-- dump date   	20140619_135046
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
697281000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
697281000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
697281000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281000004	Walker A motif; other site
697281000005	ATP binding site [chemical binding]; other site
697281000006	Walker B motif; other site
697281000007	arginine finger; other site
697281000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
697281000009	DnaA box-binding interface [nucleotide binding]; other site
697281000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
697281000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
697281000012	putative DNA binding surface [nucleotide binding]; other site
697281000013	dimer interface [polypeptide binding]; other site
697281000014	beta-clamp/clamp loader binding surface; other site
697281000015	beta-clamp/translesion DNA polymerase binding surface; other site
697281000016	recombination protein F; Reviewed; Region: recF; PRK00064
697281000017	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
697281000018	Walker A/P-loop; other site
697281000019	ATP binding site [chemical binding]; other site
697281000020	Q-loop/lid; other site
697281000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281000022	ABC transporter signature motif; other site
697281000023	Walker B; other site
697281000024	D-loop; other site
697281000025	H-loop/switch region; other site
697281000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
697281000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281000028	Mg2+ binding site [ion binding]; other site
697281000029	G-X-G motif; other site
697281000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
697281000031	anchoring element; other site
697281000032	dimer interface [polypeptide binding]; other site
697281000033	ATP binding site [chemical binding]; other site
697281000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
697281000035	active site
697281000036	putative metal-binding site [ion binding]; other site
697281000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
697281000038	Bacterial SH3 domain; Region: SH3_3; pfam08239
697281000039	Bacterial SH3 domain; Region: SH3_3; pfam08239
697281000040	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
697281000041	NlpC/P60 family; Region: NLPC_P60; pfam00877
697281000042	DNA gyrase subunit A; Validated; Region: PRK05560
697281000043	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
697281000044	CAP-like domain; other site
697281000045	active site
697281000046	primary dimer interface [polypeptide binding]; other site
697281000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
697281000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
697281000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
697281000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
697281000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
697281000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
697281000053	Hemerythrin; Region: Hemerythrin; cd12107
697281000054	Fe binding site [ion binding]; other site
697281000055	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281000056	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281000057	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281000058	Transcriptional regulators [Transcription]; Region: GntR; COG1802
697281000059	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
697281000060	DNA-binding site [nucleotide binding]; DNA binding site
697281000061	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281000062	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281000063	dimerization interface [polypeptide binding]; other site
697281000064	ligand binding site [chemical binding]; other site
697281000065	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
697281000066	active site
697281000067	catalytic site [active]
697281000068	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
697281000069	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
697281000070	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281000071	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281000072	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281000073	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281000074	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281000075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000076	dimer interface [polypeptide binding]; other site
697281000077	conserved gate region; other site
697281000078	putative PBP binding loops; other site
697281000079	ABC-ATPase subunit interface; other site
697281000080	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281000081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000082	dimer interface [polypeptide binding]; other site
697281000083	conserved gate region; other site
697281000084	putative PBP binding loops; other site
697281000085	ABC-ATPase subunit interface; other site
697281000086	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
697281000087	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
697281000088	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281000089	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281000090	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281000091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000092	dimer interface [polypeptide binding]; other site
697281000093	conserved gate region; other site
697281000094	putative PBP binding loops; other site
697281000095	ABC-ATPase subunit interface; other site
697281000096	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281000097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000098	dimer interface [polypeptide binding]; other site
697281000099	conserved gate region; other site
697281000100	putative PBP binding loops; other site
697281000101	ABC-ATPase subunit interface; other site
697281000102	NHL repeat; Region: NHL; pfam01436
697281000103	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
697281000104	TPR repeat; Region: TPR_11; pfam13414
697281000105	binding surface
697281000106	TPR motif; other site
697281000107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000108	ABC-ATPase subunit interface; other site
697281000109	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281000110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000111	dimer interface [polypeptide binding]; other site
697281000112	conserved gate region; other site
697281000113	putative PBP binding loops; other site
697281000114	ABC-ATPase subunit interface; other site
697281000115	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281000116	Trehalase; Region: Trehalase; cl17346
697281000117	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281000118	Cupin domain; Region: Cupin_2; pfam07883
697281000119	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
697281000120	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281000121	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281000122	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281000123	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
697281000124	active site
697281000125	catalytic site [active]
697281000126	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
697281000127	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
697281000128	peptidase T; Region: peptidase-T; TIGR01882
697281000129	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
697281000130	metal binding site [ion binding]; metal-binding site
697281000131	dimer interface [polypeptide binding]; other site
697281000132	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
697281000133	Coenzyme A binding pocket [chemical binding]; other site
697281000134	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281000135	dimerization interface [polypeptide binding]; other site
697281000136	putative DNA binding site [nucleotide binding]; other site
697281000137	putative Zn2+ binding site [ion binding]; other site
697281000138	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
697281000139	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
697281000140	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
697281000141	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
697281000142	active site residue [active]
697281000143	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
697281000144	CPxP  motif; other site
697281000145	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
697281000146	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
697281000147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
697281000148	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
697281000149	Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995
697281000150	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
697281000151	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
697281000152	dimer interface [polypeptide binding]; other site
697281000153	active site
697281000154	metal binding site [ion binding]; metal-binding site
697281000155	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
697281000156	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
697281000157	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
697281000158	Low molecular weight phosphatase family; Region: LMWPc; cd00115
697281000159	active site
697281000160	Cache domain; Region: Cache_1; pfam02743
697281000161	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281000162	dimerization interface [polypeptide binding]; other site
697281000163	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
697281000164	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
697281000165	dimer interface [polypeptide binding]; other site
697281000166	putative CheW interface [polypeptide binding]; other site
697281000167	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
697281000168	Bacterial sugar transferase; Region: Bac_transf; pfam02397
697281000169	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
697281000170	hypothetical protein; Provisional; Region: PRK06770
697281000171	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
697281000172	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
697281000173	active site
697281000174	metal binding site [ion binding]; metal-binding site
697281000175	Sporulation related domain; Region: SPOR; pfam05036
697281000176	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
697281000177	active site
697281000178	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
697281000179	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
697281000180	Phage tail protein; Region: Sipho_tail; pfam05709
697281000181	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
697281000182	membrane protein P6; Region: PHA01399
697281000183	membrane protein P6; Region: PHA01399
697281000184	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
697281000185	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
697281000186	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
697281000187	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
697281000188	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
697281000189	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
697281000190	DNA binding residues [nucleotide binding]
697281000191	Recombination protein U; Region: RecU; cl01314
697281000192	Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417
697281000193	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
697281000194	Helix-turn-helix domain; Region: HTH_17; pfam12728
697281000195	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
697281000196	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
697281000197	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281000198	non-specific DNA binding site [nucleotide binding]; other site
697281000199	salt bridge; other site
697281000200	sequence-specific DNA binding site [nucleotide binding]; other site
697281000201	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
697281000202	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281000203	non-specific DNA binding site [nucleotide binding]; other site
697281000204	salt bridge; other site
697281000205	sequence-specific DNA binding site [nucleotide binding]; other site
697281000206	Domain of unknown function (DUF955); Region: DUF955; cl01076
697281000207	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
697281000208	active site
697281000209	catalytic site [active]
697281000210	substrate binding site [chemical binding]; other site
697281000211	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
697281000212	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
697281000213	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
697281000214	Int/Topo IB signature motif; other site
697281000215	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
697281000216	Lipase (class 2); Region: Lipase_2; pfam01674
697281000217	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
697281000218	Sterol carrier protein domain; Region: SCP2_2; pfam13530
697281000219	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
697281000220	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
697281000221	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
697281000222	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
697281000223	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
697281000224	phosphate binding site [ion binding]; other site
697281000225	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
697281000226	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
697281000227	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
697281000228	active site
697281000229	CotH protein; Region: CotH; pfam08757
697281000230	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
697281000231	putative metal binding residues [ion binding]; other site
697281000232	signature motif; other site
697281000233	dimer interface [polypeptide binding]; other site
697281000234	active site
697281000235	polyP binding site; other site
697281000236	substrate binding site [chemical binding]; other site
697281000237	acceptor-phosphate pocket; other site
697281000238	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
697281000239	HAMP domain; Region: HAMP; pfam00672
697281000240	dimerization interface [polypeptide binding]; other site
697281000241	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
697281000242	dimer interface [polypeptide binding]; other site
697281000243	phosphorylation site [posttranslational modification]
697281000244	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281000245	ATP binding site [chemical binding]; other site
697281000246	Mg2+ binding site [ion binding]; other site
697281000247	G-X-G motif; other site
697281000248	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
697281000249	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281000250	active site
697281000251	phosphorylation site [posttranslational modification]
697281000252	intermolecular recognition site; other site
697281000253	dimerization interface [polypeptide binding]; other site
697281000254	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
697281000255	DNA binding site [nucleotide binding]
697281000256	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
697281000257	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
697281000258	Walker A/P-loop; other site
697281000259	ATP binding site [chemical binding]; other site
697281000260	Q-loop/lid; other site
697281000261	ABC transporter signature motif; other site
697281000262	Walker B; other site
697281000263	D-loop; other site
697281000264	H-loop/switch region; other site
697281000265	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
697281000266	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
697281000267	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
697281000268	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
697281000269	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
697281000270	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
697281000271	Walker A/P-loop; other site
697281000272	ATP binding site [chemical binding]; other site
697281000273	Q-loop/lid; other site
697281000274	ABC transporter signature motif; other site
697281000275	Walker B; other site
697281000276	D-loop; other site
697281000277	H-loop/switch region; other site
697281000278	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
697281000279	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
697281000280	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
697281000281	TM-ABC transporter signature motif; other site
697281000282	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
697281000283	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
697281000284	ligand binding site [chemical binding]; other site
697281000285	HAMP domain; Region: HAMP; pfam00672
697281000286	dimerization interface [polypeptide binding]; other site
697281000287	Histidine kinase; Region: His_kinase; pfam06580
697281000288	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
697281000289	Response regulator receiver domain; Region: Response_reg; pfam00072
697281000290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281000291	active site
697281000292	phosphorylation site [posttranslational modification]
697281000293	intermolecular recognition site; other site
697281000294	dimerization interface [polypeptide binding]; other site
697281000295	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281000296	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281000297	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281000298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000299	dimer interface [polypeptide binding]; other site
697281000300	conserved gate region; other site
697281000301	ABC-ATPase subunit interface; other site
697281000302	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281000303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000304	dimer interface [polypeptide binding]; other site
697281000305	conserved gate region; other site
697281000306	ABC-ATPase subunit interface; other site
697281000307	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281000308	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281000309	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281000310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000311	dimer interface [polypeptide binding]; other site
697281000312	conserved gate region; other site
697281000313	ABC-ATPase subunit interface; other site
697281000314	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281000315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000316	dimer interface [polypeptide binding]; other site
697281000317	conserved gate region; other site
697281000318	putative PBP binding loops; other site
697281000319	ABC-ATPase subunit interface; other site
697281000320	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281000321	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281000322	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
697281000323	metal binding site [ion binding]; metal-binding site
697281000324	active site
697281000325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281000326	Response regulator receiver domain; Region: Response_reg; pfam00072
697281000327	active site
697281000328	phosphorylation site [posttranslational modification]
697281000329	intermolecular recognition site; other site
697281000330	dimerization interface [polypeptide binding]; other site
697281000331	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281000332	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281000333	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
697281000334	HAMP domain; Region: HAMP; pfam00672
697281000335	Histidine kinase; Region: His_kinase; pfam06580
697281000336	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281000337	ATP binding site [chemical binding]; other site
697281000338	Mg2+ binding site [ion binding]; other site
697281000339	G-X-G motif; other site
697281000340	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281000341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000342	dimer interface [polypeptide binding]; other site
697281000343	conserved gate region; other site
697281000344	putative PBP binding loops; other site
697281000345	ABC-ATPase subunit interface; other site
697281000346	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281000347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000348	dimer interface [polypeptide binding]; other site
697281000349	conserved gate region; other site
697281000350	putative PBP binding loops; other site
697281000351	ABC-ATPase subunit interface; other site
697281000352	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281000353	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281000354	Helix-turn-helix domain; Region: HTH_28; pfam13518
697281000355	Winged helix-turn helix; Region: HTH_29; pfam13551
697281000356	Integrase core domain; Region: rve; pfam00665
697281000357	Integrase core domain; Region: rve_3; cl15866
697281000358	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281000359	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281000360	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281000361	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281000362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000363	dimer interface [polypeptide binding]; other site
697281000364	conserved gate region; other site
697281000365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
697281000366	ABC-ATPase subunit interface; other site
697281000367	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281000368	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000369	dimer interface [polypeptide binding]; other site
697281000370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
697281000371	ABC-ATPase subunit interface; other site
697281000372	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000373	dimer interface [polypeptide binding]; other site
697281000374	conserved gate region; other site
697281000375	putative PBP binding loops; other site
697281000376	ABC-ATPase subunit interface; other site
697281000377	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281000378	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000379	dimer interface [polypeptide binding]; other site
697281000380	conserved gate region; other site
697281000381	putative PBP binding loops; other site
697281000382	ABC-ATPase subunit interface; other site
697281000383	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281000384	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281000385	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
697281000386	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
697281000387	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
697281000388	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
697281000389	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281000390	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281000391	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
697281000392	N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754
697281000393	catalytic domain interface [polypeptide binding]; other site
697281000394	homodimer interface [polypeptide binding]; other site
697281000395	putative active site [active]
697281000396	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
697281000397	tartrate dehydrogenase; Region: TTC; TIGR02089
697281000398	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
697281000399	HTH domain; Region: HTH_11; pfam08279
697281000400	3H domain; Region: 3H; pfam02829
697281000401	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281000402	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281000403	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281000404	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
697281000405	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
697281000406	substrate binding site [chemical binding]; other site
697281000407	ATP binding site [chemical binding]; other site
697281000408	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
697281000409	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
697281000410	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
697281000411	active site
697281000412	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
697281000413	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
697281000414	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
697281000415	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
697281000416	active site
697281000417	motif I; other site
697281000418	motif II; other site
697281000419	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
697281000420	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
697281000421	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281000422	FeS/SAM binding site; other site
697281000423	MjaII restriction endonuclease; Region: RE_MjaII; pfam09520
697281000424	DNA methylase; Region: N6_N4_Mtase; cl17433
697281000425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
697281000426	putative substrate translocation pore; other site
697281000427	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
697281000428	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
697281000429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281000430	Walker A motif; other site
697281000431	ATP binding site [chemical binding]; other site
697281000432	Walker B motif; other site
697281000433	DNA polymerase III subunit delta'; Validated; Region: PRK08485
697281000434	arginine finger; other site
697281000435	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
697281000436	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
697281000437	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
697281000438	NAD(P) binding site [chemical binding]; other site
697281000439	LDH/MDH dimer interface [polypeptide binding]; other site
697281000440	substrate binding site [chemical binding]; other site
697281000441	hypothetical protein; Validated; Region: PRK00153
697281000442	recombination protein RecR; Reviewed; Region: recR; PRK00076
697281000443	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
697281000444	RecR protein; Region: RecR; pfam02132
697281000445	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
697281000446	putative active site [active]
697281000447	putative metal-binding site [ion binding]; other site
697281000448	tetramer interface [polypeptide binding]; other site
697281000449	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
697281000450	SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466
697281000451	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
697281000452	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
697281000453	DNA-binding site [nucleotide binding]; DNA binding site
697281000454	UTRA domain; Region: UTRA; pfam07702
697281000455	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
697281000456	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
697281000457	dimer interface [polypeptide binding]; other site
697281000458	active site
697281000459	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
697281000460	dimer interface [polypeptide binding]; other site
697281000461	active site
697281000462	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281000463	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281000464	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
697281000465	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
697281000466	active site
697281000467	metal binding site [ion binding]; metal-binding site
697281000468	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
697281000469	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
697281000470	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
697281000471	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
697281000472	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
697281000473	FtsX-like permease family; Region: FtsX; pfam02687
697281000474	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
697281000475	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
697281000476	Walker A/P-loop; other site
697281000477	ATP binding site [chemical binding]; other site
697281000478	Q-loop/lid; other site
697281000479	ABC transporter signature motif; other site
697281000480	Walker B; other site
697281000481	D-loop; other site
697281000482	H-loop/switch region; other site
697281000483	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
697281000484	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
697281000485	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
697281000486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281000487	ATP binding site [chemical binding]; other site
697281000488	Mg2+ binding site [ion binding]; other site
697281000489	G-X-G motif; other site
697281000490	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
697281000491	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281000492	active site
697281000493	phosphorylation site [posttranslational modification]
697281000494	intermolecular recognition site; other site
697281000495	dimerization interface [polypeptide binding]; other site
697281000496	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
697281000497	DNA binding site [nucleotide binding]
697281000498	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281000499	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281000500	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281000501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000502	dimer interface [polypeptide binding]; other site
697281000503	conserved gate region; other site
697281000504	ABC-ATPase subunit interface; other site
697281000505	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281000506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000507	dimer interface [polypeptide binding]; other site
697281000508	conserved gate region; other site
697281000509	putative PBP binding loops; other site
697281000510	ABC-ATPase subunit interface; other site
697281000511	Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991
697281000512	active site
697281000513	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281000514	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281000515	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281000516	DNA binding site [nucleotide binding]
697281000517	domain linker motif; other site
697281000518	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281000519	dimerization interface [polypeptide binding]; other site
697281000520	ligand binding site [chemical binding]; other site
697281000521	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
697281000522	beta-D-glucuronidase; Provisional; Region: PRK10150
697281000523	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
697281000524	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
697281000525	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
697281000526	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
697281000527	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281000528	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281000529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000530	dimer interface [polypeptide binding]; other site
697281000531	conserved gate region; other site
697281000532	putative PBP binding loops; other site
697281000533	ABC-ATPase subunit interface; other site
697281000534	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281000535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000536	dimer interface [polypeptide binding]; other site
697281000537	conserved gate region; other site
697281000538	putative PBP binding loops; other site
697281000539	ABC-ATPase subunit interface; other site
697281000540	Helix-turn-helix domain; Region: HTH_28; pfam13518
697281000541	Winged helix-turn helix; Region: HTH_29; pfam13551
697281000542	Homeodomain-like domain; Region: HTH_32; pfam13565
697281000543	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
697281000544	Integrase core domain; Region: rve; pfam00665
697281000545	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
697281000546	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281000547	dimerization interface [polypeptide binding]; other site
697281000548	Histidine kinase; Region: His_kinase; pfam06580
697281000549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281000550	ATP binding site [chemical binding]; other site
697281000551	Mg2+ binding site [ion binding]; other site
697281000552	G-X-G motif; other site
697281000553	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
697281000554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281000555	active site
697281000556	phosphorylation site [posttranslational modification]
697281000557	intermolecular recognition site; other site
697281000558	dimerization interface [polypeptide binding]; other site
697281000559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281000560	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281000561	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281000562	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281000563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000564	dimer interface [polypeptide binding]; other site
697281000565	conserved gate region; other site
697281000566	putative PBP binding loops; other site
697281000567	ABC-ATPase subunit interface; other site
697281000568	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281000569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281000570	dimer interface [polypeptide binding]; other site
697281000571	conserved gate region; other site
697281000572	ABC-ATPase subunit interface; other site
697281000573	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
697281000574	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
697281000575	beta-D-glucuronidase; Provisional; Region: PRK10150
697281000576	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
697281000577	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
697281000578	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
697281000579	active site
697281000580	NTP binding site [chemical binding]; other site
697281000581	metal binding triad [ion binding]; metal-binding site
697281000582	antibiotic binding site [chemical binding]; other site
697281000583	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
697281000584	nucleotide binding site/active site [active]
697281000585	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
697281000586	HIT family signature motif; other site
697281000587	catalytic residue [active]
697281000588	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205
697281000589	PLD-like domain; Region: PLDc_2; pfam13091
697281000590	putative homodimer interface [polypeptide binding]; other site
697281000591	putative active site [active]
697281000592	catalytic site [active]
697281000593	DEAD-like helicases superfamily; Region: DEXDc; smart00487
697281000594	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
697281000595	ATP binding site [chemical binding]; other site
697281000596	putative Mg++ binding site [ion binding]; other site
697281000597	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
697281000598	nucleotide binding region [chemical binding]; other site
697281000599	ATP-binding site [chemical binding]; other site
697281000600	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
697281000601	The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465
697281000602	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
697281000603	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
697281000604	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
697281000605	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
697281000606	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
697281000607	homodimer interface [polypeptide binding]; other site
697281000608	substrate-cofactor binding pocket; other site
697281000609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281000610	catalytic residue [active]
697281000611	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
697281000612	6-phosphogluconate dehydratase; Region: edd; TIGR01196
697281000613	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
697281000614	catalytic core [active]
697281000615	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
697281000616	Uncharacterized conserved protein [Function unknown]; Region: COG1284
697281000617	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
697281000618	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
697281000619	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
697281000620	Tetratricopeptide repeat; Region: TPR_12; pfam13424
697281000621	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
697281000622	TPR motif; other site
697281000623	binding surface
697281000624	Tetratricopeptide repeat; Region: TPR_12; pfam13424
697281000625	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
697281000626	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
697281000627	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
697281000628	active site
697281000629	dimer interface [polypeptide binding]; other site
697281000630	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
697281000631	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
697281000632	oligomer interface [polypeptide binding]; other site
697281000633	metal binding site [ion binding]; metal-binding site
697281000634	metal binding site [ion binding]; metal-binding site
697281000635	putative Cl binding site [ion binding]; other site
697281000636	aspartate ring; other site
697281000637	basic sphincter; other site
697281000638	hydrophobic gate; other site
697281000639	periplasmic entrance; other site
697281000640	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281000641	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281000642	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281000643	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
697281000644	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
697281000645	active site
697281000646	SUMO-1 interface [polypeptide binding]; other site
697281000647	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
697281000648	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
697281000649	catalytic loop [active]
697281000650	iron binding site [ion binding]; other site
697281000651	seryl-tRNA synthetase; Provisional; Region: PRK05431
697281000652	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
697281000653	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
697281000654	dimer interface [polypeptide binding]; other site
697281000655	active site
697281000656	motif 1; other site
697281000657	motif 2; other site
697281000658	motif 3; other site
697281000659	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
697281000660	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281000661	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281000662	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281000663	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
697281000664	active site
697281000665	catalytic triad [active]
697281000666	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
697281000667	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
697281000668	active site
697281000669	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281000670	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281000671	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281000672	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281000673	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
697281000674	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
697281000675	Walker A/P-loop; other site
697281000676	ATP binding site [chemical binding]; other site
697281000677	Q-loop/lid; other site
697281000678	ABC transporter signature motif; other site
697281000679	Walker B; other site
697281000680	D-loop; other site
697281000681	H-loop/switch region; other site
697281000682	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281000683	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
697281000684	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
697281000685	Walker A/P-loop; other site
697281000686	ATP binding site [chemical binding]; other site
697281000687	Q-loop/lid; other site
697281000688	ABC transporter signature motif; other site
697281000689	Walker B; other site
697281000690	D-loop; other site
697281000691	H-loop/switch region; other site
697281000692	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
697281000693	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
697281000694	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
697281000695	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281000696	FeS/SAM binding site; other site
697281000697	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
697281000698	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
697281000699	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
697281000700	ligand binding site [chemical binding]; other site
697281000701	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
697281000702	putative switch regulator; other site
697281000703	non-specific DNA interactions [nucleotide binding]; other site
697281000704	DNA binding site [nucleotide binding]
697281000705	sequence specific DNA binding site [nucleotide binding]; other site
697281000706	putative cAMP binding site [chemical binding]; other site
697281000707	hybrid cluster protein; Provisional; Region: PRK05290
697281000708	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
697281000709	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
697281000710	hybrid metal cluster; other site
697281000711	Helix-turn-helix domain; Region: HTH_28; pfam13518
697281000712	Winged helix-turn helix; Region: HTH_29; pfam13551
697281000713	Integrase core domain; Region: rve; pfam00665
697281000714	Integrase core domain; Region: rve_3; cl15866
697281000715	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
697281000716	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
697281000717	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
697281000718	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
697281000719	S-adenosylmethionine binding site [chemical binding]; other site
697281000720	peptide chain release factor 1; Validated; Region: prfA; PRK00591
697281000721	This domain is found in peptide chain release factors; Region: PCRF; smart00937
697281000722	RF-1 domain; Region: RF-1; pfam00472
697281000723	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
697281000724	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
697281000725	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
697281000726	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
697281000727	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
697281000728	active site
697281000729	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
697281000730	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
697281000731	transmembrane helices; other site
697281000732	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
697281000733	catalytic motif [active]
697281000734	Zn binding site [ion binding]; other site
697281000735	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
697281000736	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
697281000737	active site
697281000738	homodimer interface [polypeptide binding]; other site
697281000739	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
697281000740	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
697281000741	intersubunit interface [polypeptide binding]; other site
697281000742	active site
697281000743	zinc binding site [ion binding]; other site
697281000744	Na+ binding site [ion binding]; other site
697281000745	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
697281000746	active site
697281000747	intersubunit interactions; other site
697281000748	catalytic residue [active]
697281000749	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
697281000750	transcription termination factor Rho; Provisional; Region: PRK12608
697281000751	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
697281000752	RNA binding site [nucleotide binding]; other site
697281000753	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
697281000754	multimer interface [polypeptide binding]; other site
697281000755	Walker A motif; other site
697281000756	ATP binding site [chemical binding]; other site
697281000757	Walker B motif; other site
697281000758	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
697281000759	Fe-S cluster binding site [ion binding]; other site
697281000760	active site
697281000761	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
697281000762	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
697281000763	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
697281000764	FAD binding site [chemical binding]; other site
697281000765	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
697281000766	MgtC family; Region: MgtC; pfam02308
697281000767	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
697281000768	histidinol-phosphatase; Provisional; Region: PRK05588
697281000769	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
697281000770	active site
697281000771	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
697281000772	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
697281000773	oligomer interface [polypeptide binding]; other site
697281000774	putative active site [active]
697281000775	metal binding site [ion binding]; metal-binding site
697281000776	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
697281000777	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
697281000778	dimer interface [polypeptide binding]; other site
697281000779	motif 1; other site
697281000780	active site
697281000781	motif 2; other site
697281000782	motif 3; other site
697281000783	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
697281000784	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
697281000785	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
697281000786	histidinol dehydrogenase; Region: hisD; TIGR00069
697281000787	NAD binding site [chemical binding]; other site
697281000788	dimerization interface [polypeptide binding]; other site
697281000789	product binding site; other site
697281000790	substrate binding site [chemical binding]; other site
697281000791	zinc binding site [ion binding]; other site
697281000792	catalytic residues [active]
697281000793	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
697281000794	putative active site pocket [active]
697281000795	4-fold oligomerization interface [polypeptide binding]; other site
697281000796	metal binding residues [ion binding]; metal-binding site
697281000797	3-fold/trimer interface [polypeptide binding]; other site
697281000798	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
697281000799	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
697281000800	putative active site [active]
697281000801	oxyanion strand; other site
697281000802	catalytic triad [active]
697281000803	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
697281000804	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
697281000805	catalytic residues [active]
697281000806	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
697281000807	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
697281000808	substrate binding site [chemical binding]; other site
697281000809	glutamase interaction surface [polypeptide binding]; other site
697281000810	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
697281000811	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
697281000812	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
697281000813	metal binding site [ion binding]; metal-binding site
697281000814	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
697281000815	Ligand Binding Site [chemical binding]; other site
697281000816	Short C-terminal domain; Region: SHOCT; pfam09851
697281000817	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
697281000818	putative homodimer interface [polypeptide binding]; other site
697281000819	putative homotetramer interface [polypeptide binding]; other site
697281000820	putative allosteric switch controlling residues; other site
697281000821	putative metal binding site [ion binding]; other site
697281000822	putative homodimer-homodimer interface [polypeptide binding]; other site
697281000823	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
697281000824	catalytic residues [active]
697281000825	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
697281000826	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
697281000827	HTH domain; Region: HTH_11; cl17392
697281000828	WYL domain; Region: WYL; pfam13280
697281000829	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
697281000830	binding surface
697281000831	TPR motif; other site
697281000832	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
697281000833	TPR motif; other site
697281000834	binding surface
697281000835	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
697281000836	binding surface
697281000837	TPR motif; other site
697281000838	Tetratricopeptide repeat; Region: TPR_16; pfam13432
697281000839	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
697281000840	dimer interface [polypeptide binding]; other site
697281000841	motif 1; other site
697281000842	active site
697281000843	motif 2; other site
697281000844	motif 3; other site
697281000845	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
697281000846	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
697281000847	pyruvate phosphate dikinase; Provisional; Region: PRK09279
697281000848	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
697281000849	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
697281000850	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
697281000851	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
697281000852	Penicillinase repressor; Region: Pencillinase_R; pfam03965
697281000853	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
697281000854	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
697281000855	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
697281000856	DNA binding residues [nucleotide binding]
697281000857	dimerization interface [polypeptide binding]; other site
697281000858	KWG Leptospira; Region: KWG; pfam07656
697281000859	KWG Leptospira; Region: KWG; pfam07656
697281000860	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
697281000861	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
697281000862	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
697281000863	Zn2+ binding site [ion binding]; other site
697281000864	Mg2+ binding site [ion binding]; other site
697281000865	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
697281000866	DNA primase; Validated; Region: dnaG; PRK05667
697281000867	CHC2 zinc finger; Region: zf-CHC2; pfam01807
697281000868	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
697281000869	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
697281000870	active site
697281000871	metal binding site [ion binding]; metal-binding site
697281000872	interdomain interaction site; other site
697281000873	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
697281000874	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
697281000875	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
697281000876	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
697281000877	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
697281000878	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281000879	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
697281000880	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281000881	DNA binding residues [nucleotide binding]
697281000882	Uncharacterized conserved protein [Function unknown]; Region: COG0327
697281000883	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
697281000884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
697281000885	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
697281000886	Uncharacterized conserved protein [Function unknown]; Region: COG0327
697281000887	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
697281000888	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
697281000889	Putative zinc ribbon domain; Region: DUF164; pfam02591
697281000890	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
697281000891	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
697281000892	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
697281000893	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281000894	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
697281000895	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
697281000896	Walker A/P-loop; other site
697281000897	ATP binding site [chemical binding]; other site
697281000898	Q-loop/lid; other site
697281000899	ABC transporter signature motif; other site
697281000900	Walker B; other site
697281000901	D-loop; other site
697281000902	H-loop/switch region; other site
697281000903	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281000904	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
697281000905	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281000906	Walker A/P-loop; other site
697281000907	ATP binding site [chemical binding]; other site
697281000908	Q-loop/lid; other site
697281000909	ABC transporter signature motif; other site
697281000910	Walker B; other site
697281000911	D-loop; other site
697281000912	H-loop/switch region; other site
697281000913	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
697281000914	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
697281000915	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
697281000916	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
697281000917	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
697281000918	putative active site [active]
697281000919	putative metal binding site [ion binding]; other site
697281000920	Protein of unknown function DUF86; Region: DUF86; pfam01934
697281000921	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
697281000922	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
697281000923	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
697281000924	NAD(P) binding site [chemical binding]; other site
697281000925	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
697281000926	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
697281000927	dimer interface [polypeptide binding]; other site
697281000928	putative CheW interface [polypeptide binding]; other site
697281000929	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
697281000930	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
697281000931	active site
697281000932	catalytic residues [active]
697281000933	metal binding site [ion binding]; metal-binding site
697281000934	aconitate hydratase; Validated; Region: PRK07229
697281000935	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
697281000936	substrate binding site [chemical binding]; other site
697281000937	ligand binding site [chemical binding]; other site
697281000938	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
697281000939	substrate binding site [chemical binding]; other site
697281000940	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
697281000941	isocitrate dehydrogenase; Validated; Region: PRK06451
697281000942	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
697281000943	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
697281000944	NAD(P) binding site [chemical binding]; other site
697281000945	homodimer interface [polypeptide binding]; other site
697281000946	substrate binding site [chemical binding]; other site
697281000947	active site
697281000948	Transcriptional regulator [Transcription]; Region: LytR; COG1316
697281000949	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281000950	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281000951	DNA binding site [nucleotide binding]
697281000952	domain linker motif; other site
697281000953	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281000954	dimerization interface [polypeptide binding]; other site
697281000955	ligand binding site [chemical binding]; other site
697281000956	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281000957	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281000958	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281000959	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
697281000960	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
697281000961	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
697281000962	active site
697281000963	metal binding site [ion binding]; metal-binding site
697281000964	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
697281000965	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
697281000966	homotetramer interface [polypeptide binding]; other site
697281000967	ligand binding site [chemical binding]; other site
697281000968	catalytic site [active]
697281000969	NAD binding site [chemical binding]; other site
697281000970	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
697281000971	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
697281000972	active site
697281000973	putative substrate binding pocket [chemical binding]; other site
697281000974	dipeptidase PepV; Reviewed; Region: PRK07318
697281000975	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
697281000976	active site
697281000977	metal binding site [ion binding]; metal-binding site
697281000978	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
697281000979	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
697281000980	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
697281000981	hinge; other site
697281000982	active site
697281000983	rod shape-determining protein Mbl; Provisional; Region: PRK13928
697281000984	MreB and similar proteins; Region: MreB_like; cd10225
697281000985	nucleotide binding site [chemical binding]; other site
697281000986	Mg binding site [ion binding]; other site
697281000987	putative protofilament interaction site [polypeptide binding]; other site
697281000988	RodZ interaction site [polypeptide binding]; other site
697281000989	Stage III sporulation protein D; Region: SpoIIID; pfam12116
697281000990	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
697281000991	Peptidase family M23; Region: Peptidase_M23; pfam01551
697281000992	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818
697281000993	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
697281000994	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
697281000995	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
697281000996	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
697281000997	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281000998	AAA domain; Region: AAA_23; pfam13476
697281000999	Walker A/P-loop; other site
697281001000	ATP binding site [chemical binding]; other site
697281001001	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
697281001002	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
697281001003	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
697281001004	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
697281001005	active site
697281001006	metal binding site [ion binding]; metal-binding site
697281001007	DNA binding site [nucleotide binding]
697281001008	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
697281001009	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281001010	dimerization interface [polypeptide binding]; other site
697281001011	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
697281001012	dimer interface [polypeptide binding]; other site
697281001013	phosphorylation site [posttranslational modification]
697281001014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281001015	ATP binding site [chemical binding]; other site
697281001016	Mg2+ binding site [ion binding]; other site
697281001017	G-X-G motif; other site
697281001018	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
697281001019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281001020	active site
697281001021	phosphorylation site [posttranslational modification]
697281001022	intermolecular recognition site; other site
697281001023	dimerization interface [polypeptide binding]; other site
697281001024	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
697281001025	DNA binding site [nucleotide binding]
697281001026	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
697281001027	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
697281001028	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
697281001029	Probable transposase; Region: OrfB_IS605; pfam01385
697281001030	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
697281001031	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
697281001032	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
697281001033	tetramer interface [polypeptide binding]; other site
697281001034	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281001035	catalytic residue [active]
697281001036	putative transporter; Provisional; Region: PRK10504
697281001037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
697281001038	putative substrate translocation pore; other site
697281001039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
697281001040	putative substrate translocation pore; other site
697281001041	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
697281001042	Mechanosensitive ion channel; Region: MS_channel; pfam00924
697281001043	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
697281001044	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
697281001045	inhibitor-cofactor binding pocket; inhibition site
697281001046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281001047	catalytic residue [active]
697281001048	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
697281001049	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
697281001050	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
697281001051	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281001052	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281001053	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281001054	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
697281001055	putative trimer interface [polypeptide binding]; other site
697281001056	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
697281001057	putative trimer interface [polypeptide binding]; other site
697281001058	putative active site [active]
697281001059	putative substrate binding site [chemical binding]; other site
697281001060	putative CoA binding site [chemical binding]; other site
697281001061	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
697281001062	O-Antigen ligase; Region: Wzy_C; pfam04932
697281001063	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
697281001064	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
697281001065	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
697281001066	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
697281001067	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
697281001068	active site
697281001069	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
697281001070	homodimer interface [polypeptide binding]; other site
697281001071	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
697281001072	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
697281001073	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
697281001074	putative trimer interface [polypeptide binding]; other site
697281001075	putative CoA binding site [chemical binding]; other site
697281001076	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
697281001077	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
697281001078	inhibitor-cofactor binding pocket; inhibition site
697281001079	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281001080	catalytic residue [active]
697281001081	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
697281001082	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
697281001083	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
697281001084	aspartate aminotransferase; Provisional; Region: PRK06290
697281001085	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
697281001086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281001087	homodimer interface [polypeptide binding]; other site
697281001088	catalytic residue [active]
697281001089	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
697281001090	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
697281001091	homodimer interface [polypeptide binding]; other site
697281001092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281001093	catalytic residue [active]
697281001094	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
697281001095	thymidylate kinase; Validated; Region: tmk; PRK00698
697281001096	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
697281001097	TMP-binding site; other site
697281001098	ATP-binding site [chemical binding]; other site
697281001099	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
697281001100	O-Antigen ligase; Region: Wzy_C; pfam04932
697281001101	Protein of unknown function (DUF970); Region: DUF970; cl17525
697281001102	Protein of unknown function (DUF327); Region: DUF327; pfam03885
697281001103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281001104	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
697281001105	Walker A motif; other site
697281001106	ATP binding site [chemical binding]; other site
697281001107	Walker B motif; other site
697281001108	arginine finger; other site
697281001109	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
697281001110	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
697281001111	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
697281001112	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
697281001113	putative NAD(P) binding site [chemical binding]; other site
697281001114	catalytic Zn binding site [ion binding]; other site
697281001115	Stage II sporulation protein; Region: SpoIID; pfam08486
697281001116	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
697281001117	Bacterial SH3 domain; Region: SH3_3; pfam08239
697281001118	Bacterial SH3 domain; Region: SH3_3; pfam08239
697281001119	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
697281001120	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
697281001121	CoA binding domain; Region: CoA_binding; smart00881
697281001122	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
697281001123	PRC-barrel domain; Region: PRC; pfam05239
697281001124	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
697281001125	VanW like protein; Region: VanW; pfam04294
697281001126	G5 domain; Region: G5; pfam07501
