563	motif 1; other site
444177001564	active site
444177001565	motif 2; other site
444177001566	motif 3; other site
444177001567	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
444177001568	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
444177001569	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
444177001570	histidinol dehydrogenase; Region: hisD; TIGR00069
444177001571	NAD binding site [chemical binding]; other site
444177001572	dimerization interface [polypeptide binding]; other site
444177001573	product binding site; other site
444177001574	substrate binding site [chemical binding]; other site
444177001575	zinc binding site [ion binding]; other site
444177001576	catalytic residues [active]
444177001577	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
444177001578	putative active site pocket [active]
444177001579	4-fold oligomerization interface [polypeptide binding]; other site
444177001580	metal binding residues [ion binding]; metal-binding site
444177001581	3-fold/trimer interface [polypeptide binding]; other site
444177001582	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
444177001583	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
444177001584	putative active site [active]
444177001585	oxyanion strand; other site
444177001586	catalytic triad [active]
444177001587	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
444177001588	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
444177001589	substrate binding site [chemical binding]; other site
444177001590	glutamase interaction surface [polypeptide binding]; other site
444177001591	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
444177001592	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
444177001593	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
444177001594	metal binding site [ion binding]; metal-binding site
444177001595	TPR repeat; Region: TPR_11; pfam13414
444177001596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177001597	TPR motif; other site
444177001598	binding surface
444177001599	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177001600	binding surface
444177001601	TPR motif; other site
444177001602	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
444177001603	DNA-binding interface [nucleotide binding]; DNA binding site
444177001604	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
444177001605	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
444177001606	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
444177001607	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
444177001608	putative active site [active]
444177001609	nucleotide binding site [chemical binding]; other site
444177001610	nudix motif; other site
444177001611	putative metal binding site [ion binding]; other site
444177001612	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
444177001613	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
444177001614	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
444177001615	putative substrate binding pocket [chemical binding]; other site
444177001616	dimer interface [polypeptide binding]; other site
444177001617	phosphate binding site [ion binding]; other site
444177001618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
444177001619	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
444177001620	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
444177001621	dimerization domain swap beta strand [polypeptide binding]; other site
444177001622	regulatory protein interface [polypeptide binding]; other site
444177001623	active site
444177001624	regulatory phosphorylation site [posttranslational modification]; other site
444177001625	Clp protease; Region: CLP_protease; pfam00574
444177001626	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
444177001627	oligomer interface [polypeptide binding]; other site
444177001628	active site residues [active]
444177001629	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
444177001630	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
444177001631	substrate binding pocket [chemical binding]; other site
444177001632	membrane-bound complex binding site; other site
444177001633	hinge residues; other site
444177001634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177001635	dimer interface [polypeptide binding]; other site
444177001636	conserved gate region; other site
444177001637	putative PBP binding loops; other site
444177001638	ABC-ATPase subunit interface; other site
444177001639	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
444177001640	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
444177001641	Walker A/P-loop; other site
444177001642	ATP binding site [chemical binding]; other site
444177001643	Q-loop/lid; other site
444177001644	ABC transporter signature motif; other site
444177001645	Walker B; other site
444177001646	D-loop; other site
444177001647	H-loop/switch region; other site
444177001648	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
444177001649	Repair protein; Region: Repair_PSII; pfam04536
444177001650	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
444177001651	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
444177001652	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
444177001653	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
444177001654	Predicted transcriptional regulator [Transcription]; Region: COG3388
444177001655	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
444177001656	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
444177001657	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
444177001658	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
444177001659	Phosphoglycerate kinase; Region: PGK; pfam00162
444177001660	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
444177001661	substrate binding site [chemical binding]; other site
444177001662	hinge regions; other site
444177001663	ADP binding site [chemical binding]; other site
444177001664	catalytic site [active]
444177001665	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
444177001666	triosephosphate isomerase; Provisional; Region: PRK14565
444177001667	substrate binding site [chemical binding]; other site
444177001668	dimer interface [polypeptide binding]; other site
444177001669	catalytic triad [active]
444177001670	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
444177001671	phosphoglyceromutase; Provisional; Region: PRK05434
444177001672	enolase; Provisional; Region: eno; PRK00077
444177001673	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
444177001674	dimer interface [polypeptide binding]; other site
444177001675	metal binding site [ion binding]; metal-binding site
444177001676	substrate binding pocket [chemical binding]; other site
444177001677	hypothetical protein; Provisional; Region: PRK06770
444177001678	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177001679	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177001680	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
444177001681	DltD N-terminal region; Region: DltD_N; pfam04915
444177001682	DltD central region; Region: DltD_M; pfam04918
444177001683	DltD C-terminal region; Region: DltD_C; pfam04914
444177001684	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
444177001685	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
444177001686	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
444177001687	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
444177001688	acyl-activating enzyme (AAE) consensus motif; other site
444177001689	AMP binding site [chemical binding]; other site
444177001690	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
444177001691	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
444177001692	active site
444177001693	dimer interface [polypeptide binding]; other site
444177001694	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
444177001695	Esterase/lipase [General function prediction only]; Region: COG1647
444177001696	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
444177001697	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
444177001698	ribonuclease R; Region: RNase_R; TIGR02063
444177001699	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
444177001700	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
444177001701	RNB domain; Region: RNB; pfam00773
444177001702	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
444177001703	RNA binding site [nucleotide binding]; other site
444177001704	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
444177001705	SmpB-tmRNA interface; other site
444177001706	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
444177001707	Int/Topo IB signature motif; other site
444177001708	Helix-turn-helix domain; Region: HTH_17; pfam12728
444177001709	D5 N terminal like; Region: D5_N; pfam08706
444177001710	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
444177001711	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
444177001712	MPN+ (JAMM) motif; other site
444177001713	Zinc-binding site [ion binding]; other site
444177001714	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177001715	sequence-specific DNA binding site [nucleotide binding]; other site
444177001716	salt bridge; other site
444177001717	Domain of unknown function DUF87; Region: DUF87; pfam01935
444177001718	HerA helicase [Replication, recombination, and repair]; Region: COG0433
444177001719	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
444177001720	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177001721	AAA domain; Region: AAA_21; pfam13304
444177001722	Walker A/P-loop; other site
444177001723	ATP binding site [chemical binding]; other site
444177001724	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
444177001725	active site
444177001726	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
444177001727	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
444177001728	cofactor binding site; other site
444177001729	DNA binding site [nucleotide binding]
444177001730	substrate interaction site [chemical binding]; other site
444177001731	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
444177001732	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177001733	dimerization interface [polypeptide binding]; other site
444177001734	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177001735	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177001736	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177001737	dimer interface [polypeptide binding]; other site
444177001738	putative CheW interface [polypeptide binding]; other site
444177001739	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
444177001740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177001741	Coenzyme A binding pocket [chemical binding]; other site
444177001742	Integrase core domain; Region: rve_2; pfam13333
444177001743	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
444177001744	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
444177001745	catalytic site [active]
444177001746	deoxyribose-phosphate aldolase; Provisional; Region: PRK00507
444177001747	catalytic residue [active]
444177001748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177001749	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177001750	putative substrate translocation pore; other site
444177001751	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
444177001752	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
444177001753	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
444177001754	dimer interface [polypeptide binding]; other site
444177001755	pyridoxal binding site [chemical binding]; other site
444177001756	ATP binding site [chemical binding]; other site
444177001757	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
444177001758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177001759	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177001760	Coenzyme A binding pocket [chemical binding]; other site
444177001761	YvrJ protein family; Region: YvrJ; pfam12841
444177001762	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
444177001763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
444177001764	hypothetical protein; Provisional; Region: PRK14082
444177001765	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293
444177001766	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
444177001767	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
444177001768	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
444177001769	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
444177001770	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
444177001771	S-layer homology domain; Region: SLH; pfam00395
444177001772	S-layer homology domain; Region: SLH; pfam00395
444177001773	ZIP Zinc transporter; Region: Zip; pfam02535
444177001774	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
444177001775	Predicted oxidoreductase [General function prediction only]; Region: COG3573
444177001776	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
444177001777	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
444177001778	OsmC-like protein; Region: OsmC; cl00767
444177001779	Bacterial sugar transferase; Region: Bac_transf; pfam02397
444177001780	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
444177001781	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
444177001782	putative ADP-binding pocket [chemical binding]; other site
444177001783	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
444177001784	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
444177001785	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929
444177001786	putative active site [active]
444177001787	Agmatinase-like family; Region: Agmatinase-like; cd09990
444177001788	active site
444177001789	oligomer interface [polypeptide binding]; other site
444177001790	Mn binding site [ion binding]; other site
444177001791	5'-3' exonuclease; Region: 53EXOc; smart00475
444177001792	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
444177001793	active site
444177001794	metal binding site 1 [ion binding]; metal-binding site
444177001795	putative 5' ssDNA interaction site; other site
444177001796	metal binding site 3; metal-binding site
444177001797	metal binding site 2 [ion binding]; metal-binding site
444177001798	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
444177001799	putative DNA binding site [nucleotide binding]; other site
444177001800	putative metal binding site [ion binding]; other site
444177001801	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
444177001802	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
444177001803	catalytic residues [active]
444177001804	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
444177001805	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
444177001806	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
444177001807	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
444177001808	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
444177001809	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
444177001810	substrate binding site [chemical binding]; other site
444177001811	oxyanion hole (OAH) forming residues; other site
444177001812	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
444177001813	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
444177001814	dimer interface [polypeptide binding]; other site
444177001815	active site
444177001816	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
444177001817	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
444177001818	active site
444177001819	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
444177001820	ArsC family; Region: ArsC; pfam03960
444177001821	putative ArsC-like catalytic residues; other site
444177001822	putative TRX-like catalytic residues [active]
444177001823	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
444177001824	lipoyl attachment site [posttranslational modification]; other site
444177001825	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
444177001826	active site
444177001827	metal binding site [ion binding]; metal-binding site
444177001828	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
444177001829	catalytic residues [active]
444177001830	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177001831	Walker A/P-loop; other site
444177001832	ATP binding site [chemical binding]; other site
444177001833	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
444177001834	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
444177001835	Q-loop/lid; other site
444177001836	ABC transporter signature motif; other site
444177001837	Walker B; other site
444177001838	D-loop; other site
444177001839	H-loop/switch region; other site
444177001840	NIL domain; Region: NIL; pfam09383
444177001841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177001842	ABC-ATPase subunit interface; other site
444177001843	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
444177001844	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
444177001845	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
444177001846	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
444177001847	NAD(P) binding site [chemical binding]; other site
444177001848	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
444177001849	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
444177001850	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
444177001851	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
444177001852	NodB motif; other site
444177001853	active site
444177001854	catalytic site [active]
444177001855	metal binding site [ion binding]; metal-binding site
444177001856	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
444177001857	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
444177001858	NodB motif; other site
444177001859	active site
444177001860	catalytic site [active]
444177001861	metal binding site [ion binding]; metal-binding site
444177001862	PilZ domain; Region: PilZ; pfam07238
444177001863	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
444177001864	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
444177001865	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
444177001866	DXD motif; other site
444177001867	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
444177001868	GH18 domain of an uncharacterized family of bacterial proteins, which share a common three-domain architecture: an N-terminal glycosyl hydrolase family 18 (GH18) domain, a glycosyl transferase family 2 domain, and a C-terminal polysaccharide deacetylase...; Region: GH18_trifunctional; cd06549
444177001869	putative active site [active]
444177001870	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177001871	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177001872	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
444177001873	putative dimerization interface [polypeptide binding]; other site
444177001874	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
444177001875	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
444177001876	Walker A/P-loop; other site
444177001877	ATP binding site [chemical binding]; other site
444177001878	Q-loop/lid; other site
444177001879	ABC transporter signature motif; other site
444177001880	Walker B; other site
444177001881	D-loop; other site
444177001882	H-loop/switch region; other site
444177001883	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
444177001884	FeS assembly protein SufD; Region: sufD; TIGR01981
444177001885	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
444177001886	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
444177001887	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177001888	catalytic residue [active]
444177001889	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
444177001890	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
444177001891	trimerization site [polypeptide binding]; other site
444177001892	active site
444177001893	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
444177001894	FeS assembly protein SufB; Region: sufB; TIGR01980
444177001895	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177001896	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177001897	intersubunit interface [polypeptide binding]; other site
444177001898	Uncharacterized conserved protein [Function unknown]; Region: COG1801
444177001899	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
444177001900	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
444177001901	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
444177001902	active site
444177001903	metal binding site [ion binding]; metal-binding site
444177001904	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
444177001905	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
444177001906	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
444177001907	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177001908	Zn2+ binding site [ion binding]; other site
444177001909	Mg2+ binding site [ion binding]; other site
444177001910	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
444177001911	lipoyl synthase; Provisional; Region: PRK05481
444177001912	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177001913	FeS/SAM binding site; other site
444177001914	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
444177001915	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
444177001916	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177001917	active site
444177001918	motif I; other site
444177001919	motif II; other site
444177001920	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
444177001921	Uncharacterized conserved protein [Function unknown]; Region: COG2445
444177001922	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
444177001923	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177001924	active site
444177001925	motif I; other site
444177001926	motif II; other site
444177001927	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177001928	motif II; other site
444177001929	Protein of unknown function (DUF1450); Region: DUF1450; pfam07293
444177001930	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
444177001931	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
444177001932	Protein of unknown function (DUF1462); Region: DUF1462; pfam07315
444177001933	NifU-like domain; Region: NifU; pfam01106
444177001934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
444177001935	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
444177001936	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
444177001937	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177001938	Coenzyme A binding pocket [chemical binding]; other site
444177001939	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
444177001940	nudix motif; other site
444177001941	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
444177001942	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
444177001943	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
444177001944	GAF domain; Region: GAF_3; pfam13492
444177001945	Histidine kinase; Region: His_kinase; pfam06580
444177001946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177001947	ATP binding site [chemical binding]; other site
444177001948	Mg2+ binding site [ion binding]; other site
444177001949	G-X-G motif; other site
444177001950	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
444177001951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177001952	active site
444177001953	phosphorylation site [posttranslational modification]
444177001954	intermolecular recognition site; other site
444177001955	dimerization interface [polypeptide binding]; other site
444177001956	LytTr DNA-binding domain; Region: LytTR; pfam04397
444177001957	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
444177001958	Carbon starvation protein CstA; Region: CstA; pfam02554
444177001959	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
444177001960	Putative membrane protein; Region: YuiB; pfam14068
444177001961	Divergent PAP2 family; Region: DUF212; pfam02681
444177001962	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
444177001963	multifunctional aminopeptidase A; Provisional; Region: PRK00913
444177001964	interface (dimer of trimers) [polypeptide binding]; other site
444177001965	Substrate-binding/catalytic site; other site
444177001966	Zn-binding sites [ion binding]; other site
444177001967	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
444177001968	active site
444177001969	SAM binding site [chemical binding]; other site
444177001970	homodimer interface [polypeptide binding]; other site
444177001971	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
444177001972	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
444177001973	putative active site [active]
444177001974	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
444177001975	putative active site [active]
444177001976	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
444177001977	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
444177001978	Flavodoxin; Region: Flavodoxin_1; pfam00258
444177001979	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
444177001980	FAD binding pocket [chemical binding]; other site
444177001981	FAD binding motif [chemical binding]; other site
444177001982	catalytic residues [active]
444177001983	NAD binding pocket [chemical binding]; other site
444177001984	phosphate binding motif [ion binding]; other site
444177001985	beta-alpha-beta structure motif; other site
444177001986	sulfite reductase subunit beta; Provisional; Region: PRK13504
444177001987	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
444177001988	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
444177001989	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
444177001990	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
444177001991	Walker A/P-loop; other site
444177001992	ATP binding site [chemical binding]; other site
444177001993	Q-loop/lid; other site
444177001994	ABC transporter signature motif; other site
444177001995	Walker B; other site
444177001996	D-loop; other site
444177001997	H-loop/switch region; other site
444177001998	TOBE-like domain; Region: TOBE_3; pfam12857
444177001999	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
444177002000	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177002001	dimer interface [polypeptide binding]; other site
444177002002	conserved gate region; other site
444177002003	putative PBP binding loops; other site
444177002004	ABC-ATPase subunit interface; other site
444177002005	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
444177002006	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177002007	dimer interface [polypeptide binding]; other site
444177002008	conserved gate region; other site
444177002009	putative PBP binding loops; other site
444177002010	ABC-ATPase subunit interface; other site
444177002011	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
444177002012	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
444177002013	substrate binding pocket [chemical binding]; other site
444177002014	membrane-bound complex binding site; other site
444177002015	hinge residues; other site
444177002016	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
444177002017	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
444177002018	Active Sites [active]
444177002019	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
444177002020	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
444177002021	ATP-sulfurylase; Region: ATPS; cd00517
444177002022	active site
444177002023	HXXH motif; other site
444177002024	flexible loop; other site
444177002025	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
444177002026	ligand-binding site [chemical binding]; other site
444177002027	Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320
444177002028	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
444177002029	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
444177002030	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
444177002031	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
444177002032	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
444177002033	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
444177002034	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
444177002035	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
444177002036	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
444177002037	Transglycosylase; Region: Transgly; pfam00912
444177002038	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
444177002039	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
444177002040	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
444177002041	active site
444177002042	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
444177002043	oligomer interface [polypeptide binding]; other site
444177002044	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177002045	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177002046	homodimer interface [polypeptide binding]; other site
444177002047	catalytic residue [active]
444177002048	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
444177002049	Domain of unknown function (DUF1871); Region: DUF1871; pfam08958
444177002050	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
444177002051	putative substrate binding site 2 [chemical binding]; other site
444177002052	putative substrate binding site 1 [chemical binding]; other site
444177002053	Na binding site 1 [ion binding]; other site
444177002054	Na2 binding site [ion binding]; other site
444177002055	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177002056	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177002057	DNA binding residues [nucleotide binding]
444177002058	general stress protein 13; Validated; Region: PRK08059
444177002059	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
444177002060	RNA binding site [nucleotide binding]; other site
444177002061	PAS domain S-box; Region: sensory_box; TIGR00229
444177002062	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
444177002063	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
444177002064	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
444177002065	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
444177002066	Glutamate binding site [chemical binding]; other site
444177002067	homodimer interface [polypeptide binding]; other site
444177002068	NAD binding site [chemical binding]; other site
444177002069	catalytic residues [active]
444177002070	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
444177002071	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
444177002072	inhibitor-cofactor binding pocket; inhibition site
444177002073	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177002074	catalytic residue [active]
444177002075	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
444177002076	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
444177002077	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
444177002078	NAD(P) binding site [chemical binding]; other site
444177002079	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
444177002080	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
444177002081	dimer interface [polypeptide binding]; other site
444177002082	active site
444177002083	metal binding site [ion binding]; metal-binding site
444177002084	Homeodomain-like domain; Region: HTH_23; cl17451
444177002085	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
444177002086	Cation efflux family; Region: Cation_efflux; pfam01545
444177002087	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
444177002088	MgtC family; Region: MgtC; pfam02308
444177002089	LytTr DNA-binding domain; Region: LytTR; smart00850
444177002090	isocitrate lyase; Provisional; Region: PRK15063
444177002091	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
444177002092	tetramer interface [polypeptide binding]; other site
444177002093	active site
444177002094	Mg2+/Mn2+ binding site [ion binding]; other site
444177002095	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
444177002096	malate synthase A; Region: malate_syn_A; TIGR01344
444177002097	active site
444177002098	Methyltransferase domain; Region: Methyltransf_31; pfam13847
444177002099	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177002100	S-adenosylmethionine binding site [chemical binding]; other site
444177002101	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177002102	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177002103	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
444177002104	dimerization interface [polypeptide binding]; other site
444177002105	Predicted transcriptional regulators [Transcription]; Region: COG1725
444177002106	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177002107	DNA-binding site [nucleotide binding]; DNA binding site
444177002108	Predicted membrane protein [General function prediction only]; Region: COG4194
444177002109	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
444177002110	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177002111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177002112	active site
444177002113	phosphorylation site [posttranslational modification]
444177002114	intermolecular recognition site; other site
444177002115	dimerization interface [polypeptide binding]; other site
444177002116	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177002117	DNA binding site [nucleotide binding]
444177002118	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177002119	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177002120	dimerization interface [polypeptide binding]; other site
444177002121	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177002122	dimer interface [polypeptide binding]; other site
444177002123	phosphorylation site [posttranslational modification]
444177002124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177002125	ATP binding site [chemical binding]; other site
444177002126	Mg2+ binding site [ion binding]; other site
444177002127	G-X-G motif; other site
444177002128	putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485
444177002129	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
444177002130	Sel1-like repeats; Region: SEL1; smart00671
444177002131	Sel1-like repeats; Region: SEL1; smart00671
444177002132	Sel1-like repeats; Region: SEL1; smart00671
444177002133	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
444177002134	Sel1-like repeats; Region: SEL1; smart00671
444177002135	Sel1-like repeats; Region: SEL1; smart00671
444177002136	Sel1-like repeats; Region: SEL1; smart00671
444177002137	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
444177002138	Sel1-like repeats; Region: SEL1; smart00671
444177002139	Sel1-like repeats; Region: SEL1; smart00671
444177002140	Sel1-like repeats; Region: SEL1; smart00671
444177002141	Sel1-like repeats; Region: SEL1; smart00671
444177002142	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
444177002143	active site
444177002144	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
444177002145	putative homodimer interface [polypeptide binding]; other site
444177002146	putative homotetramer interface [polypeptide binding]; other site
444177002147	putative metal binding site [ion binding]; other site
444177002148	putative homodimer-homodimer interface [polypeptide binding]; other site
444177002149	putative allosteric switch controlling residues; other site
444177002150	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
444177002151	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
444177002152	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
444177002153	argininosuccinate lyase; Provisional; Region: PRK06705
444177002154	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
444177002155	active sites [active]
444177002156	tetramer interface [polypeptide binding]; other site
444177002157	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
444177002158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
444177002159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177002160	dimer interface [polypeptide binding]; other site
444177002161	conserved gate region; other site
444177002162	putative PBP binding loops; other site
444177002163	ABC-ATPase subunit interface; other site
444177002164	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177002165	dimer interface [polypeptide binding]; other site
444177002166	conserved gate region; other site
444177002167	putative PBP binding loops; other site
444177002168	ABC-ATPase subunit interface; other site
444177002169	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
444177002170	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177002171	Walker A/P-loop; other site
444177002172	ATP binding site [chemical binding]; other site
444177002173	Q-loop/lid; other site
444177002174	ABC transporter signature motif; other site
444177002175	Walker B; other site
444177002176	D-loop; other site
444177002177	H-loop/switch region; other site
444177002178	TOBE domain; Region: TOBE_2; pfam08402
444177002179	TOBE domain; Region: TOBE_2; pfam08402
444177002180	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
444177002181	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
444177002182	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
444177002183	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
444177002184	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177002185	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
444177002186	Coenzyme A binding pocket [chemical binding]; other site
444177002187	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
444177002188	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
444177002189	putative substrate binding site [chemical binding]; other site
444177002190	putative ATP binding site [chemical binding]; other site
444177002191	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
444177002192	active site
444177002193	catalytic residues [active]
444177002194	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
444177002195	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
444177002196	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177002197	Walker A/P-loop; other site
444177002198	ATP binding site [chemical binding]; other site
444177002199	Q-loop/lid; other site
444177002200	ABC transporter signature motif; other site
444177002201	Walker B; other site
444177002202	D-loop; other site
444177002203	H-loop/switch region; other site
444177002204	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
444177002205	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
444177002206	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177002207	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177002208	Coenzyme A binding pocket [chemical binding]; other site
444177002209	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
444177002210	Predicted membrane protein [Function unknown]; Region: COG2323
444177002211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177002212	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177002213	putative substrate translocation pore; other site
444177002214	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
444177002215	Ligand Binding Site [chemical binding]; other site
444177002216	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
444177002217	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
444177002218	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
444177002219	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
444177002220	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
444177002221	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
444177002222	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
444177002223	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
444177002224	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
444177002225	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
444177002226	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
444177002227	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
444177002228	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
444177002229	substrate binding pocket [chemical binding]; other site
444177002230	membrane-bound complex binding site; other site
444177002231	hinge residues; other site
444177002232	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
444177002233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177002234	dimer interface [polypeptide binding]; other site
444177002235	conserved gate region; other site
444177002236	putative PBP binding loops; other site
444177002237	ABC-ATPase subunit interface; other site
444177002238	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
444177002239	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
444177002240	Walker A/P-loop; other site
444177002241	ATP binding site [chemical binding]; other site
444177002242	Q-loop/lid; other site
444177002243	ABC transporter signature motif; other site
444177002244	Walker B; other site
444177002245	D-loop; other site
444177002246	H-loop/switch region; other site
444177002247	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
444177002248	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
444177002249	putative active site [active]
444177002250	putative metal binding site [ion binding]; other site
444177002251	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
444177002252	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
444177002253	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
444177002254	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
444177002255	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
444177002256	Cache domain; Region: Cache_1; pfam02743
444177002257	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
444177002258	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177002259	dimerization interface [polypeptide binding]; other site
444177002260	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177002261	dimer interface [polypeptide binding]; other site
444177002262	putative CheW interface [polypeptide binding]; other site
444177002263	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
444177002264	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
444177002265	VanZ like family; Region: VanZ; cl01971
444177002266	RDD family; Region: RDD; cl00746
444177002267	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
444177002268	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
444177002269	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
444177002270	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
444177002271	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
444177002272	catalytic residues [active]
444177002273	dimer interface [polypeptide binding]; other site
444177002274	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
444177002275	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
444177002276	Walker A/P-loop; other site
444177002277	ATP binding site [chemical binding]; other site
444177002278	Q-loop/lid; other site
444177002279	ABC transporter signature motif; other site
444177002280	Walker B; other site
444177002281	D-loop; other site
444177002282	H-loop/switch region; other site
444177002283	CrcB-like protein; Region: CRCB; cl09114
444177002284	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
444177002285	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177002286	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177002287	dimer interface [polypeptide binding]; other site
444177002288	phosphorylation site [posttranslational modification]
444177002289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177002290	ATP binding site [chemical binding]; other site
444177002291	Mg2+ binding site [ion binding]; other site
444177002292	G-X-G motif; other site
444177002293	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177002294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177002295	active site
444177002296	phosphorylation site [posttranslational modification]
444177002297	intermolecular recognition site; other site
444177002298	dimerization interface [polypeptide binding]; other site
444177002299	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177002300	DNA binding site [nucleotide binding]
444177002301	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
444177002302	pentamer interface [polypeptide binding]; other site
444177002303	dodecaamer interface [polypeptide binding]; other site
444177002304	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
444177002305	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
444177002306	HPP family; Region: HPP; pfam04982
444177002307	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
444177002308	CoA-transferase family III; Region: CoA_transf_3; pfam02515
444177002309	Cache domain; Region: Cache_1; pfam02743
444177002310	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177002311	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177002312	metal binding site [ion binding]; metal-binding site
444177002313	active site
444177002314	I-site; other site
444177002315	S-layer homology domain; Region: SLH; pfam00395
444177002316	S-layer homology domain; Region: SLH; pfam00395
444177002317	S-layer homology domain; Region: SLH; pfam00395
444177002318	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
444177002319	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177002320	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177002321	intersubunit interface [polypeptide binding]; other site
444177002322	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177002323	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177002324	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177002325	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
444177002326	intersubunit interface [polypeptide binding]; other site
444177002327	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
444177002328	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177002329	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177002330	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177002331	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177002332	intersubunit interface [polypeptide binding]; other site
444177002333	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
444177002334	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177002335	intersubunit interface [polypeptide binding]; other site
444177002336	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177002337	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177002338	intersubunit interface [polypeptide binding]; other site
444177002339	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177002340	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177002341	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177002342	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177002343	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
444177002344	intersubunit interface [polypeptide binding]; other site
444177002345	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177002346	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177002347	intersubunit interface [polypeptide binding]; other site
444177002348	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
444177002349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177002350	active site
444177002351	phosphorylation site [posttranslational modification]
444177002352	intermolecular recognition site; other site
444177002353	dimerization interface [polypeptide binding]; other site
444177002354	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
444177002355	Cache domain; Region: Cache_1; pfam02743
444177002356	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177002357	dimerization interface [polypeptide binding]; other site
444177002358	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177002359	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177002360	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177002361	dimer interface [polypeptide binding]; other site
444177002362	putative CheW interface [polypeptide binding]; other site
444177002363	Predicted permeases [General function prediction only]; Region: COG0679
444177002364	ThiC-associated domain; Region: ThiC-associated; pfam13667
444177002365	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
444177002366	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
444177002367	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
444177002368	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
444177002369	tetramer interface [polypeptide binding]; other site
444177002370	heme binding pocket [chemical binding]; other site
444177002371	NADPH binding site [chemical binding]; other site
444177002372	Response regulator receiver domain; Region: Response_reg; pfam00072
444177002373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
444177002374	active site
444177002375	phosphorylation site [posttranslational modification]
444177002376	intermolecular recognition site; other site
444177002377	dimerization interface [polypeptide binding]; other site
444177002378	Transcriptional regulator; Region: Rrf2; cl17282
444177002379	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177002380	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177002381	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
444177002382	active sites [active]
444177002383	tetramer interface [polypeptide binding]; other site
444177002384	urocanate hydratase; Provisional; Region: PRK05414
444177002385	imidazolonepropionase; Validated; Region: PRK09356
444177002386	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
444177002387	active site
444177002388	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
444177002389	nudix motif; other site
444177002390	Isochorismatase family; Region: Isochorismatase; pfam00857
444177002391	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
444177002392	catalytic triad [active]
444177002393	conserved cis-peptide bond; other site
444177002394	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
444177002395	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
444177002396	active site
444177002397	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
444177002398	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
444177002399	active site
444177002400	(T/H)XGH motif; other site
444177002401	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
444177002402	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
444177002403	transmembrane helices; other site
444177002404	TrkA-C domain; Region: TrkA_C; pfam02080
444177002405	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
444177002406	TrkA-C domain; Region: TrkA_C; pfam02080
444177002407	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
444177002408	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575
444177002409	active site
444177002410	dimer interface [polypeptide binding]; other site
444177002411	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
444177002412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177002413	putative substrate translocation pore; other site
444177002414	lysine transporter; Provisional; Region: PRK10836
444177002415	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177002416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177002417	active site
444177002418	phosphorylation site [posttranslational modification]
444177002419	intermolecular recognition site; other site
444177002420	dimerization interface [polypeptide binding]; other site
444177002421	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177002422	DNA binding site [nucleotide binding]
444177002423	fzo-like conserved region; Region: Fzo_mitofusin; pfam04799
444177002424	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177002425	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177002426	dimer interface [polypeptide binding]; other site
444177002427	phosphorylation site [posttranslational modification]
444177002428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177002429	ATP binding site [chemical binding]; other site
444177002430	Mg2+ binding site [ion binding]; other site
444177002431	G-X-G motif; other site
444177002432	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
444177002433	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
444177002434	Walker A/P-loop; other site
444177002435	ATP binding site [chemical binding]; other site
444177002436	Q-loop/lid; other site
444177002437	ABC transporter signature motif; other site
444177002438	Walker B; other site
444177002439	D-loop; other site
444177002440	H-loop/switch region; other site
444177002441	manganese transport protein MntH; Reviewed; Region: PRK00701
444177002442	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
444177002443	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177002444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177002445	active site
444177002446	phosphorylation site [posttranslational modification]
444177002447	intermolecular recognition site; other site
444177002448	dimerization interface [polypeptide binding]; other site
444177002449	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177002450	DNA binding site [nucleotide binding]
444177002451	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177002452	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
444177002453	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177002454	dimer interface [polypeptide binding]; other site
444177002455	phosphorylation site [posttranslational modification]
444177002456	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177002457	ATP binding site [chemical binding]; other site
444177002458	Mg2+ binding site [ion binding]; other site
444177002459	G-X-G motif; other site
444177002460	Predicted membrane protein [Function unknown]; Region: COG3212
444177002461	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
444177002462	Predicted membrane protein [Function unknown]; Region: COG3212
444177002463	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
444177002464	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
444177002465	Amino acid permease; Region: AA_permease_2; pfam13520
444177002466	K+ potassium transporter; Region: K_trans; cl15781
444177002467	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
444177002468	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
444177002469	active site
444177002470	xanthine permease; Region: pbuX; TIGR03173
444177002471	hypothetical protein; Provisional; Region: PRK04164
444177002472	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
444177002473	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
444177002474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
444177002475	Uncharacterized conserved protein [Function unknown]; Region: COG1284
444177002476	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
444177002477	EamA-like transporter family; Region: EamA; pfam00892
444177002478	EamA-like transporter family; Region: EamA; pfam00892
444177002479	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
444177002480	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
444177002481	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
444177002482	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
444177002483	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
444177002484	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
444177002485	hypothetical protein; Provisional; Region: PRK13660
444177002486	Predicted membrane protein [Function unknown]; Region: COG2311
444177002487	Protein of unknown function (DUF418); Region: DUF418; cl12135
444177002488	Protein of unknown function (DUF418); Region: DUF418; pfam04235
444177002489	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177002490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177002491	active site
444177002492	phosphorylation site [posttranslational modification]
444177002493	intermolecular recognition site; other site
444177002494	dimerization interface [polypeptide binding]; other site
444177002495	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177002496	DNA binding site [nucleotide binding]
444177002497	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177002498	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177002499	dimer interface [polypeptide binding]; other site
444177002500	phosphorylation site [posttranslational modification]
444177002501	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177002502	ATP binding site [chemical binding]; other site
444177002503	Mg2+ binding site [ion binding]; other site
444177002504	G-X-G motif; other site
444177002505	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177002506	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177002507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177002508	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177002509	putative substrate translocation pore; other site
444177002510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177002511	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
444177002512	Beta-lactamase; Region: Beta-lactamase; pfam00144
444177002513	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
444177002514	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
444177002515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177002516	dimer interface [polypeptide binding]; other site
444177002517	conserved gate region; other site
444177002518	putative PBP binding loops; other site
444177002519	ABC-ATPase subunit interface; other site
444177002520	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
444177002521	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177002522	dimer interface [polypeptide binding]; other site
444177002523	ABC-ATPase subunit interface; other site
444177002524	putative PBP binding loops; other site
444177002525	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
444177002526	nucleotide binding site [chemical binding]; other site
444177002527	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
444177002528	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
444177002529	putative active site [active]
444177002530	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
444177002531	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
444177002532	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
444177002533	putative active site [active]
444177002534	MMPL family; Region: MMPL; pfam03176
444177002535	MMPL family; Region: MMPL; pfam03176
444177002536	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177002537	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177002538	Uncharacterized conserved protein [Function unknown]; Region: COG2427
444177002539	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
444177002540	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
444177002541	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177002542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177002543	dimer interface [polypeptide binding]; other site
444177002544	putative CheW interface [polypeptide binding]; other site
444177002545	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
444177002546	putative metal binding site [ion binding]; other site
444177002547	putative dimer interface [polypeptide binding]; other site
444177002548	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
444177002549	Transcriptional regulator [Transcription]; Region: IclR; COG1414
444177002550	Bacterial transcriptional regulator; Region: IclR; pfam01614
444177002551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177002552	putative substrate translocation pore; other site
444177002553	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177002554	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
444177002555	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
444177002556	NADP binding site [chemical binding]; other site
444177002557	dimer interface [polypeptide binding]; other site
444177002558	EcsC protein family; Region: EcsC; pfam12787
444177002559	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
444177002560	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177002561	DNA-binding site [nucleotide binding]; DNA binding site
444177002562	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177002563	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177002564	homodimer interface [polypeptide binding]; other site
444177002565	catalytic residue [active]
444177002566	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177002567	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177002568	ATP-grasp domain; Region: ATP-grasp_4; cl17255
444177002569	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
444177002570	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
444177002571	Walker A/P-loop; other site
444177002572	ATP binding site [chemical binding]; other site
444177002573	Q-loop/lid; other site
444177002574	ABC transporter signature motif; other site
444177002575	Walker B; other site
444177002576	D-loop; other site
444177002577	H-loop/switch region; other site
444177002578	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177002579	ABC transporter signature motif; other site
444177002580	Walker B; other site
444177002581	D-loop; other site
444177002582	H-loop/switch region; other site
444177002583	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
444177002584	LytTr DNA-binding domain; Region: LytTR; pfam04397
444177002585	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
444177002586	S-layer homology domain; Region: SLH; pfam00395
444177002587	S-layer homology domain; Region: SLH; pfam00395
444177002588	S-layer homology domain; Region: SLH; pfam00395
444177002589	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
444177002590	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
444177002591	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177002592	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177002593	DEAD-like helicases superfamily; Region: DEXDc; smart00487
444177002594	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
444177002595	ATP binding site [chemical binding]; other site
444177002596	putative Mg++ binding site [ion binding]; other site
444177002597	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
444177002598	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177002599	nucleotide binding region [chemical binding]; other site
444177002600	ATP-binding site [chemical binding]; other site
444177002601	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
444177002602	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177002603	dimerization interface [polypeptide binding]; other site
444177002604	putative DNA binding site [nucleotide binding]; other site
444177002605	putative Zn2+ binding site [ion binding]; other site
444177002606	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
444177002607	putative hydrophobic ligand binding site [chemical binding]; other site
444177002608	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
444177002609	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177002610	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177002611	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
444177002612	putative dimerization interface [polypeptide binding]; other site
444177002613	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
444177002614	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
444177002615	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177002616	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
444177002617	active site
444177002618	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
444177002619	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177002620	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177002621	Coenzyme A binding pocket [chemical binding]; other site
444177002622	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
444177002623	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
444177002624	PhnA protein; Region: PhnA; pfam03831
444177002625	Putative zinc-finger; Region: zf-HC2; pfam13490
444177002626	HD domain; Region: HD_3; cl17350
444177002627	FtsX-like permease family; Region: FtsX; pfam02687
444177002628	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
444177002629	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
444177002630	Walker A/P-loop; other site
444177002631	ATP binding site [chemical binding]; other site
444177002632	Q-loop/lid; other site
444177002633	ABC transporter signature motif; other site
444177002634	Walker B; other site
444177002635	D-loop; other site
444177002636	H-loop/switch region; other site
444177002637	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177002638	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177002639	dimer interface [polypeptide binding]; other site
444177002640	phosphorylation site [posttranslational modification]
444177002641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177002642	ATP binding site [chemical binding]; other site
444177002643	Mg2+ binding site [ion binding]; other site
444177002644	G-X-G motif; other site
444177002645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177002646	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177002647	active site
444177002648	phosphorylation site [posttranslational modification]
444177002649	intermolecular recognition site; other site
444177002650	dimerization interface [polypeptide binding]; other site
444177002651	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177002652	DNA binding site [nucleotide binding]
444177002653	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177002654	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177002655	metal binding site [ion binding]; metal-binding site
444177002656	active site
444177002657	I-site; other site
444177002658	Response regulator receiver domain; Region: Response_reg; pfam00072
444177002659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177002660	active site
444177002661	phosphorylation site [posttranslational modification]
444177002662	intermolecular recognition site; other site
444177002663	dimerization interface [polypeptide binding]; other site
444177002664	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177002665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
444177002666	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
444177002667	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
444177002668	E-class dimer interface [polypeptide binding]; other site
444177002669	P-class dimer interface [polypeptide binding]; other site
444177002670	active site
444177002671	Cu2+ binding site [ion binding]; other site
444177002672	Zn2+ binding site [ion binding]; other site
444177002673	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
444177002674	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
444177002675	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
444177002676	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
444177002677	DctM-like transporters; Region: DctM; pfam06808
444177002678	M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018
444177002679	amidohydrolase; Region: amidohydrolases; TIGR01891
444177002680	metal binding site [ion binding]; metal-binding site
444177002681	putative dimer interface [polypeptide binding]; other site
444177002682	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
444177002683	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
444177002684	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
444177002685	active site
444177002686	Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114
444177002687	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
444177002688	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
444177002689	peptidase T; Region: peptidase-T; TIGR01882
444177002690	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
444177002691	metal binding site [ion binding]; metal-binding site
444177002692	dimer interface [polypeptide binding]; other site
444177002693	YhhN-like protein; Region: YhhN; pfam07947
444177002694	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
444177002695	dimer interface [polypeptide binding]; other site
444177002696	FMN binding site [chemical binding]; other site
444177002697	NADPH bind site [chemical binding]; other site
444177002698	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
444177002699	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
444177002700	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
444177002701	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
444177002702	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
444177002703	transmembrane helices; other site
444177002704	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
444177002705	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
444177002706	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
444177002707	homodimer interface [polypeptide binding]; other site
444177002708	substrate-cofactor binding pocket; other site
444177002709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177002710	catalytic residue [active]
444177002711	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
444177002712	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
444177002713	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
444177002714	Helix-turn-helix domain; Region: HTH_17; cl17695
444177002715	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
444177002716	EamA-like transporter family; Region: EamA; pfam00892
444177002717	EamA-like transporter family; Region: EamA; pfam00892
444177002718	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177002719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177002720	active site
444177002721	phosphorylation site [posttranslational modification]
444177002722	intermolecular recognition site; other site
444177002723	dimerization interface [polypeptide binding]; other site
444177002724	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177002725	DNA binding site [nucleotide binding]
444177002726	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177002727	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177002728	dimer interface [polypeptide binding]; other site
444177002729	phosphorylation site [posttranslational modification]
444177002730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177002731	ATP binding site [chemical binding]; other site
444177002732	Mg2+ binding site [ion binding]; other site
444177002733	G-X-G motif; other site
444177002734	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
444177002735	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
444177002736	active site
444177002737	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
444177002738	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
444177002739	putative active site [active]
444177002740	putative metal binding site [ion binding]; other site
444177002741	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
444177002742	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
444177002743	heme-binding site [chemical binding]; other site
444177002744	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177002745	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177002746	dimer interface [polypeptide binding]; other site
444177002747	putative CheW interface [polypeptide binding]; other site
444177002748	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
444177002749	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
444177002750	dimerization interface [polypeptide binding]; other site
444177002751	ligand binding site [chemical binding]; other site
444177002752	NADP binding site [chemical binding]; other site
444177002753	catalytic site [active]
444177002754	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
444177002755	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
444177002756	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
444177002757	NAD(P) binding site [chemical binding]; other site
444177002758	catalytic residues [active]
444177002759	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177002760	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
444177002761	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
444177002762	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
444177002763	active site
444177002764	Beta propeller domain; Region: Beta_propel; pfam09826
444177002765	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
444177002766	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
444177002767	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
444177002768	Uncharacterized conserved protein [Function unknown]; Region: COG2966
444177002769	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
444177002770	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
444177002771	PAS fold; Region: PAS; pfam00989
444177002772	PAS domain; Region: PAS_9; pfam13426
444177002773	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177002774	putative active site [active]
444177002775	heme pocket [chemical binding]; other site
444177002776	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177002777	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177002778	metal binding site [ion binding]; metal-binding site
444177002779	active site
444177002780	I-site; other site
444177002781	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
444177002782	EamA-like transporter family; Region: EamA; pfam00892
444177002783	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
444177002784	EamA-like transporter family; Region: EamA; pfam00892
444177002785	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
444177002786	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
444177002787	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177002788	Walker A/P-loop; other site
444177002789	ATP binding site [chemical binding]; other site
444177002790	Q-loop/lid; other site
444177002791	ABC transporter signature motif; other site
444177002792	Walker B; other site
444177002793	D-loop; other site
444177002794	H-loop/switch region; other site
444177002795	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
444177002796	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
444177002797	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177002798	Walker A/P-loop; other site
444177002799	ATP binding site [chemical binding]; other site
444177002800	Q-loop/lid; other site
444177002801	ABC transporter signature motif; other site
444177002802	Walker B; other site
444177002803	D-loop; other site
444177002804	H-loop/switch region; other site
444177002805	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
444177002806	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177002807	Coenzyme A binding pocket [chemical binding]; other site
444177002808	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177002809	Coenzyme A binding pocket [chemical binding]; other site
444177002810	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
444177002811	Part of AAA domain; Region: AAA_19; pfam13245
444177002812	Family description; Region: UvrD_C_2; pfam13538
444177002813	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
444177002814	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
444177002815	active site
444177002816	catalytic site [active]
444177002817	metal binding site [ion binding]; metal-binding site
444177002818	dimer interface [polypeptide binding]; other site
444177002819	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
444177002820	Putative amidase domain; Region: Amidase_6; pfam12671
444177002821	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
444177002822	putative FMN binding site [chemical binding]; other site
444177002823	hypothetical protein; Provisional; Region: PRK08201
444177002824	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
444177002825	metal binding site [ion binding]; metal-binding site
444177002826	putative dimer interface [polypeptide binding]; other site
444177002827	serine O-acetyltransferase; Region: cysE; TIGR01172
444177002828	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
444177002829	trimer interface [polypeptide binding]; other site
444177002830	active site
444177002831	substrate binding site [chemical binding]; other site
444177002832	CoA binding site [chemical binding]; other site
444177002833	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
444177002834	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177002835	NAD(P) binding site [chemical binding]; other site
444177002836	active site
444177002837	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
444177002838	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177002839	NAD(P) binding site [chemical binding]; other site
444177002840	active site
444177002841	GAF domain; Region: GAF_3; pfam13492
444177002842	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177002843	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
444177002844	DNA binding residues [nucleotide binding]
444177002845	dimerization interface [polypeptide binding]; other site
444177002846	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
444177002847	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177002848	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177002849	DNA binding residues [nucleotide binding]
444177002850	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177002851	MarR family; Region: MarR_2; pfam12802
444177002852	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
444177002853	ArsC family; Region: ArsC; pfam03960
444177002854	putative catalytic residues [active]
444177002855	thiol/disulfide switch; other site
444177002856	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
444177002857	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177002858	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177002859	Walker A/P-loop; other site
444177002860	ATP binding site [chemical binding]; other site
444177002861	Q-loop/lid; other site
444177002862	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177002863	ABC transporter signature motif; other site
444177002864	Walker B; other site
444177002865	D-loop; other site
444177002866	ABC transporter; Region: ABC_tran_2; pfam12848
444177002867	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177002868	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
444177002869	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
444177002870	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
444177002871	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
444177002872	NAD binding site [chemical binding]; other site
444177002873	active site
444177002874	Predicted flavoprotein [General function prediction only]; Region: COG0431
444177002875	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
444177002876	AAA domain; Region: AAA_11; pfam13086
444177002877	Part of AAA domain; Region: AAA_19; pfam13245
444177002878	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
444177002879	AAA domain; Region: AAA_12; pfam13087
444177002880	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
444177002881	putative metal binding site; other site
444177002882	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
444177002883	binding surface
444177002884	TPR motif; other site
444177002885	DNA topoisomerase III; Provisional; Region: PRK07726
444177002886	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
444177002887	active site
444177002888	putative interdomain interaction site [polypeptide binding]; other site
444177002889	putative metal-binding site [ion binding]; other site
444177002890	putative nucleotide binding site [chemical binding]; other site
444177002891	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
444177002892	domain I; other site
444177002893	DNA binding groove [nucleotide binding]
444177002894	phosphate binding site [ion binding]; other site
444177002895	domain II; other site
444177002896	domain III; other site
444177002897	nucleotide binding site [chemical binding]; other site
444177002898	catalytic site [active]
444177002899	domain IV; other site
444177002900	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
444177002901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177002902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177002903	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
444177002904	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
444177002905	FAD binding site [chemical binding]; other site
444177002906	homotetramer interface [polypeptide binding]; other site
444177002907	substrate binding pocket [chemical binding]; other site
444177002908	catalytic base [active]
444177002909	AMP-binding domain protein; Validated; Region: PRK08315
444177002910	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
444177002911	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
444177002912	acyl-activating enzyme (AAE) consensus motif; other site
444177002913	acyl-activating enzyme (AAE) consensus motif; other site
444177002914	putative AMP binding site [chemical binding]; other site
444177002915	putative active site [active]
444177002916	putative CoA binding site [chemical binding]; other site
444177002917	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
444177002918	ATP-grasp domain; Region: ATP-grasp_4; cl17255
444177002919	ATP-grasp domain; Region: ATP-grasp_4; cl17255
444177002920	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
444177002921	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
444177002922	carboxyltransferase (CT) interaction site; other site
444177002923	biotinylation site [posttranslational modification]; other site
444177002924	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
444177002925	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
444177002926	active site
444177002927	catalytic residues [active]
444177002928	metal binding site [ion binding]; metal-binding site
444177002929	enoyl-CoA hydratase; Provisional; Region: PRK07657
444177002930	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
444177002931	substrate binding site [chemical binding]; other site
444177002932	oxyanion hole (OAH) forming residues; other site
444177002933	trimer interface [polypeptide binding]; other site
444177002934	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
444177002935	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
444177002936	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
444177002937	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
444177002938	VanZ like family; Region: VanZ; pfam04892
444177002939	SprA-related family; Region: SprA-related; pfam12118
444177002940	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
444177002941	putative deacylase active site [active]
444177002942	Predicted membrane protein [Function unknown]; Region: COG2364
444177002943	hypothetical protein; Provisional; Region: PRK06851
444177002944	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
444177002945	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
444177002946	substrate-cofactor binding pocket; other site
444177002947	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177002948	catalytic residue [active]
444177002949	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
444177002950	CoA-transferase family III; Region: CoA_transf_3; pfam02515
444177002951	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
444177002952	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
444177002953	phosphate binding site [ion binding]; other site
444177002954	enoyl-CoA hydratase; Provisional; Region: PRK06127
444177002955	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
444177002956	substrate binding site [chemical binding]; other site
444177002957	oxyanion hole (OAH) forming residues; other site
444177002958	trimer interface [polypeptide binding]; other site
444177002959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177002960	ABC-ATPase subunit interface; other site
444177002961	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
444177002962	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
444177002963	Walker A/P-loop; other site
444177002964	ATP binding site [chemical binding]; other site
444177002965	Q-loop/lid; other site
444177002966	ABC transporter signature motif; other site
444177002967	Walker B; other site
444177002968	D-loop; other site
444177002969	H-loop/switch region; other site
444177002970	NIL domain; Region: NIL; pfam09383
444177002971	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
444177002972	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
444177002973	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
444177002974	trimer interface [polypeptide binding]; other site
444177002975	putative Zn binding site [ion binding]; other site
444177002976	transaminase; Reviewed; Region: PRK08068
444177002977	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177002978	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177002979	homodimer interface [polypeptide binding]; other site
