-- dump date 20140619_135504 -- class Genbank::CDS -- table cds_note -- id note YP_087195.1 Uncharacterized membrane protein YP_087196.1 Lysophospholipase YP_087198.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_087199.2 putative ABC transporter, membrane protein YP_087200.1 Predicted ATPase involved in cell division YP_087203.1 Predicted flavoprotein YP_087205.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_087206.1 Aspartate racemase YP_087207.1 catalyzes the formation of 6-phospho-D-gluconate from 6-phospho-D-glucono-1,5-lactone YP_087208.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_087209.1 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase YP_087210.1 Uncharacterized membrane protein YP_087211.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_087212.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_087213.1 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) YP_087214.2 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_087215.2 Predicted Zn-dependent hydrolases of the beta-lactamase fold YP_087216.1 negative regulator of ulaG and ulaABCDEF YP_087217.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_087218.1 Tellurite resistance protein and related permeases YP_087220.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_087222.1 Na+/glutamate symporter YP_087223.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_087224.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_087225.1 Uncharacterized BCR YP_087226.1 Predicted ATPase YP_087227.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_087228.1 catalyzes the formation of asparagine from aspartate and ammonia YP_087230.1 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit YP_087231.1 catalyzes the formation of pyruvate from oxaloacetate YP_087232.1 catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide YP_087233.1 Predicted Rossmann-fold nucleotide-binding protein involved in DNA uptake YP_087236.2 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_087237.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_087238.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_087239.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate YP_087240.1 Sugar (pentulose and hexulose) kinases YP_087241.1 Dicarboxylate-binding periplasmic protein YP_087242.1 Dicarboxylate-binding periplasmic protein YP_087243.1 Integral membrane protein, possible transporter YP_087244.1 Uncharacterized BCR YP_087245.1 Uncharacterized BCR YP_087246.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate YP_087247.1 Transcriptional regulator YP_087248.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_087249.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_087250.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_087251.1 Sugar (pentulose and hexulose) kinases YP_087252.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose YP_087253.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_087254.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_087255.1 Periplasmic sugar-binding proteins YP_087256.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_087257.1 Uncharacterized BCR YP_087258.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_087259.1 Dihydrodipicolinate synthase/N-acetylneuraminate lyase YP_087260.1 Phosphoglycerate dehydrogenase and related dehydrogenases YP_087261.1 Alcohol dehydrogenase IV YP_087264.1 Uncharacterized BCR YP_087266.1 Transcriptional regulators of sugar metabolism YP_087276.1 Phage protein D YP_087284.1 Phage tail sheath protein FI YP_087304.1 Predicted transcriptional regulators YP_087313.1 General secretion pathway protein A YP_087322.1 Uncharacterized BCR YP_087323.1 Zn-finger domain associated with topoisomerase type I YP_087324.1 Putative translation factor (SUA5) YP_087325.1 catalyzes the formation of shikimate from 3-dehydroshikimate in aromatic amino acid biosynthesis YP_087327.1 ATP/ADP translocase YP_087328.1 NhaP-type Na+/H+ and K+/H+ antiporters YP_087329.1 ATPase components of ABC transporters with duplicated ATPase domains YP_087330.1 Integral membrane proteins of the MarC family YP_087331.1 N6-adenine-specific methylase YP_087332.1 Signal recognition particle GTPase YP_087333.1 Uncharacterized ACR YP_087334.1 Predicted nucleoside-diphosphate-sugar epimerases YP_087335.1 Predicted transcriptional regulators YP_087336.1 Membrane transporters of cations and cationic drugs YP_087337.1 Predicted esterase of the alpha-beta hydrolase superfamily YP_087338.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_087340.1 Transcriptional regulators YP_087341.1 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) YP_087342.1 Phosphotransferase system component IIB of unknown specificity YP_087343.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_087344.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_087345.2 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_087346.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA YP_087347.1 Peroxiredoxin YP_087348.2 Uncharacterized BCR YP_087349.1 FKBP-type peptidyl-prolyl cis-trans isomerases 1 YP_087350.1 Uncharacterized BCR YP_087351.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_087352.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_087354.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_087355.2 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_087356.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_087357.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_087358.1 Predicted rRNA methylase (SpoU class) YP_087361.