697281001127	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
697281001128	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
697281001129	AsnC family; Region: AsnC_trans_reg; pfam01037
697281001130	hypothetical protein; Validated; Region: PRK07682
697281001131	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
697281001132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281001133	homodimer interface [polypeptide binding]; other site
697281001134	catalytic residue [active]
697281001135	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
697281001136	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
697281001137	FMN binding site [chemical binding]; other site
697281001138	substrate binding site [chemical binding]; other site
697281001139	putative catalytic residue [active]
697281001140	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
697281001141	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
697281001142	hexamer (dimer of trimers) interface [polypeptide binding]; other site
697281001143	substrate binding site [chemical binding]; other site
697281001144	trimer interface [polypeptide binding]; other site
697281001145	Mn binding site [ion binding]; other site
697281001146	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
697281001147	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
697281001148	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281001149	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
697281001150	Walker A motif; other site
697281001151	ATP binding site [chemical binding]; other site
697281001152	Walker B motif; other site
697281001153	arginine finger; other site
697281001154	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
697281001155	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
697281001156	gamma subunit interface [polypeptide binding]; other site
697281001157	epsilon subunit interface [polypeptide binding]; other site
697281001158	LBP interface [polypeptide binding]; other site
697281001159	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
697281001160	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
697281001161	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
697281001162	alpha subunit interaction interface [polypeptide binding]; other site
697281001163	Walker A motif; other site
697281001164	ATP binding site [chemical binding]; other site
697281001165	Walker B motif; other site
697281001166	inhibitor binding site; inhibition site
697281001167	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
697281001168	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
697281001169	core domain interface [polypeptide binding]; other site
697281001170	delta subunit interface [polypeptide binding]; other site
697281001171	epsilon subunit interface [polypeptide binding]; other site
697281001172	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
697281001173	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
697281001174	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
697281001175	beta subunit interaction interface [polypeptide binding]; other site
697281001176	Walker A motif; other site
697281001177	ATP binding site [chemical binding]; other site
697281001178	Walker B motif; other site
697281001179	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
697281001180	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
697281001181	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
697281001182	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
697281001183	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
697281001184	ATP synthase subunit C; Region: ATP-synt_C; cl00466
697281001185	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
697281001186	Helix-turn-helix domain; Region: HTH_28; pfam13518
697281001187	Winged helix-turn helix; Region: HTH_29; pfam13551
697281001188	Integrase core domain; Region: rve; pfam00665
697281001189	Integrase core domain; Region: rve_3; cl15866
697281001190	Domain of unknown function (DUF377); Region: DUF377; pfam04041
697281001191	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
697281001192	active site
697281001193	GTP-binding protein YchF; Reviewed; Region: PRK09601
697281001194	YchF GTPase; Region: YchF; cd01900
697281001195	G1 box; other site
697281001196	GTP/Mg2+ binding site [chemical binding]; other site
697281001197	Switch I region; other site
697281001198	G2 box; other site
697281001199	Switch II region; other site
697281001200	G3 box; other site
697281001201	G4 box; other site
697281001202	G5 box; other site
697281001203	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
697281001204	SWIM zinc finger; Region: SWIM; pfam04434
697281001205	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
697281001206	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
697281001207	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
697281001208	ATP binding site [chemical binding]; other site
697281001209	putative Mg++ binding site [ion binding]; other site
697281001210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
697281001211	nucleotide binding region [chemical binding]; other site
697281001212	ATP-binding site [chemical binding]; other site
697281001213	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
697281001214	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
697281001215	Predicted transcriptional regulator [Transcription]; Region: COG3432
697281001216	glycerate kinase; Region: TIGR00045
697281001217	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
697281001218	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
697281001219	anti sigma factor interaction site; other site
697281001220	regulatory phosphorylation site [posttranslational modification]; other site
697281001221	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
697281001222	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281001223	ATP binding site [chemical binding]; other site
697281001224	Mg2+ binding site [ion binding]; other site
697281001225	G-X-G motif; other site
697281001226	sporulation sigma factor SigF; Validated; Region: PRK05572
697281001227	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281001228	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
697281001229	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281001230	DNA binding residues [nucleotide binding]
697281001231	FMN-binding domain; Region: FMN_bind; cl01081
697281001232	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
697281001233	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
697281001234	dimer interface [polypeptide binding]; other site
697281001235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281001236	catalytic residue [active]
697281001237	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281001238	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281001239	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
697281001240	Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231
697281001241	catalytic Zn binding site [ion binding]; other site
697281001242	structural Zn binding site [ion binding]; other site
697281001243	tetramer interface [polypeptide binding]; other site
697281001244	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281001245	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281001246	DNA binding site [nucleotide binding]
697281001247	domain linker motif; other site
697281001248	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281001249	dimerization interface [polypeptide binding]; other site
697281001250	ligand binding site [chemical binding]; other site
697281001251	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
697281001252	L-aspartate oxidase; Provisional; Region: PRK06175
697281001253	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
697281001254	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
697281001255	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
697281001256	phosphate binding site [ion binding]; other site
697281001257	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
697281001258	4Fe-4S binding domain; Region: Fer4; pfam00037
697281001259	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
697281001260	active site
697281001261	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
697281001262	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
697281001263	active site
697281001264	catalytic tetrad [active]
697281001265	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
697281001266	Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133
697281001267	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
697281001268	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
697281001269	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
697281001270	GDP-binding site [chemical binding]; other site
697281001271	ACT binding site; other site
697281001272	IMP binding site; other site
697281001273	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
697281001274	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
697281001275	dimer interface [polypeptide binding]; other site
697281001276	phosphorylation site [posttranslational modification]
697281001277	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281001278	ATP binding site [chemical binding]; other site
697281001279	Mg2+ binding site [ion binding]; other site
697281001280	G-X-G motif; other site
697281001281	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
697281001282	Zn binding site [ion binding]; other site
697281001283	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
697281001284	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
697281001285	G5 domain; Region: G5; pfam07501
697281001286	Peptidase family M23; Region: Peptidase_M23; pfam01551
697281001287	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
697281001288	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
697281001289	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
697281001290	DNA binding site [nucleotide binding]
697281001291	active site
697281001292	YtxC-like family; Region: YtxC; pfam08812
697281001293	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
697281001294	Predicted dehydrogenase [General function prediction only]; Region: COG0579
697281001295	hydroxyglutarate oxidase; Provisional; Region: PRK11728
697281001296	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
697281001297	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
697281001298	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
697281001299	Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862
697281001300	Uncharacterized conserved protein [Function unknown]; Region: COG1683
697281001301	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
697281001302	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
697281001303	Protein of unknown function (DUF632); Region: DUF632; pfam04782
697281001304	HlyD family secretion protein; Region: HlyD_3; pfam13437
697281001305	FtsX-like permease family; Region: FtsX; pfam02687
697281001306	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
697281001307	stage V sporulation protein B; Region: spore_V_B; TIGR02900
697281001308	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
697281001309	biotin synthase; Provisional; Region: PRK07094
697281001310	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281001311	FeS/SAM binding site; other site
697281001312	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
697281001313	Methyltransferase domain; Region: Methyltransf_31; pfam13847
697281001314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
697281001315	S-adenosylmethionine binding site [chemical binding]; other site
697281001316	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
697281001317	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
697281001318	UvrB/uvrC motif; Region: UVR; pfam02151
697281001319	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
697281001320	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
697281001321	ADP binding site [chemical binding]; other site
697281001322	phosphagen binding site; other site
697281001323	substrate specificity loop; other site
697281001324	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
697281001325	Clp amino terminal domain; Region: Clp_N; pfam02861
697281001326	Clp amino terminal domain; Region: Clp_N; pfam02861
697281001327	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281001328	Walker A motif; other site
697281001329	ATP binding site [chemical binding]; other site
697281001330	Walker B motif; other site
697281001331	arginine finger; other site
697281001332	UvrB/uvrC motif; Region: UVR; pfam02151
697281001333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281001334	Walker A motif; other site
697281001335	ATP binding site [chemical binding]; other site
697281001336	Walker B motif; other site
697281001337	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
697281001338	DNA repair protein RadA; Provisional; Region: PRK11823
697281001339	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
697281001340	Walker A motif/ATP binding site; other site
697281001341	ATP binding site [chemical binding]; other site
697281001342	Walker B motif; other site
697281001343	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
697281001344	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
697281001345	metal binding site [ion binding]; metal-binding site
697281001346	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
697281001347	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281001348	Walker A motif; other site
697281001349	ATP binding site [chemical binding]; other site
697281001350	Walker B motif; other site
697281001351	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
697281001352	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
697281001353	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
697281001354	putative active site [active]
697281001355	putative NTP binding site [chemical binding]; other site
697281001356	putative nucleic acid binding site [nucleotide binding]; other site
697281001357	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
697281001358	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281001359	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
697281001360	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
697281001361	Walker A/P-loop; other site
697281001362	ATP binding site [chemical binding]; other site
697281001363	Q-loop/lid; other site
697281001364	ABC transporter signature motif; other site
697281001365	Walker B; other site
697281001366	D-loop; other site
697281001367	H-loop/switch region; other site
697281001368	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
697281001369	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281001370	non-specific DNA binding site [nucleotide binding]; other site
697281001371	salt bridge; other site
697281001372	sequence-specific DNA binding site [nucleotide binding]; other site
697281001373	Nitroreductase family; Region: Nitroreductase; pfam00881
697281001374	FMN binding site [chemical binding]; other site
697281001375	dimer interface [polypeptide binding]; other site
697281001376	NAD synthetase; Provisional; Region: PRK13981
697281001377	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
697281001378	multimer interface [polypeptide binding]; other site
697281001379	active site
697281001380	catalytic triad [active]
697281001381	protein interface 1 [polypeptide binding]; other site
697281001382	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
697281001383	homodimer interface [polypeptide binding]; other site
697281001384	NAD binding pocket [chemical binding]; other site
697281001385	ATP binding pocket [chemical binding]; other site
697281001386	Mg binding site [ion binding]; other site
697281001387	active-site loop [active]
697281001388	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
697281001389	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
697281001390	active site
697281001391	catalytic tetrad [active]
697281001392	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
697281001393	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
697281001394	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
697281001395	intersubunit interface [polypeptide binding]; other site
697281001396	active site
697281001397	Zn2+ binding site [ion binding]; other site
697281001398	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281001399	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281001400	HAMP domain; Region: HAMP; pfam00672
697281001401	dimerization interface [polypeptide binding]; other site
697281001402	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
697281001403	Histidine kinase; Region: His_kinase; pfam06580
697281001404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281001405	ATP binding site [chemical binding]; other site
697281001406	Mg2+ binding site [ion binding]; other site
697281001407	G-X-G motif; other site
697281001408	Response regulator receiver domain; Region: Response_reg; pfam00072
697281001409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281001410	active site
697281001411	phosphorylation site [posttranslational modification]
697281001412	intermolecular recognition site; other site
697281001413	dimerization interface [polypeptide binding]; other site
697281001414	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281001415	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281001416	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281001417	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
697281001418	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
697281001419	putative metal binding site [ion binding]; other site
697281001420	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281001421	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281001422	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281001423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
697281001424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281001425	dimer interface [polypeptide binding]; other site
697281001426	conserved gate region; other site
697281001427	putative PBP binding loops; other site
697281001428	ABC-ATPase subunit interface; other site
697281001429	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281001430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281001431	dimer interface [polypeptide binding]; other site
697281001432	conserved gate region; other site
697281001433	putative PBP binding loops; other site
697281001434	ABC-ATPase subunit interface; other site
697281001435	NHL repeat; Region: NHL; pfam01436
697281001436	NHL repeat; Region: NHL; pfam01436
697281001437	Tetratricopeptide repeat; Region: TPR_12; pfam13424
697281001438	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
697281001439	binding surface
697281001440	TPR motif; other site
697281001441	Yip1 domain; Region: Yip1; pfam04893
697281001442	transposase; Provisional; Region: PRK06526
697281001443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281001444	Walker A motif; other site
697281001445	ATP binding site [chemical binding]; other site
697281001446	Walker B motif; other site
697281001447	arginine finger; other site
697281001448	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281001449	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
697281001450	non-specific DNA binding site [nucleotide binding]; other site
697281001451	salt bridge; other site
697281001452	sequence-specific DNA binding site [nucleotide binding]; other site
697281001453	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
697281001454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281001455	ABC-ATPase subunit interface; other site
697281001456	putative PBP binding loops; other site
697281001457	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281001458	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281001459	dimer interface [polypeptide binding]; other site
697281001460	conserved gate region; other site
697281001461	ABC-ATPase subunit interface; other site
697281001462	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281001463	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281001464	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
697281001465	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
697281001466	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
697281001467	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281001468	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281001469	Walker A/P-loop; other site
697281001470	ATP binding site [chemical binding]; other site
697281001471	Q-loop/lid; other site
697281001472	ABC transporter signature motif; other site
697281001473	Walker B; other site
697281001474	D-loop; other site
697281001475	H-loop/switch region; other site
697281001476	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
697281001477	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
697281001478	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281001479	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281001480	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281001481	classical (c) SDRs; Region: SDR_c; cd05233
697281001482	NAD(P) binding site [chemical binding]; other site
697281001483	active site
697281001484	Transcriptional regulators [Transcription]; Region: FadR; COG2186
697281001485	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
697281001486	DNA-binding site [nucleotide binding]; DNA binding site
697281001487	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
697281001488	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
697281001489	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
697281001490	NAD(P) binding site [chemical binding]; other site
697281001491	transketolase; Reviewed; Region: PRK05899
697281001492	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
697281001493	TPP-binding site [chemical binding]; other site
697281001494	dimer interface [polypeptide binding]; other site
697281001495	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
697281001496	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
697281001497	PYR/PP interface [polypeptide binding]; other site
697281001498	dimer interface [polypeptide binding]; other site
697281001499	TPP binding site [chemical binding]; other site
697281001500	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
697281001501	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
697281001502	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
697281001503	GntP family permease; Region: GntP_permease; pfam02447
697281001504	fructuronate transporter; Provisional; Region: PRK10034; cl15264
697281001505	GntP family permease; Region: GntP_permease; pfam02447
697281001506	fructuronate transporter; Provisional; Region: PRK10034; cl15264
697281001507	Transcriptional regulator; Region: Rrf2; cl17282
697281001508	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281001509	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281001510	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281001511	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281001512	dimer interface [polypeptide binding]; other site
697281001513	conserved gate region; other site
697281001514	putative PBP binding loops; other site
697281001515	ABC-ATPase subunit interface; other site
697281001516	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281001517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281001518	dimer interface [polypeptide binding]; other site
697281001519	conserved gate region; other site
697281001520	ABC-ATPase subunit interface; other site
697281001521	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281001522	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281001523	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
697281001524	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
697281001525	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
697281001526	active site
697281001527	acyl-activating enzyme (AAE) consensus motif; other site
697281001528	putative CoA binding site [chemical binding]; other site
697281001529	AMP binding site [chemical binding]; other site
697281001530	AAA domain; Region: AAA_32; pfam13654
697281001531	ATP-dependent protease Lon; Provisional; Region: PRK13765
697281001532	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
697281001533	peroxiredoxin; Provisional; Region: PRK13189
697281001534	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
697281001535	dimer interface [polypeptide binding]; other site
697281001536	decamer (pentamer of dimers) interface [polypeptide binding]; other site
697281001537	catalytic triad [active]
697281001538	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
697281001539	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
697281001540	NAD binding site [chemical binding]; other site
697281001541	dimer interface [polypeptide binding]; other site
697281001542	substrate binding site [chemical binding]; other site
697281001543	tetramer (dimer of dimers) interface [polypeptide binding]; other site
697281001544	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
697281001545	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
697281001546	Walker A/P-loop; other site
697281001547	ATP binding site [chemical binding]; other site
697281001548	Q-loop/lid; other site
697281001549	ABC transporter signature motif; other site
697281001550	Walker B; other site
697281001551	D-loop; other site
697281001552	H-loop/switch region; other site
697281001553	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
697281001554	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
697281001555	Walker A/P-loop; other site
697281001556	ATP binding site [chemical binding]; other site
697281001557	Q-loop/lid; other site
697281001558	ABC transporter signature motif; other site
697281001559	Walker B; other site
697281001560	D-loop; other site
697281001561	H-loop/switch region; other site
697281001562	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
697281001563	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
697281001564	TM-ABC transporter signature motif; other site
697281001565	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
697281001566	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
697281001567	TM-ABC transporter signature motif; other site
697281001568	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
697281001569	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
697281001570	putative ligand binding site [chemical binding]; other site
697281001571	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
697281001572	Accessory gene regulator B; Region: AgrB; pfam04647
697281001573	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
697281001574	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281001575	FeS/SAM binding site; other site
697281001576	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
697281001577	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
697281001578	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
697281001579	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
697281001580	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
697281001581	Part of AAA domain; Region: AAA_19; pfam13245
697281001582	Family description; Region: UvrD_C_2; pfam13538
697281001583	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
697281001584	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
697281001585	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
697281001586	Walker A/P-loop; other site
697281001587	ATP binding site [chemical binding]; other site
697281001588	Q-loop/lid; other site
697281001589	ABC transporter signature motif; other site
697281001590	Walker B; other site
697281001591	D-loop; other site
697281001592	H-loop/switch region; other site
697281001593	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
697281001594	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
697281001595	binding surface
697281001596	TPR motif; other site
697281001597	TPR repeat; Region: TPR_11; pfam13414
697281001598	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
697281001599	active site
697281001600	intracellular protease, PfpI family; Region: PfpI; TIGR01382
697281001601	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
697281001602	proposed catalytic triad [active]
697281001603	conserved cys residue [active]
697281001604	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
697281001605	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
697281001606	HIGH motif; other site
697281001607	active site
697281001608	KMSKS motif; other site
697281001609	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
697281001610	tRNA binding surface [nucleotide binding]; other site
697281001611	anticodon binding site; other site
697281001612	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
697281001613	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
697281001614	active site
697281001615	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
697281001616	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281001617	FeS/SAM binding site; other site
697281001618	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
697281001619	Protein of unknown function (DUF503); Region: DUF503; pfam04456
697281001620	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
697281001621	anthranilate synthase component I; Provisional; Region: PRK13570
697281001622	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
697281001623	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
697281001624	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
697281001625	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
697281001626	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
697281001627	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
697281001628	active site
697281001629	ribulose/triose binding site [chemical binding]; other site
697281001630	phosphate binding site [ion binding]; other site
697281001631	substrate (anthranilate) binding pocket [chemical binding]; other site
697281001632	product (indole) binding pocket [chemical binding]; other site
697281001633	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
697281001634	active site
697281001635	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
697281001636	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
697281001637	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281001638	catalytic residue [active]
697281001639	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
697281001640	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
697281001641	substrate binding site [chemical binding]; other site
697281001642	active site
697281001643	catalytic residues [active]
697281001644	heterodimer interface [polypeptide binding]; other site
697281001645	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
697281001646	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
697281001647	Walker A/P-loop; other site
697281001648	ATP binding site [chemical binding]; other site
697281001649	Q-loop/lid; other site
697281001650	ABC transporter signature motif; other site
697281001651	Walker B; other site
697281001652	D-loop; other site
697281001653	H-loop/switch region; other site
697281001654	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
697281001655	HlyD family secretion protein; Region: HlyD_3; pfam13437
697281001656	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
697281001657	FtsX-like permease family; Region: FtsX; pfam02687
697281001658	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
697281001659	FtsX-like permease family; Region: FtsX; pfam02687
697281001660	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
697281001661	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
697281001662	Walker A/P-loop; other site
697281001663	ATP binding site [chemical binding]; other site
697281001664	Q-loop/lid; other site
697281001665	ABC transporter signature motif; other site
697281001666	Walker B; other site
697281001667	D-loop; other site
697281001668	H-loop/switch region; other site
697281001669	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
697281001670	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
697281001671	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
697281001672	Int/Topo IB signature motif; other site
697281001673	Domain of unknown function (DUF955); Region: DUF955; cl01076
697281001674	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281001675	non-specific DNA binding site [nucleotide binding]; other site
697281001676	salt bridge; other site
697281001677	sequence-specific DNA binding site [nucleotide binding]; other site
697281001678	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
697281001679	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281001680	non-specific DNA binding site [nucleotide binding]; other site
697281001681	salt bridge; other site
697281001682	sequence-specific DNA binding site [nucleotide binding]; other site
697281001683	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
697281001684	active site
697281001685	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281001686	non-specific DNA binding site [nucleotide binding]; other site
697281001687	salt bridge; other site
697281001688	sequence-specific DNA binding site [nucleotide binding]; other site
697281001689	MIF4G like; Region: MIF4G_like_2; pfam09090
697281001690	Helix-turn-helix domain; Region: HTH_17; cl17695
697281001691	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
697281001692	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
697281001693	replicative DNA helicase; Region: DnaB; TIGR00665
697281001694	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
697281001695	Orbivirus non-structural protein NS1, or hydrophobic tubular protein; Region: Orbi_NS1; pfam01718
697281001696	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
697281001697	Walker A motif; other site
697281001698	ATP binding site [chemical binding]; other site
697281001699	Walker B motif; other site
697281001700	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
697281001701	Protein of unknown function (DUF1492); Region: DUF1492; pfam07374
697281001702	Terminase small subunit; Region: Terminase_2; pfam03592
697281001703	DEAD-like helicases superfamily; Region: DEXDc; smart00487
697281001704	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
697281001705	Glutamyl-tRNA reductase [Coenzyme metabolism]; Region: HemA; COG0373
697281001706	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
697281001707	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
697281001708	Phage XkdN-like protein; Region: XkdN; pfam08890
697281001709	tape measure domain; Region: tape_meas_nterm; TIGR02675
697281001710	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
697281001711	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
697281001712	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
697281001713	Baseplate J-like protein; Region: Baseplate_J; pfam04865
697281001714	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
697281001715	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693
697281001716	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
697281001717	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
697281001718	active site
697281001719	metal binding site [ion binding]; metal-binding site
697281001720	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
697281001721	Integrase core domain; Region: rve; pfam00665
697281001722	Integrase core domain; Region: rve_3; cl15866
697281001723	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
697281001724	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
697281001725	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
697281001726	active site
697281001727	HIGH motif; other site
697281001728	KMSK motif region; other site
697281001729	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
697281001730	tRNA binding surface [nucleotide binding]; other site
697281001731	anticodon binding site; other site
697281001732	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
697281001733	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
697281001734	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
697281001735	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
697281001736	active site
697281001737	dimer interface [polypeptide binding]; other site
697281001738	motif 1; other site
697281001739	motif 2; other site
697281001740	motif 3; other site
697281001741	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
697281001742	anticodon binding site; other site
697281001743	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
697281001744	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
697281001745	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
697281001746	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
697281001747	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
697281001748	23S rRNA binding site [nucleotide binding]; other site
697281001749	L21 binding site [polypeptide binding]; other site
697281001750	L13 binding site [polypeptide binding]; other site
697281001751	stage II sporulation protein E; Region: spore_II_E; TIGR02865
697281001752	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
697281001753	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
697281001754	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
697281001755	metal ion-dependent adhesion site (MIDAS); other site
697281001756	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
697281001757	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
697281001758	active site
697281001759	ATP binding site [chemical binding]; other site
697281001760	substrate binding site [chemical binding]; other site
697281001761	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
697281001762	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
697281001763	Ligand Binding Site [chemical binding]; other site
697281001764	TilS substrate C-terminal domain; Region: TilS_C; smart00977
697281001765	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
697281001766	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
697281001767	active site
697281001768	FtsH Extracellular; Region: FtsH_ext; pfam06480
697281001769	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
697281001770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281001771	Walker A motif; other site
697281001772	ATP binding site [chemical binding]; other site
697281001773	Walker B motif; other site
697281001774	arginine finger; other site
697281001775	Peptidase family M41; Region: Peptidase_M41; pfam01434
697281001776	Predicted thioesterase [General function prediction only]; Region: COG5496
697281001777	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281001778	dimerization interface [polypeptide binding]; other site
697281001779	putative DNA binding site [nucleotide binding]; other site
697281001780	putative Zn2+ binding site [ion binding]; other site
697281001781	Uncharacterized conserved protein [Function unknown]; Region: COG0398
697281001782	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
697281001783	Uncharacterized conserved protein [Function unknown]; Region: COG0398
697281001784	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
697281001785	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
697281001786	V-type ATP synthase subunit I; Validated; Region: PRK05771
697281001787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
697281001788	putative substrate translocation pore; other site
697281001789	V-type ATP synthase subunit K; Validated; Region: PRK06558
697281001790	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
697281001791	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
697281001792	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
697281001793	V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074
697281001794	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
697281001795	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
697281001796	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632
697281001797	V-type ATP synthase subunit A; Provisional; Region: PRK14698
697281001798	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
697281001799	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
697281001800	Walker A motif; other site
697281001801	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
697281001802	protein-splicing catalytic site; other site
697281001803	thioester formation/cholesterol transfer; other site
697281001804	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
697281001805	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
697281001806	Walker A motif/ATP binding site; other site
697281001807	Walker B motif; other site
697281001808	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
697281001809	V-type ATP synthase subunit B; Provisional; Region: PRK04196
697281001810	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
697281001811	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
697281001812	Walker A motif homologous position; other site
697281001813	Walker B motif; other site
697281001814	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
697281001815	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
697281001816	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
697281001817	Protein of unknown function, DUF608; Region: DUF608; pfam04685
697281001818	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
697281001819	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
697281001820	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
697281001821	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
697281001822	putative active site [active]
697281001823	putative metal binding site [ion binding]; other site
697281001824	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281001825	Walker A/P-loop; other site
697281001826	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
697281001827	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
697281001828	FtsX-like permease family; Region: FtsX; pfam02687
697281001829	FtsX-like permease family; Region: FtsX; pfam02687
697281001830	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
697281001831	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
697281001832	Walker A/P-loop; other site
697281001833	ATP binding site [chemical binding]; other site
697281001834	Q-loop/lid; other site
697281001835	ABC transporter signature motif; other site
697281001836	Walker B; other site
697281001837	D-loop; other site
697281001838	H-loop/switch region; other site
697281001839	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
697281001840	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
697281001841	TPP-binding site [chemical binding]; other site
697281001842	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
697281001843	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
697281001844	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
697281001845	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
697281001846	dimer interface [polypeptide binding]; other site
697281001847	PYR/PP interface [polypeptide binding]; other site
697281001848	TPP binding site [chemical binding]; other site
697281001849	substrate binding site [chemical binding]; other site
697281001850	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
697281001851	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
697281001852	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
697281001853	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
697281001854	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
697281001855	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
697281001856	active site
697281001857	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
697281001858	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
697281001859	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
697281001860	MgtE intracellular N domain; Region: MgtE_N; smart00924
697281001861	FOG: CBS domain [General function prediction only]; Region: COG0517
697281001862	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
697281001863	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281001864	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281001865	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281001866	sugar efflux transporter; Region: 2A0120; TIGR00899
697281001867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
697281001868	putative substrate translocation pore; other site
697281001869	PrcB C-terminal; Region: PrcB_C; pfam14343
697281001870	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
697281001871	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
697281001872	Sensor protein DegS; Region: DegS; pfam05384
697281001873	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
697281001874	Histidine kinase; Region: HisKA_3; pfam07730
697281001875	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281001876	ATP binding site [chemical binding]; other site
697281001877	Mg2+ binding site [ion binding]; other site
697281001878	G-X-G motif; other site
697281001879	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
697281001880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281001881	active site
697281001882	phosphorylation site [posttranslational modification]
697281001883	intermolecular recognition site; other site
697281001884	dimerization interface [polypeptide binding]; other site
697281001885	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
697281001886	DNA binding residues [nucleotide binding]
697281001887	dimerization interface [polypeptide binding]; other site
697281001888	Predicted permeases [General function prediction only]; Region: COG0679
697281001889	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
697281001890	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
697281001891	Walker A/P-loop; other site
697281001892	ATP binding site [chemical binding]; other site
697281001893	Q-loop/lid; other site
697281001894	ABC transporter signature motif; other site
697281001895	Walker B; other site
697281001896	D-loop; other site
697281001897	H-loop/switch region; other site
697281001898	TOBE domain; Region: TOBE_2; pfam08402
697281001899	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
697281001900	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
697281001901	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281001902	Walker A/P-loop; other site
697281001903	ATP binding site [chemical binding]; other site
697281001904	Q-loop/lid; other site
697281001905	ABC transporter signature motif; other site
697281001906	Walker B; other site
697281001907	D-loop; other site
697281001908	H-loop/switch region; other site
697281001909	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
697281001910	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
697281001911	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
697281001912	Peptidase family M23; Region: Peptidase_M23; pfam01551
697281001913	phosphodiesterase; Provisional; Region: PRK12704
697281001914	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
697281001915	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
697281001916	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
697281001917	active site
697281001918	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
697281001919	aspartate aminotransferase; Provisional; Region: PRK05764
697281001920	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
697281001921	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281001922	homodimer interface [polypeptide binding]; other site
697281001923	catalytic residue [active]
697281001924	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
697281001925	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
697281001926	tetramer interface [polypeptide binding]; other site
697281001927	active site
697281001928	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
697281001929	homodimer interface [polypeptide binding]; other site
697281001930	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281001931	catalytic residue [active]
697281001932	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
697281001933	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
697281001934	ligand binding site [chemical binding]; other site
697281001935	NAD binding site [chemical binding]; other site
697281001936	dimerization interface [polypeptide binding]; other site
697281001937	catalytic site [active]
697281001938	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
697281001939	putative L-serine binding site [chemical binding]; other site
697281001940	YqzL-like protein; Region: YqzL; pfam14006
697281001941	Recombination protein O N terminal; Region: RecO_N; pfam11967
697281001942	DNA repair protein RecO; Region: reco; TIGR00613
697281001943	Recombination protein O C terminal; Region: RecO_C; pfam02565
697281001944	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
697281001945	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
697281001946	active site
697281001947	substrate binding site [chemical binding]; other site
697281001948	metal binding site [ion binding]; metal-binding site
697281001949	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
697281001950	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
697281001951	glutaminase active site [active]
697281001952	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
697281001953	dimer interface [polypeptide binding]; other site
697281001954	active site
697281001955	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
697281001956	dimer interface [polypeptide binding]; other site
697281001957	active site
697281001958	Penicillinase repressor; Region: Pencillinase_R; pfam03965
697281001959	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
697281001960	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281001961	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
697281001962	non-specific DNA binding site [nucleotide binding]; other site
697281001963	salt bridge; other site
697281001964	sequence-specific DNA binding site [nucleotide binding]; other site
697281001965	transposase; Provisional; Region: PRK06526
697281001966	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281001967	Walker A motif; other site
697281001968	ATP binding site [chemical binding]; other site
697281001969	Walker B motif; other site
697281001970	arginine finger; other site
697281001971	AAA domain; Region: AAA_11; pfam13086
697281001972	Part of AAA domain; Region: AAA_19; pfam13245
697281001973	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
697281001974	AAA domain; Region: AAA_30; pfam13604
697281001975	AAA domain; Region: AAA_12; pfam13087
697281001976	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
697281001977	putative active site [active]
697281001978	bacterial Hfq-like; Region: Hfq; cd01716
697281001979	hexamer interface [polypeptide binding]; other site
697281001980	Sm1 motif; other site
697281001981	RNA binding site [nucleotide binding]; other site
697281001982	Sm2 motif; other site
697281001983	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
697281001984	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
697281001985	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
697281001986	Competence protein; Region: Competence; pfam03772
697281001987	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
697281001988	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
697281001989	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
697281001990	hypothetical protein; Provisional; Region: PRK05473
697281001991	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
697281001992	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
697281001993	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
697281001994	G1 box; other site
697281001995	GTP/Mg2+ binding site [chemical binding]; other site
697281001996	Switch I region; other site
697281001997	G2 box; other site
697281001998	G3 box; other site
697281001999	Switch II region; other site
697281002000	G4 box; other site
697281002001	G5 box; other site
697281002002	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
697281002003	Nucleoside recognition; Region: Gate; pfam07670
697281002004	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
697281002005	Nucleoside recognition; Region: Gate; pfam07670
697281002006	FeoA domain; Region: FeoA; pfam04023
697281002007	ferric uptake regulator; Provisional; Region: fur; PRK09462
697281002008	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
697281002009	metal binding site 2 [ion binding]; metal-binding site
697281002010	putative DNA binding helix; other site
697281002011	metal binding site 1 [ion binding]; metal-binding site
697281002012	dimer interface [polypeptide binding]; other site
697281002013	structural Zn2+ binding site [ion binding]; other site
697281002014	antiporter inner membrane protein; Provisional; Region: PRK11670
697281002015	Domain of unknown function DUF59; Region: DUF59; pfam01883
697281002016	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
697281002017	Walker A motif; other site
697281002018	Helix-turn-helix domain; Region: HTH_28; pfam13518
697281002019	Winged helix-turn helix; Region: HTH_29; pfam13551
697281002020	Integrase core domain; Region: rve; pfam00665
697281002021	Integrase core domain; Region: rve_3; cl15866
697281002022	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
697281002023	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
697281002024	active site
697281002025	HIGH motif; other site
697281002026	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
697281002027	active site
697281002028	KMSKS motif; other site
697281002029	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
697281002030	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
697281002031	ABC transporter; Region: ABC_tran_2; pfam12848
697281002032	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
697281002033	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
697281002034	hypothetical protein; Provisional; Region: PRK04435
697281002035	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
697281002036	homoserine dehydrogenase; Provisional; Region: PRK06349
697281002037	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
697281002038	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
697281002039	threonine synthase; Reviewed; Region: PRK06721
697281002040	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
697281002041	homodimer interface [polypeptide binding]; other site
697281002042	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281002043	catalytic residue [active]
697281002044	homoserine kinase; Provisional; Region: PRK01212
697281002045	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
697281002046	aspartate kinase; Reviewed; Region: PRK06635
697281002047	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
697281002048	putative catalytic residues [active]
697281002049	putative nucleotide binding site [chemical binding]; other site
697281002050	putative aspartate binding site [chemical binding]; other site
697281002051	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
697281002052	putative allosteric regulatory site; other site
697281002053	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
697281002054	putative allosteric regulatory residue; other site
697281002055	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
697281002056	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
697281002057	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
697281002058	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
697281002059	active site
697281002060	(T/H)XGH motif; other site
697281002061	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
697281002062	Zn2+ binding site [ion binding]; other site
697281002063	Mg2+ binding site [ion binding]; other site
697281002064	GTP-binding protein LepA; Provisional; Region: PRK05433
697281002065	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
697281002066	G1 box; other site
697281002067	putative GEF interaction site [polypeptide binding]; other site
697281002068	GTP/Mg2+ binding site [chemical binding]; other site
697281002069	Switch I region; other site
697281002070	G2 box; other site
697281002071	G3 box; other site
697281002072	Switch II region; other site
697281002073	G4 box; other site
697281002074	G5 box; other site
697281002075	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
697281002076	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
697281002077	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
697281002078	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
697281002079	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281002080	FeS/SAM binding site; other site
697281002081	HemN C-terminal domain; Region: HemN_C; pfam06969
697281002082	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
697281002083	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
697281002084	GrpE; Region: GrpE; pfam01025
697281002085	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
697281002086	dimer interface [polypeptide binding]; other site
697281002087	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
697281002088	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
697281002089	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
697281002090	nucleotide binding site [chemical binding]; other site
697281002091	NEF interaction site [polypeptide binding]; other site
697281002092	SBD interface [polypeptide binding]; other site
697281002093	Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811
697281002094	chaperone protein DnaJ; Provisional; Region: PRK10767
697281002095	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
697281002096	HSP70 interaction site [polypeptide binding]; other site
697281002097	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
697281002098	substrate binding site [polypeptide binding]; other site
697281002099	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
697281002100	Zn binding sites [ion binding]; other site
697281002101	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
697281002102	dimer interface [polypeptide binding]; other site
697281002103	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
697281002104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
697281002105	S-adenosylmethionine binding site [chemical binding]; other site
697281002106	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
697281002107	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
697281002108	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281002109	FeS/SAM binding site; other site
697281002110	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
697281002111	nucleotide binding site/active site [active]
697281002112	HIT family signature motif; other site
697281002113	catalytic residue [active]
697281002114	Response regulator receiver domain; Region: Response_reg; pfam00072
697281002115	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281002116	active site
697281002117	phosphorylation site [posttranslational modification]
697281002118	intermolecular recognition site; other site
697281002119	dimerization interface [polypeptide binding]; other site
697281002120	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281002121	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281002122	Histidine kinase; Region: His_kinase; pfam06580
697281002123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281002124	ATP binding site [chemical binding]; other site
697281002125	Mg2+ binding site [ion binding]; other site
697281002126	G-X-G motif; other site
697281002127	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281002128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281002129	dimer interface [polypeptide binding]; other site
697281002130	conserved gate region; other site
697281002131	ABC-ATPase subunit interface; other site
697281002132	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281002133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281002134	dimer interface [polypeptide binding]; other site
697281002135	conserved gate region; other site
697281002136	putative PBP binding loops; other site
697281002137	ABC-ATPase subunit interface; other site
697281002138	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281002139	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281002140	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
697281002141	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
697281002142	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
697281002143	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
697281002144	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
697281002145	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281002146	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
697281002147	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
697281002148	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281002149	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281002150	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281002151	dihydrodipicolinate reductase; Provisional; Region: PRK00048
697281002152	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
697281002153	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
697281002154	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
697281002155	putative allosteric regulatory site; other site
697281002156	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
697281002157	putative allosteric regulatory residue; other site
697281002158	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
697281002159	dihydrodipicolinate synthase; Region: dapA; TIGR00674
697281002160	dimer interface [polypeptide binding]; other site
697281002161	active site
697281002162	catalytic residue [active]
697281002163	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
697281002164	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
697281002165	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
697281002166	active site
697281002167	catalytic residues [active]
697281002168	oligoendopeptidase F; Region: pepF; TIGR00181
697281002169	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
697281002170	active site
697281002171	Zn binding site [ion binding]; other site
697281002172	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
697281002173	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
697281002174	ATP cone domain; Region: ATP-cone; pfam03477
697281002175	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
697281002176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281002177	active site
697281002178	phosphorylation site [posttranslational modification]
697281002179	intermolecular recognition site; other site
697281002180	dimerization interface [polypeptide binding]; other site
697281002181	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
697281002182	DNA binding site [nucleotide binding]
697281002183	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
697281002184	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
697281002185	Walker A/P-loop; other site
697281002186	ATP binding site [chemical binding]; other site
697281002187	Q-loop/lid; other site
697281002188	ABC transporter signature motif; other site
697281002189	Walker B; other site
697281002190	D-loop; other site
697281002191	H-loop/switch region; other site
697281002192	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
697281002193	PhoU domain; Region: PhoU; pfam01895
697281002194	PhoU domain; Region: PhoU; pfam01895
697281002195	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
697281002196	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
697281002197	putative trimer interface [polypeptide binding]; other site
697281002198	putative CoA binding site [chemical binding]; other site
697281002199	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
697281002200	AIR carboxylase; Region: AIRC; smart01001
697281002201	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
697281002202	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
697281002203	Ligand Binding Site [chemical binding]; other site
697281002204	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
697281002205	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
697281002206	active site
697281002207	catalytic tetrad [active]
697281002208	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281002209	dimerization interface [polypeptide binding]; other site
697281002210	putative DNA binding site [nucleotide binding]; other site
697281002211	putative Zn2+ binding site [ion binding]; other site
697281002212	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
697281002213	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
697281002214	putative binding site residues; other site
697281002215	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
697281002216	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
697281002217	ABC-ATPase subunit  interface; other site
697281002218	dimer interface [polypeptide binding]; other site
697281002219	putative PBP binding regions; other site
697281002220	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
697281002221	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
697281002222	Walker A/P-loop; other site
697281002223	ATP binding site [chemical binding]; other site
697281002224	Q-loop/lid; other site
697281002225	ABC transporter signature motif; other site
697281002226	Walker B; other site
697281002227	D-loop; other site
697281002228	H-loop/switch region; other site
697281002229	cobyric acid synthase; Provisional; Region: PRK00784
697281002230	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
697281002231	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
697281002232	catalytic triad [active]
697281002233	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
697281002234	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
697281002235	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
697281002236	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281002237	homodimer interface [polypeptide binding]; other site
697281002238	catalytic residue [active]
697281002239	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
697281002240	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
697281002241	UbiA prenyltransferase family; Region: UbiA; pfam01040
697281002242	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
697281002243	Dehydroquinase class II; Region: DHquinase_II; pfam01220
697281002244	active site
697281002245	trimer interface [polypeptide binding]; other site
697281002246	dimer interface [polypeptide binding]; other site
697281002247	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
697281002248	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
697281002249	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
697281002250	active site
697281002251	elongation factor P; Validated; Region: PRK00529
697281002252	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