444177002980	catalytic residue [active]
444177002981	Predicted amidohydrolase [General function prediction only]; Region: COG0388
444177002982	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
444177002983	putative active site [active]
444177002984	catalytic triad [active]
444177002985	putative dimer interface [polypeptide binding]; other site
444177002986	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
444177002987	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
444177002988	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
444177002989	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
444177002990	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
444177002991	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
444177002992	tetrameric interface [polypeptide binding]; other site
444177002993	NAD binding site [chemical binding]; other site
444177002994	catalytic residues [active]
444177002995	aminotransferase; Validated; Region: PRK07678
444177002996	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
444177002997	inhibitor-cofactor binding pocket; inhibition site
444177002998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177002999	catalytic residue [active]
444177003000	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
444177003001	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
444177003002	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
444177003003	HAMP domain; Region: HAMP; pfam00672
444177003004	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177003005	dimer interface [polypeptide binding]; other site
444177003006	putative CheW interface [polypeptide binding]; other site
444177003007	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
444177003008	L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272
444177003009	NAD binding site [chemical binding]; other site
444177003010	homodimer interface [polypeptide binding]; other site
444177003011	active site
444177003012	putative substrate binding site [chemical binding]; other site
444177003013	QueT transporter; Region: QueT; pfam06177
444177003014	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
444177003015	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
444177003016	zinc binding site [ion binding]; other site
444177003017	putative ligand binding site [chemical binding]; other site
444177003018	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
444177003019	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
444177003020	TM-ABC transporter signature motif; other site
444177003021	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
444177003022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177003023	Walker A/P-loop; other site
444177003024	ATP binding site [chemical binding]; other site
444177003025	Q-loop/lid; other site
444177003026	ABC transporter signature motif; other site
444177003027	Walker B; other site
444177003028	D-loop; other site
444177003029	H-loop/switch region; other site
444177003030	threonine dehydratase; Validated; Region: PRK08639
444177003031	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
444177003032	tetramer interface [polypeptide binding]; other site
444177003033	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177003034	catalytic residue [active]
444177003035	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
444177003036	putative Ile/Val binding site [chemical binding]; other site
444177003037	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
444177003038	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
444177003039	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
444177003040	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
444177003041	dimer interface [polypeptide binding]; other site
444177003042	substrate binding site [chemical binding]; other site
444177003043	ATP binding site [chemical binding]; other site
444177003044	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
444177003045	ligand binding site [chemical binding]; other site
444177003046	active site
444177003047	UGI interface [polypeptide binding]; other site
444177003048	catalytic site [active]
444177003049	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
444177003050	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
444177003051	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
444177003052	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
444177003053	metal binding site [ion binding]; metal-binding site
444177003054	dimer interface [polypeptide binding]; other site
444177003055	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881
444177003056	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
444177003057	putative heme peroxidase; Provisional; Region: PRK12276
444177003058	Chlorite dismutase; Region: Chlor_dismutase; cl01280
444177003059	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
444177003060	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
444177003061	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
444177003062	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
444177003063	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
444177003064	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177003065	Zn2+ binding site [ion binding]; other site
444177003066	Mg2+ binding site [ion binding]; other site
444177003067	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
444177003068	Collagen binding domain; Region: Collagen_bind; pfam05737
444177003069	Collagen binding domain; Region: Collagen_bind; pfam05737
444177003070	Collagen binding domain; Region: Collagen_bind; pfam05737
444177003071	Cna protein B-type domain; Region: Cna_B; pfam05738
444177003072	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
444177003073	active site
444177003074	catalytic site [active]
444177003075	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
444177003076	active site 1 [active]
444177003077	dimer interface [polypeptide binding]; other site
444177003078	hexamer interface [polypeptide binding]; other site
444177003079	active site 2 [active]
444177003080	YwhD family; Region: YwhD; pfam08741
444177003081	Transglycosylase; Region: Transgly; pfam00912
444177003082	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
444177003083	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
444177003084	agmatinase; Region: agmatinase; TIGR01230
444177003085	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
444177003086	putative active site [active]
444177003087	Mn binding site [ion binding]; other site
444177003088	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
444177003089	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
444177003090	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
444177003091	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
444177003092	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
444177003093	active site
444177003094	HIGH motif; other site
444177003095	KMSK motif region; other site
444177003096	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
444177003097	tRNA binding surface [nucleotide binding]; other site
444177003098	anticodon binding site; other site
444177003099	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
444177003100	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
444177003101	DNA binding residues [nucleotide binding]
444177003102	putative dimer interface [polypeptide binding]; other site
444177003103	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
444177003104	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
444177003105	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
444177003106	acyl-activating enzyme (AAE) consensus motif; other site
444177003107	putative AMP binding site [chemical binding]; other site
444177003108	putative active site [active]
444177003109	putative CoA binding site [chemical binding]; other site
444177003110	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
444177003111	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
444177003112	active site
444177003113	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177003114	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
444177003115	putative binding site residues; other site
444177003116	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
444177003117	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177003118	dimer interface [polypeptide binding]; other site
444177003119	ABC-ATPase subunit  interface; other site
444177003120	putative PBP binding regions; other site
444177003121	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
444177003122	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
444177003123	Walker A/P-loop; other site
444177003124	ATP binding site [chemical binding]; other site
444177003125	Q-loop/lid; other site
444177003126	ABC transporter signature motif; other site
444177003127	Walker B; other site
444177003128	D-loop; other site
444177003129	H-loop/switch region; other site
444177003130	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
444177003131	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
444177003132	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
444177003133	Cysteine-rich domain; Region: CCG; pfam02754
444177003134	Cysteine-rich domain; Region: CCG; pfam02754
444177003135	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
444177003136	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
444177003137	dimer interface [polypeptide binding]; other site
444177003138	active site
444177003139	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
444177003140	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
444177003141	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
444177003142	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
444177003143	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
444177003144	FAD binding site [chemical binding]; other site
444177003145	homotetramer interface [polypeptide binding]; other site
444177003146	substrate binding pocket [chemical binding]; other site
444177003147	catalytic base [active]
444177003148	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
444177003149	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
444177003150	FAD binding site [chemical binding]; other site
444177003151	homotetramer interface [polypeptide binding]; other site
444177003152	substrate binding pocket [chemical binding]; other site
444177003153	catalytic base [active]
444177003154	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177003155	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177003156	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
444177003157	B12 binding site [chemical binding]; other site
444177003158	cobalt ligand [ion binding]; other site
444177003159	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
444177003160	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
444177003161	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
444177003162	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
444177003163	CTP synthetase; Validated; Region: pyrG; PRK05380
444177003164	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
444177003165	Catalytic site [active]
444177003166	active site
444177003167	UTP binding site [chemical binding]; other site
444177003168	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
444177003169	active site
444177003170	putative oxyanion hole; other site
444177003171	catalytic triad [active]
444177003172	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
444177003173	Response regulator receiver domain; Region: Response_reg; pfam00072
444177003174	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177003175	active site
444177003176	phosphorylation site [posttranslational modification]
444177003177	intermolecular recognition site; other site
444177003178	dimerization interface [polypeptide binding]; other site
444177003179	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
444177003180	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
444177003181	intersubunit interface [polypeptide binding]; other site
444177003182	active site
444177003183	zinc binding site [ion binding]; other site
444177003184	Na+ binding site [ion binding]; other site
444177003185	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
444177003186	active site
444177003187	intersubunit interactions; other site
444177003188	catalytic residue [active]
444177003189	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
444177003190	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
444177003191	hinge; other site
444177003192	active site
444177003193	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
444177003194	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
444177003195	putative active site [active]
444177003196	transcription termination factor Rho; Provisional; Region: rho; PRK09376
444177003197	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
444177003198	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
444177003199	RNA binding site [nucleotide binding]; other site
444177003200	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
444177003201	multimer interface [polypeptide binding]; other site
444177003202	Walker A motif; other site
444177003203	ATP binding site [chemical binding]; other site
444177003204	Walker B motif; other site
444177003205	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177003206	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177003207	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177003208	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177003209	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177003210	intersubunit interface [polypeptide binding]; other site
444177003211	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
444177003212	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
444177003213	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
444177003214	Walker A/P-loop; other site
444177003215	ATP binding site [chemical binding]; other site
444177003216	Q-loop/lid; other site
444177003217	ABC transporter signature motif; other site
444177003218	Walker B; other site
444177003219	D-loop; other site
444177003220	H-loop/switch region; other site
444177003221	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
444177003222	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
444177003223	Walker A/P-loop; other site
444177003224	ATP binding site [chemical binding]; other site
444177003225	Q-loop/lid; other site
444177003226	ABC transporter signature motif; other site
444177003227	Walker B; other site
444177003228	D-loop; other site
444177003229	H-loop/switch region; other site
444177003230	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
444177003231	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177003232	ABC-ATPase subunit  interface; other site
444177003233	dimer interface [polypeptide binding]; other site
444177003234	putative PBP binding regions; other site
444177003235	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
444177003236	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177003237	ABC-ATPase subunit  interface; other site
444177003238	dimer interface [polypeptide binding]; other site
444177003239	putative PBP binding regions; other site
444177003240	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
444177003241	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
444177003242	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
444177003243	thymidine kinase; Provisional; Region: PRK04296
444177003244	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
444177003245	ATP binding site [chemical binding]; other site
444177003246	Walker A motif; other site
444177003247	Walker B motif; other site
444177003248	peptide chain release factor 1; Validated; Region: prfA; PRK00591
444177003249	This domain is found in peptide chain release factors; Region: PCRF; smart00937
444177003250	RF-1 domain; Region: RF-1; pfam00472
444177003251	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
444177003252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177003253	S-adenosylmethionine binding site [chemical binding]; other site
444177003254	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
444177003255	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775
444177003256	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
444177003257	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
444177003258	Predicted membrane protein [Function unknown]; Region: COG1971
444177003259	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
444177003260	Low molecular weight phosphatase family; Region: LMWPc; cl00105
444177003261	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
444177003262	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177003263	dimerization interface [polypeptide binding]; other site
444177003264	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177003265	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177003266	dimer interface [polypeptide binding]; other site
444177003267	putative CheW interface [polypeptide binding]; other site
444177003268	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
444177003269	hypothetical protein; Provisional; Region: PRK13690
444177003270	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
444177003271	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
444177003272	dimer interface [polypeptide binding]; other site
444177003273	active site
444177003274	glycine-pyridoxal phosphate binding site [chemical binding]; other site
444177003275	folate binding site [chemical binding]; other site
444177003276	PAS domain; Region: PAS_9; pfam13426
444177003277	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177003278	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177003279	metal binding site [ion binding]; metal-binding site
444177003280	active site
444177003281	I-site; other site
444177003282	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
444177003283	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
444177003284	active site
444177003285	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
444177003286	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
444177003287	active site
444177003288	homodimer interface [polypeptide binding]; other site
444177003289	ATP synthase I chain; Region: ATP_synt_I; pfam03899
444177003290	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
444177003291	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
444177003292	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
444177003293	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
444177003294	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
444177003295	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
444177003296	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
444177003297	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
444177003298	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
444177003299	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
444177003300	beta subunit interaction interface [polypeptide binding]; other site
444177003301	Walker A motif; other site
444177003302	ATP binding site [chemical binding]; other site
444177003303	Walker B motif; other site
444177003304	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
444177003305	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
444177003306	core domain interface [polypeptide binding]; other site
444177003307	delta subunit interface [polypeptide binding]; other site
444177003308	epsilon subunit interface [polypeptide binding]; other site
444177003309	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
444177003310	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
444177003311	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
444177003312	alpha subunit interaction interface [polypeptide binding]; other site
444177003313	Walker A motif; other site
444177003314	ATP binding site [chemical binding]; other site
444177003315	Walker B motif; other site
444177003316	inhibitor binding site; inhibition site
444177003317	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
444177003318	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
444177003319	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
444177003320	LBP interface [polypeptide binding]; other site
444177003321	epsilon subunit interface [polypeptide binding]; other site
444177003322	gamma subunit interface [polypeptide binding]; other site
444177003323	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
444177003324	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
444177003325	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
444177003326	hinge; other site
444177003327	active site
444177003328	Stage II sporulation protein; Region: SpoIID; pfam08486
444177003329	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
444177003330	Peptidase family M23; Region: Peptidase_M23; pfam01551
444177003331	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
444177003332	Stage III sporulation protein D; Region: SpoIIID; cl17560
444177003333	rod shape-determining protein Mbl; Provisional; Region: PRK13928
444177003334	MreB and similar proteins; Region: MreB_like; cd10225
444177003335	nucleotide binding site [chemical binding]; other site
444177003336	Mg binding site [ion binding]; other site
444177003337	putative protofilament interaction site [polypeptide binding]; other site
444177003338	RodZ interaction site [polypeptide binding]; other site
444177003339	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
444177003340	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
444177003341	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
444177003342	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
444177003343	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
444177003344	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
444177003345	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
444177003346	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
444177003347	YwpF-like protein; Region: YwpF; pfam14183
444177003348	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
444177003349	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
444177003350	dimer interface [polypeptide binding]; other site
444177003351	ssDNA binding site [nucleotide binding]; other site
444177003352	tetramer (dimer of dimers) interface [polypeptide binding]; other site
444177003353	SNF2 Helicase protein; Region: DUF3670; pfam12419
444177003354	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
444177003355	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
444177003356	ATP binding site [chemical binding]; other site
444177003357	putative Mg++ binding site [ion binding]; other site
444177003358	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177003359	nucleotide binding region [chemical binding]; other site
444177003360	ATP-binding site [chemical binding]; other site
444177003361	flagellin; Provisional; Region: PRK12804
444177003362	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
444177003363	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
444177003364	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
444177003365	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
444177003366	stage V sporulation protein B; Region: spore_V_B; TIGR02900
444177003367	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
444177003368	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
444177003369	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
444177003370	S-layer homology domain; Region: SLH; pfam00395
444177003371	S-layer homology domain; Region: SLH; pfam00395
444177003372	S-layer homology domain; Region: SLH; pfam00395
444177003373	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
444177003374	Bacterial SH3 domain; Region: SH3_3; pfam08239
444177003375	Bacterial SH3 domain; Region: SH3_3; pfam08239
444177003376	S-layer homology domain; Region: SLH; pfam00395
444177003377	S-layer homology domain; Region: SLH; pfam00395
444177003378	S-layer homology domain; Region: SLH; pfam00395
444177003379	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
444177003380	HTH-like domain; Region: HTH_21; pfam13276
444177003381	Integrase core domain; Region: rve; pfam00665
444177003382	Integrase core domain; Region: rve_2; pfam13333
444177003383	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
444177003384	Helix-turn-helix domain; Region: HTH_28; pfam13518
444177003385	Winged helix-turn helix; Region: HTH_29; pfam13551
444177003386	TGF-beta propeptide; Region: TGFb_propeptide; pfam00688
444177003387	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
444177003388	RHS Repeat; Region: RHS_repeat; pfam05593
444177003389	RHS protein; Region: RHS; pfam03527
444177003390	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
444177003391	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
444177003392	quinone binding site; other site
444177003393	Fe binding site [ion binding]; other site
444177003394	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
444177003395	RHS Repeat; Region: RHS_repeat; cl11982
444177003396	RHS protein; Region: RHS; pfam03527
444177003397	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
444177003398	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
444177003399	HTH-like domain; Region: HTH_21; pfam13276
444177003400	Integrase core domain; Region: rve; pfam00665
444177003401	Integrase core domain; Region: rve_2; pfam13333
444177003402	Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318
444177003403	Helix-turn-helix domain; Region: HTH_28; pfam13518
444177003404	HTH-like domain; Region: HTH_21; pfam13276
444177003405	Cache domain; Region: Cache_1; pfam02743
444177003406	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
444177003407	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177003408	dimerization interface [polypeptide binding]; other site
444177003409	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177003410	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177003411	metal binding site [ion binding]; metal-binding site
444177003412	active site
444177003413	I-site; other site
444177003414	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
444177003415	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
444177003416	HTH domain; Region: HTH_11; pfam08279
444177003417	Mga helix-turn-helix domain; Region: Mga; pfam05043
444177003418	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
444177003419	active site
444177003420	P-loop; other site
444177003421	phosphorylation site [posttranslational modification]
444177003422	Helix-turn-helix domain; Region: HTH_19; pfam12844
444177003423	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
444177003424	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
444177003425	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177003426	dimerization interface [polypeptide binding]; other site
444177003427	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177003428	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177003429	dimer interface [polypeptide binding]; other site
444177003430	putative CheW interface [polypeptide binding]; other site
444177003431	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
444177003432	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
444177003433	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177003434	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177003435	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177003436	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177003437	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
444177003438	active site
444177003439	DNA binding site [nucleotide binding]
444177003440	Int/Topo IB signature motif; other site
444177003441	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177003442	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
444177003443	active site
444177003444	DNA binding site [nucleotide binding]
444177003445	Int/Topo IB signature motif; other site
444177003446	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177003447	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177003448	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
444177003449	active site
444177003450	DNA binding site [nucleotide binding]
444177003451	Int/Topo IB signature motif; other site
444177003452	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
444177003453	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177003454	active site
444177003455	DNA binding site [nucleotide binding]
444177003456	Int/Topo IB signature motif; other site
444177003457	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
444177003458	sequence-specific DNA binding site [nucleotide binding]; other site
444177003459	salt bridge; other site
444177003460	Phage-related protein [Function unknown]; Region: COG5412
444177003461	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
444177003462	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177003463	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177003464	DNA binding residues [nucleotide binding]
444177003465	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
444177003466	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177003467	active site
444177003468	DNA binding site [nucleotide binding]
444177003469	Int/Topo IB signature motif; other site
444177003470	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316
444177003471	Bacterial Ig-like domain; Region: Big_5; pfam13205
444177003472	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177003473	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177003474	Cache domain; Region: Cache_1; pfam02743
444177003475	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177003476	dimerization interface [polypeptide binding]; other site
444177003477	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177003478	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177003479	dimer interface [polypeptide binding]; other site
444177003480	putative CheW interface [polypeptide binding]; other site
444177003481	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
444177003482	Integrase core domain; Region: rve; pfam00665
444177003483	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
444177003484	active site
444177003485	catalytic site [active]
444177003486	putative metal binding site [ion binding]; other site
444177003487	Fic family protein [Function unknown]; Region: COG3177
444177003488	Fic/DOC family; Region: Fic; pfam02661
444177003489	Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318
444177003490	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177003491	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177003492	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177003493	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
444177003494	S-layer homology domain; Region: SLH; pfam00395
444177003495	S-layer homology domain; Region: SLH; pfam00395
444177003496	S-layer homology domain; Region: SLH; pfam00395
444177003497	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
444177003498	S-layer homology domain; Region: SLH; pfam00395
444177003499	S-layer homology domain; Region: SLH; pfam00395
444177003500	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
444177003501	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
444177003502	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
444177003503	NlpC/P60 family; Region: NLPC_P60; pfam00877
444177003504	S-layer homology domain; Region: SLH; pfam00395
444177003505	S-layer homology domain; Region: SLH; pfam00395
444177003506	S-layer homology domain; Region: SLH; pfam00395
444177003507	S-layer homology domain; Region: SLH; pfam00395
444177003508	Bacterial SH3 domain; Region: SH3_3; pfam08239
444177003509	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
444177003510	Bacterial SH3 domain; Region: SH3_3; pfam08239
444177003511	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
444177003512	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
444177003513	active site
444177003514	metal binding site [ion binding]; metal-binding site
444177003515	S-layer homology domain; Region: SLH; pfam00395
444177003516	S-layer homology domain; Region: SLH; pfam00395
444177003517	S-layer homology domain; Region: SLH; pfam00395
444177003518	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
444177003519	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
444177003520	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
444177003521	catalytic residues [active]
444177003522	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
444177003523	PAS fold; Region: PAS_4; pfam08448
444177003524	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
444177003525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177003526	Walker A motif; other site
444177003527	ATP binding site [chemical binding]; other site
444177003528	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
444177003529	Proline dehydrogenase; Region: Pro_dh; cl03282
444177003530	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177003531	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177003532	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
444177003533	C-terminal peptidase (prc); Region: prc; TIGR00225
444177003534	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
444177003535	protein binding site [polypeptide binding]; other site
444177003536	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
444177003537	Catalytic dyad [active]
444177003538	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
444177003539	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
444177003540	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177003541	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177003542	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
444177003543	NlpC/P60 family; Region: NLPC_P60; pfam00877
444177003544	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
444177003545	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
444177003546	nucleotide binding region [chemical binding]; other site
444177003547	helicase superfamily c-terminal domain; Region: HELICc; smart00490
444177003548	ATP-binding site [chemical binding]; other site
444177003549	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
444177003550	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
444177003551	Mg++ binding site [ion binding]; other site
444177003552	putative catalytic motif [active]
444177003553	substrate binding site [chemical binding]; other site
444177003554	Transcriptional regulator [Transcription]; Region: LytR; COG1316
444177003555	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
444177003556	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
444177003557	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
444177003558	Sensor protein DegS; Region: DegS; pfam05384
444177003559	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
444177003560	Histidine kinase; Region: HisKA_3; pfam07730
444177003561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177003562	ATP binding site [chemical binding]; other site
444177003563	Mg2+ binding site [ion binding]; other site
444177003564	G-X-G motif; other site
444177003565	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177003566	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177003567	active site
444177003568	phosphorylation site [posttranslational modification]
444177003569	intermolecular recognition site; other site
444177003570	dimerization interface [polypeptide binding]; other site
444177003571	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
444177003572	DNA binding residues [nucleotide binding]
444177003573	dimerization interface [polypeptide binding]; other site
444177003574	EDD domain protein, DegV family; Region: DegV; TIGR00762
444177003575	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
444177003576	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
444177003577	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
444177003578	ATP binding site [chemical binding]; other site
444177003579	putative Mg++ binding site [ion binding]; other site
444177003580	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177003581	nucleotide binding region [chemical binding]; other site
444177003582	ATP-binding site [chemical binding]; other site
444177003583	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
444177003584	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
444177003585	active site
444177003586	flagellar operon protein TIGR03826; Region: YvyF
444177003587	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
444177003588	FlgN protein; Region: FlgN; pfam05130
444177003589	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
444177003590	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
444177003591	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
444177003592	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
444177003593	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
444177003594	flagellar assembly protein FliW; Provisional; Region: PRK13285
444177003595	carbon storage regulator; Provisional; Region: PRK01712
444177003596	flagellin; Provisional; Region: PRK12804
444177003597	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
444177003598	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
444177003599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
444177003600	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
444177003601	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
444177003602	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
444177003603	NAD binding site [chemical binding]; other site
444177003604	substrate binding site [chemical binding]; other site
444177003605	active site
444177003606	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
444177003607	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
444177003608	inhibitor-cofactor binding pocket; inhibition site
444177003609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177003610	catalytic residue [active]
444177003611	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
444177003612	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
444177003613	active site
444177003614	homodimer interface [polypeptide binding]; other site
444177003615	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
444177003616	NeuB family; Region: NeuB; pfam03102
444177003617	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
444177003618	NeuB binding interface [polypeptide binding]; other site
444177003619	putative substrate binding site [chemical binding]; other site
444177003620	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
444177003621	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
444177003622	putative trimer interface [polypeptide binding]; other site
444177003623	putative CoA binding site [chemical binding]; other site
444177003624	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
444177003625	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
444177003626	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
444177003627	Substrate binding site; other site
444177003628	metal-binding site
444177003629	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
444177003630	ligand binding site; other site
444177003631	tetramer interface; other site
444177003632	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177003633	S-adenosylmethionine binding site [chemical binding]; other site
444177003634	Sulfatase; Region: Sulfatase; cl17466
444177003635	FlaG protein; Region: FlaG; cl00591
444177003636	flagellar capping protein; Validated; Region: fliD; PRK07737
444177003637	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
444177003638	Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951
444177003639	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
444177003640	Flagellar protein FliT; Region: FliT; pfam05400
444177003641	flagellar protein FliS; Validated; Region: fliS; PRK05685
444177003642	PilZ domain; Region: PilZ; pfam07238
444177003643	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
444177003644	30S subunit binding site; other site
444177003645	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
444177003646	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
444177003647	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
444177003648	nucleotide binding region [chemical binding]; other site
444177003649	ATP-binding site [chemical binding]; other site
444177003650	SEC-C motif; Region: SEC-C; pfam02810
444177003651	ComK protein; Region: ComK; pfam06338
444177003652	peptide chain release factor 2; Provisional; Region: PRK06746
444177003653	This domain is found in peptide chain release factors; Region: PCRF; smart00937
444177003654	RF-1 domain; Region: RF-1; pfam00472
444177003655	ComK protein; Region: ComK; cl11560
444177003656	IDEAL domain; Region: IDEAL; cl07452
444177003657	excinuclease ABC subunit B; Provisional; Region: PRK05298
444177003658	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
444177003659	ATP binding site [chemical binding]; other site
444177003660	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177003661	nucleotide binding region [chemical binding]; other site
444177003662	ATP-binding site [chemical binding]; other site
444177003663	Ultra-violet resistance protein B; Region: UvrB; pfam12344
444177003664	UvrB/uvrC motif; Region: UVR; pfam02151
444177003665	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
444177003666	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
444177003667	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
444177003668	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
444177003669	Uncharacterized conserved protein [Function unknown]; Region: COG3595
444177003670	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
444177003671	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
444177003672	ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292
444177003673	Walker A/P-loop; other site
444177003674	ATP binding site [chemical binding]; other site
444177003675	Q-loop/lid; other site
444177003676	ABC transporter signature motif; other site
444177003677	Walker B; other site
444177003678	D-loop; other site
444177003679	H-loop/switch region; other site
444177003680	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
444177003681	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
444177003682	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
444177003683	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
444177003684	Peptidase family M23; Region: Peptidase_M23; pfam01551
444177003685	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
444177003686	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
444177003687	catalytic residues [active]
444177003688	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
444177003689	C-terminal peptidase (prc); Region: prc; TIGR00225
444177003690	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
444177003691	protein binding site [polypeptide binding]; other site
444177003692	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
444177003693	Catalytic dyad [active]
444177003694	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
444177003695	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
444177003696	Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559
444177003697	Predicted membrane protein [Function unknown]; Region: COG4392
444177003698	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
444177003699	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
444177003700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177003701	non-specific DNA binding site [nucleotide binding]; other site
444177003702	salt bridge; other site
444177003703	sequence-specific DNA binding site [nucleotide binding]; other site
444177003704	Cupin domain; Region: Cupin_2; pfam07883
444177003705	Uncharacterized conserved protein [Function unknown]; Region: COG0398
444177003706	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
444177003707	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
444177003708	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
444177003709	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
444177003710	Part of AAA domain; Region: AAA_19; pfam13245
444177003711	Family description; Region: UvrD_C_2; pfam13538
444177003712	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
444177003713	Predicted membrane protein [Function unknown]; Region: COG2311
444177003714	Protein of unknown function (DUF418); Region: DUF418; cl12135
444177003715	Protein of unknown function (DUF418); Region: DUF418; pfam04235
444177003716	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
444177003717	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
444177003718	hypothetical protein; Provisional; Region: PRK13673
444177003719	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
444177003720	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
444177003721	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
444177003722	active site
444177003723	catalytic site [active]
444177003724	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
444177003725	EDD domain protein, DegV family; Region: DegV; TIGR00762
444177003726	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
444177003727	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
444177003728	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177003729	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
444177003730	motif I; other site
444177003731	active site
444177003732	esterase; Provisional; Region: PRK10566
444177003733	Secretory lipase; Region: LIP; pfam03583
444177003734	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
444177003735	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
444177003736	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
444177003737	ligand binding site [chemical binding]; other site
444177003738	flexible hinge region; other site
444177003739	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
444177003740	putative switch regulator; other site
444177003741	non-specific DNA interactions [nucleotide binding]; other site
444177003742	DNA binding site [nucleotide binding]
444177003743	sequence specific DNA binding site [nucleotide binding]; other site
444177003744	putative cAMP binding site [chemical binding]; other site
444177003745	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177003746	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
444177003747	Walker A motif; other site
444177003748	ATP binding site [chemical binding]; other site
444177003749	Walker B motif; other site
444177003750	arginine finger; other site
444177003751	Integral membrane protein DUF106; Region: DUF106; pfam01956
444177003752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177003753	Walker A motif; other site
444177003754	ATP binding site [chemical binding]; other site
444177003755	Walker B motif; other site
444177003756	arginine finger; other site
444177003757	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
444177003758	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
444177003759	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
444177003760	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
444177003761	dimer interface [polypeptide binding]; other site
444177003762	active site
444177003763	CoA binding pocket [chemical binding]; other site
444177003764	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
444177003765	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
444177003766	dimer interface [polypeptide binding]; other site
444177003767	active site
444177003768	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
444177003769	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
444177003770	active site
444177003771	HIGH motif; other site
444177003772	dimer interface [polypeptide binding]; other site
444177003773	KMSKS motif; other site
444177003774	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
444177003775	ArsC family; Region: ArsC; pfam03960
444177003776	putative catalytic residues [active]
444177003777	thiol/disulfide switch; other site
444177003778	adaptor protein; Provisional; Region: PRK02315
444177003779	Competence protein CoiA-like family; Region: CoiA; cl11541
444177003780	oligoendopeptidase F; Region: pepF; TIGR00181
444177003781	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
444177003782	active site
444177003783	Zn binding site [ion binding]; other site
444177003784	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
444177003785	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
444177003786	catalytic residues [active]
444177003787	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
444177003788	apolar tunnel; other site
444177003789	heme binding site [chemical binding]; other site
444177003790	dimerization interface [polypeptide binding]; other site
444177003791	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
444177003792	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
444177003793	N-acetyl-D-glucosamine binding site [chemical binding]; other site
444177003794	catalytic residue [active]
444177003795	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
444177003796	putative active site [active]
444177003797	putative metal binding residues [ion binding]; other site
444177003798	signature motif; other site
444177003799	putative triphosphate binding site [ion binding]; other site
444177003800	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
444177003801	synthetase active site [active]
444177003802	NTP binding site [chemical binding]; other site
444177003803	metal binding site [ion binding]; metal-binding site
444177003804	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
444177003805	ATP-NAD kinase; Region: NAD_kinase; pfam01513
444177003806	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
444177003807	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
444177003808	active site
444177003809	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
444177003810	MgtE intracellular N domain; Region: MgtE_N; pfam03448
444177003811	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
444177003812	Divalent cation transporter; Region: MgtE; pfam01769
444177003813	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
444177003814	SpoVA protein; Region: SpoVA; cl04298
444177003815	stage V sporulation protein AD; Provisional; Region: PRK12404
444177003816	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
444177003817	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
444177003818	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
444177003819	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
444177003820	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177003821	Coenzyme A binding pocket [chemical binding]; other site
444177003822	hypothetical protein; Provisional; Region: PRK13679
444177003823	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
444177003824	Putative esterase; Region: Esterase; pfam00756
444177003825	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
444177003826	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
444177003827	tetramer interfaces [polypeptide binding]; other site
444177003828	binuclear metal-binding site [ion binding]; other site
444177003829	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
444177003830	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
444177003831	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
444177003832	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
444177003833	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
444177003834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177003835	dimer interface [polypeptide binding]; other site
444177003836	conserved gate region; other site
444177003837	putative PBP binding loops; other site
444177003838	ABC-ATPase subunit interface; other site
444177003839	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177003840	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177003841	dimer interface [polypeptide binding]; other site
444177003842	conserved gate region; other site
444177003843	putative PBP binding loops; other site
444177003844	ABC-ATPase subunit interface; other site
444177003845	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
444177003846	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177003847	Walker A/P-loop; other site
444177003848	ATP binding site [chemical binding]; other site
444177003849	Q-loop/lid; other site
444177003850	ABC transporter signature motif; other site
444177003851	Walker B; other site
444177003852	D-loop; other site
444177003853	H-loop/switch region; other site
444177003854	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
444177003855	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177003856	Walker A/P-loop; other site
444177003857	ATP binding site [chemical binding]; other site
444177003858	Q-loop/lid; other site
444177003859	ABC transporter signature motif; other site
444177003860	Walker B; other site
444177003861	D-loop; other site
444177003862	H-loop/switch region; other site
444177003863	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
444177003864	Staphylococcal nuclease homologues; Region: SNc; smart00318
444177003865	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
444177003866	Catalytic site; other site
444177003867	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
444177003868	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
444177003869	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
444177003870	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
444177003871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177003872	dimer interface [polypeptide binding]; other site
444177003873	conserved gate region; other site
444177003874	ABC-ATPase subunit interface; other site
444177003875	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
444177003876	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177003877	dimer interface [polypeptide binding]; other site
444177003878	conserved gate region; other site
444177003879	putative PBP binding loops; other site
444177003880	ABC-ATPase subunit interface; other site
444177003881	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
444177003882	Protein of unknown function, DUF624; Region: DUF624; cl02369
444177003883	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
444177003884	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
444177003885	active site
444177003886	dimer interface [polypeptide binding]; other site
444177003887	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
444177003888	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177003889	DNA-binding site [nucleotide binding]; DNA binding site
444177003890	UTRA domain; Region: UTRA; pfam07702
444177003891	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
444177003892	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
444177003893	intersubunit interface [polypeptide binding]; other site
444177003894	active site
444177003895	zinc binding site [ion binding]; other site
444177003896	Na+ binding site [ion binding]; other site
444177003897	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
444177003898	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
444177003899	putative substrate binding site [chemical binding]; other site
444177003900	putative ATP binding site [chemical binding]; other site
444177003901	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
444177003902	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
444177003903	dimer interface [polypeptide binding]; other site
444177003904	active site
444177003905	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
444177003906	dimer interface [polypeptide binding]; other site
444177003907	active site
444177003908	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
444177003909	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
444177003910	nucleotide binding site [chemical binding]; other site
444177003911	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
444177003912	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
444177003913	Walker A/P-loop; other site
444177003914	ATP binding site [chemical binding]; other site
444177003915	Q-loop/lid; other site
444177003916	ABC transporter signature motif; other site
444177003917	Walker B; other site
444177003918	D-loop; other site
444177003919	H-loop/switch region; other site
444177003920	TOBE domain; Region: TOBE; pfam03459
444177003921	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
444177003922	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
444177003923	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
444177003924	Domain of unknown function DUF; Region: DUF204; pfam02659
444177003925	heme uptake protein IsdC; Region: IsdC; TIGR03656
444177003926	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
444177003927	heme-binding site [chemical binding]; other site
444177003928	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
444177003929	heme-binding site [chemical binding]; other site
444177003930	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
444177003931	heme-binding site [chemical binding]; other site
444177003932	S-layer homology domain; Region: SLH; pfam00395
444177003933	S-layer homology domain; Region: SLH; pfam00395
444177003934	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
444177003935	heme-binding site [chemical binding]; other site
444177003936	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
444177003937	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177003938	intersubunit interface [polypeptide binding]; other site
444177003939	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
444177003940	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177003941	ABC-ATPase subunit  interface; other site
444177003942	dimer interface [polypeptide binding]; other site
444177003943	putative PBP binding regions; other site
444177003944	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
444177003945	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
444177003946	Walker A/P-loop; other site
444177003947	ATP binding site [chemical binding]; other site
444177003948	Q-loop/lid; other site
444177003949	ABC transporter signature motif; other site
444177003950	Walker B; other site
444177003951	D-loop; other site
444177003952	H-loop/switch region; other site
444177003953	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
444177003954	active site
444177003955	catalytic site [active]
444177003956	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
444177003957	putative dimer interface [polypeptide binding]; other site
444177003958	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177003959	Uncharacterized conserved protein [Function unknown]; Region: COG2353
444177003960	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
444177003961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177003962	NAD(P) binding site [chemical binding]; other site
444177003963	active site
444177003964	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177003965	AAA domain; Region: AAA_21; pfam13304
444177003966	Walker A/P-loop; other site
444177003967	ATP binding site [chemical binding]; other site
444177003968	ParB family; Region: ParB; pfam08775
444177003969	RloB-like protein; Region: RloB; pfam13707
444177003970	hydroperoxidase II; Provisional; Region: katE; PRK11249
444177003971	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
444177003972	tetramer interface [polypeptide binding]; other site
444177003973	heme binding pocket [chemical binding]; other site
444177003974	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
444177003975	domain interactions; other site
444177003976	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
444177003977	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
444177003978	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
444177003979	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
444177003980	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
444177003981	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
444177003982	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
444177003983	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
444177003984	NAD(P) binding site [chemical binding]; other site
444177003985	catalytic residues [active]
444177003986	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
444177003987	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
444177003988	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
444177003989	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
444177003990	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
444177003991	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
444177003992	G1 box; other site
444177003993	putative GEF interaction site [polypeptide binding]; other site
444177003994	GTP/Mg2+ binding site [chemical binding]; other site
444177003995	Switch I region; other site
444177003996	G2 box; other site
444177003997	G3 box; other site
444177003998	Switch II region; other site
444177003999	G4 box; other site
444177004000	G5 box; other site
444177004001	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
444177004002	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
444177004003	Protein export membrane protein; Region: SecD_SecF; cl14618
444177004004	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
444177004005	putative NAD(P) binding site [chemical binding]; other site
444177004006	active site
444177004007	putative substrate binding site [chemical binding]; other site
444177004008	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
444177004009	Homeodomain-like domain; Region: HTH_23; cl17451
444177004010	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
444177004011	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
444177004012	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
444177004013	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
444177004014	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177004015	FeS/SAM binding site; other site
444177004016	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
444177004017	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
444177004018	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177004019	dimer interface [polypeptide binding]; other site
444177004020	phosphorylation site [posttranslational modification]
444177004021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177004022	ATP binding site [chemical binding]; other site
444177004023	Mg2+ binding site [ion binding]; other site
444177004024	G-X-G motif; other site
444177004025	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177004026	MarR family; Region: MarR; pfam01047
444177004027	ribonuclease Y; Region: RNase_Y; TIGR03319
444177004028	CAAX protease self-immunity; Region: Abi; pfam02517
444177004029	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953
444177004030	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
444177004031	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
444177004032	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
444177004033	Predicted membrane protein [Function unknown]; Region: COG2259
444177004034	Predicted transcriptional regulators [Transcription]; Region: COG1733
444177004035	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
444177004036	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
444177004037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177004038	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
444177004039	putative CheA interaction surface; other site
444177004040	Response regulator receiver domain; Region: Response_reg; pfam00072
444177004041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177004042	active site
444177004043	phosphorylation site [posttranslational modification]
444177004044	intermolecular recognition site; other site
444177004045	dimerization interface [polypeptide binding]; other site
444177004046	exopolyphosphatase; Region: exo_poly_only; TIGR03706
444177004047	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
444177004048	nucleotide binding site [chemical binding]; other site
444177004049	polyphosphate kinase; Provisional; Region: PRK05443
444177004050	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
444177004051	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
444177004052	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
444177004053	putative domain interface [polypeptide binding]; other site
444177004054	putative active site [active]
444177004055	catalytic site [active]
444177004056	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
444177004057	putative active site [active]
444177004058	catalytic site [active]
444177004059	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177004060	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177004061	metal binding site [ion binding]; metal-binding site
444177004062	active site
444177004063	I-site; other site
444177004064	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
444177004065	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
444177004066	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177004067	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
444177004068	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
444177004069	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
444177004070	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
444177004071	tetrameric interface [polypeptide binding]; other site
444177004072	NAD binding site [chemical binding]; other site
444177004073	catalytic residues [active]
444177004074	Citrate transporter; Region: CitMHS; pfam03600
444177004075	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
444177004076	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177004077	NAD(P) binding site [chemical binding]; other site
444177004078	active site
444177004079	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
444177004080	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
444177004081	active site
444177004082	NAD binding site [chemical binding]; other site
444177004083	metal binding site [ion binding]; metal-binding site
444177004084	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
444177004085	short chain dehydrogenase; Provisional; Region: PRK07677
444177004086	NAD(P) binding site [chemical binding]; other site
444177004087	substrate binding site [chemical binding]; other site
444177004088	homotetramer interface [polypeptide binding]; other site
444177004089	active site
444177004090	homodimer interface [polypeptide binding]; other site
444177004091	FOG: CBS domain [General function prediction only]; Region: COG0517
444177004092	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
444177004093	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177004094	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177004095	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
444177004096	dimerization interface [polypeptide binding]; other site
444177004097	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
444177004098	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
444177004099	Walker A/P-loop; other site
444177004100	ATP binding site [chemical binding]; other site
444177004101	Q-loop/lid; other site
444177004102	ABC transporter signature motif; other site
444177004103	Walker B; other site
444177004104	D-loop; other site
444177004105	H-loop/switch region; other site
444177004106	MoxR-like ATPases [General function prediction only]; Region: COG0714
444177004107	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177004108	Walker A motif; other site
444177004109	ATP binding site [chemical binding]; other site
444177004110	Walker B motif; other site
444177004111	arginine finger; other site
444177004112	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
444177004113	Protein of unknown function DUF58; Region: DUF58; pfam01882
444177004114	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
444177004115	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
444177004116	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
444177004117	metal ion-dependent adhesion site (MIDAS); other site
444177004118	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
444177004119	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
444177004120	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
444177004121	metal ion-dependent adhesion site (MIDAS); other site
444177004122	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
444177004123	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
444177004124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177004125	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177004126	putative substrate translocation pore; other site
444177004127	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
444177004128	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
444177004129	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
444177004130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177004131	dimer interface [polypeptide binding]; other site
444177004132	conserved gate region; other site
444177004133	putative PBP binding loops; other site
444177004134	ABC-ATPase subunit interface; other site
444177004135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177004136	dimer interface [polypeptide binding]; other site
444177004137	conserved gate region; other site
444177004138	putative PBP binding loops; other site
444177004139	ABC-ATPase subunit interface; other site
444177004140	TOBE domain; Region: TOBE_2; pfam08402
444177004141	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177004142	Walker A/P-loop; other site
444177004143	ATP binding site [chemical binding]; other site
444177004144	ABC transporter; Region: ABC_tran; pfam00005
444177004145	Q-loop/lid; other site
444177004146	ABC transporter signature motif; other site
444177004147	Walker B; other site
444177004148	D-loop; other site
444177004149	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
444177004150	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177004151	non-specific DNA binding site [nucleotide binding]; other site
444177004152	salt bridge; other site
444177004153	sequence-specific DNA binding site [nucleotide binding]; other site
444177004154	Cupin domain; Region: Cupin_2; pfam07883
444177004155	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
444177004156	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
444177004157	dimer interface [polypeptide binding]; other site
444177004158	decamer (pentamer of dimers) interface [polypeptide binding]; other site
444177004159	catalytic triad [active]
444177004160	peroxidatic and resolving cysteines [active]
444177004161	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
444177004162	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
444177004163	catalytic residues [active]
444177004164	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
444177004165	TrkA-N domain; Region: TrkA_N; pfam02254
444177004166	TrkA-C domain; Region: TrkA_C; pfam02080
444177004167	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177004168	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177004169	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
444177004170	active site pocket [active]
444177004171	oxyanion hole [active]
444177004172	catalytic triad [active]
444177004173	active site nucleophile [active]
444177004174	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
444177004175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177004176	Coenzyme A binding pocket [chemical binding]; other site
444177004177	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
444177004178	putative dimer interface [polypeptide binding]; other site
444177004179	catalytic triad [active]
444177004180	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177004181	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177004182	Coenzyme A binding pocket [chemical binding]; other site
444177004183	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
444177004184	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
444177004185	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
444177004186	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177004187	putative active site [active]
444177004188	heme pocket [chemical binding]; other site
444177004189	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177004190	ATP binding site [chemical binding]; other site
444177004191	Mg2+ binding site [ion binding]; other site
444177004192	G-X-G motif; other site
444177004193	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
444177004194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177004195	active site
444177004196	phosphorylation site [posttranslational modification]
444177004197	intermolecular recognition site; other site
444177004198	dimerization interface [polypeptide binding]; other site
444177004199	Predicted integral membrane protein [Function unknown]; Region: COG0392
444177004200	Uncharacterized conserved protein [Function unknown]; Region: COG2898
444177004201	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
444177004202	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177004203	H+ Antiporter protein; Region: 2A0121; TIGR00900
444177004204	putative substrate translocation pore; other site
444177004205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177004206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
444177004207	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
444177004208	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
444177004209	Protein export membrane protein; Region: SecD_SecF; cl14618
444177004210	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
444177004211	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177004212	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177004213	Catalytic domain of Protein Kinases; Region: PKc; cd00180
444177004214	active site
444177004215	ATP binding site [chemical binding]; other site
444177004216	substrate binding site [chemical binding]; other site
444177004217	activation loop (A-loop); other site
444177004218	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
444177004219	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
444177004220	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
444177004221	Protein of unknown function (DUF1447); Region: DUF1447; pfam07288
444177004222	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177004223	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
444177004224	active site
444177004225	motif I; other site
444177004226	motif II; other site
444177004227	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177004228	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
444177004229	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
444177004230	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
444177004231	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
444177004232	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
444177004233	Walker A/P-loop; other site
444177004234	ATP binding site [chemical binding]; other site
444177004235	Q-loop/lid; other site
444177004236	ABC transporter signature motif; other site
444177004237	Walker B; other site
444177004238	D-loop; other site
444177004239	H-loop/switch region; other site
444177004240	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
444177004241	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177004242	dimer interface [polypeptide binding]; other site
444177004243	conserved gate region; other site
444177004244	putative PBP binding loops; other site
444177004245	ABC-ATPase subunit interface; other site
444177004246	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
444177004247	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177004248	dimer interface [polypeptide binding]; other site
444177004249	conserved gate region; other site
444177004250	putative PBP binding loops; other site
444177004251	ABC-ATPase subunit interface; other site
444177004252	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
444177004253	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
444177004254	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177004255	catalytic residue [active]
444177004256	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
444177004257	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177004258	motif II; other site
444177004259	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
444177004260	active site
444177004261	catalytic residues [active]
444177004262	metal binding site [ion binding]; metal-binding site
444177004263	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
444177004264	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
444177004265	TPP-binding site [chemical binding]; other site
444177004266	heterodimer interface [polypeptide binding]; other site
444177004267	tetramer interface [polypeptide binding]; other site
444177004268	phosphorylation loop region [posttranslational modification]
444177004269	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
444177004270	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
444177004271	alpha subunit interface [polypeptide binding]; other site
444177004272	TPP binding site [chemical binding]; other site
444177004273	heterodimer interface [polypeptide binding]; other site
444177004274	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
444177004275	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
444177004276	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
444177004277	E3 interaction surface; other site
444177004278	lipoyl attachment site [posttranslational modification]; other site
444177004279	e3 binding domain; Region: E3_binding; pfam02817
444177004280	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
444177004281	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
444177004282	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
444177004283	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
444177004284	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
444177004285	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
444177004286	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
444177004287	putative NAD(P) binding site [chemical binding]; other site
444177004288	putative active site [active]
444177004289	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
444177004290	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
444177004291	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
444177004292	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
444177004293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177004294	active site
444177004295	phosphorylation site [posttranslational modification]
444177004296	intermolecular recognition site; other site
444177004297	dimerization interface [polypeptide binding]; other site
444177004298	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
444177004299	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177004300	ATP binding site [chemical binding]; other site
444177004301	Mg2+ binding site [ion binding]; other site
444177004302	G-X-G motif; other site
444177004303	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
444177004304	LrgB-like family; Region: LrgB; pfam04172
444177004305	tellurite resistance protein TehB; Provisional; Region: PRK12335
444177004306	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
444177004307	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
444177004308	homodimer interface [polypeptide binding]; other site
444177004309	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177004310	catalytic residue [active]
444177004311	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
444177004312	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
444177004313	FMN binding site [chemical binding]; other site
444177004314	substrate binding site [chemical binding]; other site
444177004315	putative catalytic residue [active]
444177004316	Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256
444177004317	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
444177004318	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
444177004319	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
444177004320	active site
444177004321	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
444177004322	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
444177004323	G1 box; other site
444177004324	putative GEF interaction site [polypeptide binding]; other site
444177004325	GTP/Mg2+ binding site [chemical binding]; other site
444177004326	Switch I region; other site
444177004327	G2 box; other site
444177004328	G3 box; other site
444177004329	Switch II region; other site
444177004330	G4 box; other site
444177004331	G5 box; other site
444177004332	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
444177004333	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
444177004334	YlaH-like protein; Region: YlaH; pfam14036
444177004335	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
444177004336	NMT1-like family; Region: NMT1_2; pfam13379
444177004337	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
444177004338	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
444177004339	Walker A/P-loop; other site
444177004340	ATP binding site [chemical binding]; other site
444177004341	Q-loop/lid; other site
444177004342	ABC transporter signature motif; other site
444177004343	Walker B; other site
444177004344	D-loop; other site
444177004345	H-loop/switch region; other site
444177004346	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
444177004347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177004348	dimer interface [polypeptide binding]; other site
444177004349	conserved gate region; other site
444177004350	putative PBP binding loops; other site
444177004351	ABC-ATPase subunit interface; other site
444177004352	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
444177004353	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
444177004354	hypothetical protein; Provisional; Region: PRK13666
444177004355	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
444177004356	pyruvate carboxylase; Reviewed; Region: PRK12999
444177004357	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
444177004358	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
444177004359	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
444177004360	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
444177004361	active site
444177004362	catalytic residues [active]
444177004363	metal binding site [ion binding]; metal-binding site
444177004364	homodimer binding site [polypeptide binding]; other site
444177004365	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
444177004366	carboxyltransferase (CT) interaction site; other site
444177004367	biotinylation site [posttranslational modification]; other site
444177004368	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
444177004369	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
444177004370	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
444177004371	UbiA prenyltransferase family; Region: UbiA; pfam01040
444177004372	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
444177004373	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
444177004374	D-pathway; other site
444177004375	Putative ubiquinol binding site [chemical binding]; other site
444177004376	Low-spin heme (heme b) binding site [chemical binding]; other site
444177004377	Putative water exit pathway; other site
444177004378	Binuclear center (heme o3/CuB) [ion binding]; other site
444177004379	K-pathway; other site
444177004380	Putative proton exit pathway; other site
444177004381	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
444177004382	Subunit I/III interface [polypeptide binding]; other site
444177004383	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
444177004384	Protein of unknown function (DUF420); Region: DUF420; pfam04238
444177004385	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
444177004386	YugN-like family; Region: YugN; pfam08868
444177004387	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
444177004388	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
444177004389	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
444177004390	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
444177004391	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
444177004392	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
444177004393	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
444177004394	CoenzymeA binding site [chemical binding]; other site
444177004395	subunit interaction site [polypeptide binding]; other site
444177004396	PHB binding site; other site
444177004397	Protein of unknown function (DUF964); Region: DUF964; pfam06133
444177004398	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
444177004399	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
444177004400	putative active site [active]