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_087364.1 DHBP synthase; functions during riboflavin biosynthesis YP_087365.2 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs YP_087366.1 Uncharacterized ACR YP_087367.1 Trk-type K+ transport systems, membrane components YP_087368.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX YP_087371.1 Predicted transcriptional regulators YP_087372.1 Uncharacterized ACR, similar to gamma-carboxymuconolactone decarboxylase subunit YP_087373.1 NADH dehydrogenase, FAD-containing subunit YP_087374.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_087375.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_087376.1 Uncharacterized BCR YP_087377.1 Bacterial nucleoid DNA-binding protein YP_087379.1 Transcriptional regulators of sugar metabolism YP_087380.1 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains YP_087381.1 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains YP_087383.1 Permeases of the major facilitator superfamily YP_087384.1 Predicted membrane protein YP_087385.1 Nicotinamide mononucleotide transporter YP_087387.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_087388.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_087389.1 Sugar kinases, ribokinase family YP_087390.1 involved in rpiB and als operon repression YP_087391.1 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components YP_087392.1 ABC-type sugar (aldose) transport system, ATPase component YP_087393.1 Periplasmic sugar-binding proteins YP_087395.1 SAM-dependent methyltransferases YP_087396.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_087397.1 Modulates Rho-dependent transcription termination YP_087399.1 binds directly to 23S ribosomal RNA YP_087400.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_087401.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_087402.2 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_087404.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_087405.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_087406.1 Predicted metal-binding protein related to the C-terminal domain of SecA YP_087408.1 Transcription-repair coupling factor - superfamily II helicase YP_087410.2 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_087411.1 With ArtMQJI transports arginine across the inner membrane YP_087412.1 ABC-type amino acid transport system, periplasmic component YP_087413.1 with ArtPMJI transports arginine across the inner membrane YP_087414.1 with ArtPQJI acts to transport arginine across the inner membrane YP_087415.1 Cytochrome c peroxidase YP_087416.1 Uncharacterized small membrane protein YP_087417.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_087419.1 Choline-glycine betaine transporter YP_087420.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_087422.1 Uncharacterized BCR YP_087423.1 Pseudouridylate synthases, 23S RNA-specific YP_087425.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_087427.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_087428.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_087429.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_087430.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_087431.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_087432.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_087433.1 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_087434.1 Diacylglycerol kinase YP_087435.1 Lipid A core - O-antigen ligase and related enzymes YP_087436.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_087437.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_087439.1 Ferredoxin 2 YP_087440.1 rRNA methylases YP_087442.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_087443.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_087444.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_087445.1 Uncharacterized stress-induced protein YP_087446.1 Predicted aminomethyltransferase related to GcvT YP_087447.2 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_087448.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_087449.1 Glutathione-S-transferases YP_087450.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_087452.2 Putative transcriptional regulator YP_087453.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_087454.1 Glutamine synthase YP_087455.1 Predicted membrane GTPase involved in stress response YP_087456.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_087457.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_087458.1 Predicted acyltransferases YP_087459.1 Uncharacterized lipoprotein YP_087463.1 heat shock protein involved in degradation of misfolded proteins YP_087464.1 heat shock protein involved in degradation of misfolded proteins YP_087465.1 Uncharacterized enzyme of heme biosynthesis YP_087466.1 Uncharacterized BCR YP_087467.1 Uroporphyrinogen-III synthase YP_087468.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_087469.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_087470.1 Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domain YP_087471.1 Uncharacterized BCR YP_087473.1 Uncharacterized BCR YP_087474.1 Dihydrodipicolinate synthase/N-acetylneuraminate lyase YP_087475.2 catalyzes the formation of D-ribose 5-phosphate from ribose YP_087476.1 Transcriptional regulators YP_087477.1 Predicted outer membrane protein YP_087478.1 Uncharacterized BCR YP_087479.1 Exopolyphosphatase YP_087480.1 Predicted permease YP_087481.1 Predicted permease YP_087482.1 ABC-type long-chain fatty acid transport system, fused permease and ATPase components YP_087483.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_087484.1 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 YP_087485.1 Nitric oxide reductase large subunit YP_087486.1 Nitric oxide reductase large subunit YP_087487.1 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_087489.