697281002253	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
697281002254	RNA binding site [nucleotide binding]; other site
697281002255	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
697281002256	RNA binding site [nucleotide binding]; other site
697281002257	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
697281002258	non-specific DNA interactions [nucleotide binding]; other site
697281002259	DNA binding site [nucleotide binding]
697281002260	sequence specific DNA binding site [nucleotide binding]; other site
697281002261	putative cAMP binding site [chemical binding]; other site
697281002262	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
697281002263	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
697281002264	nucleotide binding site [chemical binding]; other site
697281002265	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281002266	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281002267	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
697281002268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281002269	dimer interface [polypeptide binding]; other site
697281002270	conserved gate region; other site
697281002271	putative PBP binding loops; other site
697281002272	ABC-ATPase subunit interface; other site
697281002273	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
697281002274	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
697281002275	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281002276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281002277	dimer interface [polypeptide binding]; other site
697281002278	conserved gate region; other site
697281002279	putative PBP binding loops; other site
697281002280	ABC-ATPase subunit interface; other site
697281002281	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
697281002282	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
697281002283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281002284	Walker A motif; other site
697281002285	ATP binding site [chemical binding]; other site
697281002286	Walker B motif; other site
697281002287	arginine finger; other site
697281002288	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548
697281002289	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
697281002290	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
697281002291	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546
697281002292	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
697281002293	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
697281002294	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
697281002295	Asp23 family; Region: Asp23; pfam03780
697281002296	Asp23 family; Region: Asp23; pfam03780
697281002297	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
697281002298	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
697281002299	putative RNA binding site [nucleotide binding]; other site
697281002300	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
697281002301	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
697281002302	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
697281002303	homodimer interface [polypeptide binding]; other site
697281002304	NADP binding site [chemical binding]; other site
697281002305	substrate binding site [chemical binding]; other site
697281002306	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
697281002307	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
697281002308	generic binding surface II; other site
697281002309	generic binding surface I; other site
697281002310	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
697281002311	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
697281002312	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
697281002313	substrate binding pocket [chemical binding]; other site
697281002314	chain length determination region; other site
697281002315	substrate-Mg2+ binding site; other site
697281002316	catalytic residues [active]
697281002317	aspartate-rich region 1; other site
697281002318	active site lid residues [active]
697281002319	aspartate-rich region 2; other site
697281002320	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
697281002321	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
697281002322	TPP-binding site; other site
697281002323	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
697281002324	PYR/PP interface [polypeptide binding]; other site
697281002325	dimer interface [polypeptide binding]; other site
697281002326	TPP binding site [chemical binding]; other site
697281002327	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
697281002328	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
697281002329	ATP-NAD kinase; Region: NAD_kinase; pfam01513
697281002330	arginine repressor; Provisional; Region: argR; PRK00441
697281002331	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
697281002332	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
697281002333	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
697281002334	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
697281002335	Walker A/P-loop; other site
697281002336	ATP binding site [chemical binding]; other site
697281002337	Q-loop/lid; other site
697281002338	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
697281002339	ABC transporter signature motif; other site
697281002340	Walker B; other site
697281002341	D-loop; other site
697281002342	H-loop/switch region; other site
697281002343	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
697281002344	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
697281002345	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
697281002346	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
697281002347	putative active site [active]
697281002348	catalytic residue [active]
697281002349	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
697281002350	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
697281002351	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
697281002352	ATP binding site [chemical binding]; other site
697281002353	putative Mg++ binding site [ion binding]; other site
697281002354	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
697281002355	nucleotide binding region [chemical binding]; other site
697281002356	ATP-binding site [chemical binding]; other site
697281002357	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
697281002358	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
697281002359	SurA N-terminal domain; Region: SurA_N_3; cl07813
697281002360	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
697281002361	stage V sporulation protein T; Region: spore_V_T; TIGR02851
697281002362	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
697281002363	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
697281002364	stage V sporulation protein B; Region: spore_V_B; TIGR02900
697281002365	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
697281002366	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
697281002367	homodimer interface [polypeptide binding]; other site
697281002368	metal binding site [ion binding]; metal-binding site
697281002369	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
697281002370	homodimer interface [polypeptide binding]; other site
697281002371	active site
697281002372	putative chemical substrate binding site [chemical binding]; other site
697281002373	metal binding site [ion binding]; metal-binding site
697281002374	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
697281002375	IHF dimer interface [polypeptide binding]; other site
697281002376	IHF - DNA interface [nucleotide binding]; other site
697281002377	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
697281002378	RNA binding surface [nucleotide binding]; other site
697281002379	Stage II sporulation protein; Region: SpoIID; pfam08486
697281002380	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
697281002381	YabP family; Region: YabP; cl06766
697281002382	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801
697281002383	Septum formation initiator; Region: DivIC; pfam04977
697281002384	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
697281002385	hypothetical protein; Provisional; Region: PRK08582
697281002386	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
697281002387	RNA binding site [nucleotide binding]; other site
697281002388	competence damage-inducible protein A; Provisional; Region: PRK00549
697281002389	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
697281002390	putative MPT binding site; other site
697281002391	Y-family of DNA polymerases; Region: PolY; cl12025
697281002392	Competence-damaged protein; Region: CinA; pfam02464
697281002393	recombinase A; Provisional; Region: recA; PRK09354
697281002394	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
697281002395	hexamer interface [polypeptide binding]; other site
697281002396	Walker A motif; other site
697281002397	ATP binding site [chemical binding]; other site
697281002398	Walker B motif; other site
697281002399	recombination regulator RecX; Reviewed; Region: recX; PRK00117
697281002400	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
697281002401	active site
697281002402	metal binding site [ion binding]; metal-binding site
697281002403	DNA binding site [nucleotide binding]
697281002404	chromosome segregation protein; Provisional; Region: PRK01156
697281002405	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281002406	Walker A/P-loop; other site
697281002407	ATP binding site [chemical binding]; other site
697281002408	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
697281002409	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
697281002410	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281002411	Q-loop/lid; other site
697281002412	ABC transporter signature motif; other site
697281002413	Walker B; other site
697281002414	D-loop; other site
697281002415	H-loop/switch region; other site
697281002416	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
697281002417	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
697281002418	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
697281002419	aldehyde dehydrogenase EutE; Provisional; Region: PRK15398
697281002420	NAD(P) binding site [chemical binding]; other site
697281002421	catalytic residues [active]
697281002422	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
697281002423	propionate/acetate kinase; Provisional; Region: PRK12379
697281002424	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
697281002425	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
697281002426	Hexamer interface [polypeptide binding]; other site
697281002427	Hexagonal pore residue; other site
697281002428	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
697281002429	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
697281002430	Hexamer interface [polypeptide binding]; other site
697281002431	Hexagonal pore residue; other site
697281002432	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
697281002433	intersubunit interface [polypeptide binding]; other site
697281002434	active site
697281002435	zinc binding site [ion binding]; other site
697281002436	Na+ binding site [ion binding]; other site
697281002437	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
697281002438	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
697281002439	Hexamer interface [polypeptide binding]; other site
697281002440	Hexagonal pore residue; other site
697281002441	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
697281002442	Propanediol utilisation protein PduL; Region: PduL; pfam06130
697281002443	Propanediol utilisation protein PduL; Region: PduL; pfam06130
697281002444	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
697281002445	Hexamer/Pentamer interface [polypeptide binding]; other site
697281002446	central pore; other site
697281002447	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
697281002448	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
697281002449	Hexamer interface [polypeptide binding]; other site
697281002450	Hexagonal pore residue; other site
697281002451	aldehyde dehydrogenase EutE; Provisional; Region: PRK15398
697281002452	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
697281002453	NAD(P) binding site [chemical binding]; other site
697281002454	catalytic residues [active]
697281002455	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
697281002456	SLBB domain; Region: SLBB; pfam10531
697281002457	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
697281002458	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
697281002459	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
697281002460	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
697281002461	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
697281002462	putative hexamer interface [polypeptide binding]; other site
697281002463	putative hexagonal pore; other site
697281002464	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
697281002465	putative hexamer interface [polypeptide binding]; other site
697281002466	putative hexagonal pore; other site
697281002467	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
697281002468	propionate/acetate kinase; Provisional; Region: PRK12379
697281002469	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
697281002470	Ligand binding site [chemical binding]; other site
697281002471	Electron transfer flavoprotein domain; Region: ETF; pfam01012
697281002472	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
697281002473	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
697281002474	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
697281002475	FAD binding domain; Region: FAD_binding_4; pfam01565
697281002476	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
697281002477	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
697281002478	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
697281002479	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
697281002480	PhoU domain; Region: PhoU; pfam01895
697281002481	PhoU domain; Region: PhoU; pfam01895
697281002482	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
697281002483	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
697281002484	nucleotide binding site [chemical binding]; other site
697281002485	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
697281002486	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
697281002487	Domain of unknown function DUF20; Region: UPF0118; pfam01594
697281002488	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
697281002489	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281002490	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281002491	DNA binding residues [nucleotide binding]
697281002492	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
697281002493	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
697281002494	DNA protecting protein DprA; Region: dprA; TIGR00732
697281002495	DNA topoisomerase I; Validated; Region: PRK05582
697281002496	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
697281002497	active site
697281002498	interdomain interaction site; other site
697281002499	putative metal-binding site [ion binding]; other site
697281002500	nucleotide binding site [chemical binding]; other site
697281002501	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
697281002502	domain I; other site
697281002503	DNA binding groove [nucleotide binding]
697281002504	phosphate binding site [ion binding]; other site
697281002505	domain II; other site
697281002506	domain III; other site
697281002507	nucleotide binding site [chemical binding]; other site
697281002508	catalytic site [active]
697281002509	domain IV; other site
697281002510	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
697281002511	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
697281002512	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
697281002513	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
697281002514	Glucose inhibited division protein A; Region: GIDA; pfam01134
697281002515	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
697281002516	active site
697281002517	HslU subunit interaction site [polypeptide binding]; other site
697281002518	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
697281002519	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281002520	Walker A motif; other site
697281002521	ATP binding site [chemical binding]; other site
697281002522	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
697281002523	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
697281002524	transcriptional repressor CodY; Validated; Region: PRK04158
697281002525	CodY GAF-like domain; Region: CodY; pfam06018
697281002526	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
697281002527	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
697281002528	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
697281002529	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
697281002530	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
697281002531	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
697281002532	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
697281002533	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
697281002534	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
697281002535	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
697281002536	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
697281002537	FliG C-terminal domain; Region: FliG_C; pfam01706
697281002538	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
697281002539	Flagellar assembly protein FliH; Region: FliH; pfam02108
697281002540	Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157
697281002541	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
697281002542	Walker A motif/ATP binding site; other site
697281002543	Walker B motif; other site
697281002544	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
697281002545	Uncharacterized conserved protein [Function unknown]; Region: COG3334
697281002546	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
697281002547	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
697281002548	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
697281002549	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
697281002550	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
697281002551	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
697281002552	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
697281002553	Flagellar protein (FlbD); Region: FlbD; pfam06289
697281002554	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
697281002555	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
697281002556	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
697281002557	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
697281002558	ligand binding site [chemical binding]; other site
697281002559	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
697281002560	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
697281002561	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
697281002562	flagellar motor switch protein; Validated; Region: PRK08119
697281002563	CheC-like family; Region: CheC; pfam04509
697281002564	CheC-like family; Region: CheC; pfam04509
697281002565	flagellar motor switch protein FliN; Region: fliN; TIGR02480
697281002566	Response regulator receiver domain; Region: Response_reg; pfam00072
697281002567	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281002568	active site
697281002569	phosphorylation site [posttranslational modification]
697281002570	intermolecular recognition site; other site
697281002571	dimerization interface [polypeptide binding]; other site
697281002572	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
697281002573	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
697281002574	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
697281002575	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
697281002576	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
697281002577	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
697281002578	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
697281002579	FHIPEP family; Region: FHIPEP; pfam00771
697281002580	Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419
697281002581	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281002582	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
697281002583	Walker A/P-loop; other site
697281002584	ATP binding site [chemical binding]; other site
697281002585	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
697281002586	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
697281002587	P-loop; other site
697281002588	Flagellar protein YcgR; Region: YcgR_2; pfam12945
697281002589	PilZ domain; Region: PilZ; pfam07238
697281002590	CheB methylesterase; Region: CheB_methylest; pfam01339
697281002591	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
697281002592	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
697281002593	putative binding surface; other site
697281002594	active site
697281002595	P2 response regulator binding domain; Region: P2; pfam07194
697281002596	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
697281002597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281002598	ATP binding site [chemical binding]; other site
697281002599	Mg2+ binding site [ion binding]; other site
697281002600	G-X-G motif; other site
697281002601	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
697281002602	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
697281002603	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
697281002604	CheC-like family; Region: CheC; pfam04509
697281002605	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488
697281002606	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
697281002607	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281002608	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281002609	DNA binding residues [nucleotide binding]
697281002610	Protein of unknown function (DUF342); Region: DUF342; pfam03961
697281002611	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
697281002612	YceG-like family; Region: YceG; pfam02618
697281002613	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
697281002614	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
697281002615	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
697281002616	Potassium binding sites [ion binding]; other site
697281002617	Cesium cation binding sites [ion binding]; other site
697281002618	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
697281002619	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
697281002620	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
697281002621	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
697281002622	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
697281002623	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
697281002624	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
697281002625	FAD binding site [chemical binding]; other site
697281002626	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
697281002627	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
697281002628	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
697281002629	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
697281002630	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
697281002631	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
697281002632	4Fe-4S binding domain; Region: Fer4; pfam00037
697281002633	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
697281002634	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
697281002635	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
697281002636	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
697281002637	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
697281002638	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
697281002639	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
697281002640	FAD binding pocket [chemical binding]; other site
697281002641	FAD binding motif [chemical binding]; other site
697281002642	phosphate binding motif [ion binding]; other site
697281002643	beta-alpha-beta structure motif; other site
697281002644	NAD binding pocket [chemical binding]; other site
697281002645	Iron coordination center [ion binding]; other site
697281002646	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
697281002647	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
697281002648	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
697281002649	catalytic residue [active]
697281002650	Transcriptional regulators [Transcription]; Region: MarR; COG1846
697281002651	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
697281002652	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
697281002653	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
697281002654	nucleotide binding site [chemical binding]; other site
697281002655	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
697281002656	Chromate transporter; Region: Chromate_transp; pfam02417
697281002657	Chromate transporter; Region: Chromate_transp; pfam02417
697281002658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281002659	ATP binding site [chemical binding]; other site
697281002660	Mg2+ binding site [ion binding]; other site
697281002661	G-X-G motif; other site
697281002662	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
697281002663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281002664	active site
697281002665	phosphorylation site [posttranslational modification]
697281002666	intermolecular recognition site; other site
697281002667	dimerization interface [polypeptide binding]; other site
697281002668	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
697281002669	DNA binding site [nucleotide binding]
697281002670	sensory histidine kinase CreC; Provisional; Region: PRK11100
697281002671	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281002672	dimerization interface [polypeptide binding]; other site
697281002673	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
697281002674	dimer interface [polypeptide binding]; other site
697281002675	phosphorylation site [posttranslational modification]
697281002676	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281002677	ATP binding site [chemical binding]; other site
697281002678	Mg2+ binding site [ion binding]; other site
697281002679	G-X-G motif; other site
697281002680	Sporulation and spore germination; Region: Germane; pfam10646
697281002681	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
697281002682	Sporulation and spore germination; Region: Germane; pfam10646
697281002683	Sporulation and spore germination; Region: Germane; smart00909
697281002684	Sporulation and spore germination; Region: Germane; pfam10646
697281002685	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
697281002686	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
697281002687	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
697281002688	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
697281002689	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
697281002690	GatB domain; Region: GatB_Yqey; smart00845
697281002691	Sporulation and spore germination; Region: Germane; pfam10646
697281002692	Sporulation and spore germination; Region: Germane; pfam10646
697281002693	ribonuclease PH; Reviewed; Region: rph; PRK00173
697281002694	Ribonuclease PH; Region: RNase_PH_bact; cd11362
697281002695	hexamer interface [polypeptide binding]; other site
697281002696	active site
697281002697	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
697281002698	active site
697281002699	dimerization interface [polypeptide binding]; other site
697281002700	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
697281002701	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
697281002702	active site
697281002703	metal binding site [ion binding]; metal-binding site
697281002704	homotetramer interface [polypeptide binding]; other site
697281002705	trigger factor; Provisional; Region: tig; PRK01490
697281002706	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
697281002707	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
697281002708	Clp protease; Region: CLP_protease; pfam00574
697281002709	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
697281002710	oligomer interface [polypeptide binding]; other site
697281002711	active site residues [active]
697281002712	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
697281002713	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
697281002714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281002715	Walker A motif; other site
697281002716	ATP binding site [chemical binding]; other site
697281002717	Walker B motif; other site
697281002718	arginine finger; other site
697281002719	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
697281002720	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
697281002721	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281002722	Walker A motif; other site
697281002723	ATP binding site [chemical binding]; other site
697281002724	Walker B motif; other site
697281002725	arginine finger; other site
697281002726	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
697281002727	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
697281002728	G1 box; other site
697281002729	GTP/Mg2+ binding site [chemical binding]; other site
697281002730	Switch I region; other site
697281002731	G2 box; other site
697281002732	G3 box; other site
697281002733	Switch II region; other site
697281002734	G4 box; other site
697281002735	G5 box; other site
697281002736	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
697281002737	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
697281002738	Preprotein translocase subunit; Region: YajC; pfam02699
697281002739	Protein of unknown function (DUF3792); Region: DUF3792; pfam12670
697281002740	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
697281002741	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
697281002742	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281002743	FeS/SAM binding site; other site
697281002744	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
697281002745	protein-export membrane protein SecD; Region: secD; TIGR01129
697281002746	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
697281002747	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
697281002748	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
697281002749	Protein export membrane protein; Region: SecD_SecF; pfam02355
697281002750	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
697281002751	DHH family; Region: DHH; pfam01368
697281002752	DHHA1 domain; Region: DHHA1; pfam02272
697281002753	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
697281002754	active site
697281002755	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
697281002756	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
697281002757	Zn2+ binding site [ion binding]; other site
697281002758	Mg2+ binding site [ion binding]; other site
697281002759	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
697281002760	synthetase active site [active]
697281002761	NTP binding site [chemical binding]; other site
697281002762	metal binding site [ion binding]; metal-binding site
697281002763	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
697281002764	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
697281002765	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
697281002766	Homeodomain-like domain; Region: HTH_23; cl17451
697281002767	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
697281002768	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
697281002769	dimer interface [polypeptide binding]; other site
697281002770	motif 1; other site
697281002771	active site
697281002772	motif 2; other site
697281002773	motif 3; other site
697281002774	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
697281002775	anticodon binding site; other site
697281002776	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
697281002777	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
697281002778	dimer interface [polypeptide binding]; other site
697281002779	anticodon binding site; other site
697281002780	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
697281002781	homodimer interface [polypeptide binding]; other site
697281002782	motif 1; other site
697281002783	active site
697281002784	motif 2; other site
697281002785	GAD domain; Region: GAD; pfam02938
697281002786	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
697281002787	motif 3; other site
697281002788	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
697281002789	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
697281002790	putative ATP binding site [chemical binding]; other site
697281002791	putative substrate interface [chemical binding]; other site
697281002792	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
697281002793	putative homodimer interface [polypeptide binding]; other site
697281002794	putative homotetramer interface [polypeptide binding]; other site
697281002795	putative allosteric switch controlling residues; other site
697281002796	putative metal binding site [ion binding]; other site
697281002797	putative homodimer-homodimer interface [polypeptide binding]; other site
697281002798	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
697281002799	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
697281002800	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
697281002801	catalytic residues [active]
697281002802	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
697281002803	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
697281002804	dimer interface [polypeptide binding]; other site
697281002805	active site
697281002806	glycine-pyridoxal phosphate binding site [chemical binding]; other site
697281002807	folate binding site [chemical binding]; other site
697281002808	recombination factor protein RarA; Reviewed; Region: PRK13342
697281002809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281002810	Walker A motif; other site
697281002811	ATP binding site [chemical binding]; other site
697281002812	Walker B motif; other site
697281002813	arginine finger; other site
697281002814	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
697281002815	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
697281002816	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
697281002817	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
697281002818	Clp protease; Region: CLP_protease; pfam00574
697281002819	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
697281002820	active site
697281002821	YlzJ-like protein; Region: YlzJ; pfam14035
697281002822	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
697281002823	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
697281002824	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
697281002825	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
697281002826	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
697281002827	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
697281002828	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281002829	FeS/SAM binding site; other site
697281002830	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
697281002831	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
697281002832	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
697281002833	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
697281002834	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
697281002835	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
697281002836	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
697281002837	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
697281002838	putative active site [active]
697281002839	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
697281002840	catalytic core [active]
697281002841	flavoprotein, HI0933 family; Region: TIGR00275
697281002842	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
697281002843	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
697281002844	active site
697281002845	dimer interface [polypeptide binding]; other site
697281002846	effector binding site; other site
697281002847	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
697281002848	protein-splicing catalytic site; other site
697281002849	thioester formation/cholesterol transfer; other site
697281002850	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
697281002851	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942
697281002852	Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867
697281002853	TSCPD domain; Region: TSCPD; pfam12637
697281002854	hypothetical protein; Validated; Region: PRK00110
697281002855	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
697281002856	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
697281002857	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
697281002858	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
697281002859	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
697281002860	RNA binding surface [nucleotide binding]; other site
697281002861	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
697281002862	active site
697281002863	spermidine synthase; Provisional; Region: PRK00811
697281002864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
697281002865	S-adenosylmethionine binding site [chemical binding]; other site
697281002866	agmatinase; Region: agmatinase; TIGR01230
697281002867	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
697281002868	putative active site [active]
697281002869	Mn binding site [ion binding]; other site
697281002870	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
697281002871	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
697281002872	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
697281002873	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
697281002874	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
697281002875	carboxyltransferase (CT) interaction site; other site
697281002876	biotinylation site [posttranslational modification]; other site
697281002877	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
697281002878	oxaloacetate decarboxylase; Provisional; Region: PRK12331
697281002879	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
697281002880	active site
697281002881	catalytic residues [active]
697281002882	metal binding site [ion binding]; metal-binding site
697281002883	homodimer binding site [polypeptide binding]; other site
697281002884	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
697281002885	regulatory protein interface [polypeptide binding]; other site
697281002886	regulatory phosphorylation site [posttranslational modification]; other site
697281002887	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281002888	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
697281002889	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
697281002890	Walker A/P-loop; other site
697281002891	ATP binding site [chemical binding]; other site
697281002892	Q-loop/lid; other site
697281002893	ABC transporter signature motif; other site
697281002894	Walker B; other site
697281002895	D-loop; other site
697281002896	H-loop/switch region; other site
697281002897	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281002898	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
697281002899	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281002900	Walker A/P-loop; other site
697281002901	ATP binding site [chemical binding]; other site
697281002902	Q-loop/lid; other site
697281002903	ABC transporter signature motif; other site
697281002904	Walker B; other site
697281002905	D-loop; other site
697281002906	H-loop/switch region; other site
697281002907	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
697281002908	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281002909	dimerization interface [polypeptide binding]; other site
697281002910	putative Zn2+ binding site [ion binding]; other site
697281002911	putative DNA binding site [nucleotide binding]; other site
697281002912	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
697281002913	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
697281002914	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
697281002915	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
697281002916	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
697281002917	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
697281002918	Domain of unknown function (DUF814); Region: DUF814; pfam05670
697281002919	hypothetical protein; Provisional; Region: PRK11820
697281002920	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
697281002921	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
697281002922	hypothetical protein; Provisional; Region: PRK04323
697281002923	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
697281002924	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
697281002925	catalytic site [active]
697281002926	G-X2-G-X-G-K; other site
697281002927	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
697281002928	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
697281002929	Flavoprotein; Region: Flavoprotein; pfam02441
697281002930	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
697281002931	primosome assembly protein PriA; Validated; Region: PRK05580
697281002932	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
697281002933	ATP binding site [chemical binding]; other site
697281002934	putative Mg++ binding site [ion binding]; other site
697281002935	helicase superfamily c-terminal domain; Region: HELICc; smart00490
697281002936	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
697281002937	active site
697281002938	catalytic residues [active]
697281002939	metal binding site [ion binding]; metal-binding site
697281002940	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
697281002941	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
697281002942	putative active site [active]
697281002943	substrate binding site [chemical binding]; other site
697281002944	putative cosubstrate binding site; other site
697281002945	catalytic site [active]
697281002946	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
697281002947	substrate binding site [chemical binding]; other site
697281002948	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
697281002949	16S rRNA methyltransferase B; Provisional; Region: PRK14902
697281002950	NusB family; Region: NusB; pfam01029
697281002951	putative RNA binding site [nucleotide binding]; other site
697281002952	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
697281002953	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
697281002954	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281002955	FeS/SAM binding site; other site
697281002956	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
697281002957	Protein phosphatase 2C; Region: PP2C; pfam00481
697281002958	active site
697281002959	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
697281002960	Catalytic domain of Protein Kinases; Region: PKc; cd00180
697281002961	active site
697281002962	ATP binding site [chemical binding]; other site
697281002963	substrate binding site [chemical binding]; other site
697281002964	activation loop (A-loop); other site
697281002965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
697281002966	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
697281002967	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
697281002968	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
697281002969	GTPase RsgA; Reviewed; Region: PRK00098
697281002970	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
697281002971	RNA binding site [nucleotide binding]; other site
697281002972	homodimer interface [polypeptide binding]; other site
697281002973	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
697281002974	GTPase/Zn-binding domain interface [polypeptide binding]; other site
697281002975	GTP/Mg2+ binding site [chemical binding]; other site
697281002976	G4 box; other site
697281002977	G5 box; other site
697281002978	G1 box; other site
697281002979	Switch I region; other site
697281002980	G2 box; other site
697281002981	G3 box; other site
697281002982	Switch II region; other site
697281002983	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
697281002984	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
697281002985	substrate binding site [chemical binding]; other site
697281002986	hexamer interface [polypeptide binding]; other site
697281002987	metal binding site [ion binding]; metal-binding site
697281002988	Thiamine pyrophosphokinase; Region: TPK; cd07995
697281002989	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
697281002990	active site
697281002991	dimerization interface [polypeptide binding]; other site
697281002992	thiamine binding site [chemical binding]; other site
697281002993	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
697281002994	Asp23 family; Region: Asp23; pfam03780
697281002995	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
697281002996	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
697281002997	ssDNA binding site; other site
697281002998	generic binding surface II; other site
697281002999	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
697281003000	ATP binding site [chemical binding]; other site
697281003001	putative Mg++ binding site [ion binding]; other site
697281003002	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
697281003003	nucleotide binding region [chemical binding]; other site
697281003004	ATP-binding site [chemical binding]; other site
697281003005	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
697281003006	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
697281003007	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
697281003008	S-adenosylmethionine binding site [chemical binding]; other site
697281003009	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
697281003010	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
697281003011	active site
697281003012	(T/H)XGH motif; other site
697281003013	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
697281003014	Nucleoside recognition; Region: Gate; pfam07670
697281003015	hypothetical protein; Provisional; Region: PRK13670
697281003016	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
697281003017	MoxR-like ATPases [General function prediction only]; Region: COG0714
697281003018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281003019	Walker A motif; other site
697281003020	ATP binding site [chemical binding]; other site
697281003021	Walker B motif; other site
697281003022	arginine finger; other site
697281003023	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
697281003024	Protein of unknown function DUF58; Region: DUF58; pfam01882
697281003025	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
697281003026	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
697281003027	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
697281003028	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
697281003029	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
697281003030	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
697281003031	NlpC/P60 family; Region: NLPC_P60; cl17555
697281003032	pur operon repressor; Provisional; Region: PRK09213
697281003033	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
697281003034	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
697281003035	active site
697281003036	regulatory protein SpoVG; Reviewed; Region: PRK13259
697281003037	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
697281003038	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
697281003039	Substrate binding site; other site
697281003040	Mg++ binding site; other site
697281003041	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
697281003042	active site
697281003043	substrate binding site [chemical binding]; other site
697281003044	CoA binding site [chemical binding]; other site
697281003045	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
697281003046	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
697281003047	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
697281003048	active site
697281003049	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
697281003050	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
697281003051	Carbohydrate binding domain; Region: CBM_25; smart01066
697281003052	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
697281003053	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
697281003054	active site
697281003055	dimer interfaces [polypeptide binding]; other site
697281003056	catalytic residues [active]
697281003057	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
697281003058	Peptidase family M23; Region: Peptidase_M23; pfam01551
697281003059	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
697281003060	Peptidase family M50; Region: Peptidase_M50; pfam02163
697281003061	active site
697281003062	putative substrate binding region [chemical binding]; other site
697281003063	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
697281003064	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
697281003065	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
697281003066	B12 binding site [chemical binding]; other site
697281003067	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281003068	FeS/SAM binding site; other site
697281003069	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
697281003070	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
697281003071	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
697281003072	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
697281003073	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
697281003074	putative active site [active]
697281003075	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
697281003076	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
697281003077	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
697281003078	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
697281003079	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
697281003080	NAD synthetase; Provisional; Region: PRK13980
697281003081	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
697281003082	homodimer interface [polypeptide binding]; other site
697281003083	NAD binding pocket [chemical binding]; other site
697281003084	ATP binding pocket [chemical binding]; other site
697281003085	Mg binding site [ion binding]; other site
697281003086	active-site loop [active]
697281003087	Transcriptional regulator [Transcription]; Region: LytR; COG1316
697281003088	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
697281003089	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
697281003090	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
697281003091	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
697281003092	RNA binding surface [nucleotide binding]; other site
697281003093	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
697281003094	active site
697281003095	ribosome maturation protein RimP; Reviewed; Region: PRK00092
697281003096	hypothetical protein; Provisional; Region: PRK14641
697281003097	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
697281003098	putative oligomer interface [polypeptide binding]; other site
697281003099	putative RNA binding site [nucleotide binding]; other site
697281003100	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
697281003101	NusA N-terminal domain; Region: NusA_N; pfam08529
697281003102	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
697281003103	RNA binding site [nucleotide binding]; other site
697281003104	homodimer interface [polypeptide binding]; other site
697281003105	NusA-like KH domain; Region: KH_5; pfam13184
697281003106	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
697281003107	G-X-X-G motif; other site
697281003108	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
697281003109	putative RNA binding cleft [nucleotide binding]; other site
697281003110	translation initiation factor IF-2; Validated; Region: infB; PRK05306
697281003111	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
697281003112	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
697281003113	G1 box; other site
697281003114	putative GEF interaction site [polypeptide binding]; other site
697281003115	GTP/Mg2+ binding site [chemical binding]; other site
697281003116	Switch I region; other site
697281003117	G2 box; other site
697281003118	G3 box; other site
697281003119	Switch II region; other site
697281003120	G4 box; other site
697281003121	G5 box; other site
697281003122	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
697281003123	Translation-initiation factor 2; Region: IF-2; pfam11987
697281003124	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
697281003125	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
697281003126	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
697281003127	DHH family; Region: DHH; pfam01368
697281003128	DHHA1 domain; Region: DHHA1; pfam02272
697281003129	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
697281003130	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
697281003131	RNA binding site [nucleotide binding]; other site
697281003132	active site
697281003133	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
697281003134	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
697281003135	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
697281003136	active site
697281003137	Riboflavin kinase; Region: Flavokinase; pfam01687
697281003138	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
697281003139	16S/18S rRNA binding site [nucleotide binding]; other site
697281003140	S13e-L30e interaction site [polypeptide binding]; other site
697281003141	25S rRNA binding site [nucleotide binding]; other site
697281003142	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
697281003143	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
697281003144	RNase E interface [polypeptide binding]; other site
697281003145	trimer interface [polypeptide binding]; other site
697281003146	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
697281003147	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
697281003148	RNase E interface [polypeptide binding]; other site
697281003149	trimer interface [polypeptide binding]; other site
697281003150	active site
697281003151	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
697281003152	putative nucleic acid binding region [nucleotide binding]; other site
697281003153	G-X-X-G motif; other site
697281003154	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
697281003155	RNA binding site [nucleotide binding]; other site
697281003156	domain interface; other site
697281003157	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
697281003158	NodB motif; other site
697281003159	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
697281003160	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
697281003161	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
697281003162	active site 2 [active]
697281003163	active site 1 [active]
697281003164	putative phosphate acyltransferase; Provisional; Region: PRK05331
697281003165	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
697281003166	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
697281003167	dimer interface [polypeptide binding]; other site
697281003168	active site
697281003169	CoA binding pocket [chemical binding]; other site
697281003170	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
697281003171	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
697281003172	FMN binding site [chemical binding]; other site
697281003173	substrate binding site [chemical binding]; other site
697281003174	putative catalytic residue [active]
697281003175	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
697281003176	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
697281003177	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
697281003178	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
697281003179	NAD(P) binding site [chemical binding]; other site
697281003180	homotetramer interface [polypeptide binding]; other site
697281003181	homodimer interface [polypeptide binding]; other site
697281003182	active site
697281003183	acyl carrier protein; Provisional; Region: acpP; PRK00982
697281003184	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
697281003185	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
697281003186	dimer interface [polypeptide binding]; other site
697281003187	active site
697281003188	ribonuclease III; Reviewed; Region: rnc; PRK00102
697281003189	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
697281003190	dimerization interface [polypeptide binding]; other site
697281003191	active site
697281003192	metal binding site [ion binding]; metal-binding site
697281003193	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
697281003194	dsRNA binding site [nucleotide binding]; other site
697281003195	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281003196	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
697281003197	FeS/SAM binding site; other site
697281003198	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
697281003199	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
697281003200	Walker A/P-loop; other site
697281003201	ATP binding site [chemical binding]; other site
697281003202	Q-loop/lid; other site
697281003203	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
697281003204	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
697281003205	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
697281003206	Q-loop/lid; other site
697281003207	ABC transporter signature motif; other site
697281003208	Walker B; other site
697281003209	D-loop; other site
697281003210	H-loop/switch region; other site
697281003211	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
697281003212	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
697281003213	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
697281003214	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281003215	DNA binding residues [nucleotide binding]
697281003216	signal recognition particle protein; Provisional; Region: PRK10867
697281003217	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
697281003218	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
697281003219	P loop; other site
697281003220	GTP binding site [chemical binding]; other site
697281003221	Signal peptide binding domain; Region: SRP_SPB; pfam02978
697281003222	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
697281003223	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
697281003224	hypothetical protein; Provisional; Region: PRK00468
697281003225	G-X-X-G motif; other site
697281003226	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
697281003227	RimM N-terminal domain; Region: RimM; pfam01782
697281003228	PRC-barrel domain; Region: PRC; pfam05239
697281003229	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
697281003230	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
697281003231	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
697281003232	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
697281003233	Catalytic site [active]
697281003234	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
697281003235	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
697281003236	GTP/Mg2+ binding site [chemical binding]; other site
697281003237	G4 box; other site
697281003238	G5 box; other site
697281003239	G1 box; other site
697281003240	Switch I region; other site
697281003241	G2 box; other site
697281003242	G3 box; other site
697281003243	Switch II region; other site
697281003244	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
697281003245	RNA/DNA hybrid binding site [nucleotide binding]; other site
697281003246	active site
697281003247	hypothetical protein; Reviewed; Region: PRK12497
697281003248	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
697281003249	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
697281003250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281003251	Walker A motif; other site
697281003252	ATP binding site [chemical binding]; other site
697281003253	Walker B motif; other site
697281003254	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
697281003255	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281003256	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281003257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003258	dimer interface [polypeptide binding]; other site
697281003259	conserved gate region; other site
697281003260	putative PBP binding loops; other site
697281003261	ABC-ATPase subunit interface; other site
697281003262	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281003263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003264	dimer interface [polypeptide binding]; other site
697281003265	conserved gate region; other site
697281003266	putative PBP binding loops; other site
697281003267	ABC-ATPase subunit interface; other site
697281003268	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
697281003269	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
697281003270	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281003271	dimerization interface [polypeptide binding]; other site
697281003272	Histidine kinase; Region: His_kinase; pfam06580
697281003273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281003274	ATP binding site [chemical binding]; other site
697281003275	Mg2+ binding site [ion binding]; other site
697281003276	G-X-G motif; other site
697281003277	Response regulator receiver domain; Region: Response_reg; pfam00072
697281003278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281003279	active site
697281003280	phosphorylation site [posttranslational modification]
697281003281	intermolecular recognition site; other site
697281003282	dimerization interface [polypeptide binding]; other site
697281003283	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281003284	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281003285	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281003286	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
697281003287	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281003288	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281003289	alpha-galactosidase; Region: PLN02808; cl17638
697281003290	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
697281003291	Predicted membrane protein [Function unknown]; Region: COG2119
697281003292	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
697281003293	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
697281003294	ATP cone domain; Region: ATP-cone; pfam03477
697281003295	Class III ribonucleotide reductase; Region: RNR_III; cd01675
697281003296	effector binding site; other site
697281003297	active site
697281003298	Zn binding site [ion binding]; other site
697281003299	glycine loop; other site
697281003300	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
697281003301	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281003302	FeS/SAM binding site; other site
697281003303	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
697281003304	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
697281003305	putative dimer interface [polypeptide binding]; other site
697281003306	active site pocket [active]
697281003307	putative cataytic base [active]
697281003308	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
697281003309	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
697281003310	Sensory domain found in PocR; Region: PocR; pfam10114
697281003311	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281003312	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281003313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281003314	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
697281003315	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
697281003316	substrate binding pocket [chemical binding]; other site
697281003317	dimer interface [polypeptide binding]; other site
697281003318	inhibitor binding site; inhibition site
697281003319	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
697281003320	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
697281003321	B12 binding site [chemical binding]; other site
697281003322	cobalt ligand [ion binding]; other site
697281003323	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
697281003324	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
697281003325	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
697281003326	catalytic loop [active]
697281003327	iron binding site [ion binding]; other site
697281003328	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
697281003329	putative catalytic site [active]
697281003330	putative metal binding site [ion binding]; other site
697281003331	putative phosphate binding site [ion binding]; other site
697281003332	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
697281003333	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
697281003334	dimer interface [polypeptide binding]; other site
697281003335	active site residues [active]
697281003336	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
697281003337	hypothetical protein; Provisional; Region: PRK13665
697281003338	YabP family; Region: YabP; pfam07873
697281003339	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
697281003340	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
697281003341	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
697281003342	PhoH-like protein; Region: PhoH; pfam02562
697281003343	metal-binding heat shock protein; Provisional; Region: PRK00016
697281003344	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
697281003345	active site
697281003346	catalytic motif [active]
697281003347	Zn binding site [ion binding]; other site
697281003348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
697281003349	putative substrate translocation pore; other site
697281003350	Major Facilitator Superfamily; Region: MFS_1; pfam07690
697281003351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
697281003352	Major Facilitator Superfamily; Region: MFS_1; pfam07690
697281003353	putative substrate translocation pore; other site
697281003354	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
697281003355	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
697281003356	homotrimer interface [polypeptide binding]; other site
697281003357	Walker A motif; other site
697281003358	GTP binding site [chemical binding]; other site
697281003359	Walker B motif; other site
697281003360	cobalamin synthase; Reviewed; Region: cobS; PRK00235
697281003361	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
697281003362	conserved cys residue [active]