444177004401	catalytic site [active]
444177004402	putative metal binding site [ion binding]; other site
444177004403	hypothetical protein; Provisional; Region: PRK02886
444177004404	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
444177004405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177004406	S-adenosylmethionine binding site [chemical binding]; other site
444177004407	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
444177004408	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
444177004409	active site
444177004410	(T/H)XGH motif; other site
444177004411	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
444177004412	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
444177004413	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
444177004414	protein binding site [polypeptide binding]; other site
444177004415	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
444177004416	hypothetical protein; Provisional; Region: PRK13670
444177004417	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
444177004418	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
444177004419	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
444177004420	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
444177004421	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
444177004422	substrate binding site [chemical binding]; other site
444177004423	oxyanion hole (OAH) forming residues; other site
444177004424	trimer interface [polypeptide binding]; other site
444177004425	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
444177004426	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
444177004427	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
444177004428	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
444177004429	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
444177004430	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
444177004431	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
444177004432	cell division protein MraZ; Reviewed; Region: PRK00326
444177004433	MraZ protein; Region: MraZ; pfam02381
444177004434	MraZ protein; Region: MraZ; pfam02381
444177004435	MraW methylase family; Region: Methyltransf_5; pfam01795
444177004436	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
444177004437	Cell division protein FtsL; Region: FtsL; cl11433
444177004438	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
444177004439	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
444177004440	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
444177004441	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
444177004442	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
444177004443	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
444177004444	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
444177004445	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
444177004446	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
444177004447	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
444177004448	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
444177004449	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
444177004450	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
444177004451	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
444177004452	Cell division protein FtsQ; Region: FtsQ; pfam03799
444177004453	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
444177004454	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
444177004455	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
444177004456	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
444177004457	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
444177004458	nucleotide binding site [chemical binding]; other site
444177004459	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
444177004460	Cell division protein FtsA; Region: FtsA; pfam14450
444177004461	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
444177004462	cell division protein FtsZ; Validated; Region: PRK09330
444177004463	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
444177004464	SulA interaction site; other site
444177004465	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
444177004466	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
444177004467	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177004468	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177004469	DNA binding residues [nucleotide binding]
444177004470	sporulation sigma factor SigG; Reviewed; Region: PRK08215
444177004471	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177004472	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
444177004473	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177004474	DNA binding residues [nucleotide binding]
444177004475	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
444177004476	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
444177004477	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
444177004478	catalytic residue [active]
444177004479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
444177004480	YGGT family; Region: YGGT; pfam02325
444177004481	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
444177004482	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
444177004483	RNA binding surface [nucleotide binding]; other site
444177004484	DivIVA protein; Region: DivIVA; pfam05103
444177004485	DivIVA domain; Region: DivI1A_domain; TIGR03544
444177004486	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
444177004487	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
444177004488	active site
444177004489	HIGH motif; other site
444177004490	nucleotide binding site [chemical binding]; other site
444177004491	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
444177004492	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
444177004493	active site
444177004494	KMSKS motif; other site
444177004495	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
444177004496	tRNA binding surface [nucleotide binding]; other site
444177004497	anticodon binding site; other site
444177004498	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
444177004499	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
444177004500	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177004501	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177004502	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
444177004503	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
444177004504	Na binding site [ion binding]; other site
444177004505	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
444177004506	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
444177004507	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
444177004508	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
444177004509	RNA binding surface [nucleotide binding]; other site
444177004510	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
444177004511	active site
444177004512	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
444177004513	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
444177004514	active site
444177004515	uracil transporter; Provisional; Region: PRK10720
444177004516	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
444177004517	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
444177004518	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
444177004519	dihydroorotase; Validated; Region: pyrC; PRK09357
444177004520	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
444177004521	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
444177004522	active site
444177004523	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
444177004524	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
444177004525	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
444177004526	catalytic site [active]
444177004527	subunit interface [polypeptide binding]; other site
444177004528	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
444177004529	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
444177004530	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
444177004531	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
444177004532	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
444177004533	ATP-grasp domain; Region: ATP-grasp_4; cl17255
444177004534	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
444177004535	IMP binding site; other site
444177004536	dimer interface [polypeptide binding]; other site
444177004537	interdomain contacts; other site
444177004538	partial ornithine binding site; other site
444177004539	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
444177004540	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
444177004541	FAD binding pocket [chemical binding]; other site
444177004542	FAD binding motif [chemical binding]; other site
444177004543	phosphate binding motif [ion binding]; other site
444177004544	beta-alpha-beta structure motif; other site
444177004545	NAD binding pocket [chemical binding]; other site
444177004546	Iron coordination center [ion binding]; other site
444177004547	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
444177004548	active site
444177004549	dimer interface [polypeptide binding]; other site
444177004550	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
444177004551	active site
444177004552	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177004553	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
444177004554	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177004555	Walker A/P-loop; other site
444177004556	ATP binding site [chemical binding]; other site
444177004557	Q-loop/lid; other site
444177004558	ABC transporter signature motif; other site
444177004559	Walker B; other site
444177004560	D-loop; other site
444177004561	H-loop/switch region; other site
444177004562	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
444177004563	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
444177004564	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177004565	Walker A/P-loop; other site
444177004566	ATP binding site [chemical binding]; other site
444177004567	Q-loop/lid; other site
444177004568	ABC transporter signature motif; other site
444177004569	Walker B; other site
444177004570	D-loop; other site
444177004571	H-loop/switch region; other site
444177004572	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
444177004573	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177004574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177004575	dimer interface [polypeptide binding]; other site
444177004576	conserved gate region; other site
444177004577	putative PBP binding loops; other site
444177004578	ABC-ATPase subunit interface; other site
444177004579	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
444177004580	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177004581	dimer interface [polypeptide binding]; other site
444177004582	conserved gate region; other site
444177004583	putative PBP binding loops; other site
444177004584	ABC-ATPase subunit interface; other site
444177004585	The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
444177004586	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
444177004587	peptide binding site [polypeptide binding]; other site
444177004588	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
444177004589	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177004590	Walker A/P-loop; other site
444177004591	ATP binding site [chemical binding]; other site
444177004592	Q-loop/lid; other site
444177004593	ABC transporter signature motif; other site
444177004594	Walker B; other site
444177004595	D-loop; other site
444177004596	H-loop/switch region; other site
444177004597	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
444177004598	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
444177004599	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177004600	Walker A/P-loop; other site
444177004601	ATP binding site [chemical binding]; other site
444177004602	Q-loop/lid; other site
444177004603	ABC transporter signature motif; other site
444177004604	Walker B; other site
444177004605	D-loop; other site
444177004606	H-loop/switch region; other site
444177004607	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
444177004608	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
444177004609	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
444177004610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177004611	dimer interface [polypeptide binding]; other site
444177004612	conserved gate region; other site
444177004613	putative PBP binding loops; other site
444177004614	ABC-ATPase subunit interface; other site
444177004615	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177004616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177004617	dimer interface [polypeptide binding]; other site
444177004618	conserved gate region; other site
444177004619	putative PBP binding loops; other site
444177004620	ABC-ATPase subunit interface; other site
444177004621	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
444177004622	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
444177004623	peptide binding site [polypeptide binding]; other site
444177004624	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177004625	dimerization interface [polypeptide binding]; other site
444177004626	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177004627	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177004628	dimer interface [polypeptide binding]; other site
444177004629	putative CheW interface [polypeptide binding]; other site
444177004630	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
444177004631	Domain of unknown function (DUF814); Region: DUF814; pfam05670
444177004632	hypothetical protein; Provisional; Region: PRK11820
444177004633	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
444177004634	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
444177004635	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
444177004636	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
444177004637	catalytic site [active]
444177004638	G-X2-G-X-G-K; other site
444177004639	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
444177004640	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
444177004641	Flavoprotein; Region: Flavoprotein; pfam02441
444177004642	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
444177004643	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
444177004644	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
444177004645	ATP binding site [chemical binding]; other site
444177004646	putative Mg++ binding site [ion binding]; other site
444177004647	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177004648	ATP-binding site [chemical binding]; other site
444177004649	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
444177004650	active site
444177004651	catalytic residues [active]
444177004652	metal binding site [ion binding]; metal-binding site
444177004653	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
444177004654	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
444177004655	putative active site [active]
444177004656	substrate binding site [chemical binding]; other site
444177004657	putative cosubstrate binding site; other site
444177004658	catalytic site [active]
444177004659	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
444177004660	substrate binding site [chemical binding]; other site
444177004661	16S rRNA methyltransferase B; Provisional; Region: PRK14902
444177004662	NusB family; Region: NusB; pfam01029
444177004663	putative RNA binding site [nucleotide binding]; other site
444177004664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177004665	S-adenosylmethionine binding site [chemical binding]; other site
444177004666	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
444177004667	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177004668	FeS/SAM binding site; other site
444177004669	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
444177004670	active site
444177004671	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
444177004672	Catalytic domain of Protein Kinases; Region: PKc; cd00180
444177004673	active site
444177004674	ATP binding site [chemical binding]; other site
444177004675	substrate binding site [chemical binding]; other site
444177004676	activation loop (A-loop); other site
444177004677	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
444177004678	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
444177004679	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
444177004680	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
444177004681	GTPase RsgA; Reviewed; Region: PRK00098
444177004682	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
444177004683	RNA binding site [nucleotide binding]; other site
444177004684	homodimer interface [polypeptide binding]; other site
444177004685	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
444177004686	GTPase/Zn-binding domain interface [polypeptide binding]; other site
444177004687	GTP/Mg2+ binding site [chemical binding]; other site
444177004688	G4 box; other site
444177004689	G5 box; other site
444177004690	G1 box; other site
444177004691	Switch I region; other site
444177004692	G2 box; other site
444177004693	G3 box; other site
444177004694	Switch II region; other site
444177004695	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
444177004696	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
444177004697	substrate binding site [chemical binding]; other site
444177004698	hexamer interface [polypeptide binding]; other site
444177004699	metal binding site [ion binding]; metal-binding site
444177004700	Thiamine pyrophosphokinase; Region: TPK; cd07995
444177004701	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
444177004702	active site
444177004703	dimerization interface [polypeptide binding]; other site
444177004704	thiamine binding site [chemical binding]; other site
444177004705	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
444177004706	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
444177004707	Transcriptional regulator [Transcription]; Region: IclR; COG1414
444177004708	Bacterial transcriptional regulator; Region: IclR; pfam01614
444177004709	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
444177004710	Amidinotransferase; Region: Amidinotransf; pfam02274
444177004711	S-methylmethionine transporter; Provisional; Region: PRK11387
444177004712	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
444177004713	putative metal binding site [ion binding]; other site
444177004714	putative dimer interface [polypeptide binding]; other site
444177004715	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
444177004716	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
444177004717	DAK2 domain; Region: Dak2; pfam02734
444177004718	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
444177004719	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
444177004720	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
444177004721	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
444177004722	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
444177004723	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177004724	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177004725	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
444177004726	dimerization interface [polypeptide binding]; other site
444177004727	Predicted membrane protein [Function unknown]; Region: COG1288
444177004728	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
444177004729	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
444177004730	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
444177004731	metal binding site [ion binding]; metal-binding site
444177004732	dimer interface [polypeptide binding]; other site
444177004733	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
444177004734	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
444177004735	active site
444177004736	Y-family of DNA polymerases; Region: PolY; cl12025
444177004737	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
444177004738	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
444177004739	generic binding surface II; other site
444177004740	ssDNA binding site; other site
444177004741	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
444177004742	ATP binding site [chemical binding]; other site
444177004743	putative Mg++ binding site [ion binding]; other site
444177004744	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177004745	nucleotide binding region [chemical binding]; other site
444177004746	ATP-binding site [chemical binding]; other site
444177004747	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
444177004748	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
444177004749	active site 2 [active]
444177004750	active site 1 [active]
444177004751	putative phosphate acyltransferase; Provisional; Region: PRK05331
444177004752	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
444177004753	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
444177004754	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
444177004755	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
444177004756	NAD(P) binding site [chemical binding]; other site
444177004757	homotetramer interface [polypeptide binding]; other site
444177004758	homodimer interface [polypeptide binding]; other site
444177004759	active site
444177004760	acyl carrier protein; Provisional; Region: acpP; PRK00982
444177004761	ribonuclease III; Reviewed; Region: rnc; PRK00102
444177004762	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
444177004763	dimerization interface [polypeptide binding]; other site
444177004764	active site
444177004765	metal binding site [ion binding]; metal-binding site
444177004766	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
444177004767	dsRNA binding site [nucleotide binding]; other site
444177004768	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
444177004769	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
444177004770	Walker A/P-loop; other site
444177004771	ATP binding site [chemical binding]; other site
444177004772	Q-loop/lid; other site
444177004773	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
444177004774	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
444177004775	ABC transporter signature motif; other site
444177004776	Walker B; other site
444177004777	D-loop; other site
444177004778	H-loop/switch region; other site
444177004779	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
444177004780	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
444177004781	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
444177004782	P loop; other site
444177004783	GTP binding site [chemical binding]; other site
444177004784	putative DNA-binding protein; Validated; Region: PRK00118
444177004785	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
444177004786	signal recognition particle protein; Provisional; Region: PRK10867
444177004787	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
444177004788	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
444177004789	P loop; other site
444177004790	GTP binding site [chemical binding]; other site
444177004791	Signal peptide binding domain; Region: SRP_SPB; pfam02978
444177004792	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
444177004793	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
444177004794	KH domain; Region: KH_4; pfam13083
444177004795	G-X-X-G motif; other site
444177004796	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
444177004797	RimM N-terminal domain; Region: RimM; pfam01782
444177004798	PRC-barrel domain; Region: PRC; pfam05239
444177004799	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
444177004800	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
444177004801	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
444177004802	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
444177004803	Catalytic site [active]
444177004804	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
444177004805	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
444177004806	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
444177004807	GTP/Mg2+ binding site [chemical binding]; other site
444177004808	G4 box; other site
444177004809	G5 box; other site
444177004810	G1 box; other site
444177004811	Switch I region; other site
444177004812	G2 box; other site
444177004813	G3 box; other site
444177004814	Switch II region; other site
444177004815	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
444177004816	RNA/DNA hybrid binding site [nucleotide binding]; other site
444177004817	active site
444177004818	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
444177004819	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
444177004820	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
444177004821	CoA-ligase; Region: Ligase_CoA; pfam00549
444177004822	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
444177004823	CoA binding domain; Region: CoA_binding; pfam02629
444177004824	CoA-ligase; Region: Ligase_CoA; pfam00549
444177004825	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
444177004826	DNA protecting protein DprA; Region: dprA; TIGR00732
444177004827	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
444177004828	Glucose inhibited division protein A; Region: GIDA; pfam01134
444177004829	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177004830	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
444177004831	active site
444177004832	DNA binding site [nucleotide binding]
444177004833	Int/Topo IB signature motif; other site
444177004834	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
444177004835	active site
444177004836	HslU subunit interaction site [polypeptide binding]; other site
444177004837	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
444177004838	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177004839	Walker A motif; other site
444177004840	ATP binding site [chemical binding]; other site
444177004841	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
444177004842	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
444177004843	transcriptional repressor CodY; Validated; Region: PRK04158
444177004844	CodY GAF-like domain; Region: CodY; pfam06018
444177004845	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
444177004846	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
444177004847	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
444177004848	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
444177004849	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
444177004850	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
444177004851	flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728
444177004852	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
444177004853	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
444177004854	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
444177004855	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
444177004856	MgtE intracellular N domain; Region: MgtE_N; smart00924
444177004857	FliG C-terminal domain; Region: FliG_C; pfam01706
444177004858	Flagellar assembly protein FliH; Region: FliH; pfam02108
444177004859	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721
444177004860	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
444177004861	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
444177004862	Walker A motif/ATP binding site; other site
444177004863	Walker B motif; other site
444177004864	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720
444177004865	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
444177004866	Uncharacterized conserved protein [Function unknown]; Region: COG3334
444177004867	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
444177004868	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
444177004869	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
444177004870	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
444177004871	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
444177004872	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
444177004873	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
444177004874	Flagellar protein (FlbD); Region: FlbD; pfam06289
444177004875	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
444177004876	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
444177004877	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
444177004878	flagellar motor switch protein; Validated; Region: PRK08119
444177004879	CheC-like family; Region: CheC; pfam04509
444177004880	CheC-like family; Region: CheC; pfam04509
444177004881	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
444177004882	Response regulator receiver domain; Region: Response_reg; pfam00072
444177004883	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177004884	active site
444177004885	phosphorylation site [posttranslational modification]
444177004886	intermolecular recognition site; other site
444177004887	dimerization interface [polypeptide binding]; other site
444177004888	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
444177004889	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
444177004890	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
444177004891	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
444177004892	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
444177004893	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
444177004894	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
444177004895	FHIPEP family; Region: FHIPEP; pfam00771
444177004896	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
444177004897	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
444177004898	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
444177004899	P-loop; other site
444177004900	septum site-determining protein MinD; Region: minD_bact; TIGR01968
444177004901	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
444177004902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177004903	active site
444177004904	phosphorylation site [posttranslational modification]
444177004905	intermolecular recognition site; other site
444177004906	dimerization interface [polypeptide binding]; other site
444177004907	CheB methylesterase; Region: CheB_methylest; pfam01339
444177004908	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
444177004909	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
444177004910	putative binding surface; other site
444177004911	active site
444177004912	P2 response regulator binding domain; Region: P2; pfam07194
444177004913	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
444177004914	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177004915	ATP binding site [chemical binding]; other site
444177004916	Mg2+ binding site [ion binding]; other site
444177004917	G-X-G motif; other site
444177004918	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
444177004919	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
444177004920	putative CheA interaction surface; other site
444177004921	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
444177004922	CheC-like family; Region: CheC; pfam04509
444177004923	CheC-like family; Region: CheC; pfam04509
444177004924	Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871
444177004925	RNA polymerase sigma factor SigD; Validated; Region: PRK07670
444177004926	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177004927	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
444177004928	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177004929	DNA binding residues [nucleotide binding]
444177004930	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
444177004931	rRNA interaction site [nucleotide binding]; other site
444177004932	S8 interaction site; other site
444177004933	putative laminin-1 binding site; other site
444177004934	elongation factor Ts; Provisional; Region: tsf; PRK09377
444177004935	UBA/TS-N domain; Region: UBA; pfam00627
444177004936	Elongation factor TS; Region: EF_TS; pfam00889
444177004937	Elongation factor TS; Region: EF_TS; pfam00889
444177004938	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
444177004939	putative nucleotide binding site [chemical binding]; other site
444177004940	uridine monophosphate binding site [chemical binding]; other site
444177004941	homohexameric interface [polypeptide binding]; other site
444177004942	Ribosome recycling factor [Translation, ribosomal structure and biogenesis]; Region: Frr; COG0233
444177004943	ribosome recycling factor; Reviewed; Region: frr; PRK00083
444177004944	hinge region; other site
444177004945	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
444177004946	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
444177004947	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
444177004948	catalytic residue [active]
444177004949	putative FPP diphosphate  binding site; other site
444177004950	putative FPP binding hydrophobic cleft; other site
444177004951	dimer interface [polypeptide binding]; other site
444177004952	putative IPP diphosphate binding site; other site
444177004953	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
444177004954	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
444177004955	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
444177004956	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
444177004957	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
444177004958	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
444177004959	RIP metalloprotease RseP; Region: TIGR00054
444177004960	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
444177004961	active site
444177004962	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
444177004963	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
444177004964	protein binding site [polypeptide binding]; other site
444177004965	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
444177004966	putative substrate binding region [chemical binding]; other site
444177004967	prolyl-tRNA synthetase; Provisional; Region: PRK09194
444177004968	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
444177004969	dimer interface [polypeptide binding]; other site
444177004970	motif 1; other site
444177004971	active site
444177004972	motif 2; other site
444177004973	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
444177004974	putative deacylase active site [active]
444177004975	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
444177004976	active site
444177004977	motif 3; other site
444177004978	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
444177004979	anticodon binding site; other site
444177004980	DNA polymerase III PolC; Validated; Region: polC; PRK00448
444177004981	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
444177004982	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
444177004983	generic binding surface I; other site
444177004984	generic binding surface II; other site
444177004985	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
444177004986	active site
444177004987	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
444177004988	active site
444177004989	catalytic site [active]
444177004990	substrate binding site [chemical binding]; other site
444177004991	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
444177004992	ribosome maturation protein RimP; Reviewed; Region: PRK00092
444177004993	Sm and related proteins; Region: Sm_like; cl00259
444177004994	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
444177004995	putative oligomer interface [polypeptide binding]; other site
444177004996	putative RNA binding site [nucleotide binding]; other site
444177004997	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
444177004998	NusA N-terminal domain; Region: NusA_N; pfam08529
444177004999	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
444177005000	RNA binding site [nucleotide binding]; other site
444177005001	homodimer interface [polypeptide binding]; other site
444177005002	NusA-like KH domain; Region: KH_5; pfam13184
444177005003	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
444177005004	G-X-X-G motif; other site
444177005005	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
444177005006	putative RNA binding cleft [nucleotide binding]; other site
444177005007	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
444177005008	translation initiation factor IF-2; Validated; Region: infB; PRK05306
444177005009	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
444177005010	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
444177005011	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
444177005012	G1 box; other site
444177005013	putative GEF interaction site [polypeptide binding]; other site
444177005014	GTP/Mg2+ binding site [chemical binding]; other site
444177005015	Switch I region; other site
444177005016	G2 box; other site
444177005017	G3 box; other site
444177005018	Switch II region; other site
444177005019	G4 box; other site
444177005020	G5 box; other site
444177005021	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
444177005022	Translation-initiation factor 2; Region: IF-2; pfam11987
444177005023	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
444177005024	Protein of unknown function (DUF503); Region: DUF503; pfam04456
444177005025	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
444177005026	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
444177005027	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
444177005028	RNA binding site [nucleotide binding]; other site
444177005029	active site
444177005030	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
444177005031	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
444177005032	active site
444177005033	Riboflavin kinase; Region: Flavokinase; pfam01687
444177005034	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
444177005035	16S/18S rRNA binding site [nucleotide binding]; other site
444177005036	S13e-L30e interaction site [polypeptide binding]; other site
444177005037	25S rRNA binding site [nucleotide binding]; other site
444177005038	Predicted membrane protein [Function unknown]; Region: COG2259
444177005039	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
444177005040	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
444177005041	RNase E interface [polypeptide binding]; other site
444177005042	trimer interface [polypeptide binding]; other site
444177005043	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
444177005044	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
444177005045	RNase E interface [polypeptide binding]; other site
444177005046	trimer interface [polypeptide binding]; other site
444177005047	active site
444177005048	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
444177005049	putative nucleic acid binding region [nucleotide binding]; other site
444177005050	G-X-X-G motif; other site
444177005051	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
444177005052	RNA binding site [nucleotide binding]; other site
444177005053	domain interface; other site
444177005054	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
444177005055	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
444177005056	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
444177005057	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
444177005058	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
444177005059	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
444177005060	NAD binding site [chemical binding]; other site
444177005061	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
444177005062	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
444177005063	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
444177005064	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
444177005065	dihydrodipicolinate synthase; Region: dapA; TIGR00674
444177005066	dimer interface [polypeptide binding]; other site
444177005067	active site
444177005068	catalytic residue [active]
444177005069	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
444177005070	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177005071	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
444177005072	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
444177005073	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
444177005074	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
444177005075	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
444177005076	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
444177005077	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177005078	DNA-binding site [nucleotide binding]; DNA binding site
444177005079	UTRA domain; Region: UTRA; pfam07702
444177005080	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
444177005081	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
444177005082	ligand binding site [chemical binding]; other site
444177005083	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
444177005084	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177005085	Walker A/P-loop; other site
444177005086	ATP binding site [chemical binding]; other site
444177005087	Q-loop/lid; other site
444177005088	ABC transporter signature motif; other site
444177005089	Walker B; other site
444177005090	D-loop; other site
444177005091	H-loop/switch region; other site
444177005092	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
444177005093	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
444177005094	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
444177005095	TM-ABC transporter signature motif; other site
444177005096	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
444177005097	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
444177005098	TM-ABC transporter signature motif; other site
444177005099	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
444177005100	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
444177005101	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
444177005102	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
444177005103	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
444177005104	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
444177005105	classical (c) SDRs; Region: SDR_c; cd05233
444177005106	NAD(P) binding site [chemical binding]; other site
444177005107	active site
444177005108	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
444177005109	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
444177005110	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
444177005111	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
444177005112	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177005113	non-specific DNA binding site [nucleotide binding]; other site
444177005114	salt bridge; other site
444177005115	sequence-specific DNA binding site [nucleotide binding]; other site
444177005116	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
444177005117	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
444177005118	competence damage-inducible protein A; Provisional; Region: PRK00549
444177005119	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
444177005120	putative MPT binding site; other site
444177005121	Competence-damaged protein; Region: CinA; pfam02464
444177005122	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
444177005123	hexamer interface [polypeptide binding]; other site
444177005124	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
444177005125	Walker A motif; other site
444177005126	ATP binding site [chemical binding]; other site
444177005127	Walker B motif; other site
444177005128	phosphodiesterase; Provisional; Region: PRK12704
444177005129	Uncharacterized conserved protein [Function unknown]; Region: COG3334
444177005130	uncharacterized domain HDIG; Region: HDIG; TIGR00277
444177005131	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
444177005132	O-Antigen ligase; Region: Wzy_C; pfam04932
444177005133	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
444177005134	Chain length determinant protein; Region: Wzz; cl15801
444177005135	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
444177005136	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
444177005137	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
444177005138	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
444177005139	putative ADP-binding pocket [chemical binding]; other site
444177005140	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
444177005141	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
444177005142	putative ADP-binding pocket [chemical binding]; other site
444177005143	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
444177005144	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
444177005145	putative glycosyl transferase; Provisional; Region: PRK10073
444177005146	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
444177005147	active site
444177005148	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
444177005149	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
444177005150	putative active site [active]
444177005151	metal binding site [ion binding]; metal-binding site
444177005152	homodimer binding site [polypeptide binding]; other site
444177005153	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
444177005154	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
444177005155	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
444177005156	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
444177005157	dimer interface [polypeptide binding]; other site
444177005158	PYR/PP interface [polypeptide binding]; other site
444177005159	TPP binding site [chemical binding]; other site
444177005160	substrate binding site [chemical binding]; other site
444177005161	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
444177005162	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
444177005163	TPP-binding site [chemical binding]; other site
444177005164	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
444177005165	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
444177005166	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
444177005167	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
444177005168	Sulfatase; Region: Sulfatase; cl17466
444177005169	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
444177005170	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
444177005171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177005172	dimer interface [polypeptide binding]; other site
444177005173	conserved gate region; other site
444177005174	putative PBP binding loops; other site
444177005175	ABC-ATPase subunit interface; other site
444177005176	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
444177005177	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177005178	Walker A/P-loop; other site
444177005179	ATP binding site [chemical binding]; other site
444177005180	Q-loop/lid; other site
444177005181	ABC transporter signature motif; other site
444177005182	Walker B; other site
444177005183	D-loop; other site
444177005184	H-loop/switch region; other site
444177005185	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
444177005186	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
444177005187	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
444177005188	histidinol-phosphatase; Validated; Region: PRK06740
444177005189	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
444177005190	dimer interface [polypeptide binding]; other site
444177005191	active site
444177005192	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
444177005193	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
444177005194	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
444177005195	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
444177005196	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177005197	FeS/SAM binding site; other site
444177005198	TRAM domain; Region: TRAM; cl01282
444177005199	Predicted membrane protein [Function unknown]; Region: COG4550
444177005200	Outer spore coat protein E (CotE); Region: CotE; pfam10628
444177005201	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
444177005202	MutS domain I; Region: MutS_I; pfam01624
444177005203	MutS domain II; Region: MutS_II; pfam05188
444177005204	MutS domain III; Region: MutS_III; pfam05192
444177005205	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
444177005206	Walker A/P-loop; other site
444177005207	ATP binding site [chemical binding]; other site
444177005208	Q-loop/lid; other site
444177005209	ABC transporter signature motif; other site
444177005210	Walker B; other site
444177005211	D-loop; other site
444177005212	H-loop/switch region; other site
444177005213	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
444177005214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177005215	ATP binding site [chemical binding]; other site
444177005216	Mg2+ binding site [ion binding]; other site
444177005217	G-X-G motif; other site
444177005218	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
444177005219	ATP binding site [chemical binding]; other site
444177005220	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
444177005221	glycerol kinase; Provisional; Region: glpK; PRK00047
444177005222	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
444177005223	N- and C-terminal domain interface [polypeptide binding]; other site
444177005224	active site
444177005225	MgATP binding site [chemical binding]; other site
444177005226	catalytic site [active]
444177005227	metal binding site [ion binding]; metal-binding site
444177005228	glycerol binding site [chemical binding]; other site
444177005229	homotetramer interface [polypeptide binding]; other site
444177005230	homodimer interface [polypeptide binding]; other site
444177005231	FBP binding site [chemical binding]; other site
444177005232	protein IIAGlc interface [polypeptide binding]; other site
444177005233	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
444177005234	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
444177005235	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
444177005236	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
444177005237	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
444177005238	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
444177005239	active site residue [active]
444177005240	EamA-like transporter family; Region: EamA; pfam00892
444177005241	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
444177005242	EamA-like transporter family; Region: EamA; pfam00892
444177005243	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
444177005244	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
444177005245	active site pocket [active]
444177005246	putative dimer interface [polypeptide binding]; other site
444177005247	putative cataytic base [active]
444177005248	Predicted membrane protein [Function unknown]; Region: COG2860
444177005249	UPF0126 domain; Region: UPF0126; pfam03458
444177005250	UPF0126 domain; Region: UPF0126; pfam03458
444177005251	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
444177005252	Aluminium resistance protein; Region: Alum_res; pfam06838
444177005253	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
444177005254	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
444177005255	DNA binding residues [nucleotide binding]
444177005256	putative dimer interface [polypeptide binding]; other site
444177005257	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
444177005258	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
444177005259	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
444177005260	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
444177005261	Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122
444177005262	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177005263	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
444177005264	siderophore binding site; other site
444177005265	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
444177005266	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177005267	dimer interface [polypeptide binding]; other site
444177005268	ABC-ATPase subunit  interface; other site
444177005269	putative PBP binding regions; other site
444177005270	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
444177005271	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
444177005272	Walker A/P-loop; other site
444177005273	ATP binding site [chemical binding]; other site
444177005274	Q-loop/lid; other site
444177005275	ABC transporter signature motif; other site
444177005276	Walker B; other site
444177005277	D-loop; other site
444177005278	H-loop/switch region; other site
444177005279	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
444177005280	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
444177005281	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
444177005282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
444177005283	Nucleoside recognition; Region: Gate; pfam07670
444177005284	CAAX protease self-immunity; Region: Abi; pfam02517
444177005285	Acyltransferase family; Region: Acyl_transf_3; pfam01757
444177005286	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
444177005287	Bacteriophage holin; Region: Phage_holin_1; pfam04531
444177005288	basic region leucin zipper; Region: BRLZ; smart00338
444177005289	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
444177005290	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
444177005291	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
444177005292	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
444177005293	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
444177005294	catalytic triad [active]
444177005295	LexA repressor; Validated; Region: PRK00215
444177005296	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177005297	putative DNA binding site [nucleotide binding]; other site
444177005298	putative Zn2+ binding site [ion binding]; other site
444177005299	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
444177005300	Catalytic site [active]
444177005301	cell division suppressor protein YneA; Provisional; Region: PRK14125
444177005302	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
444177005303	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
444177005304	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
444177005305	catalytic residues [active]
444177005306	catalytic nucleophile [active]
444177005307	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
444177005308	active site
444177005309	catalytic residues [active]
444177005310	metal binding site [ion binding]; metal-binding site
444177005311	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177005312	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177005313	Coenzyme A binding pocket [chemical binding]; other site
444177005314	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
444177005315	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
444177005316	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
444177005317	TPP-binding site [chemical binding]; other site
444177005318	dimer interface [polypeptide binding]; other site
444177005319	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
444177005320	PYR/PP interface [polypeptide binding]; other site
444177005321	dimer interface [polypeptide binding]; other site
444177005322	TPP binding site [chemical binding]; other site
444177005323	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
444177005324	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177005325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177005326	active site
444177005327	phosphorylation site [posttranslational modification]
444177005328	intermolecular recognition site; other site
444177005329	dimerization interface [polypeptide binding]; other site
444177005330	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
444177005331	DNA binding residues [nucleotide binding]
444177005332	dimerization interface [polypeptide binding]; other site
444177005333	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
444177005334	Histidine kinase; Region: HisKA_3; pfam07730
444177005335	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177005336	ATP binding site [chemical binding]; other site
444177005337	Mg2+ binding site [ion binding]; other site
444177005338	G-X-G motif; other site
444177005339	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
444177005340	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
444177005341	Protein of unknown function (DUF2522); Region: DUF2522; pfam10747
444177005342	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
444177005343	S-ribosylhomocysteinase; Provisional; Region: PRK02260
444177005344	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
444177005345	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
444177005346	putative acyltransferase; Provisional; Region: PRK05790
444177005347	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
444177005348	dimer interface [polypeptide binding]; other site
444177005349	active site
444177005350	Protein of unknown function (DUF3886); Region: DUF3886; pfam13025
444177005351	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
444177005352	Predicted integral membrane protein [Function unknown]; Region: COG5652
444177005353	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
444177005354	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
444177005355	active site
444177005356	catalytic tetrad [active]
444177005357	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
444177005358	dimer interface [polypeptide binding]; other site
444177005359	ADP-ribose binding site [chemical binding]; other site
444177005360	active site
444177005361	nudix motif; other site
444177005362	metal binding site [ion binding]; metal-binding site
444177005363	ferric uptake regulator; Provisional; Region: fur; PRK09462
444177005364	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
444177005365	metal binding site 2 [ion binding]; metal-binding site
444177005366	putative DNA binding helix; other site
444177005367	metal binding site 1 [ion binding]; metal-binding site
444177005368	dimer interface [polypeptide binding]; other site
444177005369	structural Zn2+ binding site [ion binding]; other site
444177005370	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
444177005371	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
444177005372	active site
444177005373	Int/Topo IB signature motif; other site
444177005374	phosphopentomutase; Provisional; Region: PRK05362
444177005375	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
444177005376	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
444177005377	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
444177005378	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
444177005379	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
444177005380	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cd06844
444177005381	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
444177005382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177005383	ATP binding site [chemical binding]; other site
444177005384	Mg2+ binding site [ion binding]; other site
444177005385	G-X-G motif; other site
444177005386	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177005387	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
444177005388	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177005389	DNA binding residues [nucleotide binding]
444177005390	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177005391	diaminopimelate decarboxylase; Region: lysA; TIGR01048
444177005392	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
444177005393	active site
444177005394	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
444177005395	substrate binding site [chemical binding]; other site
444177005396	catalytic residues [active]
444177005397	dimer interface [polypeptide binding]; other site
444177005398	Domain of unknown function (DUF309); Region: DUF309; pfam03745
444177005399	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
444177005400	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
444177005401	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
444177005402	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
444177005403	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
444177005404	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
444177005405	RNA binding surface [nucleotide binding]; other site
444177005406	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
444177005407	active site
444177005408	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
444177005409	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
444177005410	catalytic residues [active]
444177005411	ResB-like family; Region: ResB; pfam05140
444177005412	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
444177005413	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
444177005414	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
444177005415	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177005416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177005417	active site
444177005418	phosphorylation site [posttranslational modification]
444177005419	intermolecular recognition site; other site
444177005420	dimerization interface [polypeptide binding]; other site
444177005421	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177005422	DNA binding site [nucleotide binding]
444177005423	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
444177005424	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177005425	dimerization interface [polypeptide binding]; other site
444177005426	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177005427	dimer interface [polypeptide binding]; other site
444177005428	phosphorylation site [posttranslational modification]
444177005429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177005430	ATP binding site [chemical binding]; other site
444177005431	Mg2+ binding site [ion binding]; other site
444177005432	G-X-G motif; other site
444177005433	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
444177005434	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177005435	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177005436	DNA binding residues [nucleotide binding]
444177005437	Predicted membrane protein [Function unknown]; Region: COG3601
444177005438	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
444177005439	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
444177005440	Na2 binding site [ion binding]; other site
444177005441	putative substrate binding site 1 [chemical binding]; other site
444177005442	Na binding site 1 [ion binding]; other site
444177005443	putative substrate binding site 2 [chemical binding]; other site
444177005444	glutamine synthetase, type I; Region: GlnA; TIGR00653
444177005445	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
444177005446	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
444177005447	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177005448	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177005449	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177005450	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
444177005451	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869
444177005452	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177005453	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177005454	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
444177005455	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177005456	Predicted membrane protein [Function unknown]; Region: COG2311
444177005457	Protein of unknown function (DUF418); Region: DUF418; pfam04235
444177005458	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
444177005459	putative deacylase active site [active]
444177005460	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
444177005461	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
444177005462	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
444177005463	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
444177005464	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
444177005465	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177005466	dimer interface [polypeptide binding]; other site
444177005467	conserved gate region; other site
444177005468	putative PBP binding loops; other site
444177005469	ABC-ATPase subunit interface; other site
444177005470	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
444177005471	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
444177005472	Walker A/P-loop; other site
444177005473	ATP binding site [chemical binding]; other site
444177005474	Q-loop/lid; other site
444177005475	ABC transporter signature motif; other site
444177005476	Walker B; other site
444177005477	D-loop; other site
444177005478	H-loop/switch region; other site
444177005479	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
444177005480	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
444177005481	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177005482	DNA-binding site [nucleotide binding]; DNA binding site
444177005483	TrkA-C domain; Region: TrkA_C; pfam02080
444177005484	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
444177005485	dimerization interface [polypeptide binding]; other site
444177005486	active site
444177005487	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
444177005488	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
444177005489	catalytic motif [active]
444177005490	Zn binding site [ion binding]; other site
444177005491	RibD C-terminal domain; Region: RibD_C; cl17279
444177005492	FAD binding domain; Region: FAD_binding_3; pfam01494
444177005493	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
444177005494	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
444177005495	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
444177005496	hydroxyglutarate oxidase; Provisional; Region: PRK11728
444177005497	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
444177005498	guanine deaminase; Region: guan_deamin; TIGR02967
444177005499	active site
444177005500	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177005501	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177005502	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
444177005503	dimerization interface [polypeptide binding]; other site
444177005504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177005505	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
444177005506	putative substrate translocation pore; other site
444177005507	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
444177005508	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177005509	S-adenosylmethionine binding site [chemical binding]; other site
444177005510	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
444177005511	putative active site [active]
444177005512	nucleotide binding site [chemical binding]; other site
444177005513	nudix motif; other site
444177005514	putative metal binding site [ion binding]; other site
444177005515	Uncharacterized conserved protein [Function unknown]; Region: COG1683
444177005516	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
444177005517	Response regulator receiver domain; Region: Response_reg; pfam00072
444177005518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177005519	active site
444177005520	phosphorylation site [posttranslational modification]
444177005521	intermolecular recognition site; other site
444177005522	dimerization interface [polypeptide binding]; other site
444177005523	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
444177005524	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
444177005525	Walker A/P-loop; other site
444177005526	ATP binding site [chemical binding]; other site
444177005527	Q-loop/lid; other site
444177005528	ABC transporter signature motif; other site
444177005529	Walker B; other site
444177005530	D-loop; other site
444177005531	H-loop/switch region; other site
444177005532	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
444177005533	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
444177005534	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
444177005535	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
444177005536	Walker A/P-loop; other site
444177005537	ATP binding site [chemical binding]; other site
444177005538	Q-loop/lid; other site
444177005539	ABC transporter signature motif; other site
444177005540	Walker B; other site
444177005541	D-loop; other site
444177005542	H-loop/switch region; other site
444177005543	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177005544	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177005545	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
444177005546	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
444177005547	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
444177005548	Domain of unknown function (DUF955); Region: DUF955; pfam06114
444177005549	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
444177005550	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177005551	non-specific DNA binding site [nucleotide binding]; other site
444177005552	salt bridge; other site
444177005553	sequence-specific DNA binding site [nucleotide binding]; other site
444177005554	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177005555	sequence-specific DNA binding site [nucleotide binding]; other site
444177005556	salt bridge; other site
444177005557	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
444177005558	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
444177005559	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
444177005560	Phage XkdN-like protein; Region: XkdN; pfam08890
444177005561	Phage-related protein [Function unknown]; Region: COG5412
444177005562	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177005563	Protein of unknown function (DUF2577); Region: DUF2577; pfam10844
444177005564	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
444177005565	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
444177005566	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
444177005567	Haemolysin XhlA; Region: XhlA; pfam10779
444177005568	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
444177005569	amidase catalytic site [active]
444177005570	Zn binding residues [ion binding]; other site
444177005571	substrate binding site [chemical binding]; other site
444177005572	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
444177005573	Peptidase family M23; Region: Peptidase_M23; pfam01551
444177005574	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
444177005575	Homeodomain-like domain; Region: HTH_23; pfam13384
444177005576	Helix-turn-helix domain; Region: HTH_28; pfam13518
444177005577	Integrase core domain; Region: rve; pfam00665
444177005578	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177005579	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177005580	dimer interface [polypeptide binding]; other site
444177005581	phosphorylation site [posttranslational modification]
444177005582	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
444177005583	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
444177005584	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
444177005585	PhoU domain; Region: PhoU; pfam01895
444177005586	PhoU domain; Region: PhoU; pfam01895
444177005587	Uncharacterized conserved protein [Function unknown]; Region: COG1284
444177005588	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
444177005589	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
444177005590	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177005591	dimerization interface [polypeptide binding]; other site
444177005592	putative DNA binding site [nucleotide binding]; other site
444177005593	putative Zn2+ binding site [ion binding]; other site
444177005594	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
444177005595	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177005596	Walker A/P-loop; other site
444177005597	ATP binding site [chemical binding]; other site
444177005598	Q-loop/lid; other site
444177005599	ABC transporter signature motif; other site
444177005600	Walker B; other site
444177005601	D-loop; other site
444177005602	H-loop/switch region; other site
444177005603	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
444177005604	Predicted transcriptional regulators [Transcription]; Region: COG1725
444177005605	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177005606	DNA-binding site [nucleotide binding]; DNA binding site
444177005607	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
444177005608	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
444177005609	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
444177005610	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
444177005611	metal binding site [ion binding]; metal-binding site
444177005612	dimer interface [polypeptide binding]; other site
444177005613	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
444177005614	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
444177005615	active site
444177005616	NAD binding site [chemical binding]; other site
444177005617	metal binding site [ion binding]; metal-binding site
444177005618	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
444177005619	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
444177005620	NAD(P) binding site [chemical binding]; other site
444177005621	catalytic residues [active]
444177005622	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
444177005623	Na binding site [ion binding]; other site
444177005624	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177005625	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177005626	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
444177005627	Beta-lactamase; Region: Beta-lactamase; pfam00144
444177005628	Transcriptional regulators [Transcription]; Region: GntR; COG1802
444177005629	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177005630	DNA-binding site [nucleotide binding]; DNA binding site
444177005631	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
444177005632	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
444177005633	putative NAD(P) binding site [chemical binding]; other site
444177005634	catalytic Zn binding site [ion binding]; other site
444177005635	Predicted membrane protein [Function unknown]; Region: COG4682
444177005636	yiaA/B two helix domain; Region: YiaAB; pfam05360
444177005637	yiaA/B two helix domain; Region: YiaAB; pfam05360
444177005638	PGAP1-like protein; Region: PGAP1; pfam07819
444177005639	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177005640	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177005641	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177005642	Spore germination protein; Region: Spore_permease; cl17796
444177005643	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177005644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177005645	active site
444177005646	phosphorylation site [posttranslational modification]
444177005647	intermolecular recognition site; other site
444177005648	dimerization interface [polypeptide binding]; other site
444177005649	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
444177005650	Mga helix-turn-helix domain; Region: Mga; pfam05043
444177005651	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
444177005652	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177005653	dimerization interface [polypeptide binding]; other site
444177005654	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177005655	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177005656	dimer interface [polypeptide binding]; other site
444177005657	putative CheW interface [polypeptide binding]; other site
444177005658	Methyltransferase domain; Region: Methyltransf_18; pfam12847
444177005659	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
444177005660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
444177005661	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177005662	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177005663	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
444177005664	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177005665	intersubunit interface [polypeptide binding]; other site
444177005666	Cupin domain; Region: Cupin_2; cl17218
444177005667	TM2 domain; Region: TM2; pfam05154
444177005668	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
444177005669	S-layer homology domain; Region: SLH; pfam00395
444177005670	S-layer homology domain; Region: SLH; pfam00395
444177005671	S-layer homology domain; Region: SLH; pfam00395
444177005672	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
444177005673	generic binding surface II; other site
444177005674	generic binding surface I; other site
444177005675	Fn3 associated; Region: Fn3_assoc; pfam13287
444177005676	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
444177005677	generic binding surface II; other site
444177005678	generic binding surface I; other site
444177005679	Fn3 associated; Region: Fn3_assoc; pfam13287
444177005680	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
444177005681	generic binding surface I; other site
444177005682	generic binding surface II; other site
444177005683	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
444177005684	putative catalytic site [active]
444177005685	putative metal binding site [ion binding]; other site
444177005686	putative phosphate binding site [ion binding]; other site
444177005687	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
444177005688	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
444177005689	Glutaredoxin; Region: Glutaredoxin; pfam00462
444177005690	NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972
444177005691	ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Region: RNR_1b_NrdE; TIGR04170
444177005692	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
444177005693	Class I ribonucleotide reductase; Region: RNR_I; cd01679
444177005694	active site
444177005695	dimer interface [polypeptide binding]; other site
444177005696	catalytic residues [active]
444177005697	effector binding site; other site
444177005698	R2 peptide binding site; other site
444177005699	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
444177005700	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
444177005701	dimer interface [polypeptide binding]; other site
444177005702	putative radical transfer pathway; other site
444177005703	diiron center [ion binding]; other site
444177005704	tyrosyl radical; other site
444177005705	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
444177005706	trimer interface [polypeptide binding]; other site
444177005707	active site
444177005708	Ferredoxin [Energy production and conversion]; Region: COG1146
444177005709	4Fe-4S binding domain; Region: Fer4; pfam00037
444177005710	YwhD family; Region: YwhD; pfam08741
444177005711	S-layer homology domain; Region: SLH; pfam00395
444177005712	S-layer homology domain; Region: SLH; pfam00395
444177005713	S-layer homology domain; Region: SLH; pfam00395
444177005714	Acyltransferase family; Region: Acyl_transf_3; pfam01757
444177005715	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
444177005716	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
444177005717	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
444177005718	putative NADP binding site [chemical binding]; other site
444177005719	putative dimer interface [polypeptide binding]; other site
444177005720	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177005721	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177005722	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
444177005723	agmatinase; Region: agmatinase; TIGR01230
444177005724	Arginase family; Region: Arginase; cd09989
444177005725	active site
444177005726	Mn binding site [ion binding]; other site
444177005727	oligomer interface [polypeptide binding]; other site
444177005728	S-methylmethionine transporter; Provisional; Region: PRK11387
444177005729	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
444177005730	Protein of unknown function (DUF817); Region: DUF817; pfam05675
444177005731	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
444177005732	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177005733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177005734	active site
444177005735	phosphorylation site [posttranslational modification]
444177005736	intermolecular recognition site; other site
444177005737	dimerization interface [polypeptide binding]; other site
444177005738	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177005739	DNA binding site [nucleotide binding]
444177005740	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177005741	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177005742	dimer interface [polypeptide binding]; other site
444177005743	phosphorylation site [posttranslational modification]
444177005744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177005745	ATP binding site [chemical binding]; other site
444177005746	Mg2+ binding site [ion binding]; other site
444177005747	G-X-G motif; other site
444177005748	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
444177005749	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
444177005750	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177005751	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
444177005752	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
444177005753	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
444177005754	putative dimer interface [polypeptide binding]; other site
444177005755	Repeat domain of CamS sex pheromone cAM373 precursor and related proteins; Region: CamS_repeat; cl17505
444177005756	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
444177005757	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
444177005758	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177005759	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177005760	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177005761	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
444177005762	classical (c) SDRs; Region: SDR_c; cd05233
444177005763	NAD(P) binding site [chemical binding]; other site
444177005764	active site
444177005765	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
444177005766	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177005767	dimerization interface [polypeptide binding]; other site
444177005768	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177005769	dimer interface [polypeptide binding]; other site
444177005770	putative CheW interface [polypeptide binding]; other site
444177005771	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
444177005772	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
444177005773	ligand binding site [chemical binding]; other site
444177005774	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177005775	ATP-grasp domain; Region: ATP-grasp_4; cl17255
444177005776	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
444177005777	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
444177005778	active site
444177005779	P-loop; other site
444177005780	phosphorylation site [posttranslational modification]
444177005781	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
444177005782	active site
444177005783	phosphorylation site [posttranslational modification]
444177005784	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177005785	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
444177005786	dimerization interface [polypeptide binding]; other site
444177005787	Peptidase family M48; Region: Peptidase_M48; pfam01435
444177005788	Uncharacterized conserved protein [Function unknown]; Region: COG1284
444177005789	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
444177005790	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
444177005791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
444177005792	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
444177005793	GIY-YIG motif/motif A; other site
444177005794	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
444177005795	DNA binding residues [nucleotide binding]
444177005796	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
444177005797	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
444177005798	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177005799	Walker A/P-loop; other site
444177005800	ATP binding site [chemical binding]; other site
444177005801	Q-loop/lid; other site
444177005802	ABC transporter signature motif; other site
444177005803	Walker B; other site
444177005804	D-loop; other site
444177005805	H-loop/switch region; other site