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_087490.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_087492.1 Acetyltransferases YP_087493.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_087494.1 Uncharacterized BCR YP_087495.1 Membrane-associated lipoprotein involved in thiamine biosynthesis YP_087496.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_087497.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. YP_087498.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm YP_087499.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_087500.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_087501.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_087503.1 Stress-induced morphogen (activity unknown) YP_087504.1 Uncharacterized lipoprotein YP_087507.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_087508.1 Uncharacterized BCR YP_087509.1 A/G-specific DNA glycosylase YP_087510.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_087511.1 Uncharacterized BCR YP_087512.1 responsible for the influx of magnesium ions YP_087513.1 Predicted integral membrane protein YP_087514.1 Uncharacterized ACR YP_087515.1 Histone acetyltransferase HPA2 and related acetyltransferases YP_087516.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_087519.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_087520.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_087521.1 Universal stress protein UspA and related nucleotide-binding proteins YP_087522.1 Integral membrane protein, possible transporter YP_087523.1 Predicted periplasmic binding protein YP_087524.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_087525.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_087526.1 3-isopropylmalate dehydratase small subunit YP_087527.1 H+/gluconate symporter and related permeases YP_087528.1 Transcriptional regulator YP_087529.1 Rare lipoprotein B YP_087530.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_087533.1 Copper chaperone YP_087535.1 Transglutaminase-like enzymes, putative cysteine proteases YP_087537.1 UDP-glucose pyrophosphorylase YP_087538.1 Phosphomannomutase YP_087539.1 affects carbohydrate metabolism; has regulatory role in many processes YP_087540.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_087541.1 Universal stress protein UspA and related nucleotide-binding proteins YP_087543.1 Predicted pyrophosphatase YP_087544.1 Ribosome-associated protein Y (PSrp-1) YP_087545.1 Na+/alanine symporter YP_087549.1 Predicted acetyltransferase YP_087550.1 Uncharacterized BCR YP_087551.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_087552.1 Signal peptidase, cleaves prepilin-like proteins YP_087553.1 General secretory pathway protein F YP_087555.1 Predicted ATPases involved in pili biogenesis, PilB similarity YP_087556.1 General secretory pathway proteins G and H and related periplasmic/secreted proteins YP_087557.1 Negative regulator of beta-lactamase expression YP_087559.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_087560.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_087561.1 Signal peptidase I YP_087562.1 Signal peptidase I YP_087563.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_087564.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_087565.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_087566.1 Uncharacterized BCR YP_087568.1 Predicted Co/Zn/Cd cation transporters YP_087569.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_087571.1 Triosephosphate isomerase YP_087572.1 Transcriptional regulators of sugar metabolism YP_087573.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_087574.1 Uncharacterized BCR YP_087575.1 Ribose 5-phosphate isomerase RpiB YP_087576.1 transports degraded pectin products into the bacterial cell YP_087577.1 Putative protein-S-isoprenylcysteine methyltransferase YP_087579.1 Predicted membrane-associated, metal-dependent hydrolase YP_087581.1 Superoxide dismutase YP_087582.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_087583.1 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_087584.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_087586.1 ABC-type multidrug/protein/lipid transport system, ATPase component YP_087587.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_087588.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_087590.1 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases YP_087592.1 Formate/nitrite family of transporters YP_087593.1 Pyruvate-formate lyase YP_087595.1 activates pyruvate formate-lyase 1 under anaerobic conditions YP_087596.1 Cytosine/adenosine deaminases YP_087597.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_087598.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_087599.1 Predicted permeases YP_087600.1 hydrolyzes diadenosine polyphosphate YP_087601.1 Acts as a repressor of the mtlAD operon YP_087602.1 Mannitol-1-phosphate/altronate dehydrogenases YP_087603.1 Phosphotransferase system, mannitol-specific IIBC component YP_087605.1 Superfamily I DNA and RNA helicases YP_087608.1 Predicted phosphatase/phosphohexomutase YP_087609.1 Acetyltransferases (the isoleucine patch superfamily) YP_087610.1 Uncharacterized membrane protein YP_087611.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_087612.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_087614.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_087615.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_087616.1 Di- and tricarboxylate transporters YP_087617.