-- dump date 20140619_134846 -- class Genbank::misc_feature -- table misc_feature_note -- id note 156889000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 156889000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 156889000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889000004 Walker A motif; other site 156889000005 ATP binding site [chemical binding]; other site 156889000006 Walker B motif; other site 156889000007 arginine finger; other site 156889000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 156889000009 DnaA box-binding interface [nucleotide binding]; other site 156889000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 156889000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 156889000012 putative DNA binding surface [nucleotide binding]; other site 156889000013 dimer interface [polypeptide binding]; other site 156889000014 beta-clamp/clamp loader binding surface; other site 156889000015 beta-clamp/translesion DNA polymerase binding surface; other site 156889000016 recombination protein F; Reviewed; Region: recF; PRK00064 156889000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889000018 Walker A/P-loop; other site 156889000019 ATP binding site [chemical binding]; other site 156889000020 Q-loop/lid; other site 156889000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889000022 ABC transporter signature motif; other site 156889000023 Walker B; other site 156889000024 D-loop; other site 156889000025 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 156889000026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889000027 Walker A/P-loop; other site 156889000028 ATP binding site [chemical binding]; other site 156889000029 TIGR02646 family protein; Region: TIGR02646 156889000030 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 156889000031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889000032 Mg2+ binding site [ion binding]; other site 156889000033 G-X-G motif; other site 156889000034 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 156889000035 anchoring element; other site 156889000036 dimer interface [polypeptide binding]; other site 156889000037 ATP binding site [chemical binding]; other site 156889000038 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 156889000039 active site 156889000040 putative metal-binding site [ion binding]; other site 156889000041 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 156889000042 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 156889000043 flagellar biosynthetic protein FliQ; Region: fliQ; TIGR01402 156889000044 flagellar biosynthetic protein FliR; Region: fliR; TIGR01400 156889000045 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 156889000046 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 156889000047 recombination regulator RecX; Reviewed; Region: recX; PRK00117 156889000048 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 156889000049 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 156889000050 motif 1; other site 156889000051 active site 156889000052 motif 2; other site 156889000053 motif 3; other site 156889000054 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 156889000055 DHHA1 domain; Region: DHHA1; pfam02272 156889000056 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 156889000057 dimer interface [polypeptide binding]; other site 156889000058 substrate binding site [chemical binding]; other site 156889000059 ATP binding site [chemical binding]; other site 156889000060 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 156889000061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889000062 Walker A motif; other site 156889000063 ATP binding site [chemical binding]; other site 156889000064 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 156889000065 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 156889000066 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889000067 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889000068 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 156889000069 active site 156889000070 HslU subunit interaction site [polypeptide binding]; other site 156889000071 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 156889000072 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 156889000073 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 156889000074 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 156889000075 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 156889000076 CoA-binding site [chemical binding]; other site 156889000077 ATP-binding [chemical binding]; other site 156889000078 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 156889000079 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 156889000080 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 156889000081 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 156889000082 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 156889000083 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 156889000084 shikimate binding site; other site 156889000085 NAD(P) binding site [chemical binding]; other site 156889000086 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 156889000087 Uncharacterized conserved protein [Function unknown]; Region: COG0327 156889000088 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 156889000089 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 156889000090 substrate binding site [chemical binding]; other site 156889000091 active site 156889000092 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 156889000093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889000094 FeS/SAM binding site; other site 156889000095 HemN C-terminal domain; Region: HemN_C; pfam06969 156889000096 protoporphyrinogen oxidase; Region: PLN02576 156889000097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 156889000098 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 156889000099 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 156889000100 active site 156889000101 catalytic site [active] 156889000102 substrate binding site [chemical binding]; other site 156889000103 Cytochrome c; Region: Cytochrom_C; cl11414 156889000104 Cytochrome c; Region: Cytochrom_C; cl11414 156889000105 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 156889000106 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 156889000107 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 156889000108 catalytic residue [active] 156889000109 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 156889000110 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 156889000111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 156889000112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889000113 S-adenosylmethionine binding site [chemical binding]; other site 156889000114 biotin synthase; Region: bioB; TIGR00433 156889000115 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889000116 FeS/SAM binding site; other site 156889000117 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 156889000118 AAA domain; Region: AAA_26; pfam13500 156889000119 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 156889000120 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 156889000121 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 156889000122 inhibitor-cofactor binding pocket; inhibition site 156889000123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889000124 catalytic residue [active] 156889000125 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 156889000126 pantoate--beta-alanine ligase; Region: panC; TIGR00018 156889000127 Pantoate-beta-alanine ligase; Region: PanC; cd00560 156889000128 active site 156889000129 ATP-binding site [chemical binding]; other site 156889000130 pantoate-binding site; other site 156889000131 HXXH motif; other site 156889000132 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 156889000133 oligomerization interface [polypeptide binding]; other site 156889000134 active site 156889000135 metal binding site [ion binding]; metal-binding site 156889000136 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]; Region: FolK; COG0801 156889000137 catalytic center binding site [active] 156889000138 ATP binding site [chemical binding]; other site 156889000139 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 156889000140 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 156889000141 putative active site [active] 156889000142 Zn binding site [ion binding]; other site 156889000143 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 156889000144 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 156889000145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889000146 homodimer interface [polypeptide binding]; other site 156889000147 catalytic residue [active] 156889000148 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 156889000149 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 156889000150 trimer interface [polypeptide binding]; other site 156889000151 active site 156889000152 substrate binding site [chemical binding]; other site 156889000153 CoA binding site [chemical binding]; other site 156889000154 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 156889000155 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 156889000156 metal binding site [ion binding]; metal-binding site 156889000157 dimer interface [polypeptide binding]; other site 156889000158 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 156889000159 dimer interface [polypeptide binding]; other site 156889000160 [2Fe-2S] cluster binding site [ion binding]; other site 156889000161 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 156889000162 DsrC like protein; Region: DsrC; pfam04358 156889000163 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 156889000164 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 156889000165 ribonuclease PH; Reviewed; Region: rph; PRK00173 156889000166 Ribonuclease PH; Region: RNase_PH_bact; cd11362 156889000167 hexamer interface [polypeptide binding]; other site 156889000168 active site 156889000169 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 156889000170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889000171 FeS/SAM binding site; other site 156889000172 HemN C-terminal domain; Region: HemN_C; pfam06969 156889000173 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889000174 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 156889000175 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889000176 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889000177 dimer interface [polypeptide binding]; other site 156889000178 putative CheW interface [polypeptide binding]; other site 156889000179 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 156889000180 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 156889000181 hexamer interface [polypeptide binding]; other site 156889000182 ligand binding site [chemical binding]; other site 156889000183 putative active site [active] 156889000184 NAD(P) binding site [chemical binding]; other site 156889000185 Peptidase family M48; Region: Peptidase_M48; cl12018 156889000186 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889000187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889000188 TPR motif; other site 156889000189 binding surface 156889000190 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 156889000191 Uncharacterized conserved protein [Function unknown]; Region: COG3334 156889000192 flagellin; Provisional; Region: PRK12802 156889000193 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000194 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000195 flagellin; Provisional; Region: PRK12802 156889000196 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000197 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000198 flagellin; Provisional; Region: PRK12802 156889000199 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000200 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000201 flagellin; Provisional; Region: PRK12802 156889000202 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000203 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000204 flagellin; Provisional; Region: PRK12802 156889000205 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000206 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000207 flagellin; Provisional; Region: PRK12802 156889000208 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000209 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000210 flagellin; Provisional; Region: PRK12802 156889000211 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000212 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000213 flagellin; Provisional; Region: PRK12802 156889000214 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000215 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000216 flagellin; Provisional; Region: PRK12802 156889000217 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000218 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000219 flagellin; Provisional; Region: PRK12802 156889000220 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000221 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000222 flagellin; Provisional; Region: PRK12802 156889000223 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000224 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000225 flagellin; Provisional; Region: PRK12802 156889000226 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000227 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000228 flagellin; Provisional; Region: PRK12804 156889000229 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000230 flagellin; Provisional; Region: PRK12802 156889000231 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000232 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000233 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 156889000234 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 156889000235 active site 156889000236 dimerization interface [polypeptide binding]; other site 156889000237 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 156889000238 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 156889000239 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000240 flagellar assembly protein FliW; Provisional; Region: PRK13285 156889000241 flagellin; Provisional; Region: PRK12802 156889000242 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889000243 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889000244 FlaG protein; Region: FlaG; pfam03646 156889000245 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 156889000246 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 156889000247 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 156889000248 Flagellar protein FliS; Region: FliS; cl00654 156889000249 Flagellar protein FliS; Region: FliS; cl00654 156889000250 shikimate kinase; Reviewed; Region: aroK; PRK00131 156889000251 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 156889000252 ADP binding site [chemical binding]; other site 156889000253 magnesium binding site [ion binding]; other site 156889000254 putative shikimate binding site; other site 156889000255 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889000256 IHF - DNA interface [nucleotide binding]; other site 156889000257 IHF dimer interface [polypeptide binding]; other site 156889000258 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 156889000259 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 156889000260 inhibitor-cofactor binding pocket; inhibition site 156889000261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889000262 catalytic residue [active] 156889000263 PilZ domain; Region: PilZ; pfam07238 156889000264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 156889000265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889000266 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 156889000267 Walker A motif; other site 156889000268 ATP binding site [chemical binding]; other site 156889000269 Walker B motif; other site 156889000270 arginine finger; other site 156889000271 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 156889000272 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 156889000273 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 156889000274 FAD binding pocket [chemical binding]; other site 156889000275 FAD binding motif [chemical binding]; other site 156889000276 phosphate binding motif [ion binding]; other site 156889000277 beta-alpha-beta structure motif; other site 156889000278 NAD binding pocket [chemical binding]; other site 156889000279 Iron coordination center [ion binding]; other site 156889000280 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 156889000281 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 156889000282 dihydroorotase; Validated; Region: pyrC; PRK09357 156889000283 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 156889000284 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 156889000285 active site 156889000286 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 156889000287 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 156889000288 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 156889000289 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 156889000290 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 156889000291 active site 156889000292 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 156889000293 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 156889000294 dimer interface [polypeptide binding]; other site 156889000295 ADP-ribose binding site [chemical binding]; other site 156889000296 active site 156889000297 nudix motif; other site 156889000298 metal binding site [ion binding]; metal-binding site 156889000299 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 156889000300 Protein of unknown function, DUF288; Region: DUF288; pfam03385 156889000301 Predicted permeases [General function prediction only]; Region: COG0701 156889000302 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 156889000303 Predicted ATPase [General function prediction only]; Region: COG4637 156889000304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889000305 Walker A/P-loop; other site 156889000306 ATP binding site [chemical binding]; other site 156889000307 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 156889000308 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889000309 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 156889000310 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 156889000311 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 156889000312 4Fe-4S binding domain; Region: Fer4_5; pfam12801 156889000313 MoxR-like ATPases [General function prediction only]; Region: COG0714 156889000314 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 156889000315 Walker A motif; other site 156889000316 ATP binding site [chemical binding]; other site 156889000317 Walker B motif; other site 156889000318 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 156889000319 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 156889000320 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 156889000321 D-pathway; other site 156889000322 Low-spin heme binding site [chemical binding]; other site 156889000323 Putative water exit pathway; other site 156889000324 Binuclear center (active site) [active] 156889000325 K-pathway; other site 156889000326 Putative proton exit pathway; other site 156889000327 Cytochrome c; Region: Cytochrom_C; pfam00034 156889000328 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 156889000329 elongation factor G; Reviewed; Region: PRK12740 156889000330 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 156889000331 putative GEF interaction site [polypeptide binding]; other site 156889000332 Switch I region; other site 156889000333 GTP/Mg2+ binding site [chemical binding]; other site 156889000334 G2 box; other site 156889000335 G3 box; other site 156889000336 Switch II region; other site 156889000337 G4 box; other site 156889000338 G5 box; other site 156889000339 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 156889000340 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 156889000341 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 156889000342 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 156889000343 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 156889000344 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 156889000345 Protein of unknown function, DUF486; Region: DUF486; cl01236 156889000346 HsdM N-terminal domain; Region: HsdM_N; pfam12161 156889000347 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 156889000348 Methyltransferase domain; Region: Methyltransf_26; pfam13659 156889000349 AAA domain; Region: AAA_13; pfam13166 156889000350 Virulence protein [General function prediction only]; Region: COG3943 156889000351 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 156889000352 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 156889000353 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 156889000354 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 156889000355 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 156889000356 BRO family, N-terminal domain; Region: Bro-N; pfam02498 156889000357 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 156889000358 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 156889000359 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889000360 ATP binding site [chemical binding]; other site 156889000361 putative Mg++ binding site [ion binding]; other site 156889000362 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 156889000363 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 156889000364 DNA binding site [nucleotide binding] 156889000365 active site 156889000366 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 156889000367 transcription termination factor Rho; Provisional; Region: rho; PRK09376 156889000368 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 156889000369 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 156889000370 RNA binding site [nucleotide binding]; other site 156889000371 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 156889000372 multimer interface [polypeptide binding]; other site 156889000373 Walker A motif; other site 156889000374 ATP binding site [chemical binding]; other site 156889000375 Walker B motif; other site 156889000376 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 156889000377 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 156889000378 Permutation of conserved domain; other site 156889000379 active site 156889000380 ferredoxin-NADP reductase; Provisional; Region: PRK10926 156889000381 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 156889000382 FAD binding pocket [chemical binding]; other site 156889000383 FAD binding motif [chemical binding]; other site 156889000384 phosphate binding motif [ion binding]; other site 156889000385 beta-alpha-beta structure motif; other site 156889000386 NAD binding pocket [chemical binding]; other site 156889000387 Stringent starvation protein B; Region: SspB; cl01120 156889000388 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 156889000389 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 156889000390 active site 156889000391 catalytic residues [active] 156889000392 metal binding site [ion binding]; metal-binding site 156889000393 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 156889000394 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 156889000395 putative active site [active] 156889000396 substrate binding site [chemical binding]; other site 156889000397 putative cosubstrate binding site; other site 156889000398 catalytic site [active] 156889000399 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 156889000400 substrate binding site [chemical binding]; other site 156889000401 M48 family peptidase; Provisional; Region: PRK03001 156889000402 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 156889000403 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 156889000404 Clp amino terminal domain; Region: Clp_N; pfam02861 156889000405 Clp amino terminal domain; Region: Clp_N; pfam02861 156889000406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889000407 Walker A motif; other site 156889000408 ATP binding site [chemical binding]; other site 156889000409 Walker B motif; other site 156889000410 arginine finger; other site 156889000411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889000412 Walker A motif; other site 156889000413 ATP binding site [chemical binding]; other site 156889000414 Walker B motif; other site 156889000415 arginine finger; other site 156889000416 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 156889000417 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 156889000418 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u2_5s; cd10971 156889000419 putative active site [active] 156889000420 putative metal binding site [ion binding]; other site 156889000421 FkbH-like domain; Region: FkbH; TIGR01686 156889000422 Acid Phosphatase; Region: Acid_PPase; cl17256 156889000423 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889000424 anti sigma factor interaction site; other site 156889000425 regulatory phosphorylation site [posttranslational modification]; other site 156889000426 PilZ domain; Region: PilZ; pfam07238 156889000427 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 156889000428 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 156889000429 tetratricopeptide repeat protein; Provisional; Region: PRK11788 156889000430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889000431 binding surface 156889000432 TPR motif; other site 156889000433 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 156889000434 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 156889000435 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 156889000436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 156889000437 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 156889000438 NAD(P) binding site [chemical binding]; other site 156889000439 active site 156889000440 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 156889000441 AIR carboxylase; Region: AIRC; smart01001 156889000442 thiamine monophosphate kinase; Provisional; Region: PRK05731 156889000443 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 156889000444 ATP binding site [chemical binding]; other site 156889000445 dimerization interface [polypeptide binding]; other site 156889000446 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 156889000447 putative RNA binding site [nucleotide binding]; other site 156889000448 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 156889000449 homopentamer interface [polypeptide binding]; other site 156889000450 active site 156889000451 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 156889000452 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 156889000453 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 156889000454 dimerization interface [polypeptide binding]; other site 156889000455 active site 156889000456 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 156889000457 Lumazine binding domain; Region: Lum_binding; pfam00677 156889000458 Lumazine binding domain; Region: Lum_binding; pfam00677 156889000459 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 156889000460 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 156889000461 catalytic motif [active] 156889000462 Zn binding site [ion binding]; other site 156889000463 RibD C-terminal domain; Region: RibD_C; cl17279 156889000464 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 156889000465 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 156889000466 dimer interface [polypeptide binding]; other site 156889000467 active site 156889000468 glycine-pyridoxal phosphate binding site [chemical binding]; other site 156889000469 folate binding site [chemical binding]; other site 156889000470 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 156889000471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889000472 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 156889000473 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 156889000474 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 156889000475 RNA binding site [nucleotide binding]; other site 156889000476 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 156889000477 RNA binding site [nucleotide binding]; other site 156889000478 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 156889000479 RNA binding site [nucleotide binding]; other site 156889000480 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 156889000481 RNA binding site [nucleotide binding]; other site 156889000482 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 156889000483 RNA binding site [nucleotide binding]; other site 156889000484 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 156889000485 RNA binding site [nucleotide binding]; other site 156889000486 cytidylate kinase; Provisional; Region: cmk; PRK00023 156889000487 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 156889000488 CMP-binding site; other site 156889000489 The sites determining sugar specificity; other site 156889000490 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 156889000491 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 156889000492 hinge; other site 156889000493 active site 156889000494 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 156889000495 prephenate dehydrogenase; Validated; Region: PRK08507 156889000496 chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807 156889000497 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 156889000498 Prephenate dehydratase; Region: PDT; pfam00800 156889000499 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 156889000500 putative L-Phe binding site [chemical binding]; other site 156889000501 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 156889000502 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 156889000503 Atrophin-1 family; Region: Atrophin-1; pfam03154 156889000504 Outer membrane lipoprotein; Region: YfiO; pfam13525 156889000505 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 156889000506 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 156889000507 N-acetyl-D-glucosamine binding site [chemical binding]; other site 156889000508 catalytic residue [active] 156889000509 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 156889000510 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 156889000511 N-acetyl-D-glucosamine binding site [chemical binding]; other site 156889000512 catalytic residue [active] 156889000513 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 156889000514 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 156889000515 putative ligand binding site [chemical binding]; other site 156889000516 PAS domain S-box; Region: sensory_box; TIGR00229 156889000517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889000518 putative active site [active] 156889000519 heme pocket [chemical binding]; other site 156889000520 PAS fold; Region: PAS_3; pfam08447 156889000521 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 156889000522 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889000523 PAS domain; Region: PAS_9; pfam13426 156889000524 putative active site [active] 156889000525 heme pocket [chemical binding]; other site 156889000526 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889000527 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889000528 metal binding site [ion binding]; metal-binding site 156889000529 active site 156889000530 I-site; other site 156889000531 HAMP domain; Region: HAMP; pfam00672 156889000532 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889000533 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889000534 dimer interface [polypeptide binding]; other site 156889000535 putative CheW interface [polypeptide binding]; other site 156889000536 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889000537 Hemerythrin; Region: Hemerythrin; cd12107 156889000538 Fe binding site [ion binding]; other site 156889000539 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889000540 anti sigma factor interaction site; other site 156889000541 regulatory phosphorylation site [posttranslational modification]; other site 156889000542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889000543 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 156889000544 Walker A motif; other site 156889000545 ATP binding site [chemical binding]; other site 156889000546 Walker B motif; other site 156889000547 arginine finger; other site 156889000548 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 156889000549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889000550 Zn2+ binding site [ion binding]; other site 156889000551 Mg2+ binding site [ion binding]; other site 156889000552 Domain of unknown function DUF29; Region: DUF29; pfam01724 156889000553 Sel1-like repeats; Region: SEL1; smart00671 156889000554 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889000555 Sel1-like repeats; Region: SEL1; smart00671 156889000556 Sel1 repeat; Region: Sel1; cl02723 156889000557 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889000558 Sel1-like repeats; Region: SEL1; smart00671 156889000559 Sel1-like repeats; Region: SEL1; smart00671 156889000560 Sel1-like repeats; Region: SEL1; smart00671 156889000561 Sel1 repeat; Region: Sel1; cl02723 156889000562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889000563 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 156889000564 substrate binding pocket [chemical binding]; other site 156889000565 membrane-bound complex binding site; other site 156889000566 hinge residues; other site 156889000567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889000568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889000569 dimer interface [polypeptide binding]; other site 156889000570 phosphorylation site [posttranslational modification] 156889000571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889000572 ATP binding site [chemical binding]; other site 156889000573 Mg2+ binding site [ion binding]; other site 156889000574 G-X-G motif; other site 156889000575 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889000576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889000577 active site 156889000578 phosphorylation site [posttranslational modification] 156889000579 intermolecular recognition site; other site 156889000580 dimerization interface [polypeptide binding]; other site 156889000581 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 156889000582 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 156889000583 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 156889000584 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 156889000585 Domain of unknown function (DUF336); Region: DUF336; pfam03928 156889000586 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 156889000587 Mrr N-terminal domain; Region: Mrr_N; pfam14338 156889000588 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 156889000589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 156889000590 putative DNA binding site [nucleotide binding]; other site 156889000591 putative Zn2+ binding site [ion binding]; other site 156889000592 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 156889000593 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 156889000594 active site 156889000595 dimer interface [polypeptide binding]; other site 156889000596 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 156889000597 Ligand Binding Site [chemical binding]; other site 156889000598 Molecular Tunnel; other site 156889000599 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 156889000600 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 156889000601 ATP-grasp domain; Region: ATP-grasp_4; cl17255 156889000602 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 156889000603 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 156889000604 putative oligomer interface [polypeptide binding]; other site 156889000605 putative active site [active] 156889000606 metal binding site [ion binding]; metal-binding site 156889000607 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 156889000608 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 156889000609 Peptidase_C39 like family; Region: DUF3335; pfam11814 156889000610 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 156889000611 putative active site [active] 156889000612 Zn binding site [ion binding]; other site 156889000613 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 156889000614 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 156889000615 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 156889000616 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 156889000617 GAF domain; Region: GAF_3; pfam13492 156889000618 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 156889000619 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 156889000620 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 156889000621 active site 156889000622 metal binding site [ion binding]; metal-binding site 156889000623 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889000624 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889000625 MASE1; Region: MASE1; cl17823 156889000626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889000627 PAS fold; Region: PAS_3; pfam08447 156889000628 putative active site [active] 156889000629 heme pocket [chemical binding]; other site 156889000630 PAS domain S-box; Region: sensory_box; TIGR00229 156889000631 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889000632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889000633 putative active site [active] 156889000634 heme pocket [chemical binding]; other site 156889000635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889000636 dimer interface [polypeptide binding]; other site 156889000637 phosphorylation site [posttranslational modification] 156889000638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889000639 ATP binding site [chemical binding]; other site 156889000640 Mg2+ binding site [ion binding]; other site 156889000641 G-X-G motif; other site 156889000642 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889000643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889000644 active site 156889000645 phosphorylation site [posttranslational modification] 156889000646 intermolecular recognition site; other site 156889000647 dimerization interface [polypeptide binding]; other site 156889000648 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889000649 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889000650 ligand binding site [chemical binding]; other site 156889000651 flexible hinge region; other site 156889000652 PAS domain S-box; Region: sensory_box; TIGR00229 156889000653 PAS domain S-box; Region: sensory_box; TIGR00229 156889000654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889000655 putative active site [active] 156889000656 heme pocket [chemical binding]; other site 156889000657 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889000658 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889000659 metal binding site [ion binding]; metal-binding site 156889000660 active site 156889000661 I-site; other site 156889000662 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 156889000663 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 156889000664 minor groove reading motif; other site 156889000665 helix-hairpin-helix signature motif; other site 156889000666 substrate binding pocket [chemical binding]; other site 156889000667 active site 156889000668 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 156889000669 DNA binding and oxoG recognition site [nucleotide binding] 156889000670 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 156889000671 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 156889000672 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 156889000673 ApbE family; Region: ApbE; pfam02424 156889000674 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 156889000675 Chorismate lyase; Region: Chor_lyase; cl01230 156889000676 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 156889000677 Response regulator receiver domain; Region: Response_reg; pfam00072 156889000678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889000679 active site 156889000680 phosphorylation site [posttranslational modification] 156889000681 intermolecular recognition site; other site 156889000682 dimerization interface [polypeptide binding]; other site 156889000683 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 156889000684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 156889000685 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 156889000686 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 156889000687 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 156889000688 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 156889000689 catalytic residues [active] 156889000690 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 156889000691 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 156889000692 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 156889000693 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 156889000694 23S rRNA interface [nucleotide binding]; other site 156889000695 L3 interface [polypeptide binding]; other site 156889000696 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 156889000697 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 156889000698 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 156889000699 Ferredoxin [Energy production and conversion]; Region: COG1146 156889000700 hypothetical protein; Provisional; Region: PRK11820 156889000701 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 156889000702 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 156889000703 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 156889000704 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 156889000705 catalytic site [active] 156889000706 G-X2-G-X-G-K; other site 156889000707 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 156889000708 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 156889000709 HD domain; Region: HD_4; pfam13328 156889000710 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 156889000711 synthetase active site [active] 156889000712 NTP binding site [chemical binding]; other site 156889000713 metal binding site [ion binding]; metal-binding site 156889000714 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 156889000715 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 156889000716 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 156889000717 homotrimer interaction site [polypeptide binding]; other site 156889000718 putative active site [active] 156889000719 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 156889000720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889000721 substrate binding pocket [chemical binding]; other site 156889000722 membrane-bound complex binding site; other site 156889000723 hypothetical protein; Reviewed; Region: PRK00024 156889000724 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 156889000725 MPN+ (JAMM) motif; other site 156889000726 Zinc-binding site [ion binding]; other site 156889000727 replicative DNA helicase; Region: DnaB; TIGR00665 156889000728 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 156889000729 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 156889000730 Walker A motif; other site 156889000731 ATP binding site [chemical binding]; other site 156889000732 Walker B motif; other site 156889000733 DNA binding loops [nucleotide binding] 156889000734 alanine racemase; Reviewed; Region: alr; PRK00053 156889000735 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 156889000736 active site 156889000737 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 156889000738 dimer interface [polypeptide binding]; other site 156889000739 substrate binding site [chemical binding]; other site 156889000740 catalytic residues [active] 156889000741 NMT1/THI5 like; Region: NMT1; pfam09084 156889000742 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889000743 substrate binding pocket [chemical binding]; other site 156889000744 membrane-bound complex binding site; other site 156889000745 hinge residues; other site 156889000746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889000747 dimerization interface [polypeptide binding]; other site 156889000748 GAF domain; Region: GAF_2; pfam13185 156889000749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889000750 dimer interface [polypeptide binding]; other site 156889000751 phosphorylation site [posttranslational modification] 156889000752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889000753 ATP binding site [chemical binding]; other site 156889000754 Mg2+ binding site [ion binding]; other site 156889000755 G-X-G motif; other site 156889000756 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889000757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889000758 active site 156889000759 phosphorylation site [posttranslational modification] 156889000760 intermolecular recognition site; other site 156889000761 dimerization interface [polypeptide binding]; other site 156889000762 Sporulation related domain; Region: SPOR; pfam05036 156889000763 DNA repair protein RadA; Provisional; Region: PRK11823 156889000764 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 156889000765 Walker A motif/ATP binding site; other site 156889000766 ATP binding site [chemical binding]; other site 156889000767 Walker B motif; other site 156889000768 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 156889000769 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 156889000770 Colicin V production protein; Region: Colicin_V; pfam02674 156889000771 amidophosphoribosyltransferase; Provisional; Region: PRK09123 156889000772 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 156889000773 active site 156889000774 tetramer interface [polypeptide binding]; other site 156889000775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 156889000776 active site 156889000777 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 156889000778 flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395 156889000779 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 156889000780 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 156889000781 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 156889000782 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 156889000783 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 156889000784 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 156889000785 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 156889000786 MgtE intracellular N domain; Region: MgtE_N; cl15244 156889000787 FliG C-terminal domain; Region: FliG_C; pfam01706 156889000788 Flagellar assembly protein FliH; Region: FliH; pfam02108 156889000789 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 156889000790 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 156889000791 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 156889000792 Walker A motif/ATP binding site; other site 156889000793 Walker B motif; other site 156889000794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 156889000795 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 156889000796 NAD(P) binding site [chemical binding]; other site 156889000797 active site 156889000798 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 156889000799 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 156889000800 bacterial Hfq-like; Region: Hfq; cd01716 156889000801 hexamer interface [polypeptide binding]; other site 156889000802 Sm1 motif; other site 156889000803 RNA binding site [nucleotide binding]; other site 156889000804 Sm2 motif; other site 156889000805 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 156889000806 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 156889000807 HflX GTPase family; Region: HflX; cd01878 156889000808 G1 box; other site 156889000809 GTP/Mg2+ binding site [chemical binding]; other site 156889000810 Switch I region; other site 156889000811 G2 box; other site 156889000812 G3 box; other site 156889000813 Switch II region; other site 156889000814 G4 box; other site 156889000815 G5 box; other site 156889000816 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 156889000817 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 156889000818 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889000819 Zn2+ binding site [ion binding]; other site 156889000820 Mg2+ binding site [ion binding]; other site 156889000821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 156889000822 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 156889000823 Rubredoxin; Region: Rubredoxin; pfam00301 156889000824 iron binding site [ion binding]; other site 156889000825 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 156889000826 ArsC family; Region: ArsC; pfam03960 156889000827 catalytic residues [active] 156889000828 Predicted membrane protein [Function unknown]; Region: COG1238 156889000829 FOG: WD40 repeat [General function prediction only]; Region: COG2319 156889000830 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 156889000831 structural tetrad; other site 156889000832 Uncharacterized conserved protein [Function unknown]; Region: COG1262 156889000833 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 156889000834 Ferritin-like; Region: Ferritin-like; pfam12902 156889000835 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 156889000836 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 156889000837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889000838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889000839 binding surface 156889000840 TPR motif; other site 156889000841 TPR repeat; Region: TPR_11; pfam13414 156889000842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889000843 binding surface 156889000844 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889000845 TPR motif; other site 156889000846 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 156889000847 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 156889000848 ring oligomerisation interface [polypeptide binding]; other site 156889000849 ATP/Mg binding site [chemical binding]; other site 156889000850 stacking interactions; other site 156889000851 hinge regions; other site 156889000852 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 156889000853 oligomerisation interface [polypeptide binding]; other site 156889000854 mobile loop; other site 156889000855 roof hairpin; other site 156889000856 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 156889000857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889000858 dimer interface [polypeptide binding]; other site 156889000859 phosphorylation site [posttranslational modification] 156889000860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889000861 ATP binding site [chemical binding]; other site 156889000862 Mg2+ binding site [ion binding]; other site 156889000863 G-X-G motif; other site 156889000864 Response regulator receiver domain; Region: Response_reg; pfam00072 156889000865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889000866 active site 156889000867 phosphorylation site [posttranslational modification] 156889000868 intermolecular recognition site; other site 156889000869 dimerization interface [polypeptide binding]; other site 156889000870 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 156889000871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889000872 intermolecular recognition site; other site 156889000873 active site 156889000874 dimerization interface [polypeptide binding]; other site 156889000875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889000876 Walker A motif; other site 156889000877 ATP binding site [chemical binding]; other site 156889000878 Walker B motif; other site 156889000879 arginine finger; other site 156889000880 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 156889000881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889000882 binding surface 156889000883 TPR motif; other site 156889000884 TPR motif; other site 156889000885 Tetratricopeptide repeat; Region: TPR_1; pfam00515 156889000886 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 156889000887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889000888 Walker A motif; other site 156889000889 ATP binding site [chemical binding]; other site 156889000890 Walker B motif; other site 156889000891 arginine finger; other site 156889000892 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 156889000893 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 156889000894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889000895 S-adenosylmethionine binding site [chemical binding]; other site 156889000896 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889000897 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889000898 metal binding site [ion binding]; metal-binding site 156889000899 active site 156889000900 I-site; other site 156889000901 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 156889000902 active site lid residues [active] 156889000903 substrate binding pocket [chemical binding]; other site 156889000904 catalytic residues [active] 156889000905 substrate-Mg2+ binding site; other site 156889000906 aspartate-rich region 1; other site 156889000907 aspartate-rich region 2; other site 156889000908 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 156889000909 active site lid residues [active] 156889000910 substrate binding pocket [chemical binding]; other site 156889000911 catalytic residues [active] 156889000912 substrate-Mg2+ binding site; other site 156889000913 aspartate-rich region 1; other site 156889000914 aspartate-rich region 2; other site 156889000915 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 156889000916 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 156889000917 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 156889000918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 156889000919 binding surface 156889000920 TPR motif; other site 156889000921 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 156889000922 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889000923 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 156889000924 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889000925 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889000926 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889000927 dimer interface [polypeptide binding]; other site 156889000928 putative CheW interface [polypeptide binding]; other site 156889000929 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889000930 Hemerythrin; Region: Hemerythrin; cd12107 156889000931 Fe binding site [ion binding]; other site 156889000932 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889000933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889000934 ATP binding site [chemical binding]; other site 156889000935 G-X-G motif; other site 156889000936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 156889000937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889000938 active site 156889000939 phosphorylation site [posttranslational modification] 156889000940 intermolecular recognition site; other site 156889000941 dimerization interface [polypeptide binding]; other site 156889000942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 156889000943 DNA binding site [nucleotide binding] 156889000944 Predicted membrane protein [Function unknown]; Region: COG3212 156889000945 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 156889000946 Dihaem cytochrome c; Region: DHC; pfam09626 156889000947 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 156889000948 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 156889000949 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 156889000950 Part of AAA domain; Region: AAA_19; pfam13245 156889000951 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 156889000952 AAA domain; Region: AAA_12; pfam13087 156889000953 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 156889000954 putative active site [active] 156889000955 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 156889000956 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889000957 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889000958 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889000959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889000960 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889000961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889000962 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889000963 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889000964 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889000965 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889000966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889000967 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889000968 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889000969 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889000970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889000971 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 156889000972 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 156889000973 catalytic site [active] 156889000974 putative active site [active] 156889000975 putative substrate binding site [chemical binding]; other site 156889000976 short chain dehydrogenase; Provisional; Region: PRK09134 156889000977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 156889000978 NAD(P) binding site [chemical binding]; other site 156889000979 active site 156889000980 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 156889000981 homooctamer interface [polypeptide binding]; other site 156889000982 active site 156889000983 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 156889000984 catalytic center binding site [active] 156889000985 ATP binding site [chemical binding]; other site 156889000986 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 156889000987 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889000988 substrate binding pocket [chemical binding]; other site 156889000989 membrane-bound complex binding site; other site 156889000990 hinge residues; other site 156889000991 PAS domain; Region: PAS_8; pfam13188 156889000992 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889000993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889000994 dimer interface [polypeptide binding]; other site 156889000995 phosphorylation site [posttranslational modification] 156889000996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889000997 ATP binding site [chemical binding]; other site 156889000998 Mg2+ binding site [ion binding]; other site 156889000999 G-X-G motif; other site 156889001000 Response regulator receiver domain; Region: Response_reg; pfam00072 156889001001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889001002 active site 156889001003 phosphorylation site [posttranslational modification] 156889001004 intermolecular recognition site; other site 156889001005 dimerization interface [polypeptide binding]; other site 156889001006 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 156889001007 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 156889001008 active site 156889001009 substrate binding site [chemical binding]; other site 156889001010 metal binding site [ion binding]; metal-binding site 156889001011 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 156889001012 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 156889001013 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 156889001014 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 156889001015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 156889001016 Methyltransferase domain; Region: Methyltransf_23; pfam13489 156889001017 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 156889001018 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 156889001019 active site 156889001020 tetramer interface; other site 156889001021 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 156889001022 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 156889001023 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 156889001024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889001025 catalytic residue [active] 156889001026 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 156889001027 substrate binding site [chemical binding]; other site 156889001028 active site 156889001029 catalytic residues [active] 156889001030 heterodimer interface [polypeptide binding]; other site 156889001031 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 156889001032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889001033 active site 156889001034 phosphorylation site [posttranslational modification] 156889001035 intermolecular recognition site; other site 156889001036 dimerization interface [polypeptide binding]; other site 156889001037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889001038 Walker A motif; other site 156889001039 ATP binding site [chemical binding]; other site 156889001040 Walker B motif; other site 156889001041 arginine finger; other site 156889001042 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 156889001043 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 156889001044 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 156889001045 Sulfatase; Region: Sulfatase; pfam00884 156889001046 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 156889001047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889001048 non-specific DNA binding site [nucleotide binding]; other site 156889001049 salt bridge; other site 156889001050 sequence-specific DNA binding site [nucleotide binding]; other site 156889001051 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 156889001052 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 156889001053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889001054 catalytic residue [active] 156889001055 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 156889001056 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 156889001057 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 156889001058 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 156889001059 N-acetyl-D-glucosamine binding site [chemical binding]; other site 156889001060 catalytic residue [active] 156889001061 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 156889001062 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 156889001063 substrate binding site [chemical binding]; other site 156889001064 exopolyphosphatase; Region: exo_poly_only; TIGR03706 156889001065 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 156889001066 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 156889001067 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 156889001068 synthetase active site [active] 156889001069 NTP binding site [chemical binding]; other site 156889001070 metal binding site [ion binding]; metal-binding site 156889001071 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 156889001072 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 156889001073 putative GSH binding site [chemical binding]; other site 156889001074 catalytic residues [active] 156889001075 BolA-like protein; Region: BolA; cl00386 156889001076 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 156889001077 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 156889001078 Qi binding site; other site 156889001079 intrachain domain interface; other site 156889001080 interchain domain interface [polypeptide binding]; other site 156889001081 cytochrome b; Provisional; Region: CYTB; MTH00156 156889001082 heme bH binding site [chemical binding]; other site 156889001083 heme bL binding site [chemical binding]; other site 156889001084 Qo binding site; other site 156889001085 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 156889001086 interchain domain interface [polypeptide binding]; other site 156889001087 intrachain domain interface; other site 156889001088 Qi binding site; other site 156889001089 Qo binding site; other site 156889001090 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 156889001091 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 156889001092 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 156889001093 [2Fe-2S] cluster binding site [ion binding]; other site 156889001094 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 156889001095 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 156889001096 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 156889001097 active site 156889001098 substrate binding site [chemical binding]; other site 156889001099 metal binding site [ion binding]; metal-binding site 156889001100 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 156889001101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889001102 TPR motif; other site 156889001103 binding surface 156889001104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889001105 binding surface 156889001106 TPR motif; other site 156889001107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889001108 binding surface 156889001109 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889001110 TPR motif; other site 156889001111 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 156889001112 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 156889001113 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 156889001114 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 156889001115 active site 156889001116 dimer interface [polypeptide binding]; other site 156889001117 motif 1; other site 156889001118 motif 2; other site 156889001119 motif 3; other site 156889001120 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 156889001121 anticodon binding site; other site 156889001122 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 156889001123 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 156889001124 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 156889001125 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 156889001126 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 156889001127 23S rRNA binding site [nucleotide binding]; other site 156889001128 L21 binding site [polypeptide binding]; other site 156889001129 L13 binding site [polypeptide binding]; other site 156889001130 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 156889001131 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 156889001132 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 156889001133 dimer interface [polypeptide binding]; other site 156889001134 motif 1; other site 156889001135 active site 156889001136 motif 2; other site 156889001137 motif 3; other site 156889001138 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 156889001139 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 156889001140 putative tRNA-binding site [nucleotide binding]; other site 156889001141 B3/4 domain; Region: B3_4; pfam03483 156889001142 tRNA synthetase B5 domain; Region: B5; smart00874 156889001143 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 156889001144 dimer interface [polypeptide binding]; other site 156889001145 motif 1; other site 156889001146 motif 3; other site 156889001147 motif 2; other site 156889001148 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 156889001149 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 156889001150 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 156889001151 active site 156889001152 substrate-binding site [chemical binding]; other site 156889001153 metal-binding site [ion binding] 156889001154 ATP binding site [chemical binding]; other site 156889001155 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 156889001156 Peptidase family M23; Region: Peptidase_M23; pfam01551 156889001157 Predicted membrane protein [Function unknown]; Region: COG1238 156889001158 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 156889001159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889001160 S-adenosylmethionine binding site [chemical binding]; other site 156889001161 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 156889001162 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 156889001163 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 156889001164 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 156889001165 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 156889001166 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 156889001167 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 156889001168 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 156889001169 Walker A/P-loop; other site 156889001170 ATP binding site [chemical binding]; other site 156889001171 Q-loop/lid; other site 156889001172 ABC transporter signature motif; other site 156889001173 Walker B; other site 156889001174 D-loop; other site 156889001175 H-loop/switch region; other site 156889001176 antiporter inner membrane protein; Provisional; Region: PRK11670 156889001177 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 156889001178 Walker A motif; other site 156889001179 GTPase RsgA; Reviewed; Region: PRK01889 156889001180 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 156889001181 GTPase/Zn-binding domain interface [polypeptide binding]; other site 156889001182 GTP/Mg2+ binding site [chemical binding]; other site 156889001183 G4 box; other site 156889001184 G5 box; other site 156889001185 G1 box; other site 156889001186 Switch I region; other site 156889001187 G2 box; other site 156889001188 G3 box; other site 156889001189 Switch II region; other site 156889001190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 156889001191 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 156889001192 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 156889001193 acyl-activating enzyme (AAE) consensus motif; other site 156889001194 AMP binding site [chemical binding]; other site 156889001195 active site 156889001196 CoA binding site [chemical binding]; other site 156889001197 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 156889001198 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 156889001199 dimer interface [polypeptide binding]; other site 156889001200 substrate binding site [chemical binding]; other site 156889001201 metal binding site [ion binding]; metal-binding site 156889001202 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 156889001203 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 156889001204 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 156889001205 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 156889001206 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 156889001207 carboxyltransferase (CT) interaction site; other site 156889001208 biotinylation site [posttranslational modification]; other site 156889001209 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 156889001210 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 156889001211 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 156889001212 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 156889001213 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 156889001214 Walker A; other site 156889001215 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 156889001216 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 156889001217 active site 156889001218 substrate binding site [chemical binding]; other site 156889001219 coenzyme B12 binding site [chemical binding]; other site 156889001220 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 156889001221 B12 binding site [chemical binding]; other site 156889001222 cobalt ligand [ion binding]; other site 156889001223 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 156889001224 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889001225 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 156889001226 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 156889001227 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 156889001228 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 156889001229 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 156889001230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 156889001231 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 156889001232 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 156889001233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 156889001234 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 156889001235 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 156889001236 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 156889001237 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 156889001238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889001239 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 156889001240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 156889001241 Uncharacterized conserved protein [Function unknown]; Region: COG2308 156889001242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889001243 active site 156889001244 phosphorylation site [posttranslational modification] 156889001245 intermolecular recognition site; other site 156889001246 Hemerythrin; Region: Hemerythrin; cd12107 156889001247 Fe binding site [ion binding]; other site 156889001248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 156889001249 active site 156889001250 phosphorylation site [posttranslational modification] 156889001251 intermolecular recognition site; other site 156889001252 dimerization interface [polypeptide binding]; other site 156889001253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889001254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889001255 dimer interface [polypeptide binding]; other site 156889001256 phosphorylation site [posttranslational modification] 156889001257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889001258 ATP binding site [chemical binding]; other site 156889001259 Mg2+ binding site [ion binding]; other site 156889001260 G-X-G motif; other site 156889001261 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 156889001262 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889001263 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 156889001264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889001265 putative active site [active] 156889001266 heme pocket [chemical binding]; other site 156889001267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889001268 ATP binding site [chemical binding]; other site 156889001269 Mg2+ binding site [ion binding]; other site 156889001270 G-X-G motif; other site 156889001271 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889001272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889001273 metal binding site [ion binding]; metal-binding site 156889001274 active site 156889001275 I-site; other site 156889001276 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889001277 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 156889001278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889001279 S-adenosylmethionine binding site [chemical binding]; other site 156889001280 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 156889001281 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 156889001282 active site 156889001283 catalytic tetrad [active] 156889001284 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 156889001285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889001286 PAS domain; Region: PAS_9; pfam13426 156889001287 putative active site [active] 156889001288 heme pocket [chemical binding]; other site 156889001289 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889001290 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889001291 metal binding site [ion binding]; metal-binding site 156889001292 active site 156889001293 I-site; other site 156889001294 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889001295 HDOD domain; Region: HDOD; pfam08668 156889001296 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889001297 Zn2+ binding site [ion binding]; other site 156889001298 Mg2+ binding site [ion binding]; other site 156889001299 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 156889001300 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889001301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889001302 metal binding site [ion binding]; metal-binding site 156889001303 active site 156889001304 I-site; other site 156889001305 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889001306 anti sigma factor interaction site; other site 156889001307 regulatory phosphorylation site [posttranslational modification]; other site 156889001308 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 156889001309 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889001310 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 156889001311 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 156889001312 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 156889001313 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 156889001314 active site 156889001315 HIGH motif; other site 156889001316 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 156889001317 KMSKS motif; other site 156889001318 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 156889001319 tRNA binding surface [nucleotide binding]; other site 156889001320 anticodon binding site; other site 156889001321 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 156889001322 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 156889001323 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 156889001324 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 156889001325 Peptidase family M50; Region: Peptidase_M50; pfam02163 156889001326 active site 156889001327 putative substrate binding region [chemical binding]; other site 156889001328 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 156889001329 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889001330 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889001331 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 156889001332 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889001333 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 156889001334 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889001335 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 156889001336 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 156889001337 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 156889001338 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 156889001339 Ca2+ binding site [ion binding]; other site 156889001340 Cadherin repeat-like domain; Region: CA_like; cl15786 156889001341 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 156889001342 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889001343 Cadherin repeat-like domain; Region: CA_like; cl15786 156889001344 Ca2+ binding site [ion binding]; other site 156889001345 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 156889001346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 156889001347 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 156889001348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 156889001349 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 156889001350 PAS domain S-box; Region: sensory_box; TIGR00229 156889001351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889001352 putative active site [active] 156889001353 heme pocket [chemical binding]; other site 156889001354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889001355 dimer interface [polypeptide binding]; other site 156889001356 phosphorylation site [posttranslational modification] 156889001357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889001358 ATP binding site [chemical binding]; other site 156889001359 Mg2+ binding site [ion binding]; other site 156889001360 G-X-G motif; other site 156889001361 Response regulator receiver domain; Region: Response_reg; pfam00072 156889001362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889001363 active site 156889001364 phosphorylation site [posttranslational modification] 156889001365 intermolecular recognition site; other site 156889001366 dimerization interface [polypeptide binding]; other site 156889001367 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 156889001368 membrane-bound complex binding site; other site 156889001369 hinge residues; other site 156889001370 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 156889001371 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 156889001372 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 156889001373 substrate-cofactor binding pocket; other site 156889001374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889001375 catalytic residue [active] 156889001376 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 156889001377 Cysteine-rich domain; Region: CCG; pfam02754 156889001378 Cysteine-rich domain; Region: CCG; pfam02754 156889001379 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 156889001380 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 156889001381 L-aspartate oxidase; Provisional; Region: PRK06175 156889001382 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 156889001383 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 156889001384 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 156889001385 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 156889001386 HIGH motif; other site 156889001387 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 156889001388 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 156889001389 active site 156889001390 KMSKS motif; other site 156889001391 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 156889001392 tRNA binding surface [nucleotide binding]; other site 156889001393 Lipopolysaccharide-assembly; Region: LptE; cl01125 156889001394 Hpt domain; Region: Hpt; pfam01627 156889001395 putative binding surface; other site 156889001396 active site 156889001397 Response regulator receiver domain; Region: Response_reg; pfam00072 156889001398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889001399 active site 156889001400 phosphorylation site [posttranslational modification] 156889001401 intermolecular recognition site; other site 156889001402 dimerization interface [polypeptide binding]; other site 156889001403 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 156889001404 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 156889001405 Ligand Binding Site [chemical binding]; other site 156889001406 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 156889001407 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 156889001408 Ligand Binding Site [chemical binding]; other site 156889001409 Domain of unknown function (DUF3524); Region: DUF3524; pfam12038 156889001410 FtsH Extracellular; Region: FtsH_ext; pfam06480 156889001411 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 156889001412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889001413 Walker A motif; other site 156889001414 ATP binding site [chemical binding]; other site 156889001415 Walker B motif; other site 156889001416 arginine finger; other site 156889001417 Peptidase family M41; Region: Peptidase_M41; pfam01434 156889001418 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 156889001419 dihydropteroate synthase; Region: DHPS; TIGR01496 156889001420 substrate binding pocket [chemical binding]; other site 156889001421 dimer interface [polypeptide binding]; other site 156889001422 inhibitor binding site; inhibition site 156889001423 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889001424 anti sigma factor interaction site; other site 156889001425 regulatory phosphorylation site [posttranslational modification]; other site 156889001426 HAMP domain; Region: HAMP; pfam00672 156889001427 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889001428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889001429 dimer interface [polypeptide binding]; other site 156889001430 putative CheW interface [polypeptide binding]; other site 156889001431 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889001432 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889001433 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889001434 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 156889001435 Thioredoxin; Region: Thioredoxin_4; pfam13462 156889001436 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 156889001437 putative coenzyme Q binding site [chemical binding]; other site 156889001438 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 156889001439 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 156889001440 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 156889001441 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 156889001442 transmembrane helices; other site 156889001443 Citrate transporter; Region: CitMHS; pfam03600 156889001444 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 156889001445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 156889001446 active site 156889001447 motif I; other site 156889001448 motif II; other site 156889001449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 156889001450 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 156889001451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 156889001452 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 156889001453 putative dimerization interface [polypeptide binding]; other site 156889001454 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 156889001455 Domain of unknown function DUF21; Region: DUF21; pfam01595 156889001456 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 156889001457 Transporter associated domain; Region: CorC_HlyC; pfam03471 156889001458 Uncharacterized conserved protein [Function unknown]; Region: COG1434 156889001459 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 156889001460 putative active site [active] 156889001461 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 156889001462 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 156889001463 active site 156889001464 Int/Topo IB signature motif; other site 156889001465 Protein of unknown function, DUF484; Region: DUF484; cl17449 156889001466 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 156889001467 dimerization interface [polypeptide binding]; other site 156889001468 putative DNA binding site [nucleotide binding]; other site 156889001469 putative Zn2+ binding site [ion binding]; other site 156889001470 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 156889001471 active site residue [active] 156889001472 thioredoxin 2; Provisional; Region: PRK10996 156889001473 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 156889001474 catalytic residues [active] 156889001475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889001476 S-adenosylmethionine binding site [chemical binding]; other site 156889001477 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 156889001478 putative active site [active] 156889001479 putative metal binding residues [ion binding]; other site 156889001480 signature motif; other site 156889001481 putative triphosphate binding site [ion binding]; other site 156889001482 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 156889001483 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 156889001484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889001485 catalytic residue [active] 156889001486 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889001487 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889001488 ligand binding site [chemical binding]; other site 156889001489 flexible hinge region; other site 156889001490 putative switch regulator; other site 156889001491 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 156889001492 non-specific DNA interactions [nucleotide binding]; other site 156889001493 DNA binding site [nucleotide binding] 156889001494 sequence specific DNA binding site [nucleotide binding]; other site 156889001495 putative cAMP binding site [chemical binding]; other site 156889001496 Leucine rich repeat; Region: LRR_8; pfam13855 156889001497 Leucine rich repeat; Region: LRR_8; pfam13855 156889001498 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 156889001499 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 156889001500 G1 box; other site 156889001501 GTP/Mg2+ binding site [chemical binding]; other site 156889001502 G2 box; other site 156889001503 Switch I region; other site 156889001504 G3 box; other site 156889001505 Switch II region; other site 156889001506 G4 box; other site 156889001507 G5 box; other site 156889001508 Bacterial SH3 domain; Region: SH3_3; cl17532 156889001509 Bacterial SH3 domain; Region: SH3_3; cl17532 156889001510 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 156889001511 GAF domain; Region: GAF_3; pfam13492 156889001512 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889001513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889001514 putative active site [active] 156889001515 heme pocket [chemical binding]; other site 156889001516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889001517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889001518 dimer interface [polypeptide binding]; other site 156889001519 phosphorylation site [posttranslational modification] 156889001520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889001521 ATP binding site [chemical binding]; other site 156889001522 Mg2+ binding site [ion binding]; other site 156889001523 G-X-G motif; other site 156889001524 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889001525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 156889001526 active site 156889001527 phosphorylation site [posttranslational modification] 156889001528 intermolecular recognition site; other site 156889001529 dimerization interface [polypeptide binding]; other site 156889001530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889001531 Response regulator receiver domain; Region: Response_reg; pfam00072 156889001532 active site 156889001533 phosphorylation site [posttranslational modification] 156889001534 intermolecular recognition site; other site 156889001535 dimerization interface [polypeptide binding]; other site 156889001536 HPP family; Region: HPP; pfam04982 156889001537 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 156889001538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889001539 binding surface 156889001540 TPR motif; other site 156889001541 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 156889001542 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 156889001543 ligand binding site [chemical binding]; other site 156889001544 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 156889001545 TolB amino-terminal domain; Region: TolB_N; pfam04052 156889001546 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 156889001547 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 156889001548 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 156889001549 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 156889001550 TolA protein; Region: tolA_full; TIGR02794 156889001551 TonB C terminal; Region: TonB_2; pfam13103 156889001552 TonB C terminal; Region: TonB_2; pfam13103 156889001553 TolA protein; Region: tolA_full; TIGR02794 156889001554 TonB C terminal; Region: TonB_2; pfam13103 156889001555 TolA protein; Region: tolA_full; TIGR02794 156889001556 TonB C terminal; Region: TonB_2; pfam13103 156889001557 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 156889001558 TolR protein; Region: tolR; TIGR02801 156889001559 TolQ protein; Region: tolQ; TIGR02796 156889001560 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 156889001561 active site 156889001562 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 156889001563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889001564 Walker A motif; other site 156889001565 ATP binding site [chemical binding]; other site 156889001566 Walker B motif; other site 156889001567 arginine finger; other site 156889001568 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 156889001569 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889001570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889001571 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889001572 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889001573 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889001574 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889001575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889001576 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 156889001577 RuvA N terminal domain; Region: RuvA_N; pfam01330 156889001578 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 156889001579 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 156889001580 active site 156889001581 putative DNA-binding cleft [nucleotide binding]; other site 156889001582 dimer interface [polypeptide binding]; other site 156889001583 hypothetical protein; Validated; Region: PRK00110 156889001584 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 156889001585 Cysteine-rich domain; Region: CCG; pfam02754 156889001586 Tim44-like domain; Region: Tim44; pfam04280 156889001587 MltA specific insert domain; Region: MltA; smart00925 156889001588 3D domain; Region: 3D; pfam06725 156889001589 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 156889001590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889001591 ATP binding site [chemical binding]; other site 156889001592 putative Mg++ binding site [ion binding]; other site 156889001593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889001594 nucleotide binding region [chemical binding]; other site 156889001595 ATP-binding site [chemical binding]; other site 156889001596 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 156889001597 active site 156889001598 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 156889001599 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 156889001600 dimerization interface [polypeptide binding]; other site 156889001601 ligand binding site [chemical binding]; other site 156889001602 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 156889001603 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 156889001604 TM-ABC transporter signature motif; other site 156889001605 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 156889001606 TM-ABC transporter signature motif; other site 156889001607 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 156889001608 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 156889001609 Walker A/P-loop; other site 156889001610 ATP binding site [chemical binding]; other site 156889001611 Q-loop/lid; other site 156889001612 ABC transporter signature motif; other site 156889001613 Walker B; other site 156889001614 D-loop; other site 156889001615 H-loop/switch region; other site 156889001616 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 156889001617 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 156889001618 Walker A/P-loop; other site 156889001619 ATP binding site [chemical binding]; other site 156889001620 Q-loop/lid; other site 156889001621 ABC transporter signature motif; other site 156889001622 Walker B; other site 156889001623 D-loop; other site 156889001624 H-loop/switch region; other site 156889001625 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 156889001626 tetramer interfaces [polypeptide binding]; other site 156889001627 binuclear metal-binding site [ion binding]; other site 156889001628 Competence-damaged protein; Region: CinA; pfam02464 156889001629 L,D-transpeptidase; Provisional; Region: PRK10190 156889001630 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 156889001631 AAA ATPase domain; Region: AAA_16; pfam13191 156889001632 NB-ARC domain; Region: NB-ARC; pfam00931 156889001633 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889001634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889001635 binding surface 156889001636 TPR motif; other site 156889001637 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889001638 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889001639 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889001640 binding surface 156889001641 TPR motif; other site 156889001642 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889001643 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889001644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889001645 binding surface 156889001646 TPR motif; other site 156889001647 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889001648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889001649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889001650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889001651 binding surface 156889001652 TPR motif; other site 156889001653 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889001654 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 156889001655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889001656 S-adenosylmethionine binding site [chemical binding]; other site 156889001657 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 156889001658 putative active site [active] 156889001659 metal binding site [ion binding]; metal-binding site 156889001660 homodimer binding site [polypeptide binding]; other site 156889001661 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 156889001662 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 156889001663 ATP binding site [chemical binding]; other site 156889001664 active site 156889001665 substrate binding site [chemical binding]; other site 156889001666 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 156889001667 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 156889001668 dimerization interface [polypeptide binding]; other site 156889001669 ATP binding site [chemical binding]; other site 156889001670 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 156889001671 dimerization interface [polypeptide binding]; other site 156889001672 ATP binding site [chemical binding]; other site 156889001673 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 156889001674 putative active site [active] 156889001675 catalytic triad [active] 156889001676 Maf-like protein; Region: Maf; pfam02545 156889001677 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 156889001678 active site 156889001679 dimer interface [polypeptide binding]; other site 156889001680 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 156889001681 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 156889001682 active site residue [active] 156889001683 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 156889001684 active site residue [active] 156889001685 signal recognition particle protein; Provisional; Region: PRK10867 156889001686 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 156889001687 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 156889001688 P loop; other site 156889001689 GTP binding site [chemical binding]; other site 156889001690 Signal peptide binding domain; Region: SRP_SPB; pfam02978 156889001691 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 156889001692 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 156889001693 RimM N-terminal domain; Region: RimM; pfam01782 156889001694 PRC-barrel domain; Region: PRC; pfam05239 156889001695 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 156889001696 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 156889001697 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 156889001698 RNA/DNA hybrid binding site [nucleotide binding]; other site 156889001699 active site 156889001700 GrpE; Region: GrpE; pfam01025 156889001701 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 156889001702 dimer interface [polypeptide binding]; other site 156889001703 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 156889001704 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 156889001705 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 156889001706 nucleotide binding site [chemical binding]; other site 156889001707 NEF interaction site [polypeptide binding]; other site 156889001708 SBD interface [polypeptide binding]; other site 156889001709 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 156889001710 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 156889001711 HSP70 interaction site [polypeptide binding]; other site 156889001712 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 156889001713 substrate binding site [polypeptide binding]; other site 156889001714 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 156889001715 Zn binding sites [ion binding]; other site 156889001716 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 156889001717 dimer interface [polypeptide binding]; other site 156889001718 dihydrodipicolinate reductase; Provisional; Region: PRK00048 156889001719 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 156889001720 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 156889001721 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 156889001722 active site 156889001723 dimer interface [polypeptide binding]; other site 156889001724 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 156889001725 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 156889001726 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 156889001727 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 156889001728 Domain of unknown function DUF21; Region: DUF21; pfam01595 156889001729 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 156889001730 Transporter associated domain; Region: CorC_HlyC; smart01091 156889001731 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 156889001732 Domain of unknown function DUF21; Region: DUF21; pfam01595 156889001733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 156889001734 Transporter associated domain; Region: CorC_HlyC; pfam03471 156889001735 MARCKS family; Region: MARCKS; pfam02063 156889001736 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 156889001737 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 156889001738 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 156889001739 active site 156889001740 substrate binding site [chemical binding]; other site 156889001741 trimer interface [polypeptide binding]; other site 156889001742 CoA binding site [chemical binding]; other site 156889001743 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 156889001744 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 156889001745 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 156889001746 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 156889001747 Ligand binding site [chemical binding]; other site 156889001748 Electron transfer flavoprotein domain; Region: ETF; pfam01012 156889001749 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 156889001750 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 156889001751 catalytic residues [active] 156889001752 hinge region; other site 156889001753 alpha helical domain; other site 156889001754 OsmC-like protein; Region: OsmC; cl00767 156889001755 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 156889001756 DHH family; Region: DHH; pfam01368 156889001757 lipoyl synthase; Provisional; Region: PRK05481 156889001758 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889001759 FeS/SAM binding site; other site 156889001760 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 156889001761 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 156889001762 nudix motif; other site 156889001763 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 156889001764 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 156889001765 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 156889001766 protein binding site [polypeptide binding]; other site 156889001767 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 156889001768 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 156889001769 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 156889001770 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 156889001771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889001772 Walker A motif; other site 156889001773 ATP binding site [chemical binding]; other site 156889001774 Walker B motif; other site 156889001775 arginine finger; other site 156889001776 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 156889001777 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 156889001778 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 156889001779 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 156889001780 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 156889001781 nucleophilic elbow; other site 156889001782 catalytic triad; other site 156889001783 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 156889001784 homodimer interface [polypeptide binding]; other site 156889001785 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 156889001786 Walker A motif; other site 156889001787 ATP binding site [chemical binding]; other site 156889001788 hydroxycobalamin binding site [chemical binding]; other site 156889001789 Walker B motif; other site 156889001790 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 156889001791 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 156889001792 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 156889001793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 156889001794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 156889001795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889001796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889001797 dimer interface [polypeptide binding]; other site 156889001798 phosphorylation site [posttranslational modification] 156889001799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889001800 ATP binding site [chemical binding]; other site 156889001801 Mg2+ binding site [ion binding]; other site 156889001802 G-X-G motif; other site 156889001803 Response regulator receiver domain; Region: Response_reg; pfam00072 156889001804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889001805 active site 156889001806 phosphorylation site [posttranslational modification] 156889001807 intermolecular recognition site; other site 156889001808 dimerization interface [polypeptide binding]; other site 156889001809 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 156889001810 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889001811 dimer interface [polypeptide binding]; other site 156889001812 putative CheW interface [polypeptide binding]; other site 156889001813 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889001814 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 156889001815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889001816 active site 156889001817 phosphorylation site [posttranslational modification] 156889001818 intermolecular recognition site; other site 156889001819 dimerization interface [polypeptide binding]; other site 156889001820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 156889001821 DNA binding site [nucleotide binding] 156889001822 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 156889001823 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 156889001824 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889001825 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889001826 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 156889001827 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 156889001828 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 156889001829 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 156889001830 Walker A/P-loop; other site 156889001831 ATP binding site [chemical binding]; other site 156889001832 Q-loop/lid; other site 156889001833 ABC transporter signature motif; other site 156889001834 Walker B; other site 156889001835 D-loop; other site 156889001836 H-loop/switch region; other site 156889001837 Heme NO binding; Region: HNOB; pfam07700 156889001838 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 156889001839 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 156889001840 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 156889001841 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 156889001842 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 156889001843 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 156889001844 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 156889001845 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 156889001846 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 156889001847 putative ADP-ribose binding site [chemical binding]; other site 156889001848 putative active site [active] 156889001849 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 156889001850 N-acetyl-D-glucosamine binding site [chemical binding]; other site 156889001851 catalytic residue [active] 156889001852 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 156889001853 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 156889001854 NADP binding site [chemical binding]; other site 156889001855 dimer interface [polypeptide binding]; other site 156889001856 Cytochrome c; Region: Cytochrom_C; pfam00034 156889001857 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 156889001858 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 156889001859 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 156889001860 protein binding site [polypeptide binding]; other site 156889001861 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 156889001862 ligand binding site; other site 156889001863 tetramer interface; other site 156889001864 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 156889001865 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 156889001866 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 156889001867 Substrate binding site; other site 156889001868 metal-binding site 156889001869 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 156889001870 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 156889001871 active site 156889001872 homodimer interface [polypeptide binding]; other site 156889001873 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 156889001874 NeuB family; Region: NeuB; pfam03102 156889001875 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 156889001876 NeuB binding interface [polypeptide binding]; other site 156889001877 putative substrate binding site [chemical binding]; other site 156889001878 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 156889001879 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 156889001880 inhibitor-cofactor binding pocket; inhibition site 156889001881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889001882 catalytic residue [active] 156889001883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889001884 binding surface 156889001885 TPR motif; other site 156889001886 TPR repeat; Region: TPR_11; pfam13414 156889001887 TPR repeat; Region: TPR_11; pfam13414 156889001888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889001889 binding surface 156889001890 TPR motif; other site 156889001891 TPR repeat; Region: TPR_11; pfam13414 156889001892 DNA-J related protein; Region: DNAJ_related; pfam12339 156889001893 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 156889001894 HSP70 interaction site [polypeptide binding]; other site 156889001895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889001896 AAA domain; Region: AAA_21; pfam13304 156889001897 Walker A/P-loop; other site 156889001898 ATP binding site [chemical binding]; other site 156889001899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889001900 Q-loop/lid; other site 156889001901 Walker B; other site 156889001902 D-loop; other site 156889001903 H-loop/switch region; other site 156889001904 Serum amyloid A protein; Region: SAA; pfam00277 156889001905 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 156889001906 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 156889001907 active site 156889001908 dimer interface [polypeptide binding]; other site 156889001909 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 156889001910 Ligand Binding Site [chemical binding]; other site 156889001911 Molecular Tunnel; other site 156889001912 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 156889001913 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 156889001914 Walker A/P-loop; other site 156889001915 ATP binding site [chemical binding]; other site 156889001916 Q-loop/lid; other site 156889001917 ABC transporter signature motif; other site 156889001918 Walker B; other site 156889001919 D-loop; other site 156889001920 H-loop/switch region; other site 156889001921 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 156889001922 putative carbohydrate binding site [chemical binding]; other site 156889001923 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 156889001924 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 156889001925 Membrane transport protein; Region: Mem_trans; cl09117 156889001926 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 156889001927 Uncharacterized conserved protein [Function unknown]; Region: COG2835 156889001928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889001929 S-adenosylmethionine binding site [chemical binding]; other site 156889001930 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 156889001931 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889001932 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 156889001933 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 156889001934 probable O-glycosylation ligase, exosortase A-associated; Region: PEP_O_lig_1; TIGR03097 156889001935 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 156889001936 Bacterial sugar transferase; Region: Bac_transf; pfam02397 156889001937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889001938 Chain length determinant protein; Region: Wzz; cl15801 156889001939 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 156889001940 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 156889001941 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 156889001942 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 156889001943 active site 156889001944 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 156889001945 homodimer interface [polypeptide binding]; other site 156889001946 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 156889001947 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 156889001948 putative active site [active] 156889001949 putative catalytic site [active] 156889001950 FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019 156889001951 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 156889001952 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 156889001953 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 156889001954 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 156889001955 putative ADP-binding pocket [chemical binding]; other site 156889001956 PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353 156889001957 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 156889001958 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 156889001959 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 156889001960 active site 156889001961 dimer interface [polypeptide binding]; other site 156889001962 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 156889001963 Ligand Binding Site [chemical binding]; other site 156889001964 Molecular Tunnel; other site 156889001965 acetyl-CoA synthetase; Provisional; Region: PRK00174 156889001966 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 156889001967 active site 156889001968 CoA binding site [chemical binding]; other site 156889001969 acyl-activating enzyme (AAE) consensus motif; other site 156889001970 AMP binding site [chemical binding]; other site 156889001971 acetate binding site [chemical binding]; other site 156889001972 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 156889001973 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 156889001974 Competence protein; Region: Competence; pfam03772 156889001975 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 156889001976 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 156889001977 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 156889001978 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 156889001979 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 156889001980 GDP-Fucose binding site [chemical binding]; other site 156889001981 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 156889001982 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 156889001983 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889001984 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889001985 dimer interface [polypeptide binding]; other site 156889001986 putative CheW interface [polypeptide binding]; other site 156889001987 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889001988 Hemerythrin; Region: Hemerythrin; cd12107 156889001989 Fe binding site [ion binding]; other site 156889001990 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 156889001991 Walker A motif; other site 156889001992 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 156889001993 Thiolase, C-terminal domain; Region: Thiolase_C; pfam02803 156889001994 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 156889001995 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 156889001996 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 156889001997 Substrate binding site; other site 156889001998 Mg++ binding site; other site 156889001999 metal-binding site 156889002000 Mg++ binding site; other site 156889002001 metal-binding site 156889002002 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 156889002003 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 156889002004 Ligand binding site; other site 156889002005 Putative Catalytic site; other site 156889002006 DXD motif; other site 156889002007 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 156889002008 PYR/PP interface [polypeptide binding]; other site 156889002009 dimer interface [polypeptide binding]; other site 156889002010 TPP binding site [chemical binding]; other site 156889002011 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 156889002012 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 156889002013 TPP-binding site [chemical binding]; other site 156889002014 dimer interface [polypeptide binding]; other site 156889002015 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 156889002016 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 156889002017 inhibitor-cofactor binding pocket; inhibition site 156889002018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889002019 catalytic residue [active] 156889002020 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 156889002021 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 156889002022 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 156889002023 extended (e) SDRs; Region: SDR_e; cd08946 156889002024 NAD(P) binding site [chemical binding]; other site 156889002025 active site 156889002026 substrate binding site [chemical binding]; other site 156889002027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 156889002028 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889002029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889002030 substrate binding pocket [chemical binding]; other site 156889002031 membrane-bound complex binding site; other site 156889002032 hinge residues; other site 156889002033 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 156889002034 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 156889002035 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 156889002036 Probable Catalytic site; other site 156889002037 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 156889002038 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 156889002039 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 156889002040 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 156889002041 P loop; other site 156889002042 GTP binding site [chemical binding]; other site 156889002043 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 156889002044 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 156889002045 N-acetyl-D-glucosamine binding site [chemical binding]; other site 156889002046 catalytic residue [active] 156889002047 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 156889002048 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 156889002049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889002050 S-adenosylmethionine binding site [chemical binding]; other site 156889002051 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 156889002052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889002053 active site 156889002054 phosphorylation site [posttranslational modification] 156889002055 intermolecular recognition site; other site 156889002056 dimerization interface [polypeptide binding]; other site 156889002057 CheB methylesterase; Region: CheB_methylest; pfam01339 156889002058 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 156889002059 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889002060 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889002061 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889002062 dimerization interface [polypeptide binding]; other site 156889002063 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889002064 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889002065 dimer interface [polypeptide binding]; other site 156889002066 putative CheW interface [polypeptide binding]; other site 156889002067 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 156889002068 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889002069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889002070 active site 156889002071 phosphorylation site [posttranslational modification] 156889002072 intermolecular recognition site; other site 156889002073 dimerization interface [polypeptide binding]; other site 156889002074 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 156889002075 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889002076 putative binding surface; other site 156889002077 active site 156889002078 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 156889002079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889002080 ATP binding site [chemical binding]; other site 156889002081 Mg2+ binding site [ion binding]; other site 156889002082 G-X-G motif; other site 156889002083 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 156889002084 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889002085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889002086 active site 156889002087 phosphorylation site [posttranslational modification] 156889002088 intermolecular recognition site; other site 156889002089 dimerization interface [polypeptide binding]; other site 156889002090 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889002091 anti sigma factor interaction site; other site 156889002092 regulatory phosphorylation site [posttranslational modification]; other site 156889002093 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 156889002094 active site 156889002095 thiamine phosphate binding site [chemical binding]; other site 156889002096 pyrophosphate binding site [ion binding]; other site 156889002097 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 156889002098 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889002099 FeS/SAM binding site; other site 156889002100 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 156889002101 active site 156889002102 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 156889002103 DEAD/DEAH box helicase; Region: DEAD; pfam00270 156889002104 DEAD_2; Region: DEAD_2; pfam06733 156889002105 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 156889002106 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 156889002107 Glycoprotease family; Region: Peptidase_M22; pfam00814 156889002108 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 156889002109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 156889002110 Coenzyme A binding pocket [chemical binding]; other site 156889002111 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 156889002112 HEAT repeats; Region: HEAT_2; pfam13646 156889002113 FOG: CBS domain [General function prediction only]; Region: COG0517 156889002114 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 156889002115 Guanylate kinase; Region: Guanylate_kin; pfam00625 156889002116 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 156889002117 active site 156889002118 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 156889002119 putative active site [active] 156889002120 putative metal binding residues [ion binding]; other site 156889002121 signature motif; other site 156889002122 putative dimer interface [polypeptide binding]; other site 156889002123 putative phosphate binding site [ion binding]; other site 156889002124 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 156889002125 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 156889002126 active site 156889002127 metal binding site [ion binding]; metal-binding site 156889002128 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 156889002129 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 156889002130 active site 156889002131 catalytic site [active] 156889002132 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 156889002133 PAS domain S-box; Region: sensory_box; TIGR00229 156889002134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889002135 putative active site [active] 156889002136 heme pocket [chemical binding]; other site 156889002137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889002138 PAS fold; Region: PAS_3; pfam08447 156889002139 putative active site [active] 156889002140 heme pocket [chemical binding]; other site 156889002141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889002142 dimer interface [polypeptide binding]; other site 156889002143 phosphorylation site [posttranslational modification] 156889002144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889002145 ATP binding site [chemical binding]; other site 156889002146 Mg2+ binding site [ion binding]; other site 156889002147 G-X-G motif; other site 156889002148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889002149 active site 156889002150 phosphorylation site [posttranslational modification] 156889002151 intermolecular recognition site; other site 156889002152 dimerization interface [polypeptide binding]; other site 156889002153 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889002154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889002155 active site 156889002156 phosphorylation site [posttranslational modification] 156889002157 intermolecular recognition site; other site 156889002158 dimerization interface [polypeptide binding]; other site 156889002159 Protein of unknown function (DUF790); Region: DUF790; pfam05626 156889002160 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 156889002161 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 156889002162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889002163 ATP binding site [chemical binding]; other site 156889002164 putative Mg++ binding site [ion binding]; other site 156889002165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889002166 nucleotide binding region [chemical binding]; other site 156889002167 ATP-binding site [chemical binding]; other site 156889002168 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 156889002169 active site 156889002170 iron coordination sites [ion binding]; other site 156889002171 substrate binding pocket [chemical binding]; other site 156889002172 Transposase; Region: HTH_Tnp_1; pfam01527 156889002173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 156889002174 HTH-like domain; Region: HTH_21; pfam13276 156889002175 Integrase core domain; Region: rve; pfam00665 156889002176 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 156889002177 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 156889002178 putative active site [active] 156889002179 putative NTP binding site [chemical binding]; other site 156889002180 putative nucleic acid binding site [nucleotide binding]; other site 156889002181 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 156889002182 Integrase core domain; Region: rve_3; pfam13683 156889002183 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889002184 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889002185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889002186 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889002187 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889002188 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889002189 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889002190 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 156889002191 active site 156889002192 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 156889002193 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889002194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889002195 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889002196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889002197 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889002198 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889002199 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889002200 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 156889002201 ThiF family; Region: ThiF; pfam00899 156889002202 ATP binding site [chemical binding]; other site 156889002203 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 156889002204 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 156889002205 active site 156889002206 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 156889002207 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 156889002208 ATP-grasp domain; Region: ATP-grasp_4; cl17255 156889002209 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 156889002210 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 156889002211 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 156889002212 carboxyltransferase (CT) interaction site; other site 156889002213 biotinylation site [posttranslational modification]; other site 156889002214 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 156889002215 Dehydroquinase class II; Region: DHquinase_II; pfam01220 156889002216 trimer interface [polypeptide binding]; other site 156889002217 active site 156889002218 dimer interface [polypeptide binding]; other site 156889002219 bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840 156889002220 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 156889002221 thiS-thiF/thiG interaction site; other site 156889002222 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 156889002223 ThiS interaction site; other site 156889002224 putative active site [active] 156889002225 tetramer interface [polypeptide binding]; other site 156889002226 Predicted permeases [General function prediction only]; Region: COG0679 156889002227 XdhC Rossmann domain; Region: XdhC_C; pfam13478 156889002228 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 156889002229 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 156889002230 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889002231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889002232 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889002233 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889002234 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889002235 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889002236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889002237 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 156889002238 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 156889002239 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 156889002240 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 156889002241 GatB domain; Region: GatB_Yqey; smart00845 156889002242 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 156889002243 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 156889002244 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 156889002245 electron transport complex RsxE subunit; Provisional; Region: PRK12405 156889002246 electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947 156889002247 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 156889002248 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 156889002249 SLBB domain; Region: SLBB; pfam10531 156889002250 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 156889002251 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 156889002252 Putative Fe-S cluster; Region: FeS; cl17515 156889002253 4Fe-4S binding domain; Region: Fer4; pfam00037 156889002254 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 156889002255 antiporter inner membrane protein; Provisional; Region: PRK11670 156889002256 Domain of unknown function DUF59; Region: DUF59; pfam01883 156889002257 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 156889002258 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 156889002259 putative active site [active] 156889002260 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 156889002261 PIN domain; Region: PIN_3; pfam13470 156889002262 Helix-turn-helix domain; Region: HTH_17; cl17695 156889002263 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 156889002264 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 156889002265 aspartate aminotransferase; Provisional; Region: PRK05764 156889002266 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 156889002267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889002268 homodimer interface [polypeptide binding]; other site 156889002269 catalytic residue [active] 156889002270 excinuclease ABC subunit B; Provisional; Region: PRK05298 156889002271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889002272 ATP binding site [chemical binding]; other site 156889002273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889002274 nucleotide binding region [chemical binding]; other site 156889002275 ATP-binding site [chemical binding]; other site 156889002276 Ultra-violet resistance protein B; Region: UvrB; pfam12344 156889002277 UvrB/uvrC motif; Region: UVR; pfam02151 156889002278 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 156889002279 CheD chemotactic sensory transduction; Region: CheD; cl00810 156889002280 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 156889002281 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 156889002282 catalytic core [active] 156889002283 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 156889002284 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 156889002285 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 156889002286 active site 156889002287 HIGH motif; other site 156889002288 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 156889002289 KMSK motif region; other site 156889002290 tRNA binding surface [nucleotide binding]; other site 156889002291 DALR anticodon binding domain; Region: DALR_1; smart00836 156889002292 anticodon binding site; other site 156889002293 Sporulation related domain; Region: SPOR; pfam05036 156889002294 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 156889002295 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 156889002296 active site 156889002297 dimer interface [polypeptide binding]; other site 156889002298 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 156889002299 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 156889002300 active site 156889002301 FMN binding site [chemical binding]; other site 156889002302 substrate binding site [chemical binding]; other site 156889002303 3Fe-4S cluster binding site [ion binding]; other site 156889002304 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 156889002305 domain interface; other site 156889002306 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 156889002307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 156889002308 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889002309 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889002310 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889002311 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 156889002312 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 156889002313 inhibitor-cofactor binding pocket; inhibition site 156889002314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889002315 catalytic residue [active] 156889002316 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 156889002317 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 156889002318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889002319 FeS/SAM binding site; other site 156889002320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889002321 TPR motif; other site 156889002322 binding surface 156889002323 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 156889002324 Cell division protein ZapA; Region: ZapA; pfam05164 156889002325 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 156889002326 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 156889002327 phosphodiesterase; Provisional; Region: PRK12704 156889002328 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889002329 Zn2+ binding site [ion binding]; other site 156889002330 Mg2+ binding site [ion binding]; other site 156889002331 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 156889002332 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 156889002333 rRNA binding site [nucleotide binding]; other site 156889002334 predicted 30S ribosome binding site; other site 156889002335 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 156889002336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889002337 ATP binding site [chemical binding]; other site 156889002338 Mg2+ binding site [ion binding]; other site 156889002339 G-X-G motif; other site 156889002340 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 156889002341 anchoring element; other site 156889002342 dimer interface [polypeptide binding]; other site 156889002343 ATP binding site [chemical binding]; other site 156889002344 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 156889002345 active site 156889002346 putative metal-binding site [ion binding]; other site 156889002347 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 156889002348 arginine decarboxylase, biosynthetic; Region: speA; TIGR01273 156889002349 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 156889002350 dimer interface [polypeptide binding]; other site 156889002351 active site 156889002352 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 156889002353 catalytic residues [active] 156889002354 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 156889002355 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 156889002356 NifU-like domain; Region: NifU; pfam01106 156889002357 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 156889002358 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 156889002359 amidase catalytic site [active] 156889002360 Zn binding residues [ion binding]; other site 156889002361 substrate binding site [chemical binding]; other site 156889002362 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 156889002363 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 156889002364 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 156889002365 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 156889002366 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 156889002367 Family description; Region: DsbD_2; pfam13386 156889002368 pyruvate kinase; Provisional; Region: PRK06247 156889002369 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 156889002370 domain interfaces; other site 156889002371 active site 156889002372 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 156889002373 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 156889002374 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889002375 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 156889002376 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 156889002377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889002378 Walker A/P-loop; other site 156889002379 ATP binding site [chemical binding]; other site 156889002380 Q-loop/lid; other site 156889002381 ABC transporter signature motif; other site 156889002382 Walker B; other site 156889002383 D-loop; other site 156889002384 H-loop/switch region; other site 156889002385 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 156889002386 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 156889002387 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 156889002388 Walker A/P-loop; other site 156889002389 ATP binding site [chemical binding]; other site 156889002390 Q-loop/lid; other site 156889002391 ABC transporter signature motif; other site 156889002392 Walker B; other site 156889002393 D-loop; other site 156889002394 H-loop/switch region; other site 156889002395 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 156889002396 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889002397 ATP binding site [chemical binding]; other site 156889002398 putative Mg++ binding site [ion binding]; other site 156889002399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889002400 nucleotide binding region [chemical binding]; other site 156889002401 ATP-binding site [chemical binding]; other site 156889002402 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 156889002403 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 156889002404 Transferrin; Region: Transferrin; cl02460 156889002405 PAS domain; Region: PAS_9; pfam13426 156889002406 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 156889002407 GAF domain; Region: GAF; pfam01590 156889002408 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 156889002409 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 156889002410 active site 156889002411 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 156889002412 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 156889002413 domain interfaces; other site 156889002414 active site 156889002415 CHASE3 domain; Region: CHASE3; cl05000 156889002416 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 156889002417 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 156889002418 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889002419 dimerization interface [polypeptide binding]; other site 156889002420 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889002421 dimer interface [polypeptide binding]; other site 156889002422 putative CheW interface [polypeptide binding]; other site 156889002423 UGMP family protein; Validated; Region: PRK09604 156889002424 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 156889002425 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 156889002426 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 156889002427 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 156889002428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 156889002429 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 156889002430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889002431 active site 156889002432 phosphorylation site [posttranslational modification] 156889002433 intermolecular recognition site; other site 156889002434 dimerization interface [polypeptide binding]; other site 156889002435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889002436 Walker A motif; other site 156889002437 ATP binding site [chemical binding]; other site 156889002438 Walker B motif; other site 156889002439 arginine finger; other site 156889002440 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 156889002441 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 156889002442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889002443 dimerization interface [polypeptide binding]; other site 156889002444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889002445 dimer interface [polypeptide binding]; other site 156889002446 phosphorylation site [posttranslational modification] 156889002447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889002448 ATP binding site [chemical binding]; other site 156889002449 Mg2+ binding site [ion binding]; other site 156889002450 G-X-G motif; other site 156889002451 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 156889002452 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 156889002453 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 156889002454 cell division protein FtsZ; Validated; Region: PRK09330 156889002455 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 156889002456 nucleotide binding site [chemical binding]; other site 156889002457 SulA interaction site; other site 156889002458 cell division protein FtsA; Region: ftsA; TIGR01174 156889002459 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 156889002460 nucleotide binding site [chemical binding]; other site 156889002461 Cell division protein FtsA; Region: FtsA; pfam14450 156889002462 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 156889002463 Cell division protein FtsQ; Region: FtsQ; pfam03799 156889002464 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 156889002465 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 156889002466 ATP-grasp domain; Region: ATP-grasp_4; cl17255 156889002467 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 156889002468 FAD binding domain; Region: FAD_binding_4; pfam01565 156889002469 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 156889002470 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 156889002471 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 156889002472 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 156889002473 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 156889002474 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 156889002475 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 156889002476 active site 156889002477 homodimer interface [polypeptide binding]; other site 156889002478 cell division protein FtsW; Region: ftsW; TIGR02614 156889002479 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 156889002480 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 156889002481 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 156889002482 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 156889002483 Mg++ binding site [ion binding]; other site 156889002484 putative catalytic motif [active] 156889002485 putative substrate binding site [chemical binding]; other site 156889002486 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 156889002487 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 156889002488 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 156889002489 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 156889002490 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 156889002491 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 156889002492 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 156889002493 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 156889002494 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 156889002495 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 156889002496 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 156889002497 Cell division protein FtsL; Region: FtsL; cl11433 156889002498 MraW methylase family; Region: Methyltransf_5; cl17771 156889002499 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 156889002500 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 156889002501 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 156889002502 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 156889002503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 156889002504 DNA-binding site [nucleotide binding]; DNA binding site 156889002505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 156889002506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889002507 homodimer interface [polypeptide binding]; other site 156889002508 catalytic residue [active] 156889002509 malate dehydrogenase; Provisional; Region: PRK13529 156889002510 Malic enzyme, N-terminal domain; Region: malic; pfam00390 156889002511 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 156889002512 NAD(P) binding site [chemical binding]; other site 156889002513 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 156889002514 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 156889002515 NAD binding site [chemical binding]; other site 156889002516 homodimer interface [polypeptide binding]; other site 156889002517 active site 156889002518 substrate binding site [chemical binding]; other site 156889002519 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 156889002520 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 156889002521 active site 156889002522 PAS domain S-box; Region: sensory_box; TIGR00229 156889002523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889002524 putative active site [active] 156889002525 heme pocket [chemical binding]; other site 156889002526 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889002527 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889002528 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889002529 putative active site [active] 156889002530 heme pocket [chemical binding]; other site 156889002531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889002532 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889002533 dimer interface [polypeptide binding]; other site 156889002534 phosphorylation site [posttranslational modification] 156889002535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889002536 ATP binding site [chemical binding]; other site 156889002537 Mg2+ binding site [ion binding]; other site 156889002538 G-X-G motif; other site 156889002539 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889002540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889002541 active site 156889002542 phosphorylation site [posttranslational modification] 156889002543 intermolecular recognition site; other site 156889002544 dimerization interface [polypeptide binding]; other site 156889002545 methionine gamma-lyase; Provisional; Region: PRK07503 156889002546 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 156889002547 homodimer interface [polypeptide binding]; other site 156889002548 substrate-cofactor binding pocket; other site 156889002549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889002550 catalytic residue [active] 156889002551 Domain of unknown function DUF302; Region: DUF302; cl01364 156889002552 LysR family transcriptional regulator; Provisional; Region: PRK14997 156889002553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 156889002554 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 156889002555 dimerization interface [polypeptide binding]; other site 156889002556 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 156889002557 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 156889002558 FMN binding site [chemical binding]; other site 156889002559 active site 156889002560 substrate binding site [chemical binding]; other site 156889002561 catalytic residue [active] 156889002562 Pirin-related protein [General function prediction only]; Region: COG1741 156889002563 Pirin; Region: Pirin; pfam02678 156889002564 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 156889002565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889002566 Response regulator receiver domain; Region: Response_reg; pfam00072 156889002567 active site 156889002568 phosphorylation site [posttranslational modification] 156889002569 intermolecular recognition site; other site 156889002570 dimerization interface [polypeptide binding]; other site 156889002571 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 156889002572 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 156889002573 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 156889002574 Surface antigen; Region: Bac_surface_Ag; pfam01103 156889002575 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 156889002576 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 156889002577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889002578 putative active site [active] 156889002579 heme pocket [chemical binding]; other site 156889002580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889002581 putative active site [active] 156889002582 heme pocket [chemical binding]; other site 156889002583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889002584 dimer interface [polypeptide binding]; other site 156889002585 phosphorylation site [posttranslational modification] 156889002586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889002587 ATP binding site [chemical binding]; other site 156889002588 G-X-G motif; other site 156889002589 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889002590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889002591 active site 156889002592 phosphorylation site [posttranslational modification] 156889002593 intermolecular recognition site; other site 156889002594 dimerization interface [polypeptide binding]; other site 156889002595 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889002596 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889002597 substrate binding pocket [chemical binding]; other site 156889002598 membrane-bound complex binding site; other site 156889002599 hinge residues; other site 156889002600 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 156889002601 putative active site [active] 156889002602 catalytic site [active] 156889002603 DEAD-like helicases superfamily; Region: DEXDc; smart00487 156889002604 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889002605 ATP binding site [chemical binding]; other site 156889002606 putative Mg++ binding site [ion binding]; other site 156889002607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889002608 nucleotide binding region [chemical binding]; other site 156889002609 ATP-binding site [chemical binding]; other site 156889002610 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 156889002611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 156889002612 AAA domain; Region: AAA_33; pfam13671 156889002613 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 156889002614 DNA methylase; Region: N6_N4_Mtase; pfam01555 156889002615 Fic/DOC family; Region: Fic; cl00960 156889002616 Restriction endonuclease [Defense mechanisms]; Region: COG3587 156889002617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889002618 ATP binding site [chemical binding]; other site 156889002619 putative Mg++ binding site [ion binding]; other site 156889002620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889002621 dimerization interface [polypeptide binding]; other site 156889002622 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889002623 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889002624 dimer interface [polypeptide binding]; other site 156889002625 putative CheW interface [polypeptide binding]; other site 156889002626 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 156889002627 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 156889002628 CPxP motif; other site 156889002629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 156889002630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 156889002631 Sensors of blue-light using FAD; Region: BLUF; pfam04940 156889002632 Ion transport protein; Region: Ion_trans; pfam00520 156889002633 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 156889002634 AAA ATPase domain; Region: AAA_16; pfam13191 156889002635 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 156889002636 Uncharacterized conserved protein [Function unknown]; Region: COG3410 156889002637 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 156889002638 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 156889002639 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 156889002640 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 156889002641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 156889002642 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 156889002643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 156889002644 DNA binding residues [nucleotide binding] 156889002645 DNA primase, catalytic core; Region: dnaG; TIGR01391 156889002646 CHC2 zinc finger; Region: zf-CHC2; pfam01807 156889002647 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 156889002648 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 156889002649 active site 156889002650 metal binding site [ion binding]; metal-binding site 156889002651 interdomain interaction site; other site 156889002652 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 156889002653 Yqey-like protein; Region: YqeY; pfam09424 156889002654 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 156889002655 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 156889002656 iron-sulfur cluster [ion binding]; other site 156889002657 [2Fe-2S] cluster binding site [ion binding]; other site 156889002658 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 156889002659 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 156889002660 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 156889002661 SLBB domain; Region: SLBB; pfam10531 156889002662 FecR protein; Region: FecR; pfam04773 156889002663 Transposase domain (DUF772); Region: DUF772; pfam05598 156889002664 malate dehydrogenase; Provisional; Region: PRK05442 156889002665 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 156889002666 NAD(P) binding site [chemical binding]; other site 156889002667 dimer interface [polypeptide binding]; other site 156889002668 malate binding site [chemical binding]; other site 156889002669 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 156889002670 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 156889002671 Ribosomal protein L28 [Translation, ribosomal structure and biogenesis]; Region: RpmB; COG0227 156889002672 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 156889002673 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889002674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889002675 TPR motif; other site 156889002676 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889002677 binding surface 156889002678 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 156889002679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889002680 binding surface 156889002681 TPR motif; other site 156889002682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 156889002683 binding surface 156889002684 TPR motif; other site 156889002685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889002686 binding surface 156889002687 TPR motif; other site 156889002688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889002689 binding surface 156889002690 TPR motif; other site 156889002691 TPR repeat; Region: TPR_11; pfam13414 156889002692 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 156889002693 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 156889002694 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 156889002695 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 156889002696 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 156889002697 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 156889002698 active site 156889002699 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 156889002700 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 156889002701 5S rRNA interface [nucleotide binding]; other site 156889002702 CTC domain interface [polypeptide binding]; other site 156889002703 L16 interface [polypeptide binding]; other site 156889002704 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 156889002705 putative active site [active] 156889002706 catalytic residue [active] 156889002707 GTP-binding protein YchF; Reviewed; Region: PRK09601 156889002708 YchF GTPase; Region: YchF; cd01900 156889002709 G1 box; other site 156889002710 GTP/Mg2+ binding site [chemical binding]; other site 156889002711 Switch I region; other site 156889002712 G2 box; other site 156889002713 Switch II region; other site 156889002714 G3 box; other site 156889002715 G4 box; other site 156889002716 G5 box; other site 156889002717 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 156889002718 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 156889002719 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 156889002720 putative active site [active] 156889002721 putative substrate binding site [chemical binding]; other site 156889002722 ATP binding site [chemical binding]; other site 156889002723 aromatic acid decarboxylase; Validated; Region: PRK05920 156889002724 Flavoprotein; Region: Flavoprotein; pfam02441 156889002725 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 156889002726 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 156889002727 Peptidase family U32; Region: Peptidase_U32; pfam01136 156889002728 putative protease; Provisional; Region: PRK15447 156889002729 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 156889002730 Membrane fusogenic activity; Region: BMFP; pfam04380 156889002731 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 156889002732 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 156889002733 NAD(P) binding site [chemical binding]; other site 156889002734 catalytic residues [active] 156889002735 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 156889002736 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 156889002737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889002738 Walker A motif; other site 156889002739 ATP binding site [chemical binding]; other site 156889002740 Walker B motif; other site 156889002741 arginine finger; other site 156889002742 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 156889002743 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 156889002744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889002745 non-specific DNA binding site [nucleotide binding]; other site 156889002746 salt bridge; other site 156889002747 sequence-specific DNA binding site [nucleotide binding]; other site 156889002748 Cupin domain; Region: Cupin_2; cl17218 156889002749 elongation factor Tu; Reviewed; Region: PRK00049 156889002750 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 156889002751 G1 box; other site 156889002752 GEF interaction site [polypeptide binding]; other site 156889002753 GTP/Mg2+ binding site [chemical binding]; other site 156889002754 Switch I region; other site 156889002755 G2 box; other site 156889002756 G3 box; other site 156889002757 Switch II region; other site 156889002758 G4 box; other site 156889002759 G5 box; other site 156889002760 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 156889002761 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 156889002762 Antibiotic Binding Site [chemical binding]; other site 156889002763 Ribosomal protein L33; Region: Ribosomal_L33; pfam00471 156889002764 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 156889002765 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 156889002766 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 156889002767 putative homodimer interface [polypeptide binding]; other site 156889002768 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 156889002769 heterodimer interface [polypeptide binding]; other site 156889002770 homodimer interface [polypeptide binding]; other site 156889002771 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 156889002772 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 156889002773 23S rRNA interface [nucleotide binding]; other site 156889002774 L7/L12 interface [polypeptide binding]; other site 156889002775 putative thiostrepton binding site; other site 156889002776 L25 interface [polypeptide binding]; other site 156889002777 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 156889002778 mRNA/rRNA interface [nucleotide binding]; other site 156889002779 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 156889002780 23S rRNA interface [nucleotide binding]; other site 156889002781 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 156889002782 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 156889002783 peripheral dimer interface [polypeptide binding]; other site 156889002784 core dimer interface [polypeptide binding]; other site 156889002785 L10 interface [polypeptide binding]; other site 156889002786 L11 interface [polypeptide binding]; other site 156889002787 putative EF-Tu interaction site [polypeptide binding]; other site 156889002788 putative EF-G interaction site [polypeptide binding]; other site 156889002789 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 156889002790 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 156889002791 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 156889002792 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 156889002793 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 156889002794 RPB3 interaction site [polypeptide binding]; other site 156889002795 RPB1 interaction site [polypeptide binding]; other site 156889002796 RPB11 interaction site [polypeptide binding]; other site 156889002797 RPB10 interaction site [polypeptide binding]; other site 156889002798 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 156889002799 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 156889002800 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 156889002801 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 156889002802 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 156889002803 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 156889002804 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 156889002805 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 156889002806 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 156889002807 DNA binding site [nucleotide binding] 156889002808 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 156889002809 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 156889002810 S17 interaction site [polypeptide binding]; other site 156889002811 S8 interaction site; other site 156889002812 16S rRNA interaction site [nucleotide binding]; other site 156889002813 streptomycin interaction site [chemical binding]; other site 156889002814 23S rRNA interaction site [nucleotide binding]; other site 156889002815 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 156889002816 30S ribosomal protein S7; Validated; Region: PRK05302 156889002817 elongation factor G; Reviewed; Region: PRK00007 156889002818 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 156889002819 G1 box; other site 156889002820 putative GEF interaction site [polypeptide binding]; other site 156889002821 GTP/Mg2+ binding site [chemical binding]; other site 156889002822 Switch I region; other site 156889002823 G2 box; other site 156889002824 G3 box; other site 156889002825 Switch II region; other site 156889002826 G4 box; other site 156889002827 G5 box; other site 156889002828 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 156889002829 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 156889002830 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 156889002831 elongation factor Tu; Reviewed; Region: PRK00049 156889002832 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 156889002833 G1 box; other site 156889002834 GEF interaction site [polypeptide binding]; other site 156889002835 GTP/Mg2+ binding site [chemical binding]; other site 156889002836 Switch I region; other site 156889002837 G2 box; other site 156889002838 G3 box; other site 156889002839 Switch II region; other site 156889002840 G4 box; other site 156889002841 G5 box; other site 156889002842 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 156889002843 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 156889002844 Antibiotic Binding Site [chemical binding]; other site 156889002845 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 156889002846 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 156889002847 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 156889002848 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 156889002849 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 156889002850 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 156889002851 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 156889002852 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 156889002853 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 156889002854 putative translocon binding site; other site 156889002855 protein-rRNA interface [nucleotide binding]; other site 156889002856 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 156889002857 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 156889002858 G-X-X-G motif; other site 156889002859 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 156889002860 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 156889002861 23S rRNA interface [nucleotide binding]; other site 156889002862 5S rRNA interface [nucleotide binding]; other site 156889002863 putative antibiotic binding site [chemical binding]; other site 156889002864 L25 interface [polypeptide binding]; other site 156889002865 L27 interface [polypeptide binding]; other site 156889002866 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 156889002867 23S rRNA interface [nucleotide binding]; other site 156889002868 putative translocon interaction site; other site 156889002869 signal recognition particle (SRP54) interaction site; other site 156889002870 L23 interface [polypeptide binding]; other site 156889002871 trigger factor interaction site; other site 156889002872 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 156889002873 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 156889002874 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 156889002875 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 156889002876 RNA binding site [nucleotide binding]; other site 156889002877 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 156889002878 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 156889002879 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 156889002880 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 156889002881 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 156889002882 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 156889002883 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 156889002884 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 156889002885 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 156889002886 5S rRNA interface [nucleotide binding]; other site 156889002887 23S rRNA interface [nucleotide binding]; other site 156889002888 L5 interface [polypeptide binding]; other site 156889002889 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 156889002890 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 156889002891 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 156889002892 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 156889002893 23S rRNA binding site [nucleotide binding]; other site 156889002894 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 156889002895 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 156889002896 SecY translocase; Region: SecY; pfam00344 156889002897 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 156889002898 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 156889002899 30S ribosomal protein S13; Region: bact_S13; TIGR03631 156889002900 30S ribosomal protein S11; Validated; Region: PRK05309 156889002901 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 156889002902 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 156889002903 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 156889002904 RNA binding surface [nucleotide binding]; other site 156889002905 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 156889002906 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 156889002907 alphaNTD - beta interaction site [polypeptide binding]; other site 156889002908 alphaNTD homodimer interface [polypeptide binding]; other site 156889002909 alphaNTD - beta' interaction site [polypeptide binding]; other site 156889002910 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 156889002911 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 156889002912 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889002913 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889002914 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 156889002915 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 156889002916 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 156889002917 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 156889002918 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 156889002919 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 156889002920 putative active site [active] 156889002921 putative dimer interface [polypeptide binding]; other site 156889002922 Hydrogenase formation hypA family; Region: HypD; pfam01924 156889002923 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 156889002924 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 156889002925 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 156889002926 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 156889002927 FAD binding pocket [chemical binding]; other site 156889002928 FAD binding motif [chemical binding]; other site 156889002929 phosphate binding motif [ion binding]; other site 156889002930 beta-alpha-beta structure motif; other site 156889002931 NAD binding pocket [chemical binding]; other site 156889002932 Iron coordination center [ion binding]; other site 156889002933 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 156889002934 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 156889002935 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 156889002936 nickel binding site [ion binding]; other site 156889002937 Peptidase family M48; Region: Peptidase_M48; pfam01435 156889002938 PAS domain; Region: PAS; smart00091 156889002939 PAS domain; Region: PAS_9; pfam13426 156889002940 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889002941 metal binding site [ion binding]; metal-binding site 156889002942 active site 156889002943 I-site; other site 156889002944 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889002945 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 156889002946 catalytic site [active] 156889002947 putative active site [active] 156889002948 putative substrate binding site [chemical binding]; other site 156889002949 FOG: WD40 repeat [General function prediction only]; Region: COG2319 156889002950 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 156889002951 structural tetrad; other site 156889002952 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 156889002953 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 156889002954 acyl-activating enzyme (AAE) consensus motif; other site 156889002955 putative AMP binding site [chemical binding]; other site 156889002956 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 156889002957 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 156889002958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889002959 FeS/SAM binding site; other site 156889002960 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 156889002961 metal binding site 2 [ion binding]; metal-binding site 156889002962 putative DNA binding helix; other site 156889002963 metal binding site 1 [ion binding]; metal-binding site 156889002964 dimer interface [polypeptide binding]; other site 156889002965 structural Zn2+ binding site [ion binding]; other site 156889002966 HAMP domain; Region: HAMP; pfam00672 156889002967 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889002968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889002969 putative active site [active] 156889002970 heme pocket [chemical binding]; other site 156889002971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889002972 dimer interface [polypeptide binding]; other site 156889002973 phosphorylation site [posttranslational modification] 156889002974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889002975 ATP binding site [chemical binding]; other site 156889002976 Mg2+ binding site [ion binding]; other site 156889002977 G-X-G motif; other site 156889002978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889002979 active site 156889002980 phosphorylation site [posttranslational modification] 156889002981 intermolecular recognition site; other site 156889002982 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 156889002983 Dynamin family; Region: Dynamin_N; pfam00350 156889002984 G1 box; other site 156889002985 GTP/Mg2+ binding site [chemical binding]; other site 156889002986 G2 box; other site 156889002987 Switch I region; other site 156889002988 G3 box; other site 156889002989 Switch II region; other site 156889002990 G4 box; other site 156889002991 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 156889002992 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 156889002993 dimer interface [polypeptide binding]; other site 156889002994 active site 156889002995 citrylCoA binding site [chemical binding]; other site 156889002996 NADH binding [chemical binding]; other site 156889002997 cationic pore residues; other site 156889002998 oxalacetate/citrate binding site [chemical binding]; other site 156889002999 coenzyme A binding site [chemical binding]; other site 156889003000 catalytic triad [active] 156889003001 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 156889003002 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 156889003003 PYR/PP interface [polypeptide binding]; other site 156889003004 dimer interface [polypeptide binding]; other site 156889003005 TPP binding site [chemical binding]; other site 156889003006 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 156889003007 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 156889003008 TPP-binding site [chemical binding]; other site 156889003009 dimer interface [polypeptide binding]; other site 156889003010 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 156889003011 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 156889003012 putative valine binding site [chemical binding]; other site 156889003013 dimer interface [polypeptide binding]; other site 156889003014 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 156889003015 ketol-acid reductoisomerase; Provisional; Region: PRK05479 156889003016 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 156889003017 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 156889003018 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 156889003019 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 156889003020 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 156889003021 2-isopropylmalate synthase; Validated; Region: PRK00915 156889003022 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 156889003023 active site 156889003024 catalytic residues [active] 156889003025 metal binding site [ion binding]; metal-binding site 156889003026 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 156889003027 GTP-binding protein LepA; Provisional; Region: PRK05433 156889003028 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 156889003029 G1 box; other site 156889003030 putative GEF interaction site [polypeptide binding]; other site 156889003031 GTP/Mg2+ binding site [chemical binding]; other site 156889003032 Switch I region; other site 156889003033 G2 box; other site 156889003034 G3 box; other site 156889003035 Switch II region; other site 156889003036 G4 box; other site 156889003037 G5 box; other site 156889003038 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 156889003039 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 156889003040 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 156889003041 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 156889003042 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 156889003043 Catalytic site [active] 156889003044 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 156889003045 ribonuclease III; Reviewed; Region: rnc; PRK00102 156889003046 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 156889003047 dimerization interface [polypeptide binding]; other site 156889003048 active site 156889003049 metal binding site [ion binding]; metal-binding site 156889003050 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 156889003051 dsRNA binding site [nucleotide binding]; other site 156889003052 GTPase Era; Reviewed; Region: era; PRK00089 156889003053 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 156889003054 G1 box; other site 156889003055 GTP/Mg2+ binding site [chemical binding]; other site 156889003056 Switch I region; other site 156889003057 G2 box; other site 156889003058 Switch II region; other site 156889003059 G3 box; other site 156889003060 G4 box; other site 156889003061 G5 box; other site 156889003062 KH domain; Region: KH_2; pfam07650 156889003063 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 156889003064 Recombination protein O N terminal; Region: RecO_N; pfam11967 156889003065 Recombination protein O C terminal; Region: RecO_C; pfam02565 156889003066 Uncharacterized conserved protein [Function unknown]; Region: COG2835 156889003067 Domain of unknown function DUF21; Region: DUF21; pfam01595 156889003068 gliding motility-associated protein GldE; Region: GldE; TIGR03520 156889003069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 156889003070 Transporter associated domain; Region: CorC_HlyC; smart01091 156889003071 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 156889003072 Domain of unknown function DUF21; Region: DUF21; pfam01595 156889003073 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 156889003074 Transporter associated domain; Region: CorC_HlyC; smart01091 156889003075 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 156889003076 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 156889003077 Substrate binding site; other site 156889003078 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 156889003079 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889003080 IHF dimer interface [polypeptide binding]; other site 156889003081 IHF - DNA interface [nucleotide binding]; other site 156889003082 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 156889003083 Antirestriction protein (ArdA); Region: ArdA; cl01953 156889003084 SapC; Region: SapC; pfam07277 156889003085 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889003086 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889003087 dimer interface [polypeptide binding]; other site 156889003088 putative CheW interface [polypeptide binding]; other site 156889003089 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889003090 Sel1-like repeats; Region: SEL1; smart00671 156889003091 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 156889003092 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 156889003093 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 156889003094 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 156889003095 Mg++ binding site [ion binding]; other site 