444177005806	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
444177005807	LytTr DNA-binding domain; Region: LytTR; cl04498
444177005808	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
444177005809	Putative ammonia monooxygenase; Region: AmoA; pfam05145
444177005810	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
444177005811	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
444177005812	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177005813	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177005814	ABC transporter; Region: ABC_tran_2; pfam12848
444177005815	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177005816	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177005817	Coenzyme A binding pocket [chemical binding]; other site
444177005818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
444177005819	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
444177005820	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
444177005821	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
444177005822	S-layer homology domain; Region: SLH; pfam00395
444177005823	S-layer homology domain; Region: SLH; pfam00395
444177005824	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177005825	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177005826	Coenzyme A binding pocket [chemical binding]; other site
444177005827	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177005828	dimer interface [polypeptide binding]; other site
444177005829	putative CheW interface [polypeptide binding]; other site
444177005830	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177005831	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177005832	putative substrate translocation pore; other site
444177005833	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
444177005834	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
444177005835	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
444177005836	NAD binding site [chemical binding]; other site
444177005837	homotetramer interface [polypeptide binding]; other site
444177005838	homodimer interface [polypeptide binding]; other site
444177005839	substrate binding site [chemical binding]; other site
444177005840	active site
444177005841	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
444177005842	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
444177005843	DEAD-like helicases superfamily; Region: DEXDc; smart00487
444177005844	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
444177005845	ATP binding site [chemical binding]; other site
444177005846	putative Mg++ binding site [ion binding]; other site
444177005847	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177005848	nucleotide binding region [chemical binding]; other site
444177005849	ATP-binding site [chemical binding]; other site
444177005850	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
444177005851	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177005852	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
444177005853	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
444177005854	active site
444177005855	metal binding site [ion binding]; metal-binding site
444177005856	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
444177005857	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
444177005858	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
444177005859	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
444177005860	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
444177005861	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
444177005862	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177005863	catalytic residue [active]
444177005864	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
444177005865	active site
444177005866	homotetramer interface [polypeptide binding]; other site
444177005867	homodimer interface [polypeptide binding]; other site
444177005868	Protease prsW family; Region: PrsW-protease; pfam13367
444177005869	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
444177005870	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
444177005871	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
444177005872	germination protein YpeB; Region: spore_YpeB; TIGR02889
444177005873	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
444177005874	Flagellar protein YcgR; Region: YcgR_2; pfam12945
444177005875	PilZ domain; Region: PilZ; pfam07238
444177005876	cytidylate kinase; Provisional; Region: cmk; PRK00023
444177005877	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
444177005878	CMP-binding site; other site
444177005879	The sites determining sugar specificity; other site
444177005880	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
444177005881	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
444177005882	RNA binding site [nucleotide binding]; other site
444177005883	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
444177005884	RNA binding site [nucleotide binding]; other site
444177005885	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
444177005886	RNA binding site [nucleotide binding]; other site
444177005887	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
444177005888	RNA binding site [nucleotide binding]; other site
444177005889	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
444177005890	G1 box; other site
444177005891	GTP/Mg2+ binding site [chemical binding]; other site
444177005892	Switch I region; other site
444177005893	G2 box; other site
444177005894	Switch II region; other site
444177005895	G3 box; other site
444177005896	G4 box; other site
444177005897	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
444177005898	G1 box; other site
444177005899	GTP/Mg2+ binding site [chemical binding]; other site
444177005900	GTP-binding protein Der; Reviewed; Region: PRK00093
444177005901	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
444177005902	G2 box; other site
444177005903	G3 box; other site
444177005904	Switch II region; other site
444177005905	GTP/Mg2+ binding site [chemical binding]; other site
444177005906	G4 box; other site
444177005907	G5 box; other site
444177005908	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
444177005909	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
444177005910	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
444177005911	Protein of unknown function (DUF2768); Region: DUF2768; pfam10966
444177005912	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
444177005913	IHF dimer interface [polypeptide binding]; other site
444177005914	IHF - DNA interface [nucleotide binding]; other site
444177005915	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
444177005916	homodecamer interface [polypeptide binding]; other site
444177005917	GTP cyclohydrolase I; Provisional; Region: PLN03044
444177005918	active site
444177005919	putative catalytic site residues [active]
444177005920	zinc binding site [ion binding]; other site
444177005921	GTP-CH-I/GFRP interaction surface; other site
444177005922	transcription attenuation protein MtrB; Provisional; Region: PRK13251
444177005923	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
444177005924	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
444177005925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177005926	S-adenosylmethionine binding site [chemical binding]; other site
444177005927	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
444177005928	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
444177005929	substrate binding pocket [chemical binding]; other site
444177005930	chain length determination region; other site
444177005931	substrate-Mg2+ binding site; other site
444177005932	catalytic residues [active]
444177005933	aspartate-rich region 1; other site
444177005934	active site lid residues [active]
444177005935	aspartate-rich region 2; other site
444177005936	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
444177005937	active site
444177005938	multimer interface [polypeptide binding]; other site
444177005939	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
444177005940	active site
444177005941	catalytic residues [active]
444177005942	DNA binding site [nucleotide binding]
444177005943	Int/Topo IB signature motif; other site
444177005944	large terminase protein; Provisional; Region: 17; PHA02533
444177005945	Terminase-like family; Region: Terminase_6; pfam03237
444177005946	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
444177005947	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
444177005948	Holin family; Region: Phage_holin_4; pfam05105
444177005949	Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335
444177005950	active site
444177005951	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
444177005952	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
444177005953	dimer interface [polypeptide binding]; other site
444177005954	active site
444177005955	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
444177005956	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
444177005957	NAD binding site [chemical binding]; other site
444177005958	homodimer interface [polypeptide binding]; other site
444177005959	homotetramer interface [polypeptide binding]; other site
444177005960	active site
444177005961	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
444177005962	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
444177005963	dimer interface [polypeptide binding]; other site
444177005964	acyl-activating enzyme (AAE) consensus motif; other site
444177005965	putative active site [active]
444177005966	AMP binding site [chemical binding]; other site
444177005967	putative CoA binding site [chemical binding]; other site
444177005968	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
444177005969	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
444177005970	Tetramer interface [polypeptide binding]; other site
444177005971	active site
444177005972	FMN-binding site [chemical binding]; other site
444177005973	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
444177005974	active site
444177005975	dimer interface [polypeptide binding]; other site
444177005976	metal binding site [ion binding]; metal-binding site
444177005977	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
444177005978	homotrimer interaction site [polypeptide binding]; other site
444177005979	active site
444177005980	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
444177005981	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177005982	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177005983	homodimer interface [polypeptide binding]; other site
444177005984	catalytic residue [active]
444177005985	prephenate dehydrogenase; Validated; Region: PRK08507
444177005986	prephenate dehydrogenase; Validated; Region: PRK06545
444177005987	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
444177005988	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
444177005989	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
444177005990	putative active site [active]
444177005991	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177005992	binding surface
444177005993	Tetratricopeptide repeat; Region: TPR_16; pfam13432
444177005994	TPR motif; other site
444177005995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177005996	TPR motif; other site
444177005997	binding surface
444177005998	TPR repeat; Region: TPR_11; pfam13414
444177005999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177006000	binding surface
444177006001	TPR motif; other site
444177006002	hypothetical protein; Provisional; Region: PRK03636
444177006003	UPF0302 domain; Region: UPF0302; pfam08864
444177006004	IDEAL domain; Region: IDEAL; pfam08858
444177006005	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
444177006006	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
444177006007	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
444177006008	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
444177006009	iron-sulfur cluster [ion binding]; other site
444177006010	[2Fe-2S] cluster binding site [ion binding]; other site
444177006011	cytochrome b6; Provisional; Region: PRK03735
444177006012	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
444177006013	interchain domain interface [polypeptide binding]; other site
444177006014	intrachain domain interface; other site
444177006015	heme bH binding site [chemical binding]; other site
444177006016	Qi binding site; other site
444177006017	heme bL binding site [chemical binding]; other site
444177006018	Qo binding site; other site
444177006019	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
444177006020	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
444177006021	interchain domain interface [polypeptide binding]; other site
444177006022	intrachain domain interface; other site
444177006023	Qi binding site; other site
444177006024	Qo binding site; other site
444177006025	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
444177006026	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
444177006027	Protein of unknown function (DUF1405); Region: DUF1405; pfam07187
444177006028	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
444177006029	Uncharacterized conserved protein [Function unknown]; Region: COG1284
444177006030	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
444177006031	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
444177006032	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
444177006033	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
444177006034	homodimer interface [polypeptide binding]; other site
444177006035	metal binding site [ion binding]; metal-binding site
444177006036	dihydrodipicolinate reductase; Provisional; Region: PRK00048
444177006037	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
444177006038	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
444177006039	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
444177006040	active site
444177006041	dimer interfaces [polypeptide binding]; other site
444177006042	catalytic residues [active]
444177006043	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
444177006044	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
444177006045	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
444177006046	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
444177006047	active site
444177006048	NTP binding site [chemical binding]; other site
444177006049	metal binding triad [ion binding]; metal-binding site
444177006050	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
444177006051	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
444177006052	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177006053	DNA-binding site [nucleotide binding]; DNA binding site
444177006054	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
444177006055	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
444177006056	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
444177006057	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
444177006058	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
444177006059	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
444177006060	Predicted transcriptional regulators [Transcription]; Region: COG1695
444177006061	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
444177006062	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
444177006063	oligomerization interface [polypeptide binding]; other site
444177006064	active site
444177006065	metal binding site [ion binding]; metal-binding site
444177006066	pantoate--beta-alanine ligase; Region: panC; TIGR00018
444177006067	Pantoate-beta-alanine ligase; Region: PanC; cd00560
444177006068	active site
444177006069	ATP-binding site [chemical binding]; other site
444177006070	pantoate-binding site; other site
444177006071	HXXH motif; other site
444177006072	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
444177006073	tetramerization interface [polypeptide binding]; other site
444177006074	active site
444177006075	S-layer homology domain; Region: SLH; pfam00395
444177006076	S-layer homology domain; Region: SLH; pfam00395
444177006077	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
444177006078	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
444177006079	active site
444177006080	metal binding site [ion binding]; metal-binding site
444177006081	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
444177006082	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
444177006083	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
444177006084	active site
444177006085	catalytic site [active]
444177006086	substrate binding site [chemical binding]; other site
444177006087	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
444177006088	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
444177006089	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177006090	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177006091	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177006092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
444177006093	putative substrate translocation pore; other site
444177006094	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
444177006095	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
444177006096	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177006097	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177006098	metal binding site [ion binding]; metal-binding site
444177006099	active site
444177006100	I-site; other site
444177006101	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
444177006102	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
444177006103	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177006104	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177006105	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177006106	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
444177006107	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
444177006108	DNA binding site [nucleotide binding]
444177006109	active site
444177006110	Domain of unknown function (DUF378); Region: DUF378; pfam04070
444177006111	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
444177006112	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
444177006113	tetrameric interface [polypeptide binding]; other site
444177006114	NAD binding site [chemical binding]; other site
444177006115	catalytic residues [active]
444177006116	aminotransferase; Validated; Region: PRK07678
444177006117	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
444177006118	inhibitor-cofactor binding pocket; inhibition site
444177006119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177006120	catalytic residue [active]
444177006121	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
444177006122	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
444177006123	allantoate amidohydrolase; Reviewed; Region: PRK09290
444177006124	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
444177006125	active site
444177006126	metal binding site [ion binding]; metal-binding site
444177006127	dimer interface [polypeptide binding]; other site
444177006128	phenylhydantoinase; Validated; Region: PRK08323
444177006129	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
444177006130	tetramer interface [polypeptide binding]; other site
444177006131	active site
444177006132	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
444177006133	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
444177006134	homodimer interface [polypeptide binding]; other site
444177006135	active site
444177006136	FMN binding site [chemical binding]; other site
444177006137	substrate binding site [chemical binding]; other site
444177006138	4Fe-4S binding domain; Region: Fer4; pfam00037
444177006139	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
444177006140	putative transport protein YifK; Provisional; Region: PRK10746
444177006141	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177006142	Spore germination protein; Region: Spore_permease; cl17796
444177006143	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177006144	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177006145	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
444177006146	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177006147	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
444177006148	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
444177006149	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
444177006150	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
444177006151	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
444177006152	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
444177006153	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
444177006154	VanW like protein; Region: VanW; pfam04294
444177006155	S-layer homology domain; Region: SLH; pfam00395
444177006156	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177006157	dimer interface [polypeptide binding]; other site
444177006158	putative CheW interface [polypeptide binding]; other site
444177006159	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
444177006160	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177006161	motif II; other site
444177006162	YibE/F-like protein; Region: YibE_F; pfam07907
444177006163	YibE/F-like protein; Region: YibE_F; pfam07907
444177006164	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
444177006165	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177006166	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177006167	ABC transporter; Region: ABC_tran_2; pfam12848
444177006168	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177006169	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
444177006170	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
444177006171	Lumazine binding domain; Region: Lum_binding; pfam00677
444177006172	Lumazine binding domain; Region: Lum_binding; pfam00677
444177006173	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
444177006174	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
444177006175	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
444177006176	homopentamer interface [polypeptide binding]; other site
444177006177	active site
444177006178	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177006179	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177006180	ATP binding site [chemical binding]; other site
444177006181	Mg2+ binding site [ion binding]; other site
444177006182	G-X-G motif; other site
444177006183	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
444177006184	catalytic core [active]
444177006185	putative acetyltransferase; Provisional; Region: PRK03624
444177006186	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177006187	Coenzyme A binding pocket [chemical binding]; other site
444177006188	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
444177006189	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
444177006190	classical (c) SDRs; Region: SDR_c; cd05233
444177006191	NAD(P) binding site [chemical binding]; other site
444177006192	active site
444177006193	QueT transporter; Region: QueT; pfam06177
444177006194	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177006195	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
444177006196	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
444177006197	Transcriptional regulator protein (SplA); Region: SplA; pfam11132
444177006198	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
444177006199	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177006200	FeS/SAM binding site; other site
444177006201	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
444177006202	Amidinotransferase; Region: Amidinotransf; cl12043
444177006203	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
444177006204	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
444177006205	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177006206	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177006207	putative DNA binding site [nucleotide binding]; other site
444177006208	putative Zn2+ binding site [ion binding]; other site
444177006209	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
444177006210	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
444177006211	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177006212	dimerization interface [polypeptide binding]; other site
444177006213	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177006214	dimer interface [polypeptide binding]; other site
444177006215	phosphorylation site [posttranslational modification]
444177006216	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177006217	ATP binding site [chemical binding]; other site
444177006218	Mg2+ binding site [ion binding]; other site
444177006219	G-X-G motif; other site
444177006220	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177006221	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177006222	active site
444177006223	phosphorylation site [posttranslational modification]
444177006224	intermolecular recognition site; other site
444177006225	dimerization interface [polypeptide binding]; other site
444177006226	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177006227	DNA binding site [nucleotide binding]
444177006228	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
444177006229	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
444177006230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177006231	Walker A/P-loop; other site
444177006232	ATP binding site [chemical binding]; other site
444177006233	Q-loop/lid; other site
444177006234	ABC transporter signature motif; other site
444177006235	Walker B; other site
444177006236	D-loop; other site
444177006237	H-loop/switch region; other site
444177006238	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
444177006239	H+ Antiporter protein; Region: 2A0121; TIGR00900
444177006240	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177006241	putative substrate translocation pore; other site
444177006242	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
444177006243	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
444177006244	Multicopper oxidase; Region: Cu-oxidase; pfam00394
444177006245	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
444177006246	Tetratricopeptide repeat; Region: TPR_12; pfam13424
444177006247	Tetratricopeptide repeat; Region: TPR_12; pfam13424
444177006248	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177006249	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177006250	metal binding site [ion binding]; metal-binding site
444177006251	active site
444177006252	I-site; other site
444177006253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
444177006254	aspartate aminotransferase; Provisional; Region: PRK05764
444177006255	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177006256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177006257	homodimer interface [polypeptide binding]; other site
444177006258	catalytic residue [active]
444177006259	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
444177006260	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
444177006261	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
444177006262	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
444177006263	minor groove reading motif; other site
444177006264	helix-hairpin-helix signature motif; other site
444177006265	substrate binding pocket [chemical binding]; other site
444177006266	active site
444177006267	Transglycosylase; Region: Transgly; pfam00912
444177006268	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
444177006269	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
444177006270	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
444177006271	Interdomain contacts; other site
444177006272	Cytokine receptor motif; other site
444177006273	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
444177006274	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
444177006275	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
444177006276	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
444177006277	ATP binding site [chemical binding]; other site
444177006278	putative Mg++ binding site [ion binding]; other site
444177006279	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177006280	nucleotide binding region [chemical binding]; other site
444177006281	ATP-binding site [chemical binding]; other site
444177006282	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
444177006283	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
444177006284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177006285	Coenzyme A binding pocket [chemical binding]; other site
444177006286	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
444177006287	Phage Tail Collar Domain; Region: Collar; pfam07484
444177006288	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
444177006289	Phage Tail Collar Domain; Region: Collar; pfam07484
444177006290	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
444177006291	Phage Tail Collar Domain; Region: Collar; pfam07484
444177006292	Fibronectin type 3 domain; Region: FN3; smart00060
444177006293	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
444177006294	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
444177006295	Interdomain contacts; other site
444177006296	Cytokine receptor motif; other site
444177006297	S-layer homology domain; Region: SLH; pfam00395
444177006298	S-layer homology domain; Region: SLH; pfam00395
444177006299	RNase_H superfamily; Region: RNase_H_2; pfam13482
444177006300	DivIVA protein; Region: DivIVA; pfam05103
444177006301	DivIVA domain; Region: DivI1A_domain; TIGR03544
444177006302	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177006303	PAS domain; Region: PAS_9; pfam13426
444177006304	putative active site [active]
444177006305	heme pocket [chemical binding]; other site
444177006306	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177006307	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177006308	metal binding site [ion binding]; metal-binding site
444177006309	active site
444177006310	I-site; other site
444177006311	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
444177006312	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
444177006313	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
444177006314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
444177006315	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
444177006316	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
444177006317	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
444177006318	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
444177006319	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
444177006320	Histidine kinase; Region: HisKA_2; pfam07568
444177006321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177006322	ATP binding site [chemical binding]; other site
444177006323	Mg2+ binding site [ion binding]; other site
444177006324	G-X-G motif; other site
444177006325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177006326	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
444177006327	active site
444177006328	phosphorylation site [posttranslational modification]
444177006329	intermolecular recognition site; other site
444177006330	dimerization interface [polypeptide binding]; other site
444177006331	ANTAR domain; Region: ANTAR; pfam03861
444177006332	ethanolamine utilization protein EutH; Provisional; Region: PRK15086
444177006333	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
444177006334	putative hexamer interface [polypeptide binding]; other site
444177006335	putative hexagonal pore; other site
444177006336	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
444177006337	G1 box; other site
444177006338	GTP/Mg2+ binding site [chemical binding]; other site
444177006339	G2 box; other site
444177006340	Switch I region; other site
444177006341	G3 box; other site
444177006342	Switch II region; other site
444177006343	G4 box; other site
444177006344	G5 box; other site
444177006345	Ethanolamine utilisation protein EutA; Region: EutA; pfam06277
444177006346	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
444177006347	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
444177006348	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985
444177006349	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
444177006350	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
444177006351	putative hexamer interface [polypeptide binding]; other site
444177006352	putative hexagonal pore; other site
444177006353	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
444177006354	putative hexamer interface [polypeptide binding]; other site
444177006355	putative hexagonal pore; other site
444177006356	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
444177006357	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
444177006358	putative catalytic cysteine [active]
444177006359	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
444177006360	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
444177006361	Hexamer interface [polypeptide binding]; other site
444177006362	Putative hexagonal pore residue; other site
444177006363	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
444177006364	Propanediol utilisation protein PduL; Region: PduL; pfam06130
444177006365	Propanediol utilisation protein PduL; Region: PduL; pfam06130
444177006366	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
444177006367	Propanediol utilisation protein PduL; Region: PduL; pfam06130
444177006368	Propanediol utilisation protein PduL; Region: PduL; pfam06130
444177006369	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
444177006370	Hexamer/Pentamer interface [polypeptide binding]; other site
444177006371	central pore; other site
444177006372	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
444177006373	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
444177006374	Hexamer interface [polypeptide binding]; other site
444177006375	Hexagonal pore residue; other site
444177006376	malate dehydrogenase; Reviewed; Region: PRK06223
444177006377	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
444177006378	NAD(P) binding site [chemical binding]; other site
444177006379	dimer interface [polypeptide binding]; other site
444177006380	tetramer (dimer of dimers) interface [polypeptide binding]; other site
444177006381	substrate binding site [chemical binding]; other site
444177006382	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
444177006383	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
444177006384	active site
444177006385	Zn binding site [ion binding]; other site
444177006386	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
444177006387	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
444177006388	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
444177006389	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
444177006390	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177006391	Walker A/P-loop; other site
444177006392	ATP binding site [chemical binding]; other site
444177006393	Q-loop/lid; other site
444177006394	ABC transporter signature motif; other site
444177006395	Walker B; other site
444177006396	D-loop; other site
444177006397	H-loop/switch region; other site
444177006398	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
444177006399	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177006400	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
444177006401	Walker A/P-loop; other site
444177006402	ATP binding site [chemical binding]; other site
444177006403	Q-loop/lid; other site
444177006404	ABC transporter signature motif; other site
444177006405	Walker B; other site
444177006406	D-loop; other site
444177006407	H-loop/switch region; other site
444177006408	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
444177006409	Transcriptional regulator [Transcription]; Region: IclR; COG1414
444177006410	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
444177006411	Bacterial transcriptional regulator; Region: IclR; pfam01614
444177006412	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
444177006413	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
444177006414	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177006415	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177006416	dimer interface [polypeptide binding]; other site
444177006417	conserved gate region; other site
444177006418	putative PBP binding loops; other site
444177006419	ABC-ATPase subunit interface; other site
444177006420	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
444177006421	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177006422	dimer interface [polypeptide binding]; other site
444177006423	conserved gate region; other site
444177006424	putative PBP binding loops; other site
444177006425	ABC-ATPase subunit interface; other site
444177006426	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_5; cd06232
444177006427	putative active site [active]
444177006428	Zn binding site [ion binding]; other site
444177006429	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
444177006430	putative substrate binding pocket [chemical binding]; other site
444177006431	AC domain interface; other site
444177006432	catalytic triad [active]
444177006433	AB domain interface; other site
444177006434	interchain disulfide; other site
444177006435	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
444177006436	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
444177006437	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
444177006438	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
444177006439	putative active site [active]
444177006440	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
444177006441	active site
444177006442	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
444177006443	Transcriptional regulator [Transcription]; Region: LytR; COG1316
444177006444	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177006445	sequence-specific DNA binding site [nucleotide binding]; other site
444177006446	salt bridge; other site
444177006447	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
444177006448	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
444177006449	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
444177006450	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
444177006451	FtsX-like permease family; Region: FtsX; pfam02687
444177006452	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
444177006453	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
444177006454	Walker A/P-loop; other site
444177006455	ATP binding site [chemical binding]; other site
444177006456	Q-loop/lid; other site
444177006457	ABC transporter signature motif; other site
444177006458	Walker B; other site
444177006459	D-loop; other site
444177006460	H-loop/switch region; other site
444177006461	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177006462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177006463	active site
444177006464	phosphorylation site [posttranslational modification]
444177006465	intermolecular recognition site; other site
444177006466	dimerization interface [polypeptide binding]; other site
444177006467	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177006468	DNA binding site [nucleotide binding]
444177006469	HAMP domain; Region: HAMP; pfam00672
444177006470	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177006471	dimer interface [polypeptide binding]; other site
444177006472	phosphorylation site [posttranslational modification]
444177006473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177006474	ATP binding site [chemical binding]; other site
444177006475	Mg2+ binding site [ion binding]; other site
444177006476	G-X-G motif; other site
444177006477	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
444177006478	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
444177006479	dimerization interface [polypeptide binding]; other site
444177006480	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177006481	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177006482	dimer interface [polypeptide binding]; other site
444177006483	putative CheW interface [polypeptide binding]; other site
444177006484	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
444177006485	glutamyl-tRNA(Gln) amidotransferase subunit E; Validated; Region: PRK04028
444177006486	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
444177006487	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
444177006488	Dynamin family; Region: Dynamin_N; pfam00350
444177006489	G1 box; other site
444177006490	GTP/Mg2+ binding site [chemical binding]; other site
444177006491	G2 box; other site
444177006492	Switch I region; other site
444177006493	G3 box; other site
444177006494	Switch II region; other site
444177006495	G4 box; other site
444177006496	G5 box; other site
444177006497	Dynamin family; Region: Dynamin_N; pfam00350
444177006498	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
444177006499	G3 box; other site
444177006500	Switch II region; other site
444177006501	GTP/Mg2+ binding site [chemical binding]; other site
444177006502	G4 box; other site
444177006503	G5 box; other site
444177006504	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
444177006505	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
444177006506	active site residue [active]
444177006507	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
444177006508	active site residue [active]
444177006509	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177006510	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
444177006511	Malic enzyme, N-terminal domain; Region: malic; pfam00390
444177006512	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
444177006513	putative NAD(P) binding site [chemical binding]; other site
444177006514	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
444177006515	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177006516	dimerization interface [polypeptide binding]; other site
444177006517	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177006518	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177006519	dimer interface [polypeptide binding]; other site
444177006520	putative CheW interface [polypeptide binding]; other site
444177006521	Yip1 domain; Region: Yip1; pfam04893
444177006522	5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231
444177006523	ATP binding site [chemical binding]; other site
444177006524	active site
444177006525	substrate binding site [chemical binding]; other site
444177006526	glutamate dehydrogenase; Provisional; Region: PRK09414
444177006527	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
444177006528	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
444177006529	NAD(P) binding site [chemical binding]; other site
444177006530	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
444177006531	D-serine dehydratase; Provisional; Region: PRK02991
444177006532	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
444177006533	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177006534	catalytic residue [active]
444177006535	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
444177006536	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177006537	catalytic residue [active]
444177006538	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
444177006539	Protein of unknown function; Region: DUF3658; pfam12395
444177006540	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
444177006541	dimer interface [polypeptide binding]; other site
444177006542	FMN binding site [chemical binding]; other site
444177006543	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
444177006544	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
444177006545	FAD binding pocket [chemical binding]; other site
444177006546	FAD binding motif [chemical binding]; other site
444177006547	phosphate binding motif [ion binding]; other site
444177006548	beta-alpha-beta structure motif; other site
444177006549	NAD binding pocket [chemical binding]; other site
444177006550	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
444177006551	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
444177006552	substrate binding pocket [chemical binding]; other site
444177006553	substrate-Mg2+ binding site; other site
444177006554	aspartate-rich region 1; other site
444177006555	aspartate-rich region 2; other site
444177006556	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
444177006557	classical (c) SDRs; Region: SDR_c; cd05233
444177006558	NAD(P) binding site [chemical binding]; other site
444177006559	active site
444177006560	pantothenate kinase; Provisional; Region: PRK13317
444177006561	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
444177006562	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
444177006563	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
444177006564	intracellular protease, PfpI family; Region: PfpI; TIGR01382
444177006565	conserved cys residue [active]
444177006566	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177006567	MarR family; Region: MarR; pfam01047
444177006568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177006569	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177006570	putative substrate translocation pore; other site
444177006571	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
444177006572	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
444177006573	DNA binding residues [nucleotide binding]
444177006574	drug binding residues [chemical binding]; other site
444177006575	dimer interface [polypeptide binding]; other site
444177006576	hypothetical protein; Validated; Region: PRK07581
444177006577	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
444177006578	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177006579	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177006580	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
444177006581	dimerization interface [polypeptide binding]; other site
444177006582	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
444177006583	active site
444177006584	catalytic residues [active]
444177006585	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
444177006586	catalytic residues [active]
444177006587	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
444177006588	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
444177006589	Walker A/P-loop; other site
444177006590	ATP binding site [chemical binding]; other site
444177006591	Q-loop/lid; other site
444177006592	ABC transporter signature motif; other site
444177006593	Walker B; other site
444177006594	D-loop; other site
444177006595	H-loop/switch region; other site
444177006596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177006597	ABC-ATPase subunit interface; other site
444177006598	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
444177006599	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
444177006600	substrate binding pocket [chemical binding]; other site
444177006601	membrane-bound complex binding site; other site
444177006602	hinge residues; other site
444177006603	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
444177006604	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
444177006605	SEC-C motif; Region: SEC-C; pfam02810
444177006606	oligoendopeptidase F; Region: pepF; TIGR00181
444177006607	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
444177006608	active site
444177006609	Zn binding site [ion binding]; other site
444177006610	Ferritin-like domain; Region: Ferritin; pfam00210
444177006611	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
444177006612	dimerization interface [polypeptide binding]; other site
444177006613	DPS ferroxidase diiron center [ion binding]; other site
444177006614	ion pore; other site
444177006615	Heat induced stress protein YflT; Region: YflT; pfam11181
444177006616	EamA-like transporter family; Region: EamA; pfam00892
444177006617	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
444177006618	EamA-like transporter family; Region: EamA; pfam00892
444177006619	hypothetical protein; Provisional; Region: PRK09620
444177006620	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177006621	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177006622	Predicted membrane protein [Function unknown]; Region: COG2311
444177006623	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
444177006624	Protein of unknown function (DUF418); Region: DUF418; pfam04235
444177006625	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
444177006626	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
444177006627	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
444177006628	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
444177006629	DNA-binding site [nucleotide binding]; DNA binding site
444177006630	RNA-binding motif; other site
444177006631	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
444177006632	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
444177006633	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
444177006634	Cesium cation binding sites [ion binding]; other site
444177006635	Potassium binding sites [ion binding]; other site
444177006636	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
444177006637	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
444177006638	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
444177006639	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
444177006640	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
444177006641	Transcriptional regulator [Transcription]; Region: IclR; COG1414
444177006642	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
444177006643	Bacterial transcriptional regulator; Region: IclR; pfam01614
444177006644	OPT oligopeptide transporter protein; Region: OPT; cl14607
444177006645	Protein of unknown function (DUF917); Region: DUF917; pfam06032
444177006646	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
444177006647	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177006648	Zn2+ binding site [ion binding]; other site
444177006649	Mg2+ binding site [ion binding]; other site
444177006650	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
444177006651	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177006652	Walker A/P-loop; other site
444177006653	ATP binding site [chemical binding]; other site
444177006654	Q-loop/lid; other site
444177006655	ABC transporter signature motif; other site
444177006656	Walker B; other site
444177006657	D-loop; other site
444177006658	H-loop/switch region; other site
444177006659	ABC transporter; Region: ABC_tran_2; pfam12848
444177006660	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177006661	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
444177006662	Virulence factor; Region: Virulence_fact; pfam13769
444177006663	HEAT repeats; Region: HEAT_2; pfam13646
444177006664	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
444177006665	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
444177006666	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
444177006667	metal binding site [ion binding]; metal-binding site
444177006668	dimer interface [polypeptide binding]; other site
444177006669	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
444177006670	tartrate dehydrogenase; Provisional; Region: PRK08194
444177006671	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177006672	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
444177006673	NAD(P) binding site [chemical binding]; other site
444177006674	active site
444177006675	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
444177006676	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
444177006677	NAD(P) binding site [chemical binding]; other site
444177006678	catalytic residues [active]
444177006679	catalytic residues [active]
444177006680	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
444177006681	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177006682	Walker A/P-loop; other site
444177006683	ATP binding site [chemical binding]; other site
444177006684	Q-loop/lid; other site
444177006685	ABC transporter signature motif; other site
444177006686	Walker B; other site
444177006687	D-loop; other site
444177006688	H-loop/switch region; other site
444177006689	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
444177006690	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
444177006691	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177006692	Walker A/P-loop; other site
444177006693	ATP binding site [chemical binding]; other site
444177006694	Q-loop/lid; other site
444177006695	ABC transporter signature motif; other site
444177006696	Walker B; other site
444177006697	D-loop; other site
444177006698	H-loop/switch region; other site
444177006699	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
444177006700	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
444177006701	putative active site pocket [active]
444177006702	cleavage site
444177006703	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
444177006704	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516
444177006705	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177006706	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177006707	dimer interface [polypeptide binding]; other site
444177006708	conserved gate region; other site
444177006709	putative PBP binding loops; other site
444177006710	ABC-ATPase subunit interface; other site
444177006711	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
444177006712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177006713	dimer interface [polypeptide binding]; other site
444177006714	conserved gate region; other site
444177006715	putative PBP binding loops; other site
444177006716	ABC-ATPase subunit interface; other site
444177006717	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
444177006718	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
444177006719	aminotransferase; Validated; Region: PRK07678
444177006720	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
444177006721	inhibitor-cofactor binding pocket; inhibition site
444177006722	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177006723	catalytic residue [active]
444177006724	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177006725	MarR family; Region: MarR; pfam01047
444177006726	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177006727	Coenzyme A binding pocket [chemical binding]; other site
444177006728	RDD family; Region: RDD; pfam06271
444177006729	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
444177006730	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
444177006731	putative substrate binding site [chemical binding]; other site
444177006732	putative ATP binding site [chemical binding]; other site
444177006733	EamA-like transporter family; Region: EamA; cl17759
444177006734	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
444177006735	EamA-like transporter family; Region: EamA; cl17759
444177006736	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
444177006737	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
444177006738	putative catalytic cysteine [active]
444177006739	gamma-glutamyl kinase; Provisional; Region: PRK05429
444177006740	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
444177006741	nucleotide binding site [chemical binding]; other site
444177006742	homotetrameric interface [polypeptide binding]; other site
444177006743	putative phosphate binding site [ion binding]; other site
444177006744	putative allosteric binding site; other site
444177006745	PUA domain; Region: PUA; pfam01472
444177006746	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
444177006747	Protein of unknown function; Region: DUF3658; pfam12395
444177006748	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177006749	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
444177006750	putative dimerization interface [polypeptide binding]; other site
444177006751	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177006752	Esterase/lipase [General function prediction only]; Region: COG1647
444177006753	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
444177006754	Esterase/lipase [General function prediction only]; Region: COG1647
444177006755	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
444177006756	classical (c) SDRs; Region: SDR_c; cd05233
444177006757	NAD(P) binding site [chemical binding]; other site
444177006758	active site
444177006759	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
444177006760	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177006761	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
444177006762	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
444177006763	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
444177006764	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177006765	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177006766	Predicted transcriptional regulators [Transcription]; Region: COG1695
444177006767	Transcriptional regulator PadR-like family; Region: PadR; cl17335
444177006768	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
444177006769	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177006770	Walker A/P-loop; other site
444177006771	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177006772	ABC transporter; Region: ABC_tran; pfam00005
444177006773	Q-loop/lid; other site
444177006774	ABC transporter signature motif; other site
444177006775	Walker B; other site
444177006776	D-loop; other site
444177006777	H-loop/switch region; other site
444177006778	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
444177006779	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
444177006780	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
444177006781	Predicted permeases [General function prediction only]; Region: RarD; COG2962
444177006782	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
444177006783	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
444177006784	MutS domain III; Region: MutS_III; pfam05192
444177006785	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177006786	Walker A/P-loop; other site
444177006787	ATP binding site [chemical binding]; other site
444177006788	Q-loop/lid; other site
444177006789	ABC transporter signature motif; other site
444177006790	Walker B; other site
444177006791	D-loop; other site
444177006792	H-loop/switch region; other site
444177006793	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177006794	sequence-specific DNA binding site [nucleotide binding]; other site
444177006795	salt bridge; other site
444177006796	H+ Antiporter protein; Region: 2A0121; TIGR00900
444177006797	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177006798	putative substrate translocation pore; other site
444177006799	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
444177006800	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
444177006801	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
444177006802	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
444177006803	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
444177006804	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
444177006805	Cysteine-rich domain; Region: CCG; pfam02754
444177006806	Cysteine-rich domain; Region: CCG; pfam02754
444177006807	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
444177006808	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
444177006809	Response regulator receiver domain; Region: Response_reg; pfam00072
444177006810	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177006811	active site
444177006812	phosphorylation site [posttranslational modification]
444177006813	intermolecular recognition site; other site
444177006814	dimerization interface [polypeptide binding]; other site
444177006815	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
444177006816	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
444177006817	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
444177006818	YvrJ protein family; Region: YvrJ; pfam12841
444177006819	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
444177006820	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
444177006821	Cu(I) binding site [ion binding]; other site
444177006822	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
444177006823	DinB superfamily; Region: DinB_2; pfam12867
444177006824	CHASE3 domain; Region: CHASE3; cl05000
444177006825	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177006826	dimerization interface [polypeptide binding]; other site
444177006827	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177006828	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177006829	dimer interface [polypeptide binding]; other site
444177006830	putative CheW interface [polypeptide binding]; other site
444177006831	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
444177006832	Cache domain; Region: Cache_1; pfam02743
444177006833	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177006834	dimerization interface [polypeptide binding]; other site
444177006835	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177006836	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177006837	dimer interface [polypeptide binding]; other site
444177006838	putative CheW interface [polypeptide binding]; other site
444177006839	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
444177006840	amino acid carrier protein; Region: agcS; TIGR00835
444177006841	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
444177006842	aspartate racemase; Region: asp_race; TIGR00035
444177006843	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
444177006844	homodimer interface [polypeptide binding]; other site
444177006845	homotetramer interface [polypeptide binding]; other site
444177006846	active site pocket [active]
444177006847	cleavage site
444177006848	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
444177006849	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_3; cd08770
444177006850	SxDxEG motif; other site
444177006851	putative active site [active]
444177006852	putative metal binding site [ion binding]; other site
444177006853	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
444177006854	peptide binding site [polypeptide binding]; other site
444177006855	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
444177006856	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177006857	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177006858	dimer interface [polypeptide binding]; other site
444177006859	conserved gate region; other site
444177006860	putative PBP binding loops; other site
444177006861	ABC-ATPase subunit interface; other site
444177006862	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
444177006863	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177006864	dimer interface [polypeptide binding]; other site
444177006865	conserved gate region; other site
444177006866	putative PBP binding loops; other site
444177006867	ABC-ATPase subunit interface; other site
444177006868	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
444177006869	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177006870	Walker A/P-loop; other site
444177006871	ATP binding site [chemical binding]; other site
444177006872	Q-loop/lid; other site
444177006873	ABC transporter signature motif; other site
444177006874	Walker B; other site
444177006875	D-loop; other site
444177006876	H-loop/switch region; other site
444177006877	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
444177006878	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
444177006879	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177006880	Walker A/P-loop; other site
444177006881	ATP binding site [chemical binding]; other site
444177006882	Q-loop/lid; other site
444177006883	ABC transporter signature motif; other site
444177006884	Walker B; other site
444177006885	D-loop; other site
444177006886	H-loop/switch region; other site
444177006887	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
444177006888	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
444177006889	dimer interface [polypeptide binding]; other site
444177006890	catalytic triad [active]
444177006891	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
444177006892	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
444177006893	NlpC/P60 family; Region: NLPC_P60; pfam00877
444177006894	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
444177006895	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177006896	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
444177006897	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
444177006898	Walker A/P-loop; other site
444177006899	ATP binding site [chemical binding]; other site
444177006900	Q-loop/lid; other site
444177006901	ABC transporter signature motif; other site
444177006902	Walker B; other site
444177006903	D-loop; other site
444177006904	H-loop/switch region; other site
444177006905	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
444177006906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177006907	ABC-ATPase subunit interface; other site
444177006908	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
444177006909	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
444177006910	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177006911	salt bridge; other site
444177006912	non-specific DNA binding site [nucleotide binding]; other site
444177006913	sequence-specific DNA binding site [nucleotide binding]; other site
444177006914	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
444177006915	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
444177006916	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
444177006917	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177006918	motif II; other site
444177006919	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
444177006920	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
444177006921	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
444177006922	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
444177006923	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
444177006924	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
444177006925	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
444177006926	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
444177006927	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
444177006928	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
444177006929	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
444177006930	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
444177006931	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
444177006932	NlpC/P60 family; Region: NLPC_P60; pfam00877
444177006933	NlpC/P60 family; Region: NLPC_P60; cl17555
444177006934	NlpC/P60 family; Region: NLPC_P60; cl17555
444177006935	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
444177006936	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
444177006937	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177006938	dimer interface [polypeptide binding]; other site
444177006939	putative metal binding site [ion binding]; other site
444177006940	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
444177006941	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
444177006942	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
444177006943	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177006944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177006945	active site
444177006946	phosphorylation site [posttranslational modification]
444177006947	intermolecular recognition site; other site
444177006948	dimerization interface [polypeptide binding]; other site
444177006949	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177006950	DNA binding site [nucleotide binding]
444177006951	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
444177006952	Ankyrin repeat; Region: Ank; pfam00023
444177006953	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
444177006954	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
444177006955	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177006956	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177006957	intermolecular recognition site; other site
444177006958	active site
444177006959	dimerization interface [polypeptide binding]; other site
444177006960	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
444177006961	DNA binding residues [nucleotide binding]
444177006962	dimerization interface [polypeptide binding]; other site
444177006963	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177006964	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
444177006965	Domain of unknown function (DUF373); Region: DUF373; cl12079
444177006966	Histidine kinase; Region: HisKA_3; pfam07730
444177006967	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
444177006968	ATP binding site [chemical binding]; other site
444177006969	Mg2+ binding site [ion binding]; other site
444177006970	G-X-G motif; other site
444177006971	Predicted membrane protein [Function unknown]; Region: COG2311
444177006972	Protein of unknown function (DUF418); Region: DUF418; cl12135
444177006973	Protein of unknown function (DUF418); Region: DUF418; pfam04235
444177006974	Methyltransferase domain; Region: Methyltransf_31; pfam13847
444177006975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177006976	S-adenosylmethionine binding site [chemical binding]; other site
444177006977	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
444177006978	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
444177006979	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
444177006980	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
444177006981	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
444177006982	Walker A/P-loop; other site
444177006983	ATP binding site [chemical binding]; other site
444177006984	Q-loop/lid; other site
444177006985	ABC transporter signature motif; other site
444177006986	Walker B; other site
444177006987	D-loop; other site
444177006988	H-loop/switch region; other site
444177006989	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
444177006990	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177006991	ABC-ATPase subunit  interface; other site
444177006992	dimer interface [polypeptide binding]; other site
444177006993	putative PBP binding regions; other site
444177006994	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
444177006995	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177006996	dimer interface [polypeptide binding]; other site
444177006997	putative PBP binding regions; other site
444177006998	ABC-ATPase subunit  interface; other site
444177006999	Nuclease-related domain; Region: NERD; pfam08378
444177007000	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177007001	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177007002	dimerization interface [polypeptide binding]; other site
444177007003	putative Zn2+ binding site [ion binding]; other site
444177007004	putative DNA binding site [nucleotide binding]; other site
444177007005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177007006	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177007007	putative substrate translocation pore; other site
444177007008	Imelysin; Region: Peptidase_M75; pfam09375
444177007009	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
444177007010	Iron permease FTR1 family; Region: FTR1; cl00475
444177007011	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
444177007012	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
444177007013	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
444177007014	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
444177007015	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
444177007016	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
444177007017	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
444177007018	Na binding site [ion binding]; other site
444177007019	Uncharacterized conserved protein [Function unknown]; Region: COG3535
444177007020	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
444177007021	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
444177007022	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
444177007023	Transposase domain (DUF772); Region: DUF772; pfam05598
444177007024	Predicted transcriptional regulators [Transcription]; Region: COG1725
444177007025	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177007026	DNA-binding site [nucleotide binding]; DNA binding site
444177007027	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
444177007028	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
444177007029	Walker A/P-loop; other site
444177007030	ATP binding site [chemical binding]; other site
444177007031	Q-loop/lid; other site
444177007032	ABC transporter signature motif; other site
444177007033	Walker B; other site
444177007034	D-loop; other site
444177007035	H-loop/switch region; other site
444177007036	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
444177007037	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177007038	Walker A/P-loop; other site
444177007039	ATP binding site [chemical binding]; other site
444177007040	Q-loop/lid; other site
444177007041	ABC transporter signature motif; other site
444177007042	Walker B; other site
444177007043	D-loop; other site
444177007044	H-loop/switch region; other site
444177007045	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
444177007046	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
444177007047	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
444177007048	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
444177007049	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
444177007050	active site turn [active]
444177007051	phosphorylation site [posttranslational modification]
444177007052	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
444177007053	HPr interaction site; other site
444177007054	glycerol kinase (GK) interaction site [polypeptide binding]; other site
444177007055	active site
444177007056	phosphorylation site [posttranslational modification]
444177007057	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
444177007058	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
444177007059	active site
444177007060	dimer interface [polypeptide binding]; other site
444177007061	hypothetical protein; Provisional; Region: PRK02947
444177007062	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
444177007063	putative active site [active]
444177007064	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
444177007065	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
444177007066	active site
444177007067	trimer interface [polypeptide binding]; other site
444177007068	allosteric site; other site
444177007069	active site lid [active]
444177007070	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
444177007071	dimerization domain swap beta strand [polypeptide binding]; other site
444177007072	regulatory protein interface [polypeptide binding]; other site
444177007073	active site
444177007074	regulatory phosphorylation site [posttranslational modification]; other site
444177007075	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
444177007076	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
444177007077	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
444177007078	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
444177007079	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
444177007080	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
444177007081	SpoOM protein; Region: Spo0M; pfam07070
444177007082	Family description; Region: DsbD_2; pfam13386
444177007083	multicopper oxidase; Provisional; Region: PRK10965
444177007084	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
444177007085	Multicopper oxidase; Region: Cu-oxidase; pfam00394
444177007086	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
444177007087	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
444177007088	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
444177007089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177007090	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177007091	active site
444177007092	phosphorylation site [posttranslational modification]
444177007093	intermolecular recognition site; other site
444177007094	dimerization interface [polypeptide binding]; other site
444177007095	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177007096	DNA binding site [nucleotide binding]
444177007097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177007098	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
444177007099	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177007100	dimer interface [polypeptide binding]; other site
444177007101	phosphorylation site [posttranslational modification]
444177007102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177007103	ATP binding site [chemical binding]; other site
444177007104	Mg2+ binding site [ion binding]; other site
444177007105	G-X-G motif; other site
444177007106	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
444177007107	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
444177007108	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
444177007109	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
444177007110	mercuric resistence transcriptional repressor protein MerD; Region: MerD; TIGR02054
444177007111	DNA binding residues [nucleotide binding]
444177007112	Tetratricopeptide repeat; Region: TPR_12; pfam13424
444177007113	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177007114	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177007115	metal binding site [ion binding]; metal-binding site
444177007116	active site
444177007117	I-site; other site
444177007118	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177007119	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177007120	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
444177007121	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177007122	salt bridge; other site
444177007123	non-specific DNA binding site [nucleotide binding]; other site
444177007124	sequence-specific DNA binding site [nucleotide binding]; other site
444177007125	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
444177007126	FtsX-like permease family; Region: FtsX; pfam02687
444177007127	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
444177007128	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
444177007129	FtsX-like permease family; Region: FtsX; pfam02687
444177007130	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
444177007131	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
444177007132	Walker A/P-loop; other site
444177007133	ATP binding site [chemical binding]; other site
444177007134	Q-loop/lid; other site
444177007135	ABC transporter signature motif; other site
444177007136	Walker B; other site
444177007137	D-loop; other site
444177007138	H-loop/switch region; other site
444177007139	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
444177007140	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177007141	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177007142	DNA binding residues [nucleotide binding]
444177007143	BioY family; Region: BioY; pfam02632
444177007144	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
444177007145	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
444177007146	active site
444177007147	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
444177007148	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
444177007149	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
444177007150	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
444177007151	putative active site [active]
444177007152	catalytic site [active]
444177007153	putative metal binding site [ion binding]; other site
444177007154	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177007155	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
444177007156	Isochorismatase family; Region: Isochorismatase; pfam00857
444177007157	catalytic triad [active]
444177007158	conserved cis-peptide bond; other site
444177007159	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
444177007160	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007161	Coenzyme A binding pocket [chemical binding]; other site
444177007162	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177007163	EamA-like transporter family; Region: EamA; pfam00892
444177007164	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
444177007165	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177007166	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007167	Coenzyme A binding pocket [chemical binding]; other site
444177007168	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177007169	fumarate hydratase; Reviewed; Region: fumC; PRK00485
444177007170	Class II fumarases; Region: Fumarase_classII; cd01362
444177007171	active site
444177007172	tetramer interface [polypeptide binding]; other site
444177007173	Predicted ATPase [General function prediction only]; Region: COG3910
444177007174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177007175	Walker A/P-loop; other site
444177007176	ATP binding site [chemical binding]; other site
444177007177	Q-loop/lid; other site
444177007178	ABC transporter signature motif; other site
444177007179	Walker B; other site
444177007180	D-loop; other site
444177007181	H-loop/switch region; other site
444177007182	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
444177007183	Sterol carrier protein domain; Region: SCP2_2; pfam13530
444177007184	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177007185	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177007186	H+ Antiporter protein; Region: 2A0121; TIGR00900
444177007187	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
444177007188	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177007189	DNA-binding site [nucleotide binding]; DNA binding site
444177007190	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177007191	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177007192	homodimer interface [polypeptide binding]; other site
444177007193	catalytic residue [active]
444177007194	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007195	Coenzyme A binding pocket [chemical binding]; other site
444177007196	Methyltransferase domain; Region: Methyltransf_31; pfam13847
444177007197	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177007198	S-adenosylmethionine binding site [chemical binding]; other site
444177007199	CAAX protease self-immunity; Region: Abi; pfam02517
444177007200	RNHCP domain; Region: RNHCP; pfam12647
444177007201	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
444177007202	hypothetical protein; Provisional; Region: PRK10621
444177007203	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
444177007204	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177007205	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177007206	putative substrate translocation pore; other site
444177007207	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177007208	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
444177007209	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177007210	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177007211	hypothetical protein; Provisional; Region: PRK03094
444177007212	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
444177007213	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
444177007214	metal binding site [ion binding]; metal-binding site
444177007215	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007216	Coenzyme A binding pocket [chemical binding]; other site
444177007217	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
444177007218	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
444177007219	nudix motif; other site
444177007220	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
444177007221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177007222	putative substrate translocation pore; other site
444177007223	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177007224	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007225	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177007226	Coenzyme A binding pocket [chemical binding]; other site
444177007227	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
444177007228	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
444177007229	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
444177007230	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
444177007231	DNA topoisomerase III; Provisional; Region: PRK07726
444177007232	active site
444177007233	putative metal-binding site [ion binding]; other site