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_087618.1 Nitrogen regulatory protein PII YP_087620.1 Predicted permease YP_087621.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_087622.1 involved in regulation of intracellular pH under alkaline conditions YP_087623.1 Multifunctional regulator of fatty acid metabolism YP_087624.1 Lipoprotein, attached to the cytoplasmic membrane YP_087625.1 Permease component of an uncharacterized ABC transporter YP_087626.1 part of the metNIQ transport system for methionine YP_087627.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_087629.1 Zn-dependent protease with chaperone function YP_087630.1 Glycosyltransferases involved in cell wall biogenesis YP_087631.1 ADP-heptoseLPS heptosyltransferase YP_087632.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_087633.2 Essential for efficient processing of 16S rRNA YP_087634.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_087635.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_087637.1 ADP-heptoseLPS heptosyltransferase YP_087638.1 Glycosyltransferase involved in LPS biosynthesis YP_087639.1 Lipopolysaccharide biosynthesis proteins, LPSglycosyltransferases YP_087640.1 Ribosomal protein L31 YP_087641.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_087642.1 Cell division protein YP_087645.1 Transcriptional regulator YP_087646.1 Membrane-fusion protein YP_087647.1 Cation/multidrug efflux pump YP_087649.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_087650.1 Co-chaperonin GroES (HSP10) YP_087651.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_087652.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_087653.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_087654.1 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component YP_087655.1 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component YP_087656.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_087657.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_087658.1 ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components YP_087659.1 SAM-dependent methyltransferases YP_087660.1 Predicted transcriptional regulators YP_087661.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_087662.1 binds single-stranded DNA at the primosome assembly site YP_087663.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_087664.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_087665.1 Exoribonucleases YP_087666.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_087667.1 5-formyltetrahydrofolate cyclo-ligase YP_087669.1 Uncharacterized BCR YP_087670.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_087671.1 Xaa-Pro aminopeptidase YP_087672.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_087673.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_087674.1 Uncharacterized ACR YP_087675.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_087676.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_087677.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_087678.1 binds the polymerase to DNA and acts as a sliding clamp YP_087679.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_087680.1 Branched-chain amino acid permeases YP_087682.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_087685.1 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) YP_087686.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_087687.1 Superfamily II DNA and RNA helicases YP_087689.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_087690.1 Uncharacterized ACR YP_087691.1 Permeases of the major facilitator superfamily YP_087692.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_087693.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_087694.1 Sec-independent protein secretion pathway component TatC YP_087695.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_087698.1 Cell envelope opacity-associated protein A YP_087699.1 Lysine 2, 3-aminomutase YP_087700.2 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_087701.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_087702.1 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_087703.1 Putative multicopper oxidases YP_087704.1 Uncharacterized membrane protein, possible Na+ channel or pump YP_087705.1 Periplasmic protein TonB, links inner and outer membranes YP_087706.1 Biopolymer transport protein YP_087707.1 Biopolymer transport proteins YP_087708.1 Outer membrane receptor proteins, mostly Fe transport YP_087709.1 Uncharacterized CBS domain-containing proteins YP_087710.1 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_087711.1 Signal recognition particle GTPase YP_087713.1 Predicted Na+-dependent transporter YP_087714.1 Predicted hydrolases of the HAD superfamily YP_087715.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_087716.1 Transcriptional regulators YP_087717.1 Threonine dehydrogenase and related Zn-dependent dehydrogenases YP_087718.1 Dicarboxylate-binding periplasmic protein YP_087719.1 Uncharacterized BCR YP_087720.1 Integral membrane protein, possible transporter YP_087721.1 catalyzes the formation of D-tagaturonate from D-altronate YP_087722.1 Altronate dehydratase YP_087723.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_087724.1 Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family YP_087725.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_087727.1 Permeases of the drug/metabolite transporter (DMT) superfamily YP_087729.