156889003096 putative catalytic motif [active] 156889003097 Sporulation related domain; Region: SPOR; cl10051 156889003098 Sporulation related domain; Region: SPOR; pfam05036 156889003099 Sporulation related domain; Region: SPOR; pfam05036 156889003100 Sporulation related domain; Region: SPOR; pfam05036 156889003101 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889003102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889003103 active site 156889003104 phosphorylation site [posttranslational modification] 156889003105 intermolecular recognition site; other site 156889003106 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 156889003107 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 156889003108 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 156889003109 Secretin and TonB N terminus short domain; Region: STN; pfam07660 156889003110 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 156889003111 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 156889003112 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 156889003113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889003114 Walker A motif; other site 156889003115 ATP binding site [chemical binding]; other site 156889003116 Walker B motif; other site 156889003117 arginine finger; other site 156889003118 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 156889003119 Sporulation related domain; Region: SPOR; pfam05036 156889003120 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 156889003121 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 156889003122 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 156889003123 Walker A motif; other site 156889003124 ATP binding site [chemical binding]; other site 156889003125 Walker B motif; other site 156889003126 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 156889003127 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 156889003128 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 156889003129 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 156889003130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 156889003131 active site 156889003132 ATP binding site [chemical binding]; other site 156889003133 substrate binding site [chemical binding]; other site 156889003134 activation loop (A-loop); other site 156889003135 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889003136 Sel1 repeat; Region: Sel1; pfam08238 156889003137 Sel1-like repeats; Region: SEL1; smart00671 156889003138 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889003139 Sel1-like repeats; Region: SEL1; smart00671 156889003140 Sel1 repeat; Region: Sel1; pfam08238 156889003141 Sel1-like repeats; Region: SEL1; smart00671 156889003142 Sel1-like repeats; Region: SEL1; smart00671 156889003143 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 156889003144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889003145 ATP binding site [chemical binding]; other site 156889003146 putative Mg++ binding site [ion binding]; other site 156889003147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889003148 nucleotide binding region [chemical binding]; other site 156889003149 ATP-binding site [chemical binding]; other site 156889003150 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 156889003151 Uncharacterized conserved protein [Function unknown]; Region: COG0398 156889003152 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 156889003153 fructokinase; Reviewed; Region: PRK09557 156889003154 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 156889003155 nucleotide binding site [chemical binding]; other site 156889003156 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 156889003157 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 156889003158 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 156889003159 dimer interface [polypeptide binding]; other site 156889003160 anticodon binding site; other site 156889003161 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 156889003162 homodimer interface [polypeptide binding]; other site 156889003163 motif 1; other site 156889003164 active site 156889003165 motif 2; other site 156889003166 GAD domain; Region: GAD; pfam02938 156889003167 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 156889003168 active site 156889003169 motif 3; other site 156889003170 SEC-C motif; Region: SEC-C; pfam02810 156889003171 TPR repeat; Region: TPR_11; pfam13414 156889003172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889003173 binding surface 156889003174 TPR motif; other site 156889003175 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 156889003176 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 156889003177 active site 156889003178 HIGH motif; other site 156889003179 nucleotide binding site [chemical binding]; other site 156889003180 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 156889003181 active site 156889003182 KMSKS motif; other site 156889003183 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889003184 anti sigma factor interaction site; other site 156889003185 regulatory phosphorylation site [posttranslational modification]; other site 156889003186 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889003187 anti sigma factor interaction site; other site 156889003188 regulatory phosphorylation site [posttranslational modification]; other site 156889003189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889003190 Radical SAM superfamily; Region: Radical_SAM; pfam04055 156889003191 FeS/SAM binding site; other site 156889003192 elongation factor P; Validated; Region: PRK00529 156889003193 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 156889003194 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 156889003195 RNA binding site [nucleotide binding]; other site 156889003196 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 156889003197 RNA binding site [nucleotide binding]; other site 156889003198 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 156889003199 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 156889003200 active site 156889003201 dimer interface [polypeptide binding]; other site 156889003202 motif 2; other site 156889003203 motif 3; other site 156889003204 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 156889003205 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 156889003206 putative catalytic residue [active] 156889003207 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889003208 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889003209 ligand binding site [chemical binding]; other site 156889003210 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 156889003211 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 156889003212 Ligand Binding Site [chemical binding]; other site 156889003213 Cupin domain; Region: Cupin_2; cl17218 156889003214 AAA ATPase domain; Region: AAA_16; pfam13191 156889003215 AAA domain; Region: AAA_22; pfam13401 156889003216 H-type lectin domain; Region: H_lectin; pfam09458 156889003217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 156889003218 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 156889003219 FOG: CBS domain [General function prediction only]; Region: COG0517 156889003220 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 156889003221 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 156889003222 Phosphotransferase enzyme family; Region: APH; pfam01636 156889003223 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 156889003224 active site 156889003225 ATP binding site [chemical binding]; other site 156889003226 substrate binding site [chemical binding]; other site 156889003227 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 156889003228 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 156889003229 Substrate binding site; other site 156889003230 metal-binding site 156889003231 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 156889003232 Methyltransferase domain; Region: Methyltransf_18; pfam12847 156889003233 S-adenosylmethionine binding site [chemical binding]; other site 156889003234 aspartate kinase; Reviewed; Region: PRK06635 156889003235 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 156889003236 putative nucleotide binding site [chemical binding]; other site 156889003237 putative catalytic residues [active] 156889003238 putative Mg ion binding site [ion binding]; other site 156889003239 putative aspartate binding site [chemical binding]; other site 156889003240 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 156889003241 putative allosteric regulatory site; other site 156889003242 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 156889003243 putative allosteric regulatory residue; other site 156889003244 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 156889003245 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 156889003246 active site 156889003247 catalytic residues [active] 156889003248 metal binding site [ion binding]; metal-binding site 156889003249 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 156889003250 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 156889003251 Nitrogen regulatory protein P-II; Region: P-II; smart00938 156889003252 Domain of unknown function DUF302; Region: DUF302; cl01364 156889003253 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 156889003254 probable DNA repair protein; Region: TIGR03623 156889003255 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 156889003256 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 156889003257 Part of AAA domain; Region: AAA_19; pfam13245 156889003258 Family description; Region: UvrD_C_2; pfam13538 156889003259 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 156889003260 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 156889003261 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 156889003262 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 156889003263 metal binding triad [ion binding]; metal-binding site 156889003264 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 156889003265 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 156889003266 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 156889003267 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 156889003268 putative NAD(P) binding site [chemical binding]; other site 156889003269 active site 156889003270 Outer membrane efflux protein; Region: OEP; pfam02321 156889003271 Outer membrane efflux protein; Region: OEP; pfam02321 156889003272 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 156889003273 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889003274 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889003275 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 156889003276 Protein export membrane protein; Region: SecD_SecF; cl14618 156889003277 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 156889003278 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 156889003279 glutamine synthetase; Provisional; Region: glnA; PRK09469 156889003280 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 156889003281 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 156889003282 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 156889003283 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 156889003284 Walker A/P-loop; other site 156889003285 ATP binding site [chemical binding]; other site 156889003286 Q-loop/lid; other site 156889003287 ABC transporter signature motif; other site 156889003288 Walker B; other site 156889003289 D-loop; other site 156889003290 H-loop/switch region; other site 156889003291 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 156889003292 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 156889003293 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 156889003294 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889003295 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 156889003296 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 156889003297 Nitrogen regulatory protein P-II; Region: P-II; smart00938 156889003298 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 156889003299 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 156889003300 putative active site; other site 156889003301 putative triphosphate binding site [ion binding]; other site 156889003302 HDOD domain; Region: HDOD; pfam08668 156889003303 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 156889003304 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 156889003305 ligand binding site [chemical binding]; other site 156889003306 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 156889003307 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 156889003308 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 156889003309 HSP70 interaction site [polypeptide binding]; other site 156889003310 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 156889003311 metal-binding site [ion binding] 156889003312 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 156889003313 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 156889003314 metal-binding site [ion binding] 156889003315 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 156889003316 Soluble P-type ATPase [General function prediction only]; Region: COG4087 156889003317 PAS domain; Region: PAS_8; pfam13188 156889003318 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889003319 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889003320 metal binding site [ion binding]; metal-binding site 156889003321 active site 156889003322 I-site; other site 156889003323 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889003324 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 156889003325 dimer interface [polypeptide binding]; other site 156889003326 FMN binding site [chemical binding]; other site 156889003327 CheD chemotactic sensory transduction; Region: CheD; cl00810 156889003328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 156889003329 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 156889003330 dimer interface [polypeptide binding]; other site 156889003331 phosphorylation site [posttranslational modification] 156889003332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889003333 ATP binding site [chemical binding]; other site 156889003334 Mg2+ binding site [ion binding]; other site 156889003335 G-X-G motif; other site 156889003336 DJ-1 family protein; Region: not_thiJ; TIGR01383 156889003337 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 156889003338 conserved cys residue [active] 156889003339 YciI-like protein; Reviewed; Region: PRK11370 156889003340 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 156889003341 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 156889003342 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 156889003343 Active Sites [active] 156889003344 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 156889003345 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 156889003346 CysD dimerization site [polypeptide binding]; other site 156889003347 G1 box; other site 156889003348 putative GEF interaction site [polypeptide binding]; other site 156889003349 GTP/Mg2+ binding site [chemical binding]; other site 156889003350 Switch I region; other site 156889003351 G2 box; other site 156889003352 G3 box; other site 156889003353 Switch II region; other site 156889003354 G4 box; other site 156889003355 G5 box; other site 156889003356 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 156889003357 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 156889003358 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 156889003359 ligand-binding site [chemical binding]; other site 156889003360 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 156889003361 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 156889003362 putative ligand binding site [chemical binding]; other site 156889003363 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 156889003364 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 156889003365 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 156889003366 TM-ABC transporter signature motif; other site 156889003367 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 156889003368 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 156889003369 TM-ABC transporter signature motif; other site 156889003370 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 156889003371 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 156889003372 Walker A/P-loop; other site 156889003373 ATP binding site [chemical binding]; other site 156889003374 Q-loop/lid; other site 156889003375 ABC transporter signature motif; other site 156889003376 Walker B; other site 156889003377 D-loop; other site 156889003378 H-loop/switch region; other site 156889003379 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 156889003380 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 156889003381 Walker A/P-loop; other site 156889003382 ATP binding site [chemical binding]; other site 156889003383 Q-loop/lid; other site 156889003384 ABC transporter signature motif; other site 156889003385 Walker B; other site 156889003386 D-loop; other site 156889003387 H-loop/switch region; other site 156889003388 UreD urease accessory protein; Region: UreD; pfam01774 156889003389 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 156889003390 alpha-gamma subunit interface [polypeptide binding]; other site 156889003391 beta-gamma subunit interface [polypeptide binding]; other site 156889003392 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 156889003393 gamma-beta subunit interface [polypeptide binding]; other site 156889003394 alpha-beta subunit interface [polypeptide binding]; other site 156889003395 urease subunit alpha; Reviewed; Region: ureC; PRK13207 156889003396 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 156889003397 subunit interactions [polypeptide binding]; other site 156889003398 active site 156889003399 flap region; other site 156889003400 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 156889003401 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 156889003402 dimer interface [polypeptide binding]; other site 156889003403 catalytic residues [active] 156889003404 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 156889003405 UreF; Region: UreF; pfam01730 156889003406 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 156889003407 G1 box; other site 156889003408 GTP/Mg2+ binding site [chemical binding]; other site 156889003409 Switch I region; other site 156889003410 G3 box; other site 156889003411 Switch II region; other site 156889003412 G4 box; other site 156889003413 G5 box; other site 156889003414 peptide chain release factor 2; Validated; Region: prfB; PRK00578 156889003415 This domain is found in peptide chain release factors; Region: PCRF; smart00937 156889003416 RF-1 domain; Region: RF-1; pfam00472 156889003417 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 156889003418 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 156889003419 dimer interface [polypeptide binding]; other site 156889003420 putative anticodon binding site; other site 156889003421 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 156889003422 motif 1; other site 156889003423 active site 156889003424 motif 2; other site 156889003425 motif 3; other site 156889003426 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 156889003427 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 156889003428 FtsX-like permease family; Region: FtsX; pfam02687 156889003429 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 156889003430 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 156889003431 Walker A/P-loop; other site 156889003432 ATP binding site [chemical binding]; other site 156889003433 Q-loop/lid; other site 156889003434 ABC transporter signature motif; other site 156889003435 Walker B; other site 156889003436 D-loop; other site 156889003437 H-loop/switch region; other site 156889003438 Response regulator receiver domain; Region: Response_reg; pfam00072 156889003439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889003440 active site 156889003441 phosphorylation site [posttranslational modification] 156889003442 intermolecular recognition site; other site 156889003443 dimerization interface [polypeptide binding]; other site 156889003444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889003445 PAS domain; Region: PAS_9; pfam13426 156889003446 putative active site [active] 156889003447 heme pocket [chemical binding]; other site 156889003448 PAS domain; Region: PAS; smart00091 156889003449 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889003450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889003451 dimer interface [polypeptide binding]; other site 156889003452 phosphorylation site [posttranslational modification] 156889003453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889003454 ATP binding site [chemical binding]; other site 156889003455 Mg2+ binding site [ion binding]; other site 156889003456 G-X-G motif; other site 156889003457 Response regulator receiver domain; Region: Response_reg; pfam00072 156889003458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 156889003459 active site 156889003460 phosphorylation site [posttranslational modification] 156889003461 intermolecular recognition site; other site 156889003462 dimerization interface [polypeptide binding]; other site 156889003463 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 156889003464 Peptidase family M50; Region: Peptidase_M50; pfam02163 156889003465 active site 156889003466 putative substrate binding region [chemical binding]; other site 156889003467 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 156889003468 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 156889003469 active site 156889003470 HIGH motif; other site 156889003471 dimer interface [polypeptide binding]; other site 156889003472 KMSKS motif; other site 156889003473 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 156889003474 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 156889003475 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 156889003476 RNA binding surface [nucleotide binding]; other site 156889003477 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 156889003478 probable active site [active] 156889003479 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 156889003480 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 156889003481 minor groove reading motif; other site 156889003482 helix-hairpin-helix signature motif; other site 156889003483 substrate binding pocket [chemical binding]; other site 156889003484 active site 156889003485 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 156889003486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889003487 ATP binding site [chemical binding]; other site 156889003488 Mg2+ binding site [ion binding]; other site 156889003489 G-X-G motif; other site 156889003490 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 156889003491 ATP binding site [chemical binding]; other site 156889003492 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 156889003493 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 156889003494 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 156889003495 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 156889003496 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 156889003497 Na binding site [ion binding]; other site 156889003498 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 156889003499 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889003500 ligand binding site [chemical binding]; other site 156889003501 flexible hinge region; other site 156889003502 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 156889003503 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 156889003504 metal binding triad; other site 156889003505 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 156889003506 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 156889003507 active site 156889003508 catalytic site [active] 156889003509 substrate binding site [chemical binding]; other site 156889003510 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 156889003511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889003512 dimerization interface [polypeptide binding]; other site 156889003513 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 156889003514 cyclase homology domain; Region: CHD; cd07302 156889003515 nucleotidyl binding site; other site 156889003516 metal binding site [ion binding]; metal-binding site 156889003517 dimer interface [polypeptide binding]; other site 156889003518 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 156889003519 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 156889003520 RNA binding surface [nucleotide binding]; other site 156889003521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889003522 S-adenosylmethionine binding site [chemical binding]; other site 156889003523 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 156889003524 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 156889003525 TPP-binding site; other site 156889003526 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 156889003527 PYR/PP interface [polypeptide binding]; other site 156889003528 dimer interface [polypeptide binding]; other site 156889003529 TPP binding site [chemical binding]; other site 156889003530 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 156889003531 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 156889003532 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 156889003533 substrate binding pocket [chemical binding]; other site 156889003534 chain length determination region; other site 156889003535 substrate-Mg2+ binding site; other site 156889003536 catalytic residues [active] 156889003537 aspartate-rich region 1; other site 156889003538 active site lid residues [active] 156889003539 aspartate-rich region 2; other site 156889003540 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 156889003541 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 156889003542 Peptidase family M23; Region: Peptidase_M23; pfam01551 156889003543 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 156889003544 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 156889003545 generic binding surface II; other site 156889003546 generic binding surface I; other site 156889003547 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 156889003548 dinuclear metal binding motif [ion binding]; other site 156889003549 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 156889003550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 156889003551 NAD(P) binding site [chemical binding]; other site 156889003552 active site 156889003553 Methyltransferase domain; Region: Methyltransf_31; pfam13847 156889003554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889003555 S-adenosylmethionine binding site [chemical binding]; other site 156889003556 Radical SAM superfamily; Region: Radical_SAM; pfam04055 156889003557 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889003558 FeS/SAM binding site; other site 156889003559 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 156889003560 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 156889003561 PYR/PP interface [polypeptide binding]; other site 156889003562 dimer interface [polypeptide binding]; other site 156889003563 TPP binding site [chemical binding]; other site 156889003564 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 156889003565 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 156889003566 TPP-binding site [chemical binding]; other site 156889003567 dimer interface [polypeptide binding]; other site 156889003568 Phosphotransferase enzyme family; Region: APH; pfam01636 156889003569 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 156889003570 active site 156889003571 ATP binding site [chemical binding]; other site 156889003572 N-terminal domain of RfaE; Region: RfaE_N; cd02172 156889003573 putative active site [active] 156889003574 (T/H)XGH motif; other site 156889003575 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 156889003576 putative ribose interaction site [chemical binding]; other site 156889003577 putative ADP binding site [chemical binding]; other site 156889003578 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 156889003579 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 156889003580 NAD binding site [chemical binding]; other site 156889003581 substrate binding site [chemical binding]; other site 156889003582 homodimer interface [polypeptide binding]; other site 156889003583 active site 156889003584 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889003585 Radical SAM superfamily; Region: Radical_SAM; pfam04055 156889003586 FeS/SAM binding site; other site 156889003587 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 156889003588 adenylosuccinate lyase; Provisional; Region: PRK09285 156889003589 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 156889003590 tetramer interface [polypeptide binding]; other site 156889003591 active site 156889003592 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 156889003593 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 156889003594 Cu(I) binding site [ion binding]; other site 156889003595 Protein of unknown function (DUF461); Region: DUF461; pfam04314 156889003596 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 156889003597 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 156889003598 DNA gyrase subunit A; Validated; Region: PRK05560 156889003599 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 156889003600 CAP-like domain; other site 156889003601 active site 156889003602 primary dimer interface [polypeptide binding]; other site 156889003603 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 156889003604 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 156889003605 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 156889003606 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 156889003607 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 156889003608 seryl-tRNA synthetase; Provisional; Region: PRK05431 156889003609 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 156889003610 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 156889003611 dimer interface [polypeptide binding]; other site 156889003612 active site 156889003613 motif 1; other site 156889003614 motif 2; other site 156889003615 motif 3; other site 156889003616 Protein of unknown function DUF86; Region: DUF86; pfam01934 156889003617 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 156889003618 active site 156889003619 NTP binding site [chemical binding]; other site 156889003620 metal binding triad [ion binding]; metal-binding site 156889003621 antibiotic binding site [chemical binding]; other site 156889003622 glutathionine S-transferase; Provisional; Region: PRK10542 156889003623 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 156889003624 C-terminal domain interface [polypeptide binding]; other site 156889003625 GSH binding site (G-site) [chemical binding]; other site 156889003626 dimer interface [polypeptide binding]; other site 156889003627 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 156889003628 dimer interface [polypeptide binding]; other site 156889003629 substrate binding pocket (H-site) [chemical binding]; other site 156889003630 N-terminal domain interface [polypeptide binding]; other site 156889003631 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 156889003632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889003633 Walker A motif; other site 156889003634 ATP binding site [chemical binding]; other site 156889003635 Walker B motif; other site 156889003636 arginine finger; other site 156889003637 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 156889003638 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 156889003639 Sulfate transporter family; Region: Sulfate_transp; pfam00916 156889003640 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 156889003641 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 156889003642 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 156889003643 NAD(P) binding pocket [chemical binding]; other site 156889003644 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 156889003645 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 156889003646 dimer interface [polypeptide binding]; other site 156889003647 active site 156889003648 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 156889003649 catalytic residues [active] 156889003650 substrate binding site [chemical binding]; other site 156889003651 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 156889003652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889003653 ATP binding site [chemical binding]; other site 156889003654 putative Mg++ binding site [ion binding]; other site 156889003655 nucleotide binding region [chemical binding]; other site 156889003656 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 156889003657 Helicase associated domain (HA2); Region: HA2; pfam04408 156889003658 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 156889003659 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 156889003660 metal binding site [ion binding]; metal-binding site 156889003661 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 156889003662 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 156889003663 diiron binding motif [ion binding]; other site 156889003664 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 156889003665 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 156889003666 putative ATP binding site [chemical binding]; other site 156889003667 putative substrate interface [chemical binding]; other site 156889003668 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 156889003669 active site 156889003670 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889003671 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889003672 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 156889003673 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 156889003674 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003675 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003676 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003677 Ca2+ binding site [ion binding]; other site 156889003678 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003679 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003680 Ca2+ binding site [ion binding]; other site 156889003681 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003682 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003683 Ca2+ binding site [ion binding]; other site 156889003684 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003685 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003686 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003687 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003688 Ca2+ binding site [ion binding]; other site 156889003689 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003690 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003691 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003692 Ca2+ binding site [ion binding]; other site 156889003693 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003694 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003695 Ca2+ binding site [ion binding]; other site 156889003696 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003697 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003698 Ca2+ binding site [ion binding]; other site 156889003699 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003700 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003701 Ca2+ binding site [ion binding]; other site 156889003702 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003703 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003704 Ca2+ binding site [ion binding]; other site 156889003705 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003706 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003707 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003708 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003709 Ca2+ binding site [ion binding]; other site 156889003710 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003711 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003712 Ca2+ binding site [ion binding]; other site 156889003713 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003714 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003715 Ca2+ binding site [ion binding]; other site 156889003716 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003717 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003718 Ca2+ binding site [ion binding]; other site 156889003719 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003720 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003721 Ca2+ binding site [ion binding]; other site 156889003722 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003723 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003724 Ca2+ binding site [ion binding]; other site 156889003725 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003726 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003727 Ca2+ binding site [ion binding]; other site 156889003728 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003729 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003730 Ca2+ binding site [ion binding]; other site 156889003731 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003732 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003733 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003734 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003735 Ca2+ binding site [ion binding]; other site 156889003736 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003737 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003738 Ca2+ binding site [ion binding]; other site 156889003739 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003740 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003741 Ca2+ binding site [ion binding]; other site 156889003742 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003743 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003744 Ca2+ binding site [ion binding]; other site 156889003745 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003746 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003747 Ca2+ binding site [ion binding]; other site 156889003748 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003749 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003750 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003751 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003752 Ca2+ binding site [ion binding]; other site 156889003753 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003754 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003755 Ca2+ binding site [ion binding]; other site 156889003756 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003757 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003758 Ca2+ binding site [ion binding]; other site 156889003759 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003760 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003761 Ca2+ binding site [ion binding]; other site 156889003762 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003763 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003764 Ca2+ binding site [ion binding]; other site 156889003765 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003766 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003767 Ca2+ binding site [ion binding]; other site 156889003768 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003769 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003770 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003771 Ca2+ binding site [ion binding]; other site 156889003772 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003773 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003774 Ca2+ binding site [ion binding]; other site 156889003775 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003776 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003777 Ca2+ binding site [ion binding]; other site 156889003778 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003779 Ca2+ binding site [ion binding]; other site 156889003780 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003781 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003782 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003783 Ca2+ binding site [ion binding]; other site 156889003784 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003785 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003786 Ca2+ binding site [ion binding]; other site 156889003787 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003788 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003789 Ca2+ binding site [ion binding]; other site 156889003790 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003791 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003792 Ca2+ binding site [ion binding]; other site 156889003793 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003794 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003795 Ca2+ binding site [ion binding]; other site 156889003796 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003797 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 156889003798 Ca2+ binding site [ion binding]; other site 156889003799 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003800 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 156889003801 Ca2+ binding site [ion binding]; other site 156889003802 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003803 Cadherin repeat-like domain; Region: CA_like; cl15786 156889003804 Ca2+ binding site [ion binding]; other site 156889003805 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 156889003806 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889003807 Ca2+ binding site [ion binding]; other site 156889003808 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 156889003809 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 156889003810 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 156889003811 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 156889003812 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 156889003813 intermolecular salt bridges; other site 156889003814 calcium mediated ligand binding site; other site 156889003815 Uncharacterized conserved protein [Function unknown]; Region: COG5276 156889003816 LVIVD repeat; Region: LVIVD; pfam08309 156889003817 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 156889003818 Family description; Region: VCBS; pfam13517 156889003819 Family description; Region: VCBS; pfam13517 156889003820 Family description; Region: VCBS; pfam13517 156889003821 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 156889003822 Family description; Region: VCBS; pfam13517 156889003823 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 156889003824 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 156889003825 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 156889003826 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 156889003827 Predicted ATPase [General function prediction only]; Region: COG1485 156889003828 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 156889003829 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 156889003830 CoA binding domain; Region: CoA_binding_2; pfam13380 156889003831 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 156889003832 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 156889003833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889003834 PAS domain; Region: PAS_9; pfam13426 156889003835 putative active site [active] 156889003836 heme pocket [chemical binding]; other site 156889003837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889003838 Response regulator receiver domain; Region: Response_reg; pfam00072 156889003839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889003840 active site 156889003841 phosphorylation site [posttranslational modification] 156889003842 intermolecular recognition site; other site 156889003843 dimerization interface [polypeptide binding]; other site 156889003844 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 156889003845 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889003846 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889003847 ligand binding site [chemical binding]; other site 156889003848 Major Facilitator Superfamily; Region: MFS_1; pfam07690 156889003849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 156889003850 putative substrate translocation pore; other site 156889003851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 156889003852 dimerization interface [polypeptide binding]; other site 156889003853 putative DNA binding site [nucleotide binding]; other site 156889003854 putative Zn2+ binding site [ion binding]; other site 156889003855 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 156889003856 active site residue [active] 156889003857 DsrE/DsrF-like family; Region: DrsE; cl00672 156889003858 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 156889003859 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 156889003860 Uncharacterized conserved protein [Function unknown]; Region: COG0398 156889003861 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 156889003862 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 156889003863 active site residue [active] 156889003864 Cytochrome C' Region: Cytochrom_C_2; pfam01322 156889003865 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 156889003866 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 156889003867 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 156889003868 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889003869 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889003870 ligand binding site [chemical binding]; other site 156889003871 flexible hinge region; other site 156889003872 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 156889003873 Sulfate transporter family; Region: Sulfate_transp; pfam00916 156889003874 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 156889003875 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889003876 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889003877 ligand binding site [chemical binding]; other site 156889003878 flexible hinge region; other site 156889003879 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 156889003880 CHASE2 domain; Region: CHASE2; pfam05226 156889003881 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 156889003882 cyclase homology domain; Region: CHD; cd07302 156889003883 nucleotidyl binding site; other site 156889003884 metal binding site [ion binding]; metal-binding site 156889003885 dimer interface [polypeptide binding]; other site 156889003886 FecR protein; Region: FecR; pfam04773 156889003887 Protein of unknown function (DUF560); Region: DUF560; pfam04575 156889003888 YHYH protein; Region: YHYH; pfam14240 156889003889 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889003890 IHF dimer interface [polypeptide binding]; other site 156889003891 IHF - DNA interface [nucleotide binding]; other site 156889003892 B12 binding domain; Region: B12-binding; pfam02310 156889003893 B12 binding site [chemical binding]; other site 156889003894 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 156889003895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889003896 FeS/SAM binding site; other site 156889003897 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 156889003898 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 156889003899 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 156889003900 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 156889003901 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 156889003902 glutamine binding [chemical binding]; other site 156889003903 catalytic triad [active] 156889003904 anthranilate synthase component I; Provisional; Region: PRK13565 156889003905 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 156889003906 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 156889003907 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 156889003908 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 156889003909 Resolvase, N terminal domain; Region: Resolvase; smart00857 156889003910 Recombinase; Region: Recombinase; pfam07508 156889003911 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 156889003912 putative transposase OrfB; Reviewed; Region: PHA02517 156889003913 HTH-like domain; Region: HTH_21; pfam13276 156889003914 Integrase core domain; Region: rve; pfam00665 156889003915 Integrase core domain; Region: rve_3; pfam13683 156889003916 Transposase; Region: HTH_Tnp_1; pfam01527 156889003917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 156889003918 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 156889003919 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 156889003920 putative active site [active] 156889003921 putative NTP binding site [chemical binding]; other site 156889003922 putative nucleic acid binding site [nucleotide binding]; other site 156889003923 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 156889003924 Integrase core domain; Region: rve_3; pfam13683 156889003925 Winged helix-turn helix; Region: HTH_29; pfam13551 156889003926 Uncharacterized conserved protein [Function unknown]; Region: COG1262 156889003927 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 156889003928 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889003929 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889003930 Acyltransferase family; Region: Acyl_transf_3; pfam01757 156889003931 Methyltransferase domain; Region: Methyltransf_31; pfam13847 156889003932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889003933 S-adenosylmethionine binding site [chemical binding]; other site 156889003934 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 156889003935 classical (c) SDRs; Region: SDR_c; cd05233 156889003936 NAD(P) binding site [chemical binding]; other site 156889003937 active site 156889003938 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 156889003939 FAD binding domain; Region: FAD_binding_4; pfam01565 156889003940 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 156889003941 Ligand binding site; other site 156889003942 Putative Catalytic site; other site 156889003943 DXD motif; other site 156889003944 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 156889003945 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 156889003946 DNA photolyase; Region: DNA_photolyase; pfam00875 156889003947 Methyltransferase domain; Region: Methyltransf_31; pfam13847 156889003948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889003949 S-adenosylmethionine binding site [chemical binding]; other site 156889003950 Cache domain; Region: Cache_2; cl07034 156889003951 HAMP domain; Region: HAMP; pfam00672 156889003952 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889003953 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889003954 metal binding site [ion binding]; metal-binding site 156889003955 active site 156889003956 I-site; other site 156889003957 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 156889003958 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889003959 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889003960 Outer membrane efflux protein; Region: OEP; pfam02321 156889003961 Outer membrane efflux protein; Region: OEP; pfam02321 156889003962 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 156889003963 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889003964 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 156889003965 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 156889003966 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 156889003967 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 156889003968 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889003969 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u8; cd10932 156889003970 NodB motif; other site 156889003971 putative active site [active] 156889003972 putative catalytic site [active] 156889003973 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 156889003974 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889003975 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 156889003976 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 156889003977 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 156889003978 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 156889003979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 156889003980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889003981 homodimer interface [polypeptide binding]; other site 156889003982 catalytic residue [active] 156889003983 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 156889003984 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 156889003985 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 156889003986 acyl-activating enzyme (AAE) consensus motif; other site 156889003987 AMP binding site [chemical binding]; other site 156889003988 active site 156889003989 acyl-activating enzyme (AAE) consensus motif; other site 156889003990 CoA binding site [chemical binding]; other site 156889003991 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 156889003992 putative acyltransferase; Provisional; Region: PRK05790 156889003993 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 156889003994 dimer interface [polypeptide binding]; other site 156889003995 active site 156889003996 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 156889003997 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 156889003998 NAD(P) binding site [chemical binding]; other site 156889003999 homotetramer interface [polypeptide binding]; other site 156889004000 homodimer interface [polypeptide binding]; other site 156889004001 active site 156889004002 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 156889004003 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 156889004004 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 156889004005 Phasin protein; Region: Phasin_2; pfam09361 156889004006 poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit; Region: PHA_synth_III_E; TIGR01834 156889004007 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 156889004008 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 156889004009 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 156889004010 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 156889004011 catalytic residue [active] 156889004012 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u9; cd10933 156889004013 putative active site [active] 156889004014 putative catalytic site [active] 156889004015 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 156889004016 ATP-grasp domain; Region: ATP-grasp_4; cl17255 156889004017 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 156889004018 active site 156889004019 Hemerythrin; Region: Hemerythrin; cd12107 156889004020 Fe binding site [ion binding]; other site 156889004021 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 156889004022 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 156889004023 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 156889004024 Domain of unknown function (DUF364); Region: DUF364; pfam04016 156889004025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889004026 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 156889004027 Walker A/P-loop; other site 156889004028 ATP binding site [chemical binding]; other site 156889004029 Q-loop/lid; other site 156889004030 ABC transporter signature motif; other site 156889004031 Walker B; other site 156889004032 D-loop; other site 156889004033 H-loop/switch region; other site 156889004034 TOBE domain; Region: TOBE; cl01440 156889004035 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 156889004036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 156889004037 dimer interface [polypeptide binding]; other site 156889004038 conserved gate region; other site 156889004039 putative PBP binding loops; other site 156889004040 ABC-ATPase subunit interface; other site 156889004041 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 156889004042 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 156889004043 catalytic loop [active] 156889004044 iron binding site [ion binding]; other site 156889004045 NifZ domain; Region: NifZ; pfam04319 156889004046 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 156889004047 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 156889004048 active site 156889004049 catalytic residues [active] 156889004050 metal binding site [ion binding]; metal-binding site 156889004051 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 156889004052 Protein of unknown function, DUF269; Region: DUF269; pfam03270 156889004053 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 156889004054 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 156889004055 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 156889004056 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 156889004057 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 156889004058 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 156889004059 NifT/FixU protein; Region: NifT; pfam06988 156889004060 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 156889004061 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 156889004062 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 156889004063 MoFe protein beta/alpha subunit interactions; other site 156889004064 Beta subunit P cluster binding residues; other site 156889004065 MoFe protein beta subunit/Fe protein contacts; other site 156889004066 MoFe protein dimer/ dimer interactions; other site 156889004067 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 156889004068 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 156889004069 MoFe protein alpha/beta subunit interactions; other site 156889004070 Alpha subunit P cluster binding residues; other site 156889004071 FeMoco binding residues [chemical binding]; other site 156889004072 MoFe protein alpha subunit/Fe protein contacts; other site 156889004073 MoFe protein dimer/ dimer interactions; other site 156889004074 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 156889004075 nitrogenase iron protein; Region: nifH; TIGR01287 156889004076 Nucleotide-binding sites [chemical binding]; other site 156889004077 Walker A motif; other site 156889004078 Switch I region of nucleotide binding site; other site 156889004079 Fe4S4 binding sites [ion binding]; other site 156889004080 Switch II region of nucleotide binding site; other site 156889004081 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 156889004082 Nif-specific regulatory protein; Region: nifA; TIGR01817 156889004083 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 156889004084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889004085 Walker A motif; other site 156889004086 ATP binding site [chemical binding]; other site 156889004087 Walker B motif; other site 156889004088 arginine finger; other site 156889004089 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 156889004090 HAMP domain; Region: HAMP; pfam00672 156889004091 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 156889004092 cyclase homology domain; Region: CHD; cd07302 156889004093 nucleotidyl binding site; other site 156889004094 metal binding site [ion binding]; metal-binding site 156889004095 dimer interface [polypeptide binding]; other site 156889004096 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 156889004097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889004098 FeS/SAM binding site; other site 156889004099 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 156889004100 4Fe-4S binding domain; Region: Fer4; cl02805 156889004101 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 156889004102 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 156889004103 ArsC family; Region: ArsC; pfam03960 156889004104 putative catalytic residues [active] 156889004105 NifQ; Region: NifQ; pfam04891 156889004106 ADP-ribosyl-[dinitrogen reductase] hydrolase; Region: dinitro_DRAG; TIGR02662 156889004107 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 156889004108 Isochorismatase family; Region: Isochorismatase; pfam00857 156889004109 catalytic triad [active] 156889004110 metal binding site [ion binding]; metal-binding site 156889004111 conserved cis-peptide bond; other site 156889004112 putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513 156889004113 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 156889004114 active site 156889004115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889004116 HAMP domain; Region: HAMP; pfam00672 156889004117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889004118 dimer interface [polypeptide binding]; other site 156889004119 phosphorylation site [posttranslational modification] 156889004120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889004121 ATP binding site [chemical binding]; other site 156889004122 Mg2+ binding site [ion binding]; other site 156889004123 G-X-G motif; other site 156889004124 Response regulator receiver domain; Region: Response_reg; pfam00072 156889004125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004126 active site 156889004127 phosphorylation site [posttranslational modification] 156889004128 intermolecular recognition site; other site 156889004129 dimerization interface [polypeptide binding]; other site 156889004130 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889004131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004132 active site 156889004133 phosphorylation site [posttranslational modification] 156889004134 intermolecular recognition site; other site 156889004135 dimerization interface [polypeptide binding]; other site 156889004136 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 156889004137 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 156889004138 Response regulator receiver domain; Region: Response_reg; pfam00072 156889004139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004140 active site 156889004141 phosphorylation site [posttranslational modification] 156889004142 intermolecular recognition site; other site 156889004143 dimerization interface [polypeptide binding]; other site 156889004144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889004145 PAS fold; Region: PAS_3; pfam08447 156889004146 putative active site [active] 156889004147 heme pocket [chemical binding]; other site 156889004148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889004149 dimer interface [polypeptide binding]; other site 156889004150 phosphorylation site [posttranslational modification] 156889004151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889004152 ATP binding site [chemical binding]; other site 156889004153 Mg2+ binding site [ion binding]; other site 156889004154 G-X-G motif; other site 156889004155 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889004156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004157 active site 156889004158 phosphorylation site [posttranslational modification] 156889004159 intermolecular recognition site; other site 156889004160 dimerization interface [polypeptide binding]; other site 156889004161 putative acetyltransferase; Provisional; Region: PRK03624 156889004162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 156889004163 Coenzyme A binding pocket [chemical binding]; other site 156889004164 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 156889004165 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 156889004166 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 156889004167 histidinol dehydrogenase; Region: hisD; TIGR00069 156889004168 NAD binding site [chemical binding]; other site 156889004169 dimerization interface [polypeptide binding]; other site 156889004170 product binding site; other site 156889004171 substrate binding site [chemical binding]; other site 156889004172 zinc binding site [ion binding]; other site 156889004173 catalytic residues [active] 156889004174 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 156889004175 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 156889004176 hinge; other site 156889004177 active site 156889004178 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 156889004179 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 156889004180 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 156889004181 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 156889004182 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 156889004183 TrkA-N domain; Region: TrkA_N; pfam02254 156889004184 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889004185 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 156889004186 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 156889004187 catalytic residues [active] 156889004188 catalytic nucleophile [active] 156889004189 Presynaptic Site I dimer interface [polypeptide binding]; other site 156889004190 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 156889004191 Synaptic Flat tetramer interface [polypeptide binding]; other site 156889004192 Synaptic Site I dimer interface [polypeptide binding]; other site 156889004193 DNA binding site [nucleotide binding] 156889004194 Recombinase; Region: Recombinase; pfam07508 156889004195 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 156889004196 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 156889004197 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 156889004198 AAA domain; Region: AAA_24; pfam13479 156889004199 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 156889004200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889004201 ATP binding site [chemical binding]; other site 156889004202 putative Mg++ binding site [ion binding]; other site 156889004203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889004204 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 156889004205 nucleotide binding region [chemical binding]; other site 156889004206 ATP-binding site [chemical binding]; other site 156889004207 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 156889004208 ORF6N domain; Region: ORF6N; pfam10543 156889004209 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 156889004210 active site 156889004211 metal binding site [ion binding]; metal-binding site 156889004212 interdomain interaction site; other site 156889004213 AAA domain; Region: AAA_25; pfam13481 156889004214 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 156889004215 Walker A motif; other site 156889004216 ATP binding site [chemical binding]; other site 156889004217 Walker B motif; other site 156889004218 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 156889004219 active site 156889004220 Heat induced stress protein YflT; Region: YflT; pfam11181 156889004221 Peptidase M15; Region: Peptidase_M15_3; cl01194 156889004222 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889004223 IHF dimer interface [polypeptide binding]; other site 156889004224 IHF - DNA interface [nucleotide binding]; other site 156889004225 ParB-like nuclease domain; Region: ParBc; pfam02195 156889004226 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 156889004227 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 156889004228 DNA methylase; Region: N6_N4_Mtase; cl17433 156889004229 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 156889004230 DNA-binding site [nucleotide binding]; DNA binding site 156889004231 RNA-binding motif; other site 156889004232 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889004233 IHF - DNA interface [nucleotide binding]; other site 156889004234 IHF dimer interface [polypeptide binding]; other site 156889004235 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 156889004236 CcdB protein; Region: CcdB; cl03380 156889004237 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 156889004238 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 156889004239 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 156889004240 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 156889004241 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 156889004242 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 156889004243 tandem repeat interface [polypeptide binding]; other site 156889004244 oligomer interface [polypeptide binding]; other site 156889004245 active site residues [active] 156889004246 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889004247 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889004248 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 156889004249 cell surface protein SprA; Region: surface_SprA; TIGR04189 156889004250 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 156889004251 active site 156889004252 substrate binding site [chemical binding]; other site 156889004253 catalytic site [active] 156889004254 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 156889004255 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 156889004256 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 156889004257 DNA methylase; Region: N6_N4_Mtase; pfam01555 156889004258 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 156889004259 RNase_H superfamily; Region: RNase_H_2; pfam13482 156889004260 AAA domain; Region: AAA_11; pfam13086 156889004261 Part of AAA domain; Region: AAA_19; pfam13245 156889004262 AAA domain; Region: AAA_12; pfam13087 156889004263 Predicted transcriptional regulator [Transcription]; Region: COG2378 156889004264 WYL domain; Region: WYL; pfam13280 156889004265 HD domain; Region: HD_3; cl17350 156889004266 AAA domain; Region: AAA_23; pfam13476 156889004267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889004268 Walker A/P-loop; other site 156889004269 ATP binding site [chemical binding]; other site 156889004270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889004271 ABC transporter signature motif; other site 156889004272 Walker B; other site 156889004273 D-loop; other site 156889004274 H-loop/switch region; other site 156889004275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889004276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889004277 ATP binding site [chemical binding]; other site 156889004278 Mg2+ binding site [ion binding]; other site 156889004279 G-X-G motif; other site 156889004280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004281 Response regulator receiver domain; Region: Response_reg; pfam00072 156889004282 active site 156889004283 phosphorylation site [posttranslational modification] 156889004284 intermolecular recognition site; other site 156889004285 dimerization interface [polypeptide binding]; other site 156889004286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 156889004287 DNA binding residues [nucleotide binding] 156889004288 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 156889004289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889004290 Walker A motif; other site 156889004291 ATP binding site [chemical binding]; other site 156889004292 Walker B motif; other site 156889004293 arginine finger; other site 156889004294 HTH domain; Region: HTH_11; cl17392 156889004295 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 156889004296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889004297 Walker A motif; other site 156889004298 ATP binding site [chemical binding]; other site 156889004299 Walker B motif; other site 156889004300 arginine finger; other site 156889004301 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 156889004302 active site 156889004303 catalytic triad [active] 156889004304 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 156889004305 Homeodomain-like domain; Region: HTH_32; pfam13565 156889004306 Integrase core domain; Region: rve; pfam00665 156889004307 Integrase core domain; Region: rve_3; pfam13683 156889004308 AAA domain; Region: AAA_24; pfam13479 156889004309 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 156889004310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889004311 ATP binding site [chemical binding]; other site 156889004312 putative Mg++ binding site [ion binding]; other site 156889004313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889004314 nucleotide binding region [chemical binding]; other site 156889004315 ATP-binding site [chemical binding]; other site 156889004316 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 156889004317 ORF6N domain; Region: ORF6N; pfam10543 156889004318 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 156889004319 active site 156889004320 metal binding site [ion binding]; metal-binding site 156889004321 interdomain interaction site; other site 156889004322 AAA domain; Region: AAA_25; pfam13481 156889004323 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 156889004324 Walker A motif; other site 156889004325 ATP binding site [chemical binding]; other site 156889004326 Walker B motif; other site 156889004327 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 156889004328 active site 156889004329 Heat induced stress protein YflT; Region: YflT; pfam11181 156889004330 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889004331 IHF dimer interface [polypeptide binding]; other site 156889004332 IHF - DNA interface [nucleotide binding]; other site 156889004333 Endonuclease I; Region: Endonuclease_1; pfam04231 156889004334 Peptidase M15; Region: Peptidase_M15_3; cl01194 156889004335 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 156889004336 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 156889004337 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 156889004338 active site 156889004339 ParB-like nuclease domain; Region: ParBc; pfam02195 156889004340 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 156889004341 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 156889004342 DNA methylase; Region: N6_N4_Mtase; cl17433 156889004343 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 156889004344 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 156889004345 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 156889004346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 156889004347 ATP binding site [chemical binding]; other site 156889004348 putative Mg++ binding site [ion binding]; other site 156889004349 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 156889004350 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 156889004351 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 156889004352 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 156889004353 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 156889004354 tandem repeat interface [polypeptide binding]; other site 156889004355 oligomer interface [polypeptide binding]; other site 156889004356 active site residues [active] 156889004357 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889004358 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889004359 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 156889004360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889004361 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 156889004362 salt bridge; other site 156889004363 non-specific DNA binding site [nucleotide binding]; other site 156889004364 sequence-specific DNA binding site [nucleotide binding]; other site 156889004365 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 156889004366 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 156889004367 Predicted GTPases [General function prediction only]; Region: COG1162 156889004368 Peptidase family M48; Region: Peptidase_M48; cl12018 156889004369 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 156889004370 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 156889004371 putative dimer interface [polypeptide binding]; other site 156889004372 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 156889004373 Part of AAA domain; Region: AAA_19; pfam13245 156889004374 Family description; Region: UvrD_C_2; pfam13538 156889004375 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 156889004376 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 156889004377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889004378 ATP binding site [chemical binding]; other site 156889004379 putative Mg++ binding site [ion binding]; other site 156889004380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889004381 ATP-binding site [chemical binding]; other site 156889004382 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 156889004383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889004384 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 156889004385 ATP binding site [chemical binding]; other site 156889004386 putative Mg++ binding site [ion binding]; other site 156889004387 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889004388 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 156889004389 nucleotide binding region [chemical binding]; other site 156889004390 ATP-binding site [chemical binding]; other site 156889004391 Predicted transcriptional regulator [Transcription]; Region: COG2378 156889004392 WYL domain; Region: WYL; pfam13280 156889004393 AAA domain; Region: AAA_23; pfam13476 156889004394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889004395 Walker A/P-loop; other site 156889004396 ATP binding site [chemical binding]; other site 156889004397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889004398 ABC transporter signature motif; other site 156889004399 Walker B; other site 156889004400 D-loop; other site 156889004401 H-loop/switch region; other site 156889004402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889004403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889004404 ATP binding site [chemical binding]; other site 156889004405 Mg2+ binding site [ion binding]; other site 156889004406 G-X-G motif; other site 156889004407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004408 Response regulator receiver domain; Region: Response_reg; pfam00072 156889004409 active site 156889004410 phosphorylation site [posttranslational modification] 156889004411 intermolecular recognition site; other site 156889004412 dimerization interface [polypeptide binding]; other site 156889004413 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 156889004414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889004415 Walker A motif; other site 156889004416 ATP binding site [chemical binding]; other site 156889004417 Walker B motif; other site 156889004418 arginine finger; other site 156889004419 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 156889004420 putative DNA binding site [nucleotide binding]; other site 156889004421 putative Zn2+ binding site [ion binding]; other site 156889004422 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 156889004423 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 156889004424 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 156889004425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889004426 non-specific DNA binding site [nucleotide binding]; other site 156889004427 salt bridge; other site 156889004428 sequence-specific DNA binding site [nucleotide binding]; other site 156889004429 Domain of unknown function (DUF955); Region: DUF955; cl01076 156889004430 Integrase core domain; Region: rve; pfam00665 156889004431 Integrase core domain; Region: rve_3; pfam13683 156889004432 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 156889004433 Integrase core domain; Region: rve; pfam00665 156889004434 DDE domain; Region: DDE_Tnp_IS240; pfam13610 156889004435 Integrase core domain; Region: rve_3; pfam13683 156889004436 Transposase; Region: HTH_Tnp_1; cl17663 156889004437 Winged helix-turn helix; Region: HTH_29; pfam13551 156889004438 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889004439 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889004440 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889004441 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 156889004442 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889004443 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889004444 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 156889004445 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 156889004446 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 156889004447 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889004448 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889004449 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889004450 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889004451 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889004452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 156889004453 binding surface 156889004454 TPR motif; other site 156889004455 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 156889004456 Zn binding site [ion binding]; other site 156889004457 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889004458 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889004459 ligand binding site [chemical binding]; other site 156889004460 flexible hinge region; other site 156889004461 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889004462 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889004463 metal binding site [ion binding]; metal-binding site 156889004464 active site 156889004465 I-site; other site 156889004466 ABC transporter ATPase component; Reviewed; Region: PRK11147 156889004467 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 156889004468 Walker A/P-loop; other site 156889004469 ATP binding site [chemical binding]; other site 156889004470 Q-loop/lid; other site 156889004471 ABC transporter signature motif; other site 156889004472 Walker B; other site 156889004473 D-loop; other site 156889004474 H-loop/switch region; other site 156889004475 ABC transporter; Region: ABC_tran_2; pfam12848 156889004476 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 156889004477 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 156889004478 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 156889004479 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 156889004480 active site 156889004481 glycogen branching enzyme; Provisional; Region: PRK05402 156889004482 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 156889004483 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 156889004484 active site 156889004485 catalytic site [active] 156889004486 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 156889004487 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 156889004488 catalytic motif [active] 156889004489 Zn binding site [ion binding]; other site 156889004490 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 156889004491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 156889004492 motif II; other site 156889004493 PilZ domain; Region: PilZ; pfam07238 156889004494 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 156889004495 heterotetramer interface [polypeptide binding]; other site 156889004496 active site pocket [active] 156889004497 cleavage site 156889004498 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 156889004499 active site 156889004500 8-oxo-dGMP binding site [chemical binding]; other site 156889004501 nudix motif; other site 156889004502 metal binding site [ion binding]; metal-binding site 156889004503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004504 active site 156889004505 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 156889004506 phosphorylation site [posttranslational modification] 156889004507 intermolecular recognition site; other site 156889004508 dimerization interface [polypeptide binding]; other site 156889004509 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889004510 metal binding site [ion binding]; metal-binding site 156889004511 active site 156889004512 I-site; other site 156889004513 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 156889004514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889004515 comF family protein; Region: comF; TIGR00201 156889004516 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 156889004517 active site 156889004518 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 156889004519 GSH binding site [chemical binding]; other site 156889004520 catalytic residues [active] 156889004521 nitrilase; Region: PLN02798 156889004522 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 156889004523 putative active site [active] 156889004524 catalytic triad [active] 156889004525 dimer interface [polypeptide binding]; other site 156889004526 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889004527 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889004528 metal binding site [ion binding]; metal-binding site 156889004529 active site 156889004530 I-site; other site 156889004531 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 156889004532 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 156889004533 NAD binding site [chemical binding]; other site 156889004534 substrate binding site [chemical binding]; other site 156889004535 homodimer interface [polypeptide binding]; other site 156889004536 active site 156889004537 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 156889004538 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 156889004539 substrate binding site; other site 156889004540 tetramer interface; other site 156889004541 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 156889004542 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 156889004543 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 156889004544 transmembrane helices; other site 156889004545 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 156889004546 TrkA-C domain; Region: TrkA_C; pfam02080 156889004547 TrkA-C domain; Region: TrkA_C; pfam02080 156889004548 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 156889004549 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 156889004550 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 156889004551 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 156889004552 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 156889004553 metal binding triad; other site 156889004554 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 156889004555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889004556 Zn2+ binding site [ion binding]; other site 156889004557 Mg2+ binding site [ion binding]; other site 156889004558 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 156889004559 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 156889004560 rod shape-determining protein MreB; Provisional; Region: PRK13927 156889004561 MreB and similar proteins; Region: MreB_like; cd10225 156889004562 nucleotide binding site [chemical binding]; other site 156889004563 Mg binding site [ion binding]; other site 156889004564 putative protofilament interaction site [polypeptide binding]; other site 156889004565 RodZ interaction site [polypeptide binding]; other site 156889004566 rod shape-determining protein MreC; Provisional; Region: PRK13922 156889004567 rod shape-determining protein MreC; Region: MreC; pfam04085 156889004568 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 156889004569 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 156889004570 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 156889004571 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 156889004572 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 156889004573 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 156889004574 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 156889004575 trimer interface [polypeptide binding]; other site 156889004576 active site 156889004577 UDP-GlcNAc binding site [chemical binding]; other site 156889004578 lipid binding site [chemical binding]; lipid-binding site 156889004579 Methyltransferase domain; Region: Methyltransf_31; pfam13847 156889004580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889004581 S-adenosylmethionine binding site [chemical binding]; other site 156889004582 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 156889004583 YcjX-like family, DUF463; Region: DUF463; pfam04317 156889004584 hypothetical protein; Provisional; Region: PRK05415 156889004585 Domain of unknown function (DUF697); Region: DUF697; pfam05128 156889004586 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 156889004587 homodimer interface [polypeptide binding]; other site 156889004588 substrate-cofactor binding pocket; other site 156889004589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889004590 catalytic residue [active] 156889004591 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 156889004592 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 156889004593 ligand binding site [chemical binding]; other site 156889004594 NAD binding site [chemical binding]; other site 156889004595 dimerization interface [polypeptide binding]; other site 156889004596 catalytic site [active] 156889004597 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 156889004598 putative L-serine binding site [chemical binding]; other site 156889004599 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 156889004600 Methyltransferase domain; Region: Methyltransf_23; pfam13489 156889004601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889004602 S-adenosylmethionine binding site [chemical binding]; other site 156889004603 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 156889004604 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 156889004605 Ligand binding site; other site 156889004606 Putative Catalytic site; other site 156889004607 DXD motif; other site 156889004608 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 156889004609 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 156889004610 NADP-binding site; other site 156889004611 homotetramer interface [polypeptide binding]; other site 156889004612 substrate binding site [chemical binding]; other site 156889004613 homodimer interface [polypeptide binding]; other site 156889004614 active site 156889004615 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889004616 Sel1-like repeats; Region: SEL1; smart00671 156889004617 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889004618 Sel1-like repeats; Region: SEL1; smart00671 156889004619 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889004620 Sel1-like repeats; Region: SEL1; smart00671 156889004621 Sel1-like repeats; Region: SEL1; smart00671 156889004622 Sel1-like repeats; Region: SEL1; smart00671 156889004623 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889004624 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889004625 Sel1-like repeats; Region: SEL1; smart00671 156889004626 pyruvate kinase; Provisional; Region: PRK05826 156889004627 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 156889004628 domain interfaces; other site 156889004629 active site 156889004630 4Fe-4S binding domain; Region: Fer4; pfam00037 156889004631 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 156889004632 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 156889004633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889004634 S-adenosylmethionine binding site [chemical binding]; other site 156889004635 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 156889004636 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 156889004637 active site 156889004638 (T/H)XGH motif; other site 156889004639 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 156889004640 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 156889004641 TRAM domain; Region: TRAM; pfam01938 156889004642 