444177007234	putative interdomain interaction site [polypeptide binding]; other site
444177007235	putative nucleotide binding site [chemical binding]; other site
444177007236	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
444177007237	domain I; other site
444177007238	DNA binding groove [nucleotide binding]
444177007239	phosphate binding site [ion binding]; other site
444177007240	domain II; other site
444177007241	domain III; other site
444177007242	nucleotide binding site [chemical binding]; other site
444177007243	catalytic site [active]
444177007244	domain IV; other site
444177007245	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
444177007246	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
444177007247	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177007248	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177007249	DNA binding residues [nucleotide binding]
444177007250	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
444177007251	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177007252	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
444177007253	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177007254	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
444177007255	NAD(P) binding site [chemical binding]; other site
444177007256	active site
444177007257	aspartate kinase; Reviewed; Region: PRK09034
444177007258	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
444177007259	putative catalytic residues [active]
444177007260	putative nucleotide binding site [chemical binding]; other site
444177007261	putative aspartate binding site [chemical binding]; other site
444177007262	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
444177007263	allosteric regulatory residue; other site
444177007264	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
444177007265	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
444177007266	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
444177007267	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
444177007268	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177007269	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177007270	homodimer interface [polypeptide binding]; other site
444177007271	catalytic residue [active]
444177007272	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
444177007273	catalytic core [active]
444177007274	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
444177007275	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
444177007276	cobalamin synthase; Reviewed; Region: cobS; PRK00235
444177007277	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
444177007278	catalytic core [active]
444177007279	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
444177007280	Transposase domain (DUF772); Region: DUF772; pfam05598
444177007281	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
444177007282	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
444177007283	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177007284	Walker A/P-loop; other site
444177007285	ATP binding site [chemical binding]; other site
444177007286	Q-loop/lid; other site
444177007287	ABC transporter signature motif; other site
444177007288	Walker B; other site
444177007289	D-loop; other site
444177007290	H-loop/switch region; other site
444177007291	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
444177007292	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
444177007293	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
444177007294	Walker A/P-loop; other site
444177007295	ATP binding site [chemical binding]; other site
444177007296	Q-loop/lid; other site
444177007297	ABC transporter signature motif; other site
444177007298	Walker B; other site
444177007299	D-loop; other site
444177007300	H-loop/switch region; other site
444177007301	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
444177007302	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
444177007303	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
444177007304	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177007305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177007306	active site
444177007307	phosphorylation site [posttranslational modification]
444177007308	intermolecular recognition site; other site
444177007309	dimerization interface [polypeptide binding]; other site
444177007310	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177007311	DNA binding site [nucleotide binding]
444177007312	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177007313	HAMP domain; Region: HAMP; pfam00672
444177007314	dimerization interface [polypeptide binding]; other site
444177007315	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177007316	phosphorylation site [posttranslational modification]
444177007317	dimer interface [polypeptide binding]; other site
444177007318	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177007319	ATP binding site [chemical binding]; other site
444177007320	Mg2+ binding site [ion binding]; other site
444177007321	G-X-G motif; other site
444177007322	EamA-like transporter family; Region: EamA; pfam00892
444177007323	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
444177007324	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177007325	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177007326	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
444177007327	dimerization interface [polypeptide binding]; other site
444177007328	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177007329	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177007330	putative substrate translocation pore; other site
444177007331	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
444177007332	putative hydrophobic ligand binding site [chemical binding]; other site
444177007333	Protein of unknown function (DUF1005); Region: DUF1005; pfam06219
444177007334	Esterase/lipase [General function prediction only]; Region: COG1647
444177007335	Protein of unknown function (DUF1271); Region: DUF1271; pfam06902
444177007336	Predicted acetyltransferase [General function prediction only]; Region: COG2388
444177007337	CHASE3 domain; Region: CHASE3; cl05000
444177007338	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177007339	dimerization interface [polypeptide binding]; other site
444177007340	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177007341	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177007342	dimer interface [polypeptide binding]; other site
444177007343	putative CheW interface [polypeptide binding]; other site
444177007344	Right handed beta helix region; Region: Beta_helix; pfam13229
444177007345	Right handed beta helix region; Region: Beta_helix; pfam13229
444177007346	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177007347	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007348	Coenzyme A binding pocket [chemical binding]; other site
444177007349	Methyltransferase domain; Region: Methyltransf_31; pfam13847
444177007350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177007351	S-adenosylmethionine binding site [chemical binding]; other site
444177007352	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
444177007353	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
444177007354	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
444177007355	NADH(P)-binding; Region: NAD_binding_10; pfam13460
444177007356	NAD binding site [chemical binding]; other site
444177007357	substrate binding site [chemical binding]; other site
444177007358	putative active site [active]
444177007359	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
444177007360	Isochorismatase family; Region: Isochorismatase; pfam00857
444177007361	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
444177007362	catalytic triad [active]
444177007363	conserved cis-peptide bond; other site
444177007364	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177007365	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177007366	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
444177007367	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
444177007368	dimer interface [polypeptide binding]; other site
444177007369	putative tRNA-binding site [nucleotide binding]; other site
444177007370	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
444177007371	Helix-turn-helix domain; Region: HTH_36; pfam13730
444177007372	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
444177007373	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
444177007374	Phosphotransferase enzyme family; Region: APH; pfam01636
444177007375	active site
444177007376	ATP binding site [chemical binding]; other site
444177007377	substrate binding site [chemical binding]; other site
444177007378	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
444177007379	G2 box; other site
444177007380	Switch I region; other site
444177007381	Switch II region; other site
444177007382	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
444177007383	amidase catalytic site [active]
444177007384	Zn binding residues [ion binding]; other site
444177007385	substrate binding site [chemical binding]; other site
444177007386	S-layer homology domain; Region: SLH; pfam00395
444177007387	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177007388	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
444177007389	A new structural DNA glycosylase; Region: AlkD_like; cd06561
444177007390	active site
444177007391	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
444177007392	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
444177007393	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177007394	catalytic residue [active]
444177007395	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
444177007396	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
444177007397	classical (c) SDRs; Region: SDR_c; cd05233
444177007398	NAD(P) binding site [chemical binding]; other site
444177007399	active site
444177007400	DinB family; Region: DinB; cl17821
444177007401	EamA-like transporter family; Region: EamA; pfam00892
444177007402	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
444177007403	Sodium Bile acid symporter family; Region: SBF; cl17470
444177007404	HEAT repeats; Region: HEAT_2; pfam13646
444177007405	myosin-cross-reactive antigen; Provisional; Region: PRK13977
444177007406	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007407	Coenzyme A binding pocket [chemical binding]; other site
444177007408	conserved hypothetical protein; Region: TIGR02328
444177007409	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
444177007410	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
444177007411	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177007412	active site
444177007413	motif I; other site
444177007414	motif II; other site
444177007415	DinB family; Region: DinB; cl17821
444177007416	DinB superfamily; Region: DinB_2; pfam12867
444177007417	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
444177007418	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
444177007419	FOG: PKD repeat [General function prediction only]; Region: COG3291
444177007420	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
444177007421	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
444177007422	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177007423	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
444177007424	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
444177007425	DNA-binding site [nucleotide binding]; DNA binding site
444177007426	RNA-binding motif; other site
444177007427	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
444177007428	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
444177007429	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
444177007430	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
444177007431	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
444177007432	catalytic core [active]
444177007433	hypothetical protein; Provisional; Region: PRK06771
444177007434	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
444177007435	HTH-like domain; Region: HTH_21; pfam13276
444177007436	Integrase core domain; Region: rve; pfam00665
444177007437	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007438	Coenzyme A binding pocket [chemical binding]; other site
444177007439	Transcriptional regulators [Transcription]; Region: MarR; COG1846
444177007440	MarR family; Region: MarR_2; pfam12802
444177007441	MarR family; Region: MarR_2; cl17246
444177007442	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177007443	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177007444	putative substrate translocation pore; other site
444177007445	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177007446	MarR family; Region: MarR; pfam01047
444177007447	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
444177007448	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177007449	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177007450	DNA binding residues [nucleotide binding]
444177007451	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
444177007452	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
444177007453	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
444177007454	ligand binding site [chemical binding]; other site
444177007455	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
444177007456	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
444177007457	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177007458	active site
444177007459	motif I; other site
444177007460	motif II; other site
444177007461	Transcriptional regulator; Region: Rrf2; cl17282
444177007462	Uncharacterized conserved protein [Function unknown]; Region: COG1683
444177007463	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177007464	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177007465	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
444177007466	EamA-like transporter family; Region: EamA; pfam00892
444177007467	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
444177007468	EamA-like transporter family; Region: EamA; pfam00892
444177007469	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177007470	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177007471	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
444177007472	dimerization interface [polypeptide binding]; other site
444177007473	LysR substrate binding domain; Region: LysR_substrate; pfam03466
444177007474	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177007475	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
444177007476	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
444177007477	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
444177007478	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
444177007479	Predicted membrane protein [Function unknown]; Region: COG2323
444177007480	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
444177007481	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177007482	Zn2+ binding site [ion binding]; other site
444177007483	Mg2+ binding site [ion binding]; other site
444177007484	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177007485	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177007486	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
444177007487	Spore germination protein; Region: Spore_permease; cl17796
444177007488	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177007489	Spore germination protein; Region: Spore_permease; cl17796
444177007490	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177007491	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177007492	serine-protein kinase RsbW; Provisional; Region: PRK04069
444177007493	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
444177007494	ATP binding site [chemical binding]; other site
444177007495	Mg2+ binding site [ion binding]; other site
444177007496	G-X-G motif; other site
444177007497	Predicted membrane protein [Function unknown]; Region: COG2323
444177007498	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
444177007499	putative active site [active]
444177007500	nucleotide binding site [chemical binding]; other site
444177007501	nudix motif; other site
444177007502	putative metal binding site [ion binding]; other site
444177007503	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
444177007504	nudix motif; other site
444177007505	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
444177007506	Resolvase, N terminal domain; Region: Resolvase; pfam00239
444177007507	catalytic residues [active]
444177007508	catalytic nucleophile [active]
444177007509	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
444177007510	DNA-binding interface [nucleotide binding]; DNA binding site
444177007511	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
444177007512	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
444177007513	Sulfate transporter family; Region: Sulfate_transp; pfam00916
444177007514	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
444177007515	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
444177007516	Ligand Binding Site [chemical binding]; other site
444177007517	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
444177007518	Ligand Binding Site [chemical binding]; other site
444177007519	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
444177007520	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
444177007521	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177007522	dimerization interface [polypeptide binding]; other site
444177007523	putative DNA binding site [nucleotide binding]; other site
444177007524	putative Zn2+ binding site [ion binding]; other site
444177007525	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
444177007526	arsenical-resistance protein; Region: acr3; TIGR00832
444177007527	Low molecular weight phosphatase family; Region: LMWPc; cd00115
444177007528	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
444177007529	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
444177007530	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
444177007531	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
444177007532	P loop; other site
444177007533	Nucleotide binding site [chemical binding]; other site
444177007534	DTAP/Switch II; other site
444177007535	Switch I; other site
444177007536	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
444177007537	P loop; other site
444177007538	Nucleotide binding site [chemical binding]; other site
444177007539	DTAP/Switch II; other site
444177007540	Switch I; other site
444177007541	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177007542	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177007543	Protein of unknown function (DUF421); Region: DUF421; cl00990
444177007544	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
444177007545	CotJB protein; Region: CotJB; pfam12652
444177007546	CotJB protein; Region: CotJB; pfam12652
444177007547	YpjP-like protein; Region: YpjP; pfam14005
444177007548	HAMP domain; Region: HAMP; pfam00672
444177007549	dimerization interface [polypeptide binding]; other site
444177007550	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177007551	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177007552	dimer interface [polypeptide binding]; other site
444177007553	putative CheW interface [polypeptide binding]; other site
444177007554	Predicted transcriptional regulators [Transcription]; Region: COG1733
444177007555	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
444177007556	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
444177007557	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
444177007558	putative NAD(P) binding site [chemical binding]; other site
444177007559	dimer interface [polypeptide binding]; other site
444177007560	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
444177007561	active site
444177007562	substrate binding site [chemical binding]; other site
444177007563	ATP binding site [chemical binding]; other site
444177007564	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
444177007565	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
444177007566	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
444177007567	Beta-lactamase; Region: Beta-lactamase; pfam00144
444177007568	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
444177007569	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
444177007570	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
444177007571	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
444177007572	active site residue [active]
444177007573	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
444177007574	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
444177007575	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
444177007576	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
444177007577	putative dimer interface [polypeptide binding]; other site
444177007578	catalytic triad [active]
444177007579	Leucine rich repeat; Region: LRR_8; pfam13855
444177007580	Leucine rich repeat; Region: LRR_8; pfam13855
444177007581	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
444177007582	Leucine rich repeat; Region: LRR_8; pfam13855
444177007583	Substrate binding site [chemical binding]; other site
444177007584	Leucine rich repeat; Region: LRR_8; pfam13855
444177007585	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
444177007586	Methyltransferase domain; Region: Methyltransf_31; pfam13847
444177007587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177007588	S-adenosylmethionine binding site [chemical binding]; other site
444177007589	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
444177007590	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177007591	Zn2+ binding site [ion binding]; other site
444177007592	Mg2+ binding site [ion binding]; other site
444177007593	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177007594	putative DNA binding site [nucleotide binding]; other site
444177007595	putative Zn2+ binding site [ion binding]; other site
444177007596	hypothetical protein; Provisional; Region: PRK09272
444177007597	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007598	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
444177007599	Coenzyme A binding pocket [chemical binding]; other site
444177007600	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
444177007601	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
444177007602	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
444177007603	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
444177007604	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
444177007605	active site
444177007606	dimer interface [polypeptide binding]; other site
444177007607	motif 1; other site
444177007608	motif 2; other site
444177007609	motif 3; other site
444177007610	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
444177007611	anticodon binding site; other site
444177007612	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
444177007613	catalytic core [active]
444177007614	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177007615	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177007616	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
444177007617	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177007618	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177007619	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
444177007620	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007621	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177007622	Coenzyme A binding pocket [chemical binding]; other site
444177007623	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
444177007624	Methyltransferase domain; Region: Methyltransf_23; pfam13489
444177007625	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177007626	S-adenosylmethionine binding site [chemical binding]; other site
444177007627	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
444177007628	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
444177007629	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
444177007630	DNA-binding site [nucleotide binding]; DNA binding site
444177007631	RNA-binding motif; other site
444177007632	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177007633	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177007634	active site
444177007635	phosphorylation site [posttranslational modification]
444177007636	intermolecular recognition site; other site
444177007637	dimerization interface [polypeptide binding]; other site
444177007638	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
444177007639	DNA binding residues [nucleotide binding]
444177007640	dimerization interface [polypeptide binding]; other site
444177007641	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
444177007642	Histidine kinase; Region: HisKA_3; pfam07730
444177007643	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177007644	ATP binding site [chemical binding]; other site
444177007645	Mg2+ binding site [ion binding]; other site
444177007646	G-X-G motif; other site
444177007647	thymidylate synthase; Region: thym_sym; TIGR03284
444177007648	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
444177007649	dimerization interface [polypeptide binding]; other site
444177007650	active site
444177007651	Transcriptional regulator; Region: Rrf2; pfam02082
444177007652	Rrf2 family protein; Region: rrf2_super; TIGR00738
444177007653	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
444177007654	NADH(P)-binding; Region: NAD_binding_10; pfam13460
444177007655	NAD binding site [chemical binding]; other site
444177007656	substrate binding site [chemical binding]; other site
444177007657	putative active site [active]
444177007658	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
444177007659	Aspartase; Region: Aspartase; cd01357
444177007660	active sites [active]
444177007661	tetramer interface [polypeptide binding]; other site
444177007662	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177007663	dimerization interface [polypeptide binding]; other site
444177007664	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177007665	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177007666	dimer interface [polypeptide binding]; other site
444177007667	putative CheW interface [polypeptide binding]; other site
444177007668	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
444177007669	alpha-gamma subunit interface [polypeptide binding]; other site
444177007670	beta-gamma subunit interface [polypeptide binding]; other site
444177007671	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
444177007672	gamma-beta subunit interface [polypeptide binding]; other site
444177007673	alpha-beta subunit interface [polypeptide binding]; other site
444177007674	urease subunit alpha; Reviewed; Region: ureC; PRK13207
444177007675	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
444177007676	subunit interactions [polypeptide binding]; other site
444177007677	active site
444177007678	flap region; other site
444177007679	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
444177007680	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
444177007681	dimer interface [polypeptide binding]; other site
444177007682	catalytic residues [active]
444177007683	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
444177007684	UreF; Region: UreF; pfam01730
444177007685	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
444177007686	UreD urease accessory protein; Region: UreD; pfam01774
444177007687	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
444177007688	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
444177007689	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177007690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177007691	conserved gate region; other site
444177007692	putative PBP binding loops; other site
444177007693	ABC-ATPase subunit interface; other site
444177007694	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
444177007695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177007696	dimer interface [polypeptide binding]; other site
444177007697	conserved gate region; other site
444177007698	putative PBP binding loops; other site
444177007699	ABC-ATPase subunit interface; other site
444177007700	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
444177007701	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177007702	Walker A/P-loop; other site
444177007703	ATP binding site [chemical binding]; other site
444177007704	Q-loop/lid; other site
444177007705	ABC transporter signature motif; other site
444177007706	Walker B; other site
444177007707	D-loop; other site
444177007708	H-loop/switch region; other site
444177007709	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
444177007710	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
444177007711	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177007712	Walker A/P-loop; other site
444177007713	ATP binding site [chemical binding]; other site
444177007714	Q-loop/lid; other site
444177007715	ABC transporter signature motif; other site
444177007716	Walker B; other site
444177007717	D-loop; other site
444177007718	H-loop/switch region; other site
444177007719	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
444177007720	pentamer interface [polypeptide binding]; other site
444177007721	dodecaamer interface [polypeptide binding]; other site
444177007722	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
444177007723	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
444177007724	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
444177007725	G1 box; other site
444177007726	putative GEF interaction site [polypeptide binding]; other site
444177007727	GTP/Mg2+ binding site [chemical binding]; other site
444177007728	Switch I region; other site
444177007729	G2 box; other site
444177007730	G3 box; other site
444177007731	Switch II region; other site
444177007732	G4 box; other site
444177007733	G5 box; other site
444177007734	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
444177007735	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
444177007736	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
444177007737	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
444177007738	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
444177007739	putative ligand binding residues [chemical binding]; other site
444177007740	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
444177007741	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
444177007742	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
444177007743	putative RNA binding site [nucleotide binding]; other site
444177007744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177007745	S-adenosylmethionine binding site [chemical binding]; other site
444177007746	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
444177007747	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
444177007748	substrate binding pocket [chemical binding]; other site
444177007749	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
444177007750	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
444177007751	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
444177007752	folate binding site [chemical binding]; other site
444177007753	NADP+ binding site [chemical binding]; other site
444177007754	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
444177007755	nucleotide binding site/active site [active]
444177007756	HIT family signature motif; other site
444177007757	catalytic residue [active]
444177007758	Transposase domain (DUF772); Region: DUF772; pfam05598
444177007759	Haemolysin-III related; Region: HlyIII; cl03831
444177007760	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
444177007761	EDD domain protein, DegV family; Region: DegV; TIGR00762
444177007762	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
444177007763	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
444177007764	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
444177007765	active site
444177007766	catalytic triad [active]
444177007767	oxyanion hole [active]
444177007768	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
444177007769	methionine sulfoxide reductase A; Provisional; Region: PRK14054
444177007770	methionine sulfoxide reductase B; Provisional; Region: PRK00222
444177007771	SelR domain; Region: SelR; pfam01641
444177007772	CHASE3 domain; Region: CHASE3; cl05000
444177007773	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
444177007774	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
444177007775	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177007776	dimer interface [polypeptide binding]; other site
444177007777	putative CheW interface [polypeptide binding]; other site
444177007778	hypothetical protein; Provisional; Region: PRK13672
444177007779	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
444177007780	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
444177007781	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
444177007782	S-layer homology domain; Region: SLH; pfam00395
444177007783	S-layer homology domain; Region: SLH; pfam00395
444177007784	S-layer homology domain; Region: SLH; pfam00395
444177007785	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007786	Coenzyme A binding pocket [chemical binding]; other site
444177007787	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177007788	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
444177007789	Coenzyme A binding pocket [chemical binding]; other site
444177007790	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177007791	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
444177007792	Beta-lactamase; Region: Beta-lactamase; pfam00144
444177007793	AAA domain; Region: AAA_18; pfam13238
444177007794	AAA domain; Region: AAA_17; pfam13207
444177007795	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177007796	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177007797	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
444177007798	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
444177007799	methionine sulfoxide reductase A; Provisional; Region: PRK05528
444177007800	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
444177007801	nudix motif; other site
444177007802	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
444177007803	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177007804	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177007805	dimer interface [polypeptide binding]; other site
444177007806	phosphorylation site [posttranslational modification]
444177007807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177007808	ATP binding site [chemical binding]; other site
444177007809	Mg2+ binding site [ion binding]; other site
444177007810	G-X-G motif; other site
444177007811	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
444177007812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177007813	active site
444177007814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177007815	phosphorylation site [posttranslational modification]
444177007816	intermolecular recognition site; other site
444177007817	dimerization interface [polypeptide binding]; other site
444177007818	Histidine kinase; Region: His_kinase; pfam06580
444177007819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177007820	ATP binding site [chemical binding]; other site
444177007821	Mg2+ binding site [ion binding]; other site
444177007822	G-X-G motif; other site
444177007823	EamA-like transporter family; Region: EamA; pfam00892
444177007824	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
444177007825	EamA-like transporter family; Region: EamA; pfam00892
444177007826	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
444177007827	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177007828	putative DNA binding site [nucleotide binding]; other site
444177007829	putative Zn2+ binding site [ion binding]; other site
444177007830	AsnC family; Region: AsnC_trans_reg; pfam01037
444177007831	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177007832	dimerization interface [polypeptide binding]; other site
444177007833	putative DNA binding site [nucleotide binding]; other site
444177007834	putative Zn2+ binding site [ion binding]; other site
444177007835	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
444177007836	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177007837	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177007838	DinB superfamily; Region: DinB_2; pfam12867
444177007839	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
444177007840	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
444177007841	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
444177007842	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
444177007843	NodB motif; other site
444177007844	active site
444177007845	catalytic site [active]
444177007846	metal binding site [ion binding]; metal-binding site
444177007847	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
444177007848	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
444177007849	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177007850	Spore germination protein; Region: Spore_permease; cl17796
444177007851	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177007852	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177007853	multidrug efflux protein; Reviewed; Region: PRK01766
444177007854	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
444177007855	cation binding site [ion binding]; other site
444177007856	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
444177007857	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
444177007858	active site
444177007859	homodimer interface [polypeptide binding]; other site
444177007860	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177007861	PAS fold; Region: PAS_4; pfam08448
444177007862	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177007863	putative active site [active]
444177007864	heme pocket [chemical binding]; other site
444177007865	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177007866	PAS domain; Region: PAS_9; pfam13426
444177007867	putative active site [active]
444177007868	heme pocket [chemical binding]; other site
444177007869	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177007870	PAS domain; Region: PAS_9; pfam13426
444177007871	putative active site [active]
444177007872	heme pocket [chemical binding]; other site
444177007873	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177007874	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177007875	metal binding site [ion binding]; metal-binding site
444177007876	active site
444177007877	I-site; other site
444177007878	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177007879	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177007880	active site
444177007881	phosphorylation site [posttranslational modification]
444177007882	intermolecular recognition site; other site
444177007883	dimerization interface [polypeptide binding]; other site
444177007884	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177007885	DNA binding site [nucleotide binding]
444177007886	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177007887	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177007888	dimerization interface [polypeptide binding]; other site
444177007889	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177007890	dimer interface [polypeptide binding]; other site
444177007891	phosphorylation site [posttranslational modification]
444177007892	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177007893	ATP binding site [chemical binding]; other site
444177007894	Mg2+ binding site [ion binding]; other site
444177007895	G-X-G motif; other site
444177007896	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
444177007897	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
444177007898	TPP-binding site [chemical binding]; other site
444177007899	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
444177007900	dimer interface [polypeptide binding]; other site
444177007901	PYR/PP interface [polypeptide binding]; other site
444177007902	TPP binding site [chemical binding]; other site
444177007903	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
444177007904	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
444177007905	E3 interaction surface; other site
444177007906	lipoyl attachment site [posttranslational modification]; other site
444177007907	e3 binding domain; Region: E3_binding; pfam02817
444177007908	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
444177007909	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
444177007910	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
444177007911	substrate binding pocket [chemical binding]; other site
444177007912	membrane-bound complex binding site; other site
444177007913	hinge residues; other site
444177007914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177007915	dimer interface [polypeptide binding]; other site
444177007916	conserved gate region; other site
444177007917	putative PBP binding loops; other site
444177007918	ABC-ATPase subunit interface; other site
444177007919	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
444177007920	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
444177007921	Walker A/P-loop; other site
444177007922	ATP binding site [chemical binding]; other site
444177007923	Q-loop/lid; other site
444177007924	ABC transporter signature motif; other site
444177007925	Walker B; other site
444177007926	D-loop; other site
444177007927	H-loop/switch region; other site
444177007928	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
444177007929	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112
444177007930	Acylphosphatase; Region: Acylphosphatase; pfam00708
444177007931	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177007932	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177007933	dimer interface [polypeptide binding]; other site
444177007934	putative CheW interface [polypeptide binding]; other site
444177007935	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
444177007936	Protein of unknown function (DUF1033); Region: DUF1033; cl11549
444177007937	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
444177007938	DNA-binding site [nucleotide binding]; DNA binding site
444177007939	RNA-binding motif; other site
444177007940	Uncharacterized conserved protein [Function unknown]; Region: COG3339
444177007941	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
444177007942	DinB family; Region: DinB; cl17821
444177007943	DinB superfamily; Region: DinB_2; pfam12867
444177007944	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177007945	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177007946	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
444177007947	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
444177007948	dimer interface [polypeptide binding]; other site
444177007949	active site
444177007950	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
444177007951	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
444177007952	active site
444177007953	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
444177007954	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177007955	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177007956	ABC transporter; Region: ABC_tran_2; pfam12848
444177007957	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177007958	RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642
444177007959	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177007960	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177007961	DNA binding residues [nucleotide binding]
444177007962	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
444177007963	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
444177007964	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
444177007965	LytTr DNA-binding domain; Region: LytTR; smart00850
444177007966	CAAX protease self-immunity; Region: Abi; pfam02517
444177007967	Predicted transcriptional regulator [Transcription]; Region: COG2378
444177007968	HTH domain; Region: HTH_11; pfam08279
444177007969	WYL domain; Region: WYL; pfam13280
444177007970	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
444177007971	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
444177007972	conserved cys residue [active]
444177007973	HTH-like domain; Region: HTH_21; pfam13276
444177007974	Integrase core domain; Region: rve; pfam00665
444177007975	Integrase core domain; Region: rve_2; pfam13333
444177007976	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177007977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177007978	active site
444177007979	phosphorylation site [posttranslational modification]
444177007980	intermolecular recognition site; other site
444177007981	dimerization interface [polypeptide binding]; other site
444177007982	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177007983	DNA binding site [nucleotide binding]
444177007984	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
444177007985	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
444177007986	Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318
444177007987	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
444177007988	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
444177007989	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177007990	non-specific DNA binding site [nucleotide binding]; other site
444177007991	salt bridge; other site
444177007992	sequence-specific DNA binding site [nucleotide binding]; other site
444177007993	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
444177007994	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
444177007995	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
444177007996	glycosyltransferase, MGT family; Region: MGT; TIGR01426
444177007997	active site
444177007998	TDP-binding site; other site
444177007999	acceptor substrate-binding pocket; other site
444177008000	homodimer interface [polypeptide binding]; other site
444177008001	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
444177008002	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
444177008003	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
444177008004	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
444177008005	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177008006	Coenzyme A binding pocket [chemical binding]; other site
444177008007	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177008008	PAS fold; Region: PAS_3; pfam08447
444177008009	putative active site [active]
444177008010	heme pocket [chemical binding]; other site
444177008011	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177008012	PAS fold; Region: PAS_3; pfam08447
444177008013	putative active site [active]
444177008014	heme pocket [chemical binding]; other site
444177008015	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177008016	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177008017	dimer interface [polypeptide binding]; other site
444177008018	putative CheW interface [polypeptide binding]; other site
444177008019	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177008020	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
444177008021	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
444177008022	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
444177008023	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
444177008024	active site
444177008025	HIGH motif; other site
444177008026	KMSK motif region; other site
444177008027	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
444177008028	tRNA binding surface [nucleotide binding]; other site
444177008029	anticodon binding site; other site
444177008030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177008031	putative substrate translocation pore; other site
444177008032	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
444177008033	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
444177008034	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
444177008035	ATP binding site [chemical binding]; other site
444177008036	putative Mg++ binding site [ion binding]; other site
444177008037	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177008038	nucleotide binding region [chemical binding]; other site
444177008039	ATP-binding site [chemical binding]; other site
444177008040	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
444177008041	HRDC domain; Region: HRDC; pfam00570
444177008042	methionine sulfoxide reductase A; Provisional; Region: PRK14054
444177008043	Transcriptional regulator [Transcription]; Region: LytR; COG1316
444177008044	Domain of unknown function DUF20; Region: UPF0118; pfam01594
444177008045	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
444177008046	aspartate aminotransferase; Provisional; Region: PRK07681
444177008047	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177008048	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177008049	homodimer interface [polypeptide binding]; other site
444177008050	catalytic residue [active]
444177008051	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
444177008052	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
444177008053	active site
444177008054	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
444177008055	enoyl-CoA hydratase; Provisional; Region: PRK06144
444177008056	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
444177008057	substrate binding site [chemical binding]; other site
444177008058	oxyanion hole (OAH) forming residues; other site
444177008059	trimer interface [polypeptide binding]; other site
444177008060	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
444177008061	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
444177008062	catalytic residues [active]
444177008063	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
444177008064	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
444177008065	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
444177008066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
444177008067	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
444177008068	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
444177008069	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177008070	active site
444177008071	DNA binding site [nucleotide binding]
444177008072	Int/Topo IB signature motif; other site
444177008073	DinB family; Region: DinB; cl17821
444177008074	DinB superfamily; Region: DinB_2; pfam12867
444177008075	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177008076	PAS domain; Region: PAS_9; pfam13426
444177008077	putative active site [active]
444177008078	heme pocket [chemical binding]; other site
444177008079	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177008080	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177008081	metal binding site [ion binding]; metal-binding site
444177008082	active site
444177008083	I-site; other site
444177008084	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
444177008085	prolyl-tRNA synthetase; Provisional; Region: PRK08661
444177008086	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
444177008087	dimer interface [polypeptide binding]; other site
444177008088	motif 1; other site
444177008089	active site
444177008090	motif 2; other site
444177008091	motif 3; other site
444177008092	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
444177008093	anticodon binding site; other site
444177008094	zinc-binding site [ion binding]; other site
444177008095	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
444177008096	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
444177008097	Probable transposase; Region: OrfB_IS605; pfam01385
444177008098	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
444177008099	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
444177008100	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
444177008101	DNA binding residues [nucleotide binding]
444177008102	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
444177008103	catalytic residues [active]
444177008104	catalytic nucleophile [active]
444177008105	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
444177008106	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
444177008107	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
444177008108	nudix motif; other site
444177008109	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
444177008110	Ligand Binding Site [chemical binding]; other site
444177008111	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177008112	putative DNA binding site [nucleotide binding]; other site
444177008113	putative Zn2+ binding site [ion binding]; other site
444177008114	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
444177008115	putative hydrophobic ligand binding site [chemical binding]; other site
444177008116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177008117	Walker A/P-loop; other site
444177008118	ATP binding site [chemical binding]; other site
444177008119	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
444177008120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177008121	ABC transporter signature motif; other site
444177008122	Walker B; other site
444177008123	D-loop; other site
444177008124	H-loop/switch region; other site
444177008125	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
444177008126	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177008127	Walker A/P-loop; other site
444177008128	ATP binding site [chemical binding]; other site
444177008129	Q-loop/lid; other site
444177008130	ABC transporter signature motif; other site
444177008131	Walker B; other site
444177008132	D-loop; other site
444177008133	H-loop/switch region; other site
444177008134	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
444177008135	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
444177008136	active site
444177008137	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177008138	Spore germination protein; Region: Spore_permease; pfam03845
444177008139	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177008140	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
444177008141	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177008142	Coenzyme A binding pocket [chemical binding]; other site
444177008143	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
444177008144	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177008145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177008146	active site
444177008147	phosphorylation site [posttranslational modification]
444177008148	intermolecular recognition site; other site
444177008149	dimerization interface [polypeptide binding]; other site
444177008150	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177008151	DNA binding site [nucleotide binding]
444177008152	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177008153	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177008154	dimerization interface [polypeptide binding]; other site
444177008155	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177008156	dimer interface [polypeptide binding]; other site
444177008157	phosphorylation site [posttranslational modification]
444177008158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177008159	ATP binding site [chemical binding]; other site
444177008160	Mg2+ binding site [ion binding]; other site
444177008161	G-X-G motif; other site
444177008162	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
444177008163	cyanate transporter; Region: CynX; TIGR00896
444177008164	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
444177008165	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
444177008166	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177008167	non-specific DNA binding site [nucleotide binding]; other site
444177008168	salt bridge; other site
444177008169	sequence-specific DNA binding site [nucleotide binding]; other site
444177008170	Cupin domain; Region: Cupin_2; pfam07883
444177008171	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
444177008172	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
444177008173	Subunit I/III interface [polypeptide binding]; other site
444177008174	Subunit III/IV interface [polypeptide binding]; other site
444177008175	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
444177008176	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
444177008177	D-pathway; other site
444177008178	Putative ubiquinol binding site [chemical binding]; other site
444177008179	Low-spin heme (heme b) binding site [chemical binding]; other site
444177008180	Putative water exit pathway; other site
444177008181	Binuclear center (heme o3/CuB) [ion binding]; other site
444177008182	K-pathway; other site
444177008183	Putative proton exit pathway; other site
444177008184	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
444177008185	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
444177008186	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177008187	DNA-binding site [nucleotide binding]; DNA binding site
444177008188	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177008189	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177008190	homodimer interface [polypeptide binding]; other site
444177008191	catalytic residue [active]
444177008192	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177008193	H-loop/switch region; other site
444177008194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177008195	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
444177008196	putative substrate translocation pore; other site
444177008197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177008198	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
444177008199	NlpC/P60 family; Region: NLPC_P60; pfam00877
444177008200	S-layer homology domain; Region: SLH; pfam00395
444177008201	S-layer homology domain; Region: SLH; pfam00395
444177008202	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
444177008203	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161
444177008204	putative ligand binding site [chemical binding]; other site
444177008205	putative NAD binding site [chemical binding]; other site
444177008206	catalytic site [active]
444177008207	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
444177008208	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177008209	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177008210	putative substrate translocation pore; other site
444177008211	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
444177008212	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
444177008213	L-lactate permease; Region: Lactate_perm; cl00701
444177008214	allantoate amidohydrolase; Region: AllC; TIGR03176
444177008215	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
444177008216	active site
444177008217	metal binding site [ion binding]; metal-binding site
444177008218	dimer interface [polypeptide binding]; other site
444177008219	putative allantoin catabolism protein; Region: ura-cupin; TIGR03214
444177008220	Cupin domain; Region: Cupin_2; pfam07883
444177008221	ureidoglycolate dehydrogenase; Provisional; Region: PRK15025
444177008222	membrane protein FdrA; Validated; Region: PRK06091
444177008223	CoA binding domain; Region: CoA_binding; pfam02629
444177008224	CoA-ligase; Region: Ligase_CoA; pfam00549
444177008225	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
444177008226	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
444177008227	carbamate kinase; Reviewed; Region: PRK12686
444177008228	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
444177008229	putative substrate binding site [chemical binding]; other site
444177008230	nucleotide binding site [chemical binding]; other site
444177008231	nucleotide binding site [chemical binding]; other site
444177008232	homodimer interface [polypeptide binding]; other site
444177008233	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
444177008234	dimer interface [polypeptide binding]; other site
444177008235	FMN binding site [chemical binding]; other site
444177008236	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
444177008237	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177008238	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177008239	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177008240	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177008241	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
444177008242	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
444177008243	putative NAD(P) binding site [chemical binding]; other site
444177008244	active site
444177008245	putative substrate binding site [chemical binding]; other site
444177008246	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
444177008247	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
444177008248	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
444177008249	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177008250	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177008251	intersubunit interface [polypeptide binding]; other site
444177008252	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177008253	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177008254	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177008255	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177008256	intersubunit interface [polypeptide binding]; other site
444177008257	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
444177008258	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
444177008259	putative FMN binding site [chemical binding]; other site
444177008260	Predicted transcriptional regulators [Transcription]; Region: COG1733
444177008261	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
444177008262	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
444177008263	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
444177008264	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177008265	short chain dehydrogenase; Provisional; Region: PRK07041
444177008266	NAD(P) binding site [chemical binding]; other site
444177008267	active site
444177008268	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
444177008269	DNA binding site [nucleotide binding]
444177008270	Int/Topo IB signature motif; other site
444177008271	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
444177008272	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
444177008273	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
444177008274	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
444177008275	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
444177008276	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177008277	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177008278	dimerization interface [polypeptide binding]; other site
444177008279	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177008280	dimer interface [polypeptide binding]; other site
444177008281	phosphorylation site [posttranslational modification]
444177008282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177008283	ATP binding site [chemical binding]; other site
444177008284	Mg2+ binding site [ion binding]; other site
444177008285	G-X-G motif; other site
444177008286	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177008287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177008288	active site
444177008289	phosphorylation site [posttranslational modification]
444177008290	intermolecular recognition site; other site
444177008291	dimerization interface [polypeptide binding]; other site
444177008292	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177008293	DNA binding site [nucleotide binding]
444177008294	Radical SAM superfamily; Region: Radical_SAM; pfam04055
444177008295	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177008296	FeS/SAM binding site; other site
444177008297	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
444177008298	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
444177008299	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
444177008300	DNA binding site [nucleotide binding]
444177008301	active site
444177008302	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
444177008303	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
444177008304	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177008305	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177008306	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
444177008307	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
444177008308	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
444177008309	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
444177008310	minor groove reading motif; other site
444177008311	helix-hairpin-helix signature motif; other site
444177008312	substrate binding pocket [chemical binding]; other site
444177008313	active site
444177008314	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
444177008315	catalytic triad [active]
444177008316	active site nucleophile [active]
444177008317	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
444177008318	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
444177008319	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177008320	ATP binding site [chemical binding]; other site
444177008321	Walker B motif; other site
444177008322	arginine finger; other site
444177008323	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177008324	Tetratricopeptide repeat; Region: TPR_16; pfam13432
444177008325	binding surface
444177008326	TPR motif; other site
444177008327	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177008328	binding surface
444177008329	TPR motif; other site
444177008330	TPR repeat; Region: TPR_11; pfam13414
444177008331	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177008332	binding surface
444177008333	TPR motif; other site
444177008334	TPR repeat; Region: TPR_11; pfam13414
444177008335	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
444177008336	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
444177008337	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177008338	Walker A/P-loop; other site
444177008339	ATP binding site [chemical binding]; other site
444177008340	Q-loop/lid; other site
444177008341	ABC transporter signature motif; other site
444177008342	Walker B; other site
444177008343	D-loop; other site
444177008344	H-loop/switch region; other site
444177008345	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
444177008346	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
444177008347	classical (c) SDRs; Region: SDR_c; cd05233
444177008348	NAD(P) binding site [chemical binding]; other site
444177008349	active site
444177008350	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
444177008351	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
444177008352	dimerization interface [polypeptide binding]; other site
444177008353	domain crossover interface; other site
444177008354	redox-dependent activation switch; other site
444177008355	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177008356	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
444177008357	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
444177008358	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
444177008359	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
444177008360	catalytic loop [active]
444177008361	iron binding site [ion binding]; other site
444177008362	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177008363	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
444177008364	Sodium Bile acid symporter family; Region: SBF; cl17470
444177008365	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
444177008366	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177008367	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177008368	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
444177008369	acyl carrier protein; Provisional; Region: PRK07639
444177008370	acyl-CoA synthetase; Validated; Region: PRK08308
444177008371	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
444177008372	AMP binding site [chemical binding]; other site
444177008373	active site
444177008374	acyl-activating enzyme (AAE) consensus motif; other site
444177008375	CoA binding site [chemical binding]; other site
444177008376	IucA / IucC family; Region: IucA_IucC; pfam04183
444177008377	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
444177008378	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
444177008379	IucA / IucC family; Region: IucA_IucC; pfam04183
444177008380	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
444177008381	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
444177008382	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177008383	Coenzyme A binding pocket [chemical binding]; other site
444177008384	Predicted membrane protein [Function unknown]; Region: COG2364
444177008385	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
444177008386	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
444177008387	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
444177008388	substrate binding site [chemical binding]; other site
444177008389	oxyanion hole (OAH) forming residues; other site
444177008390	trimer interface [polypeptide binding]; other site
444177008391	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
444177008392	enoyl-CoA hydratase; Provisional; Region: PRK07658
444177008393	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
444177008394	substrate binding site [chemical binding]; other site
444177008395	oxyanion hole (OAH) forming residues; other site
444177008396	trimer interface [polypeptide binding]; other site
444177008397	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
444177008398	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
444177008399	active site
444177008400	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
444177008401	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
444177008402	tetramer interface [polypeptide binding]; other site
444177008403	active site
444177008404	Mg2+/Mn2+ binding site [ion binding]; other site
444177008405	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
444177008406	2-methylcitrate dehydratase; Region: prpD; TIGR02330
444177008407	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
444177008408	dimer interface [polypeptide binding]; other site
444177008409	Citrate synthase; Region: Citrate_synt; pfam00285
444177008410	active site
444177008411	coenzyme A binding site [chemical binding]; other site
444177008412	citrylCoA binding site [chemical binding]; other site
444177008413	oxalacetate/citrate binding site [chemical binding]; other site
444177008414	catalytic triad [active]
444177008415	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
444177008416	nudix motif; other site
444177008417	nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769
444177008418	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177008419	Walker A/P-loop; other site
444177008420	ATP binding site [chemical binding]; other site
444177008421	Q-loop/lid; other site
444177008422	ABC transporter signature motif; other site
444177008423	Walker B; other site
444177008424	D-loop; other site
444177008425	H-loop/switch region; other site
444177008426	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177008427	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
444177008428	Walker A/P-loop; other site
444177008429	ATP binding site [chemical binding]; other site
444177008430	Q-loop/lid; other site
444177008431	ABC transporter signature motif; other site
444177008432	Walker B; other site
444177008433	D-loop; other site
444177008434	H-loop/switch region; other site
444177008435	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
444177008436	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
444177008437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177008438	dimer interface [polypeptide binding]; other site
444177008439	conserved gate region; other site
444177008440	putative PBP binding loops; other site
444177008441	ABC-ATPase subunit interface; other site
444177008442	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177008443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177008444	dimer interface [polypeptide binding]; other site
444177008445	conserved gate region; other site
444177008446	putative PBP binding loops; other site
444177008447	ABC-ATPase subunit interface; other site
444177008448	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
444177008449	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
444177008450	substrate binding site [chemical binding]; other site
444177008451	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
444177008452	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
444177008453	substrate binding site [chemical binding]; other site
444177008454	THF binding site; other site
444177008455	zinc-binding site [ion binding]; other site
444177008456	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
444177008457	THF binding site; other site
444177008458	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
444177008459	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
444177008460	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
444177008461	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
444177008462	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
444177008463	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
444177008464	Protein of unknown function (DUF4085); Region: DUF4085; pfam13315
444177008465	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
444177008466	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
444177008467	Low molecular weight phosphatase family; Region: LMWPc; cd00115
444177008468	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
444177008469	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
444177008470	arsenical-resistance protein; Region: acr3; TIGR00832
444177008471	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177008472	dimerization interface [polypeptide binding]; other site
444177008473	putative DNA binding site [nucleotide binding]; other site
444177008474	putative Zn2+ binding site [ion binding]; other site
444177008475	BclB C-terminal domain; Region: exospore_TM; TIGR03721
444177008476	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
444177008477	FAD binding domain; Region: FAD_binding_4; pfam01565
444177008478	MraW methylase family; Region: Methyltransf_5; cl17771
444177008479	Berberine and berberine like; Region: BBE; pfam08031
444177008480	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
444177008481	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
444177008482	DinB superfamily; Region: DinB_2; pfam12867
444177008483	DinB family; Region: DinB; cl17821
444177008484	Chloramphenicol acetyltransferase; Region: CAT; cl02008
444177008485	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
444177008486	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
444177008487	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
444177008488	Cu(I) binding site [ion binding]; other site
444177008489	Protein of unknown function, DUF485; Region: DUF485; pfam04341
444177008490	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
444177008491	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
444177008492	Na binding site [ion binding]; other site
444177008493	Protein of unknown function, DUF485; Region: DUF485; pfam04341
444177008494	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
444177008495	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
444177008496	Walker A/P-loop; other site
444177008497	ATP binding site [chemical binding]; other site
444177008498	Q-loop/lid; other site
444177008499	ABC transporter signature motif; other site
444177008500	Walker B; other site
444177008501	D-loop; other site
444177008502	H-loop/switch region; other site
444177008503	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
444177008504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177008505	dimer interface [polypeptide binding]; other site
444177008506	conserved gate region; other site
444177008507	putative PBP binding loops; other site
444177008508	ABC-ATPase subunit interface; other site
444177008509	Domain of unknown function DUF77; Region: DUF77; pfam01910
444177008510	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
444177008511	NMT1/THI5 like; Region: NMT1; pfam09084
444177008512	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
444177008513	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177008514	Mg2+ binding site [ion binding]; other site
444177008515	G-X-G motif; other site
444177008516	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
444177008517	anchoring element; other site
444177008518	dimer interface [polypeptide binding]; other site
444177008519	ATP binding site [chemical binding]; other site
444177008520	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
444177008521	active site
444177008522	putative metal-binding site [ion binding]; other site
444177008523	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
444177008524	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
444177008525	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
444177008526	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177008527	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177008528	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177008529	Spore germination protein; Region: Spore_permease; cl17796
444177008530	Homoserine O-succinyltransferase; Region: HTS; pfam04204
444177008531	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
444177008532	proposed active site lysine [active]
444177008533	conserved cys residue [active]
444177008534	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
444177008535	GIY-YIG motif/motif A; other site
444177008536	active site
444177008537	catalytic site [active]
444177008538	putative DNA binding site [nucleotide binding]; other site
444177008539	metal binding site [ion binding]; metal-binding site
444177008540	Predicted transcriptional regulators [Transcription]; Region: COG1378
444177008541	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
444177008542	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
444177008543	C-terminal domain interface [polypeptide binding]; other site
444177008544	sugar binding site [chemical binding]; other site
444177008545	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
444177008546	Na binding site [ion binding]; other site
444177008547	Protein of unknown function (DUF997); Region: DUF997; pfam06196
444177008548	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
444177008549	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742
444177008550	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
444177008551	ligand binding site [chemical binding]; other site
444177008552	flexible hinge region; other site
444177008553	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
444177008554	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
444177008555	Cupin; Region: Cupin_1; smart00835
444177008556	Cupin; Region: Cupin_1; smart00835
444177008557	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
444177008558	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177008559	DNA-binding site [nucleotide binding]; DNA binding site
444177008560	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177008561	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177008562	homodimer interface [polypeptide binding]; other site
444177008563	catalytic residue [active]
444177008564	Lysine efflux permease [General function prediction only]; Region: COG1279
444177008565	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
444177008566	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
444177008567	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
444177008568	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
444177008569	putative DNA binding site [nucleotide binding]; other site
444177008570	AsnC family; Region: AsnC_trans_reg; pfam01037
444177008571	S-layer homology domain; Region: SLH; pfam00395
444177008572	S-layer homology domain; Region: SLH; pfam00395
444177008573	S-layer homology domain; Region: SLH; pfam00395
444177008574	aconitate hydratase; Validated; Region: PRK09277
444177008575	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
444177008576	substrate binding site [chemical binding]; other site
444177008577	ligand binding site [chemical binding]; other site
444177008578	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
444177008579	substrate binding site [chemical binding]; other site
444177008580	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
444177008581	Phage XkdN-like protein; Region: XkdN; pfam08890
444177008582	Phage XkdN-like protein; Region: XkdN; pfam08890
444177008583	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
444177008584	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177008585	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13315
444177008586	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
444177008587	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
444177008588	Walker A/P-loop; other site
444177008589	ATP binding site [chemical binding]; other site
444177008590	Q-loop/lid; other site
444177008591	ABC transporter signature motif; other site
444177008592	Walker B; other site
444177008593	D-loop; other site
444177008594	H-loop/switch region; other site
444177008595	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
444177008596	Predicted transcriptional regulators [Transcription]; Region: COG1695
444177008597	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177008598	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
444177008599	Coenzyme A binding pocket [chemical binding]; other site
444177008600	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177008601	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177008602	dimer interface [polypeptide binding]; other site
444177008603	putative CheW interface [polypeptide binding]; other site
444177008604	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177008605	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633
444177008606	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
444177008607	active site
444177008608	DNA binding site [nucleotide binding]
444177008609	LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866
444177008610	nucleotide binding site [chemical binding]; other site
444177008611	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
444177008612	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
444177008613	putative DNA binding site [nucleotide binding]; other site
444177008614	putative homodimer interface [polypeptide binding]; other site
444177008615	topology modulation protein; Reviewed; Region: PRK08118
444177008616	AAA domain; Region: AAA_17; pfam13207
444177008617	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
444177008618	RibD C-terminal domain; Region: RibD_C; cl17279
444177008619	Predicted transcriptional regulator [Transcription]; Region: COG2378
444177008620	HTH domain; Region: HTH_11; pfam08279
444177008621	WYL domain; Region: WYL; pfam13280
444177008622	Predicted membrane protein [Function unknown]; Region: COG2311
444177008623	Protein of unknown function (DUF418); Region: DUF418; pfam04235
444177008624	Transposase domain (DUF772); Region: DUF772; pfam05598
444177008625	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
444177008626	homotrimer interaction site [polypeptide binding]; other site
444177008627	putative active site [active]
444177008628	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
444177008629	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
444177008630	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177008631	FeS/SAM binding site; other site
444177008632	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
444177008633	active site
444177008634	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
444177008635	Ligand Binding Site [chemical binding]; other site
444177008636	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
444177008637	S-layer homology domain; Region: SLH; pfam00395
444177008638	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
444177008639	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
444177008640	active site
444177008641	Zn binding site [ion binding]; other site
444177008642	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177008643	S-adenosylmethionine binding site [chemical binding]; other site
444177008644	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
444177008645	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177008646	active site
444177008647	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
444177008648	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
444177008649	active site