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_087730.1 Transcriptional regulators YP_087731.1 Alpha-glucosidases, family 31 of glycosyl hydrolases YP_087732.1 Integral membrane protein, possible transporter YP_087733.1 Uncharacterized BCR YP_087734.1 Dicarboxylate-binding periplasmic protein YP_087735.1 Converts D-mannonate to D-mannuronate YP_087736.2 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_087737.1 Sugar kinases, ribokinase family YP_087738.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_087740.1 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases YP_087741.1 ABC-type proline/glycine betaine transport systems, ATPase components YP_087742.1 ABC-type proline/glycine betaine transport systems, permease component YP_087743.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine YP_087744.1 Amino acid transporters YP_087745.1 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) YP_087747.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_087748.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_087749.1 Predicted membrane protein YP_087750.1 Uncharacterized BCR YP_087751.1 Uncharacterized ACR YP_087752.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_087753.1 Outer membrane protein (porin) YP_087754.1 Transcriptional regulator YP_087755.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate YP_087756.1 Ribose 5-phosphate isomerase RpiB YP_087757.1 Sugar kinases, ribokinase family YP_087758.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_087759.1 Uncharacterized ACR, double-stranded beta-helix domain YP_087760.1 Predicted periplasmic solute-binding protein YP_087761.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_087762.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_087763.1 Mg-dependent DNase YP_087765.1 Uncharacterized CBS domain-containing proteins YP_087766.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_087767.1 Xanthine/uracil permeases YP_087769.1 Uncharacterized BCR YP_087770.1 Predicted permeases YP_087772.1 Spermidine/putrescine-binding periplasmic protein YP_087773.1 ABC-type spermidine/putrescine transport system, permease component II YP_087774.1 ABC-type spermidine/putrescine transport system, permease component I YP_087776.1 ABC-type sugar/spermidine/putrescine/iron/thiamine transport systems, ATPase component YP_087777.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_087778.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_087779.1 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit YP_087780.1 Anaerobic dehydrogenases, typically selenocysteine-containing YP_087782.1 functions in MreBCD complex in some organisms YP_087784.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_087785.1 Rod shape-determining protein YP_087787.2 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_087788.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_087789.1 Lactoylglutathione lyase and related lyases YP_087790.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_087791.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_087793.1 ATP-binding protein; required for proper cytochrome c maturation YP_087794.1 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_087795.1 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_087796.1 Heme exporter protein D YP_087797.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_087798.1 Cytochrome c biogenesis factor YP_087799.1 Thiol-disulfide isomerase and thioredoxins YP_087800.1 Uncharacterized protein involved in biosynthesis of c-type cytochromes YP_087801.1 TPR-repeat-containing proteins YP_087802.1 Lactoylglutathione lyase and related lyases YP_087803.1 Lactoylglutathione lyase and related lyases YP_087806.1 Phosphomannose isomerase YP_087808.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_087810.1 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB YP_087811.1 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism YP_087813.1 Predicted glutamine amidotransferase YP_087814.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_087815.1 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_087816.1 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_087817.1 Mg-dependent DNase YP_087818.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_087819.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_087820.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_087821.1 Parvulin-like peptidyl-prolyl isomerase YP_087822.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_087823.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_087824.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions YP_087825.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_087826.1 Membrane protein TerC, possibly involved in tellurium resistance YP_087827.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_087829.1 Methylated DNA-protein cysteine methyltransferase YP_087830.1 Long-chain fatty acid transport protein YP_087831.1 Periplasmic sugar-binding proteins YP_087833.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_087834.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_087835.1 Periplasmic sugar-binding proteins YP_087836.1 Transcriptional regulators YP_087837.1 Galactose-1-phosphate uridylyltransferase YP_087838.1 Galactose-1-phosphate uridylyltransferase YP_087839.1 Galactose-1-phosphate uridylyltransferase YP_087840.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_087841.2 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose YP_087843.1 Uncharacterized CBS domain-containing proteins YP_087844.1 Transfers the fatty acyl group on membrane lipoproteins YP_087846.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_087849.1 Membrane protein involved in the export of O-antigen and teichoic acid YP_087850.1 Cytidylyltransferase YP_087851.1 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC YP_087853.1 UDP-galactopyranose mutase YP_087854.1 Sugar transferases involved in lipopolysaccharide synthesis YP_087856.1 Glycosyltransferases involved in cell wall biogenesis YP_087859.