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 156889004643 PhoH-like protein; Region: PhoH; pfam02562 156889004644 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 156889004645 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 156889004646 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 156889004647 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889004648 Zn2+ binding site [ion binding]; other site 156889004649 Mg2+ binding site [ion binding]; other site 156889004650 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 156889004651 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 156889004652 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 156889004653 putative active site [active] 156889004654 catalytic triad [active] 156889004655 putative dimer interface [polypeptide binding]; other site 156889004656 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 156889004657 dimer interface [polypeptide binding]; other site 156889004658 motif 1; other site 156889004659 active site 156889004660 motif 2; other site 156889004661 motif 3; other site 156889004662 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 156889004663 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 156889004664 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889004665 ATP binding site [chemical binding]; other site 156889004666 putative Mg++ binding site [ion binding]; other site 156889004667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889004668 nucleotide binding region [chemical binding]; other site 156889004669 ATP-binding site [chemical binding]; other site 156889004670 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 156889004671 HRDC domain; Region: HRDC; pfam00570 156889004672 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 156889004673 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 156889004674 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 156889004675 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 156889004676 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 156889004677 trimer interface [polypeptide binding]; other site 156889004678 putative metal binding site [ion binding]; other site 156889004679 Sporulation related domain; Region: SPOR; pfam05036 156889004680 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 156889004681 MutS domain I; Region: MutS_I; pfam01624 156889004682 MutS domain II; Region: MutS_II; pfam05188 156889004683 MutS domain III; Region: MutS_III; pfam05192 156889004684 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 156889004685 Walker A/P-loop; other site 156889004686 ATP binding site [chemical binding]; other site 156889004687 Q-loop/lid; other site 156889004688 ABC transporter signature motif; other site 156889004689 Walker B; other site 156889004690 D-loop; other site 156889004691 H-loop/switch region; other site 156889004692 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889004693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 156889004694 TPR motif; other site 156889004695 Uncharacterized conserved protein [Function unknown]; Region: COG1262 156889004696 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 156889004697 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 156889004698 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 156889004699 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 156889004700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 156889004701 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889004702 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 156889004703 Protein of unknown function (DUF465); Region: DUF465; cl01070 156889004704 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 156889004705 Uncharacterized protein family (UPF0270); Region: UPF0270; pfam06794 156889004706 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 156889004707 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 156889004708 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 156889004709 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 156889004710 RNA binding site [nucleotide binding]; other site 156889004711 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 156889004712 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 156889004713 B12 binding domain; Region: B12-binding; pfam02310 156889004714 B12 binding site [chemical binding]; other site 156889004715 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 156889004716 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889004717 FeS/SAM binding site; other site 156889004718 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 156889004719 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 156889004720 Walker A/P-loop; other site 156889004721 ATP binding site [chemical binding]; other site 156889004722 Q-loop/lid; other site 156889004723 ABC transporter signature motif; other site 156889004724 Walker B; other site 156889004725 D-loop; other site 156889004726 H-loop/switch region; other site 156889004727 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 156889004728 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 156889004729 Walker A/P-loop; other site 156889004730 ATP binding site [chemical binding]; other site 156889004731 Q-loop/lid; other site 156889004732 ABC transporter signature motif; other site 156889004733 Walker B; other site 156889004734 D-loop; other site 156889004735 H-loop/switch region; other site 156889004736 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 156889004737 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 156889004738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 156889004739 dimer interface [polypeptide binding]; other site 156889004740 conserved gate region; other site 156889004741 putative PBP binding loops; other site 156889004742 ABC-ATPase subunit interface; other site 156889004743 Response regulator receiver domain; Region: Response_reg; pfam00072 156889004744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004745 active site 156889004746 phosphorylation site [posttranslational modification] 156889004747 intermolecular recognition site; other site 156889004748 dimerization interface [polypeptide binding]; other site 156889004749 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 156889004750 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 156889004751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889004752 Walker A/P-loop; other site 156889004753 ATP binding site [chemical binding]; other site 156889004754 Q-loop/lid; other site 156889004755 ABC transporter signature motif; other site 156889004756 Walker B; other site 156889004757 D-loop; other site 156889004758 H-loop/switch region; other site 156889004759 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 156889004760 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 156889004761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889004762 Walker A/P-loop; other site 156889004763 ATP binding site [chemical binding]; other site 156889004764 Q-loop/lid; other site 156889004765 ABC transporter signature motif; other site 156889004766 Walker B; other site 156889004767 D-loop; other site 156889004768 H-loop/switch region; other site 156889004769 Transglycosylase SLT domain; Region: SLT_2; pfam13406 156889004770 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 156889004771 N-acetyl-D-glucosamine binding site [chemical binding]; other site 156889004772 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 156889004773 rare lipoprotein A; Region: rlpA; TIGR00413 156889004774 Sporulation related domain; Region: SPOR; pfam05036 156889004775 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 156889004776 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 156889004777 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 156889004778 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 156889004779 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 156889004780 catalytic triad [active] 156889004781 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 156889004782 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 156889004783 HIGH motif; other site 156889004784 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 156889004785 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 156889004786 active site 156889004787 KMSKS motif; other site 156889004788 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 156889004789 tRNA binding surface [nucleotide binding]; other site 156889004790 anticodon binding site; other site 156889004791 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 156889004792 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 156889004793 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 156889004794 dimerization interface [polypeptide binding]; other site 156889004795 active site 156889004796 Biotin operon repressor [Transcription]; Region: BirA; COG1654 156889004797 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 156889004798 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 156889004799 pantothenate kinase; Reviewed; Region: PRK13318 156889004800 Sporulation related domain; Region: SPOR; pfam05036 156889004801 Sporulation related domain; Region: SPOR; pfam05036 156889004802 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 156889004803 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889004804 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889004805 dimer interface [polypeptide binding]; other site 156889004806 putative CheW interface [polypeptide binding]; other site 156889004807 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 156889004808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004809 active site 156889004810 phosphorylation site [posttranslational modification] 156889004811 intermolecular recognition site; other site 156889004812 dimerization interface [polypeptide binding]; other site 156889004813 CheB methylesterase; Region: CheB_methylest; pfam01339 156889004814 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 156889004815 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 156889004816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889004817 TPR motif; other site 156889004818 binding surface 156889004819 TPR repeat; Region: TPR_11; pfam13414 156889004820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889004821 TPR repeat; Region: TPR_11; pfam13414 156889004822 binding surface 156889004823 TPR motif; other site 156889004824 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889004825 putative binding surface; other site 156889004826 active site 156889004827 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 156889004828 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 156889004829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889004830 ATP binding site [chemical binding]; other site 156889004831 Mg2+ binding site [ion binding]; other site 156889004832 G-X-G motif; other site 156889004833 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 156889004834 Response regulator receiver domain; Region: Response_reg; pfam00072 156889004835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004836 active site 156889004837 phosphorylation site [posttranslational modification] 156889004838 intermolecular recognition site; other site 156889004839 dimerization interface [polypeptide binding]; other site 156889004840 Response regulator receiver domain; Region: Response_reg; pfam00072 156889004841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004842 active site 156889004843 phosphorylation site [posttranslational modification] 156889004844 intermolecular recognition site; other site 156889004845 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 156889004846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004847 active site 156889004848 phosphorylation site [posttranslational modification] 156889004849 intermolecular recognition site; other site 156889004850 dimerization interface [polypeptide binding]; other site 156889004851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004852 active site 156889004853 phosphorylation site [posttranslational modification] 156889004854 intermolecular recognition site; other site 156889004855 dimerization interface [polypeptide binding]; other site 156889004856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889004857 metal binding site [ion binding]; metal-binding site 156889004858 active site 156889004859 I-site; other site 156889004860 CheW-like domain; Region: CheW; pfam01584 156889004861 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 156889004862 PAS domain S-box; Region: sensory_box; TIGR00229 156889004863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889004864 putative active site [active] 156889004865 heme pocket [chemical binding]; other site 156889004866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889004867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889004868 ATP binding site [chemical binding]; other site 156889004869 Mg2+ binding site [ion binding]; other site 156889004870 G-X-G motif; other site 156889004871 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 156889004872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004873 active site 156889004874 phosphorylation site [posttranslational modification] 156889004875 intermolecular recognition site; other site 156889004876 dimerization interface [polypeptide binding]; other site 156889004877 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 156889004878 DNA binding site [nucleotide binding] 156889004879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889004880 dimerization interface [polypeptide binding]; other site 156889004881 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889004882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889004883 putative active site [active] 156889004884 heme pocket [chemical binding]; other site 156889004885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889004886 dimer interface [polypeptide binding]; other site 156889004887 phosphorylation site [posttranslational modification] 156889004888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889004889 ATP binding site [chemical binding]; other site 156889004890 Mg2+ binding site [ion binding]; other site 156889004891 G-X-G motif; other site 156889004892 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 156889004893 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 156889004894 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 156889004895 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 156889004896 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 156889004897 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 156889004898 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 156889004899 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 156889004900 MoaE homodimer interface [polypeptide binding]; other site 156889004901 MoaD interaction [polypeptide binding]; other site 156889004902 active site residues [active] 156889004903 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 156889004904 MPT binding site; other site 156889004905 trimer interface [polypeptide binding]; other site 156889004906 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 156889004907 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 156889004908 dimer interface [polypeptide binding]; other site 156889004909 putative functional site; other site 156889004910 putative MPT binding site; other site 156889004911 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 156889004912 trimer interface [polypeptide binding]; other site 156889004913 dimer interface [polypeptide binding]; other site 156889004914 putative active site [active] 156889004915 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 156889004916 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889004917 FeS/SAM binding site; other site 156889004918 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 156889004919 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 156889004920 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 156889004921 ATP binding site [chemical binding]; other site 156889004922 substrate interface [chemical binding]; other site 156889004923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889004924 non-specific DNA binding site [nucleotide binding]; other site 156889004925 salt bridge; other site 156889004926 Predicted transcriptional regulator [Transcription]; Region: COG2932 156889004927 sequence-specific DNA binding site [nucleotide binding]; other site 156889004928 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 156889004929 Catalytic site [active] 156889004930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889004931 S-adenosylmethionine binding site [chemical binding]; other site 156889004932 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 156889004933 dimerization interface [polypeptide binding]; other site 156889004934 putative DNA binding site [nucleotide binding]; other site 156889004935 putative Zn2+ binding site [ion binding]; other site 156889004936 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889004937 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889004938 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 156889004939 FAD binding site [chemical binding]; other site 156889004940 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 156889004941 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 156889004942 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 156889004943 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889004944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004945 active site 156889004946 phosphorylation site [posttranslational modification] 156889004947 intermolecular recognition site; other site 156889004948 dimerization interface [polypeptide binding]; other site 156889004949 PAS domain S-box; Region: sensory_box; TIGR00229 156889004950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889004951 putative active site [active] 156889004952 heme pocket [chemical binding]; other site 156889004953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889004954 PAS domain; Region: PAS_9; pfam13426 156889004955 putative active site [active] 156889004956 heme pocket [chemical binding]; other site 156889004957 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889004958 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889004959 metal binding site [ion binding]; metal-binding site 156889004960 active site 156889004961 I-site; other site 156889004962 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 156889004963 putative binding surface; other site 156889004964 active site 156889004965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 156889004966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889004967 active site 156889004968 phosphorylation site [posttranslational modification] 156889004969 intermolecular recognition site; other site 156889004970 dimerization interface [polypeptide binding]; other site 156889004971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 156889004972 DNA binding site [nucleotide binding] 156889004973 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 156889004974 putative active site [active] 156889004975 dimerization interface [polypeptide binding]; other site 156889004976 putative tRNAtyr binding site [nucleotide binding]; other site 156889004977 5-oxoprolinase; Region: PLN02666 156889004978 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 156889004979 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 156889004980 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 156889004981 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 156889004982 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 156889004983 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 156889004984 active site 156889004985 catalytic site [active] 156889004986 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 156889004987 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 156889004988 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 156889004989 glycogen synthase; Provisional; Region: glgA; PRK00654 156889004990 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 156889004991 ADP-binding pocket [chemical binding]; other site 156889004992 homodimer interface [polypeptide binding]; other site 156889004993 glycogen branching enzyme; Provisional; Region: PRK05402 156889004994 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 156889004995 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 156889004996 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 156889004997 active site 156889004998 catalytic site [active] 156889004999 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 156889005000 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 156889005001 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 156889005002 homodimer interface [polypeptide binding]; other site 156889005003 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 156889005004 active site pocket [active] 156889005005 glycogen synthase; Provisional; Region: glgA; PRK00654 156889005006 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 156889005007 ADP-binding pocket [chemical binding]; other site 156889005008 homodimer interface [polypeptide binding]; other site 156889005009 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 156889005010 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 156889005011 ligand binding site; other site 156889005012 oligomer interface; other site 156889005013 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 156889005014 dimer interface [polypeptide binding]; other site 156889005015 N-terminal domain interface [polypeptide binding]; other site 156889005016 sulfate 1 binding site; other site 156889005017 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 156889005018 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 156889005019 GDP-binding site [chemical binding]; other site 156889005020 ACT binding site; other site 156889005021 IMP binding site; other site 156889005022 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 156889005023 active site residue [active] 156889005024 HAMP domain; Region: HAMP; pfam00672 156889005025 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889005026 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889005027 dimer interface [polypeptide binding]; other site 156889005028 putative CheW interface [polypeptide binding]; other site 156889005029 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889005030 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889005031 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889005032 Response regulator receiver domain; Region: Response_reg; pfam00072 156889005033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889005034 active site 156889005035 phosphorylation site [posttranslational modification] 156889005036 intermolecular recognition site; other site 156889005037 dimerization interface [polypeptide binding]; other site 156889005038 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889005039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889005040 active site 156889005041 phosphorylation site [posttranslational modification] 156889005042 intermolecular recognition site; other site 156889005043 dimerization interface [polypeptide binding]; other site 156889005044 Response regulator receiver domain; Region: Response_reg; pfam00072 156889005045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889005046 active site 156889005047 phosphorylation site [posttranslational modification] 156889005048 intermolecular recognition site; other site 156889005049 dimerization interface [polypeptide binding]; other site 156889005050 cyclase homology domain; Region: CHD; cd07302 156889005051 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 156889005052 nucleotidyl binding site; other site 156889005053 metal binding site [ion binding]; metal-binding site 156889005054 dimer interface [polypeptide binding]; other site 156889005055 PilZ domain; Region: PilZ; pfam07238 156889005056 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 156889005057 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889005058 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889005059 ligand binding site [chemical binding]; other site 156889005060 flexible hinge region; other site 156889005061 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 156889005062 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889005063 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889005064 Sel1-like repeats; Region: SEL1; smart00671 156889005065 Sel1-like repeats; Region: SEL1; smart00671 156889005066 Sel1-like repeats; Region: SEL1; smart00671 156889005067 Sel1-like repeats; Region: SEL1; smart00671 156889005068 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889005069 Sel1-like repeats; Region: SEL1; smart00671 156889005070 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889005071 Sel1-like repeats; Region: SEL1; smart00671 156889005072 Sel1-like repeats; Region: SEL1; smart00671 156889005073 Sel1-like repeats; Region: SEL1; smart00671 156889005074 Sel1-like repeats; Region: SEL1; smart00671 156889005075 Sel1-like repeats; Region: SEL1; smart00671 156889005076 Sel1-like repeats; Region: SEL1; smart00671 156889005077 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889005078 Sel1-like repeats; Region: SEL1; smart00671 156889005079 Sel1-like repeats; Region: SEL1; smart00671 156889005080 Sel1-like repeats; Region: SEL1; smart00671 156889005081 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 156889005082 Rubredoxin; Region: Rubredoxin; pfam00301 156889005083 iron binding site [ion binding]; other site 156889005084 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 156889005085 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 156889005086 NAD binding site [chemical binding]; other site 156889005087 putative substrate binding site 2 [chemical binding]; other site 156889005088 putative substrate binding site 1 [chemical binding]; other site 156889005089 active site 156889005090 GAF domain; Region: GAF_3; pfam13492 156889005091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889005092 dimer interface [polypeptide binding]; other site 156889005093 phosphorylation site [posttranslational modification] 156889005094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889005095 ATP binding site [chemical binding]; other site 156889005096 Mg2+ binding site [ion binding]; other site 156889005097 G-X-G motif; other site 156889005098 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 156889005099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889005100 active site 156889005101 phosphorylation site [posttranslational modification] 156889005102 intermolecular recognition site; other site 156889005103 dimerization interface [polypeptide binding]; other site 156889005104 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 156889005105 Cache domain; Region: Cache_1; pfam02743 156889005106 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 156889005107 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 156889005108 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889005109 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 156889005110 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 156889005111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 156889005112 dimer interface [polypeptide binding]; other site 156889005113 conserved gate region; other site 156889005114 putative PBP binding loops; other site 156889005115 ABC-ATPase subunit interface; other site 156889005116 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 156889005117 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 156889005118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 156889005119 dimer interface [polypeptide binding]; other site 156889005120 conserved gate region; other site 156889005121 putative PBP binding loops; other site 156889005122 ABC-ATPase subunit interface; other site 156889005123 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 156889005124 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 156889005125 Walker A/P-loop; other site 156889005126 ATP binding site [chemical binding]; other site 156889005127 Q-loop/lid; other site 156889005128 ABC transporter signature motif; other site 156889005129 Walker B; other site 156889005130 D-loop; other site 156889005131 H-loop/switch region; other site 156889005132 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 156889005133 PhoU domain; Region: PhoU; pfam01895 156889005134 PhoU domain; Region: PhoU; pfam01895 156889005135 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 156889005136 active site residue [active] 156889005137 PBP superfamily domain; Region: PBP_like_2; pfam12849 156889005138 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 156889005139 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 156889005140 G1 box; other site 156889005141 putative GEF interaction site [polypeptide binding]; other site 156889005142 GTP/Mg2+ binding site [chemical binding]; other site 156889005143 Switch I region; other site 156889005144 G2 box; other site 156889005145 G3 box; other site 156889005146 Switch II region; other site 156889005147 G4 box; other site 156889005148 G5 box; other site 156889005149 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 156889005150 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 156889005151 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889005152 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 156889005153 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 156889005154 catalytic core [active] 156889005155 hypothetical protein; Provisional; Region: PRK08201 156889005156 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 156889005157 metal binding site [ion binding]; metal-binding site 156889005158 putative dimer interface [polypeptide binding]; other site 156889005159 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 156889005160 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 156889005161 putative metal binding site; other site 156889005162 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 156889005163 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 156889005164 putative active site [active] 156889005165 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 156889005166 putative acyl-acceptor binding pocket; other site 156889005167 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 156889005168 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 156889005169 putative active site [active] 156889005170 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 156889005171 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 156889005172 NADP binding site [chemical binding]; other site 156889005173 homopentamer interface [polypeptide binding]; other site 156889005174 substrate binding site [chemical binding]; other site 156889005175 active site 156889005176 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 156889005177 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 156889005178 putative ribose interaction site [chemical binding]; other site 156889005179 putative ADP binding site [chemical binding]; other site 156889005180 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 156889005181 active site 156889005182 nucleotide binding site [chemical binding]; other site 156889005183 HIGH motif; other site 156889005184 KMSKS motif; other site 156889005185 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 156889005186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 156889005187 active site 156889005188 motif I; other site 156889005189 motif II; other site 156889005190 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 156889005191 CTP synthetase; Validated; Region: pyrG; PRK05380 156889005192 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 156889005193 Catalytic site [active] 156889005194 active site 156889005195 UTP binding site [chemical binding]; other site 156889005196 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 156889005197 active site 156889005198 putative oxyanion hole; other site 156889005199 catalytic triad [active] 156889005200 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 156889005201 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 156889005202 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 156889005203 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 156889005204 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 156889005205 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 156889005206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889005207 tetramer interface [polypeptide binding]; other site 156889005208 catalytic residue [active] 156889005209 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 156889005210 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 156889005211 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 156889005212 catalytic residue [active] 156889005213 enolase; Provisional; Region: eno; PRK00077 156889005214 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 156889005215 dimer interface [polypeptide binding]; other site 156889005216 metal binding site [ion binding]; metal-binding site 156889005217 substrate binding pocket [chemical binding]; other site 156889005218 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889005219 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889005220 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 156889005221 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 156889005222 DNA binding residues [nucleotide binding] 156889005223 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 156889005224 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 156889005225 tandem repeat interface [polypeptide binding]; other site 156889005226 oligomer interface [polypeptide binding]; other site 156889005227 active site residues [active] 156889005228 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 156889005229 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 156889005230 substrate binding site [chemical binding]; other site 156889005231 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 156889005232 substrate binding site [chemical binding]; other site 156889005233 ligand binding site [chemical binding]; other site 156889005234 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 156889005235 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 156889005236 Zn binding site [ion binding]; other site 156889005237 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 156889005238 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 156889005239 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 156889005240 TrkA-N domain; Region: TrkA_N; pfam02254 156889005241 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 156889005242 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 156889005243 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 156889005244 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 156889005245 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 156889005246 HflK protein; Region: hflK; TIGR01933 156889005247 HflC protein; Region: hflC; TIGR01932 156889005248 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 156889005249 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 156889005250 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 156889005251 Predicted ATPase [General function prediction only]; Region: COG4637 156889005252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889005253 Walker A/P-loop; other site 156889005254 ATP binding site [chemical binding]; other site 156889005255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 156889005256 ABC transporter signature motif; other site 156889005257 Walker B; other site 156889005258 D-loop; other site 156889005259 H-loop/switch region; other site 156889005260 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 156889005261 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 156889005262 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 156889005263 putative [Fe4-S4] binding site [ion binding]; other site 156889005264 putative molybdopterin cofactor binding site [chemical binding]; other site 156889005265 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 156889005266 putative molybdopterin cofactor binding site; other site 156889005267 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 156889005268 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 156889005269 putative [Fe4-S4] binding site [ion binding]; other site 156889005270 putative molybdopterin cofactor binding site [chemical binding]; other site 156889005271 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 156889005272 putative molybdopterin cofactor binding site; other site 156889005273 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 156889005274 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 156889005275 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 156889005276 catalytic residue [active] 156889005277 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 156889005278 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 156889005279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889005280 dimerization interface [polypeptide binding]; other site 156889005281 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 156889005282 cyclase homology domain; Region: CHD; cd07302 156889005283 nucleotidyl binding site; other site 156889005284 metal binding site [ion binding]; metal-binding site 156889005285 dimer interface [polypeptide binding]; other site 156889005286 PBP superfamily domain; Region: PBP_like_2; cl17296 156889005287 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 156889005288 HAMP domain; Region: HAMP; pfam00672 156889005289 dimerization interface [polypeptide binding]; other site 156889005290 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889005291 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889005292 dimer interface [polypeptide binding]; other site 156889005293 putative CheW interface [polypeptide binding]; other site 156889005294 Hemerythrin; Region: Hemerythrin; cd12107 156889005295 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 156889005296 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 156889005297 putative active site [active] 156889005298 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 156889005299 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 156889005300 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 156889005301 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 156889005302 4Fe-4S binding domain; Region: Fer4_5; pfam12801 156889005303 4Fe-4S binding domain; Region: Fer4_5; pfam12801 156889005304 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 156889005305 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 156889005306 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 156889005307 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 156889005308 [4Fe-4S] binding site [ion binding]; other site 156889005309 molybdopterin cofactor binding site; other site 156889005310 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 156889005311 molybdopterin cofactor binding site; other site 156889005312 NapD protein; Region: NapD; pfam03927 156889005313 ferredoxin-type protein NapF; Region: napF; TIGR00402 156889005314 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 156889005315 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 156889005316 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889005317 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 156889005318 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 156889005319 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 156889005320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889005321 dimer interface [polypeptide binding]; other site 156889005322 phosphorylation site [posttranslational modification] 156889005323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889005324 ATP binding site [chemical binding]; other site 156889005325 Mg2+ binding site [ion binding]; other site 156889005326 G-X-G motif; other site 156889005327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 156889005328 active site 156889005329 phosphorylation site [posttranslational modification] 156889005330 dimerization interface [polypeptide binding]; other site 156889005331 Response regulator receiver domain; Region: Response_reg; pfam00072 156889005332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889005333 active site 156889005334 phosphorylation site [posttranslational modification] 156889005335 intermolecular recognition site; other site 156889005336 dimerization interface [polypeptide binding]; other site 156889005337 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 156889005338 putative binding surface; other site 156889005339 active site 156889005340 Protein of unknown function (DUF422); Region: DUF422; cl00991 156889005341 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 156889005342 putative inner membrane protein; Provisional; Region: PRK11099 156889005343 Sulphur transport; Region: Sulf_transp; pfam04143 156889005344 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 156889005345 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 156889005346 Helicase associated domain; Region: HA; pfam03457 156889005347 Helicase associated domain; Region: HA; pfam03457 156889005348 Helicase associated domain; Region: HA; pfam03457 156889005349 Helicase associated domain; Region: HA; pfam03457 156889005350 Helicase associated domain; Region: HA; pfam03457 156889005351 Helicase associated domain; Region: HA; pfam03457 156889005352 Helicase associated domain; Region: HA; pfam03457 156889005353 Helicase associated domain; Region: HA; pfam03457 156889005354 Helicase associated domain; Region: HA; pfam03457 156889005355 short chain dehydrogenase; Validated; Region: PRK08324 156889005356 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 156889005357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 156889005358 NAD(P) binding site [chemical binding]; other site 156889005359 active site 156889005360 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 156889005361 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 156889005362 putative active site; other site 156889005363 catalytic residue [active] 156889005364 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 156889005365 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 156889005366 Walker A motif; other site 156889005367 ATP binding site [chemical binding]; other site 156889005368 Walker B motif; other site 156889005369 recombinase A; Provisional; Region: recA; PRK09354 156889005370 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 156889005371 hexamer interface [polypeptide binding]; other site 156889005372 Walker A motif; other site 156889005373 ATP binding site [chemical binding]; other site 156889005374 Walker B motif; other site 156889005375 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 156889005376 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 156889005377 CAP-like domain; other site 156889005378 active site 156889005379 primary dimer interface [polypeptide binding]; other site 156889005380 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 156889005381 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 156889005382 DctM-like transporters; Region: DctM; pfam06808 156889005383 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 156889005384 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 156889005385 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 156889005386 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 156889005387 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 156889005388 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 156889005389 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 156889005390 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 156889005391 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 156889005392 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 156889005393 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 156889005394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889005395 binding surface 156889005396 TPR motif; other site 156889005397 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 156889005398 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 156889005399 DNA binding site [nucleotide binding] 156889005400 catalytic residue [active] 156889005401 H2TH interface [polypeptide binding]; other site 156889005402 putative catalytic residues [active] 156889005403 turnover-facilitating residue; other site 156889005404 intercalation triad [nucleotide binding]; other site 156889005405 8OG recognition residue [nucleotide binding]; other site 156889005406 putative reading head residues; other site 156889005407 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 156889005408 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 156889005409 PilZ domain; Region: PilZ; pfam07238 156889005410 Protein of unknown function, DUF399; Region: DUF399; pfam04187 156889005411 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 156889005412 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 156889005413 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889005414 Zn2+ binding site [ion binding]; other site 156889005415 Mg2+ binding site [ion binding]; other site 156889005416 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 156889005417 HD domain; Region: HD_4; pfam13328 156889005418 quinolinate synthetase; Provisional; Region: PRK09375 156889005419 epoxyqueuosine reductase; Region: TIGR00276 156889005420 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 156889005421 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 156889005422 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 156889005423 minor groove reading motif; other site 156889005424 helix-hairpin-helix signature motif; other site 156889005425 substrate binding pocket [chemical binding]; other site 156889005426 active site 156889005427 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 156889005428 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 156889005429 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 156889005430 putative [4Fe-4S] binding site [ion binding]; other site 156889005431 putative molybdopterin cofactor binding site [chemical binding]; other site 156889005432 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 156889005433 putative molybdopterin cofactor binding site; other site 156889005434 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 156889005435 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 156889005436 Protein of unknown function (DUF971); Region: DUF971; pfam06155 156889005437 B12 binding domain; Region: B12-binding; pfam02310 156889005438 B12 binding site [chemical binding]; other site 156889005439 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 156889005440 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889005441 FeS/SAM binding site; other site 156889005442 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 156889005443 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889005444 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 156889005445 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889005446 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 156889005447 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889005448 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 156889005449 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889005450 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 156889005451 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 156889005452 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 156889005453 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889005454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889005455 TPR motif; other site 156889005456 binding surface 156889005457 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889005458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889005459 binding surface 156889005460 TPR motif; other site 156889005461 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 156889005462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889005463 binding surface 156889005464 TPR motif; other site 156889005465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889005466 binding surface 156889005467 TPR motif; other site 156889005468 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 156889005469 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 156889005470 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 156889005471 Sulfate transporter family; Region: Sulfate_transp; pfam00916 156889005472 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 156889005473 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 156889005474 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889005475 Zn2+ binding site [ion binding]; other site 156889005476 Mg2+ binding site [ion binding]; other site 156889005477 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889005478 Zn2+ binding site [ion binding]; other site 156889005479 Mg2+ binding site [ion binding]; other site 156889005480 helicase 45; Provisional; Region: PTZ00424 156889005481 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 156889005482 ATP binding site [chemical binding]; other site 156889005483 Mg++ binding site [ion binding]; other site 156889005484 motif III; other site 156889005485 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889005486 nucleotide binding region [chemical binding]; other site 156889005487 ATP-binding site [chemical binding]; other site 156889005488 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 156889005489 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 156889005490 putative phosphate acyltransferase; Provisional; Region: PRK05331 156889005491 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 156889005492 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 156889005493 dimer interface [polypeptide binding]; other site 156889005494 active site 156889005495 CoA binding pocket [chemical binding]; other site 156889005496 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 156889005497 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889005498 substrate binding pocket [chemical binding]; other site 156889005499 membrane-bound complex binding site; other site 156889005500 hinge residues; other site 156889005501 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 156889005502 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 156889005503 N-acetyl-D-glucosamine binding site [chemical binding]; other site 156889005504 catalytic residue [active] 156889005505 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 156889005506 Hemerythrin-like domain; Region: Hr-like; cd12108 156889005507 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 156889005508 heme-binding site [chemical binding]; other site 156889005509 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889005510 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889005511 metal binding site [ion binding]; metal-binding site 156889005512 active site 156889005513 I-site; other site 156889005514 chaperone protein DnaJ; Provisional; Region: PRK14299 156889005515 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 156889005516 HSP70 interaction site [polypeptide binding]; other site 156889005517 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 156889005518 substrate binding site [polypeptide binding]; other site 156889005519 dimer interface [polypeptide binding]; other site 156889005520 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 156889005521 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 156889005522 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889005523 ATP binding site [chemical binding]; other site 156889005524 putative Mg++ binding site [ion binding]; other site 156889005525 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889005526 nucleotide binding region [chemical binding]; other site 156889005527 ATP-binding site [chemical binding]; other site 156889005528 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 156889005529 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 156889005530 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 156889005531 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889005532 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 156889005533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889005534 putative active site [active] 156889005535 heme pocket [chemical binding]; other site 156889005536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889005537 dimer interface [polypeptide binding]; other site 156889005538 phosphorylation site [posttranslational modification] 156889005539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889005540 ATP binding site [chemical binding]; other site 156889005541 Mg2+ binding site [ion binding]; other site 156889005542 G-X-G motif; other site 156889005543 Response regulator receiver domain; Region: Response_reg; pfam00072 156889005544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889005545 active site 156889005546 phosphorylation site [posttranslational modification] 156889005547 intermolecular recognition site; other site 156889005548 dimerization interface [polypeptide binding]; other site 156889005549 Methyltransferase domain; Region: Methyltransf_31; pfam13847 156889005550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889005551 S-adenosylmethionine binding site [chemical binding]; other site 156889005552 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889005553 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889005554 metal binding site [ion binding]; metal-binding site 156889005555 active site 156889005556 I-site; other site 156889005557 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 156889005558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889005559 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 156889005560 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 156889005561 active site 156889005562 Int/Topo IB signature motif; other site 156889005563 pteridine reductase; Provisional; Region: PRK09135 156889005564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 156889005565 NAD(P) binding site [chemical binding]; other site 156889005566 active site 156889005567 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 156889005568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889005569 Walker A motif; other site 156889005570 ATP binding site [chemical binding]; other site 156889005571 Walker B motif; other site 156889005572 arginine finger; other site 156889005573 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 156889005574 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 156889005575 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 156889005576 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 156889005577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 156889005578 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 156889005579 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 156889005580 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 156889005581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889005582 FeS/SAM binding site; other site 156889005583 recombination factor protein RarA; Reviewed; Region: PRK13342 156889005584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889005585 Walker A motif; other site 156889005586 ATP binding site [chemical binding]; other site 156889005587 Walker B motif; other site 156889005588 arginine finger; other site 156889005589 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 156889005590 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 156889005591 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 156889005592 DNA binding site [nucleotide binding] 156889005593 dimer interface [polypeptide binding]; other site 156889005594 active site 156889005595 Int/Topo IB signature motif; other site 156889005596 Uncharacterized conserved protein [Function unknown]; Region: COG1262 156889005597 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 156889005598 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 156889005599 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 156889005600 G1 box; other site 156889005601 putative GEF interaction site [polypeptide binding]; other site 156889005602 GTP/Mg2+ binding site [chemical binding]; other site 156889005603 Switch I region; other site 156889005604 G2 box; other site 156889005605 G3 box; other site 156889005606 Switch II region; other site 156889005607 G4 box; other site 156889005608 G5 box; other site 156889005609 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 156889005610 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 156889005611 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 156889005612 dimer interface [polypeptide binding]; other site 156889005613 decamer (pentamer of dimers) interface [polypeptide binding]; other site 156889005614 catalytic triad [active] 156889005615 peroxidatic and resolving cysteines [active] 156889005616 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 156889005617 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 156889005618 putative metal binding site [ion binding]; other site 156889005619 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 156889005620 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 156889005621 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 156889005622 putative FMN binding site [chemical binding]; other site 156889005623 Peptidase M15; Region: Peptidase_M15_3; cl01194 156889005624 Terminase-like family; Region: Terminase_6; pfam03237 156889005625 Phage terminase large subunit; Region: Terminase_3; cl12054 156889005626 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 156889005627 heat shock protein 90; Provisional; Region: PRK05218 156889005628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889005629 ATP binding site [chemical binding]; other site 156889005630 Mg2+ binding site [ion binding]; other site 156889005631 G-X-G motif; other site 156889005632 Protein of unknown function (DUF423); Region: DUF423; pfam04241 156889005633 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 156889005634 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 156889005635 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 156889005636 transmembrane helices; other site 156889005637 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 156889005638 Ligand Binding Site [chemical binding]; other site 156889005639 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 156889005640 Ligand Binding Site [chemical binding]; other site 156889005641 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 156889005642 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 156889005643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 156889005644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889005645 S-adenosylmethionine binding site [chemical binding]; other site 156889005646 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 156889005647 ferrochelatase; Reviewed; Region: hemH; PRK00035 156889005648 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 156889005649 C-terminal domain interface [polypeptide binding]; other site 156889005650 active site 156889005651 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 156889005652 active site 156889005653 N-terminal domain interface [polypeptide binding]; other site 156889005654 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 156889005655 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 156889005656 Walker A motif; other site 156889005657 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 156889005658 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 156889005659 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 156889005660 catalytic triad [active] 156889005661 DsrE/DsrF-like family; Region: DrsE; cl00672 156889005662 DsrE/DsrF-like family; Region: DrsE; cl00672 156889005663 DsrH like protein; Region: DsrH; pfam04077 156889005664 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 156889005665 4Fe-4S binding domain; Region: Fer4; cl02805 156889005666 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 156889005667 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 156889005668 Response regulator receiver domain; Region: Response_reg; pfam00072 156889005669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889005670 active site 156889005671 phosphorylation site [posttranslational modification] 156889005672 intermolecular recognition site; other site 156889005673 dimerization interface [polypeptide binding]; other site 156889005674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889005675 PAS domain; Region: PAS_9; pfam13426 156889005676 putative active site [active] 156889005677 heme pocket [chemical binding]; other site 156889005678 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889005679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889005680 metal binding site [ion binding]; metal-binding site 156889005681 active site 156889005682 I-site; other site 156889005683 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889005684 putative protease; Provisional; Region: PRK15452 156889005685 Peptidase family U32; Region: Peptidase_U32; pfam01136 156889005686 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 156889005687 FAD binding pocket [chemical binding]; other site 156889005688 conserved FAD binding motif [chemical binding]; other site 156889005689 phosphate binding motif [ion binding]; other site 156889005690 beta-alpha-beta structure motif; other site 156889005691 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889005692 binding surface 156889005693 TPR motif; other site 156889005694 TPR repeat; Region: TPR_11; pfam13414 156889005695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889005696 TPR motif; other site 156889005697 binding surface 156889005698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889005699 binding surface 156889005700 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889005701 TPR motif; other site 156889005702 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 156889005703 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 156889005704 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 156889005705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 156889005706 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 156889005707 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889005708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889005709 active site 156889005710 phosphorylation site [posttranslational modification] 156889005711 intermolecular recognition site; other site 156889005712 dimerization interface [polypeptide binding]; other site 156889005713 PAS domain S-box; Region: sensory_box; TIGR00229 156889005714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889005715 putative active site [active] 156889005716 heme pocket [chemical binding]; other site 156889005717 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 156889005718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 156889005719 binding surface 156889005720 TPR motif; other site 156889005721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889005722 binding surface 156889005723 TPR motif; other site 156889005724 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 156889005725 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 156889005726 transmembrane helices; other site 156889005727 TrkA-C domain; Region: TrkA_C; pfam02080 156889005728 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 156889005729 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 156889005730 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 156889005731 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 156889005732 G1 box; other site 156889005733 GTP/Mg2+ binding site [chemical binding]; other site 156889005734 Switch I region; other site 156889005735 G2 box; other site 156889005736 G3 box; other site 156889005737 Switch II region; other site 156889005738 G4 box; other site 156889005739 G5 box; other site 156889005740 Nucleoside recognition; Region: Gate; pfam07670 156889005741 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 156889005742 Nucleoside recognition; Region: Gate; pfam07670 156889005743 FeoA domain; Region: FeoA; pfam04023 156889005744 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 156889005745 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 156889005746 molybdenum-pterin binding domain; Region: Mop; TIGR00638 156889005747 molybdenum-pterin binding domain; Region: Mop; TIGR00638 156889005748 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 156889005749 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 156889005750 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889005751 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889005752 substrate binding pocket [chemical binding]; other site 156889005753 membrane-bound complex binding site; other site 156889005754 hinge residues; other site 156889005755 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889005756 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889005757 metal binding site [ion binding]; metal-binding site 156889005758 active site 156889005759 I-site; other site 156889005760 putative transporter; Provisional; Region: PRK11660 156889005761 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 156889005762 Sulfate transporter family; Region: Sulfate_transp; pfam00916 156889005763 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 156889005764 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 156889005765 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889005766 ligand binding site [chemical binding]; other site 156889005767 flexible hinge region; other site 156889005768 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889005769 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889005770 ligand binding site [chemical binding]; other site 156889005771 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 156889005772 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 156889005773 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 156889005774 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 156889005775 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 156889005776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889005777 Walker A motif; other site 156889005778 ATP binding site [chemical binding]; other site 156889005779 Walker B motif; other site 156889005780 arginine finger; other site 156889005781 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 156889005782 hypothetical protein; Validated; Region: PRK00153 156889005783 recombination protein RecR; Reviewed; Region: recR; PRK00076 156889005784 RecR protein; Region: RecR; pfam02132 156889005785 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 156889005786 putative active site [active] 156889005787 putative metal-binding site [ion binding]; other site 156889005788 tetramer interface [polypeptide binding]; other site 156889005789 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 156889005790 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 156889005791 dimer interface [polypeptide binding]; other site 156889005792 PYR/PP interface [polypeptide binding]; other site 156889005793 TPP binding site [chemical binding]; other site 156889005794 substrate binding site [chemical binding]; other site 156889005795 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 156889005796 4Fe-4S binding domain; Region: Fer4_6; pfam12837 156889005797 4Fe-4S binding domain; Region: Fer4; pfam00037 156889005798 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 156889005799 2-ketoisovalerate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11864 156889005800 TPP-binding site [chemical binding]; other site 156889005801 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 156889005802 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 156889005803 FAD binding domain; Region: FAD_binding_2; pfam00890 156889005804 L-aspartate oxidase; Provisional; Region: PRK06175 156889005805 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 156889005806 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 156889005807 CoA-ligase; Region: Ligase_CoA; pfam00549 156889005808 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 156889005809 CoA binding domain; Region: CoA_binding; smart00881 156889005810 CoA-ligase; Region: Ligase_CoA; pfam00549 156889005811 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 156889005812 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 156889005813 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 156889005814 dimer interface [polypeptide binding]; other site 156889005815 PYR/PP interface [polypeptide binding]; other site 156889005816 TPP binding site [chemical binding]; other site 156889005817 substrate binding site [chemical binding]; other site 156889005818 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 156889005819 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 156889005820 TPP-binding site [chemical binding]; other site 156889005821 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 156889005822 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 156889005823 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889005824 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889005825 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 156889005826 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 156889005827 adenylate kinase; Reviewed; Region: adk; PRK00279 156889005828 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 156889005829 AMP-binding site [chemical binding]; other site 156889005830 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 156889005831 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 156889005832 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 156889005833 aminotransferase; Validated; Region: PRK08175 156889005834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 156889005835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889005836 homodimer interface [polypeptide binding]; other site 156889005837 catalytic residue [active] 156889005838 homoserine dehydrogenase; Provisional; Region: PRK06349 156889005839 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 156889005840 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 156889005841 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 156889005842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 156889005843 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 156889005844 DHH family; Region: DHH; pfam01368 156889005845 DHHA1 domain; Region: DHHA1; pfam02272 156889005846 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889005847 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 156889005848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889005849 Walker A motif; other site 156889005850 ATP binding site [chemical binding]; other site 156889005851 Walker B motif; other site 156889005852 arginine finger; other site 156889005853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889005854 Walker A motif; other site 156889005855 ATP binding site [chemical binding]; other site 156889005856 Walker B motif; other site 156889005857 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 156889005858 Uncharacterized conserved protein [Function unknown]; Region: COG2127 156889005859 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 156889005860 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 156889005861 Walker A/P-loop; other site 156889005862 ATP binding site [chemical binding]; other site 156889005863 Q-loop/lid; other site 156889005864 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 156889005865 ABC transporter signature motif; other site 156889005866 Walker B; other site 156889005867 D-loop; other site 156889005868 H-loop/switch region; other site 156889005869 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 156889005870 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 156889005871 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 156889005872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889005873 Walker A motif; other site 156889005874 ATP binding site [chemical binding]; other site 156889005875 Walker B motif; other site 156889005876 putative GTP cyclohydrolase; Provisional; Region: PRK13674 156889005877 prolyl-tRNA synthetase; Provisional; Region: PRK09194 156889005878 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 156889005879 dimer interface [polypeptide binding]; other site 156889005880 motif 1; other site 156889005881 active site 156889005882 motif 2; other site 156889005883 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 156889005884 putative deacylase active site [active] 156889005885 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 156889005886 active site 156889005887 motif 3; other site 156889005888 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 156889005889 anticodon binding site; other site 156889005890 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 156889005891 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 156889005892 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 156889005893 L-aspartate oxidase; Provisional; Region: PRK09077 156889005894 L-aspartate oxidase; Provisional; Region: PRK06175 156889005895 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 156889005896 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 156889005897 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 156889005898 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 156889005899 DNA binding residues [nucleotide binding] 156889005900 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 156889005901 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 156889005902 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 156889005903 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 156889005904 protein binding site [polypeptide binding]; other site 156889005905 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 156889005906 protein binding site [polypeptide binding]; other site 156889005907 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 156889005908 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 156889005909 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 156889005910 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 156889005911 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 156889005912 RNA binding surface [nucleotide binding]; other site 156889005913 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 156889005914 active site 156889005915 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 156889005916 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 156889005917 motif II; other site 156889005918 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 156889005919 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 156889005920 substrate binding site [chemical binding]; other site 156889005921 ligand binding site [chemical binding]; other site 156889005922 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 156889005923 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 156889005924 substrate binding site [chemical binding]; other site 156889005925 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 156889005926 tartrate dehydrogenase; Region: TTC; TIGR02089 156889005927 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 156889005928 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 156889005929 FimV N-terminal domain; Region: FimV_core; TIGR03505 156889005930 Protein of unknown function DUF111; Region: DUF111; pfam01969 156889005931 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 156889005932 nudix motif; other site 156889005933 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 156889005934 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 156889005935 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 156889005936 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889005937 anti sigma factor interaction site; other site 156889005938 regulatory phosphorylation site [posttranslational modification]; other site 156889005939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889005940 dimerization interface [polypeptide binding]; other site 156889005941 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889005942 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889005943 dimer interface [polypeptide binding]; other site 156889005944 putative CheW interface [polypeptide binding]; other site 156889005945 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889005946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889005947 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889005948 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889005949 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889005950 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889005951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889005952 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 156889005953 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 156889005954 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 156889005955 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 156889005956 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 156889005957 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889005958 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889005959 substrate binding pocket [chemical binding]; other site 156889005960 membrane-bound complex binding site; other site 156889005961 hinge residues; other site 156889005962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889005963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889005964 phosphorylation site [posttranslational modification] 156889005965 dimer interface [polypeptide binding]; other site 156889005966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889005967 ATP binding site [chemical binding]; other site 156889005968 Mg2+ binding site [ion binding]; other site 156889005969 G-X-G motif; other site 156889005970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889005971 PAS domain; Region: PAS_9; pfam13426 156889005972 putative active site [active] 156889005973 heme pocket [chemical binding]; other site 156889005974 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889005975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889005976 metal binding site [ion binding]; metal-binding site 156889005977 active site 156889005978 I-site; other site 156889005979 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889005980 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889005981 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 156889005982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889005983 putative active site [active] 156889005984 heme pocket [chemical binding]; other site 156889005985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889005986 dimer interface [polypeptide binding]; other site 156889005987 phosphorylation site [posttranslational modification] 156889005988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889005989 ATP binding site [chemical binding]; other site 156889005990 Mg2+ binding site [ion binding]; other site 156889005991 G-X-G motif; other site 156889005992 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889005993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889005994 active site 156889005995 phosphorylation site [posttranslational modification] 156889005996 intermolecular recognition site; other site 156889005997 dimerization interface [polypeptide binding]; other site 156889005998 Predicted permeases [General function prediction only]; Region: COG0701 156889005999 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 156889006000 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 156889006001 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 156889006002 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 156889006003 molybdopterin cofactor binding site; other site 156889006004 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 156889006005 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 156889006006 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 156889006007 putative molybdopterin cofactor binding site; other site 156889006008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889006009 TPR repeat; Region: TPR_11; pfam13414 156889006010 binding surface 156889006011 TPR motif; other site 156889006012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889006013 binding surface 156889006014 TPR motif; other site 156889006015 TPR repeat; Region: TPR_11; pfam13414 156889006016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889006017 binding surface 156889006018 TPR motif; other site 156889006019 TPR repeat; Region: TPR_11; pfam13414 156889006020 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 156889006021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 156889006022 binding surface 156889006023 TPR motif; other site 156889006024 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889006025 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889006026 ligand binding site [chemical binding]; other site 156889006027 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 156889006028 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 156889006029 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889006030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006031 active site 156889006032 phosphorylation site [posttranslational modification] 156889006033 intermolecular recognition site; other site 156889006034 dimerization interface [polypeptide binding]; other site 156889006035 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 156889006036 putative active site [active] 156889006037 GIY-YIG motif/motif A; other site 156889006038 putative metal binding site [ion binding]; other site 156889006039 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 156889006040 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 156889006041 Walker A/P-loop; other site 156889006042 ATP binding site [chemical binding]; other site 156889006043 Q-loop/lid; other site 156889006044 ABC transporter signature motif; other site 156889006045 Walker B; other site 156889006046 D-loop; other site 156889006047 H-loop/switch region; other site 156889006048 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 156889006049 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 156889006050 putative MPT binding site; other site 156889006051 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 156889006052 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 156889006053 ligand binding site [chemical binding]; other site 156889006054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006055 active site 156889006056 phosphorylation site [posttranslational modification] 156889006057 intermolecular recognition site; other site 156889006058 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 156889006059 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889006060 Zn2+ binding site [ion binding]; other site 156889006061 Mg2+ binding site [ion binding]; other site 156889006062 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 156889006063 dimer interface [polypeptide binding]; other site 156889006064 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 156889006065 hydroxylamine reductase; Provisional; Region: PRK12310 156889006066 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 156889006067 ACS interaction site; other site 156889006068 CODH interaction site; other site 156889006069 metal cluster binding site [ion binding]; other site 156889006070 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 156889006071 Protein export membrane protein; Region: SecD_SecF; cl14618 156889006072 Protein export membrane protein; Region: SecD_SecF; cl14618 156889006073 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 156889006074 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889006075 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889006076 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 156889006077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 156889006078 HAMP domain; Region: HAMP; pfam00672 156889006079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 156889006080 putative active site [active] 156889006081 heme pocket [chemical binding]; other site 156889006082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889006083 dimer interface [polypeptide binding]; other site 156889006084 phosphorylation site [posttranslational modification] 156889006085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889006086 ATP binding site [chemical binding]; other site 156889006087 Mg2+ binding site [ion binding]; other site 156889006088 G-X-G motif; other site 156889006089 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889006090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006091 active site 156889006092 phosphorylation site [posttranslational modification] 156889006093 intermolecular recognition site; other site 156889006094 dimerization interface [polypeptide binding]; other site 156889006095 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 156889006096 cyclase homology domain; Region: CHD; cd07302 156889006097 nucleotidyl binding site; other site 156889006098 metal binding site [ion binding]; metal-binding site 156889006099 dimer interface [polypeptide binding]; other site 156889006100 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 156889006101 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 156889006102 homodimer interface [polypeptide binding]; other site 156889006103 substrate-cofactor binding pocket; other site 156889006104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889006105 catalytic residue [active] 156889006106 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 156889006107 Response regulator receiver domain; Region: Response_reg; pfam00072 156889006108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006109 active site 156889006110 phosphorylation site [posttranslational modification] 156889006111 intermolecular recognition site; other site 156889006112 dimerization interface [polypeptide binding]; other site 156889006113 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 156889006114 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 156889006115 TPR repeat; Region: TPR_11; pfam13414 156889006116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889006117 binding surface 156889006118 TPR motif; other site 156889006119 TPR repeat; Region: TPR_11; pfam13414 156889006120 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 156889006121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006122 active site 156889006123 phosphorylation site [posttranslational modification] 156889006124 intermolecular recognition site; other site 156889006125 dimerization interface [polypeptide binding]; other site 156889006126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889006127 PAS domain; Region: PAS_9; pfam13426 156889006128 putative active site [active] 156889006129 heme pocket [chemical binding]; other site 156889006130 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889006131 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889006132 metal binding site [ion binding]; metal-binding site 156889006133 active site 156889006134 I-site; other site 156889006135 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889006136 CheW-like domain; Region: CheW; pfam01584 156889006137 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 156889006138 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 156889006139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889006140 binding surface 156889006141 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889006142 TPR motif; other site 156889006143 CheW-like domain; Region: CheW; pfam01584 156889006144 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 156889006145 heme-binding site [chemical binding]; other site 156889006146 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 156889006147 dimerization interface [polypeptide binding]; other site 156889006148 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889006149 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889006150 dimer interface [polypeptide binding]; other site 156889006151 putative CheW interface [polypeptide binding]; other site 156889006152 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889006153 putative binding surface; other site 156889006154 active site 156889006155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889006156 ATP binding site [chemical binding]; other site 156889006157 Mg2+ binding site [ion binding]; other site 156889006158 G-X-G motif; other site 156889006159 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 156889006160 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889006161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006162 active site 156889006163 phosphorylation site [posttranslational modification] 156889006164 intermolecular recognition site; other site 156889006165 dimerization interface [polypeptide binding]; other site 156889006166 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 156889006167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006168 active site 156889006169 phosphorylation site [posttranslational modification] 156889006170 intermolecular recognition site; other site 156889006171 dimerization interface [polypeptide binding]; other site 156889006172 CheB methylesterase; Region: CheB_methylest; pfam01339 156889006173 Acylphosphatase; Region: Acylphosphatase; pfam00708 156889006174 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 156889006175 HypF finger; Region: zf-HYPF; pfam07503 156889006176 HypF finger; Region: zf-HYPF; pfam07503 156889006177 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 156889006178 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 156889006179 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 156889006180 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 156889006181 rRNA interaction site [nucleotide binding]; other site 156889006182 S8 interaction site; other site 156889006183 putative laminin-1 binding site; other site 156889006184 elongation factor Ts; Provisional; Region: tsf; PRK09377 156889006185 UBA/TS-N domain; Region: UBA; pfam00627 156889006186 Elongation factor TS; Region: EF_TS; pfam00889 156889006187 Elongation factor TS; Region: EF_TS; pfam00889 156889006188 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 156889006189 putative nucleotide binding site [chemical binding]; other site 156889006190 uridine monophosphate binding site [chemical binding]; other site 156889006191 homohexameric interface [polypeptide binding]; other site 156889006192 ribosome recycling factor; Reviewed; Region: frr; PRK00083 156889006193 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 156889006194 hinge region; other site 156889006195 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 156889006196 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 156889006197 catalytic residue [active] 156889006198 putative FPP diphosphate binding site; other site 156889006199 putative FPP binding hydrophobic cleft; other site 156889006200 dimer interface [polypeptide binding]; other site 156889006201 putative IPP diphosphate binding site; other site 156889006202 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 156889006203 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 156889006204 