444177008650	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
444177008651	CotJB protein; Region: CotJB; pfam12652
444177008652	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
444177008653	Predicted transcriptional regulators [Transcription]; Region: COG1733
444177008654	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177008655	putative DNA binding site [nucleotide binding]; other site
444177008656	putative Zn2+ binding site [ion binding]; other site
444177008657	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
444177008658	dimer interface [polypeptide binding]; other site
444177008659	FMN binding site [chemical binding]; other site
444177008660	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177008661	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
444177008662	Coenzyme A binding pocket [chemical binding]; other site
444177008663	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
444177008664	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
444177008665	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
444177008666	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
444177008667	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
444177008668	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
444177008669	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
444177008670	active site
444177008671	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
444177008672	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
444177008673	Phage terminase large subunit; Region: Terminase_3; cl12054
444177008674	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177008675	Uncharacterized conserved protein [Function unknown]; Region: COG1633
444177008676	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
444177008677	dinuclear metal binding motif [ion binding]; other site
444177008678	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
444177008679	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
444177008680	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177008681	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177008682	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
444177008683	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177008684	Coenzyme A binding pocket [chemical binding]; other site
444177008685	Predicted transcriptional regulators [Transcription]; Region: COG1510
444177008686	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
444177008687	putative Zn2+ binding site [ion binding]; other site
444177008688	putative DNA binding site [nucleotide binding]; other site
444177008689	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
444177008690	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
444177008691	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
444177008692	Chitin binding domain; Region: Chitin_bind_3; pfam03067
444177008693	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
444177008694	Interdomain contacts; other site
444177008695	Cytokine receptor motif; other site
444177008696	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
444177008697	Interdomain contacts; other site
444177008698	Cytokine receptor motif; other site
444177008699	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
444177008700	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177008701	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177008702	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
444177008703	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177008704	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177008705	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
444177008706	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
444177008707	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
444177008708	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
444177008709	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
444177008710	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
444177008711	classical (c) SDRs; Region: SDR_c; cd05233
444177008712	NAD(P) binding site [chemical binding]; other site
444177008713	active site
444177008714	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
444177008715	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
444177008716	RNA polymerase sigma factor SigM; Provisional; Region: PRK09644
444177008717	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177008718	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177008719	DNA binding residues [nucleotide binding]
444177008720	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177008721	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
444177008722	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
444177008723	Predicted transcriptional regulator [Transcription]; Region: COG2378
444177008724	HTH domain; Region: HTH_11; pfam08279
444177008725	WYL domain; Region: WYL; pfam13280
444177008726	YolD-like protein; Region: YolD; pfam08863
444177008727	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
444177008728	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
444177008729	active site
444177008730	catalytic residues [active]
444177008731	DNA binding site [nucleotide binding]
444177008732	Int/Topo IB signature motif; other site
444177008733	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
444177008734	active site
444177008735	catalytic residues [active]
444177008736	DNA binding site [nucleotide binding]
444177008737	Int/Topo IB signature motif; other site
444177008738	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177008739	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177008740	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177008741	cellulose synthase A; Region: PLN02195
444177008742	Insecticidal Crystal Toxin, P42; Region: Toxin_10; pfam05431
444177008743	Insecticidal Crystal Toxin, P42; Region: Toxin_10; pfam05431
444177008744	CryBP1 protein; Region: CryBP1; pfam07029
444177008745	Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318
444177008746	Condensation domain; Region: Condensation; pfam00668
444177008747	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
444177008748	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
444177008749	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
444177008750	acyl-activating enzyme (AAE) consensus motif; other site
444177008751	AMP binding site [chemical binding]; other site
444177008752	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
444177008753	Condensation domain; Region: Condensation; pfam00668
444177008754	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
444177008755	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
444177008756	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
444177008757	acyl-activating enzyme (AAE) consensus motif; other site
444177008758	AMP binding site [chemical binding]; other site
444177008759	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
444177008760	thioester reductase domain; Region: Thioester-redct; TIGR01746
444177008761	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
444177008762	putative NAD(P) binding site [chemical binding]; other site
444177008763	active site
444177008764	putative substrate binding site [chemical binding]; other site
444177008765	Chitin binding domain; Region: Chitin_bind_3; pfam03067
444177008766	YolD-like protein; Region: YolD; pfam08863
444177008767	DNA polymerase IV; Reviewed; Region: PRK03103
444177008768	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
444177008769	active site
444177008770	DNA binding site [nucleotide binding]
444177008771	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
444177008772	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
444177008773	Uncharacterized conserved protein [Function unknown]; Region: COG2128
444177008774	Predicted transcriptional regulator [Transcription]; Region: COG1959
444177008775	Transcriptional regulator; Region: Rrf2; pfam02082
444177008776	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
444177008777	dimer interface [polypeptide binding]; other site
444177008778	FMN binding site [chemical binding]; other site
444177008779	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
444177008780	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177008781	MarR family; Region: MarR_2; pfam12802
444177008782	Protein of unknown function (DUF554); Region: DUF554; pfam04474
444177008783	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
444177008784	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
444177008785	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
444177008786	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177008787	active site
444177008788	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177008789	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177008790	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
444177008791	Penicillinase repressor; Region: Pencillinase_R; cl17580
444177008792	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
444177008793	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177008794	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177008795	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
444177008796	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177008797	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177008798	Coenzyme A binding pocket [chemical binding]; other site
444177008799	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
444177008800	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
444177008801	TPR repeat; Region: TPR_11; pfam13414
444177008802	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177008803	binding surface
444177008804	TPR motif; other site
444177008805	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
444177008806	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
444177008807	Phosphotransferase enzyme family; Region: APH; pfam01636
444177008808	putative active site [active]
444177008809	putative substrate binding site [chemical binding]; other site
444177008810	ATP binding site [chemical binding]; other site
444177008811	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
444177008812	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177008813	NAD(P) binding site [chemical binding]; other site
444177008814	active site
444177008815	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
444177008816	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
444177008817	FAD binding site [chemical binding]; other site
444177008818	substrate binding site [chemical binding]; other site
444177008819	catalytic base [active]
444177008820	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177008821	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177008822	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
444177008823	dimerization interface [polypeptide binding]; other site
444177008824	formimidoylglutamase; Provisional; Region: PRK13775
444177008825	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
444177008826	putative active site [active]
444177008827	putative metal binding site [ion binding]; other site
444177008828	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
444177008829	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
444177008830	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
444177008831	NodB motif; other site
444177008832	active site
444177008833	catalytic site [active]
444177008834	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
444177008835	putative dimer interface [polypeptide binding]; other site
444177008836	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177008837	ligand binding site [chemical binding]; other site
444177008838	Zn binding site [ion binding]; other site
444177008839	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
444177008840	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177008841	Coenzyme A binding pocket [chemical binding]; other site
444177008842	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
444177008843	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
444177008844	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
444177008845	catalytic core [active]
444177008846	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
444177008847	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177008848	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177008849	DinB superfamily; Region: DinB_2; pfam12867
444177008850	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
444177008851	stage V sporulation protein K; Region: spore_V_K; TIGR02881
444177008852	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177008853	Walker A motif; other site
444177008854	ATP binding site [chemical binding]; other site
444177008855	Walker B motif; other site
444177008856	arginine finger; other site
444177008857	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
444177008858	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
444177008859	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177008860	Coenzyme A binding pocket [chemical binding]; other site
444177008861	Uncharacterized conserved protein [Function unknown]; Region: COG1434
444177008862	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
444177008863	putative active site [active]
444177008864	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
444177008865	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
444177008866	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
444177008867	Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
444177008868	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
444177008869	Integrase core domain; Region: rve_3; cl15866
444177008870	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
444177008871	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
444177008872	active site
444177008873	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
444177008874	active site
444177008875	ATP binding site [chemical binding]; other site
444177008876	substrate binding site [chemical binding]; other site
444177008877	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
444177008878	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177008879	Coenzyme A binding pocket [chemical binding]; other site
444177008880	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
444177008881	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177008882	Coenzyme A binding pocket [chemical binding]; other site
444177008883	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177008884	Predicted membrane protein [Function unknown]; Region: COG2323
444177008885	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177008886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177008887	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177008888	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177008889	YolD-like protein; Region: YolD; pfam08863
444177008890	Cupin; Region: Cupin_1; smart00835
444177008891	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
444177008892	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
444177008893	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
444177008894	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
444177008895	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
444177008896	Soluble P-type ATPase [General function prediction only]; Region: COG4087
444177008897	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
444177008898	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
444177008899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177008900	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
444177008901	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
444177008902	Catalytic site [active]
444177008903	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
444177008904	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
444177008905	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
444177008906	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
444177008907	active site
444177008908	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
444177008909	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
444177008910	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177008911	catalytic residue [active]
444177008912	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
444177008913	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
444177008914	Bacterial transcriptional regulator; Region: IclR; pfam01614
444177008915	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177008916	MarR family; Region: MarR_2; pfam12802
444177008917	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
444177008918	classical (c) SDRs; Region: SDR_c; cd05233
444177008919	NAD(P) binding site [chemical binding]; other site
444177008920	active site
444177008921	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
444177008922	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
444177008923	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
444177008924	Walker A/P-loop; other site
444177008925	ATP binding site [chemical binding]; other site
444177008926	Q-loop/lid; other site
444177008927	ABC transporter signature motif; other site
444177008928	Walker B; other site
444177008929	D-loop; other site
444177008930	H-loop/switch region; other site
444177008931	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
444177008932	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
444177008933	Methyltransferase domain; Region: Methyltransf_23; pfam13489
444177008934	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177008935	S-adenosylmethionine binding site [chemical binding]; other site
444177008936	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
444177008937	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177008938	FeS/SAM binding site; other site
444177008939	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
444177008940	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
444177008941	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
444177008942	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
444177008943	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
444177008944	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
444177008945	active site
444177008946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177008947	KR domain; Region: KR; pfam08659
444177008948	NAD(P) binding site [chemical binding]; other site
444177008949	active site
444177008950	H+ Antiporter protein; Region: 2A0121; TIGR00900
444177008951	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
444177008952	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
444177008953	active site
444177008954	Condensation domain; Region: Condensation; pfam00668
444177008955	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
444177008956	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
444177008957	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
444177008958	Methyltransferase domain; Region: Methyltransf_23; pfam13489
444177008959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177008960	S-adenosylmethionine binding site [chemical binding]; other site
444177008961	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
444177008962	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
444177008963	acyl-activating enzyme (AAE) consensus motif; other site
444177008964	acyl-activating enzyme (AAE) consensus motif; other site
444177008965	AMP binding site [chemical binding]; other site
444177008966	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
444177008967	Condensation domain; Region: Condensation; pfam00668
444177008968	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
444177008969	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
444177008970	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
444177008971	Helix-turn-helix domain; Region: HTH_17; pfam12728
444177008972	PBP superfamily domain; Region: PBP_like; pfam12727
444177008973	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
444177008974	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
444177008975	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
444177008976	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177008977	dimer interface [polypeptide binding]; other site
444177008978	conserved gate region; other site
444177008979	putative PBP binding loops; other site
444177008980	ABC-ATPase subunit interface; other site
444177008981	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
444177008982	MoaE interaction surface [polypeptide binding]; other site
444177008983	MoeB interaction surface [polypeptide binding]; other site
444177008984	thiocarboxylated glycine; other site
444177008985	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
444177008986	MoaE homodimer interface [polypeptide binding]; other site
444177008987	MoaD interaction [polypeptide binding]; other site
444177008988	active site residues [active]
444177008989	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
444177008990	Walker A motif; other site
444177008991	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
444177008992	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
444177008993	dimer interface [polypeptide binding]; other site
444177008994	putative functional site; other site
444177008995	putative MPT binding site; other site
444177008996	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
444177008997	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
444177008998	ATP binding site [chemical binding]; other site
444177008999	substrate interface [chemical binding]; other site
444177009000	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
444177009001	MPT binding site; other site
444177009002	trimer interface [polypeptide binding]; other site
444177009003	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
444177009004	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
444177009005	GTP binding site; other site
444177009006	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
444177009007	trimer interface [polypeptide binding]; other site
444177009008	dimer interface [polypeptide binding]; other site
444177009009	putative active site [active]
444177009010	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
444177009011	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177009012	FeS/SAM binding site; other site
444177009013	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
444177009014	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
444177009015	Uncharacterized conserved protein [Function unknown]; Region: COG5609
444177009016	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
444177009017	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
444177009018	catalytic loop [active]
444177009019	iron binding site [ion binding]; other site
444177009020	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
444177009021	4Fe-4S binding domain; Region: Fer4; pfam00037
444177009022	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
444177009023	[4Fe-4S] binding site [ion binding]; other site
444177009024	molybdopterin cofactor binding site; other site
444177009025	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
444177009026	molybdopterin cofactor binding site; other site
444177009027	Uncharacterized conserved protein [Function unknown]; Region: COG2427
444177009028	Domain of unknown function DUF59; Region: DUF59; pfam01883
444177009029	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
444177009030	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
444177009031	Walker A motif; other site
444177009032	PQQ-like domain; Region: PQQ_2; pfam13360
444177009033	Uncharacterized protein family (UPF0167); Region: UPF0167; pfam03691
444177009034	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
444177009035	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177009036	dimerization interface [polypeptide binding]; other site
444177009037	putative DNA binding site [nucleotide binding]; other site
444177009038	putative Zn2+ binding site [ion binding]; other site
444177009039	EamA-like transporter family; Region: EamA; pfam00892
444177009040	EamA-like transporter family; Region: EamA; pfam00892
444177009041	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177009042	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177009043	dimerization interface [polypeptide binding]; other site
444177009044	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177009045	dimer interface [polypeptide binding]; other site
444177009046	phosphorylation site [posttranslational modification]
444177009047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177009048	ATP binding site [chemical binding]; other site
444177009049	Mg2+ binding site [ion binding]; other site
444177009050	G-X-G motif; other site
444177009051	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177009052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177009053	active site
444177009054	phosphorylation site [posttranslational modification]
444177009055	intermolecular recognition site; other site
444177009056	dimerization interface [polypeptide binding]; other site
444177009057	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177009058	DNA binding site [nucleotide binding]
444177009059	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
444177009060	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
444177009061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177009062	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177009063	putative substrate translocation pore; other site
444177009064	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177009065	dimerization interface [polypeptide binding]; other site
444177009066	putative DNA binding site [nucleotide binding]; other site
444177009067	putative Zn2+ binding site [ion binding]; other site
444177009068	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
444177009069	active site residue [active]
444177009070	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177009071	putative substrate translocation pore; other site
444177009072	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
444177009073	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177009074	ABC-ATPase subunit  interface; other site
444177009075	dimer interface [polypeptide binding]; other site
444177009076	putative PBP binding regions; other site
444177009077	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
444177009078	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
444177009079	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
444177009080	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177009081	intersubunit interface [polypeptide binding]; other site
444177009082	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
444177009083	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177009084	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
444177009085	classical (c) SDRs; Region: SDR_c; cd05233
444177009086	NAD(P) binding site [chemical binding]; other site
444177009087	active site
444177009088	S-layer homology domain; Region: SLH; pfam00395
444177009089	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
444177009090	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
444177009091	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
444177009092	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
444177009093	Right handed beta helix region; Region: Beta_helix; pfam13229
444177009094	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
444177009095	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
444177009096	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
444177009097	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
444177009098	active site
444177009099	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
444177009100	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
444177009101	Predicted membrane protein [Function unknown]; Region: COG2364
444177009102	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
444177009103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177009104	active site
444177009105	motif I; other site
444177009106	motif II; other site
444177009107	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
444177009108	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177009109	FeS/SAM binding site; other site
444177009110	YfkB-like domain; Region: YfkB; pfam08756
444177009111	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
444177009112	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
444177009113	hypothetical protein; Provisional; Region: PRK10621
444177009114	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
444177009115	hypothetical protein; Provisional; Region: PRK10621
444177009116	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
444177009117	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177009118	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177009119	DNA binding residues [nucleotide binding]
444177009120	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
444177009121	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
444177009122	Spore germination protein; Region: Spore_permease; cl17796
444177009123	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177009124	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
444177009125	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
444177009126	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
444177009127	Walker A/P-loop; other site
444177009128	ATP binding site [chemical binding]; other site
444177009129	Q-loop/lid; other site
444177009130	ABC transporter signature motif; other site
444177009131	Walker B; other site
444177009132	D-loop; other site
444177009133	H-loop/switch region; other site
444177009134	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
444177009135	Ferritin-like domain; Region: Ferritin; pfam00210
444177009136	ferroxidase diiron center [ion binding]; other site
444177009137	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
444177009138	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
444177009139	active site
444177009140	NAD binding site [chemical binding]; other site
444177009141	metal binding site [ion binding]; metal-binding site
444177009142	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177009143	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
444177009144	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
444177009145	NAD(P) binding site [chemical binding]; other site
444177009146	catalytic residues [active]
444177009147	Transcriptional regulators [Transcription]; Region: PurR; COG1609
444177009148	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
444177009149	DNA binding site [nucleotide binding]
444177009150	domain linker motif; other site
444177009151	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
444177009152	dimerization interface [polypeptide binding]; other site
444177009153	ligand binding site [chemical binding]; other site
444177009154	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
444177009155	hypothetical protein; Reviewed; Region: PRK09588
444177009156	Protein of unknown function, DUF258; Region: DUF258; pfam03193
444177009157	Dynamin family; Region: Dynamin_N; pfam00350
444177009158	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
444177009159	GTP/Mg2+ binding site [chemical binding]; other site
444177009160	G2 box; other site
444177009161	Switch I region; other site
444177009162	G3 box; other site
444177009163	Switch II region; other site
444177009164	G4 box; other site
444177009165	G5 box; other site
444177009166	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
444177009167	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
444177009168	substrate binding site [chemical binding]; other site
444177009169	dimer interface [polypeptide binding]; other site
444177009170	ATP binding site [chemical binding]; other site
444177009171	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
444177009172	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
444177009173	substrate binding site [chemical binding]; other site
444177009174	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
444177009175	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
444177009176	substrate binding site [chemical binding]; other site
444177009177	ligand binding site [chemical binding]; other site
444177009178	tartrate dehydrogenase; Region: TTC; TIGR02089
444177009179	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
444177009180	2-isopropylmalate synthase; Validated; Region: PRK00915
444177009181	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
444177009182	active site
444177009183	catalytic residues [active]
444177009184	metal binding site [ion binding]; metal-binding site
444177009185	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
444177009186	ketol-acid reductoisomerase; Provisional; Region: PRK05479
444177009187	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
444177009188	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
444177009189	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
444177009190	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
444177009191	putative valine binding site [chemical binding]; other site
444177009192	dimer interface [polypeptide binding]; other site
444177009193	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
444177009194	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
444177009195	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
444177009196	PYR/PP interface [polypeptide binding]; other site
444177009197	dimer interface [polypeptide binding]; other site
444177009198	TPP binding site [chemical binding]; other site
444177009199	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
444177009200	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
444177009201	TPP-binding site [chemical binding]; other site
444177009202	dimer interface [polypeptide binding]; other site
444177009203	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
444177009204	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
444177009205	FAD binding domain; Region: FAD_binding_4; pfam01565
444177009206	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
444177009207	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
444177009208	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
444177009209	dimer interface [polypeptide binding]; other site
444177009210	active site
444177009211	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
444177009212	substrate binding site [chemical binding]; other site
444177009213	catalytic residue [active]
444177009214	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
444177009215	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
444177009216	N-acetyl-D-glucosamine binding site [chemical binding]; other site
444177009217	catalytic residue [active]
444177009218	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
444177009219	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
444177009220	cystathionine gamma-synthase; Reviewed; Region: PRK08247
444177009221	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
444177009222	homodimer interface [polypeptide binding]; other site
444177009223	substrate-cofactor binding pocket; other site
444177009224	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177009225	catalytic residue [active]
444177009226	cystathionine beta-lyase; Provisional; Region: PRK08064
444177009227	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
444177009228	homodimer interface [polypeptide binding]; other site
444177009229	substrate-cofactor binding pocket; other site
444177009230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177009231	catalytic residue [active]
444177009232	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
444177009233	nudix motif; other site
444177009234	Cupin; Region: Cupin_6; pfam12852
444177009235	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
444177009236	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
444177009237	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
444177009238	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
444177009239	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
444177009240	argininosuccinate lyase; Provisional; Region: PRK00855
444177009241	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
444177009242	active sites [active]
444177009243	tetramer interface [polypeptide binding]; other site
444177009244	argininosuccinate synthase; Provisional; Region: PRK13820
444177009245	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
444177009246	ANP binding site [chemical binding]; other site
444177009247	Substrate Binding Site II [chemical binding]; other site
444177009248	Substrate Binding Site I [chemical binding]; other site
444177009249	CAAX protease self-immunity; Region: Abi; pfam02517
444177009250	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
444177009251	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
444177009252	DNA binding residues [nucleotide binding]
444177009253	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
444177009254	classical (c) SDRs; Region: SDR_c; cd05233
444177009255	NAD(P) binding site [chemical binding]; other site
444177009256	active site
444177009257	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177009258	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
444177009259	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
444177009260	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
444177009261	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
444177009262	active site
444177009263	FMN binding site [chemical binding]; other site
444177009264	substrate binding site [chemical binding]; other site
444177009265	homotetramer interface [polypeptide binding]; other site
444177009266	catalytic residue [active]
444177009267	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
444177009268	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
444177009269	Protein of unknown function (DUF2691); Region: DUF2691; pfam10903
444177009270	Predicted flavoprotein [General function prediction only]; Region: COG0431
444177009271	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
444177009272	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
444177009273	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
444177009274	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
444177009275	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177009276	Zn binding site [ion binding]; other site
444177009277	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
444177009278	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177009279	Zn binding site [ion binding]; other site
444177009280	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177009281	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177009282	putative Zn2+ binding site [ion binding]; other site
444177009283	putative DNA binding site [nucleotide binding]; other site
444177009284	Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372
444177009285	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
444177009286	ribonuclease Z; Region: RNase_Z; TIGR02651
444177009287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177009288	S-adenosylmethionine binding site [chemical binding]; other site
444177009289	cobyric acid synthase; Provisional; Region: PRK00784
444177009290	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
444177009291	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
444177009292	catalytic triad [active]
444177009293	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
444177009294	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
444177009295	putative FMN binding site [chemical binding]; other site
444177009296	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
444177009297	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
444177009298	active site
444177009299	SAM binding site [chemical binding]; other site
444177009300	homodimer interface [polypeptide binding]; other site
444177009301	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
444177009302	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
444177009303	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
444177009304	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
444177009305	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
444177009306	catalytic triad [active]
444177009307	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
444177009308	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
444177009309	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
444177009310	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
444177009311	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
444177009312	active site
444177009313	SAM binding site [chemical binding]; other site
444177009314	homodimer interface [polypeptide binding]; other site
444177009315	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
444177009316	homodimer interface [polypeptide binding]; other site
444177009317	active site
444177009318	SAM binding site [chemical binding]; other site
444177009319	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
444177009320	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
444177009321	Precorrin-8X methylmutase; Region: CbiC; pfam02570
444177009322	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
444177009323	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
444177009324	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
444177009325	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
444177009326	putative active site [active]
444177009327	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
444177009328	putative active site [active]
444177009329	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
444177009330	active site
444177009331	SAM binding site [chemical binding]; other site
444177009332	homodimer interface [polypeptide binding]; other site
444177009333	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
444177009334	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
444177009335	dimer interface [polypeptide binding]; other site
444177009336	[2Fe-2S] cluster binding site [ion binding]; other site
444177009337	cobalt transport protein CbiM; Validated; Region: PRK08319
444177009338	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
444177009339	cobalt transport protein CbiN; Provisional; Region: PRK02898
444177009340	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
444177009341	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636
444177009342	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
444177009343	Walker A/P-loop; other site
444177009344	ATP binding site [chemical binding]; other site
444177009345	Q-loop/lid; other site
444177009346	ABC transporter signature motif; other site
444177009347	Walker B; other site
444177009348	D-loop; other site
444177009349	H-loop/switch region; other site
444177009350	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
444177009351	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
444177009352	active site
444177009353	catalytic triad [active]
444177009354	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
444177009355	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
444177009356	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177009357	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177009358	Coenzyme A binding pocket [chemical binding]; other site
444177009359	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
444177009360	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
444177009361	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
444177009362	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
444177009363	Ligand binding site; other site
444177009364	Putative Catalytic site; other site
444177009365	DXD motif; other site
444177009366	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
444177009367	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
444177009368	NAD(P) binding site [chemical binding]; other site
444177009369	homodimer interface [polypeptide binding]; other site
444177009370	substrate binding site [chemical binding]; other site
444177009371	active site
444177009372	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
444177009373	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
444177009374	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177009375	NAD(P) binding site [chemical binding]; other site
444177009376	active site
444177009377	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
444177009378	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
444177009379	nucleophilic elbow; other site
444177009380	catalytic triad; other site
444177009381	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
444177009382	DNA polymerase IV; Validated; Region: PRK01810
444177009383	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
444177009384	active site
444177009385	DNA binding site [nucleotide binding]
444177009386	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
444177009387	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177009388	DNA-binding site [nucleotide binding]; DNA binding site
444177009389	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177009390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177009391	homodimer interface [polypeptide binding]; other site
444177009392	catalytic residue [active]
444177009393	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
444177009394	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177009395	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177009396	homodimer interface [polypeptide binding]; other site
444177009397	catalytic residue [active]
444177009398	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
444177009399	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177009400	non-specific DNA binding site [nucleotide binding]; other site
444177009401	salt bridge; other site
444177009402	sequence-specific DNA binding site [nucleotide binding]; other site
444177009403	Cupin domain; Region: Cupin_2; pfam07883
444177009404	LysE type translocator; Region: LysE; cl00565
444177009405	biotin synthase; Validated; Region: PRK06256
444177009406	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177009407	FeS/SAM binding site; other site
444177009408	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
444177009409	BioY family; Region: BioY; pfam02632
444177009410	AAA domain; Region: AAA_26; pfam13500
444177009411	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
444177009412	Cupin domain; Region: Cupin_2; cl17218
444177009413	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177009414	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177009415	EamA-like transporter family; Region: EamA; pfam00892
444177009416	LysE type translocator; Region: LysE; pfam01810
444177009417	TPR repeat; Region: TPR_11; pfam13414
444177009418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177009419	binding surface
444177009420	TPR motif; other site
444177009421	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
444177009422	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177009423	dimerization interface [polypeptide binding]; other site
444177009424	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177009425	dimer interface [polypeptide binding]; other site
444177009426	putative CheW interface [polypeptide binding]; other site
444177009427	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
444177009428	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177009429	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
444177009430	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
444177009431	dimer interface [polypeptide binding]; other site
444177009432	active site
444177009433	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
444177009434	catalytic residues [active]
444177009435	substrate binding site [chemical binding]; other site
444177009436	CheW-like domain; Region: CheW; pfam01584
444177009437	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
444177009438	peptidase T-like protein; Region: PepT-like; TIGR01883
444177009439	metal binding site [ion binding]; metal-binding site
444177009440	putative dimer interface [polypeptide binding]; other site
444177009441	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
444177009442	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
444177009443	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
444177009444	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177009445	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
444177009446	dimer interface [polypeptide binding]; other site
444177009447	substrate binding site [chemical binding]; other site
444177009448	metal binding site [ion binding]; metal-binding site
444177009449	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
444177009450	Predicted membrane protein [Function unknown]; Region: COG4129
444177009451	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
444177009452	Disulphide isomerase; Region: Disulph_isomer; pfam06491
444177009453	membrane ATPase/protein kinase; Provisional; Region: PRK09435
444177009454	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
444177009455	GTP/Mg2+ binding site [chemical binding]; other site
444177009456	G4 box; other site
444177009457	G5 box; other site
444177009458	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
444177009459	Walker A; other site
444177009460	G1 box; other site
444177009461	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
444177009462	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
444177009463	active site
444177009464	substrate binding site [chemical binding]; other site
444177009465	coenzyme B12 binding site [chemical binding]; other site
444177009466	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
444177009467	B12 binding site [chemical binding]; other site
444177009468	cobalt ligand [ion binding]; other site
444177009469	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
444177009470	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
444177009471	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
444177009472	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
444177009473	E3 interaction surface; other site
444177009474	lipoyl attachment site [posttranslational modification]; other site
444177009475	e3 binding domain; Region: E3_binding; pfam02817
444177009476	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
444177009477	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
444177009478	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
444177009479	alpha subunit interface [polypeptide binding]; other site
444177009480	TPP binding site [chemical binding]; other site
444177009481	heterodimer interface [polypeptide binding]; other site
444177009482	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
444177009483	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
444177009484	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
444177009485	tetramer interface [polypeptide binding]; other site
444177009486	TPP-binding site [chemical binding]; other site
444177009487	heterodimer interface [polypeptide binding]; other site
444177009488	phosphorylation loop region [posttranslational modification]
444177009489	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
444177009490	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
444177009491	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
444177009492	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
444177009493	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
444177009494	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
444177009495	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
444177009496	NAD binding site [chemical binding]; other site
444177009497	Phe binding site; other site
444177009498	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
444177009499	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
444177009500	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
444177009501	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
444177009502	active site
444177009503	catalytic site [active]
444177009504	Protein of unknown function (DUF342); Region: DUF342; pfam03961
444177009505	S-layer homology domain; Region: SLH; pfam00395
444177009506	S-layer homology domain; Region: SLH; pfam00395
444177009507	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
444177009508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177009509	active site
444177009510	phosphorylation site [posttranslational modification]
444177009511	intermolecular recognition site; other site
444177009512	dimerization interface [polypeptide binding]; other site
444177009513	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
444177009514	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
444177009515	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
444177009516	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
444177009517	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
444177009518	Walker A/P-loop; other site
444177009519	ATP binding site [chemical binding]; other site
444177009520	Q-loop/lid; other site
444177009521	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
444177009522	ABC transporter signature motif; other site
444177009523	Walker B; other site
444177009524	D-loop; other site
444177009525	H-loop/switch region; other site
444177009526	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
444177009527	arginine repressor; Provisional; Region: PRK04280
444177009528	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
444177009529	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
444177009530	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
444177009531	RNA binding surface [nucleotide binding]; other site
444177009532	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
444177009533	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
444177009534	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
444177009535	TPP-binding site; other site
444177009536	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
444177009537	PYR/PP interface [polypeptide binding]; other site
444177009538	dimer interface [polypeptide binding]; other site
444177009539	TPP binding site [chemical binding]; other site
444177009540	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
444177009541	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
444177009542	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
444177009543	substrate binding pocket [chemical binding]; other site
444177009544	chain length determination region; other site
444177009545	substrate-Mg2+ binding site; other site
444177009546	catalytic residues [active]
444177009547	aspartate-rich region 1; other site
444177009548	active site lid residues [active]
444177009549	aspartate-rich region 2; other site
444177009550	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
444177009551	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
444177009552	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
444177009553	generic binding surface II; other site
444177009554	generic binding surface I; other site
444177009555	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
444177009556	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
444177009557	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
444177009558	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
444177009559	homodimer interface [polypeptide binding]; other site
444177009560	NADP binding site [chemical binding]; other site
444177009561	substrate binding site [chemical binding]; other site
444177009562	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
444177009563	putative RNA binding site [nucleotide binding]; other site
444177009564	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
444177009565	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
444177009566	DNA binding residues [nucleotide binding]
444177009567	drug binding residues [chemical binding]; other site
444177009568	dimer interface [polypeptide binding]; other site
444177009569	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
444177009570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177009571	putative substrate translocation pore; other site
444177009572	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
444177009573	Asp23 family; Region: Asp23; pfam03780
444177009574	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
444177009575	metal binding site [ion binding]; metal-binding site
444177009576	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
444177009577	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177009578	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
444177009579	Walker A/P-loop; other site
444177009580	ATP binding site [chemical binding]; other site
444177009581	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177009582	active site
444177009583	DNA binding site [nucleotide binding]
444177009584	Int/Topo IB signature motif; other site
444177009585	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
444177009586	DNA binding site [nucleotide binding]
444177009587	active site
444177009588	Int/Topo IB signature motif; other site
444177009589	catalytic residues [active]
444177009590	integron integrase; Region: integrase_gron; TIGR02249
444177009591	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
444177009592	active site
444177009593	catalytic residues [active]
444177009594	DNA binding site [nucleotide binding]
444177009595	Int/Topo IB signature motif; other site
444177009596	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
444177009597	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
444177009598	ATP-grasp domain; Region: ATP-grasp_4; cl17255
444177009599	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
444177009600	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
444177009601	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
444177009602	carboxyltransferase (CT) interaction site; other site
444177009603	biotinylation site [posttranslational modification]; other site
444177009604	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
444177009605	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
444177009606	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
444177009607	Nitronate monooxygenase; Region: NMO; pfam03060
444177009608	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
444177009609	FMN binding site [chemical binding]; other site
444177009610	substrate binding site [chemical binding]; other site
444177009611	putative catalytic residue [active]
444177009612	elongation factor P; Validated; Region: PRK00529
444177009613	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
444177009614	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
444177009615	RNA binding site [nucleotide binding]; other site
444177009616	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
444177009617	RNA binding site [nucleotide binding]; other site
444177009618	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
444177009619	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
444177009620	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
444177009621	active site
444177009622	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
444177009623	Dehydroquinase class II; Region: DHquinase_II; pfam01220
444177009624	trimer interface [polypeptide binding]; other site
444177009625	active site
444177009626	dimer interface [polypeptide binding]; other site
444177009627	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
444177009628	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177009629	non-specific DNA binding site [nucleotide binding]; other site
444177009630	salt bridge; other site
444177009631	sequence-specific DNA binding site [nucleotide binding]; other site
444177009632	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
444177009633	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
444177009634	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115
444177009635	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
444177009636	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
444177009637	active site
444177009638	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
444177009639	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
444177009640	active site residue [active]
444177009641	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
444177009642	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
444177009643	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
444177009644	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
444177009645	putative metal binding site [ion binding]; other site
444177009646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177009647	D-galactonate transporter; Region: 2A0114; TIGR00893
444177009648	putative substrate translocation pore; other site
444177009649	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
444177009650	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
444177009651	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177009652	ATP binding site [chemical binding]; other site
444177009653	Mg2+ binding site [ion binding]; other site
444177009654	G-X-G motif; other site
444177009655	Bacillus competence pheromone ComX; Region: ComX; pfam05952
444177009656	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
444177009657	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
444177009658	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
444177009659	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
444177009660	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
444177009661	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
444177009662	cleavage site
444177009663	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
444177009664	SUKH-3 immunity protein; Region: SUKH-3; pfam14433
444177009665	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
444177009666	YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431
444177009667	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
444177009668	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
444177009669	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
444177009670	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
444177009671	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
444177009672	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
444177009673	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
444177009674	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
444177009675	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
444177009676	nucleotide binding site [chemical binding]; other site
444177009677	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
444177009678	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
444177009679	active site
444177009680	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
444177009681	phosphopeptide binding site; other site
444177009682	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
444177009683	phosphopeptide binding site; other site
444177009684	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
444177009685	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
444177009686	HSP70 interaction site [polypeptide binding]; other site
444177009687	Catalytic domain of Protein Kinases; Region: PKc; cd00180
444177009688	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
444177009689	active site
444177009690	ATP binding site [chemical binding]; other site
444177009691	substrate binding site [chemical binding]; other site
444177009692	activation loop (A-loop); other site
444177009693	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
444177009694	tetramer interface [polypeptide binding]; other site
444177009695	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177009696	catalytic residue [active]
444177009697	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
444177009698	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
444177009699	tetramer interface [polypeptide binding]; other site
444177009700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177009701	catalytic residue [active]
444177009702	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
444177009703	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
444177009704	shikimate kinase; Reviewed; Region: aroK; PRK00131
444177009705	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
444177009706	ADP binding site [chemical binding]; other site
444177009707	magnesium binding site [ion binding]; other site
444177009708	putative shikimate binding site; other site
444177009709	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
444177009710	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
444177009711	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
444177009712	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
444177009713	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
444177009714	Type II/IV secretion system protein; Region: T2SE; pfam00437
444177009715	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
444177009716	Walker A motif; other site
444177009717	ATP binding site [chemical binding]; other site
444177009718	Walker B motif; other site
444177009719	Helix-turn-helix domain; Region: HTH_20; pfam12840
444177009720	putative DNA binding site [nucleotide binding]; other site
444177009721	dimerization interface [polypeptide binding]; other site
444177009722	Predicted transcriptional regulator [Transcription]; Region: COG2345
444177009723	putative Zn2+ binding site [ion binding]; other site
444177009724	V4R domain; Region: V4R; cl15268
444177009725	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
444177009726	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
444177009727	Protein of unknown function (DUF2759); Region: DUF2759; pfam10958
444177009728	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
444177009729	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
444177009730	active site
444177009731	HIGH motif; other site
444177009732	dimer interface [polypeptide binding]; other site
444177009733	KMSKS motif; other site
444177009734	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
444177009735	Sulfatase; Region: Sulfatase; pfam00884
444177009736	Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543
444177009737	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
444177009738	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
444177009739	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
444177009740	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
444177009741	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
444177009742	glutamine binding [chemical binding]; other site
444177009743	catalytic triad [active]
444177009744	anthranilate synthase component I; Provisional; Region: PRK13570
444177009745	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
444177009746	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
444177009747	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
444177009748	Mechanosensitive ion channel; Region: MS_channel; pfam00924
444177009749	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
444177009750	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
444177009751	PhoU domain; Region: PhoU; pfam01895
444177009752	PhoU domain; Region: PhoU; pfam01895
444177009753	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
444177009754	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
444177009755	Walker A/P-loop; other site
444177009756	ATP binding site [chemical binding]; other site
444177009757	Q-loop/lid; other site
444177009758	ABC transporter signature motif; other site
444177009759	Walker B; other site
444177009760	D-loop; other site
444177009761	H-loop/switch region; other site
444177009762	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
444177009763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177009764	dimer interface [polypeptide binding]; other site
444177009765	conserved gate region; other site
444177009766	putative PBP binding loops; other site
444177009767	ABC-ATPase subunit interface; other site
444177009768	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
444177009769	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177009770	dimer interface [polypeptide binding]; other site
444177009771	conserved gate region; other site
444177009772	putative PBP binding loops; other site
444177009773	ABC-ATPase subunit interface; other site
444177009774	PBP superfamily domain; Region: PBP_like_2; cl17296
444177009775	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
444177009776	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
444177009777	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
444177009778	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
444177009779	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
444177009780	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
444177009781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
444177009782	PhoU domain; Region: PhoU; pfam01895
444177009783	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
444177009784	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
444177009785	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
444177009786	PhoU domain; Region: PhoU; pfam01895
444177009787	PhoU domain; Region: PhoU; pfam01895
444177009788	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
444177009789	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
444177009790	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
444177009791	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
444177009792	Uncharacterized conserved protein [Function unknown]; Region: COG5663
444177009793	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
444177009794	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
444177009795	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
444177009796	Domain of unknown function DUF21; Region: DUF21; pfam01595
444177009797	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
444177009798	Transporter associated domain; Region: CorC_HlyC; smart01091
444177009799	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
444177009800	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
444177009801	active site
444177009802	metal binding site [ion binding]; metal-binding site
444177009803	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
444177009804	UbiA prenyltransferase family; Region: UbiA; pfam01040
444177009805	Predicted esterase [General function prediction only]; Region: COG0400
444177009806	putative hydrolase; Provisional; Region: PRK11460
444177009807	TPR repeat; Region: TPR_11; pfam13414
444177009808	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177009809	binding surface
444177009810	TPR motif; other site
444177009811	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
444177009812	catalytic residues [active]
444177009813	Predicted membrane protein [Function unknown]; Region: COG1511
444177009814	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
444177009815	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
444177009816	Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798
444177009817	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
444177009818	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
444177009819	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
444177009820	DXD motif; other site
444177009821	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
444177009822	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
444177009823	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177009824	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177009825	metal binding site [ion binding]; metal-binding site
444177009826	active site
444177009827	I-site; other site
444177009828	Isochorismatase family; Region: Isochorismatase; pfam00857
444177009829	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
444177009830	catalytic triad [active]
444177009831	dimer interface [polypeptide binding]; other site
444177009832	conserved cis-peptide bond; other site
444177009833	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
444177009834	homodimer interface [polypeptide binding]; other site
444177009835	substrate-cofactor binding pocket; other site
444177009836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177009837	catalytic residue [active]
444177009838	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
444177009839	metal binding site 2 [ion binding]; metal-binding site
444177009840	putative DNA binding helix; other site
444177009841	metal binding site 1 [ion binding]; metal-binding site
444177009842	dimer interface [polypeptide binding]; other site
444177009843	structural Zn2+ binding site [ion binding]; other site
444177009844	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
444177009845	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177009846	ABC-ATPase subunit  interface; other site
444177009847	dimer interface [polypeptide binding]; other site
444177009848	putative PBP binding regions; other site
444177009849	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
444177009850	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
444177009851	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
444177009852	endonuclease IV; Provisional; Region: PRK01060
444177009853	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
444177009854	AP (apurinic/apyrimidinic) site pocket; other site
444177009855	DNA interaction; other site
444177009856	Metal-binding active site; metal-binding site
444177009857	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
444177009858	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
444177009859	ATP binding site [chemical binding]; other site
444177009860	Mg++ binding site [ion binding]; other site
444177009861	motif III; other site
444177009862	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177009863	nucleotide binding region [chemical binding]; other site
444177009864	ATP-binding site [chemical binding]; other site
444177009865	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
444177009866	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
444177009867	putative NAD(P) binding site [chemical binding]; other site
444177009868	catalytic Zn binding site [ion binding]; other site
444177009869	K+-transporting ATPase, c chain; Region: KdpC; cl00944
444177009870	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
444177009871	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
444177009872	Soluble P-type ATPase [General function prediction only]; Region: COG4087
444177009873	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
444177009874	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
444177009875	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
444177009876	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
444177009877	Ligand Binding Site [chemical binding]; other site
444177009878	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
444177009879	GAF domain; Region: GAF_3; pfam13492
444177009880	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177009881	dimer interface [polypeptide binding]; other site
444177009882	phosphorylation site [posttranslational modification]
444177009883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177009884	ATP binding site [chemical binding]; other site
444177009885	Mg2+ binding site [ion binding]; other site
444177009886	G-X-G motif; other site
444177009887	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177009888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177009889	active site
444177009890	phosphorylation site [posttranslational modification]
444177009891	intermolecular recognition site; other site
444177009892	dimerization interface [polypeptide binding]; other site
444177009893	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177009894	DNA binding site [nucleotide binding]
444177009895	YqfQ-like protein; Region: YqfQ; pfam14181
444177009896	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
444177009897	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
444177009898	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
444177009899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177009900	active site
444177009901	phosphorylation site [posttranslational modification]
444177009902	intermolecular recognition site; other site
444177009903	dimerization interface [polypeptide binding]; other site
444177009904	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
444177009905	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
444177009906	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177009907	putative active site [active]
444177009908	heme pocket [chemical binding]; other site
444177009909	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177009910	ATP binding site [chemical binding]; other site
444177009911	Mg2+ binding site [ion binding]; other site
444177009912	G-X-G motif; other site
444177009913	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
444177009914	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
444177009915	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
444177009916	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
444177009917	Predicted flavoprotein [General function prediction only]; Region: COG0431
444177009918	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
444177009919	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
444177009920	Uncharacterized conserved protein [Function unknown]; Region: COG0327
444177009921	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
444177009922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
444177009923	Uncharacterized conserved protein [Function unknown]; Region: COG0327
444177009924	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
444177009925	Family of unknown function (DUF633); Region: DUF633; pfam04816
444177009926	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
444177009927	Family of unknown function (DUF633); Region: DUF633; pfam04816
444177009928	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
444177009929	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
444177009930	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
444177009931	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
444177009932	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177009933	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
444177009934	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177009935	DNA binding residues [nucleotide binding]
444177009936	DNA primase; Validated; Region: dnaG; PRK05667
444177009937	CHC2 zinc finger; Region: zf-CHC2; pfam01807
444177009938	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
444177009939	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
444177009940	active site
444177009941	metal binding site [ion binding]; metal-binding site
444177009942	interdomain interaction site; other site
444177009943	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
444177009944	PEP synthetase regulatory protein; Provisional; Region: PRK05339
444177009945	HTH domain; Region: HTH_11; pfam08279
444177009946	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
444177009947	FOG: CBS domain [General function prediction only]; Region: COG0517
444177009948	glycyl-tRNA synthetase; Provisional; Region: PRK04173
444177009949	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
444177009950	motif 1; other site
444177009951	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
444177009952	active site
444177009953	motif 2; other site
444177009954	motif 3; other site
444177009955	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
444177009956	anticodon binding site; other site
444177009957	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
444177009958	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177009959	Zn2+ binding site [ion binding]; other site
444177009960	Mg2+ binding site [ion binding]; other site
444177009961	S-layer homology domain; Region: SLH; pfam00395
444177009962	S-layer homology domain; Region: SLH; pfam00395
444177009963	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
444177009964	Recombination protein O N terminal; Region: RecO_N; pfam11967
444177009965	Recombination protein O C terminal; Region: RecO_C; pfam02565
444177009966	GTPase Era; Reviewed; Region: era; PRK00089
444177009967	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
444177009968	G1 box; other site
444177009969	GTP/Mg2+ binding site [chemical binding]; other site
444177009970	Switch I region; other site
444177009971	G2 box; other site
444177009972	Switch II region; other site
444177009973	G3 box; other site
444177009974	G4 box; other site
444177009975	G5 box; other site
444177009976	KH domain; Region: KH_2; pfam07650
444177009977	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
444177009978	catalytic motif [active]
444177009979	Zn binding site [ion binding]; other site
444177009980	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
444177009981	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
444177009982	metal-binding heat shock protein; Provisional; Region: PRK00016
444177009983	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
444177009984	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
444177009985	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177009986	Zn2+ binding site [ion binding]; other site
444177009987	Mg2+ binding site [ion binding]; other site
444177009988	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
444177009989	PhoH-like protein; Region: PhoH; pfam02562
444177009990	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
444177009991	hypothetical protein; Provisional; Region: PRK13665
444177009992	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
444177009993	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
444177009994	dimer interface [polypeptide binding]; other site
444177009995	active site residues [active]
444177009996	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
444177009997	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
444177009998	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
444177009999	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
444177010000	TrkA-N domain; Region: TrkA_N; pfam02254
444177010001	TrkA-C domain; Region: TrkA_C; pfam02080
444177010002	Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546
444177010003	dinuclear metal binding motif [ion binding]; other site
444177010004	CotJB protein; Region: CotJB; pfam12652
444177010005	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
444177010006	intersubunit interface [polypeptide binding]; other site
444177010007	active site
444177010008	catalytic residue [active]
444177010009	Replication-relaxation; Region: Replic_Relax; pfam13814
444177010010	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
444177010011	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177010012	non-specific DNA binding site [nucleotide binding]; other site
444177010013	salt bridge; other site
444177010014	sequence-specific DNA binding site [nucleotide binding]; other site
444177010015	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
444177010016	amidase catalytic site [active]
444177010017	Zn binding residues [ion binding]; other site
444177010018	substrate binding site [chemical binding]; other site
444177010019	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177010020	Holin family; Region: Phage_holin_4; cl01989
444177010021	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
444177010022	cofactor binding site; other site
444177010023	DNA binding site [nucleotide binding]
444177010024	substrate interaction site [chemical binding]; other site
444177010025	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
444177010026	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
444177010027	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
444177010028	Baseplate J-like protein; Region: Baseplate_J; cl01294
444177010029	Baseplate J-like protein; Region: Baseplate_J; pfam04865
444177010030	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
444177010031	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
444177010032	Bacterial SH3 domain; Region: SH3_3; pfam08239
444177010033	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
444177010034	Acetokinase family; Region: Acetate_kinase; cl17229
444177010035	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
444177010036	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
444177010037	Phage tail tube protein FII; Region: Phage_tube; cl01390
444177010038	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
444177010039	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094
444177010040	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
444177010041	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
444177010042	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
444177010043	oligomer interface [polypeptide binding]; other site
444177010044	active site residues [active]
444177010045	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