697281003363	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
697281003364	YceG-like family; Region: YceG; pfam02618
697281003365	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
697281003366	dimerization interface [polypeptide binding]; other site
697281003367	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
697281003368	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
697281003369	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
697281003370	RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885
697281003371	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281003372	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281003373	DNA binding residues [nucleotide binding]
697281003374	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281003375	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281003376	DNA binding site [nucleotide binding]
697281003377	domain linker motif; other site
697281003378	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281003379	dimerization interface [polypeptide binding]; other site
697281003380	ligand binding site [chemical binding]; other site
697281003381	Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_3; cd11750
697281003382	Protein of unknown function, DUF608; Region: DUF608; pfam04685
697281003383	endoglucanase; Region: PLN02420
697281003384	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
697281003385	Cellulose binding domain; Region: CBM_3; pfam00942
697281003386	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
697281003387	Interdomain contacts; other site
697281003388	Cytokine receptor motif; other site
697281003389	Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011
697281003390	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
697281003391	Interdomain contacts; other site
697281003392	Cytokine receptor motif; other site
697281003393	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
697281003394	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
697281003395	Interdomain contacts; other site
697281003396	Cytokine receptor motif; other site
697281003397	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
697281003398	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
697281003399	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
697281003400	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
697281003401	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
697281003402	Interdomain contacts; other site
697281003403	Cytokine receptor motif; other site
697281003404	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
697281003405	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
697281003406	Interdomain contacts; other site
697281003407	Cytokine receptor motif; other site
697281003408	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
697281003409	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
697281003410	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
697281003411	Interdomain contacts; other site
697281003412	Cytokine receptor motif; other site
697281003413	endoglucanase; Region: PLN02420
697281003414	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
697281003415	Cellulose binding domain; Region: CBM_3; smart01067
697281003416	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
697281003417	Interdomain contacts; other site
697281003418	Cytokine receptor motif; other site
697281003419	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281003420	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281003421	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
697281003422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003423	dimer interface [polypeptide binding]; other site
697281003424	putative PBP binding loops; other site
697281003425	ABC-ATPase subunit interface; other site
697281003426	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281003427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003428	dimer interface [polypeptide binding]; other site
697281003429	conserved gate region; other site
697281003430	putative PBP binding loops; other site
697281003431	ABC-ATPase subunit interface; other site
697281003432	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
697281003433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
697281003434	active site
697281003435	motif I; other site
697281003436	motif II; other site
697281003437	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
697281003438	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
697281003439	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
697281003440	shikimate binding site; other site
697281003441	NAD(P) binding site [chemical binding]; other site
697281003442	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
697281003443	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
697281003444	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
697281003445	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
697281003446	nucleotide binding site [chemical binding]; other site
697281003447	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
697281003448	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
697281003449	shikimate kinase; Reviewed; Region: aroK; PRK00131
697281003450	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
697281003451	ADP binding site [chemical binding]; other site
697281003452	magnesium binding site [ion binding]; other site
697281003453	putative shikimate binding site; other site
697281003454	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
697281003455	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
697281003456	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
697281003457	Walker A motif; other site
697281003458	ATP binding site [chemical binding]; other site
697281003459	Walker B motif; other site
697281003460	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
697281003461	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
697281003462	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
697281003463	Walker A motif; other site
697281003464	ATP binding site [chemical binding]; other site
697281003465	Walker B motif; other site
697281003466	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
697281003467	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
697281003468	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
697281003469	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
697281003470	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
697281003471	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
697281003472	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
697281003473	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
697281003474	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
697281003475	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
697281003476	Late competence development protein ComFB; Region: ComFB; pfam10719
697281003477	AP endonuclease family 2; Region: AP2Ec; smart00518
697281003478	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
697281003479	Metal-binding active site; metal-binding site
697281003480	AP (apurinic/apyrimidinic) site pocket; other site
697281003481	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
697281003482	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
697281003483	dimerization interface [polypeptide binding]; other site
697281003484	active site
697281003485	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
697281003486	L-aspartate oxidase; Provisional; Region: PRK06175
697281003487	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
697281003488	Quinolinate synthetase A protein; Region: NadA; pfam02445
697281003489	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
697281003490	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
697281003491	active site
697281003492	intersubunit interface [polypeptide binding]; other site
697281003493	catalytic residue [active]
697281003494	Membrane transport protein; Region: Mem_trans; pfam03547
697281003495	cyanophycin synthetase; Provisional; Region: PRK14016
697281003496	ATP-grasp domain; Region: ATP-grasp_4; cl17255
697281003497	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
697281003498	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
697281003499	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
697281003500	proposed catalytic triad [active]
697281003501	active site nucleophile [active]
697281003502	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281003503	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281003504	DNA binding site [nucleotide binding]
697281003505	domain linker motif; other site
697281003506	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
697281003507	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281003508	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281003509	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281003510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003511	dimer interface [polypeptide binding]; other site
697281003512	putative PBP binding loops; other site
697281003513	ABC-ATPase subunit interface; other site
697281003514	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281003515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003516	dimer interface [polypeptide binding]; other site
697281003517	conserved gate region; other site
697281003518	putative PBP binding loops; other site
697281003519	ABC-ATPase subunit interface; other site
697281003520	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
697281003521	SLBB domain; Region: SLBB; pfam10531
697281003522	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
697281003523	FMN-binding domain; Region: FMN_bind; cl01081
697281003524	electron transport complex RsxE subunit; Provisional; Region: PRK12405
697281003525	Predicted NADH:ubiquinone oxidoreductase, subunit RnfA [Energy production and conversion]; Region: RnfA; COG4657
697281003526	ferredoxin; Validated; Region: PRK07118
697281003527	Putative Fe-S cluster; Region: FeS; cl17515
697281003528	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
697281003529	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
697281003530	homodecamer interface [polypeptide binding]; other site
697281003531	GTP cyclohydrolase I; Provisional; Region: PLN03044
697281003532	active site
697281003533	putative catalytic site residues [active]
697281003534	zinc binding site [ion binding]; other site
697281003535	GTP-CH-I/GFRP interaction surface; other site
697281003536	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
697281003537	Zn2+ binding site [ion binding]; other site
697281003538	Mg2+ binding site [ion binding]; other site
697281003539	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
697281003540	dihydropteroate synthase; Region: DHPS; TIGR01496
697281003541	substrate binding pocket [chemical binding]; other site
697281003542	dimer interface [polypeptide binding]; other site
697281003543	inhibitor binding site; inhibition site
697281003544	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
697281003545	homooctamer interface [polypeptide binding]; other site
697281003546	active site
697281003547	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
697281003548	catalytic center binding site [active]
697281003549	ATP binding site [chemical binding]; other site
697281003550	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
697281003551	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
697281003552	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
697281003553	active site
697281003554	HIGH motif; other site
697281003555	dimer interface [polypeptide binding]; other site
697281003556	KMSKS motif; other site
697281003557	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
697281003558	RNA binding surface [nucleotide binding]; other site
697281003559	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
697281003560	active site
697281003561	Ap6A binding site [chemical binding]; other site
697281003562	nudix motif; other site
697281003563	metal binding site [ion binding]; metal-binding site
697281003564	Uncharacterized conserved protein [Function unknown]; Region: COG1739
697281003565	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
697281003566	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
697281003567	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
697281003568	stage V sporulation protein AD; Validated; Region: PRK08304
697281003569	stage V sporulation protein AD; Provisional; Region: PRK12404
697281003570	SpoVA protein; Region: SpoVA; cl04298
697281003571	Transglycosylase; Region: Transgly; pfam00912
697281003572	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
697281003573	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
697281003574	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
697281003575	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281003576	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281003577	DNA binding residues [nucleotide binding]
697281003578	Putative zinc-finger; Region: zf-HC2; pfam13490
697281003579	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
697281003580	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
697281003581	Major Facilitator Superfamily; Region: MFS_1; pfam07690
697281003582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
697281003583	putative substrate translocation pore; other site
697281003584	DNA polymerase I; Provisional; Region: PRK05755
697281003585	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
697281003586	active site
697281003587	metal binding site 1 [ion binding]; metal-binding site
697281003588	putative 5' ssDNA interaction site; other site
697281003589	metal binding site 3; metal-binding site
697281003590	metal binding site 2 [ion binding]; metal-binding site
697281003591	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
697281003592	putative DNA binding site [nucleotide binding]; other site
697281003593	putative metal binding site [ion binding]; other site
697281003594	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
697281003595	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
697281003596	active site
697281003597	DNA binding site [nucleotide binding]
697281003598	catalytic site [active]
697281003599	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
697281003600	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
697281003601	CoA-binding site [chemical binding]; other site
697281003602	ATP-binding [chemical binding]; other site
697281003603	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
697281003604	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
697281003605	N-acetyl-D-glucosamine binding site [chemical binding]; other site
697281003606	catalytic residue [active]
697281003607	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
697281003608	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
697281003609	inhibitor binding site; inhibition site
697281003610	catalytic Zn binding site [ion binding]; other site
697281003611	structural Zn binding site [ion binding]; other site
697281003612	NADP binding site [chemical binding]; other site
697281003613	tetramer interface [polypeptide binding]; other site
697281003614	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
697281003615	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281003616	dimerization interface [polypeptide binding]; other site
697281003617	Histidine kinase; Region: His_kinase; pfam06580
697281003618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281003619	ATP binding site [chemical binding]; other site
697281003620	Mg2+ binding site [ion binding]; other site
697281003621	G-X-G motif; other site
697281003622	Response regulator receiver domain; Region: Response_reg; pfam00072
697281003623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281003624	active site
697281003625	phosphorylation site [posttranslational modification]
697281003626	intermolecular recognition site; other site
697281003627	dimerization interface [polypeptide binding]; other site
697281003628	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281003629	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281003630	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281003631	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281003632	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
697281003633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003634	dimer interface [polypeptide binding]; other site
697281003635	conserved gate region; other site
697281003636	putative PBP binding loops; other site
697281003637	ABC-ATPase subunit interface; other site
697281003638	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281003639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003640	dimer interface [polypeptide binding]; other site
697281003641	conserved gate region; other site
697281003642	putative PBP binding loops; other site
697281003643	ABC-ATPase subunit interface; other site
697281003644	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
697281003645	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
697281003646	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
697281003647	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
697281003648	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
697281003649	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
697281003650	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
697281003651	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281003652	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281003653	DNA binding site [nucleotide binding]
697281003654	domain linker motif; other site
697281003655	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281003656	ligand binding site [chemical binding]; other site
697281003657	dimerization interface [polypeptide binding]; other site
697281003658	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
697281003659	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
697281003660	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
697281003661	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
697281003662	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
697281003663	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
697281003664	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
697281003665	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
697281003666	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
697281003667	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
697281003668	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
697281003669	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003670	dimer interface [polypeptide binding]; other site
697281003671	conserved gate region; other site
697281003672	putative PBP binding loops; other site
697281003673	ABC-ATPase subunit interface; other site
697281003674	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
697281003675	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
697281003676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003677	dimer interface [polypeptide binding]; other site
697281003678	putative PBP binding loops; other site
697281003679	ABC-ATPase subunit interface; other site
697281003680	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
697281003681	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
697281003682	Walker A/P-loop; other site
697281003683	ATP binding site [chemical binding]; other site
697281003684	Q-loop/lid; other site
697281003685	ABC transporter signature motif; other site
697281003686	Walker B; other site
697281003687	D-loop; other site
697281003688	H-loop/switch region; other site
697281003689	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
697281003690	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
697281003691	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
697281003692	Walker A/P-loop; other site
697281003693	ATP binding site [chemical binding]; other site
697281003694	Q-loop/lid; other site
697281003695	ABC transporter signature motif; other site
697281003696	Walker B; other site
697281003697	D-loop; other site
697281003698	H-loop/switch region; other site
697281003699	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
697281003700	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
697281003701	FtsX-like permease family; Region: FtsX; pfam02687
697281003702	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
697281003703	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
697281003704	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
697281003705	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281003706	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281003707	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
697281003708	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
697281003709	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
697281003710	Sulfatase; Region: Sulfatase; cl17466
697281003711	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281003712	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281003713	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
697281003714	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
697281003715	Sulfatase; Region: Sulfatase; pfam00884
697281003716	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281003717	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281003718	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
697281003719	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
697281003720	Cupin domain; Region: Cupin_2; pfam07883
697281003721	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281003722	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281003723	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281003724	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
697281003725	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281003726	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281003727	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
697281003728	N- and C-terminal domain interface [polypeptide binding]; other site
697281003729	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
697281003730	active site
697281003731	putative catalytic site [active]
697281003732	metal binding site [ion binding]; metal-binding site
697281003733	ATP binding site [chemical binding]; other site
697281003734	carbohydrate binding site [chemical binding]; other site
697281003735	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
697281003736	HlyD family secretion protein; Region: HlyD_3; pfam13437
697281003737	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
697281003738	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
697281003739	active site
697281003740	catalytic site [active]
697281003741	metal binding site [ion binding]; metal-binding site
697281003742	dimer interface [polypeptide binding]; other site
697281003743	Protein of unknown function, DUF624; Region: DUF624; cl02369
697281003744	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
697281003745	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
697281003746	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
697281003747	catalytic triad [active]
697281003748	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
697281003749	putative active site [active]
697281003750	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
697281003751	Precorrin-8X methylmutase; Region: CbiC; pfam02570
697281003752	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
697281003753	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
697281003754	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
697281003755	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636
697281003756	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
697281003757	Walker A/P-loop; other site
697281003758	ATP binding site [chemical binding]; other site
697281003759	Q-loop/lid; other site
697281003760	ABC transporter signature motif; other site
697281003761	Walker B; other site
697281003762	D-loop; other site
697281003763	H-loop/switch region; other site
697281003764	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
697281003765	active site
697281003766	putative homodimer interface [polypeptide binding]; other site
697281003767	SAM binding site [chemical binding]; other site
697281003768	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
697281003769	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
697281003770	S-adenosylmethionine binding site [chemical binding]; other site
697281003771	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
697281003772	active site
697281003773	SAM binding site [chemical binding]; other site
697281003774	homodimer interface [polypeptide binding]; other site
697281003775	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
697281003776	active site
697281003777	SAM binding site [chemical binding]; other site
697281003778	homodimer interface [polypeptide binding]; other site
697281003779	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
697281003780	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
697281003781	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
697281003782	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
697281003783	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
697281003784	active site
697281003785	SAM binding site [chemical binding]; other site
697281003786	homodimer interface [polypeptide binding]; other site
697281003787	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
697281003788	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
697281003789	tRNA; other site
697281003790	putative tRNA binding site [nucleotide binding]; other site
697281003791	putative NADP binding site [chemical binding]; other site
697281003792	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
697281003793	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
697281003794	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
697281003795	domain interfaces; other site
697281003796	active site
697281003797	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
697281003798	active site
697281003799	SAM binding site [chemical binding]; other site
697281003800	homodimer interface [polypeptide binding]; other site
697281003801	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
697281003802	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
697281003803	active site
697281003804	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
697281003805	dimer interface [polypeptide binding]; other site
697281003806	active site
697281003807	Schiff base residues; other site
697281003808	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
697281003809	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
697281003810	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
697281003811	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
697281003812	inhibitor-cofactor binding pocket; inhibition site
697281003813	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281003814	catalytic residue [active]
697281003815	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
697281003816	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
697281003817	metal-binding site [ion binding]
697281003818	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
697281003819	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
697281003820	metal-binding site [ion binding]
697281003821	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
697281003822	Soluble P-type ATPase [General function prediction only]; Region: COG4087
697281003823	UbiA prenyltransferase family; Region: UbiA; pfam01040
697281003824	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
697281003825	Sporulation related domain; Region: SPOR; pfam05036
697281003826	DRTGG domain; Region: DRTGG; pfam07085
697281003827	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
697281003828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
697281003829	ATP binding site [chemical binding]; other site
697281003830	G-X-G motif; other site
697281003831	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
697281003832	4Fe-4S binding domain; Region: Fer4_6; pfam12837
697281003833	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
697281003834	Putative Fe-S cluster; Region: FeS; cl17515
697281003835	DRTGG domain; Region: DRTGG; pfam07085
697281003836	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
697281003837	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
697281003838	putative dimer interface [polypeptide binding]; other site
697281003839	[2Fe-2S] cluster binding site [ion binding]; other site
697281003840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
697281003841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281003842	ATP binding site [chemical binding]; other site
697281003843	Mg2+ binding site [ion binding]; other site
697281003844	G-X-G motif; other site
697281003845	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
697281003846	dimer interface [polypeptide binding]; other site
697281003847	[2Fe-2S] cluster binding site [ion binding]; other site
697281003848	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
697281003849	dimer interface [polypeptide binding]; other site
697281003850	[2Fe-2S] cluster binding site [ion binding]; other site
697281003851	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
697281003852	SLBB domain; Region: SLBB; pfam10531
697281003853	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
697281003854	4Fe-4S binding domain; Region: Fer4; pfam00037
697281003855	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
697281003856	4Fe-4S binding domain; Region: Fer4; pfam00037
697281003857	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
697281003858	catalytic loop [active]
697281003859	iron binding site [ion binding]; other site
697281003860	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
697281003861	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
697281003862	4Fe-4S binding domain; Region: Fer4; pfam00037
697281003863	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
697281003864	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
697281003865	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
697281003866	ParB-like nuclease domain; Region: ParBc; pfam02195
697281003867	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
697281003868	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
697281003869	HIGH motif; other site
697281003870	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
697281003871	active site
697281003872	KMSKS motif; other site
697281003873	Predicted membrane protein [Function unknown]; Region: COG2323
697281003874	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
697281003875	metal-binding site [ion binding]
697281003876	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
697281003877	ZIP Zinc transporter; Region: Zip; pfam02535
697281003878	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
697281003879	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
697281003880	Glycoprotease family; Region: Peptidase_M22; pfam00814
697281003881	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
697281003882	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
697281003883	Coenzyme A binding pocket [chemical binding]; other site
697281003884	UGMP family protein; Validated; Region: PRK09604
697281003885	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
697281003886	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
697281003887	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
697281003888	Walker A/P-loop; other site
697281003889	ATP binding site [chemical binding]; other site
697281003890	Q-loop/lid; other site
697281003891	ABC transporter signature motif; other site
697281003892	Walker B; other site
697281003893	D-loop; other site
697281003894	H-loop/switch region; other site
697281003895	Predicted transcriptional regulators [Transcription]; Region: COG1725
697281003896	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
697281003897	DNA-binding site [nucleotide binding]; DNA binding site
697281003898	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
697281003899	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
697281003900	Walker A/P-loop; other site
697281003901	ATP binding site [chemical binding]; other site
697281003902	Q-loop/lid; other site
697281003903	ABC transporter signature motif; other site
697281003904	Walker B; other site
697281003905	D-loop; other site
697281003906	H-loop/switch region; other site
697281003907	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
697281003908	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
697281003909	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281003910	Walker A/P-loop; other site
697281003911	ATP binding site [chemical binding]; other site
697281003912	Q-loop/lid; other site
697281003913	ABC transporter signature motif; other site
697281003914	Walker B; other site
697281003915	D-loop; other site
697281003916	H-loop/switch region; other site
697281003917	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
697281003918	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
697281003919	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
697281003920	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
697281003921	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
697281003922	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
697281003923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281003924	active site
697281003925	phosphorylation site [posttranslational modification]
697281003926	intermolecular recognition site; other site
697281003927	dimerization interface [polypeptide binding]; other site
697281003928	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
697281003929	DNA binding site [nucleotide binding]
697281003930	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
697281003931	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281003932	dimerization interface [polypeptide binding]; other site
697281003933	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
697281003934	dimer interface [polypeptide binding]; other site
697281003935	phosphorylation site [posttranslational modification]
697281003936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281003937	ATP binding site [chemical binding]; other site
697281003938	Mg2+ binding site [ion binding]; other site
697281003939	G-X-G motif; other site
697281003940	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
697281003941	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
697281003942	NodB motif; other site
697281003943	active site
697281003944	catalytic site [active]
697281003945	metal binding site [ion binding]; metal-binding site
697281003946	Uncharacterized conserved protein [Function unknown]; Region: COG1543
697281003947	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
697281003948	active site
697281003949	substrate binding site [chemical binding]; other site
697281003950	catalytic site [active]
697281003951	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
697281003952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
697281003953	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
697281003954	Domain interface; other site
697281003955	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
697281003956	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
697281003957	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
697281003958	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
697281003959	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
697281003960	Protein of unknown function (DUF964); Region: DUF964; pfam06133
697281003961	QueT transporter; Region: QueT; pfam06177
697281003962	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
697281003963	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
697281003964	G1 box; other site
697281003965	putative GEF interaction site [polypeptide binding]; other site
697281003966	GTP/Mg2+ binding site [chemical binding]; other site
697281003967	Switch I region; other site
697281003968	G2 box; other site
697281003969	G3 box; other site
697281003970	Switch II region; other site
697281003971	G4 box; other site
697281003972	G5 box; other site
697281003973	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
697281003974	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
697281003975	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
697281003976	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
697281003977	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
697281003978	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
697281003979	minor groove reading motif; other site
697281003980	helix-hairpin-helix signature motif; other site
697281003981	substrate binding pocket [chemical binding]; other site
697281003982	active site
697281003983	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
697281003984	SLBB domain; Region: SLBB; pfam10531
697281003985	Helix-hairpin-helix motif; Region: HHH; pfam00633
697281003986	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
697281003987	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281003988	non-specific DNA binding site [nucleotide binding]; other site
697281003989	salt bridge; other site
697281003990	sequence-specific DNA binding site [nucleotide binding]; other site
697281003991	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281003992	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281003993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003994	dimer interface [polypeptide binding]; other site
697281003995	conserved gate region; other site
697281003996	ABC-ATPase subunit interface; other site
697281003997	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281003998	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281003999	dimer interface [polypeptide binding]; other site
697281004000	conserved gate region; other site
697281004001	putative PBP binding loops; other site
697281004002	ABC-ATPase subunit interface; other site
697281004003	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
697281004004	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281004005	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281004006	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281004007	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
697281004008	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
697281004009	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
697281004010	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
697281004011	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281004012	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281004013	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281004014	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
697281004015	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
697281004016	Metal-binding active site; metal-binding site
697281004017	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281004018	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281004019	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281004020	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281004021	Biotin operon repressor [Transcription]; Region: BirA; COG1654
697281004022	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
697281004023	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
697281004024	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
697281004025	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
697281004026	putative active site pocket [active]
697281004027	cleavage site
697281004028	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281004029	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
697281004030	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
697281004031	Walker A/P-loop; other site
697281004032	ATP binding site [chemical binding]; other site
697281004033	Q-loop/lid; other site
697281004034	ABC transporter signature motif; other site
697281004035	Walker B; other site
697281004036	D-loop; other site
697281004037	H-loop/switch region; other site
697281004038	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
697281004039	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
697281004040	DNA methylase; Region: N6_N4_Mtase; pfam01555
697281004041	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281004042	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281004043	DNA binding site [nucleotide binding]
697281004044	domain linker motif; other site
697281004045	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281004046	dimerization interface [polypeptide binding]; other site
697281004047	ligand binding site [chemical binding]; other site
697281004048	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
697281004049	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281004050	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281004051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281004052	dimer interface [polypeptide binding]; other site
697281004053	conserved gate region; other site
697281004054	putative PBP binding loops; other site
697281004055	ABC-ATPase subunit interface; other site
697281004056	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281004057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281004058	dimer interface [polypeptide binding]; other site
697281004059	conserved gate region; other site
697281004060	putative PBP binding loops; other site
697281004061	ABC-ATPase subunit interface; other site
697281004062	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
697281004063	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
697281004064	active site
697281004065	metal binding site [ion binding]; metal-binding site
697281004066	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
697281004067	intersubunit interface [polypeptide binding]; other site
697281004068	active site
697281004069	zinc binding site [ion binding]; other site
697281004070	Na+ binding site [ion binding]; other site
697281004071	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
697281004072	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
697281004073	inhibitor site; inhibition site
697281004074	active site
697281004075	dimer interface [polypeptide binding]; other site
697281004076	catalytic residue [active]
697281004077	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
697281004078	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
697281004079	ligand binding site [chemical binding]; other site
697281004080	NAD binding site [chemical binding]; other site
697281004081	dimerization interface [polypeptide binding]; other site
697281004082	catalytic site [active]
697281004083	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
697281004084	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
697281004085	motif II; other site
697281004086	Cupin domain; Region: Cupin_2; pfam07883
697281004087	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
697281004088	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
697281004089	tetramerization interface [polypeptide binding]; other site
697281004090	NAD(P) binding site [chemical binding]; other site
697281004091	catalytic residues [active]
697281004092	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
697281004093	D-xylulose kinase; Region: XylB; TIGR01312
697281004094	N- and C-terminal domain interface [polypeptide binding]; other site
697281004095	active site
697281004096	MgATP binding site [chemical binding]; other site
697281004097	catalytic site [active]
697281004098	metal binding site [ion binding]; metal-binding site
697281004099	xylulose binding site [chemical binding]; other site
697281004100	homodimer interface [polypeptide binding]; other site
697281004101	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
697281004102	trimer interface [polypeptide binding]; other site
697281004103	putative Zn binding site [ion binding]; other site
697281004104	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
697281004105	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
697281004106	FAD binding site [chemical binding]; other site
697281004107	homotetramer interface [polypeptide binding]; other site
697281004108	substrate binding pocket [chemical binding]; other site
697281004109	catalytic base [active]
697281004110	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
697281004111	Ligand binding site [chemical binding]; other site
697281004112	Electron transfer flavoprotein domain; Region: ETF; pfam01012
697281004113	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
697281004114	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
697281004115	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
697281004116	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
697281004117	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
697281004118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
697281004119	Probable transposase; Region: OrfB_IS605; pfam01385
697281004120	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
697281004121	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
697281004122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281004123	active site
697281004124	phosphorylation site [posttranslational modification]
697281004125	intermolecular recognition site; other site
697281004126	dimerization interface [polypeptide binding]; other site
697281004127	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281004128	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281004129	dimerization interface [polypeptide binding]; other site
697281004130	Histidine kinase; Region: His_kinase; pfam06580
697281004131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281004132	ATP binding site [chemical binding]; other site
697281004133	Mg2+ binding site [ion binding]; other site
697281004134	G-X-G motif; other site
697281004135	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281004136	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281004137	dimer interface [polypeptide binding]; other site
697281004138	conserved gate region; other site
697281004139	ABC-ATPase subunit interface; other site
697281004140	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281004141	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281004142	conserved gate region; other site
697281004143	ABC-ATPase subunit interface; other site
697281004144	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281004145	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
697281004146	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
697281004147	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
697281004148	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
697281004149	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
697281004150	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281004151	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281004152	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281004153	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281004154	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281004155	dimer interface [polypeptide binding]; other site
697281004156	conserved gate region; other site
697281004157	ABC-ATPase subunit interface; other site
697281004158	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281004159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281004160	dimer interface [polypeptide binding]; other site
697281004161	ABC-ATPase subunit interface; other site
697281004162	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281004163	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
697281004164	Interdomain contacts; other site
697281004165	Cytokine receptor motif; other site
697281004166	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
697281004167	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
697281004168	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
697281004169	Transcriptional regulator [Transcription]; Region: IclR; COG1414
697281004170	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281004171	putative Zn2+ binding site [ion binding]; other site
697281004172	putative DNA binding site [nucleotide binding]; other site
697281004173	Bacterial transcriptional regulator; Region: IclR; pfam01614
697281004174	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
697281004175	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
697281004176	Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208
697281004177	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281004178	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281004179	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281004180	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
697281004181	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
697281004182	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
697281004183	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
697281004184	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
697281004185	catalytic residue [active]
697281004186	Protein of unknown function (DUF552); Region: DUF552; pfam04472
697281004187	YGGT family; Region: YGGT; pfam02325
697281004188	DivIVA protein; Region: DivIVA; pfam05103
697281004189	DivIVA domain; Region: DivI1A_domain; TIGR03544
697281004190	V-type ATP synthase subunit E; Provisional; Region: PRK01558
697281004191	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
697281004192	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
697281004193	HIGH motif; other site
697281004194	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
697281004195	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
697281004196	active site
697281004197	KMSKS motif; other site
697281004198	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
697281004199	tRNA binding surface [nucleotide binding]; other site
697281004200	anticodon binding site; other site
697281004201	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
697281004202	hypothetical protein; Provisional; Region: PRK08609
697281004203	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
697281004204	active site
697281004205	primer binding site [nucleotide binding]; other site
697281004206	NTP  binding site [chemical binding]; other site
697281004207	metal binding triad [ion binding]; metal-binding site
697281004208	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
697281004209	active site
697281004210	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
697281004211	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
697281004212	motif 1; other site
697281004213	active site
697281004214	motif 2; other site
697281004215	motif 3; other site
697281004216	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
697281004217	DHHA1 domain; Region: DHHA1; pfam02272
697281004218	Protein of unknown function DUF89; Region: DUF89; cl15397
697281004219	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
697281004220	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
697281004221	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
697281004222	Predicted transcriptional regulator [Transcription]; Region: COG1959
697281004223	Transcriptional regulator; Region: Rrf2; cl17282
697281004224	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
697281004225	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
697281004226	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
697281004227	catalytic residue [active]
697281004228	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
697281004229	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
697281004230	trimerization site [polypeptide binding]; other site
697281004231	active site
697281004232	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
697281004233	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
697281004234	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
697281004235	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
697281004236	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281004237	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281004238	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
697281004239	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
697281004240	Cache domain; Region: Cache_1; pfam02743
697281004241	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281004242	dimerization interface [polypeptide binding]; other site
697281004243	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
697281004244	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
697281004245	dimer interface [polypeptide binding]; other site
697281004246	putative CheW interface [polypeptide binding]; other site
697281004247	Methyltransferase domain; Region: Methyltransf_23; pfam13489
697281004248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
697281004249	S-adenosylmethionine binding site [chemical binding]; other site
697281004250	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
697281004251	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
697281004252	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
697281004253	Zn2+ binding site [ion binding]; other site
697281004254	Mg2+ binding site [ion binding]; other site
697281004255	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
697281004256	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
697281004257	TMP-binding site; other site
697281004258	ATP-binding site [chemical binding]; other site
697281004259	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
697281004260	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
697281004261	TMP-binding site; other site
697281004262	ATP-binding site [chemical binding]; other site
697281004263	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
697281004264	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
697281004265	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
697281004266	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
697281004267	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
697281004268	motif II; other site
697281004269	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
697281004270	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
697281004271	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
697281004272	active site
697281004273	substrate binding site [chemical binding]; other site
697281004274	metal binding site [ion binding]; metal-binding site
697281004275	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
697281004276	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
697281004277	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
697281004278	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
697281004279	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
697281004280	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
697281004281	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
697281004282	glyoxylate reductase; Reviewed; Region: PRK13243
697281004283	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
697281004284	dimerization interface [polypeptide binding]; other site
697281004285	ligand binding site [chemical binding]; other site
697281004286	NADP binding site [chemical binding]; other site
697281004287	catalytic site [active]
697281004288	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
697281004289	intersubunit interface [polypeptide binding]; other site
697281004290	active site
697281004291	zinc binding site [ion binding]; other site
697281004292	Na+ binding site [ion binding]; other site
697281004293	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
697281004294	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
697281004295	N- and C-terminal domain interface [polypeptide binding]; other site
697281004296	putative active site [active]
697281004297	MgATP binding site [chemical binding]; other site
697281004298	catalytic site [active]
697281004299	metal binding site [ion binding]; metal-binding site
697281004300	putative xylulose binding site [chemical binding]; other site
697281004301	putative homodimer interface [polypeptide binding]; other site
697281004302	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
697281004303	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
697281004304	NAD(P) binding site [chemical binding]; other site
697281004305	active site
697281004306	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
697281004307	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
697281004308	CoA binding domain; Region: CoA_binding; pfam02629
697281004309	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
697281004310	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
697281004311	catalytic loop [active]
697281004312	iron binding site [ion binding]; other site
697281004313	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
697281004314	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
697281004315	4Fe-4S binding domain; Region: Fer4; pfam00037
697281004316	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
697281004317	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
697281004318	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
697281004319	SLBB domain; Region: SLBB; pfam10531
697281004320	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
697281004321	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
697281004322	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
697281004323	putative dimer interface [polypeptide binding]; other site
697281004324	[2Fe-2S] cluster binding site [ion binding]; other site
697281004325	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
697281004326	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
697281004327	Putative Fe-S cluster; Region: FeS; cl17515
697281004328	PAS domain; Region: PAS_9; pfam13426
697281004329	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
697281004330	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281004331	Walker A motif; other site
697281004332	ATP binding site [chemical binding]; other site
697281004333	Walker B motif; other site
697281004334	arginine finger; other site
697281004335	Helix-turn-helix domain; Region: HTH_28; pfam13518
697281004336	Winged helix-turn helix; Region: HTH_29; pfam13551
697281004337	Integrase core domain; Region: rve; pfam00665
697281004338	Integrase core domain; Region: rve_3; cl15866
697281004339	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
697281004340	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
697281004341	homodimer interface [polypeptide binding]; other site
697281004342	substrate-cofactor binding pocket; other site
697281004343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281004344	catalytic residue [active]
697281004345	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
697281004346	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
697281004347	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
697281004348	Aluminium resistance protein; Region: Alum_res; pfam06838
697281004349	Uncharacterized conserved protein [Function unknown]; Region: COG3350
697281004350	stage V sporulation protein K; Region: spore_V_K; TIGR02881
697281004351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281004352	Walker A motif; other site
697281004353	ATP binding site [chemical binding]; other site
697281004354	Walker B motif; other site
697281004355	arginine finger; other site
697281004356	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
697281004357	G1 box; other site
697281004358	GTP/Mg2+ binding site [chemical binding]; other site
697281004359	G2 box; other site
697281004360	Switch I region; other site
697281004361	G3 box; other site
697281004362	Switch II region; other site
697281004363	G4 box; other site
697281004364	G5 box; other site
697281004365	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
697281004366	LexA repressor; Validated; Region: PRK00215
697281004367	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
697281004368	Catalytic site [active]
697281004369	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
697281004370	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
697281004371	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
697281004372	active site
697281004373	DNA binding site [nucleotide binding]
697281004374	Int/Topo IB signature motif; other site
697281004375	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
697281004376	RNA/DNA hybrid binding site [nucleotide binding]; other site
697281004377	active site
697281004378	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
697281004379	pyrroline-5-carboxylate reductase; Region: PLN02688
697281004380	pyruvate kinase; Provisional; Region: PRK06354
697281004381	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
697281004382	domain interfaces; other site
697281004383	active site
697281004384	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
697281004385	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
697281004386	Walker A motif; other site
697281004387	ATP binding site [chemical binding]; other site
697281004388	Walker B motif; other site
697281004389	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
697281004390	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
697281004391	Spore germination protein; Region: Spore_permease; cl17796
697281004392	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
697281004393	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
697281004394	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
697281004395	dinuclear metal binding motif [ion binding]; other site
697281004396	Uncharacterized conserved protein [Function unknown]; Region: COG4198
697281004397	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
697281004398	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
697281004399	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764
697281004400	DNA binding residues [nucleotide binding]
697281004401	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
697281004402	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
697281004403	Beta-Casp domain; Region: Beta-Casp; smart01027
697281004404	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
697281004405	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
697281004406	Zn2+ binding site [ion binding]; other site
697281004407	Mg2+ binding site [ion binding]; other site
697281004408	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
697281004409	Zn2+ binding site [ion binding]; other site
697281004410	Mg2+ binding site [ion binding]; other site
697281004411	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
697281004412	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
697281004413	metal binding site [ion binding]; metal-binding site
697281004414	dimer interface [polypeptide binding]; other site
697281004415	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
697281004416	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
697281004417	active site
697281004418	NMT1-like family; Region: NMT1_2; pfam13379
697281004419	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
697281004420	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
697281004421	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
697281004422	Walker A/P-loop; other site
697281004423	ATP binding site [chemical binding]; other site
697281004424	Q-loop/lid; other site
697281004425	ABC transporter signature motif; other site
697281004426	Walker B; other site
697281004427	D-loop; other site
697281004428	H-loop/switch region; other site
697281004429	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
697281004430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281004431	dimer interface [polypeptide binding]; other site
697281004432	conserved gate region; other site
697281004433	putative PBP binding loops; other site
697281004434	ABC-ATPase subunit interface; other site
697281004435	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
697281004436	intersubunit interface [polypeptide binding]; other site
697281004437	active site
697281004438	Zn2+ binding site [ion binding]; other site
697281004439	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
697281004440	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281004441	putative DNA binding site [nucleotide binding]; other site
697281004442	putative Zn2+ binding site [ion binding]; other site
697281004443	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
697281004444	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
697281004445	active site
697281004446	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
697281004447	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
697281004448	heterodimer interface [polypeptide binding]; other site
697281004449	active site
697281004450	FMN binding site [chemical binding]; other site
697281004451	homodimer interface [polypeptide binding]; other site
697281004452	substrate binding site [chemical binding]; other site
697281004453	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
697281004454	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
697281004455	FAD binding pocket [chemical binding]; other site
697281004456	FAD binding motif [chemical binding]; other site
697281004457	phosphate binding motif [ion binding]; other site
697281004458	beta-alpha-beta structure motif; other site
697281004459	NAD binding pocket [chemical binding]; other site
697281004460	Iron coordination center [ion binding]; other site
697281004461	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
697281004462	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
697281004463	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
697281004464	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
697281004465	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
697281004466	ATP-grasp domain; Region: ATP-grasp_4; cl17255
697281004467	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
697281004468	IMP binding site; other site
697281004469	dimer interface [polypeptide binding]; other site
697281004470	interdomain contacts; other site
697281004471	partial ornithine binding site; other site
697281004472	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
697281004473	active site
697281004474	dimer interface [polypeptide binding]; other site
697281004475	dihydroorotase; Validated; Region: pyrC; PRK09357
697281004476	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
697281004477	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
697281004478	active site
697281004479	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
697281004480	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
697281004481	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
697281004482	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
697281004483	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
697281004484	active site
697281004485	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
697281004486	diiron binding motif [ion binding]; other site
697281004487	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
697281004488	CCC1-related family of proteins; Region: CCC1_like; cl00278
697281004489	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