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 156889006205 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 156889006206 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 156889006207 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 156889006208 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 156889006209 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 156889006210 active site 156889006211 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 156889006212 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 156889006213 putative substrate binding region [chemical binding]; other site 156889006214 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 156889006215 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 156889006216 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 156889006217 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 156889006218 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 156889006219 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 156889006220 Surface antigen; Region: Bac_surface_Ag; pfam01103 156889006221 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 156889006222 periplasmic chaperone; Provisional; Region: PRK10780 156889006223 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 156889006224 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 156889006225 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 156889006226 active site 156889006227 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 156889006228 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 156889006229 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 156889006230 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 156889006231 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 156889006232 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 156889006233 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 156889006234 catalytic residues [active] 156889006235 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 156889006236 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 156889006237 active site 156889006238 HIGH motif; other site 156889006239 KMSKS motif; other site 156889006240 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 156889006241 anticodon binding site; other site 156889006242 tRNA binding surface [nucleotide binding]; other site 156889006243 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 156889006244 dimer interface [polypeptide binding]; other site 156889006245 putative tRNA-binding site [nucleotide binding]; other site 156889006246 GAF domain; Region: GAF; pfam01590 156889006247 GAF domain; Region: GAF; pfam01590 156889006248 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889006249 Zn2+ binding site [ion binding]; other site 156889006250 Mg2+ binding site [ion binding]; other site 156889006251 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889006252 CHASE2 domain; Region: CHASE2; pfam05226 156889006253 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 156889006254 cyclase homology domain; Region: CHD; cd07302 156889006255 nucleotidyl binding site; other site 156889006256 metal binding site [ion binding]; metal-binding site 156889006257 dimer interface [polypeptide binding]; other site 156889006258 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 156889006259 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 156889006260 active site 156889006261 hydrophilic channel; other site 156889006262 dimerization interface [polypeptide binding]; other site 156889006263 catalytic residues [active] 156889006264 active site lid [active] 156889006265 Protein of unknown function; Region: DUF3971; pfam13116 156889006266 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 156889006267 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 156889006268 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 156889006269 metal binding triad; other site 156889006270 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 156889006271 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 156889006272 metal binding triad; other site 156889006273 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 156889006274 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 156889006275 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 156889006276 homodimer interface [polypeptide binding]; other site 156889006277 substrate-cofactor binding pocket; other site 156889006278 catalytic residue [active] 156889006279 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 156889006280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889006281 Walker A/P-loop; other site 156889006282 ATP binding site [chemical binding]; other site 156889006283 Q-loop/lid; other site 156889006284 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 156889006285 ABC transporter; Region: ABC_tran_2; pfam12848 156889006286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 156889006287 superantigen-like protein; Reviewed; Region: PRK13042 156889006288 PilZ domain; Region: PilZ; pfam07238 156889006289 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 156889006290 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 156889006291 active site 156889006292 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 156889006293 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889006294 FeS/SAM binding site; other site 156889006295 PSP1 C-terminal conserved region; Region: PSP1; cl00770 156889006296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 156889006297 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 156889006298 Walker A motif; other site 156889006299 ATP binding site [chemical binding]; other site 156889006300 DNA polymerase III subunit delta'; Validated; Region: PRK08485 156889006301 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 156889006302 thymidylate kinase; Validated; Region: tmk; PRK00698 156889006303 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 156889006304 TMP-binding site; other site 156889006305 ATP-binding site [chemical binding]; other site 156889006306 YceG-like family; Region: YceG; pfam02618 156889006307 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 156889006308 dimerization interface [polypeptide binding]; other site 156889006309 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 156889006310 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 156889006311 dimer interface [polypeptide binding]; other site 156889006312 active site 156889006313 acyl carrier protein; Provisional; Region: acpP; PRK00982 156889006314 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 156889006315 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 156889006316 NAD(P) binding site [chemical binding]; other site 156889006317 homotetramer interface [polypeptide binding]; other site 156889006318 homodimer interface [polypeptide binding]; other site 156889006319 active site 156889006320 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 156889006321 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 156889006322 Uncharacterized conserved protein [Function unknown]; Region: COG1432 156889006323 LabA_like proteins; Region: LabA; cd10911 156889006324 putative metal binding site [ion binding]; other site 156889006325 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 156889006326 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 156889006327 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 156889006328 GIY-YIG motif/motif A; other site 156889006329 active site 156889006330 catalytic site [active] 156889006331 putative DNA binding site [nucleotide binding]; other site 156889006332 metal binding site [ion binding]; metal-binding site 156889006333 UvrB/uvrC motif; Region: UVR; pfam02151 156889006334 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 156889006335 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 156889006336 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 156889006337 Prephenate dehydratase; Region: PDT; pfam00800 156889006338 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 156889006339 putative L-Phe binding site [chemical binding]; other site 156889006340 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 156889006341 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 156889006342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889006343 ATP binding site [chemical binding]; other site 156889006344 putative Mg++ binding site [ion binding]; other site 156889006345 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889006346 nucleotide binding region [chemical binding]; other site 156889006347 ATP-binding site [chemical binding]; other site 156889006348 Helicase associated domain (HA2); Region: HA2; pfam04408 156889006349 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 156889006350 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 156889006351 Preprotein translocase SecG subunit; Region: SecG; pfam03840 156889006352 triosephosphate isomerase; Provisional; Region: PRK14565 156889006353 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 156889006354 substrate binding site [chemical binding]; other site 156889006355 dimer interface [polypeptide binding]; other site 156889006356 catalytic triad [active] 156889006357 Phosphoglycerate kinase; Region: PGK; pfam00162 156889006358 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 156889006359 substrate binding site [chemical binding]; other site 156889006360 hinge regions; other site 156889006361 ADP binding site [chemical binding]; other site 156889006362 catalytic site [active] 156889006363 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 156889006364 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 156889006365 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 156889006366 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 156889006367 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 156889006368 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 156889006369 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 156889006370 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 156889006371 ATP-grasp domain; Region: ATP-grasp_4; cl17255 156889006372 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 156889006373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006374 active site 156889006375 phosphorylation site [posttranslational modification] 156889006376 intermolecular recognition site; other site 156889006377 dimerization interface [polypeptide binding]; other site 156889006378 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 156889006379 DNA binding site [nucleotide binding] 156889006380 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 156889006381 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889006382 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 156889006383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889006384 dimerization interface [polypeptide binding]; other site 156889006385 PAS domain S-box; Region: sensory_box; TIGR00229 156889006386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889006387 putative active site [active] 156889006388 heme pocket [chemical binding]; other site 156889006389 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889006390 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889006391 metal binding site [ion binding]; metal-binding site 156889006392 active site 156889006393 I-site; other site 156889006394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889006395 TPR motif; other site 156889006396 binding surface 156889006397 TPR repeat; Region: TPR_11; pfam13414 156889006398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889006399 binding surface 156889006400 TPR motif; other site 156889006401 TPR repeat; Region: TPR_11; pfam13414 156889006402 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 156889006403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006404 active site 156889006405 phosphorylation site [posttranslational modification] 156889006406 intermolecular recognition site; other site 156889006407 dimerization interface [polypeptide binding]; other site 156889006408 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 156889006409 DNA binding site [nucleotide binding] 156889006410 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 156889006411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889006412 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 156889006413 dimer interface [polypeptide binding]; other site 156889006414 phosphorylation site [posttranslational modification] 156889006415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889006416 ATP binding site [chemical binding]; other site 156889006417 Mg2+ binding site [ion binding]; other site 156889006418 G-X-G motif; other site 156889006419 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 156889006420 phosphate binding site [ion binding]; other site 156889006421 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 156889006422 active site residue [active] 156889006423 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889006424 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889006425 dimer interface [polypeptide binding]; other site 156889006426 putative CheW interface [polypeptide binding]; other site 156889006427 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 156889006428 active site 156889006429 metal binding site [ion binding]; metal-binding site 156889006430 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 156889006431 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 156889006432 Cytochrome c; Region: Cytochrom_C; pfam00034 156889006433 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 156889006434 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 156889006435 hypothetical protein; Validated; Region: PRK00124 156889006436 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 156889006437 DNA-binding site [nucleotide binding]; DNA binding site 156889006438 RNA-binding motif; other site 156889006439 Uncharacterized conserved protein [Function unknown]; Region: COG5316 156889006440 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 156889006441 Hepatocyte nuclear factor 1 (HNF-1), N terminus; Region: HNF-1_N; pfam04814 156889006442 Transcriptional regulator [Transcription]; Region: IclR; COG1414 156889006443 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 156889006444 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 156889006445 active site 156889006446 putative substrate binding pocket [chemical binding]; other site 156889006447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889006448 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 156889006449 Walker A motif; other site 156889006450 ATP binding site [chemical binding]; other site 156889006451 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889006452 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889006453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889006454 binding surface 156889006455 TPR motif; other site 156889006456 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889006457 6-phosphofructokinase; Provisional; Region: PRK14072 156889006458 active site 156889006459 ADP/pyrophosphate binding site [chemical binding]; other site 156889006460 dimerization interface [polypeptide binding]; other site 156889006461 allosteric effector site; other site 156889006462 fructose-1,6-bisphosphate binding site; other site 156889006463 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 156889006464 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 156889006465 FAD binding domain; Region: FAD_binding_4; pfam01565 156889006466 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 156889006467 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 156889006468 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 156889006469 Cysteine-rich domain; Region: CCG; pfam02754 156889006470 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 156889006471 aminopeptidase N; Provisional; Region: pepN; PRK14015 156889006472 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 156889006473 active site 156889006474 Zn binding site [ion binding]; other site 156889006475 PilZ domain; Region: PilZ; pfam07238 156889006476 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 156889006477 Catalytic domain of Protein Kinases; Region: PKc; cd00180 156889006478 active site 156889006479 ATP binding site [chemical binding]; other site 156889006480 substrate binding site [chemical binding]; other site 156889006481 activation loop (A-loop); other site 156889006482 Uncharacterized conserved protein [Function unknown]; Region: COG1262 156889006483 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 156889006484 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889006485 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 156889006486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 156889006487 Uncharacterized conserved protein [Function unknown]; Region: COG4198 156889006488 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 156889006489 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 156889006490 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 156889006491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889006492 dimerization interface [polypeptide binding]; other site 156889006493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889006494 putative active site [active] 156889006495 heme pocket [chemical binding]; other site 156889006496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889006497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889006498 dimer interface [polypeptide binding]; other site 156889006499 phosphorylation site [posttranslational modification] 156889006500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889006501 ATP binding site [chemical binding]; other site 156889006502 Mg2+ binding site [ion binding]; other site 156889006503 G-X-G motif; other site 156889006504 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889006505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006506 active site 156889006507 phosphorylation site [posttranslational modification] 156889006508 intermolecular recognition site; other site 156889006509 dimerization interface [polypeptide binding]; other site 156889006510 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 156889006511 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 156889006512 active site 156889006513 Protein of unknown function (DUF805); Region: DUF805; pfam05656 156889006514 Protein of unknown function (DUF523); Region: DUF523; pfam04463 156889006515 Uncharacterized conserved protein [Function unknown]; Region: COG3272 156889006516 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 156889006517 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 156889006518 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 156889006519 active site 156889006520 dimer interface [polypeptide binding]; other site 156889006521 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 156889006522 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 156889006523 dimer interface [polypeptide binding]; other site 156889006524 active site 156889006525 endonuclease IV; Provisional; Region: PRK01060 156889006526 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 156889006527 AP (apurinic/apyrimidinic) site pocket; other site 156889006528 DNA interaction; other site 156889006529 Metal-binding active site; metal-binding site 156889006530 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 156889006531 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 156889006532 active site 156889006533 NTP binding site [chemical binding]; other site 156889006534 metal binding triad [ion binding]; metal-binding site 156889006535 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 156889006536 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 156889006537 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 156889006538 homodimer interface [polypeptide binding]; other site 156889006539 substrate-cofactor binding pocket; other site 156889006540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889006541 catalytic residue [active] 156889006542 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 156889006543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889006544 S-adenosylmethionine binding site [chemical binding]; other site 156889006545 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 156889006546 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 156889006547 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 156889006548 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 156889006549 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 156889006550 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 156889006551 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 156889006552 ligand binding site [chemical binding]; other site 156889006553 PilZ domain; Region: PilZ; pfam07238 156889006554 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 156889006555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889006556 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889006557 putative active site [active] 156889006558 heme pocket [chemical binding]; other site 156889006559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889006560 putative active site [active] 156889006561 heme pocket [chemical binding]; other site 156889006562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889006563 PAS domain; Region: PAS_9; pfam13426 156889006564 putative active site [active] 156889006565 heme pocket [chemical binding]; other site 156889006566 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889006567 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889006568 metal binding site [ion binding]; metal-binding site 156889006569 active site 156889006570 I-site; other site 156889006571 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889006572 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 156889006573 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 156889006574 catalytic residues [active] 156889006575 Protein kinase domain; Region: Pkinase; pfam00069 156889006576 Catalytic domain of Protein Kinases; Region: PKc; cd00180 156889006577 active site 156889006578 ATP binding site [chemical binding]; other site 156889006579 substrate binding site [chemical binding]; other site 156889006580 activation loop (A-loop); other site 156889006581 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889006582 Sel1-like repeats; Region: SEL1; smart00671 156889006583 Sel1-like repeats; Region: SEL1; smart00671 156889006584 Sel1-like repeats; Region: SEL1; smart00671 156889006585 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 156889006586 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 156889006587 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 156889006588 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 156889006589 Peptidase family M23; Region: Peptidase_M23; pfam01551 156889006590 Uncharacterized conserved protein [Function unknown]; Region: COG0432 156889006591 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 156889006592 Ligand binding site; other site 156889006593 Putative Catalytic site; other site 156889006594 DXD motif; other site 156889006595 Methyltransferase domain; Region: Methyltransf_23; pfam13489 156889006596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889006597 S-adenosylmethionine binding site [chemical binding]; other site 156889006598 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 156889006599 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 156889006600 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 156889006601 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889006602 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889006603 Transposase IS200 like; Region: Y1_Tnp; pfam01797 156889006604 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 156889006605 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889006606 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889006607 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 156889006608 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 156889006609 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 156889006610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889006611 Walker A/P-loop; other site 156889006612 ATP binding site [chemical binding]; other site 156889006613 Q-loop/lid; other site 156889006614 ABC transporter signature motif; other site 156889006615 Walker B; other site 156889006616 D-loop; other site 156889006617 H-loop/switch region; other site 156889006618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 156889006619 Integrase core domain; Region: rve; pfam00665 156889006620 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889006621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889006622 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889006623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889006624 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889006625 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889006626 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889006627 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 156889006628 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 156889006629 putative active site [active] 156889006630 putative NTP binding site [chemical binding]; other site 156889006631 putative nucleic acid binding site [nucleotide binding]; other site 156889006632 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 156889006633 HTH-like domain; Region: HTH_21; pfam13276 156889006634 Integrase core domain; Region: rve; pfam00665 156889006635 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889006636 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889006637 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889006638 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 156889006639 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889006640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889006641 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889006642 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889006643 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889006644 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889006645 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 156889006646 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 156889006647 putative active site [active] 156889006648 putative NTP binding site [chemical binding]; other site 156889006649 putative nucleic acid binding site [nucleotide binding]; other site 156889006650 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 156889006651 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889006652 Transposase; Region: HTH_Tnp_1; pfam01527 156889006653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 156889006654 putative transposase OrfB; Reviewed; Region: PHA02517 156889006655 HTH-like domain; Region: HTH_21; pfam13276 156889006656 Integrase core domain; Region: rve; pfam00665 156889006657 Integrase core domain; Region: rve_3; pfam13683 156889006658 HTH-like domain; Region: HTH_21; pfam13276 156889006659 Integrase core domain; Region: rve; pfam00665 156889006660 Transposase; Region: HTH_Tnp_1; pfam01527 156889006661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 156889006662 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889006663 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 156889006664 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 156889006665 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 156889006666 ADP-ribose binding site [chemical binding]; other site 156889006667 putative active site [active] 156889006668 dimer interface [polypeptide binding]; other site 156889006669 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 156889006670 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 156889006671 putative active site [active] 156889006672 putative metal binding site [ion binding]; other site 156889006673 Uncharacterized conserved protein [Function unknown]; Region: COG1262 156889006674 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 156889006675 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889006676 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 156889006677 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 156889006678 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889006679 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 156889006680 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889006681 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 156889006682 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889006683 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889006684 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 156889006685 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 156889006686 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 156889006687 active site 156889006688 metal binding site [ion binding]; metal-binding site 156889006689 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 156889006690 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 156889006691 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889006692 Sel1-like repeats; Region: SEL1; smart00671 156889006693 Sel1-like repeats; Region: SEL1; smart00671 156889006694 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889006695 Sel1-like repeats; Region: SEL1; smart00671 156889006696 Sel1-like repeats; Region: SEL1; smart00671 156889006697 Sel1-like repeats; Region: SEL1; smart00671 156889006698 Sel1-like repeats; Region: SEL1; smart00671 156889006699 Sel1-like repeats; Region: SEL1; smart00671 156889006700 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889006701 Sel1-like repeats; Region: SEL1; smart00671 156889006702 Sel1-like repeats; Region: SEL1; smart00671 156889006703 Sel1-like repeats; Region: SEL1; smart00671 156889006704 Sel1-like repeats; Region: SEL1; smart00671 156889006705 Sel1-like repeats; Region: SEL1; smart00671 156889006706 Sel1-like repeats; Region: SEL1; smart00671 156889006707 Sel1-like repeats; Region: SEL1; smart00671 156889006708 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 156889006709 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 156889006710 N-acetyl-D-glucosamine binding site [chemical binding]; other site 156889006711 catalytic residue [active] 156889006712 Uncharacterized conserved protein [Function unknown]; Region: COG4715 156889006713 SWIM zinc finger; Region: SWIM; pfam04434 156889006714 WYL domain; Region: WYL; pfam13280 156889006715 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 156889006716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889006717 ATP binding site [chemical binding]; other site 156889006718 putative Mg++ binding site [ion binding]; other site 156889006719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889006720 ATP-binding site [chemical binding]; other site 156889006721 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 156889006722 DEAD-like helicases superfamily; Region: DEXDc; smart00487 156889006723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889006724 ATP binding site [chemical binding]; other site 156889006725 putative Mg++ binding site [ion binding]; other site 156889006726 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 156889006727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889006728 nucleotide binding region [chemical binding]; other site 156889006729 ATP-binding site [chemical binding]; other site 156889006730 Methyltransferase domain; Region: Methyltransf_26; pfam13659 156889006731 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 156889006732 Protein of unknown function (DUF511); Region: DUF511; cl01114 156889006733 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 156889006734 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 156889006735 putative dimer interface [polypeptide binding]; other site 156889006736 Peptidase family M48; Region: Peptidase_M48; cl12018 156889006737 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 156889006738 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 156889006739 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 156889006740 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 156889006741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 156889006742 salt bridge; other site 156889006743 non-specific DNA binding site [nucleotide binding]; other site 156889006744 sequence-specific DNA binding site [nucleotide binding]; other site 156889006745 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 156889006746 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889006747 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889006748 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 156889006749 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 156889006750 tandem repeat interface [polypeptide binding]; other site 156889006751 oligomer interface [polypeptide binding]; other site 156889006752 active site residues [active] 156889006753 Response regulator receiver domain; Region: Response_reg; pfam00072 156889006754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006755 active site 156889006756 phosphorylation site [posttranslational modification] 156889006757 intermolecular recognition site; other site 156889006758 dimerization interface [polypeptide binding]; other site 156889006759 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 156889006760 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 156889006761 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 156889006762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 156889006763 ATP binding site [chemical binding]; other site 156889006764 putative Mg++ binding site [ion binding]; other site 156889006765 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 156889006766 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 156889006767 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889006768 IHF dimer interface [polypeptide binding]; other site 156889006769 IHF - DNA interface [nucleotide binding]; other site 156889006770 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 156889006771 ParB-like nuclease domain; Region: ParBc; pfam02195 156889006772 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 156889006773 DNA methylase; Region: N6_N4_Mtase; cl17433 156889006774 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 156889006775 active site 156889006776 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 156889006777 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 156889006778 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889006779 IHF dimer interface [polypeptide binding]; other site 156889006780 IHF - DNA interface [nucleotide binding]; other site 156889006781 Peptidase M15; Region: Peptidase_M15_3; cl01194 156889006782 DNA-specific endonuclease I; Provisional; Region: PRK15137 156889006783 Endonuclease I; Region: Endonuclease_1; pfam04231 156889006784 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889006785 IHF dimer interface [polypeptide binding]; other site 156889006786 IHF - DNA interface [nucleotide binding]; other site 156889006787 Heat induced stress protein YflT; Region: YflT; pfam11181 156889006788 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 156889006789 active site 156889006790 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 156889006791 active site 156889006792 metal binding site [ion binding]; metal-binding site 156889006793 interdomain interaction site; other site 156889006794 AAA domain; Region: AAA_25; pfam13481 156889006795 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 156889006796 Walker A motif; other site 156889006797 ATP binding site [chemical binding]; other site 156889006798 Walker B motif; other site 156889006799 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 156889006800 ORF6N domain; Region: ORF6N; pfam10543 156889006801 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 156889006802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889006803 ATP binding site [chemical binding]; other site 156889006804 putative Mg++ binding site [ion binding]; other site 156889006805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889006806 nucleotide binding region [chemical binding]; other site 156889006807 ATP-binding site [chemical binding]; other site 156889006808 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 156889006809 AAA domain; Region: AAA_24; pfam13479 156889006810 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 156889006811 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 156889006812 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 156889006813 Catalytic site [active] 156889006814 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 156889006815 LexA repressor; Validated; Region: PRK00215 156889006816 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 156889006817 Catalytic site [active] 156889006818 TSCPD domain; Region: TSCPD; pfam12637 156889006819 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 156889006820 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 156889006821 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 156889006822 catalytic residues [active] 156889006823 catalytic nucleophile [active] 156889006824 Recombinase; Region: Recombinase; pfam07508 156889006825 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 156889006826 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 156889006827 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 156889006828 dimerization interface [polypeptide binding]; other site 156889006829 PBP superfamily domain; Region: PBP_like_2; cl17296 156889006830 PAS domain S-box; Region: sensory_box; TIGR00229 156889006831 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889006832 putative active site [active] 156889006833 heme pocket [chemical binding]; other site 156889006834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 156889006835 Histidine kinase; Region: HisKA_3; pfam07730 156889006836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889006837 ATP binding site [chemical binding]; other site 156889006838 Mg2+ binding site [ion binding]; other site 156889006839 G-X-G motif; other site 156889006840 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 156889006841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006842 active site 156889006843 phosphorylation site [posttranslational modification] 156889006844 intermolecular recognition site; other site 156889006845 dimerization interface [polypeptide binding]; other site 156889006846 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 156889006847 DNA binding residues [nucleotide binding] 156889006848 dimerization interface [polypeptide binding]; other site 156889006849 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889006850 anti sigma factor interaction site; other site 156889006851 regulatory phosphorylation site [posttranslational modification]; other site 156889006852 Bacitracin resistance protein BacA; Region: BacA; pfam02673 156889006853 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 156889006854 metal-binding site [ion binding] 156889006855 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 156889006856 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 156889006857 dimerization interface 3.5A [polypeptide binding]; other site 156889006858 active site 156889006859 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 156889006860 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 156889006861 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 156889006862 P-loop; other site 156889006863 Magnesium ion binding site [ion binding]; other site 156889006864 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 156889006865 Magnesium ion binding site [ion binding]; other site 156889006866 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 156889006867 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 156889006868 dimer interface [polypeptide binding]; other site 156889006869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889006870 catalytic residue [active] 156889006871 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 156889006872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889006873 Walker A/P-loop; other site 156889006874 ATP binding site [chemical binding]; other site 156889006875 Q-loop/lid; other site 156889006876 ABC transporter signature motif; other site 156889006877 Walker B; other site 156889006878 D-loop; other site 156889006879 H-loop/switch region; other site 156889006880 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 156889006881 LexA repressor; Validated; Region: PRK00215 156889006882 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 156889006883 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 156889006884 Catalytic site [active] 156889006885 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 156889006886 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 156889006887 active site 156889006888 DNA binding site [nucleotide binding] 156889006889 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 156889006890 4Fe-4S binding domain; Region: Fer4_5; pfam12801 156889006891 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 156889006892 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 156889006893 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 156889006894 Uncharacterized conserved protein [Function unknown]; Region: COG2006 156889006895 Domain of unknown function (DUF362); Region: DUF362; pfam04015 156889006896 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 156889006897 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 156889006898 active site 156889006899 catalytic tetrad [active] 156889006900 Cache domain; Region: Cache_1; pfam02743 156889006901 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 156889006902 GAF domain; Region: GAF; pfam01590 156889006903 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889006904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889006905 dimer interface [polypeptide binding]; other site 156889006906 phosphorylation site [posttranslational modification] 156889006907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889006908 ATP binding site [chemical binding]; other site 156889006909 Mg2+ binding site [ion binding]; other site 156889006910 G-X-G motif; other site 156889006911 Response regulator receiver domain; Region: Response_reg; pfam00072 156889006912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006913 active site 156889006914 phosphorylation site [posttranslational modification] 156889006915 intermolecular recognition site; other site 156889006916 dimerization interface [polypeptide binding]; other site 156889006917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006918 active site 156889006919 phosphorylation site [posttranslational modification] 156889006920 intermolecular recognition site; other site 156889006921 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889006922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006923 active site 156889006924 phosphorylation site [posttranslational modification] 156889006925 intermolecular recognition site; other site 156889006926 dimerization interface [polypeptide binding]; other site 156889006927 CheB methylesterase; Region: CheB_methylest; pfam01339 156889006928 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 156889006929 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 156889006930 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889006931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006932 active site 156889006933 phosphorylation site [posttranslational modification] 156889006934 intermolecular recognition site; other site 156889006935 dimerization interface [polypeptide binding]; other site 156889006936 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889006937 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889006938 putative active site [active] 156889006939 heme pocket [chemical binding]; other site 156889006940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889006941 dimer interface [polypeptide binding]; other site 156889006942 phosphorylation site [posttranslational modification] 156889006943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889006944 ATP binding site [chemical binding]; other site 156889006945 Mg2+ binding site [ion binding]; other site 156889006946 G-X-G motif; other site 156889006947 Response regulator receiver domain; Region: Response_reg; pfam00072 156889006948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889006949 active site 156889006950 phosphorylation site [posttranslational modification] 156889006951 intermolecular recognition site; other site 156889006952 dimerization interface [polypeptide binding]; other site 156889006953 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 156889006954 RNA/DNA hybrid binding site [nucleotide binding]; other site 156889006955 active site 156889006956 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 156889006957 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 156889006958 putative NAD(P) binding site [chemical binding]; other site 156889006959 active site 156889006960 putative substrate binding site [chemical binding]; other site 156889006961 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 156889006962 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 156889006963 Ligand binding site; other site 156889006964 oligomer interface; other site 156889006965 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 156889006966 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 156889006967 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889006968 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889006969 dimer interface [polypeptide binding]; other site 156889006970 putative CheW interface [polypeptide binding]; other site 156889006971 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 156889006972 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 156889006973 ligand binding site [chemical binding]; other site 156889006974 homodimer interface [polypeptide binding]; other site 156889006975 NAD(P) binding site [chemical binding]; other site 156889006976 trimer interface B [polypeptide binding]; other site 156889006977 trimer interface A [polypeptide binding]; other site 156889006978 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 156889006979 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 156889006980 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 156889006981 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889006982 IHF dimer interface [polypeptide binding]; other site 156889006983 IHF - DNA interface [nucleotide binding]; other site 156889006984 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 156889006985 AAA domain; Region: AAA_31; pfam13614 156889006986 P-loop; other site 156889006987 Magnesium ion binding site [ion binding]; other site 156889006988 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889006989 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 156889006990 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 156889006991 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 156889006992 NADP binding site [chemical binding]; other site 156889006993 active site 156889006994 putative substrate binding site [chemical binding]; other site 156889006995 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 156889006996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889006997 Walker A/P-loop; other site 156889006998 ATP binding site [chemical binding]; other site 156889006999 Q-loop/lid; other site 156889007000 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 156889007001 ABC transporter signature motif; other site 156889007002 Walker B; other site 156889007003 D-loop; other site 156889007004 ABC transporter; Region: ABC_tran_2; pfam12848 156889007005 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 156889007006 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 156889007007 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 156889007008 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 156889007009 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889007010 IHF dimer interface [polypeptide binding]; other site 156889007011 IHF - DNA interface [nucleotide binding]; other site 156889007012 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 156889007013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 156889007014 AMIN domain; Region: AMIN; pfam11741 156889007015 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 156889007016 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 156889007017 active site 156889007018 metal binding site [ion binding]; metal-binding site 156889007019 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 156889007020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889007021 S-adenosylmethionine binding site [chemical binding]; other site 156889007022 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 156889007023 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 156889007024 RNA binding surface [nucleotide binding]; other site 156889007025 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 156889007026 active site 156889007027 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 156889007028 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 156889007029 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 156889007030 DctM-like transporters; Region: DctM; pfam06808 156889007031 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 156889007032 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 156889007033 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 156889007034 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 156889007035 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 156889007036 dimer interface [polypeptide binding]; other site 156889007037 catalytic triad [active] 156889007038 peroxidatic and resolving cysteines [active] 156889007039 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 156889007040 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 156889007041 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 156889007042 GTP binding site; other site 156889007043 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 156889007044 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 156889007045 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 156889007046 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 156889007047 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 156889007048 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 156889007049 lipoprotein signal peptidase; Provisional; Region: PRK14787 156889007050 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 156889007051 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 156889007052 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 156889007053 active site 156889007054 HIGH motif; other site 156889007055 nucleotide binding site [chemical binding]; other site 156889007056 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 156889007057 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 156889007058 active site 156889007059 KMSKS motif; other site 156889007060 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 156889007061 tRNA binding surface [nucleotide binding]; other site 156889007062 anticodon binding site; other site 156889007063 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 156889007064 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 156889007065 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 156889007066 active site 156889007067 Riboflavin kinase; Region: Flavokinase; pfam01687 156889007068 periplasmic folding chaperone; Provisional; Region: PRK10788 156889007069 SurA N-terminal domain; Region: SurA_N_3; cl07813 156889007070 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 156889007071 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 156889007072 HAMP domain; Region: HAMP; pfam00672 156889007073 dimerization interface [polypeptide binding]; other site 156889007074 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889007075 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889007076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889007077 dimer interface [polypeptide binding]; other site 156889007078 putative CheW interface [polypeptide binding]; other site 156889007079 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 156889007080 putative ligand binding pocket/active site [active] 156889007081 putative metal binding site [ion binding]; other site 156889007082 AMMECR1; Region: AMMECR1; pfam01871 156889007083 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 156889007084 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 156889007085 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 156889007086 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 156889007087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 156889007088 dimer interface [polypeptide binding]; other site 156889007089 conserved gate region; other site 156889007090 putative PBP binding loops; other site 156889007091 ABC-ATPase subunit interface; other site 156889007092 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 156889007093 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 156889007094 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 156889007095 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 156889007096 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 156889007097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 156889007098 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 156889007099 Predicted integral membrane protein [Function unknown]; Region: COG5615 156889007100 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 156889007101 aromatic arch; other site 156889007102 DCoH dimer interaction site [polypeptide binding]; other site 156889007103 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 156889007104 DCoH tetramer interaction site [polypeptide binding]; other site 156889007105 substrate binding site [chemical binding]; other site 156889007106 TPR repeat; Region: TPR_11; pfam13414 156889007107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889007108 binding surface 156889007109 TPR motif; other site 156889007110 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889007111 Sporulation related domain; Region: SPOR; pfam05036 156889007112 Radical SAM superfamily; Region: Radical_SAM; pfam04055 156889007113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889007114 FeS/SAM binding site; other site 156889007115 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 156889007116 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 156889007117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 156889007118 binding surface 156889007119 TPR motif; other site 156889007120 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 156889007121 extended (e) SDRs; Region: SDR_e; cd08946 156889007122 NAD(P) binding site [chemical binding]; other site 156889007123 active site 156889007124 substrate binding site [chemical binding]; other site 156889007125 hypothetical protein; Provisional; Region: PRK05170 156889007126 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 156889007127 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 156889007128 active site 156889007129 Zn binding site [ion binding]; other site 156889007130 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 156889007131 nudix motif; other site 156889007132 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 156889007133 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 156889007134 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 156889007135 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 156889007136 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 156889007137 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889007138 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889007139 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 156889007140 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 156889007141 nucleotide binding region [chemical binding]; other site 156889007142 helicase superfamily c-terminal domain; Region: HELICc; smart00490 156889007143 ATP-binding site [chemical binding]; other site 156889007144 Sec8 exocyst complex component specific domain; Region: Sec8_exocyst; pfam04048 156889007145 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889007146 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889007147 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 156889007148 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 156889007149 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 156889007150 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007151 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007152 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 156889007153 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007154 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 156889007155 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 156889007156 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007157 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007158 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 156889007159 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007160 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 156889007161 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 156889007162 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007163 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007164 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007165 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 156889007166 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007167 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007168 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007169 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 156889007170 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 156889007171 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007172 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007173 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007174 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 156889007175 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007176 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007177 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007178 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 156889007179 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 156889007180 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007181 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007182 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 156889007183 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007184 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007185 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 156889007186 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007187 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 156889007188 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007189 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 156889007190 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 156889007191 VCBS repeat; Region: VCBS_repeat; TIGR01965 156889007192 VCBS repeat; Region: VCBS_repeat; TIGR01965 156889007193 VCBS repeat; Region: VCBS_repeat; TIGR01965 156889007194 VCBS repeat; Region: VCBS_repeat; TIGR01965 156889007195 VCBS repeat; Region: VCBS_repeat; TIGR01965 156889007196 AMIN domain; Region: AMIN; pfam11741 156889007197 AMIN domain; Region: AMIN; pfam11741 156889007198 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 156889007199 SapC; Region: SapC; pfam07277 156889007200 Domain of unknown function DUF77; Region: DUF77; pfam01910 156889007201 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889007202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889007203 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889007204 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889007205 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889007206 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889007207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889007208 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 156889007209 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889007210 anti sigma factor interaction site; other site 156889007211 regulatory phosphorylation site [posttranslational modification]; other site 156889007212 FeoA domain; Region: FeoA; pfam04023 156889007213 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889007214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889007215 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889007216 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889007217 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889007218 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889007219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889007220 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 156889007221 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 156889007222 Sulfate transporter family; Region: Sulfate_transp; pfam00916 156889007223 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 156889007224 pyruvate phosphate dikinase; Provisional; Region: PRK09279 156889007225 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 156889007226 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 156889007227 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 156889007228 translation initiation factor Sui1; Validated; Region: PRK06824 156889007229 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 156889007230 putative rRNA binding site [nucleotide binding]; other site 156889007231 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 156889007232 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 156889007233 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 156889007234 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 156889007235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889007236 nucleotide binding region [chemical binding]; other site 156889007237 ATP-binding site [chemical binding]; other site 156889007238 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 156889007239 active site 156889007240 putative substrate binding region [chemical binding]; other site 156889007241 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 156889007242 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889007243 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 156889007244 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 156889007245 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889007246 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889007247 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889007248 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 156889007249 SapC; Region: SapC; pfam07277 156889007250 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889007251 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 156889007252 diiron binding motif [ion binding]; other site 156889007253 putative oxidoreductase; Provisional; Region: PRK13984 156889007254 4Fe-4S binding domain; Region: Fer4; pfam00037 156889007255 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 156889007256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 156889007257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 156889007258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 156889007259 NADH dehydrogenase subunit D; Validated; Region: PRK06075 156889007260 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 156889007261 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 156889007262 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 156889007263 NADH dehydrogenase subunit B; Validated; Region: PRK06411 156889007264 NADH dehydrogenase; Region: NADHdh; cl00469 156889007265 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 156889007266 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 156889007267 NADH dehydrogenase subunit M; Validated; Region: PRK08668 156889007268 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 156889007269 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 156889007270 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 156889007271 hypothetical protein; Provisional; Region: PRK08378 156889007272 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 156889007273 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 156889007274 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 156889007275 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 156889007276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889007277 S-adenosylmethionine binding site [chemical binding]; other site 156889007278 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 156889007279 nucleoside/Zn binding site; other site 156889007280 dimer interface [polypeptide binding]; other site 156889007281 catalytic motif [active] 156889007282 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 156889007283 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889007284 dimerization interface [polypeptide binding]; other site 156889007285 PAS domain; Region: PAS_9; pfam13426 156889007286 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007287 putative active site [active] 156889007288 heme pocket [chemical binding]; other site 156889007289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007290 PAS domain; Region: PAS_9; pfam13426 156889007291 putative active site [active] 156889007292 heme pocket [chemical binding]; other site 156889007293 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889007294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889007295 metal binding site [ion binding]; metal-binding site 156889007296 active site 156889007297 I-site; other site 156889007298 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889007299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007300 PAS fold; Region: PAS_3; pfam08447 156889007301 putative active site [active] 156889007302 heme pocket [chemical binding]; other site 156889007303 PAS domain; Region: PAS_9; pfam13426 156889007304 PAS domain S-box; Region: sensory_box; TIGR00229 156889007305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007306 putative active site [active] 156889007307 heme pocket [chemical binding]; other site 156889007308 PAS domain S-box; Region: sensory_box; TIGR00229 156889007309 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007310 putative active site [active] 156889007311 heme pocket [chemical binding]; other site 156889007312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889007313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889007314 dimer interface [polypeptide binding]; other site 156889007315 phosphorylation site [posttranslational modification] 156889007316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007317 ATP binding site [chemical binding]; other site 156889007318 Mg2+ binding site [ion binding]; other site 156889007319 G-X-G motif; other site 156889007320 Response regulator receiver domain; Region: Response_reg; pfam00072 156889007321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007322 active site 156889007323 phosphorylation site [posttranslational modification] 156889007324 intermolecular recognition site; other site 156889007325 dimerization interface [polypeptide binding]; other site 156889007326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889007327 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 156889007328 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 156889007329 active site 156889007330 metal binding site [ion binding]; metal-binding site 156889007331 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 156889007332 active site 156889007333 SAM binding site [chemical binding]; other site 156889007334 homodimer interface [polypeptide binding]; other site 156889007335 CHASE3 domain; Region: CHASE3; cl05000 156889007336 GAF domain; Region: GAF; pfam01590 156889007337 GAF domain; Region: GAF_2; pfam13185 156889007338 PAS fold; Region: PAS_3; pfam08447 156889007339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007340 PAS domain; Region: PAS_9; pfam13426 156889007341 putative active site [active] 156889007342 heme pocket [chemical binding]; other site 156889007343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889007344 metal binding site [ion binding]; metal-binding site 156889007345 active site 156889007346 I-site; other site 156889007347 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889007348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 156889007349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 156889007350 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 156889007351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007352 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 156889007353 putative active site [active] 156889007354 heme pocket [chemical binding]; other site 156889007355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889007356 dimer interface [polypeptide binding]; other site 156889007357 phosphorylation site [posttranslational modification] 156889007358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007359 ATP binding site [chemical binding]; other site 156889007360 Mg2+ binding site [ion binding]; other site 156889007361 G-X-G motif; other site 156889007362 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889007363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007364 active site 156889007365 phosphorylation site [posttranslational modification] 156889007366 intermolecular recognition site; other site 156889007367 dimerization interface [polypeptide binding]; other site 156889007368 Integrase core domain; Region: rve; pfam00665 156889007369 Integrase core domain; Region: rve_3; pfam13683 156889007370 Hemerythrin; Region: Hemerythrin; cd12107 156889007371 Fe binding site [ion binding]; other site 156889007372 TPR repeat; Region: TPR_11; pfam13414 156889007373 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889007374 binding surface 156889007375 TPR motif; other site 156889007376 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889007377 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 156889007378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 156889007379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 156889007380 putative substrate translocation pore; other site 156889007381 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 156889007382 PilZ domain; Region: PilZ; pfam07238 156889007383 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 156889007384 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 156889007385 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 156889007386 LemA family; Region: LemA; cl00742 156889007387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889007388 binding surface 156889007389 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889007390 TPR motif; other site 156889007391 TPR repeat; Region: TPR_11; pfam13414 156889007392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889007393 binding surface 156889007394 TPR motif; other site 156889007395 TPR repeat; Region: TPR_11; pfam13414 156889007396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889007397 TPR motif; other site 156889007398 binding surface 156889007399 TPR repeat; Region: TPR_11; pfam13414 156889007400 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 156889007401 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 156889007402 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 156889007403 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 156889007404 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 156889007405 Cation efflux family; Region: Cation_efflux; pfam01545 156889007406 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 156889007407 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 156889007408 nucleotide binding site [chemical binding]; other site 156889007409 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 156889007410 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889007411 Zn2+ binding site [ion binding]; other site 156889007412 Mg2+ binding site [ion binding]; other site 156889007413 Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968 156889007414 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 156889007415 diiron binding motif [ion binding]; other site 156889007416 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 156889007417 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 156889007418 protein binding site [polypeptide binding]; other site 156889007419 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 156889007420 protein binding site [polypeptide binding]; other site 156889007421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 156889007422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 156889007423 putative substrate translocation pore; other site 156889007424 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889007425 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 156889007426 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 156889007427 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889007428 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889007429 ligand binding site [chemical binding]; other site 156889007430 flexible hinge region; other site 156889007431 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 156889007432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889007433 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 156889007434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007435 ATP binding site [chemical binding]; other site 156889007436 Mg2+ binding site [ion binding]; other site 156889007437 G-X-G motif; other site 156889007438 Transposase; Region: HTH_Tnp_1; cl17663 156889007439 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 156889007440 active site residue [active] 156889007441 SdiA-regulated; Region: SdiA-regulated; cd09971 156889007442 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 156889007443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007444 PAS fold; Region: PAS_4; pfam08448 156889007445 putative active site [active] 156889007446 heme pocket [chemical binding]; other site 156889007447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889007448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889007449 dimer interface [polypeptide binding]; other site 156889007450 phosphorylation site [posttranslational modification] 156889007451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007452 ATP binding site [chemical binding]; other site 156889007453 Mg2+ binding site [ion binding]; other site 156889007454 G-X-G motif; other site 156889007455 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889007456 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889007457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007458 active site 156889007459 phosphorylation site [posttranslational modification] 156889007460 intermolecular recognition site; other site 156889007461 dimerization interface [polypeptide binding]; other site 156889007462 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 156889007463 Chemotaxis phosphatase CheX; Region: CheX; cl15816 156889007464 Response regulator receiver domain; Region: Response_reg; pfam00072 156889007465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007466 active site 156889007467 phosphorylation site [posttranslational modification] 156889007468 intermolecular recognition site; other site 156889007469 dimerization interface [polypeptide binding]; other site 156889007470 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889007471 putative binding surface; other site 156889007472 active site 156889007473 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 156889007474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007475 ATP binding site [chemical binding]; other site 156889007476 Mg2+ binding site [ion binding]; other site 156889007477 G-X-G motif; other site 156889007478 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 156889007479 ABC-2 type transporter; Region: ABC2_membrane; cl17235 156889007480 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 156889007481 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 156889007482 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 156889007483 Walker A/P-loop; other site 156889007484 ATP binding site [chemical binding]; other site 156889007485 Q-loop/lid; other site 156889007486 ABC transporter signature motif; other site 156889007487 Walker B; other site 156889007488 D-loop; other site 156889007489 H-loop/switch region; other site 156889007490 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 156889007491 BED zinc finger; Region: zf-BED; cl02703 156889007492 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 156889007493 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 156889007494 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 156889007495 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 156889007496 putative catalytic site [active] 156889007497 putative metal binding site [ion binding]; other site 156889007498 putative phosphate binding site [ion binding]; other site 156889007499 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889007500 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 156889007501 methionine sulfoxide reductase A; Provisional; Region: PRK00058 156889007502 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889007503 Sel1 repeat; Region: Sel1; cl02723 156889007504 Sel1-like repeats; Region: SEL1; smart00671 156889007505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889007506 Response regulator receiver domain; Region: Response_reg; pfam00072 156889007507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007508 active site 156889007509 phosphorylation site [posttranslational modification] 156889007510 intermolecular recognition site; other site 156889007511 dimerization interface [polypeptide binding]; other site 156889007512 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 156889007513 dimer interface [polypeptide binding]; other site 156889007514 active site 156889007515 YibE/F-like protein; Region: YibE_F; pfam07907 156889007516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889007517 sequence-specific DNA binding site [nucleotide binding]; other site 156889007518 salt bridge; other site 156889007519 Response regulator receiver domain; Region: Response_reg; pfam00072 156889007520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007521 active site 156889007522 phosphorylation site [posttranslational modification] 156889007523 intermolecular recognition site; other site 156889007524 dimerization interface [polypeptide binding]; other site 156889007525 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 156889007526 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 156889007527 P-loop, Walker A motif; other site 156889007528 Base recognition motif; other site 156889007529 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 156889007530 Hpt domain; Region: Hpt; pfam01627 156889007531 putative binding surface; other site 156889007532 active site 156889007533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007534 active site 156889007535 phosphorylation site [posttranslational modification] 156889007536 intermolecular recognition site; other site 156889007537 dimerization interface [polypeptide binding]; other site 156889007538 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889007539 putative binding surface; other site 156889007540 active site 156889007541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889007542 dimer interface [polypeptide binding]; other site 156889007543 phosphorylation site [posttranslational modification] 156889007544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007545 ATP binding site [chemical binding]; other site 156889007546 Mg2+ binding site [ion binding]; other site 156889007547 G-X-G motif; other site 156889007548 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 156889007549 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889007550 substrate binding pocket [chemical binding]; other site 156889007551 membrane-bound complex binding site; other site 156889007552 hinge residues; other site 156889007553 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 156889007554 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 156889007555 putative trimer interface [polypeptide binding]; other site 156889007556 putative CoA binding site [chemical binding]; other site 156889007557 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 156889007558 dimer interface [polypeptide binding]; other site 156889007559 active site 156889007560 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 156889007561 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 156889007562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 156889007563 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 156889007564 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 156889007565 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 156889007566 dimerization interface [polypeptide binding]; other site 156889007567 putative ATP binding site [chemical binding]; other site 156889007568 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 156889007569 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 156889007570 active site 156889007571 substrate binding site [chemical binding]; other site 156889007572 cosubstrate binding site; other site 156889007573 catalytic site [active] 156889007574 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 156889007575 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 156889007576 active site 156889007577 dimer interface [polypeptide binding]; other site 156889007578 metal binding site [ion binding]; metal-binding site 156889007579 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 156889007580 Transglycosylase; Region: Transgly; pfam00912 156889007581 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 156889007582 NnrS protein; Region: NnrS; pfam05940 156889007583 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 156889007584 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 156889007585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 156889007586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 156889007587 DNA binding residues [nucleotide binding] 156889007588 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 156889007589 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 156889007590 putative acyl-acceptor binding pocket; other site 156889007591 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 156889007592 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 156889007593 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 156889007594 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 156889007595 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 156889007596 SurA N-terminal domain; Region: SurA_N; pfam09312 156889007597 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 156889007598 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 156889007599 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 156889007600 Organic solvent tolerance protein; Region: OstA_C; pfam04453 156889007601 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 156889007602 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 156889007603 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 156889007604 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 156889007605 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 156889007606 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 156889007607 active site 156889007608 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 156889007609 active site 156889007610 ribulose/triose binding site [chemical binding]; other site 156889007611 phosphate binding site [ion binding]; other site 156889007612 substrate (anthranilate) binding pocket [chemical binding]; other site 156889007613 product (indole) binding pocket [chemical binding]; other site 156889007614 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 156889007615 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 156889007616 active site 156889007617 HIGH motif; other site 156889007618 dimer interface [polypeptide binding]; other site 156889007619 KMSKS motif; other site 156889007620 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 156889007621 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 156889007622 methionine sulfoxide reductase B; Provisional; Region: PRK00222 156889007623 SelR domain; Region: SelR; pfam01641 156889007624 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 156889007625 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889007626 putative CheW interface [polypeptide binding]; other site 156889007627 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889007628 active site 156889007629 I-site; other site 156889007630 metal binding site [ion binding]; metal-binding site 156889007631 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 156889007632 dimer interface [polypeptide binding]; other site 156889007633 [2Fe-2S] cluster binding site [ion binding]; other site 156889007634 Response regulator receiver domain; Region: Response_reg; pfam00072 156889007635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007636 active site 156889007637 phosphorylation site [posttranslational modification] 156889007638 intermolecular recognition site; other site 156889007639 dimerization interface [polypeptide binding]; other site 156889007640 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 156889007641 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 156889007642 osmolarity response regulator; Provisional; Region: ompR; PRK09468 156889007643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007644 active site 156889007645 phosphorylation site [posttranslational modification] 156889007646 intermolecular recognition site; other site 156889007647 dimerization interface [polypeptide binding]; other site 156889007648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 156889007649 DNA binding site [nucleotide binding] 156889007650 HAMP domain; Region: HAMP; pfam00672 156889007651 dimerization interface [polypeptide binding]; other site 156889007652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889007653 dimer interface [polypeptide binding]; other site 156889007654 phosphorylation site [posttranslational modification] 156889007655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007656 ATP binding site [chemical binding]; other site 156889007657 Mg2+ binding site [ion binding]; other site 156889007658 G-X-G motif; other site 156889007659 FixH; Region: FixH; pfam05751 156889007660 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 156889007661 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 156889007662 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 156889007663 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 156889007664 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 156889007665 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 156889007666 Low-spin heme binding site [chemical binding]; other site 156889007667 Putative water exit pathway; other site 156889007668 Binuclear center (active site) [active] 156889007669 Putative proton exit pathway; other site 156889007670 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 156889007671 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 156889007672 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 156889007673 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 156889007674 Cytochrome c; Region: Cytochrom_C; pfam00034 156889007675 Ion channel; Region: Ion_trans_2; pfam07885 156889007676 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 156889007677 TrkA-N domain; Region: TrkA_N; pfam02254 156889007678 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 156889007679 TrkA-N domain; Region: TrkA_N; pfam02254 156889007680 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 156889007681 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 156889007682 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 156889007683 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 156889007684 metal-binding site [ion binding] 156889007685 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 156889007686 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889007687 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 156889007688 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 156889007689 catalytic residues [active] 156889007690 HAMP domain; Region: HAMP; pfam00672 156889007691 dimerization interface [polypeptide binding]; other site 156889007692 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889007693 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889007694 dimer interface [polypeptide binding]; other site 156889007695 putative CheW interface [polypeptide binding]; other site 156889007696 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 156889007697 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 156889007698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889007699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889007700 metal binding site [ion binding]; metal-binding site 156889007701 active site 156889007702 I-site; other site 156889007703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889007704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889007705 dimerization interface [polypeptide binding]; other site 156889007706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889007707 dimer interface [polypeptide binding]; other site 156889007708 phosphorylation site [posttranslational modification] 156889007709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007710 ATP binding site [chemical binding]; other site 156889007711 Mg2+ binding site [ion binding]; other site 156889007712 G-X-G motif; other site 156889007713 Response regulator receiver domain; Region: Response_reg; pfam00072 156889007714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007715 active site 156889007716 phosphorylation site [posttranslational modification] 156889007717 intermolecular recognition site; other site 156889007718 dimerization interface [polypeptide binding]; other site 156889007719 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 156889007720 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 156889007721 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 156889007722 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889007723 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889007724 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 156889007725 homotrimer interface [polypeptide binding]; other site 156889007726 Walker A motif; other site 156889007727 GTP binding site [chemical binding]; other site 156889007728 Walker B motif; other site 156889007729 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 156889007730 EamA-like transporter family; Region: EamA; pfam00892 156889007731 EamA-like transporter family; Region: EamA; cl17759 156889007732 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 156889007733 Uncharacterized conserved protein [Function unknown]; Region: COG4121 156889007734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 156889007735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889007736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007737 ATP binding site [chemical binding]; other site 156889007738 Mg2+ binding site [ion binding]; other site 156889007739 G-X-G motif; other site 156889007740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007741 PAS fold; Region: PAS_3; pfam08447 156889007742 putative active site [active] 156889007743 heme pocket [chemical binding]; other site 156889007744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007745 PAS domain; Region: PAS_9; pfam13426 156889007746 putative active site [active] 156889007747 heme pocket [chemical binding]; other site 156889007748 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889007749 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889007750 metal binding site [ion binding]; metal-binding site 156889007751 active site 156889007752 I-site; other site 156889007753 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889007754 Transcriptional regulator [Transcription]; Region: LysR; COG0583 156889007755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 156889007756 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 156889007757 dimerization interface [polypeptide binding]; other site 156889007758 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 156889007759 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 156889007760 putative ligand binding site [chemical binding]; other site 156889007761 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 156889007762 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007763 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889007764 putative active site [active] 156889007765 heme pocket [chemical binding]; other site 156889007766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007767 putative active site [active] 156889007768 heme pocket [chemical binding]; other site 156889007769 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889007770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007771 putative active site [active] 156889007772 heme pocket [chemical binding]; other site 156889007773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889007774 dimer interface [polypeptide binding]; other site 156889007775 phosphorylation site [posttranslational modification] 156889007776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007777 ATP binding site [chemical binding]; other site 156889007778 Mg2+ binding site [ion binding]; other site 156889007779 G-X-G motif; other site 156889007780 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889007781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007782 active site 156889007783 phosphorylation site [posttranslational modification] 156889007784 intermolecular recognition site; other site 156889007785 dimerization interface [polypeptide binding]; other site 156889007786 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 156889007787 selenophosphate synthetase; Provisional; Region: PRK00943 156889007788 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 156889007789 dimerization interface [polypeptide binding]; other site 156889007790 putative ATP binding site [chemical binding]; other site 156889007791 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 156889007792 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 156889007793 active site residue [active] 156889007794 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 156889007795 putative active site pocket [active] 156889007796 dimerization interface [polypeptide binding]; other site 156889007797 putative catalytic residue [active] 156889007798 PAS domain S-box; Region: sensory_box; TIGR00229 156889007799 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889007800 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889007801 metal binding site [ion binding]; metal-binding site 156889007802 active site 156889007803 I-site; other site 156889007804 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889007805 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 156889007806 HAMP domain; Region: HAMP; pfam00672 156889007807 dimerization interface [polypeptide binding]; other site 156889007808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889007809 dimer interface [polypeptide binding]; other site 156889007810 putative CheW interface [polypeptide binding]; other site 156889007811 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 156889007812 HAMP domain; Region: HAMP; pfam00672 156889007813 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889007814 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889007815 dimer interface [polypeptide binding]; other site 156889007816 putative CheW interface [polypeptide binding]; other site 156889007817 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889007818 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889007819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007820 active site 156889007821 phosphorylation site [posttranslational modification] 156889007822 intermolecular recognition site; other site 156889007823 dimerization interface [polypeptide binding]; other site 156889007824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889007825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889007826 dimer interface [polypeptide binding]; other site 156889007827 phosphorylation site [posttranslational modification] 156889007828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007829 ATP binding site [chemical binding]; other site 156889007830 Mg2+ binding site [ion binding]; other site 156889007831 G-X-G motif; other site 156889007832 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889007833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007834 active site 156889007835 phosphorylation site [posttranslational modification] 156889007836 intermolecular recognition site; other site 156889007837 dimerization interface [polypeptide binding]; other site 156889007838 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889007839 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889007840 substrate binding pocket [chemical binding]; other site 156889007841 membrane-bound complex binding site; other site 156889007842 hinge residues; other site 156889007843 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889007844 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889007845 substrate binding pocket [chemical binding]; other site 156889007846 membrane-bound complex binding site; other site 156889007847 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889007848 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889007849 substrate binding pocket [chemical binding]; other site 156889007850 membrane-bound complex binding site; other site 156889007851 hinge residues; other site 156889007852 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889007853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889007854 putative active site [active] 156889007855 heme pocket [chemical binding]; other site 156889007856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889007857 dimer interface [polypeptide binding]; other site 156889007858 phosphorylation site [posttranslational modification] 156889007859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889007860 ATP binding site [chemical binding]; other site 156889007861 Mg2+ binding site [ion binding]; other site 156889007862 G-X-G motif; other site 156889007863 Response regulator receiver domain; Region: Response_reg; pfam00072 156889007864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007865 active site 156889007866 phosphorylation site [posttranslational modification] 156889007867 intermolecular recognition site; other site 156889007868 dimerization interface [polypeptide binding]; other site 156889007869 Response regulator receiver domain; Region: Response_reg; pfam00072 156889007870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889007871 active site 156889007872 phosphorylation site [posttranslational modification] 156889007873 intermolecular recognition site; other site 156889007874 dimerization interface [polypeptide binding]; other site 156889007875 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889007876 putative binding surface; other site 156889007877 active site 156889007878 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 156889007879 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 156889007880 TPP-binding site [chemical binding]; other site 156889007881 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 156889007882 dimer interface [polypeptide binding]; other site 156889007883 PYR/PP interface [polypeptide binding]; other site 156889007884 TPP binding site [chemical binding]; other site 156889007885 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 156889007886 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 156889007887 E3 interaction surface; other site 156889007888 lipoyl attachment site [posttranslational modification]; other site 156889007889 e3 binding domain; Region: E3_binding; pfam02817 156889007890 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 156889007891 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 156889007892 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 156889007893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 156889007894 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 156889007895 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 156889007896 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 156889007897 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 156889007898 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 156889007899 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 156889007900 phosphodiesterase YaeI; Provisional; Region: PRK11340 156889007901 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 156889007902 putative active site [active] 156889007903 putative metal binding site [ion binding]; other site 156889007904 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 156889007905 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 156889007906 HAMP domain; Region: HAMP; pfam00672 156889007907 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889007908 dimer interface [polypeptide binding]; other site 156889007909 putative CheW interface [polypeptide binding]; other site 156889007910 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 156889007911 putative glycosyl transferase; Provisional; Region: PRK10307 156889007912 O-Antigen ligase; Region: Wzy_C; pfam04932 156889007913 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 156889007914 Chain length determinant protein; Region: Wzz; pfam02706 156889007915 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 156889007916 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 156889007917 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 156889007918 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 156889007919 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 156889007920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 156889007921 motif II; other site 156889007922 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 156889007923 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 156889007924 AMMECR1; Region: AMMECR1; cl00911 156889007925 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 156889007926 NeuB family; Region: NeuB; pfam03102 156889007927 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 156889007928 NeuB binding interface [polypeptide binding]; other site 156889007929 putative substrate binding site [chemical binding]; other site 156889007930 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 156889007931 nudix motif; other site 156889007932 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 156889007933 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 156889007934 NAD(P) binding site [chemical binding]; other site 156889007935 homodimer interface [polypeptide binding]; other site 156889007936 substrate binding site [chemical binding]; other site 156889007937 active site 156889007938 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 156889007939 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 156889007940 inhibitor-cofactor binding pocket; inhibition site 156889007941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889007942 catalytic residue [active] 156889007943 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 156889007944 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 156889007945 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 156889007946 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 156889007947 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 156889007948 ligand binding site; other site 156889007949 tetramer interface; other site 156889007950 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 156889007951 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 156889007952 putative active site [active] 156889007953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889007954 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 156889007955 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 156889007956 catalytic triad [active] 156889007957 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 156889007958 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 156889007959 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 156889007960 Walker A/P-loop; other site 156889007961 ATP binding site [chemical binding]; other site 156889007962 Q-loop/lid; other site 156889007963 ABC transporter signature motif; other site 156889007964 Walker B; other site 156889007965 D-loop; other site 156889007966 H-loop/switch region; other site 156889007967 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 156889007968 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889007969 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 156889007970 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 156889007971 substrate binding site [chemical binding]; other site 156889007972 glutamase interaction surface [polypeptide binding]; other site 156889007973 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 156889007974 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 156889007975 inhibitor-cofactor binding pocket; inhibition site 156889007976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889007977 catalytic residue [active] 156889007978 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 156889007979 putative trimer interface [polypeptide binding]; other site 156889007980 putative active site [active] 156889007981 putative substrate binding site [chemical binding]; other site 156889007982 putative CoA binding site [chemical binding]; other site 156889007983 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 156889007984 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 156889007985 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 156889007986 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 156889007987 Ligand Binding Site [chemical binding]; other site 156889007988 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 156889007989 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 156889007990 Walker A/P-loop; other site 156889007991 ATP binding site [chemical binding]; other site 156889007992 Q-loop/lid; other site 156889007993 ABC transporter signature motif; other site 156889007994 Walker B; other site 156889007995 D-loop; other site 156889007996 H-loop/switch region; other site 156889007997 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 156889007998 putative carbohydrate binding site [chemical binding]; other site 156889007999 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 156889008000 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 156889008001 putative active site [active] 156889008002 oxyanion strand; other site 156889008003 catalytic triad [active] 156889008004 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 156889008005 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 156889008006 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889008007 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 156889008008 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889008009 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 156889008010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 156889008011 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 156889008012 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 156889008013 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 156889008014 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889008015 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 156889008016 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 156889008017 NADP-binding site; other site 156889008018 homotetramer interface [polypeptide binding]; other site 156889008019 substrate binding site [chemical binding]; other site 156889008020 homodimer interface [polypeptide binding]; other site 156889008021 active site 156889008022 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 156889008023 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 156889008024 phosphate binding site [ion binding]; other site 156889008025 putative substrate binding pocket [chemical binding]; other site 156889008026 dimer interface [polypeptide binding]; other site 156889008027 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 156889008028 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 156889008029 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 156889008030 PhoU domain; Region: PhoU; pfam01895 156889008031 PhoU domain; Region: PhoU; pfam01895 156889008032 HI0933-like protein; Region: HI0933_like; pfam03486 156889008033 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 156889008034 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889008035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008036 active site 156889008037 phosphorylation site [posttranslational modification] 156889008038 intermolecular recognition site; other site 156889008039 dimerization interface [polypeptide binding]; other site 156889008040 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 156889008041 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 156889008042 nucleotide binding site/active site [active] 156889008043 HIT family signature motif; other site 156889008044 catalytic residue [active] 156889008045 Response regulator receiver domain; Region: Response_reg; pfam00072 156889008046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008047 active site 156889008048 phosphorylation site [posttranslational modification] 156889008049 intermolecular recognition site; other site 156889008050 dimerization interface [polypeptide binding]; other site 156889008051 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 156889008052 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 156889008053 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 156889008054 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 156889008055 active site 156889008056 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 156889008057 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 156889008058 active site 156889008059 Substrate binding site; other site 156889008060 Mg++ binding site; other site 156889008061 phosphopentomutase; Provisional; Region: PRK05362 156889008062 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 156889008063 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 156889008064 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 156889008065 active site 156889008066 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 156889008067 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 156889008068 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 156889008069 inhibitor-cofactor binding pocket; inhibition site 156889008070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889008071 catalytic residue [active] 156889008072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 156889008073 PAS fold; Region: PAS_3; pfam08447 156889008074 putative active site [active] 156889008075 heme pocket [chemical binding]; other site 156889008076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889008077 PAS domain; Region: PAS_9; pfam13426 156889008078 putative active site [active] 156889008079 heme pocket [chemical binding]; other site 156889008080 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889008081 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889008082 metal binding site [ion binding]; metal-binding site 156889008083 active site 156889008084 I-site; other site 156889008085 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889008086 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 156889008087 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 156889008088 ligand binding site [chemical binding]; other site 156889008089 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889008090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889008091 PAS fold; Region: PAS_3; pfam08447 156889008092 putative active site [active] 156889008093 heme pocket [chemical binding]; other site 156889008094 PAS fold; Region: PAS_3; pfam08447 156889008095 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 156889008096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889008097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889008098 dimer interface [polypeptide binding]; other site 156889008099 phosphorylation site [posttranslational modification] 156889008100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889008101 ATP binding site [chemical binding]; other site 156889008102 Mg2+ binding site [ion binding]; other site 156889008103 G-X-G motif; other site 156889008104 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889008105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008106 active site 156889008107 phosphorylation site [posttranslational modification] 156889008108 intermolecular recognition site; other site 156889008109 dimerization interface [polypeptide binding]; other site 156889008110 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 156889008111 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889008112 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889008113 ligand binding site [chemical binding]; other site 156889008114 flexible hinge region; other site 156889008115 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889008116 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889008117 ligand binding site [chemical binding]; other site 156889008118 flexible hinge region; other site 156889008119 Hemerythrin; Region: Hemerythrin; cd12107 156889008120 Fe binding site [ion binding]; other site 156889008121 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 156889008122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008123 active site 156889008124 phosphorylation site [posttranslational modification] 156889008125 intermolecular recognition site; other site 156889008126 dimerization interface [polypeptide binding]; other site 156889008127 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889008128 Zn2+ binding site [ion binding]; other site 156889008129 Mg2+ binding site [ion binding]; other site 156889008130 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 156889008131 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 156889008132 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 156889008133 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889008134 putative active site [active] 156889008135 heme pocket [chemical binding]; other site 156889008136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889008137 dimer interface [polypeptide binding]; other site 156889008138 phosphorylation site [posttranslational modification] 156889008139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889008140 ATP binding site [chemical binding]; other site 156889008141 Mg2+ binding site [ion binding]; other site 156889008142 G-X-G motif; other site 156889008143 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889008144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008145 active site 156889008146 phosphorylation site [posttranslational modification] 156889008147 intermolecular recognition site; other site 156889008148 dimerization interface [polypeptide binding]; other site 156889008149 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889008150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008151 active site 156889008152 phosphorylation site [posttranslational modification] 156889008153 intermolecular recognition site; other site 156889008154 dimerization interface [polypeptide binding]; other site 156889008155 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 156889008156 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 156889008157 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 156889008158 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 156889008159 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 156889008160 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 156889008161 dimer interface [polypeptide binding]; other site 156889008162 ssDNA binding site [nucleotide binding]; other site 156889008163 tetramer (dimer of dimers) interface [polypeptide binding]; other site 156889008164 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 156889008165 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 156889008166 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 156889008167 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 156889008168 N-acetyl-D-glucosamine binding site [chemical binding]; other site 156889008169 catalytic residue [active] 156889008170 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 156889008171 putative active site [active] 156889008172 putative CoA binding site [chemical binding]; other site 156889008173 nudix motif; other site 156889008174 metal binding site [ion binding]; metal-binding site 156889008175 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 156889008176 putative catalytic site [active] 156889008177 putative phosphate binding site [ion binding]; other site 156889008178 active site 156889008179 metal binding site A [ion binding]; metal-binding site 156889008180 DNA binding site [nucleotide binding] 156889008181 putative AP binding site [nucleotide binding]; other site 156889008182 putative metal binding site B [ion binding]; other site 156889008183 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 156889008184 HD domain; Region: HD_4; pfam13328 156889008185 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 156889008186 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 156889008187 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889008188 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 156889008189 Predicted aspartyl protease [General function prediction only]; Region: COG3577 156889008190 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 156889008191 catalytic motif [active] 156889008192 Catalytic residue [active] 156889008193 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 156889008194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 156889008195 CreA protein; Region: CreA; pfam05981 156889008196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889008197 S-adenosylmethionine binding site [chemical binding]; other site 156889008198 Methyltransferase domain; Region: Methyltransf_23; pfam13489 156889008199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008200 active site 156889008201 phosphorylation site [posttranslational modification] 156889008202 intermolecular recognition site; other site 156889008203 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889008204 metal binding site [ion binding]; metal-binding site 156889008205 active site 156889008206 I-site; other site 156889008207 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889008208 Uncharacterized conserved protein [Function unknown]; Region: COG3287 156889008209 FIST N domain; Region: FIST; pfam08495 156889008210 FIST C domain; Region: FIST_C; pfam10442 156889008211 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889008212 putative active site [active] 156889008213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889008214 heme pocket [chemical binding]; other site 156889008215 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 156889008216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 156889008217 ATP binding site [chemical binding]; other site 156889008218 Mg2+ binding site [ion binding]; other site 156889008219 G-X-G motif; other site 156889008220 Response regulator receiver domain; Region: Response_reg; pfam00072 156889008221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008222 active site 156889008223 phosphorylation site [posttranslational modification] 156889008224 intermolecular recognition site; other site 156889008225 dimerization interface [polypeptide binding]; other site 156889008226 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 156889008227 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 156889008228 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 156889008229 putative acyl-acceptor binding pocket; other site 156889008230 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 156889008231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 156889008232 Family of unknown function (DUF490); Region: DUF490; pfam04357 156889008233 Family of unknown function (DUF490); Region: DUF490; pfam04357 156889008234 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 156889008235 Surface antigen; Region: Bac_surface_Ag; pfam01103 156889008236 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 156889008237 TMAO/DMSO reductase; Reviewed; Region: PRK05363 156889008238 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 156889008239 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 156889008240 Moco binding site; other site 156889008241 metal coordination site [ion binding]; other site 156889008242 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 156889008243 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 156889008244 dimerization interface [polypeptide binding]; other site 156889008245 ATP binding site [chemical binding]; other site 156889008246 Hydrogenase formation hypA family; Region: HypD; pfam01924 156889008247 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 156889008248 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 156889008249 Switch II region; other site 156889008250 G4 box; other site 156889008251 G5 box; other site 156889008252 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 156889008253 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 156889008254 HupF/HypC family; Region: HupF_HypC; pfam01455 156889008255 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 156889008256 active site clefts [active] 156889008257 zinc binding site [ion binding]; other site 156889008258 dimer interface [polypeptide binding]; other site 156889008259 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 156889008260 HAMP domain; Region: HAMP; pfam00672 156889008261 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889008262 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889008263 dimer interface [polypeptide binding]; other site 156889008264 putative CheW interface [polypeptide binding]; other site 156889008265 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889008266 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 156889008267 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 156889008268 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 156889008269 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 156889008270 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 156889008271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889008272 putative active site [active] 156889008273 heme pocket [chemical binding]; other site 156889008274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 156889008275 dimer interface [polypeptide binding]; other site 156889008276 phosphorylation site [posttranslational modification] 156889008277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889008278 ATP binding site [chemical binding]; other site 156889008279 Mg2+ binding site [ion binding]; other site 156889008280 G-X-G motif; other site 156889008281 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 156889008282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008283 active site 156889008284 phosphorylation site [posttranslational modification] 156889008285 intermolecular recognition site; other site 156889008286 dimerization interface [polypeptide binding]; other site 156889008287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889008288 Walker A motif; other site 156889008289 ATP binding site [chemical binding]; other site 156889008290 Walker B motif; other site 156889008291 arginine finger; other site 156889008292 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 156889008293 hydrogenase 1 large subunit; Provisional; Region: PRK10170 156889008294 Protein of unknown function (DUF3457); Region: DUF3457; pfam11939 156889008295 Flagellin N-methylase; Region: FliB; cl00497 156889008296 HupF/HypC family; Region: HupF_HypC; pfam01455 156889008297 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 156889008298 putative substrate-binding site; other site 156889008299 nickel binding site [ion binding]; other site 156889008300 hydrogenase 2 large subunit; Provisional; Region: PRK10467 156889008301 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 156889008302 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 156889008303 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 156889008304 4Fe-4S binding domain; Region: Fer4_6; pfam12837 156889008305 hydrogenase 2 small subunit; Provisional; Region: PRK10468 156889008306 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 156889008307 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 156889008308 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889008309 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 156889008310 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 156889008311 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889008312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 156889008313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 156889008314 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 156889008315 Predicted membrane protein [Function unknown]; Region: COG2119 156889008316 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 156889008317 Methyltransferase domain; Region: Methyltransf_23; pfam13489 156889008318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889008319 S-adenosylmethionine binding site [chemical binding]; other site 156889008320 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 156889008321 active site residue [active] 156889008322 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 156889008323 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 156889008324 active site residue [active] 156889008325 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 156889008326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 156889008327 Putative esterase; Region: Esterase; pfam00756 156889008328 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 156889008329 serine/threonine protein kinase; Provisional; Region: PRK11768 156889008330 Uncharacterized conserved protein [Function unknown]; Region: COG0397 156889008331 hypothetical protein; Validated; Region: PRK00029 156889008332 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 156889008333 Predicted membrane protein (DUF2107); Region: DUF2107; cl01658 156889008334 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 156889008335 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889008336 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889008337 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 156889008338 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889008339 Zn2+ binding site [ion binding]; other site 156889008340 Mg2+ binding site [ion binding]; other site 156889008341 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 156889008342 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889008343 Zn2+ binding site [ion binding]; other site 156889008344 Mg2+ binding site [ion binding]; other site 156889008345 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 156889008346 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889008347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008348 active site 156889008349 phosphorylation site [posttranslational modification] 156889008350 intermolecular recognition site; other site 156889008351 dimerization interface [polypeptide binding]; other site 156889008352 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 156889008353 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 156889008354 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 156889008355 Cl binding site [ion binding]; other site 156889008356 oligomer interface [polypeptide binding]; other site 156889008357 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 156889008358 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 156889008359 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 156889008360 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 156889008361 PhnA protein; Region: PhnA; pfam03831 156889008362 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 156889008363 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 156889008364 PAS domain S-box; Region: sensory_box; TIGR00229 156889008365 PAS domain; Region: PAS_8; pfam13188 156889008366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889008367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889008368 dimer interface [polypeptide binding]; other site 156889008369 phosphorylation site [posttranslational modification] 156889008370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889008371 ATP binding site [chemical binding]; other site 156889008372 Mg2+ binding site [ion binding]; other site 156889008373 G-X-G motif; other site 156889008374 Response regulator receiver domain; Region: Response_reg; pfam00072 156889008375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008376 active site 156889008377 phosphorylation site [posttranslational modification] 156889008378 intermolecular recognition site; other site 156889008379 dimerization interface [polypeptide binding]; other site 156889008380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 156889008381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 156889008382 putative substrate translocation pore; other site 156889008383 DNA topoisomerase III; Provisional; Region: PRK07726 156889008384 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 156889008385 active site 156889008386 putative interdomain interaction site [polypeptide binding]; other site 156889008387 putative metal-binding site [ion binding]; other site 156889008388 putative nucleotide binding site [chemical binding]; other site 156889008389 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 156889008390 domain I; other site 156889008391 DNA binding groove [nucleotide binding] 156889008392 phosphate binding site [ion binding]; other site 156889008393 domain II; other site 156889008394 domain III; other site 156889008395 nucleotide binding site [chemical binding]; other site 156889008396 catalytic site [active] 156889008397 domain IV; other site 156889008398 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 156889008399 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 156889008400 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 156889008401 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 156889008402 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 156889008403 Cache domain; Region: Cache_1; pfam02743 156889008404 HAMP domain; Region: HAMP; pfam00672 156889008405 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 156889008406 cyclase homology domain; Region: CHD; cd07302 156889008407 nucleotidyl binding site; other site 156889008408 metal binding site [ion binding]; metal-binding site 156889008409 dimer interface [polypeptide binding]; other site 156889008410 Sensors of blue-light using FAD; Region: BLUF; pfam04940 156889008411 Protein of unknown function (DUF2833); Region: DUF2833; cl17113 156889008412 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 156889008413 putative transposase OrfB; Reviewed; Region: PHA02517 156889008414 Integrase core domain; Region: rve; pfam00665 156889008415 Integrase core domain; Region: rve_3; pfam13683 156889008416 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 156889008417 active site 156889008418 Methyltransferase domain; Region: Methyltransf_23; pfam13489 156889008419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889008420 S-adenosylmethionine binding site [chemical binding]; other site 156889008421 TPR repeat; Region: TPR_11; pfam13414 156889008422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889008423 binding surface 156889008424 TPR repeat; Region: TPR_11; pfam13414 156889008425 TPR motif; other site 156889008426 TPR repeat; Region: TPR_11; pfam13414 156889008427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889008428 binding surface 156889008429 TPR motif; other site 156889008430 putative transposase OrfB; Reviewed; Region: PHA02517 156889008431 Integrase core domain; Region: rve; pfam00665 156889008432 Integrase core domain; Region: rve_3; pfam13683 156889008433 Transposase, Mutator family; Region: Transposase_mut; pfam00872 156889008434 MULE transposase domain; Region: MULE; pfam10551 156889008435 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 156889008436 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 156889008437 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889008438 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 156889008439 salt bridge; other site 156889008440 non-specific DNA binding site [nucleotide binding]; other site 156889008441 sequence-specific DNA binding site [nucleotide binding]; other site 156889008442 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 156889008443 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889008444 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889008445 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 156889008446 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 156889008447 tandem repeat interface [polypeptide binding]; other site 156889008448 oligomer interface [polypeptide binding]; other site 156889008449 active site residues [active] 156889008450 RelB antitoxin; Region: RelB; cl01171 156889008451 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 156889008452 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 156889008453 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 156889008454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 156889008455 ATP binding site [chemical binding]; other site 156889008456 putative Mg++ binding site [ion binding]; other site 156889008457 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 156889008458 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 156889008459 ParB-like nuclease domain; Region: ParBc; pfam02195 156889008460 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 156889008461 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 156889008462 DNA methylase; Region: N6_N4_Mtase; cl17433 156889008463 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889008464 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889008465 Winged helix-turn helix; Region: HTH_29; pfam13551 156889008466 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 156889008467 DNA-binding interface [nucleotide binding]; DNA binding site 156889008468 Homeodomain-like domain; Region: HTH_32; pfam13565 156889008469 DDE superfamily endonuclease; Region: DDE_3; pfam13358 156889008470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 156889008471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889008472 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 156889008473 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 156889008474 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889008475 HTH-like domain; Region: HTH_21; pfam13276 156889008476 Integrase core domain; Region: rve; pfam00665 156889008477 Integrase core domain; Region: rve_3; pfam13683 156889008478 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889008479 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889008480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889008481 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889008482 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889008483 Heat induced stress protein YflT; Region: YflT; pfam11181 156889008484 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 156889008485 active site 156889008486 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 156889008487 active site 156889008488 metal binding site [ion binding]; metal-binding site 156889008489 interdomain interaction site; other site 156889008490 AAA domain; Region: AAA_25; pfam13481 156889008491 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 156889008492 Walker A motif; other site 156889008493 ATP binding site [chemical binding]; other site 156889008494 Walker B motif; other site 156889008495 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 156889008496 ParB-like nuclease domain; Region: ParBc; cl02129 156889008497 MT-A70; Region: MT-A70; cl01947 156889008498 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 156889008499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889008500 ATP binding site [chemical binding]; other site 156889008501 putative Mg++ binding site [ion binding]; other site 156889008502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889008503 nucleotide binding region [chemical binding]; other site 156889008504 ATP-binding site [chemical binding]; other site 156889008505 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 156889008506 AAA domain; Region: AAA_24; pfam13479 156889008507 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 156889008508 Domain of unknown function (DUF955); Region: DUF955; pfam06114 156889008509 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 156889008510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889008511 non-specific DNA binding site [nucleotide binding]; other site 156889008512 salt bridge; other site 156889008513 sequence-specific DNA binding site [nucleotide binding]; other site 156889008514 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 156889008515 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 156889008516 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 156889008517 catalytic residues [active] 156889008518 catalytic nucleophile [active] 156889008519 Presynaptic Site I dimer interface [polypeptide binding]; other site 156889008520 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 156889008521 Synaptic Flat tetramer interface [polypeptide binding]; other site 156889008522 Synaptic Site I dimer interface [polypeptide binding]; other site 156889008523 DNA binding site [nucleotide binding] 156889008524 Recombinase; Region: Recombinase; pfam07508 156889008525 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 156889008526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889008527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889008528 dimer interface [polypeptide binding]; other site 156889008529 phosphorylation site [posttranslational modification] 156889008530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889008531 ATP binding site [chemical binding]; other site 156889008532 Mg2+ binding site [ion binding]; other site 156889008533 G-X-G motif; other site 156889008534 Response regulator receiver domain; Region: Response_reg; pfam00072 156889008535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008536 active site 156889008537 phosphorylation site [posttranslational modification] 156889008538 intermolecular recognition site; other site 156889008539 dimerization interface [polypeptide binding]; other site 156889008540 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889008541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889008542 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889008543 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889008544 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889008545 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889008546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889008547 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 156889008548 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 156889008549 Integrase core domain; Region: rve; pfam00665 156889008550 Integrase core domain; Region: rve_3; pfam13683 156889008551 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 156889008552 putative transposase OrfB; Reviewed; Region: PHA02517 156889008553 Integrase core domain; Region: rve; pfam00665 156889008554 Integrase core domain; Region: rve_3; pfam13683 156889008555 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889008556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889008557 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889008558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889008559 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889008560 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889008561 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889008562 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889008563 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 156889008564 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889008565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889008566 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889008567 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889008568 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889008569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889008570 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 156889008571 CheB methylesterase; Region: CheB_methylest; pfam01339 156889008572 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889008573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889008574 metal binding site [ion binding]; metal-binding site 156889008575 active site 156889008576 I-site; other site 156889008577 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889008578 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889008579 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 156889008580 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889008581 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 156889008582 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 156889008583 TrkA-N domain; Region: TrkA_N; pfam02254 156889008584 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 156889008585 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 156889008586 putative ligand binding site [chemical binding]; other site 156889008587 PAS domain S-box; Region: sensory_box; TIGR00229 156889008588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889008589 putative active site [active] 156889008590 heme pocket [chemical binding]; other site 156889008591 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889008592 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889008593 metal binding site [ion binding]; metal-binding site 156889008594 active site 156889008595 I-site; other site 156889008596 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889008597 Sensors of blue-light using FAD; Region: BLUF; pfam04940 156889008598 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889008599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008600 active site 156889008601 phosphorylation site [posttranslational modification] 156889008602 intermolecular recognition site; other site 156889008603 Transposase; Region: HTH_Tnp_1; pfam01527 156889008604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 156889008605 putative transposase OrfB; Reviewed; Region: PHA02517 156889008606 HTH-like domain; Region: HTH_21; pfam13276 156889008607 Integrase core domain; Region: rve; pfam00665 156889008608 Integrase core domain; Region: rve_3; pfam13683 156889008609 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 156889008610 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 156889008611 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 156889008612 putative ligand binding site [chemical binding]; other site 156889008613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 156889008614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889008615 dimerization interface [polypeptide binding]; other site 156889008616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889008617 putative active site [active] 156889008618 heme pocket [chemical binding]; other site 156889008619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889008620 dimer interface [polypeptide binding]; other site 156889008621 phosphorylation site [posttranslational modification] 156889008622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889008623 ATP binding site [chemical binding]; other site 156889008624 Mg2+ binding site [ion binding]; other site 156889008625 G-X-G motif; other site 156889008626 Response regulator receiver domain; Region: Response_reg; pfam00072 156889008627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008628 active site 156889008629 phosphorylation site [posttranslational modification] 156889008630 intermolecular recognition site; other site 156889008631 dimerization interface [polypeptide binding]; other site 156889008632 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889008633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889008634 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889008635 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889008636 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889008637 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889008638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889008639 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 156889008640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889008641 ATP binding site [chemical binding]; other site 156889008642 putative Mg++ binding site [ion binding]; other site 156889008643 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889008644 nucleotide binding region [chemical binding]; other site 156889008645 ATP-binding site [chemical binding]; other site 156889008646 Allantoicase [Nucleotide transport and metabolism]; Region: Alc; COG4266 156889008647 AAA domain; Region: AAA_24; pfam13479 156889008648 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 156889008649 Domain of unknown function (DUF955); Region: DUF955; pfam06114 156889008650 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 156889008651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889008652 non-specific DNA binding site [nucleotide binding]; other site 156889008653 salt bridge; other site 156889008654 sequence-specific DNA binding site [nucleotide binding]; other site 156889008655 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889008656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889008657 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889008658 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889008659 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889008660 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889008661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889008662 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 156889008663 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 156889008664 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 156889008665 catalytic residues [active] 156889008666 catalytic nucleophile [active] 156889008667 Presynaptic Site I dimer interface [polypeptide binding]; other site 156889008668 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 156889008669 Synaptic Flat tetramer interface [polypeptide binding]; other site 156889008670 Synaptic Site I dimer interface [polypeptide binding]; other site 156889008671 DNA binding site [nucleotide binding] 156889008672 Recombinase; Region: Recombinase; pfam07508 156889008673 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 156889008674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889008675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889008676 dimer interface [polypeptide binding]; other site 156889008677 phosphorylation site [posttranslational modification] 156889008678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889008679 ATP binding site [chemical binding]; other site 156889008680 Mg2+ binding site [ion binding]; other site 156889008681 G-X-G motif; other site 156889008682 Response regulator receiver domain; Region: Response_reg; pfam00072 156889008683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008684 active site 156889008685 phosphorylation site [posttranslational modification] 156889008686 intermolecular recognition site; other site 156889008687 dimerization interface [polypeptide binding]; other site 156889008688 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 156889008689 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 156889008690 substrate binding site; other site 156889008691 dimer interface; other site 156889008692 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 156889008693 homotrimer interaction site [polypeptide binding]; other site 156889008694 zinc binding site [ion binding]; other site 156889008695 CDP-binding sites; other site 156889008696 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 156889008697 multifunctional aminopeptidase A; Provisional; Region: PRK00913 156889008698 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 156889008699 interface (dimer of trimers) [polypeptide binding]; other site 156889008700 Substrate-binding/catalytic site; other site 156889008701 Zn-binding sites [ion binding]; other site 156889008702 Predicted permeases [General function prediction only]; Region: COG0795 156889008703 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 156889008704 Predicted permeases [General function prediction only]; Region: COG0795 156889008705 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 156889008706 Ion channel; Region: Ion_trans_2; pfam07885 156889008707 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 156889008708 TrkA-N domain; Region: TrkA_N; pfam02254 156889008709 TrkA-C domain; Region: TrkA_C; pfam02080 156889008710 Uncharacterized conserved protein [Function unknown]; Region: COG2928 156889008711 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 156889008712 catalytic core [active] 156889008713 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 156889008714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 156889008715 Coenzyme A binding pocket [chemical binding]; other site 156889008716 Double zinc ribbon; Region: DZR; pfam12773 156889008717 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 156889008718 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 156889008719 cyclase homology domain; Region: CHD; cd07302 156889008720 nucleotidyl binding site; other site 156889008721 metal binding site [ion binding]; metal-binding site 156889008722 dimer interface [polypeptide binding]; other site 156889008723 AAA ATPase domain; Region: AAA_16; pfam13191 156889008724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 156889008725 binding surface 156889008726 TPR motif; other site 156889008727 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889008728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889008729 TPR motif; other site 156889008730 binding surface 156889008731 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889008732 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889008733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889008734 binding surface 156889008735 TPR motif; other site 156889008736 EamA-like transporter family; Region: EamA; pfam00892 156889008737 Rubredoxin [Energy production and conversion]; Region: COG1773 156889008738 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 156889008739 iron binding site [ion binding]; other site 156889008740 TM2 domain; Region: TM2; pfam05154 156889008741 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 156889008742 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 156889008743 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 156889008744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008745 active site 156889008746 phosphorylation site [posttranslational modification] 156889008747 intermolecular recognition site; other site 156889008748 dimerization interface [polypeptide binding]; other site 156889008749 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 156889008750 DNA binding site [nucleotide binding] 156889008751 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889008752 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889008753 substrate binding pocket [chemical binding]; other site 156889008754 membrane-bound complex binding site; other site 156889008755 hinge residues; other site 156889008756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889008757 dimer interface [polypeptide binding]; other site 156889008758 phosphorylation site [posttranslational modification] 156889008759 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 156889008760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889008761 ATP binding site [chemical binding]; other site 156889008762 Mg2+ binding site [ion binding]; other site 156889008763 G-X-G motif; other site 156889008764 Response regulator receiver domain; Region: Response_reg; pfam00072 156889008765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008766 active site 156889008767 phosphorylation site [posttranslational modification] 156889008768 intermolecular recognition site; other site 156889008769 dimerization interface [polypeptide binding]; other site 156889008770 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 156889008771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008772 Response regulator receiver domain; Region: Response_reg; pfam00072 156889008773 active site 156889008774 phosphorylation site [posttranslational modification] 156889008775 intermolecular recognition site; other site 156889008776 dimerization interface [polypeptide binding]; other site 156889008777 haemagglutination activity domain; Region: Haemagg_act; pfam05860 156889008778 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 156889008779 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 156889008780 Surface antigen; Region: Bac_surface_Ag; pfam01103 156889008781 transposase/IS protein; Provisional; Region: PRK09183 156889008782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889008783 Walker A motif; other site 156889008784 ATP binding site [chemical binding]; other site 156889008785 Walker B motif; other site 156889008786 arginine finger; other site 156889008787 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 156889008788 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 156889008789 Integrase core domain; Region: rve; pfam00665 156889008790 Integrase core domain; Region: rve_3; pfam13683 156889008791 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 156889008792 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 156889008793 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 156889008794 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 156889008795 putative active site [active] 156889008796 putative NTP binding site [chemical binding]; other site 156889008797 putative nucleic acid binding site [nucleotide binding]; other site 156889008798 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 156889008799 Integrase core domain; Region: rve; pfam00665 156889008800 Integrase core domain; Region: rve_3; pfam13683 156889008801 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 156889008802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889008803 Walker A motif; other site 156889008804 ATP binding site [chemical binding]; other site 156889008805 Walker B motif; other site 156889008806 arginine finger; other site 156889008807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 156889008808 putative DNA binding site [nucleotide binding]; other site 156889008809 putative Zn2+ binding site [ion binding]; other site 156889008810 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 156889008811 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889008812 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889008813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008814 Response regulator receiver domain; Region: Response_reg; pfam00072 156889008815 active site 156889008816 phosphorylation site [posttranslational modification] 156889008817 intermolecular recognition site; other site 156889008818 dimerization interface [polypeptide binding]; other site 156889008819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889008820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889008821 ATP binding site [chemical binding]; other site 156889008822 Mg2+ binding site [ion binding]; other site 156889008823 G-X-G motif; other site 156889008824 AAA domain; Region: AAA_23; pfam13476 156889008825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889008826 Walker A/P-loop; other site 156889008827 ATP binding site [chemical binding]; other site 156889008828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889008829 ABC transporter signature motif; other site 156889008830 Walker B; other site 156889008831 D-loop; other site 156889008832 H-loop/switch region; other site 156889008833 Predicted transcriptional regulator [Transcription]; Region: COG2378 156889008834 WYL domain; Region: WYL; pfam13280 156889008835 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 156889008836 RNase_H superfamily; Region: RNase_H_2; pfam13482 156889008837 Part of AAA domain; Region: AAA_19; pfam13245 156889008838 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 156889008839 AAA domain; Region: AAA_12; pfam13087 156889008840 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 156889008841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889008842 ATP binding site [chemical binding]; other site 156889008843 putative Mg++ binding site [ion binding]; other site 156889008844 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 156889008845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889008846 nucleotide binding region [chemical binding]; other site 156889008847 ATP-binding site [chemical binding]; other site 156889008848 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 156889008849 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 156889008850 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 156889008851 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 156889008852 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 156889008853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 156889008854 Protein of unknown function (DUF499); Region: DUF499; pfam04465 156889008855 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 156889008856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 156889008857 Integrase core domain; Region: rve; pfam00665 156889008858 Integrase core domain; Region: rve_3; pfam13683 156889008859 Transposase IS200 like; Region: Y1_Tnp; pfam01797 156889008860 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889008861 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889008862 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 156889008863 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 156889008864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889008865 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 156889008866 salt bridge; other site 156889008867 non-specific DNA binding site [nucleotide binding]; other site 156889008868 sequence-specific DNA binding site [nucleotide binding]; other site 156889008869 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 156889008870 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889008871 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889008872 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 156889008873 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 156889008874 tandem repeat interface [polypeptide binding]; other site 156889008875 oligomer interface [polypeptide binding]; other site 156889008876 active site residues [active] 156889008877 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 156889008878 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 156889008879 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 156889008880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 156889008881 ATP binding site [chemical binding]; other site 156889008882 putative Mg++ binding site [ion binding]; other site 156889008883 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 156889008884 ParB-like nuclease domain; Region: ParBc; pfam02195 156889008885 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 156889008886 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 156889008887 DNA methylase; Region: N6_N4_Mtase; cl17433 156889008888 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 156889008889 active site 156889008890 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 156889008891 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 156889008892 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889008893 IHF dimer interface [polypeptide binding]; other site 156889008894 IHF - DNA interface [nucleotide binding]; other site 156889008895 Peptidase M15; Region: Peptidase_M15_3; cl01194 156889008896 Heat induced stress protein YflT; Region: YflT; pfam11181 156889008897 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 156889008898 active site 156889008899 metal binding site [ion binding]; metal-binding site 156889008900 interdomain interaction site; other site 156889008901 AAA domain; Region: AAA_25; pfam13481 156889008902 Hexameric Replicative Helicase RepA. RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125 156889008903 Walker A motif; other site 156889008904 NTP binding site [chemical binding]; other site 156889008905 hexamer interface [polypeptide binding]; other site 156889008906 Walker B motif; other site 156889008907 ORF6N domain; Region: ORF6N; pfam10543 156889008908 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 156889008909 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889008910 ATP binding site [chemical binding]; other site 156889008911 putative Mg++ binding site [ion binding]; other site 156889008912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889008913 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 156889008914 nucleotide binding region [chemical binding]; other site 156889008915 ATP-binding site [chemical binding]; other site 156889008916 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 156889008917 AAA domain; Region: AAA_24; pfam13479 156889008918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889008919 non-specific DNA binding site [nucleotide binding]; other site 156889008920 salt bridge; other site 156889008921 Predicted transcriptional regulator [Transcription]; Region: COG2932 156889008922 sequence-specific DNA binding site [nucleotide binding]; other site 156889008923 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 156889008924 Catalytic site [active] 156889008925 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 156889008926 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 156889008927 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 156889008928 catalytic residues [active] 156889008929 catalytic nucleophile [active] 156889008930 Recombinase; Region: Recombinase; pfam07508 156889008931 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 156889008932 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 156889008933 Membrane fusogenic activity; Region: BMFP; cl01115 156889008934 SEC-C motif; Region: SEC-C; pfam02810 156889008935 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 156889008936 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 156889008937 putative transposase OrfB; Reviewed; Region: PHA02517 156889008938 Integrase core domain; Region: rve; pfam00665 156889008939 Integrase core domain; Region: rve_3; pfam13683 156889008940 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889008941 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 156889008942 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 156889008943 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 156889008944 Uncharacterized conserved protein [Function unknown]; Region: COG5464 156889008945 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 156889008946 Integrase core domain; Region: rve_3; pfam13683 156889008947 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 156889008948 Uncharacterized conserved protein [Function unknown]; Region: COG1262 156889008949 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 156889008950 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 156889008951 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889008952 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 156889008953 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 156889008954 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 156889008955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 156889008956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 156889008957 Sporulation related domain; Region: SPOR; pfam05036 156889008958 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889008959 CENP-A-nucleosome distal (CAD) centromere subunit; Region: CENP-Q; pfam13094 156889008960 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 156889008961 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 156889008962 active site 156889008963 substrate binding site [chemical binding]; other site 156889008964 catalytic site [active] 156889008965 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 156889008966 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889008967 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889008968 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 156889008969 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 156889008970 tandem repeat interface [polypeptide binding]; other site 156889008971 oligomer interface [polypeptide binding]; other site 156889008972 active site residues [active] 156889008973 Response regulator receiver domain; Region: Response_reg; pfam00072 156889008974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889008975 active site 156889008976 phosphorylation site [posttranslational modification] 156889008977 intermolecular recognition site; other site 156889008978 dimerization interface [polypeptide binding]; other site 156889008979 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 156889008980 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 156889008981 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 156889008982 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 156889008983 ATP binding site [chemical binding]; other site 156889008984 putative Mg++ binding site [ion binding]; other site 156889008985 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 156889008986 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889008987 IHF dimer interface [polypeptide binding]; other site 156889008988 IHF - DNA interface [nucleotide binding]; other site 156889008989 ParB-like nuclease domain; Region: ParBc; pfam02195 156889008990 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 156889008991 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 156889008992 DNA methylase; Region: N6_N4_Mtase; cl17433 156889008993 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 156889008994 active site 156889008995 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 156889008996 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 156889008997 Peptidase M15; Region: Peptidase_M15_3; cl01194 156889008998 Hemerythrin; Region: Hemerythrin; cd12107 156889008999 Fe binding site [ion binding]; other site 156889009000 PilZ domain; Region: PilZ; pfam07238 156889009001 Endonuclease I; Region: Endonuclease_1; pfam04231 156889009002 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889009003 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889009004 IHF dimer interface [polypeptide binding]; other site 156889009005 IHF - DNA interface [nucleotide binding]; other site 156889009006 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 156889009007 active site 156889009008 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 156889009009 active site 156889009010 metal binding site [ion binding]; metal-binding site 156889009011 interdomain interaction site; other site 156889009012 AAA domain; Region: AAA_25; pfam13481 156889009013 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 156889009014 Walker A motif; other site 156889009015 ATP binding site [chemical binding]; other site 156889009016 Walker B motif; other site 156889009017 ORF6N domain; Region: ORF6N; pfam10543 156889009018 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 156889009019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889009020 ATP binding site [chemical binding]; other site 156889009021 putative Mg++ binding site [ion binding]; other site 156889009022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889009023 nucleotide binding region [chemical binding]; other site 156889009024 ATP-binding site [chemical binding]; other site 156889009025 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 156889009026 AAA domain; Region: AAA_24; pfam13479 156889009027 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 156889009028 Domain of unknown function (DUF955); Region: DUF955; pfam06114 156889009029 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 156889009030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889009031 non-specific DNA binding site [nucleotide binding]; other site 156889009032 salt bridge; other site 156889009033 sequence-specific DNA binding site [nucleotide binding]; other site 156889009034 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 156889009035 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 156889009036 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 156889009037 catalytic residues [active] 156889009038 catalytic nucleophile [active] 156889009039 Presynaptic Site I dimer interface [polypeptide binding]; other site 156889009040 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 156889009041 Synaptic Flat tetramer interface [polypeptide binding]; other site 156889009042 Synaptic Site I dimer interface [polypeptide binding]; other site 156889009043 DNA binding site [nucleotide binding] 156889009044 Recombinase; Region: Recombinase; pfam07508 156889009045 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 156889009046 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 156889009047 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 156889009048 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 156889009049 active site 156889009050 DNA binding site [nucleotide binding] 156889009051 Int/Topo IB signature motif; other site 156889009052 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 156889009053 Putative transposase; Region: Y2_Tnp; pfam04986 156889009054 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 156889009055 putative transposase OrfB; Reviewed; Region: PHA02517 156889009056 Integrase core domain; Region: rve; pfam00665 156889009057 Integrase core domain; Region: rve_3; pfam13683 156889009058 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889009059 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889009060 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889009061 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 156889009062 Ligand binding site; other site 156889009063 Putative Catalytic site; other site 156889009064 DXD motif; other site 156889009065 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 156889009066 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 156889009067 NAD binding site [chemical binding]; other site 156889009068 homotetramer interface [polypeptide binding]; other site 156889009069 homodimer interface [polypeptide binding]; other site 156889009070 active site 156889009071 substrate binding site [chemical binding]; other site 156889009072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 156889009073 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 156889009074 NAD(P) binding site [chemical binding]; other site 156889009075 active site 156889009076 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 156889009077 seadornavirus VP2 protein; Region: seadorna_VP2; TIGR04236 156889009078 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 156889009079 PIN domain; Region: PIN_3; pfam13470 156889009080 HicB family; Region: HicB; pfam05534 156889009081 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 156889009082 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889009083 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 156889009084 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 156889009085 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 156889009086 tandem repeat interface [polypeptide binding]; other site 156889009087 oligomer interface [polypeptide binding]; other site 156889009088 active site residues [active] 156889009089 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 156889009090 addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607 156889009091 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 156889009092 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 156889009093 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 156889009094 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 156889009095 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889009096 IHF - DNA interface [nucleotide binding]; other site 156889009097 IHF dimer interface [polypeptide binding]; other site 156889009098 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 156889009099 DNA-binding site [nucleotide binding]; DNA binding site 156889009100 RNA-binding motif; other site 156889009101 ParB-like nuclease domain; Region: ParBc; pfam02195 156889009102 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 156889009103 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 156889009104 DNA methylase; Region: N6_N4_Mtase; cl17433 156889009105 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 156889009106 IHF dimer interface [polypeptide binding]; other site 156889009107 IHF - DNA interface [nucleotide binding]; other site 156889009108 Peptidase M15; Region: Peptidase_M15_3; cl01194 156889009109 Heat induced stress protein YflT; Region: YflT; pfam11181 156889009110 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 156889009111 active site 156889009112 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 156889009113 polymerase nucleotide-binding site; other site 156889009114 DNA-binding residues [nucleotide binding]; DNA binding site 156889009115 nucleotide binding site [chemical binding]; other site 156889009116 primase nucleotide-binding site [nucleotide binding]; other site 156889009117 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 156889009118 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 156889009119 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 156889009120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889009121 ATP binding site [chemical binding]; other site 156889009122 putative Mg++ binding site [ion binding]; other site 156889009123 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889009124 nucleotide binding region [chemical binding]; other site 156889009125 ATP-binding site [chemical binding]; other site 156889009126 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 156889009127 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 156889009128 Protein of unknown function (DUF669); Region: DUF669; pfam05037 156889009129 AAA domain; Region: AAA_24; pfam13479 156889009130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889009131 non-specific DNA binding site [nucleotide binding]; other site 156889009132 salt bridge; other site 156889009133 Predicted transcriptional regulator [Transcription]; Region: COG2932 156889009134 sequence-specific DNA binding site [nucleotide binding]; other site 156889009135 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 156889009136 Catalytic site [active] 156889009137 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 156889009138 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 156889009139 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 156889009140 catalytic residues [active] 156889009141 catalytic nucleophile [active] 156889009142 Recombinase; Region: Recombinase; pfam07508 156889009143 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 156889009144 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 156889009145 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 156889009146 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 156889009147 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 156889009148 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 156889009149 dimer interface [polypeptide binding]; other site 156889009150 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 156889009151 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889009152 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889009153 dimer interface [polypeptide binding]; other site 156889009154 putative CheW interface [polypeptide binding]; other site 156889009155 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889009156 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 156889009157 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 156889009158 active site 156889009159 hydroxyglutarate oxidase; Provisional; Region: PRK11728 156889009160 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 156889009161 N-acetylglutamate synthase; Validated; Region: PRK05279 156889009162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 156889009163 Coenzyme A binding pocket [chemical binding]; other site 156889009164 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 156889009165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 156889009166 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889009167 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889009168 dimer interface [polypeptide binding]; other site 156889009169 putative CheW interface [polypeptide binding]; other site 156889009170 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889009171 Hemerythrin; Region: Hemerythrin; cd12107 156889009172 Fe binding site [ion binding]; other site 156889009173 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 156889009174 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 156889009175 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 156889009176 Peptidase M16C associated; Region: M16C_assoc; pfam08367 156889009177 muropeptide transporter; Validated; Region: ampG; cl17669 156889009178 muropeptide transporter; Reviewed; Region: ampG; PRK11902 156889009179 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 156889009180 putative active site pocket [active] 156889009181 4-fold oligomerization interface [polypeptide binding]; other site 156889009182 metal binding residues [ion binding]; metal-binding site 156889009183 3-fold/trimer interface [polypeptide binding]; other site 156889009184 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 156889009185 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 156889009186 putative active site [active] 156889009187 oxyanion strand; other site 156889009188 catalytic triad [active] 156889009189 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 156889009190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889009191 Walker A/P-loop; other site 156889009192 ATP binding site [chemical binding]; other site 156889009193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889009194 Q-loop/lid; other site 156889009195 ABC transporter signature motif; other site 156889009196 Walker B; other site 156889009197 D-loop; other site 156889009198 H-loop/switch region; other site 156889009199 TIGR02646 family protein; Region: TIGR02646 156889009200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009201 PAS domain; Region: PAS_9; pfam13426 156889009202 putative active site [active] 156889009203 heme pocket [chemical binding]; other site 156889009204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889009205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009206 ATP binding site [chemical binding]; other site 156889009207 Mg2+ binding site [ion binding]; other site 156889009208 G-X-G motif; other site 156889009209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009210 active site 156889009211 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 156889009212 phosphorylation site [posttranslational modification] 156889009213 intermolecular recognition site; other site 156889009214 dimerization interface [polypeptide binding]; other site 156889009215 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889009216 metal binding site [ion binding]; metal-binding site 156889009217 active site 156889009218 I-site; other site 156889009219 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 156889009220 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889009221 Zn2+ binding site [ion binding]; other site 156889009222 Mg2+ binding site [ion binding]; other site 156889009223 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 156889009224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009225 active site 156889009226 phosphorylation site [posttranslational modification] 156889009227 intermolecular recognition site; other site 156889009228 dimerization interface [polypeptide binding]; other site 156889009229 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889009230 Zn2+ binding site [ion binding]; other site 156889009231 Mg2+ binding site [ion binding]; other site 156889009232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009233 PAS domain; Region: PAS_9; pfam13426 156889009234 putative active site [active] 156889009235 heme pocket [chemical binding]; other site 156889009236 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889009237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009238 putative active site [active] 156889009239 heme pocket [chemical binding]; other site 156889009240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889009241 dimer interface [polypeptide binding]; other site 156889009242 phosphorylation site [posttranslational modification] 156889009243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009244 ATP binding site [chemical binding]; other site 156889009245 Mg2+ binding site [ion binding]; other site 156889009246 G-X-G motif; other site 156889009247 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889009248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009249 active site 156889009250 phosphorylation site [posttranslational modification] 156889009251 intermolecular recognition site; other site 156889009252 dimerization interface [polypeptide binding]; other site 156889009253 Response regulator receiver domain; Region: Response_reg; pfam00072 156889009254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009255 active site 156889009256 phosphorylation site [posttranslational modification] 156889009257 intermolecular recognition site; other site 156889009258 dimerization interface [polypeptide binding]; other site 156889009259 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889009260 putative binding surface; other site 156889009261 active site 156889009262 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 156889009263 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 156889009264 DNA-binding site [nucleotide binding]; DNA binding site 