444177010046	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
444177010047	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177010048	active site
444177010049	DNA binding site [nucleotide binding]
444177010050	Int/Topo IB signature motif; other site
444177010051	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
444177010052	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
444177010053	Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298
444177010054	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
444177010055	PcfJ-like protein; Region: PcfJ; pfam14284
444177010056	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
444177010057	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
444177010058	catalytic residues [active]
444177010059	catalytic nucleophile [active]
444177010060	Recombinase; Region: Recombinase; pfam07508
444177010061	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
444177010062	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
444177010063	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
444177010064	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177010065	FeS/SAM binding site; other site
444177010066	TRAM domain; Region: TRAM; cl01282
444177010067	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
444177010068	RNA methyltransferase, RsmE family; Region: TIGR00046
444177010069	chaperone protein DnaJ; Provisional; Region: PRK14280
444177010070	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
444177010071	HSP70 interaction site [polypeptide binding]; other site
444177010072	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
444177010073	substrate binding site [polypeptide binding]; other site
444177010074	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
444177010075	Zn binding sites [ion binding]; other site
444177010076	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
444177010077	dimer interface [polypeptide binding]; other site
444177010078	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
444177010079	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
444177010080	nucleotide binding site [chemical binding]; other site
444177010081	NEF interaction site [polypeptide binding]; other site
444177010082	SBD interface [polypeptide binding]; other site
444177010083	heat shock protein GrpE; Provisional; Region: PRK14140
444177010084	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
444177010085	dimer interface [polypeptide binding]; other site
444177010086	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
444177010087	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
444177010088	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
444177010089	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
444177010090	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
444177010091	FeS/SAM binding site; other site
444177010092	HemN C-terminal domain; Region: HemN_C; pfam06969
444177010093	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
444177010094	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
444177010095	Chromate transporter; Region: Chromate_transp; pfam02417
444177010096	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
444177010097	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
444177010098	DHH family; Region: DHH; pfam01368
444177010099	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
444177010100	Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956
444177010101	NodB motif; other site
444177010102	putative active site [active]
444177010103	putative catalytic site [active]
444177010104	putative Zn binding site [ion binding]; other site
444177010105	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
444177010106	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177010107	catalytic residue [active]
444177010108	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177010109	dimerization interface [polypeptide binding]; other site
444177010110	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177010111	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177010112	dimer interface [polypeptide binding]; other site
444177010113	putative CheW interface [polypeptide binding]; other site
444177010114	Yqey-like protein; Region: YqeY; cl17540
444177010115	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
444177010116	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
444177010117	NADP binding site [chemical binding]; other site
444177010118	dimer interface [polypeptide binding]; other site
444177010119	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
444177010120	active site
444177010121	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
444177010122	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177010123	Coenzyme A binding pocket [chemical binding]; other site
444177010124	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177010125	Coenzyme A binding pocket [chemical binding]; other site
444177010126	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
444177010127	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
444177010128	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
444177010129	BclB C-terminal domain; Region: exospore_TM; TIGR03721
444177010130	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
444177010131	GTP-binding protein LepA; Provisional; Region: PRK05433
444177010132	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
444177010133	G1 box; other site
444177010134	putative GEF interaction site [polypeptide binding]; other site
444177010135	GTP/Mg2+ binding site [chemical binding]; other site
444177010136	Switch I region; other site
444177010137	G2 box; other site
444177010138	G3 box; other site
444177010139	Switch II region; other site
444177010140	G4 box; other site
444177010141	G5 box; other site
444177010142	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
444177010143	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
444177010144	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
444177010145	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
444177010146	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
444177010147	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
444177010148	catalytic triad [active]
444177010149	catalytic triad [active]
444177010150	oxyanion hole [active]
444177010151	stage II sporulation protein P; Region: spore_II_P; TIGR02867
444177010152	germination protease; Provisional; Region: PRK02858
444177010153	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
444177010154	Transposase domain (DUF772); Region: DUF772; pfam05598
444177010155	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
444177010156	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
444177010157	YqzM-like protein; Region: YqzM; pfam14141
444177010158	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
444177010159	Competence protein; Region: Competence; pfam03772
444177010160	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
444177010161	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177010162	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
444177010163	catalytic motif [active]
444177010164	Zn binding site [ion binding]; other site
444177010165	SLBB domain; Region: SLBB; pfam10531
444177010166	comEA protein; Region: comE; TIGR01259
444177010167	Helix-hairpin-helix motif; Region: HHH; pfam00633
444177010168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177010169	S-adenosylmethionine binding site [chemical binding]; other site
444177010170	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
444177010171	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177010172	Zn2+ binding site [ion binding]; other site
444177010173	Mg2+ binding site [ion binding]; other site
444177010174	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
444177010175	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
444177010176	active site
444177010177	(T/H)XGH motif; other site
444177010178	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
444177010179	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
444177010180	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
444177010181	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
444177010182	shikimate binding site; other site
444177010183	NAD(P) binding site [chemical binding]; other site
444177010184	GTPase YqeH; Provisional; Region: PRK13796
444177010185	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
444177010186	GTP/Mg2+ binding site [chemical binding]; other site
444177010187	G4 box; other site
444177010188	G5 box; other site
444177010189	G1 box; other site
444177010190	Switch I region; other site
444177010191	G2 box; other site
444177010192	G3 box; other site
444177010193	Switch II region; other site
444177010194	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
444177010195	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177010196	active site
444177010197	motif I; other site
444177010198	motif II; other site
444177010199	phosphatidylserine decarboxylase; Provisional; Region: PRK03140
444177010200	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
444177010201	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
444177010202	sporulation sigma factor SigK; Reviewed; Region: PRK05803
444177010203	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177010204	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177010205	DNA binding residues [nucleotide binding]
444177010206	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
444177010207	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
444177010208	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
444177010209	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
444177010210	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
444177010211	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
444177010212	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
444177010213	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
444177010214	ATP-binding site [chemical binding]; other site
444177010215	Sugar specificity; other site
444177010216	Pyrimidine base specificity; other site
444177010217	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
444177010218	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
444177010219	Peptidase family U32; Region: Peptidase_U32; pfam01136
444177010220	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
444177010221	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
444177010222	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177010223	S-adenosylmethionine binding site [chemical binding]; other site
444177010224	YceG-like family; Region: YceG; pfam02618
444177010225	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
444177010226	dimerization interface [polypeptide binding]; other site
444177010227	hypothetical protein; Provisional; Region: PRK13678
444177010228	hypothetical protein; Provisional; Region: PRK13678
444177010229	hypothetical protein; Provisional; Region: PRK13678
444177010230	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
444177010231	hypothetical protein; Provisional; Region: PRK05473
444177010232	DHHA1 domain; Region: DHHA1; pfam02272
444177010233	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
444177010234	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
444177010235	motif 1; other site
444177010236	active site
444177010237	motif 2; other site
444177010238	motif 3; other site
444177010239	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
444177010240	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
444177010241	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
444177010242	oligomer interface [polypeptide binding]; other site
444177010243	metal binding site [ion binding]; metal-binding site
444177010244	metal binding site [ion binding]; metal-binding site
444177010245	putative Cl binding site [ion binding]; other site
444177010246	aspartate ring; other site
444177010247	basic sphincter; other site
444177010248	hydrophobic gate; other site
444177010249	periplasmic entrance; other site
444177010250	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309
444177010251	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
444177010252	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
444177010253	AAA domain; Region: AAA_30; pfam13604
444177010254	Family description; Region: UvrD_C_2; pfam13538
444177010255	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
444177010256	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
444177010257	active site
444177010258	hypothetical protein; Provisional; Region: PRK04435
444177010259	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
444177010260	synthetase active site [active]
444177010261	NTP binding site [chemical binding]; other site
444177010262	metal binding site [ion binding]; metal-binding site
444177010263	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177010264	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177010265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177010266	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177010267	binding surface
444177010268	TPR repeat; Region: TPR_11; pfam13414
444177010269	TPR motif; other site
444177010270	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177010271	Tetratricopeptide repeat; Region: TPR_12; pfam13424
444177010272	TPR motif; other site
444177010273	binding surface
444177010274	TPR repeat; Region: TPR_11; pfam13414
444177010275	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
444177010276	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
444177010277	Predicted transcriptional regulator [Transcription]; Region: COG1959
444177010278	Transcriptional regulator; Region: Rrf2; pfam02082
444177010279	recombination factor protein RarA; Reviewed; Region: PRK13342
444177010280	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177010281	Walker A motif; other site
444177010282	ATP binding site [chemical binding]; other site
444177010283	Walker B motif; other site
444177010284	arginine finger; other site
444177010285	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
444177010286	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
444177010287	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
444177010288	putative ATP binding site [chemical binding]; other site
444177010289	putative substrate interface [chemical binding]; other site
444177010290	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
444177010291	nucleotide binding site [chemical binding]; other site
444177010292	Uncharacterized conserved protein [Function unknown]; Region: COG3589
444177010293	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
444177010294	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
444177010295	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
444177010296	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
444177010297	methionine cluster; other site
444177010298	active site
444177010299	phosphorylation site [posttranslational modification]
444177010300	metal binding site [ion binding]; metal-binding site
444177010301	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
444177010302	active site
444177010303	P-loop; other site
444177010304	phosphorylation site [posttranslational modification]
444177010305	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
444177010306	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177010307	Coenzyme A binding pocket [chemical binding]; other site
444177010308	Sterol carrier protein domain; Region: SCP2_2; pfam13530
444177010309	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
444177010310	regulatory protein interface [polypeptide binding]; other site
444177010311	active site
444177010312	regulatory phosphorylation site [posttranslational modification]; other site
444177010313	hypothetical protein; Provisional; Region: PRK02947
444177010314	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
444177010315	putative active site [active]
444177010316	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
444177010317	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177010318	DNA-binding site [nucleotide binding]; DNA binding site
444177010319	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
444177010320	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
444177010321	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
444177010322	dimer interface [polypeptide binding]; other site
444177010323	anticodon binding site; other site
444177010324	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
444177010325	homodimer interface [polypeptide binding]; other site
444177010326	motif 1; other site
444177010327	active site
444177010328	motif 2; other site
444177010329	GAD domain; Region: GAD; pfam02938
444177010330	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
444177010331	motif 3; other site
444177010332	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
444177010333	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
444177010334	dimer interface [polypeptide binding]; other site
444177010335	motif 1; other site
444177010336	active site
444177010337	motif 2; other site
444177010338	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
444177010339	anticodon binding site; other site
444177010340	Bacterial SH3 domain; Region: SH3_3; pfam08239
444177010341	Bacterial SH3 domain; Region: SH3_3; pfam08239
444177010342	Bacterial SH3 domain; Region: SH3_3; pfam08239
444177010343	Bacterial SH3 domain; Region: SH3_3; pfam08239
444177010344	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
444177010345	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
444177010346	active site
444177010347	metal binding site [ion binding]; metal-binding site
444177010348	Predicted membrane protein [Function unknown]; Region: COG1288
444177010349	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
444177010350	Predicted transcriptional regulator [Transcription]; Region: COG3355
444177010351	Protein of unknown function (DUF2642); Region: DUF2642; pfam10842
444177010352	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
444177010353	putative active site [active]
444177010354	dimerization interface [polypeptide binding]; other site
444177010355	putative tRNAtyr binding site [nucleotide binding]; other site
444177010356	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
444177010357	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177010358	Zn2+ binding site [ion binding]; other site
444177010359	Mg2+ binding site [ion binding]; other site
444177010360	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
444177010361	synthetase active site [active]
444177010362	NTP binding site [chemical binding]; other site
444177010363	metal binding site [ion binding]; metal-binding site
444177010364	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
444177010365	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
444177010366	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
444177010367	putative kinase; Provisional; Region: PRK09954
444177010368	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
444177010369	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
444177010370	substrate binding site [chemical binding]; other site
444177010371	ATP binding site [chemical binding]; other site
444177010372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177010373	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177010374	putative substrate translocation pore; other site
444177010375	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177010376	MarR family; Region: MarR_2; pfam12802
444177010377	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
444177010378	active site
444177010379	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
444177010380	DHH family; Region: DHH; pfam01368
444177010381	DHHA1 domain; Region: DHHA1; pfam02272
444177010382	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
444177010383	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
444177010384	phosphate binding site [ion binding]; other site
444177010385	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
444177010386	substrate binding site [chemical binding]; other site
444177010387	active site
444177010388	catalytic residues [active]
444177010389	heterodimer interface [polypeptide binding]; other site
444177010390	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
444177010391	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
444177010392	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177010393	catalytic residue [active]
444177010394	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
444177010395	active site
444177010396	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
444177010397	active site
444177010398	ribulose/triose binding site [chemical binding]; other site
444177010399	phosphate binding site [ion binding]; other site
444177010400	substrate (anthranilate) binding pocket [chemical binding]; other site
444177010401	product (indole) binding pocket [chemical binding]; other site
444177010402	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
444177010403	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
444177010404	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
444177010405	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
444177010406	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
444177010407	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177010408	dimerization interface [polypeptide binding]; other site
444177010409	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177010410	dimer interface [polypeptide binding]; other site
444177010411	putative CheW interface [polypeptide binding]; other site
444177010412	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
444177010413	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
444177010414	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
444177010415	Protein export membrane protein; Region: SecD_SecF; pfam02355
444177010416	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
444177010417	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
444177010418	Predicted membrane protein [Function unknown]; Region: COG2323
444177010419	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
444177010420	putative active site [active]
444177010421	putative metal binding site [ion binding]; other site
444177010422	Preprotein translocase subunit; Region: YajC; pfam02699
444177010423	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
444177010424	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
444177010425	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
444177010426	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
444177010427	Holliday junction DNA helicase ruvB N-terminus; Region: RuvB_N; pfam05496
444177010428	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
444177010429	RuvA N terminal domain; Region: RuvA_N; pfam01330
444177010430	Phosphotransferase enzyme family; Region: APH; pfam01636
444177010431	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
444177010432	substrate binding site [chemical binding]; other site
444177010433	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177010434	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
444177010435	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
444177010436	HTH domain; Region: HTH_11; pfam08279
444177010437	3H domain; Region: 3H; pfam02829
444177010438	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
444177010439	prephenate dehydratase; Provisional; Region: PRK11898
444177010440	Prephenate dehydratase; Region: PDT; pfam00800
444177010441	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
444177010442	putative L-Phe binding site [chemical binding]; other site
444177010443	hypothetical protein; Provisional; Region: PRK04435
444177010444	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
444177010445	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
444177010446	G4 box; other site
444177010447	G5 box; other site
444177010448	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
444177010449	GTPase CgtA; Reviewed; Region: obgE; PRK12297
444177010450	GTP1/OBG; Region: GTP1_OBG; pfam01018
444177010451	Obg GTPase; Region: Obg; cd01898
444177010452	G1 box; other site
444177010453	GTP/Mg2+ binding site [chemical binding]; other site
444177010454	Switch I region; other site
444177010455	G2 box; other site
444177010456	G3 box; other site
444177010457	Switch II region; other site
444177010458	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
444177010459	Protein of unknown function (DUF464); Region: DUF464; pfam04327
444177010460	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
444177010461	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
444177010462	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
444177010463	putative substrate binding region [chemical binding]; other site
444177010464	Peptidase family M23; Region: Peptidase_M23; pfam01551
444177010465	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
444177010466	active site
444177010467	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
444177010468	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
444177010469	Switch I; other site
444177010470	Switch II; other site
444177010471	septum formation inhibitor; Reviewed; Region: minC; PRK00513
444177010472	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
444177010473	rod shape-determining protein MreD; Region: MreD; cl01087
444177010474	rod shape-determining protein MreC; Provisional; Region: PRK13922
444177010475	rod shape-determining protein MreC; Region: MreC; pfam04085
444177010476	rod shape-determining protein MreB; Provisional; Region: PRK13927
444177010477	MreB and similar proteins; Region: MreB_like; cd10225
444177010478	nucleotide binding site [chemical binding]; other site
444177010479	Mg binding site [ion binding]; other site
444177010480	putative protofilament interaction site [polypeptide binding]; other site
444177010481	RodZ interaction site [polypeptide binding]; other site
444177010482	hypothetical protein; Reviewed; Region: PRK00024
444177010483	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
444177010484	MPN+ (JAMM) motif; other site
444177010485	Zinc-binding site [ion binding]; other site
444177010486	Maf-like protein; Region: Maf; pfam02545
444177010487	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
444177010488	active site
444177010489	dimer interface [polypeptide binding]; other site
444177010490	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
444177010491	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
444177010492	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
444177010493	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
444177010494	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
444177010495	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
444177010496	active site
444177010497	HIGH motif; other site
444177010498	nucleotide binding site [chemical binding]; other site
444177010499	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
444177010500	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
444177010501	active site
444177010502	KMSKS motif; other site
444177010503	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
444177010504	tRNA binding surface [nucleotide binding]; other site
444177010505	anticodon binding site; other site
444177010506	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
444177010507	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
444177010508	hydrophobic ligand binding site; other site
444177010509	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
444177010510	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
444177010511	inhibitor-cofactor binding pocket; inhibition site
444177010512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177010513	catalytic residue [active]
444177010514	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
444177010515	dimer interface [polypeptide binding]; other site
444177010516	active site
444177010517	Schiff base residues; other site
444177010518	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
444177010519	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
444177010520	active site
444177010521	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
444177010522	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
444177010523	domain interfaces; other site
444177010524	active site
444177010525	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
444177010526	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
444177010527	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
444177010528	tRNA; other site
444177010529	putative tRNA binding site [nucleotide binding]; other site
444177010530	putative NADP binding site [chemical binding]; other site
444177010531	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
444177010532	S-layer homology domain; Region: SLH; pfam00395
444177010533	von Willebrand factor type A domain; Region: VWA_2; pfam13519
444177010534	metal ion-dependent adhesion site (MIDAS); other site
444177010535	S-layer homology domain; Region: SLH; pfam00395
444177010536	S-layer homology domain; Region: SLH; pfam00395
444177010537	Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318
444177010538	Putative motility protein; Region: YjfB_motility; pfam14070
444177010539	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
444177010540	G1 box; other site
444177010541	GTP/Mg2+ binding site [chemical binding]; other site
444177010542	Switch I region; other site
444177010543	G2 box; other site
444177010544	G3 box; other site
444177010545	Switch II region; other site
444177010546	G4 box; other site
444177010547	G5 box; other site
444177010548	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
444177010549	Found in ATP-dependent protease La (LON); Region: LON; smart00464
444177010550	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177010551	Walker A motif; other site
444177010552	ATP binding site [chemical binding]; other site
444177010553	Walker B motif; other site
444177010554	arginine finger; other site
444177010555	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
444177010556	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
444177010557	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
444177010558	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177010559	Walker A motif; other site
444177010560	ATP binding site [chemical binding]; other site
444177010561	Walker B motif; other site
444177010562	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
444177010563	trigger factor; Provisional; Region: tig; PRK01490
444177010564	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
444177010565	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
444177010566	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
444177010567	binding surface
444177010568	TPR motif; other site
444177010569	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
444177010570	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
444177010571	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
444177010572	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
444177010573	cytochrome aa3 quinol oxidase, subunit I; Region: QoxB; TIGR02882
444177010574	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
444177010575	cytochrome aa3 quinol oxidase, subunit I; Region: QoxB; TIGR02882
444177010576	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
444177010577	Subunit I/III interface [polypeptide binding]; other site
444177010578	Subunit III/IV interface [polypeptide binding]; other site
444177010579	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
444177010580	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
444177010581	Ligand Binding Site [chemical binding]; other site
444177010582	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
444177010583	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
444177010584	YugN-like family; Region: YugN; pfam08868
444177010585	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
444177010586	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
444177010587	Spore germination protein; Region: Spore_permease; pfam03845
444177010588	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
444177010589	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
444177010590	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
444177010591	Beta-lactamase; Region: Beta-lactamase; pfam00144
444177010592	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
444177010593	nudix motif; other site
444177010594	DinB superfamily; Region: DinB_2; pfam12867
444177010595	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
444177010596	DinB family; Region: DinB; cl17821
444177010597	DinB superfamily; Region: DinB_2; pfam12867
444177010598	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
444177010599	Sulfatase; Region: Sulfatase; cl17466
444177010600	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
444177010601	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177010602	active site
444177010603	phosphorylation site [posttranslational modification]
444177010604	intermolecular recognition site; other site
444177010605	dimerization interface [polypeptide binding]; other site
444177010606	LytTr DNA-binding domain; Region: LytTR; pfam04397
444177010607	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
444177010608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177010609	ATP binding site [chemical binding]; other site
444177010610	Mg2+ binding site [ion binding]; other site
444177010611	G-X-G motif; other site
444177010612	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
444177010613	Accessory gene regulator B; Region: AgrB; pfam04647
444177010614	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
444177010615	NADPH bind site [chemical binding]; other site
444177010616	putative FMN binding site [chemical binding]; other site
444177010617	SpaB C-terminal domain; Region: SpaB_C; pfam14028
444177010618	YcaO-like family; Region: YcaO; pfam02624
444177010619	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
444177010620	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
444177010621	ABC-2 type transporter; Region: ABC2_membrane; cl17235
444177010622	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
444177010623	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
444177010624	Walker A/P-loop; other site
444177010625	ATP binding site [chemical binding]; other site
444177010626	Q-loop/lid; other site
444177010627	ABC transporter signature motif; other site
444177010628	Walker B; other site
444177010629	D-loop; other site
444177010630	H-loop/switch region; other site
444177010631	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
444177010632	aconitate hydratase 1; Region: aconitase_1; TIGR01341
444177010633	Predicted membrane protein [Function unknown]; Region: COG2323
444177010634	Integrase core domain; Region: rve; pfam00665
444177010635	Integrase core domain; Region: rve_2; pfam13333
444177010636	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
444177010637	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
444177010638	putative active site [active]
444177010639	putative NTP binding site [chemical binding]; other site
444177010640	putative nucleic acid binding site [nucleotide binding]; other site
444177010641	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
444177010642	active site
444177010643	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
444177010644	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177010645	NAD(P) binding site [chemical binding]; other site
444177010646	active site
444177010647	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
444177010648	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
444177010649	Uncharacterized conserved protein [Function unknown]; Region: COG0397
444177010650	hypothetical protein; Validated; Region: PRK00029
444177010651	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
444177010652	active site
444177010653	metal binding site [ion binding]; metal-binding site
444177010654	homotetramer interface [polypeptide binding]; other site
444177010655	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
444177010656	active site
444177010657	dimerization interface [polypeptide binding]; other site
444177010658	ribonuclease PH; Reviewed; Region: rph; PRK00173
444177010659	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
444177010660	RNA binding site [nucleotide binding]; other site
444177010661	oligomer interface [polypeptide binding]; other site
444177010662	glutamate racemase; Provisional; Region: PRK00865
444177010663	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
444177010664	MarR family; Region: MarR; pfam01047
444177010665	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177010666	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
444177010667	DNA binding residues [nucleotide binding]
444177010668	dimerization interface [polypeptide binding]; other site
444177010669	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
444177010670	active site
444177010671	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
444177010672	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
444177010673	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
444177010674	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
444177010675	L-aspartate oxidase; Provisional; Region: PRK06175
444177010676	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
444177010677	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
444177010678	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
444177010679	putative Iron-sulfur protein interface [polypeptide binding]; other site
444177010680	proximal heme binding site [chemical binding]; other site
444177010681	distal heme binding site [chemical binding]; other site
444177010682	putative dimer interface [polypeptide binding]; other site
444177010683	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
444177010684	aspartate kinase; Reviewed; Region: PRK06635
444177010685	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
444177010686	nucleotide binding site [chemical binding]; other site
444177010687	substrate binding site [chemical binding]; other site
444177010688	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
444177010689	putative allosteric regulatory site; other site
444177010690	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
444177010691	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
444177010692	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
444177010693	GIY-YIG motif/motif A; other site
444177010694	active site
444177010695	catalytic site [active]
444177010696	putative DNA binding site [nucleotide binding]; other site
444177010697	metal binding site [ion binding]; metal-binding site
444177010698	UvrB/uvrC motif; Region: UVR; pfam02151
444177010699	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
444177010700	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
444177010701	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
444177010702	catalytic residues [active]
444177010703	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
444177010704	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
444177010705	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
444177010706	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
444177010707	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
444177010708	Ligand binding site [chemical binding]; other site
444177010709	Electron transfer flavoprotein domain; Region: ETF; pfam01012
444177010710	enoyl-CoA hydratase; Provisional; Region: PRK07658
444177010711	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
444177010712	substrate binding site [chemical binding]; other site
444177010713	oxyanion hole (OAH) forming residues; other site
444177010714	trimer interface [polypeptide binding]; other site
444177010715	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
444177010716	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177010717	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177010718	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
444177010719	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
444177010720	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
444177010721	acyl-activating enzyme (AAE) consensus motif; other site
444177010722	putative AMP binding site [chemical binding]; other site
444177010723	putative active site [active]
444177010724	putative CoA binding site [chemical binding]; other site
444177010725	Predicted membrane protein [Function unknown]; Region: COG3766
444177010726	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
444177010727	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
444177010728	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
444177010729	MutS domain III; Region: MutS_III; pfam05192
444177010730	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
444177010731	Walker A/P-loop; other site
444177010732	ATP binding site [chemical binding]; other site
444177010733	Q-loop/lid; other site
444177010734	ABC transporter signature motif; other site
444177010735	Walker B; other site
444177010736	D-loop; other site
444177010737	H-loop/switch region; other site
444177010738	Smr domain; Region: Smr; pfam01713
444177010739	hypothetical protein; Provisional; Region: PRK08609
444177010740	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
444177010741	active site
444177010742	primer binding site [nucleotide binding]; other site
444177010743	NTP  binding site [chemical binding]; other site
444177010744	metal binding triad [ion binding]; metal-binding site
444177010745	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
444177010746	active site
444177010747	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
444177010748	Colicin V production protein; Region: Colicin_V; pfam02674
444177010749	Cell division protein ZapA; Region: ZapA; cl01146
444177010750	ribonuclease HIII; Provisional; Region: PRK00996
444177010751	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
444177010752	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
444177010753	RNA/DNA hybrid binding site [nucleotide binding]; other site
444177010754	active site
444177010755	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
444177010756	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
444177010757	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
444177010758	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
444177010759	putative tRNA-binding site [nucleotide binding]; other site
444177010760	B3/4 domain; Region: B3_4; pfam03483
444177010761	tRNA synthetase B5 domain; Region: B5; smart00874
444177010762	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
444177010763	dimer interface [polypeptide binding]; other site
444177010764	motif 1; other site
444177010765	motif 3; other site
444177010766	motif 2; other site
444177010767	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
444177010768	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
444177010769	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
444177010770	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
444177010771	dimer interface [polypeptide binding]; other site
444177010772	motif 1; other site
444177010773	active site
444177010774	motif 2; other site
444177010775	motif 3; other site
444177010776	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
444177010777	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
444177010778	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
444177010779	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
444177010780	active site
444177010781	8-oxo-dGMP binding site [chemical binding]; other site
444177010782	nudix motif; other site
444177010783	metal binding site [ion binding]; metal-binding site
444177010784	PAS domain; Region: PAS_9; pfam13426
444177010785	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177010786	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177010787	metal binding site [ion binding]; metal-binding site
444177010788	active site
444177010789	I-site; other site
444177010790	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
444177010791	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
444177010792	catalytic site [active]
444177010793	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
444177010794	FAD binding domain; Region: FAD_binding_4; pfam01565
444177010795	Berberine and berberine like; Region: BBE; pfam08031
444177010796	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
444177010797	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177010798	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177010799	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177010800	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
444177010801	active site
444177010802	Small acid-soluble spore protein H family; Region: SspH; pfam08141
444177010803	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
444177010804	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177010805	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177010806	metal binding site [ion binding]; metal-binding site
444177010807	active site
444177010808	I-site; other site
444177010809	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
444177010810	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
444177010811	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
444177010812	DNA binding residues [nucleotide binding]
444177010813	small acid-soluble spore protein SspI; Provisional; Region: PRK02955
444177010814	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
444177010815	FAD binding domain; Region: FAD_binding_4; pfam01565
444177010816	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
444177010817	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177010818	Coenzyme A binding pocket [chemical binding]; other site
444177010819	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177010820	dimer interface [polypeptide binding]; other site
444177010821	conserved gate region; other site
444177010822	putative PBP binding loops; other site
444177010823	ABC-ATPase subunit interface; other site
444177010824	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
444177010825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177010826	dimer interface [polypeptide binding]; other site
444177010827	conserved gate region; other site
444177010828	putative PBP binding loops; other site
444177010829	ABC-ATPase subunit interface; other site
444177010830	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
444177010831	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
444177010832	substrate binding pocket [chemical binding]; other site
444177010833	membrane-bound complex binding site; other site
444177010834	hinge residues; other site
444177010835	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
444177010836	catalytic residues [active]
444177010837	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
444177010838	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
444177010839	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
444177010840	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
444177010841	active site
444177010842	non-prolyl cis peptide bond; other site
444177010843	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177010844	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177010845	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
444177010846	dimerization interface [polypeptide binding]; other site
444177010847	ornithine carbamoyltransferase; Provisional; Region: PRK00779
444177010848	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
444177010849	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
444177010850	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
444177010851	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
444177010852	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
444177010853	oligomer interface [polypeptide binding]; other site
444177010854	active site
444177010855	metal binding site [ion binding]; metal-binding site
444177010856	dUTPase; Region: dUTPase_2; pfam08761
444177010857	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
444177010858	active site
444177010859	homodimer interface [polypeptide binding]; other site
444177010860	metal binding site [ion binding]; metal-binding site
444177010861	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
444177010862	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
444177010863	23S rRNA binding site [nucleotide binding]; other site
444177010864	L21 binding site [polypeptide binding]; other site
444177010865	L13 binding site [polypeptide binding]; other site
444177010866	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
444177010867	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
444177010868	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
444177010869	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
444177010870	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
444177010871	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
444177010872	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
444177010873	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
444177010874	active site
444177010875	dimer interface [polypeptide binding]; other site
444177010876	motif 1; other site
444177010877	motif 2; other site
444177010878	motif 3; other site
444177010879	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
444177010880	anticodon binding site; other site
444177010881	primosomal protein DnaI; Reviewed; Region: PRK08939
444177010882	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
444177010883	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177010884	Walker A motif; other site
444177010885	ATP binding site [chemical binding]; other site
444177010886	Walker B motif; other site
444177010887	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
444177010888	ATP cone domain; Region: ATP-cone; pfam03477
444177010889	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
444177010890	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
444177010891	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
444177010892	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
444177010893	CoA-binding site [chemical binding]; other site
444177010894	ATP-binding [chemical binding]; other site
444177010895	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
444177010896	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
444177010897	DNA binding site [nucleotide binding]
444177010898	catalytic residue [active]
444177010899	H2TH interface [polypeptide binding]; other site
444177010900	putative catalytic residues [active]
444177010901	turnover-facilitating residue; other site
444177010902	intercalation triad [nucleotide binding]; other site
444177010903	8OG recognition residue [nucleotide binding]; other site
444177010904	putative reading head residues; other site
444177010905	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
444177010906	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
444177010907	DNA polymerase I; Provisional; Region: PRK05755
444177010908	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
444177010909	active site
444177010910	metal binding site 1 [ion binding]; metal-binding site
444177010911	putative 5' ssDNA interaction site; other site
444177010912	metal binding site 3; metal-binding site
444177010913	metal binding site 2 [ion binding]; metal-binding site
444177010914	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
444177010915	putative DNA binding site [nucleotide binding]; other site
444177010916	putative metal binding site [ion binding]; other site
444177010917	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
444177010918	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
444177010919	active site
444177010920	DNA binding site [nucleotide binding]
444177010921	catalytic site [active]
444177010922	HflC protein; Region: hflC; TIGR01932
444177010923	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
444177010924	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
444177010925	HflK protein; Region: hflK; TIGR01933
444177010926	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
444177010927	holin-like protein; Validated; Region: PRK01658
444177010928	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
444177010929	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177010930	dimer interface [polypeptide binding]; other site
444177010931	phosphorylation site [posttranslational modification]
444177010932	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177010933	ATP binding site [chemical binding]; other site
444177010934	Mg2+ binding site [ion binding]; other site
444177010935	G-X-G motif; other site
444177010936	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177010937	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177010938	active site
444177010939	phosphorylation site [posttranslational modification]
444177010940	intermolecular recognition site; other site
444177010941	dimerization interface [polypeptide binding]; other site
444177010942	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177010943	DNA binding site [nucleotide binding]
444177010944	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
444177010945	active site 2 [active]
444177010946	active site 1 [active]
444177010947	malate dehydrogenase; Reviewed; Region: PRK06223
444177010948	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
444177010949	NAD(P) binding site [chemical binding]; other site
444177010950	dimer interface [polypeptide binding]; other site
444177010951	tetramer (dimer of dimers) interface [polypeptide binding]; other site
444177010952	substrate binding site [chemical binding]; other site
444177010953	isocitrate dehydrogenase; Reviewed; Region: PRK07006
444177010954	isocitrate dehydrogenase; Validated; Region: PRK07362
444177010955	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
444177010956	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
444177010957	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
444177010958	domain interfaces; other site
444177010959	active site
444177010960	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
444177010961	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
444177010962	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
444177010963	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
444177010964	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
444177010965	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
444177010966	Transcriptional regulators [Transcription]; Region: FadR; COG2186
444177010967	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177010968	DNA-binding site [nucleotide binding]; DNA binding site
444177010969	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
444177010970	active site
444177010971	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
444177010972	Head binding; Region: Head_binding; pfam09008
444177010973	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
444177010974	generic binding surface II; other site
444177010975	generic binding surface I; other site
444177010976	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
444177010977	DHH family; Region: DHH; pfam01368
444177010978	DHHA1 domain; Region: DHHA1; pfam02272
444177010979	YtpI-like protein; Region: YtpI; pfam14007
444177010980	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
444177010981	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
444177010982	DNA-binding site [nucleotide binding]; DNA binding site
444177010983	DRTGG domain; Region: DRTGG; pfam07085
444177010984	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
444177010985	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
444177010986	active site 2 [active]
444177010987	active site 1 [active]
444177010988	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
444177010989	metal-dependent hydrolase; Provisional; Region: PRK00685
444177010990	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
444177010991	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
444177010992	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
444177010993	active site
444177010994	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
444177010995	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
444177010996	hexamer interface [polypeptide binding]; other site
444177010997	ligand binding site [chemical binding]; other site
444177010998	putative active site [active]
444177010999	NAD(P) binding site [chemical binding]; other site
444177011000	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
444177011001	Ligand Binding Site [chemical binding]; other site
444177011002	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
444177011003	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177011004	S-adenosylmethionine binding site [chemical binding]; other site
444177011005	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
444177011006	dimer interface [polypeptide binding]; other site
444177011007	catalytic triad [active]
444177011008	peroxidatic and resolving cysteines [active]
444177011009	RDD family; Region: RDD; pfam06271
444177011010	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
444177011011	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
444177011012	tandem repeat interface [polypeptide binding]; other site
444177011013	oligomer interface [polypeptide binding]; other site
444177011014	active site residues [active]
444177011015	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
444177011016	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
444177011017	acyl-activating enzyme (AAE) consensus motif; other site
444177011018	AMP binding site [chemical binding]; other site
444177011019	active site
444177011020	CoA binding site [chemical binding]; other site
444177011021	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
444177011022	substrate binding site [chemical binding]; other site
444177011023	multimerization interface [polypeptide binding]; other site
444177011024	ATP binding site [chemical binding]; other site
444177011025	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
444177011026	dimer interface [polypeptide binding]; other site
444177011027	substrate binding site [chemical binding]; other site
444177011028	ATP binding site [chemical binding]; other site
444177011029	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
444177011030	thiamine phosphate binding site [chemical binding]; other site
444177011031	active site
444177011032	pyrophosphate binding site [ion binding]; other site
444177011033	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
444177011034	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
444177011035	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
444177011036	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
444177011037	Ligand Binding Site [chemical binding]; other site
444177011038	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
444177011039	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
444177011040	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177011041	catalytic residue [active]
444177011042	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
444177011043	histidinol-phosphatase; Reviewed; Region: PRK08123
444177011044	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
444177011045	active site
444177011046	dimer interface [polypeptide binding]; other site
444177011047	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
444177011048	GAF domain; Region: GAF_2; pfam13185
444177011049	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177011050	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177011051	metal binding site [ion binding]; metal-binding site
444177011052	active site
444177011053	I-site; other site
444177011054	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
444177011055	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
444177011056	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
444177011057	RNA binding surface [nucleotide binding]; other site
444177011058	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
444177011059	Domain of unknown function (DUF771); Region: DUF771; cl09962
444177011060	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
444177011061	Phage capsid family; Region: Phage_capsid; pfam05065
444177011062	DNA binding residues [nucleotide binding]
444177011063	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
444177011064	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
444177011065	Uncharacterized conserved protein [Function unknown]; Region: COG4983
444177011066	Domain of unknown function (DUF927); Region: DUF927; cl12098
444177011067	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177011068	sequence-specific DNA binding site [nucleotide binding]; other site
444177011069	salt bridge; other site
444177011070	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
444177011071	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
444177011072	non-specific DNA binding site [nucleotide binding]; other site
444177011073	salt bridge; other site
444177011074	sequence-specific DNA binding site [nucleotide binding]; other site
444177011075	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
444177011076	Int/Topo IB signature motif; other site
444177011077	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
444177011078	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177011079	dimerization interface [polypeptide binding]; other site
444177011080	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177011081	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177011082	dimer interface [polypeptide binding]; other site
444177011083	putative CheW interface [polypeptide binding]; other site
444177011084	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
444177011085	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
444177011086	classical (c) SDRs; Region: SDR_c; cd05233
444177011087	NAD(P) binding site [chemical binding]; other site
444177011088	active site
444177011089	Predicted transcriptional regulators [Transcription]; Region: COG1733
444177011090	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177011091	putative DNA binding site [nucleotide binding]; other site
444177011092	putative Zn2+ binding site [ion binding]; other site
444177011093	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
444177011094	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
444177011095	dimer interface [polypeptide binding]; other site
444177011096	active site
444177011097	metal binding site [ion binding]; metal-binding site
444177011098	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
444177011099	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
444177011100	cobalamin binding residues [chemical binding]; other site
444177011101	putative BtuC binding residues; other site
444177011102	dimer interface [polypeptide binding]; other site
444177011103	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
444177011104	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
444177011105	active site
444177011106	HIGH motif; other site
444177011107	dimer interface [polypeptide binding]; other site
444177011108	KMSKS motif; other site
444177011109	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
444177011110	RNA binding surface [nucleotide binding]; other site
444177011111	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
444177011112	Transglycosylase; Region: Transgly; pfam00912
444177011113	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
444177011114	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
444177011115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177011116	NAD(P) binding site [chemical binding]; other site
444177011117	active site
444177011118	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
444177011119	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
444177011120	inhibitor-cofactor binding pocket; inhibition site
444177011121	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177011122	catalytic residue [active]
444177011123	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
444177011124	nucleotide binding site [chemical binding]; other site
444177011125	N-acetyl-L-glutamate binding site [chemical binding]; other site
444177011126	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
444177011127	heterotetramer interface [polypeptide binding]; other site
444177011128	active site pocket [active]
444177011129	cleavage site
444177011130	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
444177011131	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
444177011132	acetyl-CoA synthetase; Provisional; Region: PRK04319
444177011133	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
444177011134	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
444177011135	active site
444177011136	acyl-activating enzyme (AAE) consensus motif; other site
444177011137	putative CoA binding site [chemical binding]; other site
444177011138	AMP binding site [chemical binding]; other site
444177011139	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177011140	Coenzyme A binding pocket [chemical binding]; other site
444177011141	FOG: CBS domain [General function prediction only]; Region: COG0517
444177011142	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
444177011143	C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883
444177011144	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
444177011145	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
444177011146	active site
444177011147	Zn binding site [ion binding]; other site
444177011148	catabolite control protein A; Region: ccpA; TIGR01481
444177011149	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
444177011150	DNA binding site [nucleotide binding]
444177011151	domain linker motif; other site
444177011152	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
444177011153	dimerization interface [polypeptide binding]; other site
444177011154	effector binding site; other site
444177011155	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
444177011156	Chorismate mutase type II; Region: CM_2; cl00693
444177011157	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
444177011158	Cell division protein FtsA; Region: FtsA; smart00842
444177011159	cell division protein FtsA; Region: ftsA; TIGR01174
444177011160	Cell division protein FtsA; Region: FtsA; pfam14450
444177011161	YtxH-like protein; Region: YtxH; pfam12732
444177011162	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
444177011163	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
444177011164	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
444177011165	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
444177011166	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
444177011167	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
444177011168	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
444177011169	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
444177011170	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
444177011171	putative tRNA-binding site [nucleotide binding]; other site
444177011172	hypothetical protein; Provisional; Region: PRK13668
444177011173	NTPase; Reviewed; Region: PRK03114
444177011174	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
444177011175	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
444177011176	oligomer interface [polypeptide binding]; other site
444177011177	active site
444177011178	metal binding site [ion binding]; metal-binding site
444177011179	Predicted small secreted protein [Function unknown]; Region: COG5584
444177011180	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
444177011181	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
444177011182	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177011183	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
444177011184	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
444177011185	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
444177011186	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
444177011187	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
444177011188	homodimer interface [polypeptide binding]; other site
444177011189	substrate-cofactor binding pocket; other site
444177011190	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177011191	catalytic residue [active]
444177011192	dipeptidase PepV; Reviewed; Region: PRK07318
444177011193	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
444177011194	active site
444177011195	metal binding site [ion binding]; metal-binding site
444177011196	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177011197	putative transporter; Provisional; Region: PRK10054
444177011198	putative substrate translocation pore; other site
444177011199	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177011200	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177011201	metal binding site [ion binding]; metal-binding site
444177011202	active site
444177011203	I-site; other site
444177011204	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
444177011205	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
444177011206	RNA binding surface [nucleotide binding]; other site
444177011207	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
444177011208	active site
444177011209	uracil binding [chemical binding]; other site
444177011210	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
444177011211	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
444177011212	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
444177011213	active site
444177011214	dimer interface [polypeptide binding]; other site
444177011215	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
444177011216	Ligand Binding Site [chemical binding]; other site
444177011217	Molecular Tunnel; other site
444177011218	HI0933-like protein; Region: HI0933_like; pfam03486
444177011219	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
444177011220	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
444177011221	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
444177011222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177011223	putative substrate translocation pore; other site
444177011224	EamA-like transporter family; Region: EamA; pfam00892
444177011225	putative deaminase; Validated; Region: PRK06846
444177011226	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
444177011227	active site
444177011228	putative deaminase; Validated; Region: PRK06846
444177011229	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
444177011230	active site
444177011231	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
444177011232	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
444177011233	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
444177011234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177011235	dimer interface [polypeptide binding]; other site
444177011236	conserved gate region; other site
444177011237	putative PBP binding loops; other site
444177011238	ABC-ATPase subunit interface; other site
444177011239	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177011240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177011241	dimer interface [polypeptide binding]; other site
444177011242	conserved gate region; other site
444177011243	putative PBP binding loops; other site
444177011244	ABC-ATPase subunit interface; other site
444177011245	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
444177011246	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177011247	Walker A/P-loop; other site
444177011248	ATP binding site [chemical binding]; other site
444177011249	Q-loop/lid; other site
444177011250	ABC transporter signature motif; other site
444177011251	Walker B; other site
444177011252	D-loop; other site
444177011253	H-loop/switch region; other site
444177011254	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
444177011255	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
444177011256	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177011257	Walker A/P-loop; other site
444177011258	ATP binding site [chemical binding]; other site
444177011259	Q-loop/lid; other site
444177011260	ABC transporter signature motif; other site
444177011261	Walker B; other site
444177011262	D-loop; other site
444177011263	H-loop/switch region; other site
444177011264	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
444177011265	Histidine kinase; Region: His_kinase; pfam06580
444177011266	Response regulator receiver domain; Region: Response_reg; pfam00072
444177011267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177011268	active site
444177011269	phosphorylation site [posttranslational modification]
444177011270	intermolecular recognition site; other site
444177011271	dimerization interface [polypeptide binding]; other site
444177011272	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
444177011273	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177011274	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177011275	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
444177011276	Nucleoside recognition; Region: Gate; pfam07670
444177011277	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
444177011278	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
444177011279	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
444177011280	HIGH motif; other site
444177011281	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
444177011282	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
444177011283	active site
444177011284	KMSKS motif; other site
444177011285	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
444177011286	tRNA binding surface [nucleotide binding]; other site
444177011287	putative transporter; Provisional; Region: PRK11660
444177011288	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
444177011289	Sulfate transporter family; Region: Sulfate_transp; pfam00916
444177011290	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
444177011291	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177011292	dimerization interface [polypeptide binding]; other site
444177011293	putative DNA binding site [nucleotide binding]; other site
444177011294	putative Zn2+ binding site [ion binding]; other site
444177011295	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177011296	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177011297	putative substrate translocation pore; other site
444177011298	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
444177011299	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
444177011300	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
444177011301	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
444177011302	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
444177011303	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
444177011304	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
444177011305	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
444177011306	trimer interface [polypeptide binding]; other site
444177011307	putative metal binding site [ion binding]; other site
444177011308	S-adenosylmethionine synthetase; Validated; Region: PRK05250
444177011309	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
444177011310	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
444177011311	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
444177011312	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
444177011313	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
444177011314	active site
444177011315	substrate-binding site [chemical binding]; other site
444177011316	metal-binding site [ion binding]
444177011317	ATP binding site [chemical binding]; other site
444177011318	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
444177011319	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
444177011320	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
444177011321	Dienelactone hydrolase family; Region: DLH; pfam01738
444177011322	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
444177011323	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
444177011324	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
444177011325	nudix motif; other site
444177011326	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
444177011327	Transcriptional regulator [Transcription]; Region: IclR; COG1414
444177011328	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
444177011329	Bacterial transcriptional regulator; Region: IclR; pfam01614
444177011330	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
444177011331	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
444177011332	metal binding site [ion binding]; metal-binding site
444177011333	dimer interface [polypeptide binding]; other site
444177011334	Protein of unknown function (DUF1177); Region: DUF1177; pfam06675
444177011335	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
444177011336	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177011337	Walker A/P-loop; other site
444177011338	ATP binding site [chemical binding]; other site
444177011339	Q-loop/lid; other site
444177011340	ABC transporter signature motif; other site
444177011341	Walker B; other site
444177011342	D-loop; other site
444177011343	H-loop/switch region; other site
444177011344	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
444177011345	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
444177011346	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
444177011347	Walker A/P-loop; other site
444177011348	ATP binding site [chemical binding]; other site
444177011349	Q-loop/lid; other site
444177011350	ABC transporter signature motif; other site
444177011351	Walker B; other site
444177011352	D-loop; other site
444177011353	H-loop/switch region; other site
444177011354	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
444177011355	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
444177011356	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
444177011357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177011358	dimer interface [polypeptide binding]; other site
444177011359	conserved gate region; other site
444177011360	putative PBP binding loops; other site
444177011361	ABC-ATPase subunit interface; other site
444177011362	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
444177011363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177011364	dimer interface [polypeptide binding]; other site
444177011365	conserved gate region; other site
444177011366	putative PBP binding loops; other site
444177011367	ABC-ATPase subunit interface; other site
444177011368	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
444177011369	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
444177011370	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
444177011371	Amidohydrolase; Region: Amidohydro_4; pfam13147
444177011372	active site
444177011373	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
444177011374	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
444177011375	active site
444177011376	AroM protein; Region: AroM; pfam07302
444177011377	Haemolytic domain; Region: Haemolytic; pfam01809
444177011378	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
444177011379	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177011380	intersubunit interface [polypeptide binding]; other site
444177011381	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
444177011382	putative AMP binding site [chemical binding]; other site
444177011383	putative active site [active]
444177011384	acyl-activating enzyme (AAE) consensus motif; other site
444177011385	putative CoA binding site [chemical binding]; other site
444177011386	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
444177011387	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
444177011388	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
444177011389	substrate binding site [chemical binding]; other site
444177011390	oxyanion hole (OAH) forming residues; other site
444177011391	trimer interface [polypeptide binding]; other site
444177011392	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
444177011393	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
444177011394	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
444177011395	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
444177011396	dimer interface [polypeptide binding]; other site
444177011397	tetramer interface [polypeptide binding]; other site
444177011398	PYR/PP interface [polypeptide binding]; other site
444177011399	TPP binding site [chemical binding]; other site
444177011400	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
444177011401	TPP-binding site; other site
444177011402	chorismate binding enzyme; Region: Chorismate_bind; cl10555
444177011403	chorismate binding enzyme; Region: Chorismate_bind; cl10555
444177011404	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
444177011405	UbiA prenyltransferase family; Region: UbiA; pfam01040
444177011406	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
444177011407	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
444177011408	active site
444177011409	dimer interface [polypeptide binding]; other site
444177011410	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
444177011411	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
444177011412	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
444177011413	DNA binding residues [nucleotide binding]
444177011414	dimer interface [polypeptide binding]; other site
444177011415	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
444177011416	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
444177011417	Double zinc ribbon; Region: DZR; pfam12773
444177011418	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
444177011419	Peptidase family C4; Region: Peptidase_C4; pfam00863
444177011420	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
444177011421	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
444177011422	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177011423	catalytic residue [active]
444177011424	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177011425	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
444177011426	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
444177011427	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
444177011428	catalytic residue [active]
444177011429	L-aspartate oxidase; Provisional; Region: PRK06175
444177011430	L-aspartate oxidase; Provisional; Region: PRK08071
444177011431	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
444177011432	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
444177011433	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
444177011434	dimerization interface [polypeptide binding]; other site
444177011435	active site
444177011436	quinolinate synthetase; Provisional; Region: PRK09375
444177011437	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
444177011438	hypothetical protein; Provisional; Region: PRK04351
444177011439	SprT homologues; Region: SprT; cl01182
444177011440	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
444177011441	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
444177011442	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
444177011443	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
444177011444	RNA binding site [nucleotide binding]; other site
444177011445	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
444177011446	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177011447	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
444177011448	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177011449	DNA binding residues [nucleotide binding]
444177011450	serine-protein kinase RsbW; Provisional; Region: PRK04069
444177011451	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
444177011452	ATP binding site [chemical binding]; other site
444177011453	Mg2+ binding site [ion binding]; other site
444177011454	G-X-G motif; other site
444177011455	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
444177011456	anti sigma factor interaction site; other site
444177011457	regulatory phosphorylation site [posttranslational modification]; other site
444177011458	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
444177011459	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
444177011460	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
444177011461	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
444177011462	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
444177011463	ATP binding site [chemical binding]; other site
444177011464	G-X-G motif; other site
444177011465	PemK-like protein; Region: PemK; pfam02452
444177011466	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
444177011467	alanine racemase; Reviewed; Region: alr; PRK00053
444177011468	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
444177011469	active site