697281004490	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
697281004491	Coenzyme A binding pocket [chemical binding]; other site
697281004492	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
697281004493	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
697281004494	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
697281004495	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
697281004496	putative catalytic cysteine [active]
697281004497	gamma-glutamyl kinase; Provisional; Region: PRK05429
697281004498	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
697281004499	nucleotide binding site [chemical binding]; other site
697281004500	homotetrameric interface [polypeptide binding]; other site
697281004501	putative phosphate binding site [ion binding]; other site
697281004502	putative allosteric binding site; other site
697281004503	PIN domain; Region: PIN_3; cl17397
697281004504	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
697281004505	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281004506	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
697281004507	Walker A/P-loop; other site
697281004508	ATP binding site [chemical binding]; other site
697281004509	Q-loop/lid; other site
697281004510	ABC transporter signature motif; other site
697281004511	Walker B; other site
697281004512	D-loop; other site
697281004513	H-loop/switch region; other site
697281004514	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281004515	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
697281004516	Walker A/P-loop; other site
697281004517	ATP binding site [chemical binding]; other site
697281004518	Q-loop/lid; other site
697281004519	ABC transporter signature motif; other site
697281004520	Walker B; other site
697281004521	D-loop; other site
697281004522	H-loop/switch region; other site
697281004523	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
697281004524	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
697281004525	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
697281004526	ScpA/B protein; Region: ScpA_ScpB; cl00598
697281004527	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
697281004528	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
697281004529	active site
697281004530	HIGH motif; other site
697281004531	dimer interface [polypeptide binding]; other site
697281004532	KMSKS motif; other site
697281004533	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
697281004534	Peptidase family M50; Region: Peptidase_M50; pfam02163
697281004535	active site
697281004536	putative substrate binding region [chemical binding]; other site
697281004537	diaminopimelate decarboxylase; Region: lysA; TIGR01048
697281004538	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
697281004539	active site
697281004540	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
697281004541	substrate binding site [chemical binding]; other site
697281004542	catalytic residues [active]
697281004543	dimer interface [polypeptide binding]; other site
697281004544	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
697281004545	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
697281004546	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
697281004547	purine nucleoside phosphorylase; Provisional; Region: PRK08202
697281004548	phosphopentomutase; Provisional; Region: PRK05362
697281004549	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
697281004550	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
697281004551	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
697281004552	active site
697281004553	DNA binding site [nucleotide binding]
697281004554	Int/Topo IB signature motif; other site
697281004555	Integral membrane protein DUF95; Region: DUF95; cl00572
697281004556	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
697281004557	dimer interface [polypeptide binding]; other site
697281004558	active site
697281004559	ADP-ribose binding site [chemical binding]; other site
697281004560	nudix motif; other site
697281004561	metal binding site [ion binding]; metal-binding site
697281004562	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
697281004563	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
697281004564	Mg++ binding site [ion binding]; other site
697281004565	putative catalytic motif [active]
697281004566	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
697281004567	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
697281004568	Ligand binding site; other site
697281004569	Putative Catalytic site; other site
697281004570	DXD motif; other site
697281004571	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
697281004572	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
697281004573	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
697281004574	Thiamine pyrophosphokinase; Region: TPK; cl08415
697281004575	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
697281004576	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
697281004577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281004578	active site
697281004579	phosphorylation site [posttranslational modification]
697281004580	intermolecular recognition site; other site
697281004581	dimerization interface [polypeptide binding]; other site
697281004582	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
697281004583	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
697281004584	nucleotide binding site [chemical binding]; other site
697281004585	Type III pantothenate kinase; Region: Pan_kinase; cl17198
697281004586	Predicted membrane protein [Function unknown]; Region: COG4684
697281004587	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
697281004588	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281004589	Radical SAM superfamily; Region: Radical_SAM; pfam04055
697281004590	FeS/SAM binding site; other site
697281004591	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
697281004592	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
697281004593	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
697281004594	N-acetyl-D-glucosamine binding site [chemical binding]; other site
697281004595	catalytic residue [active]
697281004596	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
697281004597	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
697281004598	active site
697281004599	motif I; other site
697281004600	motif II; other site
697281004601	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
697281004602	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
697281004603	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
697281004604	putative active site [active]
697281004605	PhoH-like protein; Region: PhoH; pfam02562
697281004606	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
697281004607	FOG: CBS domain [General function prediction only]; Region: COG0517
697281004608	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
697281004609	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
697281004610	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
697281004611	metal binding site [ion binding]; metal-binding site
697281004612	active site
697281004613	I-site; other site
697281004614	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
697281004615	active site
697281004616	metal binding site [ion binding]; metal-binding site
697281004617	dimerization interface [polypeptide binding]; other site
697281004618	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
697281004619	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
697281004620	active site
697281004621	HIGH motif; other site
697281004622	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
697281004623	KMSKS motif; other site
697281004624	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
697281004625	tRNA binding surface [nucleotide binding]; other site
697281004626	anticodon binding site; other site
697281004627	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
697281004628	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
697281004629	trimer interface [polypeptide binding]; other site
697281004630	active site
697281004631	substrate binding site [chemical binding]; other site
697281004632	CoA binding site [chemical binding]; other site
697281004633	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
697281004634	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
697281004635	active site
697281004636	metal binding site [ion binding]; metal-binding site
697281004637	enolase; Provisional; Region: eno; PRK00077
697281004638	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
697281004639	dimer interface [polypeptide binding]; other site
697281004640	metal binding site [ion binding]; metal-binding site
697281004641	substrate binding pocket [chemical binding]; other site
697281004642	phosphoglyceromutase; Provisional; Region: PRK05434
697281004643	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
697281004644	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
697281004645	triosephosphate isomerase; Provisional; Region: PRK14565
697281004646	substrate binding site [chemical binding]; other site
697281004647	dimer interface [polypeptide binding]; other site
697281004648	catalytic triad [active]
697281004649	Phosphoglycerate kinase; Region: PGK; pfam00162
697281004650	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
697281004651	substrate binding site [chemical binding]; other site
697281004652	hinge regions; other site
697281004653	ADP binding site [chemical binding]; other site
697281004654	catalytic site [active]
697281004655	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
697281004656	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
697281004657	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
697281004658	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
697281004659	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
697281004660	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
697281004661	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
697281004662	single-stranded DNA-binding protein; Provisional; Region: PRK05813
697281004663	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
697281004664	dimer interface [polypeptide binding]; other site
697281004665	ssDNA binding site [nucleotide binding]; other site
697281004666	tetramer (dimer of dimers) interface [polypeptide binding]; other site
697281004667	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
697281004668	NodB motif; other site
697281004669	active site
697281004670	catalytic site [active]
697281004671	metal binding site [ion binding]; metal-binding site
697281004672	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
697281004673	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
697281004674	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
697281004675	Nitrogen regulatory protein P-II; Region: P-II; smart00938
697281004676	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281004677	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281004678	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281004679	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
697281004680	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
697281004681	Double zinc ribbon; Region: DZR; pfam12773
697281004682	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
697281004683	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
697281004684	protein binding site [polypeptide binding]; other site
697281004685	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
697281004686	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281004687	dimerization interface [polypeptide binding]; other site
697281004688	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
697281004689	dimer interface [polypeptide binding]; other site
697281004690	phosphorylation site [posttranslational modification]
697281004691	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281004692	ATP binding site [chemical binding]; other site
697281004693	Mg2+ binding site [ion binding]; other site
697281004694	G-X-G motif; other site
697281004695	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
697281004696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281004697	active site
697281004698	phosphorylation site [posttranslational modification]
697281004699	intermolecular recognition site; other site
697281004700	dimerization interface [polypeptide binding]; other site
697281004701	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
697281004702	DNA binding site [nucleotide binding]
697281004703	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
697281004704	hypothetical protein; Provisional; Region: PRK06851
697281004705	hypothetical protein; Provisional; Region: PRK06761
697281004706	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
697281004707	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
697281004708	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
697281004709	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
697281004710	active site
697281004711	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
697281004712	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
697281004713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281004714	active site
697281004715	phosphorylation site [posttranslational modification]
697281004716	intermolecular recognition site; other site
697281004717	dimerization interface [polypeptide binding]; other site
697281004718	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281004719	Walker A motif; other site
697281004720	ATP binding site [chemical binding]; other site
697281004721	Walker B motif; other site
697281004722	arginine finger; other site
697281004723	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
697281004724	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
697281004725	dimer interface [polypeptide binding]; other site
697281004726	phosphorylation site [posttranslational modification]
697281004727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281004728	ATP binding site [chemical binding]; other site
697281004729	Mg2+ binding site [ion binding]; other site
697281004730	G-X-G motif; other site
697281004731	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
697281004732	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
697281004733	FtsX-like permease family; Region: FtsX; pfam02687
697281004734	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
697281004735	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
697281004736	Walker A/P-loop; other site
697281004737	ATP binding site [chemical binding]; other site
697281004738	Q-loop/lid; other site
697281004739	ABC transporter signature motif; other site
697281004740	Walker B; other site
697281004741	D-loop; other site
697281004742	H-loop/switch region; other site
697281004743	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
697281004744	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
697281004745	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
697281004746	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
697281004747	HlyD family secretion protein; Region: HlyD_3; pfam13437
697281004748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
697281004749	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
697281004750	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
697281004751	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
697281004752	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
697281004753	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
697281004754	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
697281004755	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
697281004756	catalytic residues [active]
697281004757	GTPase CgtA; Reviewed; Region: obgE; PRK12297
697281004758	GTP1/OBG; Region: GTP1_OBG; pfam01018
697281004759	Obg GTPase; Region: Obg; cd01898
697281004760	G1 box; other site
697281004761	GTP/Mg2+ binding site [chemical binding]; other site
697281004762	Switch I region; other site
697281004763	G2 box; other site
697281004764	G3 box; other site
697281004765	Switch II region; other site
697281004766	G4 box; other site
697281004767	G5 box; other site
697281004768	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
697281004769	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
697281004770	Protein of unknown function (DUF464); Region: DUF464; pfam04327
697281004771	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
697281004772	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
697281004773	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
697281004774	active site
697281004775	NTP binding site [chemical binding]; other site
697281004776	metal binding triad [ion binding]; metal-binding site
697281004777	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
697281004778	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
697281004779	Zn2+ binding site [ion binding]; other site
697281004780	Mg2+ binding site [ion binding]; other site
697281004781	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
697281004782	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
697281004783	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
697281004784	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281004785	FeS/SAM binding site; other site
697281004786	hypothetical protein; Provisional; Region: PRK03881
697281004787	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
697281004788	AMMECR1; Region: AMMECR1; pfam01871
697281004789	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
697281004790	homopentamer interface [polypeptide binding]; other site
697281004791	active site
697281004792	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
697281004793	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
697281004794	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
697281004795	dimerization interface [polypeptide binding]; other site
697281004796	active site
697281004797	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
697281004798	Lumazine binding domain; Region: Lum_binding; pfam00677
697281004799	Lumazine binding domain; Region: Lum_binding; pfam00677
697281004800	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
697281004801	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
697281004802	catalytic motif [active]
697281004803	Zn binding site [ion binding]; other site
697281004804	RibD C-terminal domain; Region: RibD_C; cl17279
697281004805	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
697281004806	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
697281004807	substrate binding site; other site
697281004808	dimer interface; other site
697281004809	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
697281004810	homotrimer interaction site [polypeptide binding]; other site
697281004811	zinc binding site [ion binding]; other site
697281004812	CDP-binding sites; other site
697281004813	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
697281004814	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
697281004815	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
697281004816	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
697281004817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281004818	dimer interface [polypeptide binding]; other site
697281004819	conserved gate region; other site
697281004820	putative PBP binding loops; other site
697281004821	ABC-ATPase subunit interface; other site
697281004822	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
697281004823	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
697281004824	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281004825	dimer interface [polypeptide binding]; other site
697281004826	conserved gate region; other site
697281004827	putative PBP binding loops; other site
697281004828	ABC-ATPase subunit interface; other site
697281004829	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
697281004830	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
697281004831	Walker A/P-loop; other site
697281004832	ATP binding site [chemical binding]; other site
697281004833	Q-loop/lid; other site
697281004834	ABC transporter signature motif; other site
697281004835	Walker B; other site
697281004836	D-loop; other site
697281004837	H-loop/switch region; other site
697281004838	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
697281004839	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
697281004840	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
697281004841	Walker A/P-loop; other site
697281004842	ATP binding site [chemical binding]; other site
697281004843	Q-loop/lid; other site
697281004844	ABC transporter signature motif; other site
697281004845	Walker B; other site
697281004846	D-loop; other site
697281004847	H-loop/switch region; other site
697281004848	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
697281004849	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
697281004850	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
697281004851	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
697281004852	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
697281004853	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
697281004854	Walker A/P-loop; other site
697281004855	ATP binding site [chemical binding]; other site
697281004856	Q-loop/lid; other site
697281004857	ABC transporter signature motif; other site
697281004858	Walker B; other site
697281004859	D-loop; other site
697281004860	H-loop/switch region; other site
697281004861	Abhydrolase family; Region: Abhydrolase_7; pfam12715
697281004862	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281004863	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
697281004864	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
697281004865	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281004866	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281004867	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281004868	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281004869	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
697281004870	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
697281004871	metal ion-dependent adhesion site (MIDAS); other site
697281004872	CARDB; Region: CARDB; pfam07705
697281004873	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
697281004874	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
697281004875	metal ion-dependent adhesion site (MIDAS); other site
697281004876	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
697281004877	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
697281004878	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
697281004879	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
697281004880	Protein of unknown function DUF58; Region: DUF58; pfam01882
697281004881	MoxR-like ATPases [General function prediction only]; Region: COG0714
697281004882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281004883	Walker A motif; other site
697281004884	ATP binding site [chemical binding]; other site
697281004885	Walker B motif; other site
697281004886	arginine finger; other site
697281004887	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
697281004888	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
697281004889	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
697281004890	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
697281004891	Walker A/P-loop; other site
697281004892	ATP binding site [chemical binding]; other site
697281004893	Q-loop/lid; other site
697281004894	ABC transporter signature motif; other site
697281004895	Walker B; other site
697281004896	D-loop; other site
697281004897	H-loop/switch region; other site
697281004898	Protein of unknown function (DUF458); Region: DUF458; pfam04308
697281004899	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
697281004900	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281004901	non-specific DNA binding site [nucleotide binding]; other site
697281004902	salt bridge; other site
697281004903	sequence-specific DNA binding site [nucleotide binding]; other site
697281004904	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
697281004905	acetylornithine aminotransferase; Provisional; Region: PRK02627
697281004906	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
697281004907	inhibitor-cofactor binding pocket; inhibition site
697281004908	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281004909	catalytic residue [active]
697281004910	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
697281004911	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
697281004912	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
697281004913	catalytic site [active]
697281004914	subunit interface [polypeptide binding]; other site
697281004915	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
697281004916	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
697281004917	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
697281004918	protein binding site [polypeptide binding]; other site
697281004919	CTP synthetase; Validated; Region: pyrG; PRK05380
697281004920	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
697281004921	Catalytic site [active]
697281004922	active site
697281004923	UTP binding site [chemical binding]; other site
697281004924	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
697281004925	active site
697281004926	putative oxyanion hole; other site
697281004927	catalytic triad [active]
697281004928	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
697281004929	PAS domain; Region: PAS; smart00091
697281004930	putative active site [active]
697281004931	heme pocket [chemical binding]; other site
697281004932	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
697281004933	dimer interface [polypeptide binding]; other site
697281004934	phosphorylation site [posttranslational modification]
697281004935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281004936	ATP binding site [chemical binding]; other site
697281004937	Mg2+ binding site [ion binding]; other site
697281004938	G-X-G motif; other site
697281004939	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
697281004940	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
697281004941	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
697281004942	tRNA binding surface [nucleotide binding]; other site
697281004943	DALR anticodon binding domain; Region: DALR_1; smart00836
697281004944	anticodon binding site; other site
697281004945	glutamate racemase; Provisional; Region: PRK00865
697281004946	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
697281004947	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
697281004948	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
697281004949	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
697281004950	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
697281004951	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
697281004952	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
697281004953	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
697281004954	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
697281004955	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
697281004956	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
697281004957	ligand binding site; other site
697281004958	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
697281004959	NeuB family; Region: NeuB; pfam03102
697281004960	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
697281004961	NeuB binding interface [polypeptide binding]; other site
697281004962	putative substrate binding site [chemical binding]; other site
697281004963	HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7
697281004964	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
697281004965	motif II; other site
697281004966	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
697281004967	ATP-grasp domain; Region: ATP-grasp_4; cl17255
697281004968	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281004969	Radical SAM superfamily; Region: Radical_SAM; pfam04055
697281004970	FeS/SAM binding site; other site
697281004971	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
697281004972	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
697281004973	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
697281004974	inhibitor-cofactor binding pocket; inhibition site
697281004975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281004976	catalytic residue [active]
697281004977	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
697281004978	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
697281004979	NAD(P) binding site [chemical binding]; other site
697281004980	active site
697281004981	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
697281004982	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
697281004983	NAD(P) binding site [chemical binding]; other site
697281004984	homodimer interface [polypeptide binding]; other site
697281004985	substrate binding site [chemical binding]; other site
697281004986	active site
697281004987	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
697281004988	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
697281004989	FlaG protein; Region: FlaG; pfam03646
697281004990	flagellin; Provisional; Region: PRK12804
697281004991	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
697281004992	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
697281004993	flagellin; Provisional; Region: PRK12804
697281004994	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
697281004995	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
697281004996	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
697281004997	sporulation sigma factor SigG; Reviewed; Region: PRK08215
697281004998	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281004999	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
697281005000	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281005001	DNA binding residues [nucleotide binding]
697281005002	sporulation sigma factor SigE; Reviewed; Region: PRK08301
697281005003	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281005004	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281005005	DNA binding residues [nucleotide binding]
697281005006	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
697281005007	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
697281005008	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
697281005009	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
697281005010	active site
697281005011	metal binding site [ion binding]; metal-binding site
697281005012	cell division protein FtsZ; Validated; Region: PRK09330
697281005013	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
697281005014	nucleotide binding site [chemical binding]; other site
697281005015	SulA interaction site; other site
697281005016	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
697281005017	Cell division protein FtsA; Region: FtsA; smart00842
697281005018	Cell division protein FtsA; Region: FtsA; pfam14450
697281005019	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
697281005020	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
697281005021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
697281005022	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
697281005023	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
697281005024	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
697281005025	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
697281005026	hinge; other site
697281005027	active site
697281005028	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
697281005029	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
697281005030	active site
697281005031	homodimer interface [polypeptide binding]; other site
697281005032	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
697281005033	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
697281005034	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
697281005035	NAD binding site [chemical binding]; other site
697281005036	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
697281005037	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
697281005038	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
697281005039	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
697281005040	Mg++ binding site [ion binding]; other site
697281005041	putative catalytic motif [active]
697281005042	putative substrate binding site [chemical binding]; other site
697281005043	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
697281005044	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
697281005045	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
697281005046	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
697281005047	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
697281005048	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
697281005049	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
697281005050	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
697281005051	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
697281005052	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
697281005053	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
697281005054	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
697281005055	Cell division protein FtsL; Region: FtsL; cl11433
697281005056	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
697281005057	MraW methylase family; Region: Methyltransf_5; cl17771
697281005058	cell division protein MraZ; Reviewed; Region: PRK00326
697281005059	MraZ protein; Region: MraZ; pfam02381
697281005060	MraZ protein; Region: MraZ; pfam02381
697281005061	cytidylate kinase; Provisional; Region: cmk; PRK00023
697281005062	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
697281005063	CMP-binding site; other site
697281005064	The sites determining sugar specificity; other site
697281005065	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
697281005066	homotrimer interaction site [polypeptide binding]; other site
697281005067	active site
697281005068	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
697281005069	hexamer interface [polypeptide binding]; other site
697281005070	RNA binding site [nucleotide binding]; other site
697281005071	Histidine-zinc binding site [chemical binding]; other site
697281005072	Bacterial Ig-like domain 2; Region: BID_2; smart00635
697281005073	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
697281005074	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281005075	Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247
697281005076	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281005077	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281005078	Helix-turn-helix domain; Region: HTH_17; pfam12728
697281005079	Tetratricopeptide repeat; Region: TPR_12; pfam13424
697281005080	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
697281005081	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
697281005082	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
697281005083	Walker A/P-loop; other site
697281005084	ATP binding site [chemical binding]; other site
697281005085	Q-loop/lid; other site
697281005086	ABC transporter signature motif; other site
697281005087	Walker B; other site
697281005088	D-loop; other site
697281005089	H-loop/switch region; other site
697281005090	5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231
697281005091	CopC domain; Region: CopC; cl01012
697281005092	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
697281005093	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
697281005094	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
697281005095	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
697281005096	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
697281005097	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
697281005098	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
697281005099	purine monophosphate binding site [chemical binding]; other site
697281005100	dimer interface [polypeptide binding]; other site
697281005101	putative catalytic residues [active]
697281005102	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
697281005103	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
697281005104	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
697281005105	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
697281005106	active site
697281005107	substrate binding site [chemical binding]; other site
697281005108	cosubstrate binding site; other site
697281005109	catalytic site [active]
697281005110	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
697281005111	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
697281005112	dimerization interface [polypeptide binding]; other site
697281005113	putative ATP binding site [chemical binding]; other site
697281005114	amidophosphoribosyltransferase; Provisional; Region: PRK05793
697281005115	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
697281005116	active site
697281005117	tetramer interface [polypeptide binding]; other site
697281005118	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
697281005119	active site
697281005120	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
697281005121	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
697281005122	dimerization interface [polypeptide binding]; other site
697281005123	ATP binding site [chemical binding]; other site
697281005124	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
697281005125	dimerization interface [polypeptide binding]; other site
697281005126	ATP binding site [chemical binding]; other site
697281005127	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
697281005128	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
697281005129	putative active site [active]
697281005130	catalytic triad [active]
697281005131	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
697281005132	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
697281005133	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
697281005134	ATP binding site [chemical binding]; other site
697281005135	active site
697281005136	substrate binding site [chemical binding]; other site
697281005137	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
697281005138	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
697281005139	GMP synthase; Reviewed; Region: guaA; PRK00074
697281005140	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
697281005141	AMP/PPi binding site [chemical binding]; other site
697281005142	candidate oxyanion hole; other site
697281005143	catalytic triad [active]
697281005144	potential glutamine specificity residues [chemical binding]; other site
697281005145	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
697281005146	ATP Binding subdomain [chemical binding]; other site
697281005147	Ligand Binding sites [chemical binding]; other site
697281005148	Dimerization subdomain; other site
697281005149	Protein of unknown function DUF111; Region: DUF111; pfam01969
697281005150	Septum formation topological specificity factor MinE; Region: MinE; cl00538
697281005151	septum site-determining protein MinD; Region: minD_bact; TIGR01968
697281005152	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
697281005153	Switch I; other site
697281005154	Switch II; other site
697281005155	septum formation inhibitor; Reviewed; Region: minC; PRK00513
697281005156	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
697281005157	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
697281005158	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
697281005159	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
697281005160	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
697281005161	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
697281005162	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
697281005163	rod shape-determining protein MreC; Provisional; Region: PRK13922
697281005164	basic region leucin zipper; Region: BRLZ; smart00338
697281005165	rod shape-determining protein MreC; Region: MreC; pfam04085
697281005166	rod shape-determining protein MreB; Provisional; Region: PRK13927
697281005167	MreB and similar proteins; Region: MreB_like; cd10225
697281005168	nucleotide binding site [chemical binding]; other site
697281005169	Mg binding site [ion binding]; other site
697281005170	putative protofilament interaction site [polypeptide binding]; other site
697281005171	RodZ interaction site [polypeptide binding]; other site
697281005172	hypothetical protein; Reviewed; Region: PRK00024
697281005173	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
697281005174	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
697281005175	MPN+ (JAMM) motif; other site
697281005176	Zinc-binding site [ion binding]; other site
697281005177	Maf-like protein; Reviewed; Region: PRK00078
697281005178	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
697281005179	active site
697281005180	dimer interface [polypeptide binding]; other site
697281005181	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
697281005182	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
697281005183	dimer interface [polypeptide binding]; other site
697281005184	putative anticodon binding site; other site
697281005185	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
697281005186	motif 1; other site
697281005187	active site
697281005188	motif 2; other site
697281005189	motif 3; other site
697281005190	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
697281005191	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
697281005192	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
697281005193	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
697281005194	NAD(P) binding pocket [chemical binding]; other site
697281005195	Helix-turn-helix domain; Region: HTH_31; pfam13560
697281005196	salt bridge; other site
697281005197	sequence-specific DNA binding site [nucleotide binding]; other site
697281005198	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
697281005199	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
697281005200	FMN binding site [chemical binding]; other site
697281005201	active site
697281005202	catalytic residues [active]
697281005203	substrate binding site [chemical binding]; other site
697281005204	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
697281005205	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
697281005206	active site
697281005207	stage II sporulation protein P; Region: spore_II_P; TIGR02867
697281005208	germination protease; Provisional; Region: PRK12362
697281005209	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
697281005210	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
697281005211	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
697281005212	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
697281005213	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
697281005214	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
697281005215	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
697281005216	LytB protein; Region: LYTB; cl00507
697281005217	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
697281005218	RNA binding site [nucleotide binding]; other site
697281005219	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
697281005220	RNA binding site [nucleotide binding]; other site
697281005221	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
697281005222	RNA binding site [nucleotide binding]; other site
697281005223	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
697281005224	RNA binding site [nucleotide binding]; other site
697281005225	domain interface; other site
697281005226	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
697281005227	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
697281005228	putative substrate binding site [chemical binding]; other site
697281005229	putative ATP binding site [chemical binding]; other site
697281005230	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
697281005231	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
697281005232	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
697281005233	dimer interface [polypeptide binding]; other site
697281005234	active site
697281005235	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
697281005236	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
697281005237	intersubunit interface [polypeptide binding]; other site
697281005238	active site
697281005239	zinc binding site [ion binding]; other site
697281005240	Na+ binding site [ion binding]; other site
697281005241	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
697281005242	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
697281005243	putative acyl-acceptor binding pocket; other site
697281005244	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
697281005245	Domain of unknown function (DUF377); Region: DUF377; pfam04041
697281005246	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
697281005247	active site
697281005248	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
697281005249	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
697281005250	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
697281005251	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
697281005252	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
697281005253	HlyD family secretion protein; Region: HlyD_3; pfam13437
697281005254	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
697281005255	N- and C-terminal domain interface [polypeptide binding]; other site
697281005256	D-xylulose kinase; Region: XylB; TIGR01312
697281005257	active site
697281005258	MgATP binding site [chemical binding]; other site
697281005259	catalytic site [active]
697281005260	metal binding site [ion binding]; metal-binding site
697281005261	xylulose binding site [chemical binding]; other site
697281005262	homodimer interface [polypeptide binding]; other site
697281005263	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
697281005264	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
697281005265	Metal-binding active site; metal-binding site
697281005266	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281005267	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005268	dimer interface [polypeptide binding]; other site
697281005269	ABC-ATPase subunit interface; other site
697281005270	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281005271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005272	dimer interface [polypeptide binding]; other site
697281005273	conserved gate region; other site
697281005274	ABC-ATPase subunit interface; other site
697281005275	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281005276	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281005277	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281005278	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281005279	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
697281005280	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
697281005281	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
697281005282	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
697281005283	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
697281005284	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
697281005285	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
697281005286	HIGH motif; other site
697281005287	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
697281005288	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
697281005289	active site
697281005290	KMSKS motif; other site
697281005291	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
697281005292	tRNA binding surface [nucleotide binding]; other site
697281005293	anticodon binding site; other site
697281005294	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
697281005295	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
697281005296	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
697281005297	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
697281005298	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
697281005299	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
697281005300	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
697281005301	5S rRNA interface [nucleotide binding]; other site
697281005302	CTC domain interface [polypeptide binding]; other site
697281005303	L16 interface [polypeptide binding]; other site
697281005304	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
697281005305	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
697281005306	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
697281005307	Ligand Binding Site [chemical binding]; other site
697281005308	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
697281005309	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
697281005310	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
697281005311	catalytic residue [active]
697281005312	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
697281005313	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
697281005314	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
697281005315	propionate/acetate kinase; Provisional; Region: PRK12379
697281005316	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
697281005317	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
697281005318	Uncharacterized membrane protein [Function unknown]; Region: COG3949
697281005319	Malic enzyme, N-terminal domain; Region: malic; pfam00390
697281005320	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
697281005321	putative NAD(P) binding site [chemical binding]; other site
697281005322	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
697281005323	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
697281005324	Zn2+ binding site [ion binding]; other site
697281005325	Mg2+ binding site [ion binding]; other site
697281005326	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
697281005327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281005328	active site
697281005329	phosphorylation site [posttranslational modification]
697281005330	intermolecular recognition site; other site
697281005331	dimerization interface [polypeptide binding]; other site
697281005332	ANTAR domain; Region: ANTAR; pfam03861
697281005333	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
697281005334	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
697281005335	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
697281005336	Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981
697281005337	putative subunit interface; other site
697281005338	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
697281005339	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
697281005340	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
697281005341	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
697281005342	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
697281005343	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
697281005344	active site
697281005345	FMN binding site [chemical binding]; other site
697281005346	substrate binding site [chemical binding]; other site
697281005347	3Fe-4S cluster binding site [ion binding]; other site
697281005348	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
697281005349	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
697281005350	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
697281005351	putative active site [active]
697281005352	dihydrodipicolinate reductase; Provisional; Region: PRK00048
697281005353	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
697281005354	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
697281005355	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
697281005356	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
697281005357	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
697281005358	HIGH motif; other site
697281005359	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
697281005360	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
697281005361	active site
697281005362	KMSKS motif; other site
697281005363	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
697281005364	tRNA binding surface [nucleotide binding]; other site
697281005365	Oligomerisation domain; Region: Oligomerisation; pfam02410
697281005366	Spore germination protein; Region: Spore_permease; cl17796
697281005367	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
697281005368	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
697281005369	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
697281005370	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
697281005371	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
697281005372	nucleotide binding pocket [chemical binding]; other site
697281005373	K-X-D-G motif; other site
697281005374	catalytic site [active]
697281005375	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
697281005376	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
697281005377	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
697281005378	Dimer interface [polypeptide binding]; other site
697281005379	BRCT sequence motif; other site
697281005380	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
697281005381	Part of AAA domain; Region: AAA_19; pfam13245
697281005382	Family description; Region: UvrD_C_2; pfam13538
697281005383	Trp repressor protein; Region: Trp_repressor; cl17266
697281005384	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
697281005385	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
697281005386	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
697281005387	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
697281005388	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
697281005389	PYR/PP interface [polypeptide binding]; other site
697281005390	dimer interface [polypeptide binding]; other site
697281005391	TPP binding site [chemical binding]; other site
697281005392	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
697281005393	transketolase; Reviewed; Region: PRK05899
697281005394	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
697281005395	TPP-binding site [chemical binding]; other site
697281005396	dimer interface [polypeptide binding]; other site
697281005397	Uncharacterized conserved protein [Function unknown]; Region: COG1284
697281005398	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
697281005399	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
697281005400	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
697281005401	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
697281005402	MutS domain III; Region: MutS_III; pfam05192
697281005403	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
697281005404	Walker A/P-loop; other site
697281005405	ATP binding site [chemical binding]; other site
697281005406	Q-loop/lid; other site
697281005407	ABC transporter signature motif; other site
697281005408	Walker B; other site
697281005409	D-loop; other site
697281005410	H-loop/switch region; other site
697281005411	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
697281005412	Smr domain; Region: Smr; pfam01713
697281005413	Cell division protein ZapA; Region: ZapA; pfam05164
697281005414	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
697281005415	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
697281005416	putative tRNA-binding site [nucleotide binding]; other site
697281005417	B3/4 domain; Region: B3_4; pfam03483
697281005418	tRNA synthetase B5 domain; Region: B5; smart00874
697281005419	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
697281005420	dimer interface [polypeptide binding]; other site
697281005421	motif 1; other site
697281005422	motif 3; other site
697281005423	motif 2; other site
697281005424	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
697281005425	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
697281005426	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
697281005427	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
697281005428	dimer interface [polypeptide binding]; other site
697281005429	motif 1; other site
697281005430	active site
697281005431	motif 2; other site
697281005432	motif 3; other site
697281005433	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
697281005434	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
697281005435	putative active site [active]
697281005436	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
697281005437	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
697281005438	active site
697281005439	metal binding site [ion binding]; metal-binding site
697281005440	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281005441	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281005442	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281005443	PrcB C-terminal; Region: PrcB_C; pfam14343
697281005444	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
697281005445	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
697281005446	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
697281005447	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
697281005448	TrkA-N domain; Region: TrkA_N; pfam02254
697281005449	TrkA-C domain; Region: TrkA_C; pfam02080
697281005450	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
697281005451	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
697281005452	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
697281005453	Haemolysin XhlA; Region: XhlA; pfam10779
697281005454	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
697281005455	elongation factor G; Reviewed; Region: PRK12740
697281005456	G1 box; other site
697281005457	putative GEF interaction site [polypeptide binding]; other site
697281005458	GTP/Mg2+ binding site [chemical binding]; other site
697281005459	Switch I region; other site
697281005460	G2 box; other site
697281005461	G3 box; other site
697281005462	Switch II region; other site
697281005463	G4 box; other site
697281005464	G5 box; other site
697281005465	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
697281005466	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
697281005467	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
697281005468	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
697281005469	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
697281005470	Tetramer interface [polypeptide binding]; other site
697281005471	active site
697281005472	FMN-binding site [chemical binding]; other site
697281005473	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
697281005474	active site
697281005475	dimer interface [polypeptide binding]; other site
697281005476	metal binding site [ion binding]; metal-binding site
697281005477	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
697281005478	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
697281005479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281005480	homodimer interface [polypeptide binding]; other site
697281005481	catalytic residue [active]
697281005482	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
697281005483	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
697281005484	prephenate dehydrogenase; Validated; Region: PRK06545
697281005485	prephenate dehydrogenase; Validated; Region: PRK08507
697281005486	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
697281005487	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
697281005488	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
697281005489	hinge; other site
697281005490	active site
697281005491	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
697281005492	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281005493	non-specific DNA binding site [nucleotide binding]; other site
697281005494	salt bridge; other site
697281005495	sequence-specific DNA binding site [nucleotide binding]; other site
697281005496	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
697281005497	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
697281005498	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
697281005499	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
697281005500	excinuclease ABC subunit B; Provisional; Region: PRK05298
697281005501	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
697281005502	ATP binding site [chemical binding]; other site
697281005503	putative Mg++ binding site [ion binding]; other site
697281005504	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
697281005505	nucleotide binding region [chemical binding]; other site
697281005506	ATP-binding site [chemical binding]; other site
697281005507	Ultra-violet resistance protein B; Region: UvrB; pfam12344
697281005508	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
697281005509	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
697281005510	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
697281005511	C-terminal peptidase (prc); Region: prc; TIGR00225
697281005512	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
697281005513	protein binding site [polypeptide binding]; other site
697281005514	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
697281005515	Catalytic dyad [active]
697281005516	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
697281005517	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
697281005518	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
697281005519	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
697281005520	Protein of unknown function DUF58; Region: DUF58; pfam01882
697281005521	MoxR-like ATPases [General function prediction only]; Region: COG0714
697281005522	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281005523	ATP binding site [chemical binding]; other site
697281005524	Walker A motif; other site
697281005525	Walker B motif; other site
697281005526	arginine finger; other site
697281005527	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
697281005528	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
697281005529	active site
697281005530	catalytic residues [active]
697281005531	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
697281005532	NodB motif; other site
697281005533	putative active site [active]
697281005534	putative catalytic site [active]
697281005535	Zn binding site [ion binding]; other site
697281005536	oxidoreductase; Provisional; Region: PRK10015
697281005537	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
697281005538	BioY family; Region: BioY; pfam02632
697281005539	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281005540	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
697281005541	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
697281005542	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
697281005543	CoA binding domain; Region: CoA_binding_2; pfam13380
697281005544	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
697281005545	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
697281005546	NAD(P) binding site [chemical binding]; other site
697281005547	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
697281005548	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
697281005549	nucleotide binding site [chemical binding]; other site
697281005550	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
697281005551	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
697281005552	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
697281005553	substrate binding site [chemical binding]; other site
697281005554	hexamer interface [polypeptide binding]; other site
697281005555	metal binding site [ion binding]; metal-binding site
697281005556	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281005557	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281005558	DNA binding site [nucleotide binding]
697281005559	domain linker motif; other site
697281005560	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281005561	dimerization interface [polypeptide binding]; other site
697281005562	ligand binding site [chemical binding]; other site
697281005563	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
697281005564	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
697281005565	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
697281005566	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
697281005567	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281005568	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
697281005569	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281005570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005571	dimer interface [polypeptide binding]; other site
697281005572	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
697281005573	ABC-ATPase subunit interface; other site
697281005574	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281005575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005576	dimer interface [polypeptide binding]; other site
697281005577	conserved gate region; other site
697281005578	putative PBP binding loops; other site
697281005579	ABC-ATPase subunit interface; other site
697281005580	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281005581	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281005582	Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551
697281005583	active site
697281005584	catalytic site [active]
697281005585	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
697281005586	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
697281005587	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
697281005588	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
697281005589	inhibitor site; inhibition site
697281005590	active site
697281005591	dimer interface [polypeptide binding]; other site
697281005592	catalytic residue [active]
697281005593	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
697281005594	Stage II sporulation protein; Region: SpoIID; pfam08486
697281005595	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
697281005596	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
697281005597	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
697281005598	hinge; other site
697281005599	active site
697281005600	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
697281005601	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
697281005602	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
697281005603	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
697281005604	active site
697281005605	Domain of unknown function (DUF377); Region: DUF377; pfam04041
697281005606	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
697281005607	active site
697281005608	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
697281005609	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
697281005610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
697281005611	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
697281005612	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