156889009265 RNA-binding motif; other site 156889009266 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 156889009267 non-heme iron binding site [ion binding]; other site 156889009268 tetramer interface [polypeptide binding]; other site 156889009269 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889009270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009271 putative active site [active] 156889009272 heme pocket [chemical binding]; other site 156889009273 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889009274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009275 putative active site [active] 156889009276 heme pocket [chemical binding]; other site 156889009277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009278 putative active site [active] 156889009279 heme pocket [chemical binding]; other site 156889009280 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889009281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889009282 dimer interface [polypeptide binding]; other site 156889009283 phosphorylation site [posttranslational modification] 156889009284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009285 ATP binding site [chemical binding]; other site 156889009286 Mg2+ binding site [ion binding]; other site 156889009287 G-X-G motif; other site 156889009288 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889009289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009290 active site 156889009291 phosphorylation site [posttranslational modification] 156889009292 intermolecular recognition site; other site 156889009293 dimerization interface [polypeptide binding]; other site 156889009294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889009295 dimerization interface [polypeptide binding]; other site 156889009296 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889009297 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889009298 dimer interface [polypeptide binding]; other site 156889009299 putative CheW interface [polypeptide binding]; other site 156889009300 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889009301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009302 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889009303 putative active site [active] 156889009304 heme pocket [chemical binding]; other site 156889009305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009306 putative active site [active] 156889009307 heme pocket [chemical binding]; other site 156889009308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009309 PAS fold; Region: PAS_3; pfam08447 156889009310 putative active site [active] 156889009311 heme pocket [chemical binding]; other site 156889009312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889009313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889009314 dimer interface [polypeptide binding]; other site 156889009315 phosphorylation site [posttranslational modification] 156889009316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009317 ATP binding site [chemical binding]; other site 156889009318 Mg2+ binding site [ion binding]; other site 156889009319 G-X-G motif; other site 156889009320 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889009321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009322 active site 156889009323 phosphorylation site [posttranslational modification] 156889009324 intermolecular recognition site; other site 156889009325 dimerization interface [polypeptide binding]; other site 156889009326 Response regulator receiver domain; Region: Response_reg; pfam00072 156889009327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009328 active site 156889009329 phosphorylation site [posttranslational modification] 156889009330 intermolecular recognition site; other site 156889009331 dimerization interface [polypeptide binding]; other site 156889009332 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 156889009333 Uncharacterized conserved protein [Function unknown]; Region: COG3287 156889009334 FIST N domain; Region: FIST; pfam08495 156889009335 FIST C domain; Region: FIST_C; pfam10442 156889009336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889009337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889009338 dimer interface [polypeptide binding]; other site 156889009339 phosphorylation site [posttranslational modification] 156889009340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009341 ATP binding site [chemical binding]; other site 156889009342 Mg2+ binding site [ion binding]; other site 156889009343 G-X-G motif; other site 156889009344 Response regulator receiver domain; Region: Response_reg; pfam00072 156889009345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009346 active site 156889009347 phosphorylation site [posttranslational modification] 156889009348 intermolecular recognition site; other site 156889009349 dimerization interface [polypeptide binding]; other site 156889009350 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889009351 putative binding surface; other site 156889009352 active site 156889009353 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889009354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009355 active site 156889009356 phosphorylation site [posttranslational modification] 156889009357 intermolecular recognition site; other site 156889009358 dimerization interface [polypeptide binding]; other site 156889009359 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 156889009360 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889009361 anti sigma factor interaction site; other site 156889009362 regulatory phosphorylation site [posttranslational modification]; other site 156889009363 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 156889009364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 156889009365 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 156889009366 dimerization interface [polypeptide binding]; other site 156889009367 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 156889009368 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 156889009369 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 156889009370 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889009371 dimerization interface [polypeptide binding]; other site 156889009372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889009373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009374 ATP binding site [chemical binding]; other site 156889009375 Mg2+ binding site [ion binding]; other site 156889009376 G-X-G motif; other site 156889009377 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 156889009378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889009379 FeS/SAM binding site; other site 156889009380 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 156889009381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 156889009382 2-isopropylmalate synthase; Validated; Region: PRK03739 156889009383 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 156889009384 active site 156889009385 catalytic residues [active] 156889009386 metal binding site [ion binding]; metal-binding site 156889009387 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 156889009388 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 156889009389 Low molecular weight phosphatase family; Region: LMWPc; cl00105 156889009390 active site 156889009391 Peptidase family M48; Region: Peptidase_M48; cl12018 156889009392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889009393 binding surface 156889009394 TPR motif; other site 156889009395 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 156889009396 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 156889009397 active site 156889009398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 156889009399 dimerization interface [polypeptide binding]; other site 156889009400 putative DNA binding site [nucleotide binding]; other site 156889009401 putative Zn2+ binding site [ion binding]; other site 156889009402 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 156889009403 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 156889009404 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 156889009405 Major Facilitator Superfamily; Region: MFS_1; pfam07690 156889009406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 156889009407 HAMP domain; Region: HAMP; pfam00672 156889009408 PAS domain S-box; Region: sensory_box; TIGR00229 156889009409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009410 putative active site [active] 156889009411 heme pocket [chemical binding]; other site 156889009412 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009413 PAS domain; Region: PAS_9; pfam13426 156889009414 putative active site [active] 156889009415 heme pocket [chemical binding]; other site 156889009416 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889009417 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889009418 metal binding site [ion binding]; metal-binding site 156889009419 active site 156889009420 I-site; other site 156889009421 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889009422 Cache domain; Region: Cache_1; pfam02743 156889009423 HAMP domain; Region: HAMP; pfam00672 156889009424 dimerization interface [polypeptide binding]; other site 156889009425 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889009426 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889009427 active site 156889009428 I-site; other site 156889009429 metal binding site [ion binding]; metal-binding site 156889009430 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 156889009431 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 156889009432 putative active site [active] 156889009433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889009434 TPR motif; other site 156889009435 binding surface 156889009436 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 156889009437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889009438 binding surface 156889009439 TPR motif; other site 156889009440 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 156889009441 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 156889009442 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 156889009443 GAF domain; Region: GAF_3; pfam13492 156889009444 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 156889009445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889009446 binding surface 156889009447 TPR motif; other site 156889009448 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 156889009449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889009450 Predicted membrane protein [Function unknown]; Region: COG4267 156889009451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 156889009452 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 156889009453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889009454 binding surface 156889009455 TPR motif; other site 156889009456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889009457 binding surface 156889009458 TPR motif; other site 156889009459 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 156889009460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889009461 TPR motif; other site 156889009462 binding surface 156889009463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889009464 binding surface 156889009465 TPR motif; other site 156889009466 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 156889009467 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 156889009468 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 156889009469 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 156889009470 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 156889009471 linker region; other site 156889009472 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889009473 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 156889009474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 156889009475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889009476 Walker A/P-loop; other site 156889009477 ATP binding site [chemical binding]; other site 156889009478 Q-loop/lid; other site 156889009479 ABC transporter signature motif; other site 156889009480 Walker B; other site 156889009481 D-loop; other site 156889009482 H-loop/switch region; other site 156889009483 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 156889009484 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 156889009485 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 156889009486 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 156889009487 active site 156889009488 multimer interface [polypeptide binding]; other site 156889009489 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 156889009490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889009491 FeS/SAM binding site; other site 156889009492 Domain of unknown function DUF302; Region: DUF302; cl01364 156889009493 Cytochrome c553 [Energy production and conversion]; Region: COG2863 156889009494 Cytochrome c; Region: Cytochrom_C; cl11414 156889009495 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 156889009496 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 156889009497 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 156889009498 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 156889009499 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 156889009500 Cache domain; Region: Cache_1; pfam02743 156889009501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889009502 dimerization interface [polypeptide binding]; other site 156889009503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009504 PAS domain; Region: PAS_9; pfam13426 156889009505 putative active site [active] 156889009506 heme pocket [chemical binding]; other site 156889009507 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 156889009508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889009509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889009510 dimer interface [polypeptide binding]; other site 156889009511 phosphorylation site [posttranslational modification] 156889009512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009513 ATP binding site [chemical binding]; other site 156889009514 Mg2+ binding site [ion binding]; other site 156889009515 G-X-G motif; other site 156889009516 Response regulator receiver domain; Region: Response_reg; pfam00072 156889009517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009518 active site 156889009519 phosphorylation site [posttranslational modification] 156889009520 intermolecular recognition site; other site 156889009521 dimerization interface [polypeptide binding]; other site 156889009522 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 156889009523 VacJ like lipoprotein; Region: VacJ; cl01073 156889009524 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889009525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889009526 binding surface 156889009527 TPR motif; other site 156889009528 TPR repeat; Region: TPR_11; pfam13414 156889009529 SnoaL-like domain; Region: SnoaL_3; pfam13474 156889009530 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 156889009531 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 156889009532 nudix motif; other site 156889009533 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 156889009534 nudix motif; other site 156889009535 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 156889009536 active site 156889009537 dimerization interface [polypeptide binding]; other site 156889009538 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 156889009539 dimerization interface [polypeptide binding]; other site 156889009540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889009541 dimer interface [polypeptide binding]; other site 156889009542 phosphorylation site [posttranslational modification] 156889009543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009544 ATP binding site [chemical binding]; other site 156889009545 Mg2+ binding site [ion binding]; other site 156889009546 G-X-G motif; other site 156889009547 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 156889009548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009549 active site 156889009550 phosphorylation site [posttranslational modification] 156889009551 intermolecular recognition site; other site 156889009552 dimerization interface [polypeptide binding]; other site 156889009553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889009554 Walker A motif; other site 156889009555 ATP binding site [chemical binding]; other site 156889009556 Walker B motif; other site 156889009557 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 156889009558 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 156889009559 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889009560 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889009561 metal binding site [ion binding]; metal-binding site 156889009562 active site 156889009563 I-site; other site 156889009564 GMP synthase; Reviewed; Region: guaA; PRK00074 156889009565 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 156889009566 AMP/PPi binding site [chemical binding]; other site 156889009567 candidate oxyanion hole; other site 156889009568 catalytic triad [active] 156889009569 potential glutamine specificity residues [chemical binding]; other site 156889009570 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 156889009571 ATP Binding subdomain [chemical binding]; other site 156889009572 Ligand Binding sites [chemical binding]; other site 156889009573 Dimerization subdomain; other site 156889009574 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 156889009575 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 156889009576 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 156889009577 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 156889009578 active site 156889009579 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 156889009580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889009581 S-adenosylmethionine binding site [chemical binding]; other site 156889009582 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 156889009583 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 156889009584 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 156889009585 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 156889009586 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 156889009587 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 156889009588 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 156889009589 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 156889009590 ATP-grasp domain; Region: ATP-grasp_4; cl17255 156889009591 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 156889009592 IMP binding site; other site 156889009593 dimer interface [polypeptide binding]; other site 156889009594 interdomain contacts; other site 156889009595 partial ornithine binding site; other site 156889009596 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 156889009597 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 156889009598 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 156889009599 catalytic site [active] 156889009600 subunit interface [polypeptide binding]; other site 156889009601 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 156889009602 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 156889009603 protein binding site [polypeptide binding]; other site 156889009604 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 156889009605 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 156889009606 active site 156889009607 Response regulator receiver domain; Region: Response_reg; pfam00072 156889009608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009609 active site 156889009610 phosphorylation site [posttranslational modification] 156889009611 intermolecular recognition site; other site 156889009612 dimerization interface [polypeptide binding]; other site 156889009613 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 156889009614 6-phosphofructokinase; Provisional; Region: PRK03202 156889009615 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 156889009616 active site 156889009617 ADP/pyrophosphate binding site [chemical binding]; other site 156889009618 dimerization interface [polypeptide binding]; other site 156889009619 allosteric effector site; other site 156889009620 fructose-1,6-bisphosphate binding site; other site 156889009621 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 156889009622 Response regulator receiver domain; Region: Response_reg; pfam00072 156889009623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009624 active site 156889009625 phosphorylation site [posttranslational modification] 156889009626 intermolecular recognition site; other site 156889009627 dimerization interface [polypeptide binding]; other site 156889009628 PilZ domain; Region: PilZ; pfam07238 156889009629 Response regulator receiver domain; Region: Response_reg; pfam00072 156889009630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009631 active site 156889009632 phosphorylation site [posttranslational modification] 156889009633 intermolecular recognition site; other site 156889009634 dimerization interface [polypeptide binding]; other site 156889009635 PAS domain; Region: PAS_9; pfam13426 156889009636 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889009637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009638 active site 156889009639 phosphorylation site [posttranslational modification] 156889009640 intermolecular recognition site; other site 156889009641 dimerization interface [polypeptide binding]; other site 156889009642 cyclase homology domain; Region: CHD; cd07302 156889009643 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 156889009644 nucleotidyl binding site; other site 156889009645 metal binding site [ion binding]; metal-binding site 156889009646 dimer interface [polypeptide binding]; other site 156889009647 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 156889009648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009649 active site 156889009650 phosphorylation site [posttranslational modification] 156889009651 intermolecular recognition site; other site 156889009652 PAS domain S-box; Region: sensory_box; TIGR00229 156889009653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009654 putative active site [active] 156889009655 heme pocket [chemical binding]; other site 156889009656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009657 PAS fold; Region: PAS_3; pfam08447 156889009658 putative active site [active] 156889009659 heme pocket [chemical binding]; other site 156889009660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009661 PAS domain; Region: PAS_9; pfam13426 156889009662 putative active site [active] 156889009663 heme pocket [chemical binding]; other site 156889009664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889009665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009666 ATP binding site [chemical binding]; other site 156889009667 Mg2+ binding site [ion binding]; other site 156889009668 G-X-G motif; other site 156889009669 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 156889009670 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889009671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009672 putative active site [active] 156889009673 heme pocket [chemical binding]; other site 156889009674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889009675 putative active site [active] 156889009676 heme pocket [chemical binding]; other site 156889009677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889009678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009679 ATP binding site [chemical binding]; other site 156889009680 G-X-G motif; other site 156889009681 Methyltransferase domain; Region: Methyltransf_24; pfam13578 156889009682 S-adenosylmethionine binding site [chemical binding]; other site 156889009683 Methyltransferase domain; Region: Methyltransf_11; pfam08241 156889009684 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 156889009685 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 156889009686 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 156889009687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 156889009688 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 156889009689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 156889009690 DNA binding residues [nucleotide binding] 156889009691 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 156889009692 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 156889009693 P-loop; other site 156889009694 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 156889009695 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 156889009696 Protein of unknown function, DUF258; Region: DUF258; pfam03193 156889009697 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 156889009698 flagellar biosynthesis protein FlhA; Region: FlhA; TIGR01398 156889009699 FHIPEP family; Region: FHIPEP; pfam00771 156889009700 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 156889009701 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 156889009702 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 156889009703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 156889009704 Major Facilitator Superfamily; Region: MFS_1; pfam07690 156889009705 putative substrate translocation pore; other site 156889009706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 156889009707 Methyltransferase domain; Region: Methyltransf_23; pfam13489 156889009708 Methyltransferase domain; Region: Methyltransf_12; pfam08242 156889009709 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 156889009710 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 156889009711 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 156889009712 gating phenylalanine in ion channel; other site 156889009713 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 156889009714 WYL domain; Region: WYL; pfam13280 156889009715 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 156889009716 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 156889009717 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 156889009718 catalytic loop [active] 156889009719 iron binding site [ion binding]; other site 156889009720 chaperone protein HscA; Provisional; Region: hscA; PRK05183 156889009721 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 156889009722 nucleotide binding site [chemical binding]; other site 156889009723 putative NEF/HSP70 interaction site [polypeptide binding]; other site 156889009724 SBD interface [polypeptide binding]; other site 156889009725 co-chaperone HscB; Provisional; Region: hscB; PRK05014 156889009726 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 156889009727 HSP70 interaction site [polypeptide binding]; other site 156889009728 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 156889009729 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 156889009730 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 156889009731 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 156889009732 trimerization site [polypeptide binding]; other site 156889009733 active site 156889009734 cysteine desulfurase IscS; Region: IscS; TIGR02006 156889009735 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 156889009736 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 156889009737 catalytic residue [active] 156889009738 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 156889009739 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 156889009740 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 156889009741 catalytic residue [active] 156889009742 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 156889009743 Rrf2 family protein; Region: rrf2_super; TIGR00738 156889009744 serine O-acetyltransferase; Region: cysE; TIGR01172 156889009745 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 156889009746 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 156889009747 trimer interface [polypeptide binding]; other site 156889009748 active site 156889009749 substrate binding site [chemical binding]; other site 156889009750 CoA binding site [chemical binding]; other site 156889009751 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889009752 anti sigma factor interaction site; other site 156889009753 regulatory phosphorylation site [posttranslational modification]; other site 156889009754 PAS fold; Region: PAS_3; pfam08447 156889009755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889009756 dimer interface [polypeptide binding]; other site 156889009757 phosphorylation site [posttranslational modification] 156889009758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009759 ATP binding site [chemical binding]; other site 156889009760 Mg2+ binding site [ion binding]; other site 156889009761 G-X-G motif; other site 156889009762 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889009763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009764 active site 156889009765 phosphorylation site [posttranslational modification] 156889009766 intermolecular recognition site; other site 156889009767 dimerization interface [polypeptide binding]; other site 156889009768 Response regulator receiver domain; Region: Response_reg; pfam00072 156889009769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009770 active site 156889009771 phosphorylation site [posttranslational modification] 156889009772 intermolecular recognition site; other site 156889009773 dimerization interface [polypeptide binding]; other site 156889009774 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 156889009775 putative binding surface; other site 156889009776 active site 156889009777 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889009778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009779 active site 156889009780 phosphorylation site [posttranslational modification] 156889009781 intermolecular recognition site; other site 156889009782 dimerization interface [polypeptide binding]; other site 156889009783 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 156889009784 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 156889009785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009786 active site 156889009787 phosphorylation site [posttranslational modification] 156889009788 intermolecular recognition site; other site 156889009789 dimerization interface [polypeptide binding]; other site 156889009790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889009791 Zn2+ binding site [ion binding]; other site 156889009792 Mg2+ binding site [ion binding]; other site 156889009793 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 156889009794 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 156889009795 MgtE intracellular N domain; Region: MgtE_N; smart00924 156889009796 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 156889009797 Divalent cation transporter; Region: MgtE; pfam01769 156889009798 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 156889009799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889009800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889009801 dimer interface [polypeptide binding]; other site 156889009802 phosphorylation site [posttranslational modification] 156889009803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889009804 ATP binding site [chemical binding]; other site 156889009805 Mg2+ binding site [ion binding]; other site 156889009806 G-X-G motif; other site 156889009807 Response regulator receiver domain; Region: Response_reg; pfam00072 156889009808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889009809 active site 156889009810 phosphorylation site [posttranslational modification] 156889009811 intermolecular recognition site; other site 156889009812 dimerization interface [polypeptide binding]; other site 156889009813 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 156889009814 Mechanosensitive ion channel; Region: MS_channel; pfam00924 156889009815 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 156889009816 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 156889009817 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 156889009818 DNA binding residues [nucleotide binding] 156889009819 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 156889009820 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 156889009821 putative dimer interface [polypeptide binding]; other site 156889009822 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 156889009823 DNA-binding site [nucleotide binding]; DNA binding site 156889009824 RNA-binding motif; other site 156889009825 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 156889009826 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 156889009827 glutathione synthetase; Provisional; Region: PRK12458 156889009828 ATP-grasp domain; Region: ATP-grasp_4; cl17255 156889009829 conserved hypothetical protein; Region: QEGLA; TIGR02421 156889009830 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 156889009831 transcriptional regulator HdfR; Provisional; Region: PRK03601 156889009832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 156889009833 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 156889009834 dimerization interface [polypeptide binding]; other site 156889009835 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 156889009836 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 156889009837 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889009838 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 156889009839 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889009840 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 156889009841 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 156889009842 Ligand Binding Site [chemical binding]; other site 156889009843 carbon storage regulator; Provisional; Region: PRK01712 156889009844 FlgN protein; Region: FlgN; pfam05130 156889009845 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 156889009846 Rod binding protein; Region: Rod-binding; cl01626 156889009847 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 156889009848 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 156889009849 Flagellar L-ring protein; Region: FlgH; pfam02107 156889009850 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 156889009851 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 156889009852 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 156889009853 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 156889009854 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 156889009855 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 156889009856 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 156889009857 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 156889009858 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 156889009859 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 156889009860 homodimer interface [polypeptide binding]; other site 156889009861 metal binding site [ion binding]; metal-binding site 156889009862 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 156889009863 homodimer interface [polypeptide binding]; other site 156889009864 active site 156889009865 putative chemical substrate binding site [chemical binding]; other site 156889009866 metal binding site [ion binding]; metal-binding site 156889009867 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889009868 anti sigma factor interaction site; other site 156889009869 regulatory phosphorylation site [posttranslational modification]; other site 156889009870 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 156889009871 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 156889009872 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 156889009873 Hemerythrin; Region: Hemerythrin; cd12107 156889009874 Fe binding site [ion binding]; other site 156889009875 PilZ domain; Region: PilZ; pfam07238 156889009876 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 156889009877 Cytochrome c; Region: Cytochrom_C; cl11414 156889009878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889009879 Walker A/P-loop; other site 156889009880 ATP binding site [chemical binding]; other site 156889009881 ABC transporter; Region: ABC_tran; pfam00005 156889009882 Q-loop/lid; other site 156889009883 ABC transporter signature motif; other site 156889009884 Walker B; other site 156889009885 D-loop; other site 156889009886 H-loop/switch region; other site 156889009887 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 156889009888 hypothetical protein; Validated; Region: PRK02101 156889009889 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 156889009890 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 156889009891 cyclase homology domain; Region: CHD; cd07302 156889009892 nucleotidyl binding site; other site 156889009893 metal binding site [ion binding]; metal-binding site 156889009894 dimer interface [polypeptide binding]; other site 156889009895 RNase_H superfamily; Region: RNase_H_2; pfam13482 156889009896 active site 156889009897 substrate binding site [chemical binding]; other site 156889009898 catalytic site [active] 156889009899 Methyltransferase domain; Region: Methyltransf_23; pfam13489 156889009900 Methyltransferase domain; Region: Methyltransf_12; pfam08242 156889009901 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 156889009902 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889009903 Zn2+ binding site [ion binding]; other site 156889009904 Mg2+ binding site [ion binding]; other site 156889009905 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 156889009906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 156889009907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889009908 homodimer interface [polypeptide binding]; other site 156889009909 catalytic residue [active] 156889009910 cobyric acid synthase; Provisional; Region: PRK00784 156889009911 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 156889009912 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 156889009913 catalytic triad [active] 156889009914 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 156889009915 active site 156889009916 SAM binding site [chemical binding]; other site 156889009917 homodimer interface [polypeptide binding]; other site 156889009918 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 156889009919 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 156889009920 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 156889009921 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 156889009922 active site 156889009923 SAM binding site [chemical binding]; other site 156889009924 homodimer interface [polypeptide binding]; other site 156889009925 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 156889009926 active site 156889009927 putative homodimer interface [polypeptide binding]; other site 156889009928 SAM binding site [chemical binding]; other site 156889009929 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 156889009930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889009931 S-adenosylmethionine binding site [chemical binding]; other site 156889009932 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 156889009933 Precorrin-8X methylmutase; Region: CbiC; pfam02570 156889009934 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 156889009935 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 156889009936 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 156889009937 putative active site [active] 156889009938 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 156889009939 putative active site [active] 156889009940 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 156889009941 active site 156889009942 SAM binding site [chemical binding]; other site 156889009943 homodimer interface [polypeptide binding]; other site 156889009944 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 156889009945 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 156889009946 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 156889009947 catalytic triad [active] 156889009948 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 156889009949 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 156889009950 Walker A/P-loop; other site 156889009951 ATP binding site [chemical binding]; other site 156889009952 Q-loop/lid; other site 156889009953 ABC transporter signature motif; other site 156889009954 Walker B; other site 156889009955 D-loop; other site 156889009956 H-loop/switch region; other site 156889009957 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 156889009958 cobalt transport protein CbiM; Validated; Region: PRK06265 156889009959 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 156889009960 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 156889009961 cyclase homology domain; Region: CHD; cd07302 156889009962 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 156889009963 nucleotidyl binding site; other site 156889009964 metal binding site [ion binding]; metal-binding site 156889009965 dimer interface [polypeptide binding]; other site 156889009966 FHA domain; Region: FHA; pfam00498 156889009967 phosphopeptide binding site; other site 156889009968 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 156889009969 active site 156889009970 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 156889009971 dimer interface [polypeptide binding]; other site 156889009972 active site 156889009973 Schiff base residues; other site 156889009974 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 156889009975 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 156889009976 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 156889009977 PIN domain; Region: PIN_3; cl17397 156889009978 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 156889009979 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 156889009980 CPxP motif; other site 156889009981 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 156889009982 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 156889009983 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 156889009984 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 156889009985 HAMP domain; Region: HAMP; pfam00672 156889009986 dimerization interface [polypeptide binding]; other site 156889009987 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889009988 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889009989 metal binding site [ion binding]; metal-binding site 156889009990 active site 156889009991 I-site; other site 156889009992 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 156889009993 GTPase RsgA; Reviewed; Region: PRK12288 156889009994 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 156889009995 RNA binding site [nucleotide binding]; other site 156889009996 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 156889009997 GTPase/Zn-binding domain interface [polypeptide binding]; other site 156889009998 GTP/Mg2+ binding site [chemical binding]; other site 156889009999 G4 box; other site 156889010000 G5 box; other site 156889010001 G1 box; other site 156889010002 Switch I region; other site 156889010003 G2 box; other site 156889010004 G3 box; other site 156889010005 Switch II region; other site 156889010006 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 156889010007 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 156889010008 catalytic residues [active] 156889010009 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 156889010010 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 156889010011 substrate binding site [chemical binding]; other site 156889010012 glutamase interaction surface [polypeptide binding]; other site 156889010013 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 156889010014 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 156889010015 metal binding site [ion binding]; metal-binding site 156889010016 PilZ domain; Region: PilZ; pfam07238 156889010017 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 156889010018 nucleotide binding site/active site [active] 156889010019 HIT family signature motif; other site 156889010020 catalytic residue [active] 156889010021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 156889010022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 156889010023 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 156889010024 Protein export membrane protein; Region: SecD_SecF; cl14618 156889010025 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 156889010026 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 156889010027 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889010028 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889010029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 156889010030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010031 PAS domain; Region: PAS_9; pfam13426 156889010032 putative active site [active] 156889010033 heme pocket [chemical binding]; other site 156889010034 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 156889010035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010036 putative active site [active] 156889010037 heme pocket [chemical binding]; other site 156889010038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010039 dimer interface [polypeptide binding]; other site 156889010040 phosphorylation site [posttranslational modification] 156889010041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010042 ATP binding site [chemical binding]; other site 156889010043 Mg2+ binding site [ion binding]; other site 156889010044 G-X-G motif; other site 156889010045 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 156889010046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010047 active site 156889010048 phosphorylation site [posttranslational modification] 156889010049 intermolecular recognition site; other site 156889010050 dimerization interface [polypeptide binding]; other site 156889010051 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010053 active site 156889010054 phosphorylation site [posttranslational modification] 156889010055 intermolecular recognition site; other site 156889010056 dimerization interface [polypeptide binding]; other site 156889010057 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889010058 putative binding surface; other site 156889010059 active site 156889010060 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 156889010061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010062 active site 156889010063 phosphorylation site [posttranslational modification] 156889010064 intermolecular recognition site; other site 156889010065 dimerization interface [polypeptide binding]; other site 156889010066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889010067 Zn2+ binding site [ion binding]; other site 156889010068 Mg2+ binding site [ion binding]; other site 156889010069 heat shock protein HtpX; Provisional; Region: PRK05457 156889010070 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 156889010071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 156889010072 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 156889010073 putative dimerization interface [polypeptide binding]; other site 156889010074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889010075 dimerization interface [polypeptide binding]; other site 156889010076 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889010077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889010078 dimer interface [polypeptide binding]; other site 156889010079 putative CheW interface [polypeptide binding]; other site 156889010080 Hemerythrin; Region: Hemerythrin; cd12107 156889010081 Fe binding site [ion binding]; other site 156889010082 spermidine synthase; Provisional; Region: PRK03612 156889010083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889010084 S-adenosylmethionine binding site [chemical binding]; other site 156889010085 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 156889010086 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 156889010087 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 156889010088 PspA/IM30 family; Region: PspA_IM30; pfam04012 156889010089 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 156889010090 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 156889010091 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 156889010092 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 156889010093 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 156889010094 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 156889010095 dimer interface [polypeptide binding]; other site 156889010096 putative PBP binding regions; other site 156889010097 ABC-ATPase subunit interface; other site 156889010098 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 156889010099 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 156889010100 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 156889010101 metal binding site 2 [ion binding]; metal-binding site 156889010102 putative DNA binding helix; other site 156889010103 metal binding site 1 [ion binding]; metal-binding site 156889010104 dimer interface [polypeptide binding]; other site 156889010105 structural Zn2+ binding site [ion binding]; other site 156889010106 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 156889010107 intersubunit interface [polypeptide binding]; other site 156889010108 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 156889010109 metal binding site [ion binding]; metal-binding site 156889010110 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 156889010111 Ca2+ binding site [ion binding]; other site 156889010112 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 156889010113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010114 active site 156889010115 phosphorylation site [posttranslational modification] 156889010116 intermolecular recognition site; other site 156889010117 dimerization interface [polypeptide binding]; other site 156889010118 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 156889010119 DNA binding site [nucleotide binding] 156889010120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889010121 dimerization interface [polypeptide binding]; other site 156889010122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010123 dimer interface [polypeptide binding]; other site 156889010124 phosphorylation site [posttranslational modification] 156889010125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010126 ATP binding site [chemical binding]; other site 156889010127 Mg2+ binding site [ion binding]; other site 156889010128 G-X-G motif; other site 156889010129 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 156889010130 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889010131 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 156889010132 Protein export membrane protein; Region: SecD_SecF; cl14618 156889010133 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889010134 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889010135 substrate binding pocket [chemical binding]; other site 156889010136 membrane-bound complex binding site; other site 156889010137 hinge residues; other site 156889010138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010139 PAS fold; Region: PAS_3; pfam08447 156889010140 putative active site [active] 156889010141 heme pocket [chemical binding]; other site 156889010142 PAS domain S-box; Region: sensory_box; TIGR00229 156889010143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010144 putative active site [active] 156889010145 heme pocket [chemical binding]; other site 156889010146 PAS domain S-box; Region: sensory_box; TIGR00229 156889010147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010148 putative active site [active] 156889010149 heme pocket [chemical binding]; other site 156889010150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889010151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010152 dimer interface [polypeptide binding]; other site 156889010153 phosphorylation site [posttranslational modification] 156889010154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010155 ATP binding site [chemical binding]; other site 156889010156 Mg2+ binding site [ion binding]; other site 156889010157 G-X-G motif; other site 156889010158 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010160 active site 156889010161 phosphorylation site [posttranslational modification] 156889010162 intermolecular recognition site; other site 156889010163 dimerization interface [polypeptide binding]; other site 156889010164 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 156889010165 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 156889010166 Methyltransferase domain; Region: Methyltransf_31; pfam13847 156889010167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889010168 S-adenosylmethionine binding site [chemical binding]; other site 156889010169 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 156889010170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 156889010171 active site 156889010172 phosphoglycolate phosphatase; Provisional; Region: PRK13222 156889010173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 156889010174 motif II; other site 156889010175 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 156889010176 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 156889010177 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 156889010178 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 156889010179 oxaloacetate decarboxylase; Provisional; Region: PRK14040 156889010180 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 156889010181 active site 156889010182 catalytic residues [active] 156889010183 metal binding site [ion binding]; metal-binding site 156889010184 homodimer binding site [polypeptide binding]; other site 156889010185 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 156889010186 carboxyltransferase (CT) interaction site; other site 156889010187 biotinylation site [posttranslational modification]; other site 156889010188 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 156889010189 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 156889010190 30S subunit binding site; other site 156889010191 Predicted permeases [General function prediction only]; Region: COG0701 156889010192 TIGR03943 family protein; Region: TIGR03943 156889010193 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 156889010194 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 156889010195 ligand binding site [chemical binding]; other site 156889010196 flexible hinge region; other site 156889010197 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 156889010198 putative switch regulator; other site 156889010199 non-specific DNA interactions [nucleotide binding]; other site 156889010200 DNA binding site [nucleotide binding] 156889010201 sequence specific DNA binding site [nucleotide binding]; other site 156889010202 putative cAMP binding site [chemical binding]; other site 156889010203 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 156889010204 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 156889010205 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889010206 substrate binding pocket [chemical binding]; other site 156889010207 membrane-bound complex binding site; other site 156889010208 hinge residues; other site 156889010209 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889010210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010211 dimer interface [polypeptide binding]; other site 156889010212 phosphorylation site [posttranslational modification] 156889010213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010214 ATP binding site [chemical binding]; other site 156889010215 Mg2+ binding site [ion binding]; other site 156889010216 G-X-G motif; other site 156889010217 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010219 active site 156889010220 phosphorylation site [posttranslational modification] 156889010221 intermolecular recognition site; other site 156889010222 dimerization interface [polypeptide binding]; other site 156889010223 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 156889010224 active site residue [active] 156889010225 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010227 active site 156889010228 phosphorylation site [posttranslational modification] 156889010229 intermolecular recognition site; other site 156889010230 dimerization interface [polypeptide binding]; other site 156889010231 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 156889010232 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 156889010233 Protein export membrane protein; Region: SecD_SecF; pfam02355 156889010234 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 156889010235 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 156889010236 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 156889010237 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 156889010238 HDOD domain; Region: HDOD; pfam08668 156889010239 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 156889010240 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 156889010241 Uncharacterized conserved protein [Function unknown]; Region: COG1262 156889010242 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 156889010243 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 156889010244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889010245 binding surface 156889010246 TPR motif; other site 156889010247 Caspase domain; Region: Peptidase_C14; pfam00656 156889010248 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 156889010249 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 156889010250 intersubunit interface [polypeptide binding]; other site 156889010251 active site 156889010252 zinc binding site [ion binding]; other site 156889010253 Na+ binding site [ion binding]; other site 156889010254 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889010255 Predicted ATPase [General function prediction only]; Region: COG4637 156889010256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889010257 Walker A/P-loop; other site 156889010258 ATP binding site [chemical binding]; other site 156889010259 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 156889010260 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 156889010261 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 156889010262 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889010263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889010264 metal binding site [ion binding]; metal-binding site 156889010265 active site 156889010266 I-site; other site 156889010267 EAL domain; Region: EAL; pfam00563 156889010268 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 156889010269 flagellin; Provisional; Region: PRK12802 156889010270 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 156889010271 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889010272 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889010273 substrate binding pocket [chemical binding]; other site 156889010274 membrane-bound complex binding site; other site 156889010275 hinge residues; other site 156889010276 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889010277 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889010278 substrate binding pocket [chemical binding]; other site 156889010279 membrane-bound complex binding site; other site 156889010280 hinge residues; other site 156889010281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010282 dimer interface [polypeptide binding]; other site 156889010283 phosphorylation site [posttranslational modification] 156889010284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010285 ATP binding site [chemical binding]; other site 156889010286 Mg2+ binding site [ion binding]; other site 156889010287 G-X-G motif; other site 156889010288 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010290 active site 156889010291 phosphorylation site [posttranslational modification] 156889010292 intermolecular recognition site; other site 156889010293 dimerization interface [polypeptide binding]; other site 156889010294 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889010295 putative binding surface; other site 156889010296 active site 156889010297 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010299 active site 156889010300 phosphorylation site [posttranslational modification] 156889010301 intermolecular recognition site; other site 156889010302 dimerization interface [polypeptide binding]; other site 156889010303 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 156889010304 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 156889010305 active site 156889010306 dimer interface [polypeptide binding]; other site 156889010307 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 156889010308 Ligand Binding Site [chemical binding]; other site 156889010309 Molecular Tunnel; other site 156889010310 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 156889010311 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 156889010312 putative active site [active] 156889010313 putative PHP Thumb interface [polypeptide binding]; other site 156889010314 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 156889010315 generic binding surface II; other site 156889010316 generic binding surface I; other site 156889010317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889010318 AAA domain; Region: AAA_23; pfam13476 156889010319 Walker A/P-loop; other site 156889010320 ATP binding site [chemical binding]; other site 156889010321 glutamate racemase; Provisional; Region: PRK00865 156889010322 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 156889010323 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 156889010324 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 156889010325 active site 156889010326 catalytic triad [active] 156889010327 oxyanion hole [active] 156889010328 PilZ domain; Region: PilZ; pfam07238 156889010329 Hemerythrin; Region: Hemerythrin; cd12107 156889010330 Fe binding site [ion binding]; other site 156889010331 fumarate hydratase; Provisional; Region: PRK15389 156889010332 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 156889010333 Fumarase C-terminus; Region: Fumerase_C; pfam05683 156889010334 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 156889010335 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 156889010336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889010337 dimerization interface [polypeptide binding]; other site 156889010338 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889010339 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889010340 dimer interface [polypeptide binding]; other site 156889010341 putative CheW interface [polypeptide binding]; other site 156889010342 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889010343 anti sigma factor interaction site; other site 156889010344 regulatory phosphorylation site [posttranslational modification]; other site 156889010345 PAS domain; Region: PAS_9; pfam13426 156889010346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010347 putative active site [active] 156889010348 heme pocket [chemical binding]; other site 156889010349 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889010350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010351 dimer interface [polypeptide binding]; other site 156889010352 phosphorylation site [posttranslational modification] 156889010353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010354 ATP binding site [chemical binding]; other site 156889010355 Mg2+ binding site [ion binding]; other site 156889010356 G-X-G motif; other site 156889010357 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010359 active site 156889010360 phosphorylation site [posttranslational modification] 156889010361 intermolecular recognition site; other site 156889010362 dimerization interface [polypeptide binding]; other site 156889010363 EamA-like transporter family; Region: EamA; cl17759 156889010364 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 156889010365 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 156889010366 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 156889010367 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889010368 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 156889010369 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 156889010370 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 156889010371 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 156889010372 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 156889010373 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 156889010374 P-loop; other site 156889010375 Magnesium ion binding site [ion binding]; other site 156889010376 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889010377 FecR protein; Region: FecR; pfam04773 156889010378 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 156889010379 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 156889010380 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 156889010381 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 156889010382 Ca2+ binding site [ion binding]; other site 156889010383 Cadherin repeat-like domain; Region: CA_like; cl15786 156889010384 Ca2+ binding site [ion binding]; other site 156889010385 Cadherin repeat-like domain; Region: CA_like; cl15786 156889010386 Cadherin repeat-like domain; Region: CA_like; cl15786 156889010387 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 156889010388 Ca2+ binding site [ion binding]; other site 156889010389 Cadherin repeat-like domain; Region: CA_like; cl15786 156889010390 Ca2+ binding site [ion binding]; other site 156889010391 Cadherin repeat-like domain; Region: CA_like; cl15786 156889010392 Ca2+ binding site [ion binding]; other site 156889010393 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 156889010394 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 156889010395 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 156889010396 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 156889010397 DNA polymerase I; Provisional; Region: PRK05755 156889010398 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 156889010399 active site 156889010400 metal binding site 1 [ion binding]; metal-binding site 156889010401 putative 5' ssDNA interaction site; other site 156889010402 metal binding site 3; metal-binding site 156889010403 metal binding site 2 [ion binding]; metal-binding site 156889010404 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 156889010405 putative DNA binding site [nucleotide binding]; other site 156889010406 putative metal binding site [ion binding]; other site 156889010407 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 156889010408 active site 156889010409 catalytic site [active] 156889010410 substrate binding site [chemical binding]; other site 156889010411 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 156889010412 active site 156889010413 DNA binding site [nucleotide binding] 156889010414 catalytic site [active] 156889010415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 156889010416 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 156889010417 putative substrate translocation pore; other site 156889010418 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 156889010419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889010420 Walker A/P-loop; other site 156889010421 ATP binding site [chemical binding]; other site 156889010422 Q-loop/lid; other site 156889010423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889010424 ABC transporter signature motif; other site 156889010425 Walker B; other site 156889010426 D-loop; other site 156889010427 H-loop/switch region; other site 156889010428 PBP superfamily domain; Region: PBP_like_2; cl17296 156889010429 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 156889010430 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 156889010431 active site 156889010432 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 156889010433 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 156889010434 Ligand binding site; other site 156889010435 Putative Catalytic site; other site 156889010436 DXD motif; other site 156889010437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889010438 binding surface 156889010439 TPR motif; other site 156889010440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889010441 binding surface 156889010442 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889010443 TPR motif; other site 156889010444 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889010445 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 156889010446 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 156889010447 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 156889010448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 156889010449 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 156889010450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010451 active site 156889010452 phosphorylation site [posttranslational modification] 156889010453 intermolecular recognition site; other site 156889010454 dimerization interface [polypeptide binding]; other site 156889010455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010456 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010457 active site 156889010458 phosphorylation site [posttranslational modification] 156889010459 intermolecular recognition site; other site 156889010460 dimerization interface [polypeptide binding]; other site 156889010461 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889010462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010463 putative active site [active] 156889010464 heme pocket [chemical binding]; other site 156889010465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010466 dimer interface [polypeptide binding]; other site 156889010467 phosphorylation site [posttranslational modification] 156889010468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010469 ATP binding site [chemical binding]; other site 156889010470 Mg2+ binding site [ion binding]; other site 156889010471 G-X-G motif; other site 156889010472 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010474 active site 156889010475 phosphorylation site [posttranslational modification] 156889010476 intermolecular recognition site; other site 156889010477 dimerization interface [polypeptide binding]; other site 156889010478 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010480 active site 156889010481 phosphorylation site [posttranslational modification] 156889010482 intermolecular recognition site; other site 156889010483 dimerization interface [polypeptide binding]; other site 156889010484 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889010485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010486 active site 156889010487 phosphorylation site [posttranslational modification] 156889010488 intermolecular recognition site; other site 156889010489 dimerization interface [polypeptide binding]; other site 156889010490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010491 phosphorylation site [posttranslational modification] 156889010492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010493 ATP binding site [chemical binding]; other site 156889010494 Mg2+ binding site [ion binding]; other site 156889010495 G-X-G motif; other site 156889010496 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010498 active site 156889010499 phosphorylation site [posttranslational modification] 156889010500 intermolecular recognition site; other site 156889010501 dimerization interface [polypeptide binding]; other site 156889010502 TM1410 hypothetical-related protein; Region: DUF297; cl00997 156889010503 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889010504 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 156889010505 putative ADP-binding pocket [chemical binding]; other site 156889010506 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 156889010507 NADPH bind site [chemical binding]; other site 156889010508 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 156889010509 putative FMN binding site [chemical binding]; other site 156889010510 NADPH bind site [chemical binding]; other site 156889010511 hypothetical protein; Provisional; Region: PRK08960 156889010512 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 156889010513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889010514 homodimer interface [polypeptide binding]; other site 156889010515 catalytic residue [active] 156889010516 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 156889010517 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 156889010518 Probable Catalytic site; other site 156889010519 metal-binding site 156889010520 cobalamin synthase; Reviewed; Region: cobS; PRK00235 156889010521 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 156889010522 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 156889010523 putative dimer interface [polypeptide binding]; other site 156889010524 active site pocket [active] 156889010525 putative cataytic base [active] 156889010526 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 156889010527 Rubrerythrin [Energy production and conversion]; Region: COG1592 156889010528 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 156889010529 binuclear metal center [ion binding]; other site 156889010530 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 156889010531 iron binding site [ion binding]; other site 156889010532 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 156889010533 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 156889010534 active site 156889010535 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 156889010536 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 156889010537 substrate binding site [chemical binding]; other site 156889010538 ATP binding site [chemical binding]; other site 156889010539 PilZ domain; Region: PilZ; pfam07238 156889010540 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 156889010541 thiamine phosphate binding site [chemical binding]; other site 156889010542 active site 156889010543 pyrophosphate binding site [ion binding]; other site 156889010544 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 156889010545 Domain of unknown function (DUF955); Region: DUF955; pfam06114 156889010546 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 156889010547 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 156889010548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889010549 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 156889010550 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889010551 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889010552 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 156889010553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 156889010554 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 156889010555 FAD binding domain; Region: FAD_binding_4; pfam01565 156889010556 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 156889010557 BON domain; Region: BON; pfam04972 156889010558 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 156889010559 BON domain; Region: BON; pfam04972 156889010560 hypothetical protein; Reviewed; Region: PRK12497 156889010561 Predicted methyltransferases [General function prediction only]; Region: COG0313 156889010562 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 156889010563 putative homodimer interface [polypeptide binding]; other site 156889010564 putative SAM binding site [chemical binding]; other site 156889010565 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 156889010566 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 156889010567 putative ligand binding site [chemical binding]; other site 156889010568 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 156889010569 catalytic triad [active] 156889010570 AAA domain; Region: AAA_31; pfam13614 156889010571 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 156889010572 P-loop; other site 156889010573 Magnesium ion binding site [ion binding]; other site 156889010574 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 156889010575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889010576 TPR motif; other site 156889010577 binding surface 156889010578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889010579 TPR motif; other site 156889010580 binding surface 156889010581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889010582 TPR motif; other site 156889010583 binding surface 156889010584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889010585 binding surface 156889010586 TPR motif; other site 156889010587 TPR repeat; Region: TPR_11; pfam13414 156889010588 Short C-terminal domain; Region: SHOCT; pfam09851 156889010589 ABC-2 type transporter; Region: ABC2_membrane; cl17235 156889010590 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 156889010591 nodulation ABC transporter NodI; Provisional; Region: PRK13537 156889010592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889010593 Walker A/P-loop; other site 156889010594 ATP binding site [chemical binding]; other site 156889010595 Q-loop/lid; other site 156889010596 ABC transporter signature motif; other site 156889010597 Walker B; other site 156889010598 D-loop; other site 156889010599 H-loop/switch region; other site 156889010600 Uncharacterized conserved protein [Function unknown]; Region: COG0062 156889010601 putative carbohydrate kinase; Provisional; Region: PRK10565 156889010602 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 156889010603 putative substrate binding site [chemical binding]; other site 156889010604 putative ATP binding site [chemical binding]; other site 156889010605 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889010606 dimer interface [polypeptide binding]; other site 156889010607 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 156889010608 putative CheW interface [polypeptide binding]; other site 156889010609 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 156889010610 putative active site [active] 156889010611 putative catalytic site [active] 156889010612 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 156889010613 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889010614 putative homodimer interface [polypeptide binding]; other site 156889010615 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 156889010616 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 156889010617 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 156889010618 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 156889010619 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 156889010620 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 156889010621 NADP binding site [chemical binding]; other site 156889010622 active site 156889010623 putative substrate binding site [chemical binding]; other site 156889010624 Poly(A) polymerase; Provisional; Region: PTZ00418 156889010625 tellurium resistance terB-like protein; Region: terB_like; cd07177 156889010626 metal binding site [ion binding]; metal-binding site 156889010627 phosphodiesterase; Provisional; Region: PRK12704 156889010628 Transposase; Region: HTH_Tnp_1; cl17663 156889010629 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 156889010630 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889010631 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 156889010632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 156889010633 ATP binding site [chemical binding]; other site 156889010634 putative Mg++ binding site [ion binding]; other site 156889010635 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 156889010636 SEC-C motif; Region: SEC-C; pfam02810 156889010637 Sporulation related domain; Region: SPOR; pfam05036 156889010638 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 156889010639 Protein of unknown function (DUF721); Region: DUF721; pfam05258 156889010640 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 156889010641 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 156889010642 homotetramer interface [polypeptide binding]; other site 156889010643 ligand binding site [chemical binding]; other site 156889010644 catalytic site [active] 156889010645 NAD binding site [chemical binding]; other site 156889010646 S-adenosylmethionine synthetase; Validated; Region: PRK05250 156889010647 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 156889010648 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 156889010649 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 156889010650 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 156889010651 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 156889010652 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 156889010653 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 156889010654 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 156889010655 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 156889010656 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 156889010657 Walker A/P-loop; other site 156889010658 ATP binding site [chemical binding]; other site 156889010659 Q-loop/lid; other site 156889010660 ABC transporter signature motif; other site 156889010661 Walker B; other site 156889010662 D-loop; other site 156889010663 H-loop/switch region; other site 156889010664 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 156889010665 OstA-like protein; Region: OstA; pfam03968 156889010666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 156889010667 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 156889010668 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 156889010669 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 156889010670 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 156889010671 putative active site [active] 156889010672 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 156889010673 FOG: CBS domain [General function prediction only]; Region: COG0517 156889010674 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 156889010675 FOG: CBS domain [General function prediction only]; Region: COG0517 156889010676 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 156889010677 FOG: CBS domain [General function prediction only]; Region: COG0517 156889010678 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 156889010679 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 156889010680 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 156889010681 PBP superfamily domain; Region: PBP_like; cl17867 156889010682 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 156889010683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010684 dimer interface [polypeptide binding]; other site 156889010685 phosphorylation site [posttranslational modification] 156889010686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010687 ATP binding site [chemical binding]; other site 156889010688 Mg2+ binding site [ion binding]; other site 156889010689 G-X-G motif; other site 156889010690 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010692 active site 156889010693 phosphorylation site [posttranslational modification] 156889010694 intermolecular recognition site; other site 156889010695 dimerization interface [polypeptide binding]; other site 156889010696 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 156889010697 dimerization interface [polypeptide binding]; other site 156889010698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010699 PAS domain; Region: PAS_9; pfam13426 156889010700 putative active site [active] 156889010701 heme pocket [chemical binding]; other site 156889010702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010703 dimer interface [polypeptide binding]; other site 156889010704 phosphorylation site [posttranslational modification] 156889010705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010706 ATP binding site [chemical binding]; other site 156889010707 Mg2+ binding site [ion binding]; other site 156889010708 G-X-G motif; other site 156889010709 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010711 active site 156889010712 phosphorylation site [posttranslational modification] 156889010713 intermolecular recognition site; other site 156889010714 dimerization interface [polypeptide binding]; other site 156889010715 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889010716 putative binding surface; other site 156889010717 active site 156889010718 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 156889010719 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 156889010720 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 156889010721 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 156889010722 active site 156889010723 (T/H)XGH motif; other site 156889010724 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 156889010725 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 156889010726 putative catalytic cysteine [active] 156889010727 gamma-glutamyl kinase; Provisional; Region: PRK05429 156889010728 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 156889010729 nucleotide binding site [chemical binding]; other site 156889010730 homotetrameric interface [polypeptide binding]; other site 156889010731 putative phosphate binding site [ion binding]; other site 156889010732 putative allosteric binding site; other site 156889010733 PUA domain; Region: PUA; pfam01472 156889010734 GTPase CgtA; Reviewed; Region: obgE; PRK12299 156889010735 GTP1/OBG; Region: GTP1_OBG; pfam01018 156889010736 Obg GTPase; Region: Obg; cd01898 156889010737 G1 box; other site 156889010738 GTP/Mg2+ binding site [chemical binding]; other site 156889010739 Switch I region; other site 156889010740 G2 box; other site 156889010741 G3 box; other site 156889010742 Switch II region; other site 156889010743 G4 box; other site 156889010744 G5 box; other site 156889010745 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 156889010746 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 156889010747 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 156889010748 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 156889010749 Maf-like protein; Region: Maf; pfam02545 156889010750 active site 156889010751 dimer interface [polypeptide binding]; other site 156889010752 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 156889010753 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 156889010754 substrate binding pocket [chemical binding]; other site 156889010755 chain length determination region; other site 156889010756 substrate-Mg2+ binding site; other site 156889010757 catalytic residues [active] 156889010758 aspartate-rich region 1; other site 156889010759 active site lid residues [active] 156889010760 aspartate-rich region 2; other site 156889010761 CHASE domain; Region: CHASE; cl01369 156889010762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889010763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010764 dimer interface [polypeptide binding]; other site 156889010765 phosphorylation site [posttranslational modification] 156889010766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010767 ATP binding site [chemical binding]; other site 156889010768 Mg2+ binding site [ion binding]; other site 156889010769 G-X-G motif; other site 156889010770 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010772 active site 156889010773 phosphorylation site [posttranslational modification] 156889010774 intermolecular recognition site; other site 156889010775 dimerization interface [polypeptide binding]; other site 156889010776 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 156889010777 Hemerythrin; Region: Hemerythrin; cd12107 156889010778 Fe binding site [ion binding]; other site 156889010779 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 156889010780 Catalytic domain of Protein Kinases; Region: PKc; cd00180 156889010781 active site 156889010782 ATP binding site [chemical binding]; other site 156889010783 substrate binding site [chemical binding]; other site 156889010784 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 156889010785 substrate binding site [chemical binding]; other site 156889010786 activation loop (A-loop); other site 156889010787 activation loop (A-loop); other site 156889010788 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889010789 Sel1-like repeats; Region: SEL1; smart00671 156889010790 Protein kinase domain; Region: Pkinase; pfam00069 156889010791 Catalytic domain of Protein Kinases; Region: PKc; cd00180 156889010792 active site 156889010793 ATP binding site [chemical binding]; other site 156889010794 substrate binding site [chemical binding]; other site 156889010795 activation loop (A-loop); other site 156889010796 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889010797 Sel1-like repeats; Region: SEL1; smart00671 156889010798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889010799 binding surface 156889010800 TPR motif; other site 156889010801 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 156889010802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889010803 binding surface 156889010804 TPR motif; other site 156889010805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 156889010806 putative substrate translocation pore; other site 156889010807 Protein of unknown function DUF45; Region: DUF45; pfam01863 156889010808 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 156889010809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889010810 non-specific DNA binding site [nucleotide binding]; other site 156889010811 salt bridge; other site 156889010812 sequence-specific DNA binding site [nucleotide binding]; other site 156889010813 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 156889010814 Catalytic site [active] 156889010815 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 156889010816 PAS domain S-box; Region: sensory_box; TIGR00229 156889010817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010818 putative active site [active] 156889010819 heme pocket [chemical binding]; other site 156889010820 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010821 PAS fold; Region: PAS_3; pfam08447 156889010822 putative active site [active] 156889010823 heme pocket [chemical binding]; other site 156889010824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889010825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010826 dimer interface [polypeptide binding]; other site 156889010827 phosphorylation site [posttranslational modification] 156889010828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010829 ATP binding site [chemical binding]; other site 156889010830 Mg2+ binding site [ion binding]; other site 156889010831 G-X-G motif; other site 156889010832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010833 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010834 active site 156889010835 phosphorylation site [posttranslational modification] 156889010836 intermolecular recognition site; other site 156889010837 dimerization interface [polypeptide binding]; other site 156889010838 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889010839 putative binding surface; other site 156889010840 active site 156889010841 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 156889010842 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010844 active site 156889010845 phosphorylation site [posttranslational modification] 156889010846 intermolecular recognition site; other site 156889010847 dimerization interface [polypeptide binding]; other site 156889010848 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 