444177011470	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
444177011471	dimer interface [polypeptide binding]; other site
444177011472	substrate binding site [chemical binding]; other site
444177011473	catalytic residues [active]
444177011474	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
444177011475	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
444177011476	Rhomboid family; Region: Rhomboid; pfam01694
444177011477	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177011478	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
444177011479	Predicted membrane protein [Function unknown]; Region: COG3428
444177011480	Bacterial PH domain; Region: DUF304; pfam03703
444177011481	Bacterial PH domain; Region: DUF304; pfam03703
444177011482	Bacterial PH domain; Region: DUF304; pfam03703
444177011483	Uncharacterized conserved protein [Function unknown]; Region: COG3402
444177011484	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
444177011485	DEAD-like helicases superfamily; Region: DEXDc; smart00487
444177011486	ATP binding site [chemical binding]; other site
444177011487	Mg++ binding site [ion binding]; other site
444177011488	motif III; other site
444177011489	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
444177011490	nucleotide binding region [chemical binding]; other site
444177011491	ATP-binding site [chemical binding]; other site
444177011492	Esterase/lipase [General function prediction only]; Region: COG1647
444177011493	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
444177011494	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
444177011495	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
444177011496	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
444177011497	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
444177011498	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
444177011499	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
444177011500	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
444177011501	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
444177011502	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
444177011503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177011504	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177011505	putative substrate translocation pore; other site
444177011506	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
444177011507	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
444177011508	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
444177011509	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177011510	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177011511	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177011512	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
444177011513	LytTr DNA-binding domain; Region: LytTR; smart00850
444177011514	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
444177011515	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
444177011516	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
444177011517	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177011518	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177011519	putative substrate translocation pore; other site
444177011520	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177011521	Coenzyme A binding pocket [chemical binding]; other site
444177011522	Predicted secreted protein [Function unknown]; Region: COG4086
444177011523	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
444177011524	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
444177011525	S1 domain; Region: S1_2; pfam13509
444177011526	manganese transport transcriptional regulator; Provisional; Region: PRK03902
444177011527	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
444177011528	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
444177011529	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
444177011530	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
444177011531	metal-binding site [ion binding]
444177011532	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
444177011533	Soluble P-type ATPase [General function prediction only]; Region: COG4087
444177011534	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177011535	dimerization interface [polypeptide binding]; other site
444177011536	putative DNA binding site [nucleotide binding]; other site
444177011537	putative Zn2+ binding site [ion binding]; other site
444177011538	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
444177011539	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
444177011540	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
444177011541	active site
444177011542	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
444177011543	active site
444177011544	putative catalytic site [active]
444177011545	DNA binding site [nucleotide binding]
444177011546	putative phosphate binding site [ion binding]; other site
444177011547	metal binding site A [ion binding]; metal-binding site
444177011548	AP binding site [nucleotide binding]; other site
444177011549	metal binding site B [ion binding]; metal-binding site
444177011550	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
444177011551	FAD binding domain; Region: FAD_binding_4; pfam01565
444177011552	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
444177011553	Predicted transcriptional regulators [Transcription]; Region: COG1733
444177011554	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
444177011555	Uncharacterized conserved protein [Function unknown]; Region: COG2353
444177011556	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
444177011557	S-layer homology domain; Region: SLH; pfam00395
444177011558	S-layer homology domain; Region: SLH; pfam00395
444177011559	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
444177011560	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
444177011561	active site
444177011562	metal binding site [ion binding]; metal-binding site
444177011563	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
444177011564	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
444177011565	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
444177011566	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
444177011567	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
444177011568	catalytic residues [active]
444177011569	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
444177011570	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
444177011571	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
444177011572	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
444177011573	iron-sulfur cluster [ion binding]; other site
444177011574	[2Fe-2S] cluster binding site [ion binding]; other site
444177011575	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
444177011576	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
444177011577	DHHA2 domain; Region: DHHA2; pfam02833
444177011578	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177011579	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177011580	Coenzyme A binding pocket [chemical binding]; other site
444177011581	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
444177011582	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
444177011583	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
444177011584	putative active site [active]
444177011585	benzoate transport; Region: 2A0115; TIGR00895
444177011586	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177011587	putative substrate translocation pore; other site
444177011588	threonine synthase; Reviewed; Region: PRK06721
444177011589	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
444177011590	homodimer interface [polypeptide binding]; other site
444177011591	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177011592	catalytic residue [active]
444177011593	homoserine kinase; Provisional; Region: PRK01212
444177011594	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
444177011595	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
444177011596	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
444177011597	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177011598	motif II; other site
444177011599	zinc transporter ZupT; Provisional; Region: PRK04201
444177011600	ZIP Zinc transporter; Region: Zip; pfam02535
444177011601	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
444177011602	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
444177011603	active site
444177011604	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177011605	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177011606	active site
444177011607	phosphorylation site [posttranslational modification]
444177011608	intermolecular recognition site; other site
444177011609	dimerization interface [polypeptide binding]; other site
444177011610	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
444177011611	DNA binding residues [nucleotide binding]
444177011612	dimerization interface [polypeptide binding]; other site
444177011613	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
444177011614	Histidine kinase; Region: HisKA_3; pfam07730
444177011615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177011616	ATP binding site [chemical binding]; other site
444177011617	Mg2+ binding site [ion binding]; other site
444177011618	G-X-G motif; other site
444177011619	Bacillus competence pheromone ComX; Region: ComX; pfam05952
444177011620	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
444177011621	substrate binding pocket [chemical binding]; other site
444177011622	substrate-Mg2+ binding site; other site
444177011623	aspartate-rich region 1; other site
444177011624	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
444177011625	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
444177011626	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
444177011627	putative ligand binding residues [chemical binding]; other site
444177011628	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
444177011629	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
444177011630	Walker A/P-loop; other site
444177011631	ATP binding site [chemical binding]; other site
444177011632	Q-loop/lid; other site
444177011633	ABC transporter signature motif; other site
444177011634	Walker B; other site
444177011635	D-loop; other site
444177011636	H-loop/switch region; other site
444177011637	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177011638	ABC-ATPase subunit  interface; other site
444177011639	dimer interface [polypeptide binding]; other site
444177011640	putative PBP binding regions; other site
444177011641	Uncharacterized membrane protein [Function unknown]; Region: COG3949
444177011642	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
444177011643	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
444177011644	active site
444177011645	octamer interface [polypeptide binding]; other site
444177011646	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177011647	Coenzyme A binding pocket [chemical binding]; other site
444177011648	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
444177011649	M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018
444177011650	metal binding site [ion binding]; metal-binding site
444177011651	putative dimer interface [polypeptide binding]; other site
444177011652	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
444177011653	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177011654	putative substrate translocation pore; other site
444177011655	POT family; Region: PTR2; cl17359
444177011656	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
444177011657	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
444177011658	HflX GTPase family; Region: HflX; cd01878
444177011659	G1 box; other site
444177011660	GTP/Mg2+ binding site [chemical binding]; other site
444177011661	Switch I region; other site
444177011662	G2 box; other site
444177011663	G3 box; other site
444177011664	Switch II region; other site
444177011665	G4 box; other site
444177011666	G5 box; other site
444177011667	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
444177011668	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
444177011669	Na binding site [ion binding]; other site
444177011670	Methyltransferase domain; Region: Methyltransf_31; pfam13847
444177011671	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177011672	S-adenosylmethionine binding site [chemical binding]; other site
444177011673	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
444177011674	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
444177011675	FtsX-like permease family; Region: FtsX; pfam02687
444177011676	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
444177011677	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
444177011678	Walker A/P-loop; other site
444177011679	ATP binding site [chemical binding]; other site
444177011680	Q-loop/lid; other site
444177011681	ABC transporter signature motif; other site
444177011682	Walker B; other site
444177011683	D-loop; other site
444177011684	H-loop/switch region; other site
444177011685	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
444177011686	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
444177011687	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
444177011688	Predicted esterase [General function prediction only]; Region: COG0400
444177011689	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
444177011690	nudix motif; other site
444177011691	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
444177011692	Domain of unknown function DUF20; Region: UPF0118; pfam01594
444177011693	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
444177011694	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
444177011695	active site
444177011696	Zn binding site [ion binding]; other site
444177011697	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
444177011698	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177011699	dimerization interface [polypeptide binding]; other site
444177011700	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177011701	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177011702	dimer interface [polypeptide binding]; other site
444177011703	putative CheW interface [polypeptide binding]; other site
444177011704	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177011705	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177011706	dimer interface [polypeptide binding]; other site
444177011707	putative CheW interface [polypeptide binding]; other site
444177011708	hypothetical protein; Provisional; Region: PRK12378
444177011709	Transcriptional regulator; Region: Transcrip_reg; cl00361
444177011710	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
444177011711	Low molecular weight phosphatase family; Region: LMWPc; cd00115
444177011712	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
444177011713	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
444177011714	putative acyl-acceptor binding pocket; other site
444177011715	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
444177011716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177011717	S-adenosylmethionine binding site [chemical binding]; other site
444177011718	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
444177011719	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
444177011720	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
444177011721	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
444177011722	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177011723	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
444177011724	putative binding site residues; other site
444177011725	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
444177011726	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
444177011727	catalytic residues [active]
444177011728	dimer interface [polypeptide binding]; other site
444177011729	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
444177011730	Domain of unknown function DUF20; Region: UPF0118; pfam01594
444177011731	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
444177011732	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
444177011733	NlpC/P60 family; Region: NLPC_P60; pfam00877
444177011734	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
444177011735	ABC1 family; Region: ABC1; cl17513
444177011736	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
444177011737	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
444177011738	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
444177011739	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
444177011740	active site residue [active]
444177011741	Cytochrome c [Energy production and conversion]; Region: COG3258
444177011742	Cytochrome c; Region: Cytochrom_C; pfam00034
444177011743	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
444177011744	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
444177011745	catalytic residues [active]
444177011746	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
444177011747	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
444177011748	CPxP  motif; other site
444177011749	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
444177011750	active site residue [active]
444177011751	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177011752	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
444177011753	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
444177011754	CPxP  motif; other site
444177011755	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
444177011756	active site residue [active]
444177011757	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
444177011758	active site residue [active]
444177011759	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
444177011760	active site residue [active]
444177011761	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
444177011762	putative homodimer interface [polypeptide binding]; other site
444177011763	putative homotetramer interface [polypeptide binding]; other site
444177011764	putative metal binding site [ion binding]; other site
444177011765	putative homodimer-homodimer interface [polypeptide binding]; other site
444177011766	putative allosteric switch controlling residues; other site
444177011767	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
444177011768	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
444177011769	heme-binding site [chemical binding]; other site
444177011770	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
444177011771	FAD binding pocket [chemical binding]; other site
444177011772	FAD binding motif [chemical binding]; other site
444177011773	phosphate binding motif [ion binding]; other site
444177011774	beta-alpha-beta structure motif; other site
444177011775	NAD binding pocket [chemical binding]; other site
444177011776	Heme binding  pocket [chemical binding]; other site
444177011777	Transcriptional regulator; Region: Rrf2; cl17282
444177011778	Rrf2 family protein; Region: rrf2_super; TIGR00738
444177011779	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177011780	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177011781	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
444177011782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177011783	Coenzyme A binding pocket [chemical binding]; other site
444177011784	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
444177011785	dimer interface [polypeptide binding]; other site
444177011786	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177011787	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
444177011788	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
444177011789	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177011790	dimerization interface [polypeptide binding]; other site
444177011791	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177011792	dimer interface [polypeptide binding]; other site
444177011793	putative CheW interface [polypeptide binding]; other site
444177011794	2-isopropylmalate synthase; Validated; Region: PRK00915
444177011795	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
444177011796	active site
444177011797	catalytic residues [active]
444177011798	metal binding site [ion binding]; metal-binding site
444177011799	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
444177011800	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
444177011801	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
444177011802	active site
444177011803	HIGH motif; other site
444177011804	KMSKS motif; other site
444177011805	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
444177011806	tRNA binding surface [nucleotide binding]; other site
444177011807	anticodon binding site; other site
444177011808	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
444177011809	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
444177011810	motif II; other site
444177011811	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
444177011812	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
444177011813	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
444177011814	active site
444177011815	ribosome small subunit-dependent GTPase A; Region: TIGR00157
444177011816	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
444177011817	GTPase/Zn-binding domain interface [polypeptide binding]; other site
444177011818	GTP/Mg2+ binding site [chemical binding]; other site
444177011819	G4 box; other site
444177011820	G5 box; other site
444177011821	G1 box; other site
444177011822	Switch I region; other site
444177011823	G2 box; other site
444177011824	G3 box; other site
444177011825	Switch II region; other site
444177011826	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
444177011827	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
444177011828	malonyl-CoA binding site [chemical binding]; other site
444177011829	dimer interface [polypeptide binding]; other site
444177011830	active site
444177011831	product binding site; other site
444177011832	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
444177011833	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
444177011834	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
444177011835	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
444177011836	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
444177011837	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
444177011838	BclB C-terminal domain; Region: exospore_TM; TIGR03721
444177011839	metal-dependent hydrolase; Provisional; Region: PRK13291
444177011840	DinB superfamily; Region: DinB_2; pfam12867
444177011841	BCCT family transporter; Region: BCCT; pfam02028
444177011842	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
444177011843	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
444177011844	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
444177011845	Walker A/P-loop; other site
444177011846	ATP binding site [chemical binding]; other site
444177011847	Q-loop/lid; other site
444177011848	ABC transporter signature motif; other site
444177011849	Walker B; other site
444177011850	D-loop; other site
444177011851	H-loop/switch region; other site
444177011852	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
444177011853	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177011854	ABC-ATPase subunit  interface; other site
444177011855	dimer interface [polypeptide binding]; other site
444177011856	putative PBP binding regions; other site
444177011857	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
444177011858	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
444177011859	ABC-ATPase subunit  interface; other site
444177011860	dimer interface [polypeptide binding]; other site
444177011861	putative PBP binding regions; other site
444177011862	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177011863	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
444177011864	intersubunit interface [polypeptide binding]; other site
444177011865	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
444177011866	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177011867	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177011868	DinB superfamily; Region: DinB_2; pfam12867
444177011869	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
444177011870	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
444177011871	SnoaL-like domain; Region: SnoaL_3; pfam13474
444177011872	SnoaL-like domain; Region: SnoaL_2; pfam12680
444177011873	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
444177011874	putative hydrophobic ligand binding site [chemical binding]; other site
444177011875	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
444177011876	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177011877	ABC transporter; Region: ABC_tran_2; pfam12848
444177011878	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177011879	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
444177011880	putative active site [active]
444177011881	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
444177011882	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
444177011883	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
444177011884	NodB motif; other site
444177011885	active site
444177011886	catalytic site [active]
444177011887	metal binding site [ion binding]; metal-binding site
444177011888	Domain of unknown function (DUF1805); Region: DUF1805; cl01339
444177011889	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
444177011890	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
444177011891	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
444177011892	catalytic core [active]
444177011893	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
444177011894	EamA-like transporter family; Region: EamA; pfam00892
444177011895	EamA-like transporter family; Region: EamA; pfam00892
444177011896	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
444177011897	EamA-like transporter family; Region: EamA; pfam00892
444177011898	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
444177011899	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177011900	DNA-binding site [nucleotide binding]; DNA binding site
444177011901	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177011902	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177011903	homodimer interface [polypeptide binding]; other site
444177011904	catalytic residue [active]
444177011905	Helix-turn-helix domain; Region: HTH_18; pfam12833
444177011906	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177011907	Erythromycin esterase; Region: Erythro_esteras; pfam05139
444177011908	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
444177011909	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
444177011910	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
444177011911	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
444177011912	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
444177011913	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
444177011914	Walker A/P-loop; other site
444177011915	ATP binding site [chemical binding]; other site
444177011916	Q-loop/lid; other site
444177011917	ABC transporter signature motif; other site
444177011918	Walker B; other site
444177011919	D-loop; other site
444177011920	H-loop/switch region; other site
444177011921	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177011922	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177011923	dimerization interface [polypeptide binding]; other site
444177011924	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177011925	dimer interface [polypeptide binding]; other site
444177011926	phosphorylation site [posttranslational modification]
444177011927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177011928	ATP binding site [chemical binding]; other site
444177011929	Mg2+ binding site [ion binding]; other site
444177011930	G-X-G motif; other site
444177011931	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177011932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177011933	active site
444177011934	phosphorylation site [posttranslational modification]
444177011935	intermolecular recognition site; other site
444177011936	dimerization interface [polypeptide binding]; other site
444177011937	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177011938	DNA binding site [nucleotide binding]
444177011939	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177011940	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
444177011941	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
444177011942	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
444177011943	active site
444177011944	catalytic tetrad [active]
444177011945	Predicted transcriptional regulators [Transcription]; Region: COG1733
444177011946	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
444177011947	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177011948	Major Facilitator Superfamily; Region: MFS_1; pfam07690
444177011949	putative substrate translocation pore; other site
444177011950	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
444177011951	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177011952	intersubunit interface [polypeptide binding]; other site
444177011953	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
444177011954	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
444177011955	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
444177011956	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
444177011957	intersubunit interface [polypeptide binding]; other site
444177011958	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
444177011959	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
444177011960	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
444177011961	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177011962	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
444177011963	active site
444177011964	motif I; other site
444177011965	motif II; other site
444177011966	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
444177011967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
444177011968	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
444177011969	flagellar operon protein TIGR03826; Region: YvyF
444177011970	Helix-turn-helix domain; Region: HTH_17; cl17695
444177011971	Erythromycin esterase; Region: Erythro_esteras; pfam05139
444177011972	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
444177011973	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
444177011974	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
444177011975	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177011976	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
444177011977	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
444177011978	Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782
444177011979	DNA binding residues [nucleotide binding]
444177011980	dimer interface [polypeptide binding]; other site
444177011981	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
444177011982	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177011983	Coenzyme A binding pocket [chemical binding]; other site
444177011984	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
444177011985	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
444177011986	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
444177011987	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
444177011988	Coenzyme A binding pocket [chemical binding]; other site
444177011989	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177011990	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177011991	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
444177011992	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
444177011993	homotrimer interaction site [polypeptide binding]; other site
444177011994	putative active site [active]
444177011995	Predicted flavoprotein [General function prediction only]; Region: COG0431
444177011996	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
444177011997	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
444177011998	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
444177011999	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
444177012000	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
444177012001	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
444177012002	putative DNA binding site [nucleotide binding]; other site
444177012003	putative Zn2+ binding site [ion binding]; other site
444177012004	AsnC family; Region: AsnC_trans_reg; pfam01037
444177012005	Uncharacterized conserved protein [Function unknown]; Region: COG2128
444177012006	Rrf2 family protein; Region: rrf2_super; TIGR00738
444177012007	Transcriptional regulator; Region: Rrf2; pfam02082
444177012008	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
444177012009	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
444177012010	putative hydrophobic ligand binding site [chemical binding]; other site
444177012011	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177012012	dimerization interface [polypeptide binding]; other site
444177012013	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177012014	dimer interface [polypeptide binding]; other site
444177012015	phosphorylation site [posttranslational modification]
444177012016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177012017	ATP binding site [chemical binding]; other site
444177012018	Mg2+ binding site [ion binding]; other site
444177012019	G-X-G motif; other site
444177012020	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177012021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177012022	active site
444177012023	phosphorylation site [posttranslational modification]
444177012024	intermolecular recognition site; other site
444177012025	dimerization interface [polypeptide binding]; other site
444177012026	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177012027	DNA binding site [nucleotide binding]
444177012028	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
444177012029	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177012030	ABC transporter; Region: ABC_tran_2; pfam12848
444177012031	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
444177012032	Uncharacterized conserved protein [Function unknown]; Region: COG1284
444177012033	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
444177012034	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
444177012035	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
444177012036	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
444177012037	ATP-grasp domain; Region: ATP-grasp_4; cl17255
444177012038	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
444177012039	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177012040	DNA-binding site [nucleotide binding]; DNA binding site
444177012041	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177012042	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177012043	homodimer interface [polypeptide binding]; other site
444177012044	catalytic residue [active]
444177012045	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
444177012046	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
444177012047	Walker A/P-loop; other site
444177012048	ATP binding site [chemical binding]; other site
444177012049	Q-loop/lid; other site
444177012050	ABC transporter signature motif; other site
444177012051	Walker B; other site
444177012052	D-loop; other site
444177012053	H-loop/switch region; other site
444177012054	Predicted membrane protein [Function unknown]; Region: COG1511
444177012055	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
444177012056	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
444177012057	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
444177012058	Walker A/P-loop; other site
444177012059	ATP binding site [chemical binding]; other site
444177012060	Q-loop/lid; other site
444177012061	ABC transporter signature motif; other site
444177012062	Walker B; other site
444177012063	D-loop; other site
444177012064	H-loop/switch region; other site
444177012065	Predicted transcriptional regulators [Transcription]; Region: COG1725
444177012066	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177012067	DNA-binding site [nucleotide binding]; DNA binding site
444177012068	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
444177012069	putative DNA binding site [nucleotide binding]; other site
444177012070	putative Zn2+ binding site [ion binding]; other site
444177012071	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
444177012072	RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642
444177012073	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177012074	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177012075	DNA binding residues [nucleotide binding]
444177012076	TraB family; Region: TraB; pfam01963
444177012077	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177012078	NPCBM/NEW2 domain; Region: NPCBM; cl07060
444177012079	short chain dehydrogenase; Provisional; Region: PRK07041
444177012080	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
444177012081	NAD(P) binding site [chemical binding]; other site
444177012082	active site
444177012083	Predicted transcriptional regulators [Transcription]; Region: COG1733
444177012084	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
444177012085	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
444177012086	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
444177012087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177012088	active site
444177012089	phosphorylation site [posttranslational modification]
444177012090	intermolecular recognition site; other site
444177012091	dimerization interface [polypeptide binding]; other site
444177012092	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
444177012093	DNA binding residues [nucleotide binding]
444177012094	dimerization interface [polypeptide binding]; other site
444177012095	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
444177012096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177012097	ATP binding site [chemical binding]; other site
444177012098	Mg2+ binding site [ion binding]; other site
444177012099	G-X-G motif; other site
444177012100	Bacillus competence pheromone ComX; Region: ComX; pfam05952
444177012101	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
444177012102	substrate binding pocket [chemical binding]; other site
444177012103	aspartate-rich region 2; other site
444177012104	substrate-Mg2+ binding site; other site
444177012105	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177012106	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177012107	active site
444177012108	phosphorylation site [posttranslational modification]
444177012109	intermolecular recognition site; other site
444177012110	dimerization interface [polypeptide binding]; other site
444177012111	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177012112	DNA binding site [nucleotide binding]
444177012113	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177012114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
444177012115	dimer interface [polypeptide binding]; other site
444177012116	phosphorylation site [posttranslational modification]
444177012117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177012118	ATP binding site [chemical binding]; other site
444177012119	Mg2+ binding site [ion binding]; other site
444177012120	G-X-G motif; other site
444177012121	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
444177012122	ApbE family; Region: ApbE; pfam02424
444177012123	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
444177012124	Integrase core domain; Region: rve_3; cl15866
444177012125	short chain dehydrogenase; Provisional; Region: PRK12747
444177012126	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
444177012127	NADP binding site [chemical binding]; other site
444177012128	homodimer interface [polypeptide binding]; other site
444177012129	active site
444177012130	substrate binding site [chemical binding]; other site
444177012131	AAA domain; Region: AAA_18; pfam13238
444177012132	AAA domain; Region: AAA_17; pfam13207
444177012133	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
444177012134	RNA polymerase factor sigma-70; Validated; Region: PRK06811
444177012135	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177012136	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177012137	DNA binding residues [nucleotide binding]
444177012138	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
444177012139	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
444177012140	glutaminase active site [active]
444177012141	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
444177012142	dimer interface [polypeptide binding]; other site
444177012143	active site
444177012144	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
444177012145	dimer interface [polypeptide binding]; other site
444177012146	active site
444177012147	intracellular protease, PfpI family; Region: PfpI; TIGR01382
444177012148	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
444177012149	proposed catalytic triad [active]
444177012150	conserved cys residue [active]
444177012151	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
444177012152	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
444177012153	active site
444177012154	substrate binding site [chemical binding]; other site
444177012155	metal binding site [ion binding]; metal-binding site
444177012156	YbbR-like protein; Region: YbbR; pfam07949
444177012157	YbbR-like protein; Region: YbbR; pfam07949
444177012158	YbbR-like protein; Region: YbbR; pfam07949
444177012159	TIGR00159 family protein; Region: TIGR00159
444177012160	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
444177012161	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
444177012162	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
444177012163	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
444177012164	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
444177012165	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177012166	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
444177012167	DNA binding residues [nucleotide binding]
444177012168	Arginase family; Region: Arginase; cd09989
444177012169	agmatinase; Region: agmatinase; TIGR01230
444177012170	active site
444177012171	Mn binding site [ion binding]; other site
444177012172	oligomer interface [polypeptide binding]; other site
444177012173	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
444177012174	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
444177012175	active site
444177012176	acyl-activating enzyme (AAE) consensus motif; other site
444177012177	putative CoA binding site [chemical binding]; other site
444177012178	AMP binding site [chemical binding]; other site
444177012179	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
444177012180	Domain of unknown function DUF59; Region: DUF59; pfam01883
444177012181	antiporter inner membrane protein; Provisional; Region: PRK11670
444177012182	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
444177012183	Walker A motif; other site
444177012184	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
444177012185	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
444177012186	active site
444177012187	metal binding site [ion binding]; metal-binding site
444177012188	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
444177012189	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333
444177012190	23S rRNA interface [nucleotide binding]; other site
444177012191	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
444177012192	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
444177012193	dimerization interface 3.5A [polypeptide binding]; other site
444177012194	active site
444177012195	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
444177012196	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
444177012197	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
444177012198	Walker A/P-loop; other site
444177012199	ATP binding site [chemical binding]; other site
444177012200	Q-loop/lid; other site
444177012201	ABC transporter signature motif; other site
444177012202	Walker B; other site
444177012203	D-loop; other site
444177012204	H-loop/switch region; other site
444177012205	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
444177012206	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
444177012207	Walker A/P-loop; other site
444177012208	ATP binding site [chemical binding]; other site
444177012209	Q-loop/lid; other site
444177012210	ABC transporter signature motif; other site
444177012211	Walker B; other site
444177012212	D-loop; other site
444177012213	H-loop/switch region; other site
444177012214	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
444177012215	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
444177012216	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
444177012217	alphaNTD homodimer interface [polypeptide binding]; other site
444177012218	alphaNTD - beta interaction site [polypeptide binding]; other site
444177012219	alphaNTD - beta' interaction site [polypeptide binding]; other site
444177012220	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
444177012221	30S ribosomal protein S11; Validated; Region: PRK05309
444177012222	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
444177012223	30S ribosomal protein S13; Region: bact_S13; TIGR03631
444177012224	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
444177012225	rRNA binding site [nucleotide binding]; other site
444177012226	predicted 30S ribosome binding site; other site
444177012227	adenylate kinase; Reviewed; Region: adk; PRK00279
444177012228	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
444177012229	AMP-binding site [chemical binding]; other site
444177012230	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
444177012231	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
444177012232	SecY translocase; Region: SecY; pfam00344
444177012233	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
444177012234	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
444177012235	23S rRNA binding site [nucleotide binding]; other site
444177012236	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
444177012237	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
444177012238	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
444177012239	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
444177012240	5S rRNA interface [nucleotide binding]; other site
444177012241	L27 interface [polypeptide binding]; other site
444177012242	23S rRNA interface [nucleotide binding]; other site
444177012243	L5 interface [polypeptide binding]; other site
444177012244	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
444177012245	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
444177012246	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
444177012247	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
444177012248	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
444177012249	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
444177012250	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
444177012251	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
444177012252	RNA binding site [nucleotide binding]; other site
444177012253	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
444177012254	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
444177012255	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
444177012256	23S rRNA interface [nucleotide binding]; other site
444177012257	putative translocon interaction site; other site
444177012258	signal recognition particle (SRP54) interaction site; other site
444177012259	L23 interface [polypeptide binding]; other site
444177012260	trigger factor interaction site; other site
444177012261	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
444177012262	23S rRNA interface [nucleotide binding]; other site
444177012263	5S rRNA interface [nucleotide binding]; other site
444177012264	putative antibiotic binding site [chemical binding]; other site
444177012265	L25 interface [polypeptide binding]; other site
444177012266	L27 interface [polypeptide binding]; other site
444177012267	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
444177012268	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
444177012269	G-X-X-G motif; other site
444177012270	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
444177012271	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
444177012272	putative translocon binding site; other site
444177012273	protein-rRNA interface [nucleotide binding]; other site
444177012274	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
444177012275	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
444177012276	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
444177012277	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
444177012278	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
444177012279	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
444177012280	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
444177012281	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
444177012282	Predicted permease [General function prediction only]; Region: COG2056
444177012283	Predicted permease [General function prediction only]; Region: COG2056
444177012284	Predicted permease [General function prediction only]; Region: COG2056
444177012285	Predicted permease [General function prediction only]; Region: COG2056
444177012286	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
444177012287	FtsX-like permease family; Region: FtsX; pfam02687
444177012288	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
444177012289	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
444177012290	Walker A/P-loop; other site
444177012291	ATP binding site [chemical binding]; other site
444177012292	Q-loop/lid; other site
444177012293	ABC transporter signature motif; other site
444177012294	Walker B; other site
444177012295	D-loop; other site
444177012296	H-loop/switch region; other site
444177012297	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177012298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177012299	ATP binding site [chemical binding]; other site
444177012300	Mg2+ binding site [ion binding]; other site
444177012301	G-X-G motif; other site
444177012302	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177012303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177012304	active site
444177012305	phosphorylation site [posttranslational modification]
444177012306	intermolecular recognition site; other site
444177012307	dimerization interface [polypeptide binding]; other site
444177012308	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177012309	DNA binding site [nucleotide binding]
444177012310	elongation factor Tu; Reviewed; Region: PRK00049
444177012311	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
444177012312	G1 box; other site
444177012313	GEF interaction site [polypeptide binding]; other site
444177012314	GTP/Mg2+ binding site [chemical binding]; other site
444177012315	Switch I region; other site
444177012316	G2 box; other site
444177012317	G3 box; other site
444177012318	Switch II region; other site
444177012319	G4 box; other site
444177012320	G5 box; other site
444177012321	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
444177012322	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
444177012323	Antibiotic Binding Site [chemical binding]; other site
444177012324	elongation factor G; Reviewed; Region: PRK00007
444177012325	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
444177012326	G1 box; other site
444177012327	putative GEF interaction site [polypeptide binding]; other site
444177012328	GTP/Mg2+ binding site [chemical binding]; other site
444177012329	Switch I region; other site
444177012330	G2 box; other site
444177012331	G3 box; other site
444177012332	Switch II region; other site
444177012333	G4 box; other site
444177012334	G5 box; other site
444177012335	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
444177012336	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
444177012337	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
444177012338	30S ribosomal protein S7; Validated; Region: PRK05302
444177012339	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
444177012340	S17 interaction site [polypeptide binding]; other site
444177012341	S8 interaction site; other site
444177012342	16S rRNA interaction site [nucleotide binding]; other site
444177012343	streptomycin interaction site [chemical binding]; other site
444177012344	23S rRNA interaction site [nucleotide binding]; other site
444177012345	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
444177012346	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
444177012347	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
444177012348	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
444177012349	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
444177012350	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
444177012351	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
444177012352	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
444177012353	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
444177012354	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
444177012355	G-loop; other site
444177012356	DNA binding site [nucleotide binding]
444177012357	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
444177012358	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
444177012359	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
444177012360	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
444177012361	RPB1 interaction site [polypeptide binding]; other site
444177012362	RPB10 interaction site [polypeptide binding]; other site
444177012363	RPB11 interaction site [polypeptide binding]; other site
444177012364	RPB3 interaction site [polypeptide binding]; other site
444177012365	RPB12 interaction site [polypeptide binding]; other site
444177012366	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
444177012367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177012368	S-adenosylmethionine binding site [chemical binding]; other site
444177012369	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
444177012370	core dimer interface [polypeptide binding]; other site
444177012371	peripheral dimer interface [polypeptide binding]; other site
444177012372	L10 interface [polypeptide binding]; other site
444177012373	L11 interface [polypeptide binding]; other site
444177012374	putative EF-Tu interaction site [polypeptide binding]; other site
444177012375	putative EF-G interaction site [polypeptide binding]; other site
444177012376	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
444177012377	23S rRNA interface [nucleotide binding]; other site
444177012378	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
444177012379	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
444177012380	mRNA/rRNA interface [nucleotide binding]; other site
444177012381	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
444177012382	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
444177012383	23S rRNA interface [nucleotide binding]; other site
444177012384	L7/L12 interface [polypeptide binding]; other site
444177012385	putative thiostrepton binding site; other site
444177012386	L25 interface [polypeptide binding]; other site
444177012387	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
444177012388	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
444177012389	putative homodimer interface [polypeptide binding]; other site
444177012390	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
444177012391	heterodimer interface [polypeptide binding]; other site
444177012392	homodimer interface [polypeptide binding]; other site
444177012393	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
444177012394	RNA polymerase factor sigma-70; Validated; Region: PRK08295
444177012395	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
444177012396	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
444177012397	DNA binding residues [nucleotide binding]
444177012398	YacP-like NYN domain; Region: NYN_YacP; pfam05991
444177012399	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
444177012400	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
444177012401	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
444177012402	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
444177012403	active site
444177012404	metal binding site [ion binding]; metal-binding site
444177012405	dimerization interface [polypeptide binding]; other site
444177012406	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
444177012407	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
444177012408	active site
444177012409	HIGH motif; other site
444177012410	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
444177012411	KMSKS motif; other site
444177012412	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
444177012413	tRNA binding surface [nucleotide binding]; other site
444177012414	anticodon binding site; other site
444177012415	serine O-acetyltransferase; Region: cysE; TIGR01172
444177012416	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
444177012417	trimer interface [polypeptide binding]; other site
444177012418	active site
444177012419	substrate binding site [chemical binding]; other site
444177012420	CoA binding site [chemical binding]; other site
444177012421	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
444177012422	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
444177012423	HIGH motif; other site
444177012424	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
444177012425	active site
444177012426	KMSKS motif; other site
444177012427	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
444177012428	homotrimer interaction site [polypeptide binding]; other site
444177012429	zinc binding site [ion binding]; other site
444177012430	CDP-binding sites; other site
444177012431	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
444177012432	substrate binding site; other site
444177012433	dimer interface; other site
444177012434	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
444177012435	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
444177012436	putative active site [active]
444177012437	DNA repair protein RadA; Provisional; Region: PRK11823
444177012438	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
444177012439	Walker A motif/ATP binding site; other site
444177012440	ATP binding site [chemical binding]; other site
444177012441	Walker B motif; other site
444177012442	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
444177012443	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
444177012444	Clp amino terminal domain; Region: Clp_N; pfam02861
444177012445	Clp amino terminal domain; Region: Clp_N; pfam02861
444177012446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177012447	Walker A motif; other site
444177012448	ATP binding site [chemical binding]; other site
444177012449	Walker B motif; other site
444177012450	arginine finger; other site
444177012451	UvrB/uvrC motif; Region: UVR; pfam02151
444177012452	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
444177012453	Walker A motif; other site
444177012454	ATP binding site [chemical binding]; other site
444177012455	Walker B motif; other site
444177012456	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
444177012457	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
444177012458	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
444177012459	ADP binding site [chemical binding]; other site
444177012460	phosphagen binding site; other site
444177012461	substrate specificity loop; other site
444177012462	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
444177012463	UvrB/uvrC motif; Region: UVR; pfam02151
444177012464	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
444177012465	Tic20-like protein; Region: Tic20; pfam09685
444177012466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177012467	S-adenosylmethionine binding site [chemical binding]; other site
444177012468	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
444177012469	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
444177012470	oligomer interface [polypeptide binding]; other site
444177012471	metal binding site [ion binding]; metal-binding site
444177012472	metal binding site [ion binding]; metal-binding site
444177012473	putative Cl binding site [ion binding]; other site
444177012474	aspartate ring; other site
444177012475	basic sphincter; other site
444177012476	hydrophobic gate; other site
444177012477	periplasmic entrance; other site
444177012478	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
444177012479	heme-binding site [chemical binding]; other site
444177012480	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177012481	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177012482	dimer interface [polypeptide binding]; other site
444177012483	putative CheW interface [polypeptide binding]; other site
444177012484	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
444177012485	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
444177012486	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
444177012487	NAD(P) binding site [chemical binding]; other site
444177012488	catalytic residues [active]
444177012489	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
444177012490	Protein of unknown function (DUF779); Region: DUF779; pfam05610
444177012491	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
444177012492	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
444177012493	NAD(P) binding site [chemical binding]; other site
444177012494	catalytic residues [active]
444177012495	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
444177012496	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
444177012497	RNA binding surface [nucleotide binding]; other site
444177012498	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
444177012499	probable active site [active]
444177012500	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
444177012501	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
444177012502	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
444177012503	Walker A/P-loop; other site
444177012504	ATP binding site [chemical binding]; other site
444177012505	Q-loop/lid; other site
444177012506	ABC transporter signature motif; other site
444177012507	Walker B; other site
444177012508	D-loop; other site
444177012509	H-loop/switch region; other site
444177012510	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
444177012511	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
444177012512	Walker A/P-loop; other site
444177012513	ATP binding site [chemical binding]; other site
444177012514	Q-loop/lid; other site
444177012515	ABC transporter signature motif; other site
444177012516	Walker B; other site
444177012517	D-loop; other site
444177012518	H-loop/switch region; other site
444177012519	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
444177012520	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
444177012521	TM-ABC transporter signature motif; other site
444177012522	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
444177012523	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
444177012524	TM-ABC transporter signature motif; other site
444177012525	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
444177012526	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
444177012527	putative ligand binding site [chemical binding]; other site
444177012528	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177012529	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13315
444177012530	Predicted membrane protein [Function unknown]; Region: COG2855
444177012531	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177012532	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177012533	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
444177012534	putative dimerization interface [polypeptide binding]; other site
444177012535	Transcriptional regulator [Transcription]; Region: LysR; COG0583
444177012536	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
444177012537	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
444177012538	dimerization interface [polypeptide binding]; other site
444177012539	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
444177012540	RNA ligase; Region: RNA_ligase; pfam09414
444177012541	AAA domain; Region: AAA_33; pfam13671
444177012542	AAA domain; Region: AAA_17; pfam13207
444177012543	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
444177012544	Zn2+ binding site [ion binding]; other site
444177012545	Mg2+ binding site [ion binding]; other site
444177012546	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
444177012547	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
444177012548	metal binding site [ion binding]; metal-binding site
444177012549	dimer interface [polypeptide binding]; other site
444177012550	Predicted membrane protein [Function unknown]; Region: COG1288
444177012551	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
444177012552	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
444177012553	Part of AAA domain; Region: AAA_19; pfam13245
444177012554	Family description; Region: UvrD_C_2; pfam13538
444177012555	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
444177012556	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
444177012557	Walker A/P-loop; other site
444177012558	ATP binding site [chemical binding]; other site
444177012559	Q-loop/lid; other site
444177012560	ABC transporter signature motif; other site
444177012561	Walker B; other site
444177012562	D-loop; other site
444177012563	H-loop/switch region; other site
444177012564	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
444177012565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177012566	ABC-ATPase subunit interface; other site
444177012567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
444177012568	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
444177012569	dimer interface [polypeptide binding]; other site
444177012570	conserved gate region; other site
444177012571	putative PBP binding loops; other site
444177012572	ABC-ATPase subunit interface; other site
444177012573	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
444177012574	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
444177012575	substrate binding pocket [chemical binding]; other site
444177012576	membrane-bound complex binding site; other site
444177012577	hinge residues; other site
444177012578	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
444177012579	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
444177012580	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
444177012581	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177012582	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
444177012583	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
444177012584	Cache domain; Region: Cache_1; pfam02743
444177012585	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177012586	dimerization interface [polypeptide binding]; other site
444177012587	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177012588	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177012589	dimer interface [polypeptide binding]; other site
444177012590	putative CheW interface [polypeptide binding]; other site
444177012591	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
444177012592	Cache domain; Region: Cache_1; pfam02743
444177012593	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177012594	dimerization interface [polypeptide binding]; other site
444177012595	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177012596	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177012597	dimer interface [polypeptide binding]; other site
444177012598	putative CheW interface [polypeptide binding]; other site
444177012599	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
444177012600	dimer interface [polypeptide binding]; other site
444177012601	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
444177012602	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
444177012603	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
444177012604	active site
444177012605	Cache domain; Region: Cache_2; cl07034
444177012606	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177012607	dimerization interface [polypeptide binding]; other site
444177012608	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
444177012609	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177012610	dimer interface [polypeptide binding]; other site
444177012611	putative CheW interface [polypeptide binding]; other site
444177012612	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
444177012613	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
444177012614	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
444177012615	Sterol carrier protein domain; Region: SCP2_2; pfam13530
444177012616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177012617	active site
444177012618	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
444177012619	phosphorylation site [posttranslational modification]
444177012620	intermolecular recognition site; other site
444177012621	dimerization interface [polypeptide binding]; other site
444177012622	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
444177012623	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
444177012624	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
444177012625	CHASE3 domain; Region: CHASE3; pfam05227
444177012626	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
444177012627	dimerization interface [polypeptide binding]; other site
444177012628	GAF domain; Region: GAF; pfam01590
444177012629	GAF domain; Region: GAF_2; pfam13185
444177012630	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
444177012631	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177012632	dimer interface [polypeptide binding]; other site
444177012633	phosphorylation site [posttranslational modification]
444177012634	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177012635	ATP binding site [chemical binding]; other site
444177012636	Mg2+ binding site [ion binding]; other site
444177012637	G-X-G motif; other site
444177012638	Response regulator receiver domain; Region: Response_reg; pfam00072
444177012639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177012640	active site
444177012641	phosphorylation site [posttranslational modification]
444177012642	intermolecular recognition site; other site
444177012643	dimerization interface [polypeptide binding]; other site
444177012644	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177012645	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177012646	Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229
444177012647	putative active site [active]
444177012648	Zn binding site [ion binding]; other site
444177012649	Predicted transcriptional regulators [Transcription]; Region: COG1695
444177012650	Transcriptional regulator PadR-like family; Region: PadR; cl17335
444177012651	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
444177012652	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
444177012653	MarR family; Region: MarR; pfam01047
444177012654	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
444177012655	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
444177012656	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
444177012657	malate:quinone oxidoreductase; Validated; Region: PRK05257
444177012658	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
444177012659	Transcriptional regulators [Transcription]; Region: GntR; COG1802
444177012660	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177012661	DNA-binding site [nucleotide binding]; DNA binding site
444177012662	FCD domain; Region: FCD; pfam07729
444177012663	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
444177012664	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
444177012665	N- and C-terminal domain interface [polypeptide binding]; other site
444177012666	active site
444177012667	catalytic site [active]
444177012668	metal binding site [ion binding]; metal-binding site
444177012669	carbohydrate binding site [chemical binding]; other site
444177012670	ATP binding site [chemical binding]; other site
444177012671	fructuronate transporter; Provisional; Region: PRK10034; cl15264
444177012672	gluconate transporter; Region: gntP; TIGR00791
444177012673	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
444177012674	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
444177012675	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
444177012676	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177012677	sensory histidine kinase AtoS; Provisional; Region: PRK11360
444177012678	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
444177012679	Dimer interface [polypeptide binding]; other site
444177012680	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
444177012681	active site
444177012682	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
444177012683	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
444177012684	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
444177012685	GAF domain; Region: GAF; pfam01590
444177012686	PAS domain S-box; Region: sensory_box; TIGR00229
444177012687	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177012688	putative active site [active]
444177012689	heme pocket [chemical binding]; other site
444177012690	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
444177012691	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
444177012692	metal binding site [ion binding]; metal-binding site
444177012693	active site
444177012694	I-site; other site
444177012695	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
444177012696	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
444177012697	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
444177012698	PYR/PP interface [polypeptide binding]; other site
444177012699	dimer interface [polypeptide binding]; other site
444177012700	TPP binding site [chemical binding]; other site
444177012701	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
444177012702	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
444177012703	TPP-binding site [chemical binding]; other site
444177012704	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
444177012705	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
444177012706	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
444177012707	FMN binding site [chemical binding]; other site
444177012708	active site
444177012709	catalytic residues [active]
444177012710	substrate binding site [chemical binding]; other site
444177012711	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
444177012712	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
444177012713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
444177012714	putative substrate translocation pore; other site
444177012715	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
444177012716	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
444177012717	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
444177012718	putative active site [active]
444177012719	catalytic triad [active]
444177012720	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
444177012721	PA/protease domain interface [polypeptide binding]; other site
444177012722	putative integrin binding motif; other site
444177012723	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
444177012724	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
444177012725	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177012726	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177012727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
444177012728	Staygreen protein; Region: Staygreen; pfam12638
444177012729	Proline dehydrogenase; Region: Pro_dh; cl03282
444177012730	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
444177012731	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
444177012732	DNA-binding site [nucleotide binding]; DNA binding site
444177012733	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
444177012734	pyridoxal 5'-phosphate binding site [chemical binding]; other site
444177012735	homodimer interface [polypeptide binding]; other site
444177012736	catalytic residue [active]
444177012737	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
444177012738	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177012739	dimerization interface [polypeptide binding]; other site
444177012740	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
444177012741	dimer interface [polypeptide binding]; other site
444177012742	putative CheW interface [polypeptide binding]; other site
444177012743	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
444177012744	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
444177012745	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
444177012746	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
444177012747	catalytic residues [active]
444177012748	catalytic nucleophile [active]
444177012749	Recombinase; Region: Recombinase; pfam07508
444177012750	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
444177012751	D5 N terminal like; Region: D5_N; smart00885
444177012752	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
444177012753	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
444177012754	F0F1-type ATP synthase, alpha subunit [Energy production and conversion]; Region: AtpA; COG0056
444177012755	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
444177012756	YyzF-like protein; Region: YyzF; pfam14116
444177012757	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
444177012758	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
444177012759	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
444177012760	protein binding site [polypeptide binding]; other site
444177012761	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
444177012762	YycH protein; Region: YycI; pfam09648
444177012763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
444177012764	YycH protein; Region: YycH; pfam07435
444177012765	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
444177012766	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
444177012767	dimerization interface [polypeptide binding]; other site
444177012768	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
444177012769	putative active site [active]
444177012770	heme pocket [chemical binding]; other site
444177012771	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
444177012772	dimer interface [polypeptide binding]; other site
444177012773	phosphorylation site [posttranslational modification]
444177012774	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
444177012775	ATP binding site [chemical binding]; other site
444177012776	Mg2+ binding site [ion binding]; other site
444177012777	G-X-G motif; other site
444177012778	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
444177012779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
444177012780	active site
444177012781	phosphorylation site [posttranslational modification]
444177012782	intermolecular recognition site; other site
444177012783	dimerization interface [polypeptide binding]; other site
444177012784	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
444177012785	DNA binding site [nucleotide binding]
444177012786	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
444177012787	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
444177012788	G5 domain; Region: G5; pfam07501
444177012789	Peptidase family M23; Region: Peptidase_M23; pfam01551
444177012790	Uncharacterized conserved protein [Function unknown]; Region: COG1284
444177012791	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
444177012792	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
444177012793	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
444177012794	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
444177012795	GDP-binding site [chemical binding]; other site
444177012796	ACT binding site; other site
444177012797	IMP binding site; other site
444177012798	replicative DNA helicase; Provisional; Region: PRK05748
444177012799	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
444177012800	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
444177012801	Walker A motif; other site
444177012802	ATP binding site [chemical binding]; other site
444177012803	Walker B motif; other site
444177012804	DNA binding loops [nucleotide binding]
444177012805	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
444177012806	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
444177012807	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
444177012808	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
444177012809	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
444177012810	DHH family; Region: DHH; pfam01368
444177012811	DHHA1 domain; Region: DHHA1; pfam02272
444177012812	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
444177012813	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
444177012814	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
444177012815	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
444177012816	dimer interface [polypeptide binding]; other site
444177012817	ssDNA binding site [nucleotide binding]; other site
444177012818	tetramer (dimer of dimers) interface [polypeptide binding]; other site
444177012819	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
444177012820	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
444177012821	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
444177012822	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
444177012823	active site
444177012824	GTP-binding protein YchF; Reviewed; Region: PRK09601
444177012825	YchF GTPase; Region: YchF; cd01900
444177012826	G1 box; other site
444177012827	GTP/Mg2+ binding site [chemical binding]; other site
444177012828	Switch I region; other site
444177012829	G2 box; other site
444177012830	Switch II region; other site
444177012831	G3 box; other site
444177012832	G4 box; other site
444177012833	G5 box; other site
444177012834	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
444177012835	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
444177012836	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
444177012837	Mechanosensitive ion channel; Region: MS_channel; pfam00924
444177012838	Protein of unknown function (DUF554); Region: DUF554; pfam04474
444177012839	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
444177012840	ParB-like nuclease domain; Region: ParB; smart00470
444177012841	KorB domain; Region: KorB; pfam08535
444177012842	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
444177012843	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
444177012844	P-loop; other site
444177012845	Magnesium ion binding site [ion binding]; other site
444177012846	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
444177012847	ParB-like nuclease domain; Region: ParBc; pfam02195
444177012848	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
444177012849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
444177012850	S-adenosylmethionine binding site [chemical binding]; other site
444177012851	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
444177012852	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
444177012853	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
444177012854	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
444177012855	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
444177012856	trmE is a tRNA modification GTPase; Region: trmE; cd04164
444177012857	G1 box; other site
444177012858	GTP/Mg2+ binding site [chemical binding]; other site
444177012859	Switch I region; other site
444177012860	G2 box; other site
444177012861	Switch II region; other site
444177012862	G3 box; other site
444177012863	G4 box; other site
444177012864	G5 box; other site
444177012865	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
444177012866	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
444177012867	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
444177012868	G-X-X-G motif; other site
444177012869	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
444177012870	RxxxH motif; other site
444177012871	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
444177012872	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
444177012873	ribonuclease P; Reviewed; Region: rnpA; PRK00499
444177012874	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399