697281005613	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
697281005614	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
697281005615	Coenzyme A binding pocket [chemical binding]; other site
697281005616	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281005617	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281005618	Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802
697281005619	putative active site [active]
697281005620	YdjC motif; other site
697281005621	Mg binding site [ion binding]; other site
697281005622	homodimer interface [polypeptide binding]; other site
697281005623	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
697281005624	Response regulator receiver domain; Region: Response_reg; pfam00072
697281005625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281005626	active site
697281005627	phosphorylation site [posttranslational modification]
697281005628	intermolecular recognition site; other site
697281005629	dimerization interface [polypeptide binding]; other site
697281005630	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281005631	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281005632	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281005633	HAMP domain; Region: HAMP; pfam00672
697281005634	dimerization interface [polypeptide binding]; other site
697281005635	Histidine kinase; Region: His_kinase; pfam06580
697281005636	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
697281005637	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281005638	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281005639	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281005640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005641	dimer interface [polypeptide binding]; other site
697281005642	conserved gate region; other site
697281005643	putative PBP binding loops; other site
697281005644	ABC-ATPase subunit interface; other site
697281005645	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281005646	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005647	ABC-ATPase subunit interface; other site
697281005648	Telokin-like protein-20 (TLP-20) domain; a baculovirus protein that shares some antigenic similarities to the smooth muscle protein telokin, a kinase-related protein; Region: TLP-20; cl17542
697281005649	NHL repeat; Region: NHL; pfam01436
697281005650	TPR repeat; Region: TPR_11; pfam13414
697281005651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
697281005652	TPR motif; other site
697281005653	Yip1 domain; Region: Yip1; pfam04893
697281005654	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281005655	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005656	dimer interface [polypeptide binding]; other site
697281005657	conserved gate region; other site
697281005658	ABC-ATPase subunit interface; other site
697281005659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005660	dimer interface [polypeptide binding]; other site
697281005661	conserved gate region; other site
697281005662	putative PBP binding loops; other site
697281005663	ABC-ATPase subunit interface; other site
697281005664	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
697281005665	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
697281005666	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281005667	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281005668	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
697281005669	FtsX-like permease family; Region: FtsX; pfam02687
697281005670	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
697281005671	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
697281005672	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
697281005673	Interdomain contacts; other site
697281005674	Cytokine receptor motif; other site
697281005675	Right handed beta helix region; Region: Beta_helix; pfam13229
697281005676	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
697281005677	intersubunit interface [polypeptide binding]; other site
697281005678	active site
697281005679	catalytic residue [active]
697281005680	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281005681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005682	dimer interface [polypeptide binding]; other site
697281005683	ABC-ATPase subunit interface; other site
697281005684	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281005685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005686	dimer interface [polypeptide binding]; other site
697281005687	conserved gate region; other site
697281005688	ABC-ATPase subunit interface; other site
697281005689	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281005690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281005691	active site
697281005692	phosphorylation site [posttranslational modification]
697281005693	intermolecular recognition site; other site
697281005694	dimerization interface [polypeptide binding]; other site
697281005695	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281005696	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281005697	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281005698	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
697281005699	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281005700	dimerization interface [polypeptide binding]; other site
697281005701	Histidine kinase; Region: His_kinase; pfam06580
697281005702	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
697281005703	Mg2+ binding site [ion binding]; other site
697281005704	G-X-G motif; other site
697281005705	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
697281005706	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
697281005707	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
697281005708	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
697281005709	putative active site [active]
697281005710	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
697281005711	Probable transposase; Region: OrfB_IS605; pfam01385
697281005712	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
697281005713	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
697281005714	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
697281005715	metal binding site [ion binding]; metal-binding site
697281005716	substrate binding pocket [chemical binding]; other site
697281005717	Cupin domain; Region: Cupin_2; pfam07883
697281005718	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281005719	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
697281005720	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
697281005721	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
697281005722	Sulfatase; Region: Sulfatase; cl17466
697281005723	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
697281005724	Sulfatase; Region: Sulfatase; cl17466
697281005725	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
697281005726	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
697281005727	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
697281005728	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281005729	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281005730	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281005731	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281005732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005733	dimer interface [polypeptide binding]; other site
697281005734	conserved gate region; other site
697281005735	putative PBP binding loops; other site
697281005736	ABC-ATPase subunit interface; other site
697281005737	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281005738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281005739	dimer interface [polypeptide binding]; other site
697281005740	conserved gate region; other site
697281005741	putative PBP binding loops; other site
697281005742	ABC-ATPase subunit interface; other site
697281005743	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281005744	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281005745	fumarate hydratase; Provisional; Region: PRK06246
697281005746	Fumarase C-terminus; Region: Fumerase_C; pfam05683
697281005747	S-adenosylmethionine synthetase; Validated; Region: PRK05250
697281005748	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
697281005749	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
697281005750	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
697281005751	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
697281005752	FAD binding domain; Region: FAD_binding_4; pfam01565
697281005753	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
697281005754	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
697281005755	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
697281005756	nucleotide binding site [chemical binding]; other site
697281005757	putative hydrolase; Validated; Region: PRK09248
697281005758	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
697281005759	active site
697281005760	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
697281005761	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
697281005762	dimer interface [polypeptide binding]; other site
697281005763	active site
697281005764	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
697281005765	dimer interface [polypeptide binding]; other site
697281005766	active site
697281005767	HPr kinase/phosphorylase; Provisional; Region: PRK05428
697281005768	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
697281005769	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
697281005770	Hpr binding site; other site
697281005771	active site
697281005772	homohexamer subunit interaction site [polypeptide binding]; other site
697281005773	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
697281005774	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
697281005775	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
697281005776	metal binding site [ion binding]; metal-binding site
697281005777	active site
697281005778	I-site; other site
697281005779	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
697281005780	Zn2+ binding site [ion binding]; other site
697281005781	Mg2+ binding site [ion binding]; other site
697281005782	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
697281005783	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
697281005784	GIY-YIG motif/motif A; other site
697281005785	active site
697281005786	catalytic site [active]
697281005787	putative DNA binding site [nucleotide binding]; other site
697281005788	metal binding site [ion binding]; metal-binding site
697281005789	UvrB/uvrC motif; Region: UVR; pfam02151
697281005790	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
697281005791	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
697281005792	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
697281005793	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
697281005794	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
697281005795	TPP-binding site [chemical binding]; other site
697281005796	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
697281005797	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
697281005798	dimer interface [polypeptide binding]; other site
697281005799	PYR/PP interface [polypeptide binding]; other site
697281005800	TPP binding site [chemical binding]; other site
697281005801	substrate binding site [chemical binding]; other site
697281005802	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
697281005803	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
697281005804	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
697281005805	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
697281005806	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
697281005807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
697281005808	YbbR-like protein; Region: YbbR; pfam07949
697281005809	TIGR00159 family protein; Region: TIGR00159
697281005810	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
697281005811	Heme NO binding; Region: HNOB; pfam07700
697281005812	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
697281005813	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
697281005814	dimer interface [polypeptide binding]; other site
697281005815	putative CheW interface [polypeptide binding]; other site
697281005816	PemK-like protein; Region: PemK; pfam02452
697281005817	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
697281005818	Uncharacterized conserved protein [Function unknown]; Region: COG0062
697281005819	putative carbohydrate kinase; Provisional; Region: PRK10565
697281005820	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
697281005821	putative substrate binding site [chemical binding]; other site
697281005822	putative ATP binding site [chemical binding]; other site
697281005823	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
697281005824	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
697281005825	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
697281005826	SmpB-tmRNA interface; other site
697281005827	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
697281005828	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
697281005829	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
697281005830	GTP-binding protein Der; Reviewed; Region: PRK00093
697281005831	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
697281005832	G1 box; other site
697281005833	GTP/Mg2+ binding site [chemical binding]; other site
697281005834	Switch I region; other site
697281005835	G2 box; other site
697281005836	Switch II region; other site
697281005837	G3 box; other site
697281005838	G4 box; other site
697281005839	G5 box; other site
697281005840	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
697281005841	G1 box; other site
697281005842	GTP/Mg2+ binding site [chemical binding]; other site
697281005843	Switch I region; other site
697281005844	G2 box; other site
697281005845	G3 box; other site
697281005846	Switch II region; other site
697281005847	G4 box; other site
697281005848	G5 box; other site
697281005849	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
697281005850	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
697281005851	Protein of unknown function (DUF512); Region: DUF512; pfam04459
697281005852	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
697281005853	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
697281005854	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
697281005855	metal binding site 2 [ion binding]; metal-binding site
697281005856	putative DNA binding helix; other site
697281005857	metal binding site 1 [ion binding]; metal-binding site
697281005858	dimer interface [polypeptide binding]; other site
697281005859	structural Zn2+ binding site [ion binding]; other site
697281005860	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
697281005861	active site
697281005862	catalytic triad [active]
697281005863	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
697281005864	active site
697281005865	6-phosphofructokinase; Provisional; Region: PRK03202
697281005866	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
697281005867	active site
697281005868	ADP/pyrophosphate binding site [chemical binding]; other site
697281005869	dimerization interface [polypeptide binding]; other site
697281005870	allosteric effector site; other site
697281005871	fructose-1,6-bisphosphate binding site; other site
697281005872	transcription attenuation protein MtrB; Provisional; Region: PRK13251
697281005873	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
697281005874	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
697281005875	active site
697281005876	PHP Thumb interface [polypeptide binding]; other site
697281005877	metal binding site [ion binding]; metal-binding site
697281005878	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
697281005879	generic binding surface I; other site
697281005880	generic binding surface II; other site
697281005881	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
697281005882	dimerization domain swap beta strand [polypeptide binding]; other site
697281005883	regulatory protein interface [polypeptide binding]; other site
697281005884	active site
697281005885	regulatory phosphorylation site [posttranslational modification]; other site
697281005886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
697281005887	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
697281005888	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
697281005889	shikimate kinase; Provisional; Region: PRK13947
697281005890	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
697281005891	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
697281005892	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
697281005893	intersubunit interface [polypeptide binding]; other site
697281005894	active site
697281005895	Zn2+ binding site [ion binding]; other site
697281005896	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
697281005897	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
697281005898	ABC1 family; Region: ABC1; pfam03109
697281005899	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
697281005900	active site
697281005901	ATP binding site [chemical binding]; other site
697281005902	Uncharacterized conserved protein [Function unknown]; Region: COG3937
697281005903	ribonuclease R; Region: RNase_R; TIGR02063
697281005904	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
697281005905	RNA binding site [nucleotide binding]; other site
697281005906	RNB domain; Region: RNB; pfam00773
697281005907	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
697281005908	RNA binding site [nucleotide binding]; other site
697281005909	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
697281005910	Preprotein translocase SecG subunit; Region: SecG; pfam03840
697281005911	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
697281005912	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
697281005913	putative substrate binding site [chemical binding]; other site
697281005914	putative ATP binding site [chemical binding]; other site
697281005915	LemA family; Region: LemA; cl00742
697281005916	Repair protein; Region: Repair_PSII; pfam04536
697281005917	Radical SAM superfamily; Region: Radical_SAM; pfam04055
697281005918	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281005919	FeS/SAM binding site; other site
697281005920	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12667
697281005921	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
697281005922	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
697281005923	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
697281005924	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
697281005925	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
697281005926	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
697281005927	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
697281005928	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
697281005929	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
697281005930	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
697281005931	23S rRNA interface [nucleotide binding]; other site
697281005932	L3 interface [polypeptide binding]; other site
697281005933	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
697281005934	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
697281005935	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
697281005936	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
697281005937	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
697281005938	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281005939	Walker A motif; other site
697281005940	ATP binding site [chemical binding]; other site
697281005941	Walker B motif; other site
697281005942	arginine finger; other site
697281005943	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
697281005944	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
697281005945	RuvA N terminal domain; Region: RuvA_N; pfam01330
697281005946	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
697281005947	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
697281005948	active site
697281005949	putative DNA-binding cleft [nucleotide binding]; other site
697281005950	dimer interface [polypeptide binding]; other site
697281005951	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
697281005952	argininosuccinate synthase; Provisional; Region: PRK13820
697281005953	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
697281005954	ANP binding site [chemical binding]; other site
697281005955	Substrate Binding Site II [chemical binding]; other site
697281005956	Substrate Binding Site I [chemical binding]; other site
697281005957	argininosuccinate lyase; Provisional; Region: PRK00855
697281005958	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
697281005959	active sites [active]
697281005960	tetramer interface [polypeptide binding]; other site
697281005961	DNA polymerase III PolC; Validated; Region: polC; PRK00448
697281005962	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
697281005963	generic binding surface II; other site
697281005964	generic binding surface I; other site
697281005965	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
697281005966	active site
697281005967	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
697281005968	active site
697281005969	catalytic site [active]
697281005970	substrate binding site [chemical binding]; other site
697281005971	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
697281005972	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
697281005973	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
697281005974	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
697281005975	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
697281005976	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
697281005977	active site
697281005978	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
697281005979	protein binding site [polypeptide binding]; other site
697281005980	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
697281005981	putative substrate binding region [chemical binding]; other site
697281005982	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
697281005983	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
697281005984	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
697281005985	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
697281005986	Domain of unknown function DUF20; Region: UPF0118; pfam01594
697281005987	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
697281005988	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
697281005989	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
697281005990	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
697281005991	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
697281005992	catalytic residue [active]
697281005993	putative FPP diphosphate  binding site; other site
697281005994	putative FPP binding hydrophobic cleft; other site
697281005995	dimer interface [polypeptide binding]; other site
697281005996	putative IPP diphosphate binding site; other site
697281005997	ribosome recycling factor; Reviewed; Region: frr; PRK00083
697281005998	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
697281005999	hinge region; other site
697281006000	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
697281006001	putative nucleotide binding site [chemical binding]; other site
697281006002	uridine monophosphate binding site [chemical binding]; other site
697281006003	homohexameric interface [polypeptide binding]; other site
697281006004	elongation factor Ts; Reviewed; Region: tsf; PRK12332
697281006005	UBA/TS-N domain; Region: UBA; pfam00627
697281006006	Elongation factor TS; Region: EF_TS; pfam00889
697281006007	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
697281006008	rRNA interaction site [nucleotide binding]; other site
697281006009	S8 interaction site; other site
697281006010	putative laminin-1 binding site; other site
697281006011	Membrane protein of unknown function; Region: DUF360; pfam04020
697281006012	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
697281006013	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
697281006014	GAF domain; Region: GAF_3; pfam13492
697281006015	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
697281006016	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
697281006017	metal binding site [ion binding]; metal-binding site
697281006018	active site
697281006019	I-site; other site
697281006020	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
697281006021	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
697281006022	minor groove reading motif; other site
697281006023	helix-hairpin-helix signature motif; other site
697281006024	substrate binding pocket [chemical binding]; other site
697281006025	active site
697281006026	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
697281006027	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
697281006028	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
697281006029	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
697281006030	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
697281006031	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
697281006032	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
697281006033	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
697281006034	putative homodimer interface [polypeptide binding]; other site
697281006035	Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848
697281006036	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
697281006037	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
697281006038	putative metal binding site; other site
697281006039	TPR repeat; Region: TPR_11; pfam13414
697281006040	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
697281006041	binding surface
697281006042	TPR motif; other site
697281006043	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
697281006044	TPR motif; other site
697281006045	binding surface
697281006046	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
697281006047	TPR motif; other site
697281006048	binding surface
697281006049	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
697281006050	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
697281006051	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
697281006052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281006053	ATP binding site [chemical binding]; other site
697281006054	Mg2+ binding site [ion binding]; other site
697281006055	G-X-G motif; other site
697281006056	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
697281006057	ATP binding site [chemical binding]; other site
697281006058	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
697281006059	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
697281006060	MutS domain I; Region: MutS_I; pfam01624
697281006061	MutS domain II; Region: MutS_II; pfam05188
697281006062	MutS domain III; Region: MutS_III; pfam05192
697281006063	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
697281006064	Walker A/P-loop; other site
697281006065	ATP binding site [chemical binding]; other site
697281006066	Q-loop/lid; other site
697281006067	ABC transporter signature motif; other site
697281006068	Walker B; other site
697281006069	D-loop; other site
697281006070	H-loop/switch region; other site
697281006071	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
697281006072	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
697281006073	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281006074	FeS/SAM binding site; other site
697281006075	TRAM domain; Region: TRAM; pfam01938
697281006076	Yqey-like protein; Region: YqeY; pfam09424
697281006077	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
697281006078	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
697281006079	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
697281006080	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
697281006081	active site
697281006082	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
697281006083	dimer interface [polypeptide binding]; other site
697281006084	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
697281006085	Ligand Binding Site [chemical binding]; other site
697281006086	Molecular Tunnel; other site
697281006087	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
697281006088	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
697281006089	ABC-ATPase subunit  interface; other site
697281006090	dimer interface [polypeptide binding]; other site
697281006091	putative PBP binding regions; other site
697281006092	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
697281006093	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
697281006094	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
697281006095	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
697281006096	metal binding site [ion binding]; metal-binding site
697281006097	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
697281006098	metal binding site 2 [ion binding]; metal-binding site
697281006099	putative DNA binding helix; other site
697281006100	metal binding site 1 [ion binding]; metal-binding site
697281006101	dimer interface [polypeptide binding]; other site
697281006102	structural Zn2+ binding site [ion binding]; other site
697281006103	Domain of unknown function (DUF348); Region: DUF348; pfam03990
697281006104	Domain of unknown function (DUF348); Region: DUF348; pfam03990
697281006105	Domain of unknown function (DUF348); Region: DUF348; pfam03990
697281006106	G5 domain; Region: G5; pfam07501
697281006107	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
697281006108	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
697281006109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
697281006110	S-adenosylmethionine binding site [chemical binding]; other site
697281006111	PDGLE domain; Region: PDGLE; pfam13190
697281006112	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
697281006113	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
697281006114	alpha-galactosidase; Provisional; Region: PRK15076
697281006115	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
697281006116	NAD binding site [chemical binding]; other site
697281006117	sugar binding site [chemical binding]; other site
697281006118	divalent metal binding site [ion binding]; other site
697281006119	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
697281006120	dimer interface [polypeptide binding]; other site
697281006121	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
697281006122	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281006123	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281006124	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281006125	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
697281006126	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
697281006127	metal-binding site [ion binding]
697281006128	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
697281006129	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
697281006130	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
697281006131	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
697281006132	active site
697281006133	FMN binding site [chemical binding]; other site
697281006134	substrate binding site [chemical binding]; other site
697281006135	putative catalytic residue [active]
697281006136	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
697281006137	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
697281006138	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
697281006139	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
697281006140	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281006141	catalytic residue [active]
697281006142	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
697281006143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006144	dimer interface [polypeptide binding]; other site
697281006145	conserved gate region; other site
697281006146	putative PBP binding loops; other site
697281006147	ABC-ATPase subunit interface; other site
697281006148	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
697281006149	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
697281006150	Walker A/P-loop; other site
697281006151	ATP binding site [chemical binding]; other site
697281006152	Q-loop/lid; other site
697281006153	ABC transporter signature motif; other site
697281006154	Walker B; other site
697281006155	D-loop; other site
697281006156	H-loop/switch region; other site
697281006157	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
697281006158	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
697281006159	substrate binding pocket [chemical binding]; other site
697281006160	chain length determination region; other site
697281006161	substrate-Mg2+ binding site; other site
697281006162	catalytic residues [active]
697281006163	aspartate-rich region 1; other site
697281006164	active site lid residues [active]
697281006165	aspartate-rich region 2; other site
697281006166	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
697281006167	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
697281006168	trimer interface [polypeptide binding]; other site
697281006169	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
697281006170	ApbE family; Region: ApbE; pfam02424
697281006171	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
697281006172	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
697281006173	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
697281006174	active site
697281006175	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
697281006176	catalytic tetrad [active]
697281006177	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
697281006178	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
697281006179	substrate binding site [chemical binding]; other site
697281006180	ATP binding site [chemical binding]; other site
697281006181	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
697281006182	S-adenosylmethionine binding site [chemical binding]; other site
697281006183	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
697281006184	Putative carbohydrate binding domain; Region: CBM_X; pfam06204
697281006185	Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_4; cd11751
697281006186	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281006187	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281006188	DNA binding site [nucleotide binding]
697281006189	domain linker motif; other site
697281006190	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281006191	dimerization interface [polypeptide binding]; other site
697281006192	ligand binding site [chemical binding]; other site
697281006193	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281006194	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281006195	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281006196	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281006197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006198	dimer interface [polypeptide binding]; other site
697281006199	conserved gate region; other site
697281006200	putative PBP binding loops; other site
697281006201	ABC-ATPase subunit interface; other site
697281006202	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281006203	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006204	dimer interface [polypeptide binding]; other site
697281006205	conserved gate region; other site
697281006206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
697281006207	ABC-ATPase subunit interface; other site
697281006208	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
697281006209	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
697281006210	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
697281006211	stage II sporulation protein P; Region: spore_II_P; TIGR02867
697281006212	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
697281006213	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
697281006214	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006215	dimer interface [polypeptide binding]; other site
697281006216	conserved gate region; other site
697281006217	putative PBP binding loops; other site
697281006218	ABC-ATPase subunit interface; other site
697281006219	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
697281006220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006221	dimer interface [polypeptide binding]; other site
697281006222	conserved gate region; other site
697281006223	ABC-ATPase subunit interface; other site
697281006224	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281006225	dimerization interface [polypeptide binding]; other site
697281006226	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
697281006227	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
697281006228	dimer interface [polypeptide binding]; other site
697281006229	putative CheW interface [polypeptide binding]; other site
697281006230	PBP superfamily domain; Region: PBP_like_2; cl17296
697281006231	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
697281006232	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
697281006233	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
697281006234	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
697281006235	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
697281006236	active site
697281006237	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
697281006238	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281006239	putative DNA binding site [nucleotide binding]; other site
697281006240	putative Zn2+ binding site [ion binding]; other site
697281006241	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
697281006242	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
697281006243	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
697281006244	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
697281006245	substrate binding site [chemical binding]; other site
697281006246	ATP binding site [chemical binding]; other site
697281006247	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
697281006248	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
697281006249	motif II; other site
697281006250	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
697281006251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
697281006252	putative substrate translocation pore; other site
697281006253	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
697281006254	glycogen branching enzyme; Provisional; Region: PRK12313
697281006255	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
697281006256	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
697281006257	active site
697281006258	catalytic site [active]
697281006259	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
697281006260	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
697281006261	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
697281006262	ligand binding site; other site
697281006263	oligomer interface; other site
697281006264	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
697281006265	dimer interface [polypeptide binding]; other site
697281006266	N-terminal domain interface [polypeptide binding]; other site
697281006267	sulfate 1 binding site; other site
697281006268	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
697281006269	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
697281006270	ligand binding site; other site
697281006271	oligomer interface; other site
697281006272	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
697281006273	dimer interface [polypeptide binding]; other site
697281006274	N-terminal domain interface [polypeptide binding]; other site
697281006275	sulfate 1 binding site; other site
697281006276	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
697281006277	homodimer interface [polypeptide binding]; other site
697281006278	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
697281006279	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
697281006280	active site
697281006281	homodimer interface [polypeptide binding]; other site
697281006282	catalytic site [active]
697281006283	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
697281006284	homodimer interface [polypeptide binding]; other site
697281006285	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
697281006286	active site pocket [active]
697281006287	glycogen synthase; Provisional; Region: glgA; PRK00654
697281006288	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
697281006289	ADP-binding pocket [chemical binding]; other site
697281006290	homodimer interface [polypeptide binding]; other site
697281006291	Uncharacterized conserved protein [Function unknown]; Region: COG0398
697281006292	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
697281006293	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
697281006294	glutamine binding [chemical binding]; other site
697281006295	catalytic triad [active]
697281006296	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
697281006297	dinuclear metal binding motif [ion binding]; other site
697281006298	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
697281006299	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
697281006300	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
697281006301	NAD(P) binding site [chemical binding]; other site
697281006302	active site
697281006303	Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229
697281006304	putative active site [active]
697281006305	Zn binding site [ion binding]; other site
697281006306	Uncharacterized conserved protein [Function unknown]; Region: COG1633
697281006307	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
697281006308	diiron binding motif [ion binding]; other site
697281006309	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
697281006310	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
697281006311	NAD binding site [chemical binding]; other site
697281006312	ligand binding site [chemical binding]; other site
697281006313	catalytic site [active]
697281006314	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
697281006315	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
697281006316	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
697281006317	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
697281006318	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
697281006319	phosphopeptide binding site; other site
697281006320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281006321	Response regulator receiver domain; Region: Response_reg; pfam00072
697281006322	active site
697281006323	phosphorylation site [posttranslational modification]
697281006324	intermolecular recognition site; other site
697281006325	dimerization interface [polypeptide binding]; other site
697281006326	CAAX protease self-immunity; Region: Abi; pfam02517
697281006327	ornithine carbamoyltransferase; Provisional; Region: PRK00779
697281006328	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
697281006329	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
697281006330	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
697281006331	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
697281006332	Coenzyme A binding pocket [chemical binding]; other site
697281006333	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
697281006334	S-adenosylmethionine binding site [chemical binding]; other site
697281006335	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
697281006336	probable galactinol--sucrose galactosyltransferase 1; Region: PLN02355
697281006337	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
697281006338	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
697281006339	TPP-binding site [chemical binding]; other site
697281006340	putative dimer interface [polypeptide binding]; other site
697281006341	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
697281006342	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
697281006343	dimer interface [polypeptide binding]; other site
697281006344	PYR/PP interface [polypeptide binding]; other site
697281006345	TPP binding site [chemical binding]; other site
697281006346	substrate binding site [chemical binding]; other site
697281006347	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179
697281006348	4Fe-4S binding domain; Region: Fer4; pfam00037
697281006349	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
697281006350	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175
697281006351	DEAD-like helicases superfamily; Region: DEXDc; smart00487
697281006352	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
697281006353	ATP binding site [chemical binding]; other site
697281006354	putative Mg++ binding site [ion binding]; other site
697281006355	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
697281006356	nucleotide binding region [chemical binding]; other site
697281006357	ATP-binding site [chemical binding]; other site
697281006358	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
697281006359	Sulfatase; Region: Sulfatase; cl17466
697281006360	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
697281006361	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281006362	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281006363	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281006364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006365	dimer interface [polypeptide binding]; other site
697281006366	conserved gate region; other site
697281006367	putative PBP binding loops; other site
697281006368	ABC-ATPase subunit interface; other site
697281006369	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281006370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006371	dimer interface [polypeptide binding]; other site
697281006372	conserved gate region; other site
697281006373	putative PBP binding loops; other site
697281006374	ABC-ATPase subunit interface; other site
697281006375	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
697281006376	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
697281006377	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
697281006378	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
697281006379	Sulfatase; Region: Sulfatase; cl17466
697281006380	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
697281006381	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
697281006382	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
697281006383	active site 1 [active]
697281006384	dimer interface [polypeptide binding]; other site
697281006385	hexamer interface [polypeptide binding]; other site
697281006386	active site 2 [active]
697281006387	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
697281006388	dimer interface [polypeptide binding]; other site
697281006389	active site
697281006390	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
697281006391	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
697281006392	nucleotide binding site [chemical binding]; other site
697281006393	alpha-mannosidase; Provisional; Region: PRK09819
697281006394	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
697281006395	active site
697281006396	catalytic site [active]
697281006397	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
697281006398	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
697281006399	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
697281006400	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
697281006401	D-xylulose kinase; Region: XylB; TIGR01312
697281006402	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
697281006403	N- and C-terminal domain interface [polypeptide binding]; other site
697281006404	active site
697281006405	MgATP binding site [chemical binding]; other site
697281006406	catalytic site [active]
697281006407	metal binding site [ion binding]; metal-binding site
697281006408	xylulose binding site [chemical binding]; other site
697281006409	homodimer interface [polypeptide binding]; other site
697281006410	Amidohydrolase; Region: Amidohydro_2; pfam04909
697281006411	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281006412	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281006413	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281006414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006415	dimer interface [polypeptide binding]; other site
697281006416	conserved gate region; other site
697281006417	putative PBP binding loops; other site
697281006418	ABC-ATPase subunit interface; other site
697281006419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006420	dimer interface [polypeptide binding]; other site
697281006421	conserved gate region; other site
697281006422	putative PBP binding loops; other site
697281006423	ABC-ATPase subunit interface; other site
697281006424	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281006425	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281006426	DNA binding site [nucleotide binding]
697281006427	domain linker motif; other site
697281006428	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281006429	dimerization interface [polypeptide binding]; other site
697281006430	ligand binding site [chemical binding]; other site
697281006431	Probable beta-xylosidase; Provisional; Region: PLN03080
697281006432	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
697281006433	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
697281006434	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
697281006435	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281006436	putative DNA binding site [nucleotide binding]; other site
697281006437	putative Zn2+ binding site [ion binding]; other site
697281006438	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
697281006439	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
697281006440	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
697281006441	intersubunit interface [polypeptide binding]; other site
697281006442	active site
697281006443	zinc binding site [ion binding]; other site
697281006444	Na+ binding site [ion binding]; other site
697281006445	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
697281006446	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281006447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006448	dimer interface [polypeptide binding]; other site
697281006449	conserved gate region; other site
697281006450	putative PBP binding loops; other site
697281006451	ABC-ATPase subunit interface; other site
697281006452	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
697281006453	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006454	dimer interface [polypeptide binding]; other site
697281006455	conserved gate region; other site
697281006456	putative PBP binding loops; other site
697281006457	ABC-ATPase subunit interface; other site
697281006458	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281006459	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
697281006460	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
697281006461	dimer interface [polypeptide binding]; other site
697281006462	substrate binding site [chemical binding]; other site
697281006463	metal binding site [ion binding]; metal-binding site
697281006464	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
697281006465	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
697281006466	active site
697281006467	catalytic tetrad [active]
697281006468	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
697281006469	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
697281006470	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
697281006471	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
697281006472	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
697281006473	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
697281006474	thiamine phosphate binding site [chemical binding]; other site
697281006475	active site
697281006476	pyrophosphate binding site [ion binding]; other site
697281006477	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
697281006478	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
697281006479	substrate binding site [chemical binding]; other site
697281006480	multimerization interface [polypeptide binding]; other site
697281006481	ATP binding site [chemical binding]; other site
697281006482	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
697281006483	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
697281006484	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
697281006485	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281006486	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281006487	DNA binding residues [nucleotide binding]
697281006488	Putative zinc-finger; Region: zf-HC2; pfam13490
697281006489	Predicted membrane protein [Function unknown]; Region: COG1238
697281006490	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
697281006491	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
697281006492	HSP70 interaction site [polypeptide binding]; other site
697281006493	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
697281006494	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
697281006495	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
697281006496	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
697281006497	DNA-binding site [nucleotide binding]; DNA binding site
697281006498	UTRA domain; Region: UTRA; pfam07702
697281006499	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
697281006500	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281006501	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281006502	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281006503	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
697281006504	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
697281006505	active site
697281006506	trimer interface [polypeptide binding]; other site
697281006507	allosteric site; other site
697281006508	active site lid [active]
697281006509	hexamer (dimer of trimers) interface [polypeptide binding]; other site
697281006510	Right handed beta helix region; Region: Beta_helix; pfam13229
697281006511	WYL domain; Region: WYL; cl14852
697281006512	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
697281006513	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
697281006514	non-heme iron binding site [ion binding]; other site
697281006515	dimer interface [polypeptide binding]; other site
697281006516	Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171
697281006517	non-heme iron binding site [ion binding]; other site
697281006518	dimer interface [polypeptide binding]; other site
697281006519	Rubrerythrin [Energy production and conversion]; Region: COG1592
697281006520	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
697281006521	binuclear metal center [ion binding]; other site
697281006522	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
697281006523	iron binding site [ion binding]; other site
697281006524	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
697281006525	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
697281006526	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
697281006527	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
697281006528	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281006529	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281006530	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281006531	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
697281006532	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
697281006533	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
697281006534	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
697281006535	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
697281006536	Walker A/P-loop; other site
697281006537	ATP binding site [chemical binding]; other site
697281006538	Q-loop/lid; other site
697281006539	ABC transporter signature motif; other site
697281006540	Walker B; other site
697281006541	D-loop; other site
697281006542	H-loop/switch region; other site
697281006543	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
697281006544	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
697281006545	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
697281006546	Walker A/P-loop; other site
697281006547	ATP binding site [chemical binding]; other site
697281006548	Q-loop/lid; other site
697281006549	ABC transporter signature motif; other site
697281006550	Walker B; other site
697281006551	D-loop; other site
697281006552	H-loop/switch region; other site
697281006553	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
697281006554	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
697281006555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006556	dimer interface [polypeptide binding]; other site
697281006557	conserved gate region; other site
697281006558	putative PBP binding loops; other site
697281006559	ABC-ATPase subunit interface; other site
697281006560	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
697281006561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006562	dimer interface [polypeptide binding]; other site
697281006563	conserved gate region; other site
697281006564	putative PBP binding loops; other site
697281006565	ABC-ATPase subunit interface; other site
697281006566	Helix-turn-helix domain; Region: HTH_18; pfam12833
697281006567	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281006568	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
697281006569	germination protein YpeB; Region: spore_YpeB; TIGR02889
697281006570	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
697281006571	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
697281006572	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
697281006573	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
697281006574	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
697281006575	homodimer interface [polypeptide binding]; other site
697281006576	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281006577	catalytic residue [active]
697281006578	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
697281006579	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
697281006580	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281006581	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
697281006582	active site
697281006583	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
697281006584	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
697281006585	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
697281006586	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
697281006587	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
697281006588	galactonate dehydratase; Provisional; Region: PRK14017
697281006589	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
697281006590	metal binding site [ion binding]; metal-binding site
697281006591	substrate binding pocket [chemical binding]; other site
697281006592	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281006593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006594	dimer interface [polypeptide binding]; other site
697281006595	conserved gate region; other site
697281006596	putative PBP binding loops; other site
697281006597	ABC-ATPase subunit interface; other site
697281006598	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006599	dimer interface [polypeptide binding]; other site
697281006600	conserved gate region; other site
697281006601	putative PBP binding loops; other site
697281006602	ABC-ATPase subunit interface; other site
697281006603	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281006604	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281006605	Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662
697281006606	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_5; cd09621
697281006607	putative ligand binding site [chemical binding]; other site
697281006608	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
697281006609	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281006610	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281006611	Cupin domain; Region: Cupin_2; pfam07883
697281006612	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
697281006613	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
697281006614	NAD(P) binding site [chemical binding]; other site
697281006615	active site
697281006616	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281006617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006618	dimer interface [polypeptide binding]; other site
697281006619	conserved gate region; other site
697281006620	ABC-ATPase subunit interface; other site
697281006621	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281006622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006623	dimer interface [polypeptide binding]; other site
697281006624	conserved gate region; other site
697281006625	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
697281006626	ABC-ATPase subunit interface; other site
697281006627	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281006628	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281006629	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281006630	dimerization interface [polypeptide binding]; other site
697281006631	Histidine kinase; Region: His_kinase; pfam06580
697281006632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281006633	ATP binding site [chemical binding]; other site
697281006634	Mg2+ binding site [ion binding]; other site
697281006635	G-X-G motif; other site
697281006636	Response regulator receiver domain; Region: Response_reg; pfam00072
697281006637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281006638	active site
697281006639	phosphorylation site [posttranslational modification]
697281006640	intermolecular recognition site; other site
697281006641	dimerization interface [polypeptide binding]; other site
697281006642	Helix-turn-helix domain; Region: HTH_18; pfam12833
697281006643	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281006644	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
697281006645	classical (c) SDRs; Region: SDR_c; cd05233
697281006646	NAD(P) binding site [chemical binding]; other site
697281006647	active site
697281006648	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
697281006649	classical (c) SDRs; Region: SDR_c; cd05233
697281006650	NAD(P) binding site [chemical binding]; other site
697281006651	active site
697281006652	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
697281006653	dimerization interface [polypeptide binding]; other site
697281006654	putative active cleft [active]
697281006655	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
697281006656	galactonate dehydratase; Provisional; Region: PRK14017
697281006657	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
697281006658	active site pocket [active]
697281006659	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281006660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006661	dimer interface [polypeptide binding]; other site
697281006662	conserved gate region; other site
697281006663	putative PBP binding loops; other site
697281006664	ABC-ATPase subunit interface; other site
697281006665	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281006666	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006667	dimer interface [polypeptide binding]; other site
697281006668	conserved gate region; other site
697281006669	putative PBP binding loops; other site
697281006670	ABC-ATPase subunit interface; other site
697281006671	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281006672	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281006673	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
697281006674	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281006675	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281006676	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281006677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
697281006678	ABC-ATPase subunit interface; other site
697281006679	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281006680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006681	dimer interface [polypeptide binding]; other site
697281006682	conserved gate region; other site
697281006683	ABC-ATPase subunit interface; other site
697281006684	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281006685	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281006686	DNA binding site [nucleotide binding]
697281006687	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
697281006688	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
697281006689	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
697281006690	NAD(P) binding site [chemical binding]; other site
697281006691	catalytic residues [active]
697281006692	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
697281006693	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
697281006694	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
697281006695	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
697281006696	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
697281006697	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
697281006698	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
697281006699	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
697281006700	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
697281006701	putative FMN binding site [chemical binding]; other site
697281006702	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
697281006703	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
697281006704	active site
697281006705	intersubunit interface [polypeptide binding]; other site
697281006706	catalytic residue [active]
697281006707	Bacterial SH3 domain; Region: SH3_3; pfam08239
697281006708	Bacterial SH3 domain; Region: SH3_3; pfam08239
697281006709	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
697281006710	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
697281006711	active site
697281006712	metal binding site [ion binding]; metal-binding site
697281006713	Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; Region: HR1; cl00087
697281006714	Rho binding site 1 [polypeptide binding]; other site
697281006715	putative Rho binding site 2 [polypeptide binding]; other site
697281006716	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
697281006717	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
697281006718	active site
697281006719	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
697281006720	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
697281006721	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
697281006722	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