156889010849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 156889010850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 156889010851 DNA binding residues [nucleotide binding] 156889010852 Paraquat-inducible protein A; Region: PqiA; pfam04403 156889010853 Paraquat-inducible protein A; Region: PqiA; pfam04403 156889010854 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 156889010855 mce related protein; Region: MCE; pfam02470 156889010856 mce related protein; Region: MCE; pfam02470 156889010857 mce related protein; Region: MCE; pfam02470 156889010858 Protein of unknown function (DUF330); Region: DUF330; pfam03886 156889010859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 156889010860 Major Facilitator Superfamily; Region: MFS_1; pfam07690 156889010861 putative substrate translocation pore; other site 156889010862 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 156889010863 DNA polymerase III, delta subunit; Region: holA; TIGR01128 156889010864 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 156889010865 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 156889010866 AAA domain; Region: AAA_30; pfam13604 156889010867 Family description; Region: UvrD_C_2; pfam13538 156889010868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010869 dimer interface [polypeptide binding]; other site 156889010870 phosphorylation site [posttranslational modification] 156889010871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010872 ATP binding site [chemical binding]; other site 156889010873 Mg2+ binding site [ion binding]; other site 156889010874 G-X-G motif; other site 156889010875 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 156889010876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010877 active site 156889010878 phosphorylation site [posttranslational modification] 156889010879 intermolecular recognition site; other site 156889010880 dimerization interface [polypeptide binding]; other site 156889010881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 156889010882 DNA binding site [nucleotide binding] 156889010883 Outer membrane efflux protein; Region: OEP; pfam02321 156889010884 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 156889010885 HlyD family secretion protein; Region: HlyD_3; pfam13437 156889010886 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 156889010887 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 156889010888 NMT1/THI5 like; Region: NMT1; pfam09084 156889010889 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 156889010890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889010891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010892 dimer interface [polypeptide binding]; other site 156889010893 phosphorylation site [posttranslational modification] 156889010894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010895 ATP binding site [chemical binding]; other site 156889010896 Mg2+ binding site [ion binding]; other site 156889010897 G-X-G motif; other site 156889010898 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 156889010899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010900 active site 156889010901 phosphorylation site [posttranslational modification] 156889010902 intermolecular recognition site; other site 156889010903 dimerization interface [polypeptide binding]; other site 156889010904 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 156889010905 DNA binding site [nucleotide binding] 156889010906 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 156889010907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010908 active site 156889010909 phosphorylation site [posttranslational modification] 156889010910 intermolecular recognition site; other site 156889010911 dimerization interface [polypeptide binding]; other site 156889010912 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 156889010913 dimerization interface [polypeptide binding]; other site 156889010914 DNA binding residues [nucleotide binding] 156889010915 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 156889010916 CheB methylesterase; Region: CheB_methylest; pfam01339 156889010917 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 156889010918 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 156889010919 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 156889010920 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 156889010921 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 156889010922 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 156889010923 PAS domain; Region: PAS_10; pfam13596 156889010924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010925 PAS fold; Region: PAS_3; pfam08447 156889010926 putative active site [active] 156889010927 heme pocket [chemical binding]; other site 156889010928 PAS domain S-box; Region: sensory_box; TIGR00229 156889010929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 156889010930 putative active site [active] 156889010931 heme pocket [chemical binding]; other site 156889010932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010933 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889010934 putative active site [active] 156889010935 heme pocket [chemical binding]; other site 156889010936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010937 dimer interface [polypeptide binding]; other site 156889010938 phosphorylation site [posttranslational modification] 156889010939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010940 ATP binding site [chemical binding]; other site 156889010941 Mg2+ binding site [ion binding]; other site 156889010942 G-X-G motif; other site 156889010943 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010945 active site 156889010946 phosphorylation site [posttranslational modification] 156889010947 intermolecular recognition site; other site 156889010948 dimerization interface [polypeptide binding]; other site 156889010949 PAS fold; Region: PAS; pfam00989 156889010950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010951 putative active site [active] 156889010952 heme pocket [chemical binding]; other site 156889010953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010954 PAS domain; Region: PAS_9; pfam13426 156889010955 putative active site [active] 156889010956 heme pocket [chemical binding]; other site 156889010957 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889010958 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889010959 metal binding site [ion binding]; metal-binding site 156889010960 active site 156889010961 I-site; other site 156889010962 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 156889010963 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010965 active site 156889010966 phosphorylation site [posttranslational modification] 156889010967 intermolecular recognition site; other site 156889010968 dimerization interface [polypeptide binding]; other site 156889010969 PAS domain; Region: PAS_9; pfam13426 156889010970 Protein of unknown function (DUF525); Region: DUF525; cl01119 156889010971 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889010972 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889010973 putative active site [active] 156889010974 heme pocket [chemical binding]; other site 156889010975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889010976 dimer interface [polypeptide binding]; other site 156889010977 phosphorylation site [posttranslational modification] 156889010978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889010979 ATP binding site [chemical binding]; other site 156889010980 Mg2+ binding site [ion binding]; other site 156889010981 G-X-G motif; other site 156889010982 Response regulator receiver domain; Region: Response_reg; pfam00072 156889010983 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889010984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889010985 active site 156889010986 phosphorylation site [posttranslational modification] 156889010987 intermolecular recognition site; other site 156889010988 dimerization interface [polypeptide binding]; other site 156889010989 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 156889010990 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 156889010991 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 156889010992 dimer interface [polypeptide binding]; other site 156889010993 active site 156889010994 metal binding site [ion binding]; metal-binding site 156889010995 glutathione binding site [chemical binding]; other site 156889010996 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889010997 dimerization interface [polypeptide binding]; other site 156889010998 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889010999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889011000 putative active site [active] 156889011001 heme pocket [chemical binding]; other site 156889011002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889011003 dimer interface [polypeptide binding]; other site 156889011004 phosphorylation site [posttranslational modification] 156889011005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889011006 ATP binding site [chemical binding]; other site 156889011007 Mg2+ binding site [ion binding]; other site 156889011008 G-X-G motif; other site 156889011009 Response regulator receiver domain; Region: Response_reg; pfam00072 156889011010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011011 active site 156889011012 phosphorylation site [posttranslational modification] 156889011013 intermolecular recognition site; other site 156889011014 dimerization interface [polypeptide binding]; other site 156889011015 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889011016 putative binding surface; other site 156889011017 active site 156889011018 PAS domain S-box; Region: sensory_box; TIGR00229 156889011019 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889011020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889011021 putative active site [active] 156889011022 heme pocket [chemical binding]; other site 156889011023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889011024 dimer interface [polypeptide binding]; other site 156889011025 phosphorylation site [posttranslational modification] 156889011026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889011027 ATP binding site [chemical binding]; other site 156889011028 Mg2+ binding site [ion binding]; other site 156889011029 G-X-G motif; other site 156889011030 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889011031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011032 active site 156889011033 phosphorylation site [posttranslational modification] 156889011034 intermolecular recognition site; other site 156889011035 dimerization interface [polypeptide binding]; other site 156889011036 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 156889011037 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 156889011038 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 156889011039 Fe-S cluster binding site [ion binding]; other site 156889011040 active site 156889011041 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889011042 FeS/SAM binding site; other site 156889011043 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 156889011044 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 156889011045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011046 active site 156889011047 phosphorylation site [posttranslational modification] 156889011048 intermolecular recognition site; other site 156889011049 dimerization interface [polypeptide binding]; other site 156889011050 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889011051 Zn2+ binding site [ion binding]; other site 156889011052 Mg2+ binding site [ion binding]; other site 156889011053 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889011054 substrate binding pocket [chemical binding]; other site 156889011055 membrane-bound complex binding site; other site 156889011056 hinge residues; other site 156889011057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889011058 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889011059 substrate binding pocket [chemical binding]; other site 156889011060 membrane-bound complex binding site; other site 156889011061 hinge residues; other site 156889011062 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 156889011063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 156889011064 substrate binding pocket [chemical binding]; other site 156889011065 membrane-bound complex binding site; other site 156889011066 PAS fold; Region: PAS_7; pfam12860 156889011067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889011068 PAS fold; Region: PAS_3; pfam08447 156889011069 putative active site [active] 156889011070 heme pocket [chemical binding]; other site 156889011071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889011072 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889011073 putative active site [active] 156889011074 heme pocket [chemical binding]; other site 156889011075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889011076 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 156889011077 putative active site [active] 156889011078 heme pocket [chemical binding]; other site 156889011079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889011080 dimer interface [polypeptide binding]; other site 156889011081 phosphorylation site [posttranslational modification] 156889011082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889011083 ATP binding site [chemical binding]; other site 156889011084 Mg2+ binding site [ion binding]; other site 156889011085 G-X-G motif; other site 156889011086 Response regulator receiver domain; Region: Response_reg; pfam00072 156889011087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011088 active site 156889011089 phosphorylation site [posttranslational modification] 156889011090 intermolecular recognition site; other site 156889011091 dimerization interface [polypeptide binding]; other site 156889011092 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889011093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011094 active site 156889011095 phosphorylation site [posttranslational modification] 156889011096 intermolecular recognition site; other site 156889011097 dimerization interface [polypeptide binding]; other site 156889011098 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 156889011099 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 156889011100 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 156889011101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889011102 Walker A/P-loop; other site 156889011103 ATP binding site [chemical binding]; other site 156889011104 Q-loop/lid; other site 156889011105 ABC transporter signature motif; other site 156889011106 Walker B; other site 156889011107 D-loop; other site 156889011108 H-loop/switch region; other site 156889011109 Predicted membrane protein [Function unknown]; Region: COG3431 156889011110 Sporulation related domain; Region: SPOR; pfam05036 156889011111 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 156889011112 CPxP motif; other site 156889011113 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 156889011114 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 156889011115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889011116 dimer interface [polypeptide binding]; other site 156889011117 phosphorylation site [posttranslational modification] 156889011118 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 156889011119 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 156889011120 dimer interface [polypeptide binding]; other site 156889011121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889011122 catalytic residue [active] 156889011123 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 156889011124 ATP binding site [chemical binding]; other site 156889011125 substrate interface [chemical binding]; other site 156889011126 Rrf2 family protein; Region: rrf2_super; TIGR00738 156889011127 Transcriptional regulator; Region: Rrf2; pfam02082 156889011128 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 156889011129 trimer interface [polypeptide binding]; other site 156889011130 active site 156889011131 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 156889011132 Flavoprotein; Region: Flavoprotein; pfam02441 156889011133 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 156889011134 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 156889011135 preprotein translocase subunit SecB; Validated; Region: PRK05751 156889011136 SecA binding site; other site 156889011137 Preprotein binding site; other site 156889011138 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 156889011139 DEAD-like helicases superfamily; Region: DEXDc; smart00487 156889011140 ATP binding site [chemical binding]; other site 156889011141 Mg++ binding site [ion binding]; other site 156889011142 motif III; other site 156889011143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 156889011144 nucleotide binding region [chemical binding]; other site 156889011145 ATP-binding site [chemical binding]; other site 156889011146 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 156889011147 integral membrane protein MviN; Region: mviN; TIGR01695 156889011148 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 156889011149 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 156889011150 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 156889011151 heterodimer interface [polypeptide binding]; other site 156889011152 active site 156889011153 FMN binding site [chemical binding]; other site 156889011154 homodimer interface [polypeptide binding]; other site 156889011155 substrate binding site [chemical binding]; other site 156889011156 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 156889011157 Catalytic site; other site 156889011158 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 156889011159 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 156889011160 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 156889011161 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889011162 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889011163 metal binding site [ion binding]; metal-binding site 156889011164 active site 156889011165 I-site; other site 156889011166 Methyltransferase domain; Region: Methyltransf_23; pfam13489 156889011167 Methyltransferase domain; Region: Methyltransf_12; pfam08242 156889011168 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 156889011169 dimer interface [polypeptide binding]; other site 156889011170 substrate binding site [chemical binding]; other site 156889011171 metal binding sites [ion binding]; metal-binding site 156889011172 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 156889011173 phosphoglucomutase; Region: PLN02307 156889011174 substrate binding site [chemical binding]; other site 156889011175 dimer interface [polypeptide binding]; other site 156889011176 active site 156889011177 metal binding site [ion binding]; metal-binding site 156889011178 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 156889011179 putative cation:proton antiport protein; Provisional; Region: PRK10669 156889011180 TrkA-N domain; Region: TrkA_N; pfam02254 156889011181 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 156889011182 homodimer interface [polypeptide binding]; other site 156889011183 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 156889011184 active site pocket [active] 156889011185 Cation transport protein; Region: TrkH; cl17365 156889011186 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 156889011187 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 156889011188 TrkA-N domain; Region: TrkA_N; pfam02254 156889011189 TrkA-C domain; Region: TrkA_C; pfam02080 156889011190 TrkA-N domain; Region: TrkA_N; pfam02254 156889011191 TrkA-C domain; Region: TrkA_C; pfam02080 156889011192 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 156889011193 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889011194 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 156889011195 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889011196 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 156889011197 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 156889011198 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 156889011199 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 156889011200 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889011201 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 156889011202 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 156889011203 Response regulator receiver domain; Region: Response_reg; pfam00072 156889011204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011205 active site 156889011206 phosphorylation site [posttranslational modification] 156889011207 intermolecular recognition site; other site 156889011208 dimerization interface [polypeptide binding]; other site 156889011209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 156889011210 dimerization interface [polypeptide binding]; other site 156889011211 putative DNA binding site [nucleotide binding]; other site 156889011212 putative Zn2+ binding site [ion binding]; other site 156889011213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 156889011214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889011215 dimer interface [polypeptide binding]; other site 156889011216 phosphorylation site [posttranslational modification] 156889011217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889011218 ATP binding site [chemical binding]; other site 156889011219 Mg2+ binding site [ion binding]; other site 156889011220 G-X-G motif; other site 156889011221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 156889011222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 156889011223 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 156889011224 substrate binding pocket [chemical binding]; other site 156889011225 dimerization interface [polypeptide binding]; other site 156889011226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 156889011227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 156889011228 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 156889011229 substrate binding pocket [chemical binding]; other site 156889011230 dimerization interface [polypeptide binding]; other site 156889011231 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 156889011232 N-acetyl-D-glucosamine binding site [chemical binding]; other site 156889011233 catalytic residue [active] 156889011234 CHAT domain; Region: CHAT; pfam12770 156889011235 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 156889011236 Intracellular septation protein A; Region: IspA; pfam04279 156889011237 Methyltransferase domain; Region: Methyltransf_24; pfam13578 156889011238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 156889011239 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 156889011240 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 156889011241 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 156889011242 glutaminase active site [active] 156889011243 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 156889011244 dimer interface [polypeptide binding]; other site 156889011245 active site 156889011246 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 156889011247 dimer interface [polypeptide binding]; other site 156889011248 active site 156889011249 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 156889011250 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 156889011251 Substrate binding site; other site 156889011252 Mg++ binding site; other site 156889011253 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 156889011254 active site 156889011255 substrate binding site [chemical binding]; other site 156889011256 CoA binding site [chemical binding]; other site 156889011257 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 156889011258 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 156889011259 gamma subunit interface [polypeptide binding]; other site 156889011260 epsilon subunit interface [polypeptide binding]; other site 156889011261 LBP interface [polypeptide binding]; other site 156889011262 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 156889011263 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 156889011264 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 156889011265 alpha subunit interaction interface [polypeptide binding]; other site 156889011266 Walker A motif; other site 156889011267 ATP binding site [chemical binding]; other site 156889011268 Walker B motif; other site 156889011269 inhibitor binding site; inhibition site 156889011270 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 156889011271 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 156889011272 core domain interface [polypeptide binding]; other site 156889011273 delta subunit interface [polypeptide binding]; other site 156889011274 epsilon subunit interface [polypeptide binding]; other site 156889011275 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 156889011276 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 156889011277 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 156889011278 beta subunit interaction interface [polypeptide binding]; other site 156889011279 Walker A motif; other site 156889011280 ATP binding site [chemical binding]; other site 156889011281 Walker B motif; other site 156889011282 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 156889011283 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 156889011284 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 156889011285 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 156889011286 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 156889011287 AIR carboxylase; Region: AIRC; pfam00731 156889011288 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 156889011289 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 156889011290 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 156889011291 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 156889011292 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889011293 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 156889011294 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 156889011295 purine monophosphate binding site [chemical binding]; other site 156889011296 dimer interface [polypeptide binding]; other site 156889011297 putative catalytic residues [active] 156889011298 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 156889011299 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 156889011300 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 156889011301 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 156889011302 Domain of unknown function DUF20; Region: UPF0118; pfam01594 156889011303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 156889011304 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 156889011305 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 156889011306 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 156889011307 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 156889011308 dihydrodipicolinate synthase; Region: dapA; TIGR00674 156889011309 dimer interface [polypeptide binding]; other site 156889011310 active site 156889011311 catalytic residue [active] 156889011312 Cytochrome c; Region: Cytochrom_C; cl11414 156889011313 Cytochrome c; Region: Cytochrom_C; cl11414 156889011314 Cytochrome c; Region: Cytochrom_C; cl11414 156889011315 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 156889011316 SmpB-tmRNA interface; other site 156889011317 FOG: WD40 repeat [General function prediction only]; Region: COG2319 156889011318 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 156889011319 structural tetrad; other site 156889011320 WD40 repeats; Region: WD40; smart00320 156889011321 Autotransporter beta-domain; Region: Autotransporter; smart00869 156889011322 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 156889011323 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 156889011324 TPP-binding site [chemical binding]; other site 156889011325 dimer interface [polypeptide binding]; other site 156889011326 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 156889011327 PYR/PP interface [polypeptide binding]; other site 156889011328 dimer interface [polypeptide binding]; other site 156889011329 TPP binding site [chemical binding]; other site 156889011330 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 156889011331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 156889011332 FeS/SAM binding site; other site 156889011333 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 156889011334 short chain dehydrogenase; Provisional; Region: PRK05993 156889011335 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 156889011336 NADP binding site [chemical binding]; other site 156889011337 active site 156889011338 steroid binding site; other site 156889011339 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 156889011340 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 156889011341 Cl- selectivity filter; other site 156889011342 Cl- binding residues [ion binding]; other site 156889011343 pore gating glutamate residue; other site 156889011344 dimer interface [polypeptide binding]; other site 156889011345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 156889011346 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 156889011347 Part of AAA domain; Region: AAA_19; pfam13245 156889011348 Family description; Region: UvrD_C_2; pfam13538 156889011349 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 156889011350 Glucose inhibited division protein A; Region: GIDA; pfam01134 156889011351 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 156889011352 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 156889011353 active site 156889011354 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 156889011355 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 156889011356 conserved cys residue [active] 156889011357 TSCPD domain; Region: TSCPD; pfam12637 156889011358 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 156889011359 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 156889011360 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 156889011361 active site 156889011362 dimer interface [polypeptide binding]; other site 156889011363 effector binding site; other site 156889011364 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 156889011365 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 156889011366 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 156889011367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889011368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 156889011369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 156889011370 SCP-2 sterol transfer family; Region: SCP2; pfam02036 156889011371 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 156889011372 ABC1 family; Region: ABC1; cl17513 156889011373 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 156889011374 active site 156889011375 catalytic residues [active] 156889011376 metal binding site [ion binding]; metal-binding site 156889011377 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 156889011378 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 156889011379 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 156889011380 Sporulation related domain; Region: SPOR; pfam05036 156889011381 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 156889011382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889011383 Walker A/P-loop; other site 156889011384 ATP binding site [chemical binding]; other site 156889011385 Q-loop/lid; other site 156889011386 ABC transporter signature motif; other site 156889011387 Walker B; other site 156889011388 D-loop; other site 156889011389 H-loop/switch region; other site 156889011390 CcmB protein; Region: CcmB; cl17444 156889011391 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 156889011392 CcmE; Region: CcmE; pfam03100 156889011393 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 156889011394 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 156889011395 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 156889011396 catalytic residues [active] 156889011397 central insert; other site 156889011398 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 156889011399 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 156889011400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889011401 S-adenosylmethionine binding site [chemical binding]; other site 156889011402 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 156889011403 Peptidase family M23; Region: Peptidase_M23; pfam01551 156889011404 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889011405 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889011406 metal binding site [ion binding]; metal-binding site 156889011407 active site 156889011408 I-site; other site 156889011409 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 156889011410 NodB motif; other site 156889011411 putative active site [active] 156889011412 putative catalytic site [active] 156889011413 Zn binding site [ion binding]; other site 156889011414 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 156889011415 C-terminal peptidase (prc); Region: prc; TIGR00225 156889011416 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 156889011417 protein binding site [polypeptide binding]; other site 156889011418 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 156889011419 Catalytic dyad [active] 156889011420 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 156889011421 Peptidase family M23; Region: Peptidase_M23; pfam01551 156889011422 phosphoglyceromutase; Provisional; Region: PRK05434 156889011423 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 156889011424 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 156889011425 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 156889011426 transmembrane helices; other site 156889011427 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 156889011428 TrkA-C domain; Region: TrkA_C; pfam02080 156889011429 TrkA-C domain; Region: TrkA_C; pfam02080 156889011430 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 156889011431 Fic family protein [Function unknown]; Region: COG3177 156889011432 Fic/DOC family; Region: Fic; pfam02661 156889011433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 156889011434 putative DNA binding site [nucleotide binding]; other site 156889011435 putative Zn2+ binding site [ion binding]; other site 156889011436 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 156889011437 trehalose synthase; Region: treS_nterm; TIGR02456 156889011438 active site 156889011439 catalytic site [active] 156889011440 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 156889011441 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 156889011442 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 156889011443 putative ADP-binding pocket [chemical binding]; other site 156889011444 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 156889011445 Methyltransferase domain; Region: Methyltransf_23; pfam13489 156889011446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889011447 S-adenosylmethionine binding site [chemical binding]; other site 156889011448 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 156889011449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 156889011450 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 156889011451 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 156889011452 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09642 156889011453 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 156889011454 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 156889011455 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 156889011456 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 156889011457 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889011458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889011459 dimer interface [polypeptide binding]; other site 156889011460 phosphorylation site [posttranslational modification] 156889011461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889011462 ATP binding site [chemical binding]; other site 156889011463 Mg2+ binding site [ion binding]; other site 156889011464 G-X-G motif; other site 156889011465 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889011466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011467 active site 156889011468 phosphorylation site [posttranslational modification] 156889011469 intermolecular recognition site; other site 156889011470 dimerization interface [polypeptide binding]; other site 156889011471 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889011472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011473 active site 156889011474 phosphorylation site [posttranslational modification] 156889011475 intermolecular recognition site; other site 156889011476 dimerization interface [polypeptide binding]; other site 156889011477 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 156889011478 putative binding surface; other site 156889011479 active site 156889011480 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 156889011481 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889011482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011483 active site 156889011484 phosphorylation site [posttranslational modification] 156889011485 intermolecular recognition site; other site 156889011486 dimerization interface [polypeptide binding]; other site 156889011487 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889011488 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889011489 metal binding site [ion binding]; metal-binding site 156889011490 active site 156889011491 I-site; other site 156889011492 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 156889011493 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 156889011494 Zn2+ binding site [ion binding]; other site 156889011495 Mg2+ binding site [ion binding]; other site 156889011496 PAS domain S-box; Region: sensory_box; TIGR00229 156889011497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889011498 putative active site [active] 156889011499 heme pocket [chemical binding]; other site 156889011500 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889011501 PAS domain; Region: PAS_9; pfam13426 156889011502 putative active site [active] 156889011503 heme pocket [chemical binding]; other site 156889011504 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 156889011505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 156889011506 metal binding site [ion binding]; metal-binding site 156889011507 active site 156889011508 I-site; other site 156889011509 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 156889011510 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 156889011511 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 156889011512 PAS domain; Region: PAS_9; pfam13426 156889011513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889011514 PAS domain; Region: PAS_9; pfam13426 156889011515 putative active site [active] 156889011516 heme pocket [chemical binding]; other site 156889011517 PAS fold; Region: PAS_4; pfam08448 156889011518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 156889011519 putative active site [active] 156889011520 heme pocket [chemical binding]; other site 156889011521 PAS domain; Region: PAS_9; pfam13426 156889011522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889011523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889011524 dimer interface [polypeptide binding]; other site 156889011525 phosphorylation site [posttranslational modification] 156889011526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889011527 ATP binding site [chemical binding]; other site 156889011528 Mg2+ binding site [ion binding]; other site 156889011529 G-X-G motif; other site 156889011530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011531 Response regulator receiver domain; Region: Response_reg; pfam00072 156889011532 active site 156889011533 phosphorylation site [posttranslational modification] 156889011534 intermolecular recognition site; other site 156889011535 dimerization interface [polypeptide binding]; other site 156889011536 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889011537 anti sigma factor interaction site; other site 156889011538 regulatory phosphorylation site [posttranslational modification]; other site 156889011539 Response regulator receiver domain; Region: Response_reg; pfam00072 156889011540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011541 active site 156889011542 phosphorylation site [posttranslational modification] 156889011543 intermolecular recognition site; other site 156889011544 dimerization interface [polypeptide binding]; other site 156889011545 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 156889011546 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 156889011547 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 156889011548 GAF domain; Region: GAF; cl17456 156889011549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 156889011550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889011551 dimer interface [polypeptide binding]; other site 156889011552 phosphorylation site [posttranslational modification] 156889011553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889011554 ATP binding site [chemical binding]; other site 156889011555 Mg2+ binding site [ion binding]; other site 156889011556 G-X-G motif; other site 156889011557 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 156889011558 active site 156889011559 DNA polymerase IV; Validated; Region: PRK02406 156889011560 DNA binding site [nucleotide binding] 156889011561 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 156889011562 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 156889011563 putative NAD(P) binding site [chemical binding]; other site 156889011564 catalytic Zn binding site [ion binding]; other site 156889011565 structural Zn binding site [ion binding]; other site 156889011566 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 156889011567 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 156889011568 active site 156889011569 metal binding site [ion binding]; metal-binding site 156889011570 DNA binding site [nucleotide binding] 156889011571 P-loop containing region of AAA domain; Region: AAA_29; cl17516 156889011572 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 156889011573 dimer interface [polypeptide binding]; other site 156889011574 RNA polymerase sigma factor; Reviewed; Region: PRK05602 156889011575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 156889011576 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 156889011577 DNA binding residues [nucleotide binding] 156889011578 EF-hand domain pair; Region: EF_hand_5; pfam13499 156889011579 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 156889011580 EF-hand domain pair; Region: EF_hand_5; pfam13499 156889011581 Ca2+ binding site [ion binding]; other site 156889011582 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 156889011583 Transcriptional regulator; Region: Rrf2; pfam02082 156889011584 Transcriptional regulator; Region: Rrf2; cl17282 156889011585 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 156889011586 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889011587 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889011588 dimer interface [polypeptide binding]; other site 156889011589 putative CheW interface [polypeptide binding]; other site 156889011590 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 156889011591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 156889011592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889011593 non-specific DNA binding site [nucleotide binding]; other site 156889011594 salt bridge; other site 156889011595 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 156889011596 sequence-specific DNA binding site [nucleotide binding]; other site 156889011597 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 156889011598 Catalytic site [active] 156889011599 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 156889011600 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 156889011601 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889011602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889011603 binding surface 156889011604 TPR motif; other site 156889011605 TPR repeat; Region: TPR_11; pfam13414 156889011606 Cytochrome c; Region: Cytochrom_C; cl11414 156889011607 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 156889011608 PhoU domain; Region: PhoU; pfam01895 156889011609 PhoU domain; Region: PhoU; pfam01895 156889011610 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 156889011611 AMP-binding enzyme; Region: AMP-binding; pfam00501 156889011612 acyl-activating enzyme (AAE) consensus motif; other site 156889011613 putative AMP binding site [chemical binding]; other site 156889011614 putative active site [active] 156889011615 putative CoA binding site [chemical binding]; other site 156889011616 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 156889011617 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 156889011618 substrate binding site [chemical binding]; other site 156889011619 oxyanion hole (OAH) forming residues; other site 156889011620 trimer interface [polypeptide binding]; other site 156889011621 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 156889011622 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 156889011623 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 156889011624 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 156889011625 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 156889011626 dimer interface [polypeptide binding]; other site 156889011627 active site 156889011628 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 156889011629 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 156889011630 active site 156889011631 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 156889011632 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 156889011633 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 156889011634 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 156889011635 N-terminal plug; other site 156889011636 ligand-binding site [chemical binding]; other site 156889011637 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 156889011638 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 156889011639 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 156889011640 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 156889011641 agmatinase; Region: agmatinase; TIGR01230 156889011642 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 156889011643 putative active site [active] 156889011644 Mn binding site [ion binding]; other site 156889011645 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 156889011646 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 156889011647 flagellar motor switch protein FliN; Region: fliN; TIGR02480 156889011648 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 156889011649 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 156889011650 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 156889011651 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 156889011652 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 156889011653 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 156889011654 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 156889011655 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 156889011656 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 156889011657 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 156889011658 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 156889011659 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889011660 dimerization interface [polypeptide binding]; other site 156889011661 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 156889011662 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889011663 dimer interface [polypeptide binding]; other site 156889011664 putative CheW interface [polypeptide binding]; other site 156889011665 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 156889011666 Hemerythrin; Region: Hemerythrin; cd12107 156889011667 Fe binding site [ion binding]; other site 156889011668 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 156889011669 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 156889011670 FMN binding site [chemical binding]; other site 156889011671 substrate binding site [chemical binding]; other site 156889011672 putative catalytic residue [active] 156889011673 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 156889011674 putative binding surface; other site 156889011675 active site 156889011676 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 156889011677 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 156889011678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889011679 ATP binding site [chemical binding]; other site 156889011680 Mg2+ binding site [ion binding]; other site 156889011681 G-X-G motif; other site 156889011682 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 156889011683 Response regulator receiver domain; Region: Response_reg; pfam00072 156889011684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011685 active site 156889011686 phosphorylation site [posttranslational modification] 156889011687 intermolecular recognition site; other site 156889011688 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 156889011689 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 156889011690 dimer interface [polypeptide binding]; other site 156889011691 putative CheW interface [polypeptide binding]; other site 156889011692 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 156889011693 anti sigma factor interaction site; other site 156889011694 regulatory phosphorylation site [posttranslational modification]; other site 156889011695 Response regulator receiver domain; Region: Response_reg; pfam00072 156889011696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011697 active site 156889011698 phosphorylation site [posttranslational modification] 156889011699 intermolecular recognition site; other site 156889011700 dimerization interface [polypeptide binding]; other site 156889011701 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 156889011702 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 156889011703 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 156889011704 ATP binding site [chemical binding]; other site 156889011705 Mg2+ binding site [ion binding]; other site 156889011706 G-X-G motif; other site 156889011707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011708 active site 156889011709 phosphorylation site [posttranslational modification] 156889011710 intermolecular recognition site; other site 156889011711 dimerization interface [polypeptide binding]; other site 156889011712 CheB methylesterase; Region: CheB_methylest; pfam01339 156889011713 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 156889011714 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 156889011715 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 156889011716 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 156889011717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011718 active site 156889011719 phosphorylation site [posttranslational modification] 156889011720 intermolecular recognition site; other site 156889011721 dimerization interface [polypeptide binding]; other site 156889011722 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 156889011723 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 156889011724 Response regulator receiver domain; Region: Response_reg; pfam00072 156889011725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011726 active site 156889011727 phosphorylation site [posttranslational modification] 156889011728 intermolecular recognition site; other site 156889011729 dimerization interface [polypeptide binding]; other site 156889011730 FOG: CBS domain [General function prediction only]; Region: COG0517 156889011731 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 156889011732 GTP-binding protein Der; Reviewed; Region: PRK00093 156889011733 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 156889011734 G1 box; other site 156889011735 GTP/Mg2+ binding site [chemical binding]; other site 156889011736 Switch I region; other site 156889011737 G2 box; other site 156889011738 Switch II region; other site 156889011739 G3 box; other site 156889011740 G4 box; other site 156889011741 G5 box; other site 156889011742 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 156889011743 G1 box; other site 156889011744 GTP/Mg2+ binding site [chemical binding]; other site 156889011745 Switch I region; other site 156889011746 G2 box; other site 156889011747 G3 box; other site 156889011748 Switch II region; other site 156889011749 G4 box; other site 156889011750 G5 box; other site 156889011751 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 156889011752 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 156889011753 Trp docking motif [polypeptide binding]; other site 156889011754 active site 156889011755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 156889011756 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 156889011757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889011758 binding surface 156889011759 TPR motif; other site 156889011760 histidyl-tRNA synthetase; Region: hisS; TIGR00442 156889011761 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 156889011762 dimer interface [polypeptide binding]; other site 156889011763 motif 1; other site 156889011764 active site 156889011765 motif 2; other site 156889011766 motif 3; other site 156889011767 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 156889011768 anticodon binding site; other site 156889011769 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 156889011770 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 156889011771 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 156889011772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 156889011773 non-specific DNA binding site [nucleotide binding]; other site 156889011774 salt bridge; other site 156889011775 sequence-specific DNA binding site [nucleotide binding]; other site 156889011776 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 156889011777 NAD synthetase; Provisional; Region: PRK13981 156889011778 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 156889011779 multimer interface [polypeptide binding]; other site 156889011780 active site 156889011781 catalytic triad [active] 156889011782 protein interface 1 [polypeptide binding]; other site 156889011783 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 156889011784 homodimer interface [polypeptide binding]; other site 156889011785 NAD binding pocket [chemical binding]; other site 156889011786 ATP binding pocket [chemical binding]; other site 156889011787 Mg binding site [ion binding]; other site 156889011788 active-site loop [active] 156889011789 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 156889011790 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 156889011791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889011792 homodimer interface [polypeptide binding]; other site 156889011793 catalytic residue [active] 156889011794 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 156889011795 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 156889011796 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 156889011797 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 156889011798 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 156889011799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889011800 active site 156889011801 phosphorylation site [posttranslational modification] 156889011802 intermolecular recognition site; other site 156889011803 dimerization interface [polypeptide binding]; other site 156889011804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889011805 Walker A motif; other site 156889011806 ATP binding site [chemical binding]; other site 156889011807 Walker B motif; other site 156889011808 arginine finger; other site 156889011809 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 156889011810 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 156889011811 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 156889011812 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 156889011813 dimerization interface [polypeptide binding]; other site 156889011814 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 156889011815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889011816 dimer interface [polypeptide binding]; other site 156889011817 phosphorylation site [posttranslational modification] 156889011818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889011819 ATP binding site [chemical binding]; other site 156889011820 Mg2+ binding site [ion binding]; other site 156889011821 G-X-G motif; other site 156889011822 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 156889011823 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 156889011824 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 156889011825 TrkA-N domain; Region: TrkA_N; pfam02254 156889011826 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 156889011827 GDP-Fucose binding site [chemical binding]; other site 156889011828 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 156889011829 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 156889011830 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 156889011831 Walker A/P-loop; other site 156889011832 ATP binding site [chemical binding]; other site 156889011833 Q-loop/lid; other site 156889011834 ABC transporter signature motif; other site 156889011835 Walker B; other site 156889011836 D-loop; other site 156889011837 H-loop/switch region; other site 156889011838 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 156889011839 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 156889011840 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 156889011841 lipoyl attachment site [posttranslational modification]; other site 156889011842 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889011843 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889011844 DDE superfamily endonuclease; Region: DDE_5; cl17874 156889011845 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889011846 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 156889011847 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 156889011848 Methyltransferase domain; Region: Methyltransf_31; pfam13847 156889011849 Methyltransferase domain; Region: Methyltransf_11; pfam08241 156889011850 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 156889011851 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 156889011852 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 156889011853 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 156889011854 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 156889011855 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 156889011856 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 156889011857 TRAM domain; Region: TRAM; pfam01938 156889011858 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 156889011859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889011860 S-adenosylmethionine binding site [chemical binding]; other site 156889011861 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 156889011862 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 156889011863 Tetramer interface [polypeptide binding]; other site 156889011864 active site 156889011865 FMN-binding site [chemical binding]; other site 156889011866 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 156889011867 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 156889011868 NAD binding site [chemical binding]; other site 156889011869 homotetramer interface [polypeptide binding]; other site 156889011870 homodimer interface [polypeptide binding]; other site 156889011871 substrate binding site [chemical binding]; other site 156889011872 active site 156889011873 Uncharacterized conserved protein [Function unknown]; Region: COG1565 156889011874 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 156889011875 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 156889011876 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 156889011877 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 156889011878 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 156889011879 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 156889011880 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 156889011881 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 156889011882 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 156889011883 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 156889011884 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 156889011885 4Fe-4S binding domain; Region: Fer4; cl02805 156889011886 4Fe-4S binding domain; Region: Fer4; pfam00037 156889011887 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 156889011888 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 156889011889 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 156889011890 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 156889011891 catalytic loop [active] 156889011892 iron binding site [ion binding]; other site 156889011893 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 156889011894 MopB_NADH-Q-OR-NuoG2: The NuoG/Nad11/75-kDa subunit (second domain) of the NADH-quinone oxidoreductase (NADH-Q-OR)/respiratory complex I/NADH dehydrogenase-1 (NDH-1). The NADH-Q-OR is the first energy-transducting complex in the respiratory chains of...; Region: MopB_NADH-Q-OR-NuoG2; cd02768 156889011895 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 156889011896 molybdopterin cofactor binding site; other site 156889011897 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 156889011898 SLBB domain; Region: SLBB; pfam10531 156889011899 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 156889011900 NADH dehydrogenase subunit E; Validated; Region: PRK07539 156889011901 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 156889011902 putative dimer interface [polypeptide binding]; other site 156889011903 [2Fe-2S] cluster binding site [ion binding]; other site 156889011904 NADH dehydrogenase subunit D; Validated; Region: PRK06075 156889011905 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 156889011906 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 156889011907 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 156889011908 NADH dehydrogenase subunit B; Validated; Region: PRK06411 156889011909 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 156889011910 Transposase [DNA replication, recombination, and repair]; Region: COG5421 156889011911 CoA binding domain; Region: CoA_binding; cl17356 156889011912 succinyl-CoA synthetase, alpha subunit; Region: sucCoAalpha; TIGR01019 156889011913 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 156889011914 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 156889011915 active site 156889011916 oxalacetate binding site [chemical binding]; other site 156889011917 citrylCoA binding site [chemical binding]; other site 156889011918 coenzyme A binding site [chemical binding]; other site 156889011919 catalytic triad [active] 156889011920 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 156889011921 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 156889011922 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 156889011923 Found in ATP-dependent protease La (LON); Region: LON; smart00464 156889011924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889011925 Walker A motif; other site 156889011926 ATP binding site [chemical binding]; other site 156889011927 Walker B motif; other site 156889011928 arginine finger; other site 156889011929 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 156889011930 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 156889011931 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 156889011932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889011933 Walker A motif; other site 156889011934 ATP binding site [chemical binding]; other site 156889011935 Walker B motif; other site 156889011936 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 156889011937 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 156889011938 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 156889011939 oligomer interface [polypeptide binding]; other site 156889011940 active site residues [active] 156889011941 trigger factor; Region: tig; TIGR00115 156889011942 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 156889011943 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 156889011944 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 156889011945 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 156889011946 tRNA; other site 156889011947 putative tRNA binding site [nucleotide binding]; other site 156889011948 putative NADP binding site [chemical binding]; other site 156889011949 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 156889011950 peptide chain release factor 1; Validated; Region: prfA; PRK00591 156889011951 This domain is found in peptide chain release factors; Region: PCRF; smart00937 156889011952 RF-1 domain; Region: RF-1; pfam00472 156889011953 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 156889011954 active site 156889011955 catalytic site [active] 156889011956 substrate binding site [chemical binding]; other site 156889011957 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 156889011958 threonine ammonia-lyase, biosynthetic, long form; Region: ilvA_2Cterm; TIGR01124 156889011959 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 156889011960 tetramer interface [polypeptide binding]; other site 156889011961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889011962 catalytic residue [active] 156889011963 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 156889011964 putative Ile/Val binding site [chemical binding]; other site 156889011965 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 156889011966 putative Ile/Val binding site [chemical binding]; other site 156889011967 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 156889011968 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 156889011969 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 156889011970 substrate binding site [chemical binding]; other site 156889011971 hexamer interface [polypeptide binding]; other site 156889011972 metal binding site [ion binding]; metal-binding site 156889011973 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 156889011974 active site 156889011975 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 156889011976 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 156889011977 active site 156889011978 HIGH motif; other site 156889011979 nucleotide binding site [chemical binding]; other site 156889011980 active site 156889011981 KMSKS motif; other site 156889011982 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 156889011983 putative CheA interaction surface; other site 156889011984 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 156889011985 YGGT family; Region: YGGT; pfam02325 156889011986 YGGT family; Region: YGGT; pfam02325 156889011987 pyrroline-5-carboxylate reductase; Region: PLN02688 156889011988 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 156889011989 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 156889011990 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 156889011991 catalytic residue [active] 156889011992 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 156889011993 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 156889011994 catalytic residues [active] 156889011995 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 156889011996 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 156889011997 DNA topoisomerase I; Validated; Region: PRK06599 156889011998 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 156889011999 active site 156889012000 interdomain interaction site; other site 156889012001 putative metal-binding site [ion binding]; other site 156889012002 nucleotide binding site [chemical binding]; other site 156889012003 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 156889012004 domain I; other site 156889012005 DNA binding groove [nucleotide binding] 156889012006 phosphate binding site [ion binding]; other site 156889012007 domain II; other site 156889012008 domain III; other site 156889012009 nucleotide binding site [chemical binding]; other site 156889012010 catalytic site [active] 156889012011 domain IV; other site 156889012012 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 156889012013 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 156889012014 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 156889012015 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 156889012016 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 156889012017 DNA protecting protein DprA; Region: dprA; TIGR00732 156889012018 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 156889012019 Methyltransferase domain; Region: Methyltransf_24; pfam13578 156889012020 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 156889012021 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 156889012022 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 156889012023 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 156889012024 dimer interface [polypeptide binding]; other site 156889012025 ssDNA binding site [nucleotide binding]; other site 156889012026 tetramer (dimer of dimers) interface [polypeptide binding]; other site 156889012027 hydroxyglutarate oxidase; Provisional; Region: PRK11728 156889012028 NusB family; Region: NusB; pfam01029 156889012029 16S rRNA methyltransferase B; Provisional; Region: PRK14902 156889012030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889012031 S-adenosylmethionine binding site [chemical binding]; other site 156889012032 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 156889012033 G1 box; other site 156889012034 GTP/Mg2+ binding site [chemical binding]; other site 156889012035 Switch I region; other site 156889012036 G2 box; other site 156889012037 G3 box; other site 156889012038 Switch II region; other site 156889012039 G4 box; other site 156889012040 G5 box; other site 156889012041 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 156889012042 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 156889012043 FMN binding site [chemical binding]; other site 156889012044 active site 156889012045 catalytic residues [active] 156889012046 substrate binding site [chemical binding]; other site 156889012047 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 156889012048 PAS domain; Region: PAS; smart00091 156889012049 putative active site [active] 156889012050 heme pocket [chemical binding]; other site 156889012051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889012052 dimer interface [polypeptide binding]; other site 156889012053 phosphorylation site [posttranslational modification] 156889012054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889012055 ATP binding site [chemical binding]; other site 156889012056 Mg2+ binding site [ion binding]; other site 156889012057 G-X-G motif; other site 156889012058 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 156889012059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889012060 active site 156889012061 phosphorylation site [posttranslational modification] 156889012062 intermolecular recognition site; other site 156889012063 dimerization interface [polypeptide binding]; other site 156889012064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 156889012065 Walker A motif; other site 156889012066 ATP binding site [chemical binding]; other site 156889012067 Walker B motif; other site 156889012068 arginine finger; other site 156889012069 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 156889012070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 156889012071 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 156889012072 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 156889012073 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 156889012074 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 156889012075 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 156889012076 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 156889012077 glutamate--cysteine ligase, plant type; Region: glu_cys_lig_pln; TIGR01436 156889012078 Ion channel; Region: Ion_trans_2; pfam07885 156889012079 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 156889012080 TrkA-N domain; Region: TrkA_N; pfam02254 156889012081 TrkA-C domain; Region: TrkA_C; pfam02080 156889012082 putative glutathione S-transferase; Provisional; Region: PRK10357 156889012083 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 156889012084 putative C-terminal domain interface [polypeptide binding]; other site 156889012085 putative GSH binding site (G-site) [chemical binding]; other site 156889012086 putative dimer interface [polypeptide binding]; other site 156889012087 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 156889012088 dimer interface [polypeptide binding]; other site 156889012089 N-terminal domain interface [polypeptide binding]; other site 156889012090 putative substrate binding pocket (H-site) [chemical binding]; other site 156889012091 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 156889012092 feedback inhibition sensing region; other site 156889012093 homohexameric interface [polypeptide binding]; other site 156889012094 nucleotide binding site [chemical binding]; other site 156889012095 N-acetyl-L-glutamate binding site [chemical binding]; other site 156889012096 Bacterial SH3 domain homologues; Region: SH3b; smart00287 156889012097 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 156889012098 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 156889012099 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 156889012100 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 156889012101 hydroxyglutarate oxidase; Provisional; Region: PRK11728 156889012102 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 156889012103 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 156889012104 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 156889012105 active site 156889012106 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 156889012107 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 156889012108 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 156889012109 nucleotide binding pocket [chemical binding]; other site 156889012110 K-X-D-G motif; other site 156889012111 catalytic site [active] 156889012112 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 156889012113 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 156889012114 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 156889012115 Dimer interface [polypeptide binding]; other site 156889012116 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 156889012117 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 156889012118 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 156889012119 substrate binding pocket [chemical binding]; other site 156889012120 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 156889012121 B12 binding site [chemical binding]; other site 156889012122 cobalt ligand [ion binding]; other site 156889012123 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 156889012124 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 156889012125 DNA binding residues [nucleotide binding] 156889012126 B12 binding domain; Region: B12-binding_2; pfam02607 156889012127 Response regulator receiver domain; Region: Response_reg; pfam00072 156889012128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889012129 active site 156889012130 phosphorylation site [posttranslational modification] 156889012131 intermolecular recognition site; other site 156889012132 dimerization interface [polypeptide binding]; other site 156889012133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 156889012134 dimer interface [polypeptide binding]; other site 156889012135 phosphorylation site [posttranslational modification] 156889012136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 156889012137 ATP binding site [chemical binding]; other site 156889012138 Mg2+ binding site [ion binding]; other site 156889012139 G-X-G motif; other site 156889012140 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 156889012141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 156889012142 active site 156889012143 phosphorylation site [posttranslational modification] 156889012144 intermolecular recognition site; other site 156889012145 dimerization interface [polypeptide binding]; other site 156889012146 VCBS repeat; Region: VCBS_repeat; TIGR01965 156889012147 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 156889012148 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 156889012149 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 156889012150 FG-GAP repeat; Region: FG-GAP; cl15299 156889012151 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 156889012152 Sel1-like repeats; Region: SEL1; smart00671 156889012153 Sel1-like repeats; Region: SEL1; smart00671 156889012154 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889012155 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889012156 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889012157 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889012158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889012159 TPR motif; other site 156889012160 binding surface 156889012161 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889012162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889012163 TPR motif; other site 156889012164 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889012165 binding surface 156889012166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889012167 TPR motif; other site 156889012168 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889012169 binding surface 156889012170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 156889012171 Tetratricopeptide repeat; Region: TPR_10; pfam13374 156889012172 CHAT domain; Region: CHAT; pfam12770 156889012173 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 156889012174 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 156889012175 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 156889012176 cyclase homology domain; Region: CHD; cd07302 156889012177 nucleotidyl binding site; other site 156889012178 metal binding site [ion binding]; metal-binding site 156889012179 dimer interface [polypeptide binding]; other site 156889012180 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 156889012181 RNA binding surface [nucleotide binding]; other site 156889012182 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 156889012183 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 156889012184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889012185 S-adenosylmethionine binding site [chemical binding]; other site 156889012186 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 156889012187 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 156889012188 DNA binding residues [nucleotide binding] 156889012189 dimerization interface [polypeptide binding]; other site 156889012190 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 156889012191 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 156889012192 putative active site [active] 156889012193 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 156889012194 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 156889012195 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 156889012196 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 156889012197 MPN+ (JAMM) motif; other site 156889012198 Zinc-binding site [ion binding]; other site 156889012199 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 156889012200 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 156889012201 Ligand Binding Site [chemical binding]; other site 156889012202 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 156889012203 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 156889012204 active site 156889012205 ATP binding site [chemical binding]; other site 156889012206 substrate binding site [chemical binding]; other site 156889012207 activation loop (A-loop); other site 156889012208 Sporulation related domain; Region: SPOR; pfam05036 156889012209 Sporulation related domain; Region: SPOR; pfam05036 156889012210 Sporulation related domain; Region: SPOR; pfam05036 156889012211 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 156889012212 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 156889012213 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 156889012214 homodimer interface [polypeptide binding]; other site 156889012215 NADP binding site [chemical binding]; other site 156889012216 substrate binding site [chemical binding]; other site 156889012217 Domain of unknown function DUF302; Region: DUF302; cl01364 156889012218 Cytochrome c; Region: Cytochrom_C; pfam00034 156889012219 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 156889012220 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 156889012221 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 156889012222 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 156889012223 catalytic residues [active] 156889012224 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 156889012225 catalytic residues [active] 156889012226 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 156889012227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 156889012228 Walker A/P-loop; other site 156889012229 ATP binding site [chemical binding]; other site 156889012230 Q-loop/lid; other site 156889012231 ABC transporter signature motif; other site 156889012232 Walker B; other site 156889012233 D-loop; other site 156889012234 H-loop/switch region; other site 156889012235 TPR repeat; Region: TPR_11; pfam13414 156889012236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889012237 TPR motif; other site 156889012238 binding surface 156889012239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 156889012240 binding surface 156889012241 TPR motif; other site 156889012242 Tetratricopeptide repeat; Region: TPR_16; pfam13432 156889012243 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 156889012244 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 156889012245 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 156889012246 RNase E interface [polypeptide binding]; other site 156889012247 trimer interface [polypeptide binding]; other site 156889012248 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 156889012249 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 156889012250 RNase E interface [polypeptide binding]; other site 156889012251 trimer interface [polypeptide binding]; other site 156889012252 active site 156889012253 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 156889012254 putative nucleic acid binding region [nucleotide binding]; other site 156889012255 G-X-X-G motif; other site 156889012256 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 156889012257 RNA binding site [nucleotide binding]; other site 156889012258 domain interface; other site 156889012259 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 156889012260 16S/18S rRNA binding site [nucleotide binding]; other site 156889012261 S13e-L30e interaction site [polypeptide binding]; other site 156889012262 25S rRNA binding site [nucleotide binding]; other site 156889012263 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 156889012264 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 156889012265 RNA binding site [nucleotide binding]; other site 156889012266 active site 156889012267 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 156889012268 Ribosome-binding factor A; Region: RBFA; pfam02033 156889012269 Protein of unknown function (DUF503); Region: DUF503; pfam04456 156889012270 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 156889012271 translation initiation factor IF-2; Region: IF-2; TIGR00487 156889012272 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 156889012273 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 156889012274 G1 box; other site 156889012275 putative GEF interaction site [polypeptide binding]; other site 156889012276 GTP/Mg2+ binding site [chemical binding]; other site 156889012277 Switch I region; other site 156889012278 G2 box; other site 156889012279 G3 box; other site 156889012280 Switch II region; other site 156889012281 G4 box; other site 156889012282 G5 box; other site 156889012283 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 156889012284 Translation-initiation factor 2; Region: IF-2; pfam11987 156889012285 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 156889012286 Protein of unknown function (DUF448); Region: DUF448; pfam04296 156889012287 putative RNA binding cleft [nucleotide binding]; other site 156889012288 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 156889012289 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 156889012290 NusA N-terminal domain; Region: NusA_N; pfam08529 156889012291 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 156889012292 RNA binding site [nucleotide binding]; other site 156889012293 homodimer interface [polypeptide binding]; other site 156889012294 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 156889012295 G-X-X-G motif; other site 156889012296 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 156889012297 G-X-X-G motif; other site 156889012298 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 156889012299 ribosome maturation protein RimP; Reviewed; Region: PRK00092 156889012300 Sm and related proteins; Region: Sm_like; cl00259 156889012301 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 156889012302 putative oligomer interface [polypeptide binding]; other site 156889012303 putative RNA binding site [nucleotide binding]; other site 156889012304 Septum formation initiator; Region: DivIC; pfam04977 156889012305 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 156889012306 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 156889012307 active site 156889012308 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 156889012309 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 156889012310 ThiC family; Region: ThiC; pfam01964 156889012311 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 156889012312 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 156889012313 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 156889012314 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 156889012315 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 156889012316 FMN binding site [chemical binding]; other site 156889012317 substrate binding site [chemical binding]; other site 156889012318 putative catalytic residue [active] 156889012319 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 156889012320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 156889012321 ATP binding site [chemical binding]; other site 156889012322 putative Mg++ binding site [ion binding]; other site 156889012323 helicase superfamily c-terminal domain; Region: HELICc; smart00490 156889012324 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 156889012325 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 156889012326 inhibitor-cofactor binding pocket; inhibition site 156889012327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889012328 catalytic residue [active] 156889012329 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 156889012330 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 156889012331 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 156889012332 diaminopimelate decarboxylase; Region: lysA; TIGR01048 156889012333 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 156889012334 active site 156889012335 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 156889012336 substrate binding site [chemical binding]; other site 156889012337 catalytic residues [active] 156889012338 dimer interface [polypeptide binding]; other site 156889012339 argininosuccinate lyase; Provisional; Region: PRK00855 156889012340 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 156889012341 active sites [active] 156889012342 tetramer interface [polypeptide binding]; other site 156889012343 argininosuccinate synthase; Provisional; Region: PRK13820 156889012344 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 156889012345 ANP binding site [chemical binding]; other site 156889012346 Substrate Binding Site II [chemical binding]; other site 156889012347 Substrate Binding Site I [chemical binding]; other site 156889012348 ornithine carbamoyltransferase; Provisional; Region: PRK00779 156889012349 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 156889012350 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 156889012351 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 156889012352 acetylornithine aminotransferase; Provisional; Region: PRK02627 156889012353 inhibitor-cofactor binding pocket; inhibition site 156889012354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 156889012355 catalytic residue [active] 156889012356 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 156889012357 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 156889012358 CPxP motif; other site 156889012359 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 156889012360 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 156889012361 ParB-like nuclease domain; Region: ParB; smart00470 156889012362 KorB domain; Region: KorB; pfam08535 156889012363 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 156889012364 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 156889012365 Magnesium ion binding site [ion binding]; other site 156889012366 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 156889012367 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 156889012368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 156889012369 S-adenosylmethionine binding site [chemical binding]; other site 156889012370 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 156889012371 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 156889012372 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 156889012373 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 156889012374 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 156889012375 trmE is a tRNA modification GTPase; Region: trmE; cd04164 156889012376 G1 box; other site 156889012377 GTP/Mg2+ binding site [chemical binding]; other site 156889012378 Switch I region; other site 156889012379 G2 box; other site 156889012380 Switch II region; other site 156889012381 G3 box; other site 156889012382 G4 box; other site 156889012383 G5 box; other site 156889012384 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 156889012385 membrane protein insertase; Provisional; Region: PRK01318 156889012386 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 156889012387 Haemolytic domain; Region: Haemolytic; pfam01809 156889012388 Ribonuclease P; Region: Ribonuclease_P; pfam00825 156889012389 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399