697281006723	dimerization interface 3.5A [polypeptide binding]; other site
697281006724	active site
697281006725	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
697281006726	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
697281006727	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
697281006728	Walker A/P-loop; other site
697281006729	ATP binding site [chemical binding]; other site
697281006730	Q-loop/lid; other site
697281006731	ABC transporter signature motif; other site
697281006732	Walker B; other site
697281006733	D-loop; other site
697281006734	H-loop/switch region; other site
697281006735	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
697281006736	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
697281006737	Walker A/P-loop; other site
697281006738	ATP binding site [chemical binding]; other site
697281006739	Q-loop/lid; other site
697281006740	ABC transporter signature motif; other site
697281006741	Walker B; other site
697281006742	D-loop; other site
697281006743	H-loop/switch region; other site
697281006744	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
697281006745	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
697281006746	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
697281006747	alphaNTD homodimer interface [polypeptide binding]; other site
697281006748	alphaNTD - beta interaction site [polypeptide binding]; other site
697281006749	alphaNTD - beta' interaction site [polypeptide binding]; other site
697281006750	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
697281006751	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
697281006752	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
697281006753	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
697281006754	RNA binding surface [nucleotide binding]; other site
697281006755	30S ribosomal protein S11; Validated; Region: PRK05309
697281006756	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
697281006757	30S ribosomal protein S13; Region: bact_S13; TIGR03631
697281006758	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
697281006759	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
697281006760	rRNA binding site [nucleotide binding]; other site
697281006761	predicted 30S ribosome binding site; other site
697281006762	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
697281006763	RNA binding site [nucleotide binding]; other site
697281006764	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
697281006765	active site
697281006766	adenylate kinase; Reviewed; Region: adk; PRK00279
697281006767	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
697281006768	AMP-binding site [chemical binding]; other site
697281006769	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
697281006770	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
697281006771	SecY translocase; Region: SecY; pfam00344
697281006772	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
697281006773	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
697281006774	23S rRNA binding site [nucleotide binding]; other site
697281006775	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
697281006776	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
697281006777	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
697281006778	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
697281006779	5S rRNA interface [nucleotide binding]; other site
697281006780	23S rRNA interface [nucleotide binding]; other site
697281006781	L5 interface [polypeptide binding]; other site
697281006782	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
697281006783	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
697281006784	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
697281006785	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
697281006786	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
697281006787	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
697281006788	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
697281006789	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
697281006790	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
697281006791	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
697281006792	RNA binding site [nucleotide binding]; other site
697281006793	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
697281006794	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
697281006795	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
697281006796	putative translocon interaction site; other site
697281006797	23S rRNA interface [nucleotide binding]; other site
697281006798	signal recognition particle (SRP54) interaction site; other site
697281006799	L23 interface [polypeptide binding]; other site
697281006800	trigger factor interaction site; other site
697281006801	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
697281006802	23S rRNA interface [nucleotide binding]; other site
697281006803	5S rRNA interface [nucleotide binding]; other site
697281006804	putative antibiotic binding site [chemical binding]; other site
697281006805	L25 interface [polypeptide binding]; other site
697281006806	L27 interface [polypeptide binding]; other site
697281006807	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
697281006808	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
697281006809	G-X-X-G motif; other site
697281006810	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
697281006811	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
697281006812	protein-rRNA interface [nucleotide binding]; other site
697281006813	putative translocon binding site; other site
697281006814	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
697281006815	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
697281006816	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
697281006817	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
697281006818	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
697281006819	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
697281006820	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
697281006821	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
697281006822	elongation factor Tu; Reviewed; Region: PRK00049
697281006823	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
697281006824	G1 box; other site
697281006825	GEF interaction site [polypeptide binding]; other site
697281006826	GTP/Mg2+ binding site [chemical binding]; other site
697281006827	Switch I region; other site
697281006828	G2 box; other site
697281006829	G3 box; other site
697281006830	Switch II region; other site
697281006831	G4 box; other site
697281006832	G5 box; other site
697281006833	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
697281006834	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
697281006835	Antibiotic Binding Site [chemical binding]; other site
697281006836	elongation factor G; Reviewed; Region: PRK00007
697281006837	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
697281006838	G1 box; other site
697281006839	putative GEF interaction site [polypeptide binding]; other site
697281006840	GTP/Mg2+ binding site [chemical binding]; other site
697281006841	Switch I region; other site
697281006842	G2 box; other site
697281006843	G3 box; other site
697281006844	Switch II region; other site
697281006845	G4 box; other site
697281006846	G5 box; other site
697281006847	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
697281006848	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
697281006849	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
697281006850	30S ribosomal protein S7; Validated; Region: PRK05302
697281006851	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
697281006852	S17 interaction site [polypeptide binding]; other site
697281006853	S8 interaction site; other site
697281006854	16S rRNA interaction site [nucleotide binding]; other site
697281006855	streptomycin interaction site [chemical binding]; other site
697281006856	23S rRNA interaction site [nucleotide binding]; other site
697281006857	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
697281006858	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
697281006859	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
697281006860	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
697281006861	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
697281006862	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
697281006863	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
697281006864	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
697281006865	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
697281006866	G-loop; other site
697281006867	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
697281006868	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
697281006869	DNA binding site [nucleotide binding]
697281006870	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
697281006871	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
697281006872	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
697281006873	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
697281006874	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
697281006875	RPB1 interaction site [polypeptide binding]; other site
697281006876	RPB10 interaction site [polypeptide binding]; other site
697281006877	RPB11 interaction site [polypeptide binding]; other site
697281006878	RPB3 interaction site [polypeptide binding]; other site
697281006879	RPB12 interaction site [polypeptide binding]; other site
697281006880	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
697281006881	core dimer interface [polypeptide binding]; other site
697281006882	peripheral dimer interface [polypeptide binding]; other site
697281006883	L10 interface [polypeptide binding]; other site
697281006884	L11 interface [polypeptide binding]; other site
697281006885	putative EF-Tu interaction site [polypeptide binding]; other site
697281006886	putative EF-G interaction site [polypeptide binding]; other site
697281006887	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
697281006888	23S rRNA interface [nucleotide binding]; other site
697281006889	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
697281006890	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
697281006891	mRNA/rRNA interface [nucleotide binding]; other site
697281006892	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
697281006893	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
697281006894	23S rRNA interface [nucleotide binding]; other site
697281006895	L7/L12 interface [polypeptide binding]; other site
697281006896	putative thiostrepton binding site; other site
697281006897	L25 interface [polypeptide binding]; other site
697281006898	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
697281006899	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
697281006900	putative homodimer interface [polypeptide binding]; other site
697281006901	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
697281006902	heterodimer interface [polypeptide binding]; other site
697281006903	homodimer interface [polypeptide binding]; other site
697281006904	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
697281006905	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
697281006906	elongation factor Tu; Reviewed; Region: PRK00049
697281006907	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
697281006908	G1 box; other site
697281006909	GEF interaction site [polypeptide binding]; other site
697281006910	GTP/Mg2+ binding site [chemical binding]; other site
697281006911	Switch I region; other site
697281006912	G2 box; other site
697281006913	G3 box; other site
697281006914	Switch II region; other site
697281006915	G4 box; other site
697281006916	G5 box; other site
697281006917	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
697281006918	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
697281006919	Antibiotic Binding Site [chemical binding]; other site
697281006920	RNA polymerase factor sigma-70; Validated; Region: PRK08295
697281006921	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281006922	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
697281006923	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
697281006924	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
697281006925	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
697281006926	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
697281006927	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
697281006928	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
697281006929	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
697281006930	alanine racemase; Reviewed; Region: alr; PRK00053
697281006931	active site
697281006932	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
697281006933	dimer interface [polypeptide binding]; other site
697281006934	substrate binding site [chemical binding]; other site
697281006935	catalytic residues [active]
697281006936	ACT domain-containing protein [General function prediction only]; Region: COG4747
697281006937	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
697281006938	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
697281006939	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
697281006940	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
697281006941	acyl-activating enzyme (AAE) consensus motif; other site
697281006942	AMP binding site [chemical binding]; other site
697281006943	active site
697281006944	CoA binding site [chemical binding]; other site
697281006945	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
697281006946	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
697281006947	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
697281006948	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
697281006949	dimer interface [polypeptide binding]; other site
697281006950	PYR/PP interface [polypeptide binding]; other site
697281006951	TPP binding site [chemical binding]; other site
697281006952	substrate binding site [chemical binding]; other site
697281006953	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
697281006954	TPP-binding site; other site
697281006955	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
697281006956	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
697281006957	acyl-activating enzyme (AAE) consensus motif; other site
697281006958	AMP binding site [chemical binding]; other site
697281006959	active site
697281006960	CoA binding site [chemical binding]; other site
697281006961	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
697281006962	Na binding site [ion binding]; other site
697281006963	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
697281006964	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
697281006965	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
697281006966	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
697281006967	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281006968	ABC-ATPase subunit interface; other site
697281006969	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
697281006970	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
697281006971	Walker A/P-loop; other site
697281006972	ATP binding site [chemical binding]; other site
697281006973	Q-loop/lid; other site
697281006974	ABC transporter signature motif; other site
697281006975	Walker B; other site
697281006976	D-loop; other site
697281006977	H-loop/switch region; other site
697281006978	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
697281006979	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
697281006980	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281006981	dimerization interface [polypeptide binding]; other site
697281006982	putative Zn2+ binding site [ion binding]; other site
697281006983	putative DNA binding site [nucleotide binding]; other site
697281006984	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281006985	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
697281006986	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281006987	Walker A/P-loop; other site
697281006988	ATP binding site [chemical binding]; other site
697281006989	Q-loop/lid; other site
697281006990	ABC transporter signature motif; other site
697281006991	Walker B; other site
697281006992	D-loop; other site
697281006993	H-loop/switch region; other site
697281006994	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281006995	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
697281006996	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
697281006997	Walker A/P-loop; other site
697281006998	ATP binding site [chemical binding]; other site
697281006999	Q-loop/lid; other site
697281007000	ABC transporter signature motif; other site
697281007001	Walker B; other site
697281007002	D-loop; other site
697281007003	H-loop/switch region; other site
697281007004	alpha-glucosidase; Provisional; Region: PRK10426
697281007005	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
697281007006	putative active site [active]
697281007007	putative catalytic site [active]
697281007008	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
697281007009	ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266
697281007010	Walker A/P-loop; other site
697281007011	ATP binding site [chemical binding]; other site
697281007012	Q-loop/lid; other site
697281007013	ABC transporter signature motif; other site
697281007014	Walker B; other site
697281007015	D-loop; other site
697281007016	H-loop/switch region; other site
697281007017	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
697281007018	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
697281007019	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
697281007020	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
697281007021	G1 box; other site
697281007022	GTP/Mg2+ binding site [chemical binding]; other site
697281007023	Switch I region; other site
697281007024	G2 box; other site
697281007025	Switch II region; other site
697281007026	G3 box; other site
697281007027	G4 box; other site
697281007028	G5 box; other site
697281007029	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
697281007030	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
697281007031	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
697281007032	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
697281007033	active site
697281007034	motif I; other site
697281007035	motif II; other site
697281007036	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
697281007037	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
697281007038	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
697281007039	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
697281007040	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
697281007041	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
697281007042	CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592
697281007043	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
697281007044	Family of unknown function (DUF694); Region: DUF694; pfam05107
697281007045	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730
697281007046	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
697281007047	HerA helicase [Replication, recombination, and repair]; Region: COG0433
697281007048	Domain of unknown function DUF87; Region: DUF87; pfam01935
697281007049	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
697281007050	NurA domain; Region: NurA; pfam09376
697281007051	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
697281007052	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
697281007053	Predicted methyltransferases [General function prediction only]; Region: COG0313
697281007054	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
697281007055	putative SAM binding site [chemical binding]; other site
697281007056	putative homodimer interface [polypeptide binding]; other site
697281007057	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
697281007058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
697281007059	S-adenosylmethionine binding site [chemical binding]; other site
697281007060	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
697281007061	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
697281007062	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
697281007063	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
697281007064	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
697281007065	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
697281007066	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
697281007067	Walker A/P-loop; other site
697281007068	ATP binding site [chemical binding]; other site
697281007069	Q-loop/lid; other site
697281007070	ABC transporter signature motif; other site
697281007071	Walker B; other site
697281007072	D-loop; other site
697281007073	H-loop/switch region; other site
697281007074	galactonate dehydratase; Provisional; Region: PRK14017
697281007075	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
697281007076	putative active site pocket [active]
697281007077	putative metal binding site [ion binding]; other site
697281007078	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
697281007079	active site
697281007080	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
697281007081	dimer interface [polypeptide binding]; other site
697281007082	substrate binding site [chemical binding]; other site
697281007083	catalytic residues [active]
697281007084	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
697281007085	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
697281007086	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
697281007087	active site
697281007088	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
697281007089	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
697281007090	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
697281007091	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
697281007092	active site
697281007093	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281007094	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007095	dimer interface [polypeptide binding]; other site
697281007096	conserved gate region; other site
697281007097	putative PBP binding loops; other site
697281007098	ABC-ATPase subunit interface; other site
697281007099	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
697281007100	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007101	dimer interface [polypeptide binding]; other site
697281007102	putative PBP binding loops; other site
697281007103	ABC-ATPase subunit interface; other site
697281007104	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281007105	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281007106	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
697281007107	DNA-binding site [nucleotide binding]; DNA binding site
697281007108	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281007109	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281007110	dimerization interface [polypeptide binding]; other site
697281007111	ligand binding site [chemical binding]; other site
697281007112	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281007113	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281007114	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281007115	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
697281007116	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
697281007117	Rubrerythrin [Energy production and conversion]; Region: COG1592
697281007118	iron binding site [ion binding]; other site
697281007119	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
697281007120	catalytic residues [active]
697281007121	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
697281007122	Zn binding site [ion binding]; other site
697281007123	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
697281007124	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
697281007125	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
697281007126	Walker A/P-loop; other site
697281007127	ATP binding site [chemical binding]; other site
697281007128	Q-loop/lid; other site
697281007129	ABC transporter signature motif; other site
697281007130	Walker B; other site
697281007131	D-loop; other site
697281007132	H-loop/switch region; other site
697281007133	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
697281007134	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007135	dimer interface [polypeptide binding]; other site
697281007136	conserved gate region; other site
697281007137	putative PBP binding loops; other site
697281007138	ABC-ATPase subunit interface; other site
697281007139	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
697281007140	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
697281007141	Walker A/P-loop; other site
697281007142	ATP binding site [chemical binding]; other site
697281007143	Q-loop/lid; other site
697281007144	ABC transporter signature motif; other site
697281007145	Walker B; other site
697281007146	D-loop; other site
697281007147	H-loop/switch region; other site
697281007148	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
697281007149	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
697281007150	substrate binding pocket [chemical binding]; other site
697281007151	membrane-bound complex binding site; other site
697281007152	hinge residues; other site
697281007153	aromatic acid decarboxylase; Validated; Region: PRK05920
697281007154	Flavoprotein; Region: Flavoprotein; pfam02441
697281007155	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
697281007156	UbiA prenyltransferase family; Region: UbiA; pfam01040
697281007157	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
697281007158	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
697281007159	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
697281007160	active site
697281007161	nucleophile elbow; other site
697281007162	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
697281007163	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
697281007164	substrate-cofactor binding pocket; other site
697281007165	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281007166	catalytic residue [active]
697281007167	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
697281007168	putative FMN binding site [chemical binding]; other site
697281007169	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
697281007170	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
697281007171	ring oligomerisation interface [polypeptide binding]; other site
697281007172	ATP/Mg binding site [chemical binding]; other site
697281007173	stacking interactions; other site
697281007174	hinge regions; other site
697281007175	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
697281007176	oligomerisation interface [polypeptide binding]; other site
697281007177	mobile loop; other site
697281007178	roof hairpin; other site
697281007179	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
697281007180	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
697281007181	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
697281007182	minor groove reading motif; other site
697281007183	helix-hairpin-helix signature motif; other site
697281007184	substrate binding pocket [chemical binding]; other site
697281007185	active site
697281007186	putative oxidoreductase; Provisional; Region: PRK12831
697281007187	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
697281007188	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
697281007189	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
697281007190	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
697281007191	FAD binding pocket [chemical binding]; other site
697281007192	FAD binding motif [chemical binding]; other site
697281007193	phosphate binding motif [ion binding]; other site
697281007194	beta-alpha-beta structure motif; other site
697281007195	NAD binding pocket [chemical binding]; other site
697281007196	Iron coordination center [ion binding]; other site
697281007197	Isopentenyl transferase; Region: IPT; pfam01745
697281007198	Asp23 family; Region: Asp23; pfam03780
697281007199	AAA domain; Region: AAA_32; pfam13654
697281007200	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
697281007201	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
697281007202	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
697281007203	DNA-binding site [nucleotide binding]; DNA binding site
697281007204	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
697281007205	pyridoxal 5'-phosphate binding site [chemical binding]; other site
697281007206	homodimer interface [polypeptide binding]; other site
697281007207	catalytic residue [active]
697281007208	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
697281007209	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
697281007210	active site
697281007211	multimer interface [polypeptide binding]; other site
697281007212	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
697281007213	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
697281007214	predicted active site [active]
697281007215	catalytic triad [active]
697281007216	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281007217	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
697281007218	active site
697281007219	ADP/pyrophosphate binding site [chemical binding]; other site
697281007220	dimerization interface [polypeptide binding]; other site
697281007221	allosteric effector site; other site
697281007222	fructose-1,6-bisphosphate binding site; other site
697281007223	Helix-turn-helix domain; Region: HTH_28; pfam13518
697281007224	Winged helix-turn helix; Region: HTH_29; pfam13551
697281007225	Integrase core domain; Region: rve; pfam00665
697281007226	Integrase core domain; Region: rve_3; cl15866
697281007227	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
697281007228	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
697281007229	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
697281007230	Metal-binding active site; metal-binding site
697281007231	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
697281007232	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281007233	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281007234	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281007235	non-specific DNA binding site [nucleotide binding]; other site
697281007236	Winged helix-turn helix; Region: HTH_29; pfam13551
697281007237	salt bridge; other site
697281007238	sequence-specific DNA binding site [nucleotide binding]; other site
697281007239	transposase; Provisional; Region: PRK06526
697281007240	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
697281007241	Walker A motif; other site
697281007242	ATP binding site [chemical binding]; other site
697281007243	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
697281007244	non-specific DNA binding site [nucleotide binding]; other site
697281007245	salt bridge; other site
697281007246	sequence-specific DNA binding site [nucleotide binding]; other site
697281007247	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
697281007248	DNA methylase; Region: N6_N4_Mtase; pfam01555
697281007249	DNA methylase; Region: N6_N4_Mtase; cl17433
697281007250	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
697281007251	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
697281007252	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
697281007253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281007254	AAA domain; Region: AAA_21; pfam13304
697281007255	Walker A/P-loop; other site
697281007256	ATP binding site [chemical binding]; other site
697281007257	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
697281007258	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
697281007259	Walker B; other site
697281007260	D-loop; other site
697281007261	H-loop/switch region; other site
697281007262	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
697281007263	putative active site [active]
697281007264	putative metal-binding site [ion binding]; other site
697281007265	Membrane transport protein; Region: Mem_trans; pfam03547
697281007266	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
697281007267	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
697281007268	putative active site [active]
697281007269	putative metal binding site [ion binding]; other site
697281007270	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
697281007271	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
697281007272	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
697281007273	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
697281007274	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
697281007275	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
697281007276	PYR/PP interface [polypeptide binding]; other site
697281007277	dimer interface [polypeptide binding]; other site
697281007278	TPP binding site [chemical binding]; other site
697281007279	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
697281007280	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
697281007281	TPP-binding site [chemical binding]; other site
697281007282	dimer interface [polypeptide binding]; other site
697281007283	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
697281007284	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
697281007285	NAD(P) binding site [chemical binding]; other site
697281007286	active site
697281007287	ribulokinase; Provisional; Region: PRK04123
697281007288	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
697281007289	N- and C-terminal domain interface [polypeptide binding]; other site
697281007290	active site
697281007291	MgATP binding site [chemical binding]; other site
697281007292	catalytic site [active]
697281007293	metal binding site [ion binding]; metal-binding site
697281007294	carbohydrate binding site [chemical binding]; other site
697281007295	homodimer interface [polypeptide binding]; other site
697281007296	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
697281007297	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
697281007298	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
697281007299	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
697281007300	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
697281007301	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
697281007302	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281007303	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
697281007304	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
697281007305	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281007306	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281007307	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281007308	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281007309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007310	dimer interface [polypeptide binding]; other site
697281007311	conserved gate region; other site
697281007312	ABC-ATPase subunit interface; other site
697281007313	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281007314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007315	dimer interface [polypeptide binding]; other site
697281007316	conserved gate region; other site
697281007317	ABC-ATPase subunit interface; other site
697281007318	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
697281007319	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
697281007320	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
697281007321	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
697281007322	active site
697281007323	catalytic tetrad [active]
697281007324	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
697281007325	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
697281007326	putative NAD(P) binding site [chemical binding]; other site
697281007327	catalytic Zn binding site [ion binding]; other site
697281007328	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
697281007329	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
697281007330	N- and C-terminal domain interface [polypeptide binding]; other site
697281007331	putative active site [active]
697281007332	MgATP binding site [chemical binding]; other site
697281007333	catalytic site [active]
697281007334	metal binding site [ion binding]; metal-binding site
697281007335	putative xylulose binding site [chemical binding]; other site
697281007336	putative homodimer interface [polypeptide binding]; other site
697281007337	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281007338	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281007339	DNA binding site [nucleotide binding]
697281007340	domain linker motif; other site
697281007341	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281007342	dimerization interface [polypeptide binding]; other site
697281007343	ligand binding site [chemical binding]; other site
697281007344	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
697281007345	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
697281007346	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
697281007347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281007348	Walker A/P-loop; other site
697281007349	ATP binding site [chemical binding]; other site
697281007350	Q-loop/lid; other site
697281007351	ABC transporter signature motif; other site
697281007352	Walker B; other site
697281007353	D-loop; other site
697281007354	H-loop/switch region; other site
697281007355	ABC transporter; Region: ABC_tran_2; pfam12848
697281007356	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
697281007357	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
697281007358	dinuclear metal binding motif [ion binding]; other site
697281007359	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
697281007360	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
697281007361	homotrimer interaction site [polypeptide binding]; other site
697281007362	putative active site [active]
697281007363	Uncharacterized conserved protein [Function unknown]; Region: COG2006
697281007364	Domain of unknown function (DUF362); Region: DUF362; pfam04015
697281007365	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
697281007366	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
697281007367	short chain dehydrogenase; Validated; Region: PRK06182
697281007368	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
697281007369	NADP binding site [chemical binding]; other site
697281007370	active site
697281007371	steroid binding site; other site
697281007372	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
697281007373	hypothetical protein; Provisional; Region: PRK02877
697281007374	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
697281007375	nucleoside/Zn binding site; other site
697281007376	dimer interface [polypeptide binding]; other site
697281007377	catalytic motif [active]
697281007378	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281007379	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007380	dimer interface [polypeptide binding]; other site
697281007381	conserved gate region; other site
697281007382	putative PBP binding loops; other site
697281007383	ABC-ATPase subunit interface; other site
697281007384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
697281007385	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
697281007386	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007387	dimer interface [polypeptide binding]; other site
697281007388	conserved gate region; other site
697281007389	putative PBP binding loops; other site
697281007390	ABC-ATPase subunit interface; other site
697281007391	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281007392	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281007393	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
697281007394	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281007395	FeS/SAM binding site; other site
697281007396	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
697281007397	Pyruvate formate lyase 1; Region: PFL1; cd01678
697281007398	coenzyme A binding site [chemical binding]; other site
697281007399	active site
697281007400	catalytic residues [active]
697281007401	glycine loop; other site
697281007402	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
697281007403	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
697281007404	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
697281007405	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
697281007406	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
697281007407	active site residue [active]
697281007408	Cupin domain; Region: Cupin_2; pfam07883
697281007409	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281007410	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281007411	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281007412	alpha-galactosidase; Provisional; Region: PRK15076
697281007413	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
697281007414	NAD binding site [chemical binding]; other site
697281007415	sugar binding site [chemical binding]; other site
697281007416	divalent metal binding site [ion binding]; other site
697281007417	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
697281007418	dimer interface [polypeptide binding]; other site
697281007419	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
697281007420	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
697281007421	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
697281007422	Walker A/P-loop; other site
697281007423	ATP binding site [chemical binding]; other site
697281007424	Q-loop/lid; other site
697281007425	ABC transporter signature motif; other site
697281007426	Walker B; other site
697281007427	D-loop; other site
697281007428	H-loop/switch region; other site
697281007429	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
697281007430	DNA-binding site [nucleotide binding]; DNA binding site
697281007431	HEPN domain; Region: HEPN; pfam05168
697281007432	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
697281007433	active site
697281007434	NTP binding site [chemical binding]; other site
697281007435	metal binding triad [ion binding]; metal-binding site
697281007436	antibiotic binding site [chemical binding]; other site
697281007437	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
697281007438	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
697281007439	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
697281007440	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
697281007441	Walker A/P-loop; other site
697281007442	ATP binding site [chemical binding]; other site
697281007443	Q-loop/lid; other site
697281007444	ABC transporter signature motif; other site
697281007445	Walker B; other site
697281007446	D-loop; other site
697281007447	H-loop/switch region; other site
697281007448	Uncharacterized conserved protein [Function unknown]; Region: COG1633
697281007449	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
697281007450	diiron binding motif [ion binding]; other site
697281007451	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
697281007452	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
697281007453	hexamer (dimer of trimers) interface [polypeptide binding]; other site
697281007454	substrate binding site [chemical binding]; other site
697281007455	trimer interface [polypeptide binding]; other site
697281007456	Mn binding site [ion binding]; other site
697281007457	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
697281007458	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
697281007459	putative catalytic cysteine [active]
697281007460	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
697281007461	putative active site [active]
697281007462	metal binding site [ion binding]; metal-binding site
697281007463	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
697281007464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281007465	Walker A motif; other site
697281007466	ATP binding site [chemical binding]; other site
697281007467	Walker B motif; other site
697281007468	arginine finger; other site
697281007469	Peptidase family M41; Region: Peptidase_M41; pfam01434
697281007470	Uncharacterized conserved protein [Function unknown]; Region: COG2006
697281007471	Domain of unknown function (DUF362); Region: DUF362; pfam04015
697281007472	glycerol kinase; Provisional; Region: glpK; PRK00047
697281007473	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
697281007474	N- and C-terminal domain interface [polypeptide binding]; other site
697281007475	active site
697281007476	MgATP binding site [chemical binding]; other site
697281007477	catalytic site [active]
697281007478	metal binding site [ion binding]; metal-binding site
697281007479	glycerol binding site [chemical binding]; other site
697281007480	homotetramer interface [polypeptide binding]; other site
697281007481	homodimer interface [polypeptide binding]; other site
697281007482	FBP binding site [chemical binding]; other site
697281007483	protein IIAGlc interface [polypeptide binding]; other site
697281007484	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
697281007485	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
697281007486	Substrate binding site; other site
697281007487	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
697281007488	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
697281007489	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
697281007490	active site
697281007491	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
697281007492	Domain of unknown function (DUF377); Region: DUF377; pfam04041
697281007493	active site
697281007494	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
697281007495	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
697281007496	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
697281007497	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
697281007498	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
697281007499	NAD-dependent deacetylase; Provisional; Region: PRK00481
697281007500	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
697281007501	NAD+ binding site [chemical binding]; other site
697281007502	substrate binding site [chemical binding]; other site
697281007503	Zn binding site [ion binding]; other site
697281007504	carbon storage regulator; Provisional; Region: PRK01712
697281007505	flagellar assembly protein FliW; Provisional; Region: PRK13285
697281007506	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
697281007507	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
697281007508	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
697281007509	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
697281007510	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
697281007511	FlgN protein; Region: FlgN; pfam05130
697281007512	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
697281007513	flagellar operon protein TIGR03826; Region: YvyF
697281007514	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
697281007515	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
697281007516	active site
697281007517	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
697281007518	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
697281007519	DNA binding site [nucleotide binding]
697281007520	AAA domain; Region: AAA_30; pfam13604
697281007521	Family description; Region: UvrD_C_2; pfam13538
697281007522	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
697281007523	active site
697281007524	substrate-binding site [chemical binding]; other site
697281007525	metal-binding site [ion binding]
697281007526	GTP binding site [chemical binding]; other site
697281007527	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
697281007528	Clp amino terminal domain; Region: Clp_N; pfam02861
697281007529	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281007530	Walker A motif; other site
697281007531	ATP binding site [chemical binding]; other site
697281007532	Walker B motif; other site
697281007533	arginine finger; other site
697281007534	UvrB/uvrC motif; Region: UVR; pfam02151
697281007535	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281007536	Walker A motif; other site
697281007537	ATP binding site [chemical binding]; other site
697281007538	Walker B motif; other site
697281007539	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
697281007540	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
697281007541	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
697281007542	putative dimer interface [polypeptide binding]; other site
697281007543	Rubredoxin [Energy production and conversion]; Region: COG1773
697281007544	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
697281007545	iron binding site [ion binding]; other site
697281007546	Coat F domain; Region: Coat_F; pfam07875
697281007547	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
697281007548	dinuclear metal binding motif [ion binding]; other site
697281007549	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
697281007550	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
697281007551	substrate binding site [chemical binding]; other site
697281007552	dimer interface [polypeptide binding]; other site
697281007553	ATP binding site [chemical binding]; other site
697281007554	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
697281007555	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
697281007556	active site
697281007557	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
697281007558	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
697281007559	putative ligand binding site [chemical binding]; other site
697281007560	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
697281007561	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
697281007562	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
697281007563	TM-ABC transporter signature motif; other site
697281007564	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
697281007565	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
697281007566	Walker A/P-loop; other site
697281007567	ATP binding site [chemical binding]; other site
697281007568	Q-loop/lid; other site
697281007569	ABC transporter signature motif; other site
697281007570	Walker B; other site
697281007571	D-loop; other site
697281007572	H-loop/switch region; other site
697281007573	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
697281007574	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
697281007575	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
697281007576	putative ligand binding site [chemical binding]; other site
697281007577	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
697281007578	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
697281007579	putative ligand binding site [chemical binding]; other site
697281007580	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
697281007581	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281007582	active site
697281007583	phosphorylation site [posttranslational modification]
697281007584	intermolecular recognition site; other site
697281007585	dimerization interface [polypeptide binding]; other site
697281007586	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281007587	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281007588	CHASE3 domain; Region: CHASE3; cl05000
697281007589	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
697281007590	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281007591	dimerization interface [polypeptide binding]; other site
697281007592	Histidine kinase; Region: His_kinase; pfam06580
697281007593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281007594	ATP binding site [chemical binding]; other site
697281007595	Mg2+ binding site [ion binding]; other site
697281007596	G-X-G motif; other site
697281007597	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
697281007598	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
697281007599	ligand binding site [chemical binding]; other site
697281007600	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281007601	dimerization interface [polypeptide binding]; other site
697281007602	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
697281007603	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
697281007604	metal binding site [ion binding]; metal-binding site
697281007605	active site
697281007606	I-site; other site
697281007607	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
697281007608	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281007609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007610	ABC-ATPase subunit interface; other site
697281007611	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281007612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007613	dimer interface [polypeptide binding]; other site
697281007614	conserved gate region; other site
697281007615	ABC-ATPase subunit interface; other site
697281007616	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281007617	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281007618	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
697281007619	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
697281007620	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
697281007621	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
697281007622	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
697281007623	CotJB protein; Region: CotJB; pfam12652
697281007624	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
697281007625	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
697281007626	RRXRR protein; Region: RRXRR; pfam14239
697281007627	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
697281007628	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
697281007629	active site
697281007630	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
697281007631	Zn2+ binding site [ion binding]; other site
697281007632	Mg2+ binding site [ion binding]; other site
697281007633	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
697281007634	PRTRC system protein D; Region: PRTRC_D; TIGR03739
697281007635	Mg binding site [ion binding]; other site
697281007636	nucleotide binding site [chemical binding]; other site
697281007637	putative protofilament interface [polypeptide binding]; other site
697281007638	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
697281007639	AAA domain; Region: AAA_31; pfam13614
697281007640	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
697281007641	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
697281007642	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
697281007643	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
697281007644	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
697281007645	Walker A motif; other site
697281007646	ATP binding site [chemical binding]; other site
697281007647	Walker B motif; other site
697281007648	AAA domain; Region: AAA_31; pfam13614
697281007649	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
697281007650	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
697281007651	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281007652	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
697281007653	Peptidase family M23; Region: Peptidase_M23; pfam01551
697281007654	TadE-like protein; Region: TadE; pfam07811
697281007655	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
697281007656	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
697281007657	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
697281007658	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
697281007659	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
697281007660	Walker A motif; other site
697281007661	ATP binding site [chemical binding]; other site
697281007662	Walker B motif; other site
697281007663	AAA domain; Region: AAA_31; pfam13614
697281007664	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
697281007665	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
697281007666	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
697281007667	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
697281007668	RRXRR protein; Region: RRXRR; pfam14239
697281007669	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
697281007670	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
697281007671	active site
697281007672	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
697281007673	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
697281007674	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
697281007675	N-acetyl-D-glucosamine binding site [chemical binding]; other site
697281007676	catalytic residue [active]
697281007677	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
697281007678	Peptidase family M23; Region: Peptidase_M23; pfam01551
697281007679	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
697281007680	active site
697281007681	NTP binding site [chemical binding]; other site
697281007682	metal binding triad [ion binding]; metal-binding site
697281007683	antibiotic binding site [chemical binding]; other site
697281007684	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
697281007685	putative active site [active]
697281007686	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
697281007687	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281007688	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281007689	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281007690	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
697281007691	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
697281007692	Domain of unknown function DUF87; Region: DUF87; pfam01935
697281007693	AAA-like domain; Region: AAA_10; pfam12846
697281007694	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
697281007695	PrgI family protein; Region: PrgI; pfam12666
697281007696	DNA primase; Provisional; Region: 61; PHA02540
697281007697	CHC2 zinc finger; Region: zf-CHC2; cl17510
697281007698	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
697281007699	active site
697281007700	metal binding site [ion binding]; metal-binding site
697281007701	interdomain interaction site; other site
697281007702	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
697281007703	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
697281007704	MPN+ (JAMM) motif; other site
697281007705	Zinc-binding site [ion binding]; other site
697281007706	DNA polymerase III subunit beta; Validated; Region: PRK05643
697281007707	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
697281007708	putative DNA binding surface [nucleotide binding]; other site
697281007709	dimer interface [polypeptide binding]; other site
697281007710	beta-clamp/clamp loader binding surface; other site
697281007711	beta-clamp/translesion DNA polymerase binding surface; other site
697281007712	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
697281007713	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
697281007714	dimer interface [polypeptide binding]; other site
697281007715	ssDNA binding site [nucleotide binding]; other site
697281007716	tetramer (dimer of dimers) interface [polypeptide binding]; other site
697281007717	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
697281007718	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281007719	sequence-specific DNA binding site [nucleotide binding]; other site
697281007720	salt bridge; other site
697281007721	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
697281007722	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281007723	non-specific DNA binding site [nucleotide binding]; other site
697281007724	salt bridge; other site
697281007725	sequence-specific DNA binding site [nucleotide binding]; other site
697281007726	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281007727	sequence-specific DNA binding site [nucleotide binding]; other site
697281007728	salt bridge; other site
697281007729	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
697281007730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281007731	Walker A motif; other site
697281007732	ATP binding site [chemical binding]; other site
697281007733	Walker B motif; other site
697281007734	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
697281007735	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
697281007736	active site
697281007737	NTP binding site [chemical binding]; other site
697281007738	metal binding triad [ion binding]; metal-binding site
697281007739	antibiotic binding site [chemical binding]; other site
697281007740	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
697281007741	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281007742	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281007743	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
697281007744	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
697281007745	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
697281007746	RNA/DNA hybrid binding site [nucleotide binding]; other site
697281007747	active site
697281007748	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
697281007749	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
697281007750	active site
697281007751	DNA binding site [nucleotide binding]
697281007752	Int/Topo IB signature motif; other site
697281007753	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
697281007754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
697281007755	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
697281007756	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
697281007757	metal ion-dependent adhesion site (MIDAS); other site
697281007758	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281007759	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
697281007760	Walker A motif; other site
697281007761	ATP binding site [chemical binding]; other site
697281007762	Walker B motif; other site
697281007763	arginine finger; other site
697281007764	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
697281007765	active site
697281007766	transposase; Provisional; Region: PRK06526
697281007767	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281007768	Walker A motif; other site
697281007769	ATP binding site [chemical binding]; other site
697281007770	Walker B motif; other site
697281007771	arginine finger; other site
697281007772	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281007773	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
697281007774	non-specific DNA binding site [nucleotide binding]; other site
697281007775	salt bridge; other site
697281007776	sequence-specific DNA binding site [nucleotide binding]; other site
697281007777	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
697281007778	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281007779	Walker A/P-loop; other site
697281007780	ATP binding site [chemical binding]; other site
697281007781	Q-loop/lid; other site
697281007782	ABC transporter signature motif; other site
697281007783	Walker B; other site
697281007784	D-loop; other site
697281007785	H-loop/switch region; other site
697281007786	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
697281007787	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
697281007788	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
697281007789	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
697281007790	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
697281007791	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
697281007792	active site
697281007793	metal-binding site [ion binding]
697281007794	nucleotide-binding site [chemical binding]; other site
697281007795	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
697281007796	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
697281007797	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
697281007798	active site
697281007799	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281007800	Radical SAM superfamily; Region: Radical_SAM; pfam04055
697281007801	FeS/SAM binding site; other site
697281007802	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281007803	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
697281007804	Walker A motif; other site
697281007805	ATP binding site [chemical binding]; other site
697281007806	Walker B motif; other site
697281007807	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
697281007808	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
697281007809	FeS/SAM binding site; other site
697281007810	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
697281007811	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
697281007812	RRXRR protein; Region: RRXRR; pfam14239
697281007813	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
697281007814	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
697281007815	active site
697281007816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
697281007817	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
697281007818	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
697281007819	metal ion-dependent adhesion site (MIDAS); other site
697281007820	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281007821	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
697281007822	Walker A motif; other site
697281007823	ATP binding site [chemical binding]; other site
697281007824	Walker B motif; other site
697281007825	arginine finger; other site
697281007826	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
697281007827	active site
697281007828	Ion transport protein; Region: Ion_trans; pfam00520
697281007829	Ion channel; Region: Ion_trans_2; pfam07885
697281007830	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
697281007831	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
697281007832	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
697281007833	Transposase [DNA replication, recombination, and repair]; Region: COG5421
697281007834	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
697281007835	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281007836	Walker A motif; other site
697281007837	ATP binding site [chemical binding]; other site
697281007838	Walker B motif; other site
697281007839	Family description; Region: UvrD_C_2; pfam13538
697281007840	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
697281007841	Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040
697281007842	CRISPR/Cas system-associated RAMP superfamily protein Csf3; Region: Csf3_U; cl11865
697281007843	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
697281007844	CRISPR/Cas system-associated protein Csf1; Region: Csf1_U; cd09705
697281007845	EXLDI protein; Region: EXLDI; TIGR04342
697281007846	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
697281007847	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
697281007848	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
697281007849	ATP binding site [chemical binding]; other site
697281007850	putative Mg++ binding site [ion binding]; other site
697281007851	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
697281007852	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
697281007853	HsdM N-terminal domain; Region: HsdM_N; pfam12161
697281007854	Methyltransferase domain; Region: Methyltransf_26; pfam13659
697281007855	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
697281007856	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
697281007857	Transposase; Region: HTH_Tnp_1; pfam01527
697281007858	Helix-turn-helix domain; Region: HTH_36; pfam13730
697281007859	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
697281007860	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
697281007861	RNA binding site [nucleotide binding]; other site
697281007862	homodimer interface [polypeptide binding]; other site
697281007863	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
697281007864	RNA binding site [nucleotide binding]; other site
697281007865	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
697281007866	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
697281007867	Walker A motif; other site
697281007868	ATP binding site [chemical binding]; other site
697281007869	Walker B motif; other site
697281007870	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
697281007871	Domain of unknown function (DUF955); Region: DUF955; pfam06114
697281007872	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
697281007873	catalytic residues [active]
697281007874	catalytic nucleophile [active]
697281007875	Recombinase; Region: Recombinase; pfam07508
697281007876	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
697281007877	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
697281007878	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281007879	non-specific DNA binding site [nucleotide binding]; other site
697281007880	salt bridge; other site
697281007881	sequence-specific DNA binding site [nucleotide binding]; other site
697281007882	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007883	dimer interface [polypeptide binding]; other site
697281007884	conserved gate region; other site
697281007885	putative PBP binding loops; other site
697281007886	ABC-ATPase subunit interface; other site
697281007887	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281007888	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281007889	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281007890	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007891	dimer interface [polypeptide binding]; other site
697281007892	conserved gate region; other site
697281007893	putative PBP binding loops; other site
697281007894	ABC-ATPase subunit interface; other site
697281007895	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
697281007896	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281007897	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281007898	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281007899	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
697281007900	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281007901	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281007902	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281007903	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281007904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007905	ABC-ATPase subunit interface; other site
697281007906	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281007907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007908	dimer interface [polypeptide binding]; other site
697281007909	conserved gate region; other site
697281007910	ABC-ATPase subunit interface; other site
697281007911	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
697281007912	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281007913	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281007914	DNA binding residues [nucleotide binding]
697281007915	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
697281007916	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
697281007917	YvrJ protein family; Region: YvrJ; pfam12841
697281007918	YabG peptidase U57; Region: Peptidase_U57; cl05250
697281007919	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
697281007920	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
697281007921	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
697281007922	feedback inhibition sensing region; other site
697281007923	homohexameric interface [polypeptide binding]; other site
697281007924	nucleotide binding site [chemical binding]; other site
697281007925	N-acetyl-L-glutamate binding site [chemical binding]; other site
697281007926	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
697281007927	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
697281007928	active site
697281007929	tetramer interface; other site
697281007930	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
697281007931	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
697281007932	DNA replication protein DnaC; Validated; Region: PRK06835
697281007933	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281007934	Walker A motif; other site
697281007935	ATP binding site [chemical binding]; other site
697281007936	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
697281007937	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
697281007938	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
697281007939	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
697281007940	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281007941	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007942	dimer interface [polypeptide binding]; other site
697281007943	conserved gate region; other site
697281007944	putative PBP binding loops; other site
697281007945	ABC-ATPase subunit interface; other site
697281007946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007947	dimer interface [polypeptide binding]; other site
697281007948	conserved gate region; other site
697281007949	putative PBP binding loops; other site
697281007950	ABC-ATPase subunit interface; other site
697281007951	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281007952	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281007953	transketolase; Reviewed; Region: PRK05899
697281007954	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
697281007955	TPP-binding site [chemical binding]; other site
697281007956	dimer interface [polypeptide binding]; other site
697281007957	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
697281007958	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
697281007959	PYR/PP interface [polypeptide binding]; other site
697281007960	dimer interface [polypeptide binding]; other site
697281007961	TPP binding site [chemical binding]; other site
697281007962	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
697281007963	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
697281007964	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
697281007965	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
697281007966	N- and C-terminal domain interface [polypeptide binding]; other site
697281007967	active site
697281007968	MgATP binding site [chemical binding]; other site
697281007969	catalytic site [active]
697281007970	metal binding site [ion binding]; metal-binding site
697281007971	glycerol binding site [chemical binding]; other site
697281007972	homotetramer interface [polypeptide binding]; other site
697281007973	homodimer interface [polypeptide binding]; other site
697281007974	protein IIAGlc interface [polypeptide binding]; other site
697281007975	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281007976	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281007977	DNA binding site [nucleotide binding]
697281007978	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281007979	ligand binding site [chemical binding]; other site
697281007980	dimerization interface [polypeptide binding]; other site
697281007981	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
697281007982	hexamer (dimer of trimers) interface [polypeptide binding]; other site
697281007983	substrate binding site [chemical binding]; other site
697281007984	trimer interface [polypeptide binding]; other site
697281007985	Mn binding site [ion binding]; other site
697281007986	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281007987	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
697281007988	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
697281007989	putative active site [active]
697281007990	putative catalytic site [active]
697281007991	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281007992	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007993	dimer interface [polypeptide binding]; other site
697281007994	conserved gate region; other site
697281007995	putative PBP binding loops; other site
697281007996	ABC-ATPase subunit interface; other site
697281007997	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
697281007998	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281007999	dimer interface [polypeptide binding]; other site
697281008000	conserved gate region; other site
697281008001	putative PBP binding loops; other site
697281008002	ABC-ATPase subunit interface; other site
697281008003	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281008004	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281008005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281008006	Response regulator receiver domain; Region: Response_reg; pfam00072
697281008007	active site
697281008008	phosphorylation site [posttranslational modification]
697281008009	intermolecular recognition site; other site
697281008010	dimerization interface [polypeptide binding]; other site
697281008011	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008012	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281008013	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008014	HAMP domain; Region: HAMP; pfam00672
697281008015	Histidine kinase; Region: His_kinase; pfam06580
697281008016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281008017	Mg2+ binding site [ion binding]; other site
697281008018	G-X-G motif; other site
697281008019	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
697281008020	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
697281008021	active site
697281008022	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
697281008023	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
697281008024	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
697281008025	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
697281008026	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
697281008027	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
697281008028	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281008029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008030	dimer interface [polypeptide binding]; other site
697281008031	conserved gate region; other site
697281008032	putative PBP binding loops; other site
697281008033	ABC-ATPase subunit interface; other site
697281008034	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281008035	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008036	dimer interface [polypeptide binding]; other site
697281008037	conserved gate region; other site
697281008038	putative PBP binding loops; other site
697281008039	ABC-ATPase subunit interface; other site
697281008040	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281008041	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281008042	Response regulator receiver domain; Region: Response_reg; pfam00072
697281008043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281008044	active site
697281008045	phosphorylation site [posttranslational modification]
697281008046	intermolecular recognition site; other site
697281008047	dimerization interface [polypeptide binding]; other site
697281008048	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008049	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281008050	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008051	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281008052	dimerization interface [polypeptide binding]; other site
697281008053	Histidine kinase; Region: His_kinase; pfam06580
697281008054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281008055	ATP binding site [chemical binding]; other site
697281008056	Mg2+ binding site [ion binding]; other site
697281008057	G-X-G motif; other site
697281008058	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
697281008059	replicative DNA helicase; Region: DnaB; TIGR00665
697281008060	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
697281008061	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
697281008062	Walker A motif; other site
697281008063	ATP binding site [chemical binding]; other site
697281008064	Walker B motif; other site
697281008065	DNA binding loops [nucleotide binding]
697281008066	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
697281008067	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
697281008068	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
697281008069	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
697281008070	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
697281008071	DHH family; Region: DHH; pfam01368
697281008072	DHHA1 domain; Region: DHHA1; pfam02272
697281008073	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
697281008074	prephenate dehydratase; Provisional; Region: PRK11898
697281008075	Prephenate dehydratase; Region: PDT; pfam00800
697281008076	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
697281008077	putative L-Phe binding site [chemical binding]; other site
697281008078	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
697281008079	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
697281008080	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
697281008081	dimer interface [polypeptide binding]; other site
697281008082	ssDNA binding site [nucleotide binding]; other site
697281008083	tetramer (dimer of dimers) interface [polypeptide binding]; other site
697281008084	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
697281008085	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
697281008086	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
697281008087	SurA N-terminal domain; Region: SurA_N_3; cl07813
697281008088	Transposase; Region: HTH_Tnp_1; cl17663
697281008089	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
697281008090	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
697281008091	Walker A/P-loop; other site
697281008092	ATP binding site [chemical binding]; other site
697281008093	Q-loop/lid; other site
697281008094	ABC transporter signature motif; other site
697281008095	Walker B; other site
697281008096	D-loop; other site
697281008097	H-loop/switch region; other site
697281008098	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
697281008099	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
697281008100	Walker A/P-loop; other site
697281008101	ATP binding site [chemical binding]; other site
697281008102	Q-loop/lid; other site
697281008103	ABC transporter signature motif; other site
697281008104	Walker B; other site
697281008105	D-loop; other site
697281008106	H-loop/switch region; other site
697281008107	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
697281008108	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
697281008109	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281008110	DNA binding residues [nucleotide binding]
697281008111	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
697281008112	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281008113	Walker A/P-loop; other site
697281008114	ATP binding site [chemical binding]; other site
697281008115	Q-loop/lid; other site
697281008116	ABC transporter signature motif; other site
697281008117	Walker B; other site
697281008118	D-loop; other site
697281008119	H-loop/switch region; other site
697281008120	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
697281008121	VanW like protein; Region: VanW; pfam04294
697281008122	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
697281008123	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
697281008124	stage II sporulation protein E; Region: spore_II_E; TIGR02865
697281008125	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
697281008126	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
697281008127	acyl-activating enzyme (AAE) consensus motif; other site
697281008128	AMP binding site [chemical binding]; other site
697281008129	active site
697281008130	CoA binding site [chemical binding]; other site
697281008131	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
697281008132	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
697281008133	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
697281008134	dimer interface [polypeptide binding]; other site
697281008135	PYR/PP interface [polypeptide binding]; other site
697281008136	TPP binding site [chemical binding]; other site
697281008137	substrate binding site [chemical binding]; other site
697281008138	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
697281008139	TPP-binding site; other site
697281008140	4Fe-4S binding domain; Region: Fer4; pfam00037
697281008141	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
697281008142	putative CheA interaction surface; other site
697281008143	peptide chain release factor 2; Validated; Region: prfB; PRK00578
697281008144	PCRF domain; Region: PCRF; pfam03462
697281008145	RF-1 domain; Region: RF-1; pfam00472
697281008146	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
697281008147	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
697281008148	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
697281008149	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
697281008150	nucleotide binding region [chemical binding]; other site
697281008151	ATP-binding site [chemical binding]; other site
697281008152	SEC-C motif; Region: SEC-C; pfam02810
697281008153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
697281008154	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
697281008155	putative substrate translocation pore; other site
697281008156	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281008157	dimerization interface [polypeptide binding]; other site
697281008158	putative DNA binding site [nucleotide binding]; other site
697281008159	putative Zn2+ binding site [ion binding]; other site
697281008160	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
697281008161	Predicted integral membrane protein [Function unknown]; Region: COG5658
697281008162	SdpI/YhfL protein family; Region: SdpI; pfam13630
697281008163	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
697281008164	active site
697281008165	catalytic triad [active]
697281008166	oxyanion hole [active]
697281008167	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
697281008168	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
697281008169	Predicted membrane protein [Function unknown]; Region: COG4392
697281008170	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
697281008171	Membrane protein of unknown function; Region: DUF360; pfam04020
697281008172	putative alpha-glucosidase; Provisional; Region: PRK10658
697281008173	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
697281008174	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
697281008175	active site
697281008176	homotrimer interface [polypeptide binding]; other site
697281008177	catalytic site [active]
697281008178	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
697281008179	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281008180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008181	dimer interface [polypeptide binding]; other site
697281008182	ABC-ATPase subunit interface; other site
697281008183	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281008184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008185	dimer interface [polypeptide binding]; other site
697281008186	conserved gate region; other site
697281008187	putative PBP binding loops; other site
697281008188	ABC-ATPase subunit interface; other site
697281008189	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
697281008190	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281008191	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
697281008192	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281008193	active site
697281008194	phosphorylation site [posttranslational modification]
697281008195	intermolecular recognition site; other site
697281008196	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008197	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281008198	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008199	Histidine kinase; Region: His_kinase; pfam06580
697281008200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281008201	ATP binding site [chemical binding]; other site
697281008202	Mg2+ binding site [ion binding]; other site
697281008203	G-X-G motif; other site
697281008204	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281008205	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281008206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008207	dimer interface [polypeptide binding]; other site
697281008208	conserved gate region; other site
697281008209	putative PBP binding loops; other site
697281008210	ABC-ATPase subunit interface; other site
697281008211	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281008212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008213	dimer interface [polypeptide binding]; other site
697281008214	conserved gate region; other site
697281008215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
697281008216	ABC-ATPase subunit interface; other site
697281008217	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281008218	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
697281008219	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281008220	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
697281008221	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
697281008222	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
697281008223	catalytic site [active]
697281008224	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
697281008225	Histidine kinase; Region: His_kinase; pfam06580
697281008226	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281008227	ATP binding site [chemical binding]; other site
697281008228	Mg2+ binding site [ion binding]; other site
697281008229	G-X-G motif; other site
697281008230	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
697281008231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281008232	active site
697281008233	phosphorylation site [posttranslational modification]
697281008234	intermolecular recognition site; other site
697281008235	dimerization interface [polypeptide binding]; other site
697281008236	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008237	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008238	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
697281008239	Right handed beta helix region; Region: Beta_helix; pfam13229
697281008240	Right handed beta helix region; Region: Beta_helix; pfam13229
697281008241	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
697281008242	ligand binding site [chemical binding]; other site
697281008243	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
697281008244	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
697281008245	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
697281008246	Right handed beta helix region; Region: Beta_helix; pfam13229
697281008247	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
697281008248	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
697281008249	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
697281008250	Melibiase; Region: Melibiase; pfam02065
697281008251	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281008252	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
697281008253	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
697281008254	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
697281008255	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
697281008256	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281008257	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
697281008258	Right handed beta helix region; Region: Beta_helix; pfam13229
697281008259	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
697281008260	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
697281008261	ligand binding site [chemical binding]; other site
697281008262	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281008263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008264	dimer interface [polypeptide binding]; other site
697281008265	conserved gate region; other site
697281008266	putative PBP binding loops; other site
697281008267	ABC-ATPase subunit interface; other site
697281008268	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281008269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008270	dimer interface [polypeptide binding]; other site
697281008271	conserved gate region; other site
697281008272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
697281008273	ABC-ATPase subunit interface; other site
697281008274	Histidine kinase; Region: His_kinase; pfam06580
697281008275	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281008276	ATP binding site [chemical binding]; other site
697281008277	Mg2+ binding site [ion binding]; other site
697281008278	G-X-G motif; other site
697281008279	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281008280	Response regulator receiver domain; Region: Response_reg; pfam00072
697281008281	active site
697281008282	phosphorylation site [posttranslational modification]
697281008283	intermolecular recognition site; other site
697281008284	dimerization interface [polypeptide binding]; other site
697281008285	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281008286	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008287	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
697281008288	active site
697281008289	catalytic residues [active]
697281008290	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281008291	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
697281008292	hexamer (dimer of trimers) interface [polypeptide binding]; other site
697281008293	trimer interface [polypeptide binding]; other site
697281008294	substrate binding site [chemical binding]; other site
697281008295	Mn binding site [ion binding]; other site
697281008296	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281008297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008298	dimer interface [polypeptide binding]; other site
697281008299	conserved gate region; other site
697281008300	putative PBP binding loops; other site
697281008301	ABC-ATPase subunit interface; other site
697281008302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008303	dimer interface [polypeptide binding]; other site
697281008304	conserved gate region; other site
697281008305	putative PBP binding loops; other site
697281008306	ABC-ATPase subunit interface; other site
697281008307	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281008308	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281008309	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
697281008310	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
697281008311	AP (apurinic/apyrimidinic) site pocket; other site
697281008312	DNA interaction; other site
697281008313	Metal-binding active site; metal-binding site
697281008314	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
697281008315	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
697281008316	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
697281008317	NAD(P) binding site [chemical binding]; other site
697281008318	catalytic residues [active]
697281008319	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
697281008320	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
697281008321	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
697281008322	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
697281008323	intersubunit interface [polypeptide binding]; other site
697281008324	active site
697281008325	zinc binding site [ion binding]; other site
697281008326	Na+ binding site [ion binding]; other site
697281008327	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281008328	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281008329	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281008330	Predicted membrane protein [Function unknown]; Region: COG2855
697281008331	alpha-galactosidase; Provisional; Region: PRK15076
697281008332	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
697281008333	NAD binding site [chemical binding]; other site
697281008334	sugar binding site [chemical binding]; other site
697281008335	divalent metal binding site [ion binding]; other site
697281008336	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
697281008337	dimer interface [polypeptide binding]; other site
697281008338	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
697281008339	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
697281008340	nucleotide binding site [chemical binding]; other site
697281008341	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
697281008342	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
697281008343	Walker A/P-loop; other site
697281008344	ATP binding site [chemical binding]; other site
697281008345	Q-loop/lid; other site
697281008346	ABC transporter signature motif; other site
697281008347	Walker B; other site
697281008348	D-loop; other site
697281008349	H-loop/switch region; other site
697281008350	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
697281008351	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
697281008352	putative substrate binding site [chemical binding]; other site
697281008353	putative ATP binding site [chemical binding]; other site
697281008354	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
697281008355	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
697281008356	substrate binding site [chemical binding]; other site
697281008357	dimer interface [polypeptide binding]; other site
697281008358	ATP binding site [chemical binding]; other site
697281008359	Protein of unknown function (DUF554); Region: DUF554; pfam04474
697281008360	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
697281008361	30S subunit binding site; other site
697281008362	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
697281008363	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
697281008364	Walker A/P-loop; other site
697281008365	ATP binding site [chemical binding]; other site
697281008366	Q-loop/lid; other site
697281008367	ABC transporter signature motif; other site
697281008368	Walker B; other site
697281008369	D-loop; other site
697281008370	H-loop/switch region; other site
697281008371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008372	dimer interface [polypeptide binding]; other site
697281008373	conserved gate region; other site
697281008374	putative PBP binding loops; other site
697281008375	ABC-ATPase subunit interface; other site
697281008376	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
697281008377	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
697281008378	substrate binding pocket [chemical binding]; other site
697281008379	membrane-bound complex binding site; other site
697281008380	hinge residues; other site
697281008381	Probable zinc-binding domain; Region: zf-trcl; pfam13451
697281008382	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
697281008383	The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465
697281008384	prolyl-tRNA synthetase; Provisional; Region: PRK09194
697281008385	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
697281008386	dimer interface [polypeptide binding]; other site
697281008387	motif 1; other site
697281008388	active site
697281008389	motif 2; other site
697281008390	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
697281008391	putative deacylase active site [active]
697281008392	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
697281008393	active site
697281008394	motif 3; other site
697281008395	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
697281008396	anticodon binding site; other site
697281008397	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
697281008398	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
697281008399	Flagellar protein FliS; Region: FliS; cl00654
697281008400	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
697281008401	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
697281008402	putative ligand binding site [chemical binding]; other site
697281008403	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
697281008404	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
697281008405	TM-ABC transporter signature motif; other site
697281008406	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
697281008407	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
697281008408	Walker A/P-loop; other site
697281008409	ATP binding site [chemical binding]; other site
697281008410	Q-loop/lid; other site
697281008411	ABC transporter signature motif; other site
697281008412	Walker B; other site
697281008413	D-loop; other site
697281008414	H-loop/switch region; other site
697281008415	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
697281008416	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
697281008417	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281008418	Walker A/P-loop; other site
697281008419	ATP binding site [chemical binding]; other site
697281008420	Q-loop/lid; other site
697281008421	ABC transporter signature motif; other site
697281008422	Walker B; other site
697281008423	D-loop; other site
697281008424	H-loop/switch region; other site
697281008425	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
697281008426	Q-loop/lid; other site
697281008427	Walker B; other site
697281008428	D-loop; other site
697281008429	H-loop/switch region; other site
697281008430	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
697281008431	Histidine kinase; Region: His_kinase; pfam06580
697281008432	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281008433	ATP binding site [chemical binding]; other site
697281008434	Mg2+ binding site [ion binding]; other site
697281008435	G-X-G motif; other site
697281008436	Response regulator receiver domain; Region: Response_reg; pfam00072
697281008437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281008438	active site
697281008439	phosphorylation site [posttranslational modification]
697281008440	intermolecular recognition site; other site
697281008441	dimerization interface [polypeptide binding]; other site
697281008442	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008443	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281008444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008445	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
697281008446	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
697281008447	tetrameric interface [polypeptide binding]; other site
697281008448	NAD binding site [chemical binding]; other site
697281008449	catalytic residues [active]
697281008450	KduI/IolB family; Region: KduI; pfam04962
697281008451	Transaldolase; Region: Transaldolase; pfam00923
697281008452	catalytic residue [active]
697281008453	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
697281008454	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
697281008455	Metal-binding active site; metal-binding site
697281008456	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
697281008457	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
697281008458	PYR/PP interface [polypeptide binding]; other site
697281008459	dimer interface [polypeptide binding]; other site
697281008460	TPP binding site [chemical binding]; other site
697281008461	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
697281008462	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
697281008463	TPP-binding site; other site
697281008464	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
697281008465	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
697281008466	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
697281008467	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281008468	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
697281008469	DNA binding site [nucleotide binding]
697281008470	domain linker motif; other site
697281008471	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281008472	dimerization interface [polypeptide binding]; other site
697281008473	ligand binding site [chemical binding]; other site
697281008474	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
697281008475	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281008476	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281008477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008478	dimer interface [polypeptide binding]; other site
697281008479	conserved gate region; other site
697281008480	putative PBP binding loops; other site
697281008481	ABC-ATPase subunit interface; other site
697281008482	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281008483	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008484	dimer interface [polypeptide binding]; other site
697281008485	conserved gate region; other site
697281008486	ABC-ATPase subunit interface; other site
697281008487	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
697281008488	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
697281008489	DNA-binding site [nucleotide binding]; DNA binding site
697281008490	FCD domain; Region: FCD; pfam07729
697281008491	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
697281008492	Uncharacterized conserved protein [Function unknown]; Region: COG2006
697281008493	4Fe-4S binding domain; Region: Fer4; pfam00037
697281008494	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
697281008495	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
697281008496	NAD(P) binding site [chemical binding]; other site
697281008497	active site
697281008498	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
697281008499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
697281008500	MFS/sugar transport protein; Region: MFS_2; pfam13347
697281008501	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
697281008502	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
697281008503	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
697281008504	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281008505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008506	dimer interface [polypeptide binding]; other site
697281008507	conserved gate region; other site
697281008508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
697281008509	ABC-ATPase subunit interface; other site
697281008510	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281008511	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008512	dimer interface [polypeptide binding]; other site
697281008513	conserved gate region; other site
697281008514	ABC-ATPase subunit interface; other site
697281008515	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281008516	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281008517	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
697281008518	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
697281008519	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
697281008520	dimer interface [polypeptide binding]; other site
697281008521	active site
697281008522	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
697281008523	dimer interface [polypeptide binding]; other site
697281008524	active site
697281008525	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
697281008526	alpha-galactosidase; Provisional; Region: PRK15076
697281008527	NAD(P) binding site [chemical binding]; other site
697281008528	LDH/MDH dimer interface [polypeptide binding]; other site
697281008529	substrate binding site [chemical binding]; other site
697281008530	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
697281008531	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
697281008532	ATP binding site [chemical binding]; other site
697281008533	substrate binding site [chemical binding]; other site
697281008534	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
697281008535	non-specific DNA interactions [nucleotide binding]; other site
697281008536	DNA binding site [nucleotide binding]
697281008537	sequence specific DNA binding site [nucleotide binding]; other site
697281008538	putative cAMP binding site [chemical binding]; other site
697281008539	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
697281008540	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
697281008541	nucleotide binding site [chemical binding]; other site
697281008542	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
697281008543	active site
697281008544	catalytic motif [active]
697281008545	Zn binding site [ion binding]; other site
697281008546	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
697281008547	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
697281008548	substrate binding site [chemical binding]; other site
697281008549	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
697281008550	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
697281008551	substrate binding site [chemical binding]; other site
697281008552	ligand binding site [chemical binding]; other site
697281008553	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
697281008554	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
697281008555	active site
697281008556	catalytic residues [active]
697281008557	metal binding site [ion binding]; metal-binding site
697281008558	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
697281008559	2-isopropylmalate synthase; Validated; Region: PRK00915
697281008560	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
697281008561	active site
697281008562	catalytic residues [active]
697281008563	metal binding site [ion binding]; metal-binding site
697281008564	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
697281008565	ketol-acid reductoisomerase; Provisional; Region: PRK05479
697281008566	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
697281008567	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
697281008568	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
697281008569	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
697281008570	putative valine binding site [chemical binding]; other site
697281008571	dimer interface [polypeptide binding]; other site
697281008572	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
697281008573	Helix-turn-helix domain; Region: HTH_28; pfam13518
697281008574	Winged helix-turn helix; Region: HTH_29; pfam13551
697281008575	Integrase core domain; Region: rve; pfam00665
697281008576	Integrase core domain; Region: rve_3; cl15866
697281008577	Cache domain; Region: Cache_1; pfam02743
697281008578	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
697281008579	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
697281008580	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
697281008581	dimer interface [polypeptide binding]; other site
697281008582	putative CheW interface [polypeptide binding]; other site
697281008583	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
697281008584	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
697281008585	DNA binding residues [nucleotide binding]
697281008586	putative dimer interface [polypeptide binding]; other site
697281008587	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
697281008588	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
697281008589	active site
697281008590	catalytic tetrad [active]
697281008591	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
697281008592	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185
697281008593	putative active site [active]
697281008594	metal binding site [ion binding]; metal-binding site
697281008595	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
697281008596	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
697281008597	Flavin Reductases; Region: FlaRed; cl00801
697281008598	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281008599	dimerization interface [polypeptide binding]; other site
697281008600	putative DNA binding site [nucleotide binding]; other site
697281008601	putative Zn2+ binding site [ion binding]; other site
697281008602	Predicted permeases [General function prediction only]; Region: COG0701
697281008603	Ferredoxin [Energy production and conversion]; Region: COG1146
697281008604	Domain of unknown function (DUF2703); Region: DUF2703; pfam10865
697281008605	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
697281008606	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
697281008607	lipoprotein signal peptidase; Provisional; Region: PRK14786
697281008608	lipoprotein signal peptidase; Provisional; Region: PRK14787
697281008609	Heavy-metal-associated domain; Region: HMA; pfam00403
697281008610	metal-binding site [ion binding]
697281008611	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
697281008612	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
697281008613	metal-binding site [ion binding]
697281008614	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
697281008615	Soluble P-type ATPase [General function prediction only]; Region: COG4087
697281008616	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
697281008617	dimerization interface [polypeptide binding]; other site
697281008618	putative DNA binding site [nucleotide binding]; other site
697281008619	putative Zn2+ binding site [ion binding]; other site
697281008620	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
697281008621	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
697281008622	catalytic residues [active]
697281008623	catalytic nucleophile [active]
697281008624	Recombinase; Region: Recombinase; pfam07508
697281008625	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
697281008626	Recombinase; Region: Recombinase; pfam07508
697281008627	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
697281008628	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
697281008629	catalytic residues [active]
697281008630	catalytic nucleophile [active]
697281008631	Recombinase; Region: Recombinase; pfam07508
697281008632	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
697281008633	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
697281008634	amidase catalytic site [active]
697281008635	Zn binding residues [ion binding]; other site
697281008636	substrate binding site [chemical binding]; other site
697281008637	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
697281008638	Holin family; Region: Phage_holin_4; pfam05105
697281008639	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
697281008640	active site
697281008641	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
697281008642	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
697281008643	Phage tail protein; Region: Sipho_tail; pfam05709
697281008644	Phage-related minor tail protein [Function unknown]; Region: COG5280
697281008645	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
697281008646	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
697281008647	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
697281008648	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
697281008649	oligomerization interface [polypeptide binding]; other site
697281008650	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
697281008651	Phage capsid family; Region: Phage_capsid; pfam05065
697281008652	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
697281008653	oligomer interface [polypeptide binding]; other site
697281008654	active site residues [active]
697281008655	Phage-related protein [Function unknown]; Region: COG4695
697281008656	Phage portal protein; Region: Phage_portal; pfam04860
697281008657	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
697281008658	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
697281008659	putative active site pocket [active]
697281008660	dimerization interface [polypeptide binding]; other site
697281008661	putative catalytic residue [active]
697281008662	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
697281008663	Domain of unknown function (DUF4314); Region: DUF4314; pfam14192
697281008664	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
697281008665	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
697281008666	ParB-like nuclease domain; Region: ParB; smart00470
697281008667	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
697281008668	DNA methylase; Region: N6_N4_Mtase; pfam01555
697281008669	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
697281008670	ParB-like nuclease domain; Region: ParB; smart00470
697281008671	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
697281008672	DNA methylase; Region: N6_N4_Mtase; pfam01555
697281008673	Phage terminase, small subunit; Region: Terminase_4; cl01525
697281008674	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
697281008675	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
697281008676	active site
697281008677	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
697281008678	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
697281008679	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
697281008680	ATP binding site [chemical binding]; other site
697281008681	putative Mg++ binding site [ion binding]; other site
697281008682	VRR-NUC domain; Region: VRR_NUC; pfam08774
697281008683	Virulence-associated protein E; Region: VirE; pfam05272
697281008684	Prophage antirepressor [Transcription]; Region: COG3617
697281008685	BRO family, N-terminal domain; Region: Bro-N; smart01040
697281008686	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
697281008687	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
697281008688	active site
697281008689	substrate binding site [chemical binding]; other site
697281008690	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
697281008691	active site
697281008692	DNA binding site [nucleotide binding]
697281008693	catalytic site [active]
697281008694	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
697281008695	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
697281008696	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
697281008697	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281008698	DNA binding residues [nucleotide binding]
697281008699	Protein of unknown function DUF45; Region: DUF45; pfam01863
697281008700	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
697281008701	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
697281008702	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
697281008703	ATP binding site [chemical binding]; other site
697281008704	putative Mg++ binding site [ion binding]; other site
697281008705	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
697281008706	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
697281008707	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
697281008708	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
697281008709	HsdM N-terminal domain; Region: HsdM_N; pfam12161
697281008710	Methyltransferase domain; Region: Methyltransf_26; pfam13659
697281008711	Helix-turn-helix domain; Region: HTH_17; pfam12728
697281008712	TRAM domain; Region: TRAM; cl01282
697281008713	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
697281008714	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
697281008715	S-adenosylmethionine binding site [chemical binding]; other site
697281008716	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
697281008717	Peptidase family U32; Region: Peptidase_U32; pfam01136
697281008718	Collagenase; Region: DUF3656; pfam12392
697281008719	Peptidase family U32; Region: Peptidase_U32; pfam01136
697281008720	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281008721	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
697281008722	DNA-binding site [nucleotide binding]; DNA binding site
697281008723	Transcriptional regulators [Transcription]; Region: PurR; COG1609
697281008724	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
697281008725	ligand binding site [chemical binding]; other site
697281008726	dimerization interface [polypeptide binding]; other site
697281008727	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281008728	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
697281008729	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
697281008730	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
697281008731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281008732	active site
697281008733	phosphorylation site [posttranslational modification]
697281008734	intermolecular recognition site; other site
697281008735	dimerization interface [polypeptide binding]; other site
697281008736	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
697281008737	DNA binding site [nucleotide binding]
697281008738	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
697281008739	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
697281008740	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
697281008741	dimer interface [polypeptide binding]; other site
697281008742	phosphorylation site [posttranslational modification]
697281008743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281008744	ATP binding site [chemical binding]; other site
697281008745	Mg2+ binding site [ion binding]; other site
697281008746	G-X-G motif; other site
697281008747	Tetratricopeptide repeat; Region: TPR_16; pfam13432
697281008748	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
697281008749	TPR motif; other site
697281008750	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
697281008751	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
697281008752	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
697281008753	TrkA-N domain; Region: TrkA_N; pfam02254
697281008754	TrkA-C domain; Region: TrkA_C; pfam02080
697281008755	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
697281008756	TrkA-N domain; Region: TrkA_N; pfam02254
697281008757	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752
697281008758	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
697281008759	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
697281008760	ATP binding site [chemical binding]; other site
697281008761	putative Mg++ binding site [ion binding]; other site
697281008762	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
697281008763	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
697281008764	nucleotide binding region [chemical binding]; other site
697281008765	ATP-binding site [chemical binding]; other site
697281008766	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
697281008767	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
697281008768	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
697281008769	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
697281008770	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
697281008771	Protein of unknown function (DUF499); Region: DUF499; pfam04465
697281008772	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
697281008773	active site
697281008774	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
697281008775	Helix-turn-helix domain; Region: HTH_17; pfam12728
697281008776	Replication-relaxation; Region: Replic_Relax; pfam13814
697281008777	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
697281008778	AAA-like domain; Region: AAA_10; pfam12846
697281008779	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
697281008780	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
697281008781	polymerase nucleotide-binding site; other site
697281008782	DNA-binding residues [nucleotide binding]; DNA binding site
697281008783	nucleotide binding site [chemical binding]; other site
697281008784	primase nucleotide-binding site [nucleotide binding]; other site
697281008785	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
697281008786	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
697281008787	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
697281008788	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
697281008789	Int/Topo IB signature motif; other site
697281008790	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
697281008791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
697281008792	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
697281008793	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
697281008794	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
697281008795	active site
697281008796	metal binding site [ion binding]; metal-binding site
697281008797	Sporulation related domain; Region: SPOR; pfam05036
697281008798	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
697281008799	active site
697281008800	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
697281008801	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
697281008802	Phage tail protein; Region: Sipho_tail; pfam05709
697281008803	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
697281008804	membrane protein P6; Region: PHA01399
697281008805	Phage major tail protein 2; Region: Phage_tail_2; cl11463
697281008806	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
697281008807	phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725
697281008808	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
697281008809	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
697281008810	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
697281008811	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
697281008812	oligomerization interface [polypeptide binding]; other site
697281008813	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
697281008814	Phage capsid family; Region: Phage_capsid; pfam05065
697281008815	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
697281008816	Src Homology 3 domain superfamily; Region: SH3; cl17036
697281008817	peptide ligand binding site [polypeptide binding]; other site
697281008818	Phage-related protein [Function unknown]; Region: COG4695
697281008819	Phage portal protein; Region: Phage_portal; pfam04860
697281008820	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
697281008821	Phage terminase, small subunit; Region: Terminase_4; pfam05119
697281008822	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
697281008823	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
697281008824	active site
697281008825	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
697281008826	DNA binding residues [nucleotide binding]
697281008827	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
697281008828	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
697281008829	Walker A motif; other site
697281008830	ATP binding site [chemical binding]; other site
697281008831	Walker B motif; other site
697281008832	arginine finger; other site
697281008833	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
697281008834	Helix-turn-helix domain; Region: HTH_17; pfam12728
697281008835	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281008836	non-specific DNA binding site [nucleotide binding]; other site
697281008837	salt bridge; other site
697281008838	sequence-specific DNA binding site [nucleotide binding]; other site
697281008839	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
697281008840	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
697281008841	non-specific DNA binding site [nucleotide binding]; other site
697281008842	salt bridge; other site
697281008843	sequence-specific DNA binding site [nucleotide binding]; other site
697281008844	Domain of unknown function (DUF955); Region: DUF955; cl01076
697281008845	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
697281008846	active site
697281008847	catalytic site [active]
697281008848	substrate binding site [chemical binding]; other site
697281008849	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
697281008850	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
697281008851	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
697281008852	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
697281008853	Int/Topo IB signature motif; other site
697281008854	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008855	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281008856	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008857	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281008858	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
697281008859	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281008860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008861	dimer interface [polypeptide binding]; other site
697281008862	ABC-ATPase subunit interface; other site
697281008863	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281008864	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008865	dimer interface [polypeptide binding]; other site
697281008866	conserved gate region; other site
697281008867	ABC-ATPase subunit interface; other site
697281008868	mannonate dehydratase; Region: uxuA; TIGR00695
697281008869	mannonate dehydratase; Provisional; Region: PRK03906
697281008870	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
697281008871	Colicin V production protein; Region: Colicin_V; pfam02674
697281008872	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281008873	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
697281008874	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008875	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281008876	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008877	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
697281008878	ParB-like nuclease domain; Region: ParB; smart00470
697281008879	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
697281008880	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
697281008881	P-loop; other site
697281008882	Magnesium ion binding site [ion binding]; other site
697281008883	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
697281008884	Magnesium ion binding site [ion binding]; other site
697281008885	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
697281008886	ParB-like nuclease domain; Region: ParB; smart00470
697281008887	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
697281008888	active site
697281008889	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
697281008890	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
697281008891	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
697281008892	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
697281008893	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
697281008894	substrate binding pocket [chemical binding]; other site
697281008895	chain length determination region; other site
697281008896	substrate-Mg2+ binding site; other site
697281008897	catalytic residues [active]
697281008898	aspartate-rich region 1; other site
697281008899	active site lid residues [active]
697281008900	aspartate-rich region 2; other site
697281008901	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
697281008902	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
697281008903	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
697281008904	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
697281008905	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
697281008906	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
697281008907	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
697281008908	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
697281008909	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
697281008910	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
697281008911	trmE is a tRNA modification GTPase; Region: trmE; cd04164
697281008912	G1 box; other site
697281008913	GTP/Mg2+ binding site [chemical binding]; other site
697281008914	Switch I region; other site
697281008915	G2 box; other site
697281008916	Switch II region; other site
697281008917	G3 box; other site
697281008918	G4 box; other site
697281008919	G5 box; other site
697281008920	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
697281008921	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
697281008922	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
697281008923	G-X-X-G motif; other site
697281008924	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
697281008925	RxxxH motif; other site
697281008926	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
697281008927	Haemolytic domain; Region: Haemolytic; pfam01809
697281008928	ribonuclease P; Reviewed; Region: rnpA; PRK00499
697281008929	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
697281008930	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
697281008931	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
697281008932	Melibiase; Region: Melibiase; pfam02065
697281008933	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
697281008934	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
697281008935	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008936	dimer interface [polypeptide binding]; other site
697281008937	conserved gate region; other site
697281008938	ABC-ATPase subunit interface; other site
697281008939	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
697281008940	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
697281008941	dimer interface [polypeptide binding]; other site
697281008942	conserved gate region; other site
697281008943	ABC-ATPase subunit interface; other site
697281008944	Response regulator receiver domain; Region: Response_reg; pfam00072
697281008945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
697281008946	active site
697281008947	phosphorylation site [posttranslational modification]
697281008948	intermolecular recognition site; other site
697281008949	dimerization interface [polypeptide binding]; other site
697281008950	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
697281008951	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
697281008952	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
697281008953	dimerization interface [polypeptide binding]; other site
697281008954	Histidine kinase; Region: His_kinase; pfam06580
697281008955	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
697281008956	ATP binding site [chemical binding]; other site
697281008957	Mg2+ binding site [ion binding]; other site
697281008958	G-X-G motif; other site