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_087860.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_087861.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_087862.1 Starvation-inducible DNA-binding protein YP_087863.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction YP_087864.1 Arsenate reductase and related proteins, glutaredoxin family YP_087865.1 Predicted transposase YP_087866.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_087867.1 D-alanyl-D-alanine carboxypeptidase YP_087868.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_087869.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_087872.1 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 YP_087873.1 Uncharacterized BCR YP_087874.1 Predicted Zn-dependent proteases and their inactivated similarity YP_087875.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively YP_087876.1 Gluconolactonase YP_087878.1 H+/gluconate symporter and related permeases YP_087879.1 Aldo/keto reductases, related to diketogulonate reductase YP_087880.1 H+/gluconate symporter and related permeases YP_087881.1 O-succinylbenzoate synthase and related enzymes YP_087883.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate YP_087884.1 catalyzes the reduction of tartronate semialdehyde to glycerate YP_087885.1 Glycerate kinase YP_087886.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization YP_087887.1 Altronate dehydratase YP_087888.1 Integral membrane protein, possible transporter YP_087889.1 Uncharacterized BCR YP_087890.1 Dicarboxylate-binding periplasmic protein YP_087891.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_087893.1 Predicted permease YP_087894.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_087895.1 Lactoylglutathione lyase and related lyases YP_087896.1 ABC-type amino acid transport system, periplasmic component YP_087898.1 SAM-dependent methyltransferases YP_087900.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_087901.1 converts dATP to dAMP and pyrophosphate YP_087902.1 Uncharacterized ACR YP_087903.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_087904.2 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_087905.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_087907.1 Cytochrome bd-type quinol oxidase, subunit 1 YP_087908.1 Cytochrome bd-type quinol oxidase, subunit 2 YP_087911.1 Predicted thioesterase YP_087912.1 Biopolymer transport proteins YP_087913.2 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_087914.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins YP_087915.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_087916.1 General secretory pathway proteins G and H and related periplasmic/secreted proteins YP_087920.1 Exonuclease V gamma subunit YP_087921.1 Preprotein translocase subunit YP_087922.1 decatenates replicating daughter chromosomes YP_087923.1 unknown function YP_087924.1 Uncharacterized anaerobic dehydrogenase YP_087926.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_087927.2 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_087928.1 Acyl-CoA hydrolase YP_087929.1 Involved in cell division; probably involved in intracellular septation YP_087932.1 Outer membrane protein W YP_087933.1 ATPases involved in DNA repair YP_087934.1 catalyzes the phosphorylation of NAD to NADP YP_087935.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_087936.1 Represses a number of genes involved in the response to DNA damage YP_087937.2 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_087938.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_087939.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_087941.1 Beta-galactosidase/beta-glucuronidase YP_087942.1 Uncharacterized ACR YP_087943.1 Uncharacterized conserved protein containing a ferredoxin-like domain YP_087944.1 Fe-S oxidoreductases YP_087945.1 L-lactate permease YP_087946.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_087947.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_087948.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_087949.1 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) YP_087950.1 Predicted esterase YP_087952.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_087954.1 Transcriptional regulator of aromatic amino acids metabolism YP_087955.1 Transcriptional regulator YP_087956.1 Predicted branched-chain amino acid permease (azaleucine resistance) YP_087957.1 Predicted branched-chain amino acid permeases (azaleucine resistance) YP_087959.1 Na+/alanine symporter YP_087960.2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_087963.1 Phosphomannomutase YP_087964.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_087966.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_087967.2 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_087968.1 SAM-dependent methyltransferases YP_087969.1 Na+/proline, Na+/panthothenate symporters and related permeases YP_087970.1 involved in the processing of the 5'end of 16S rRNA YP_087972.1 Predicted Zn-dependent proteases and their inactivated similarity YP_087974.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxog YP_087975.1 PLP-dependent aminotransferases YP_087976.1 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific YP_087977.1 Permeases of the major facilitator superfamily YP_087978.1 Collagenase and related proteases YP_087979.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor YP_087981.1 ABC-type Mn2+/Zn2+ transport systems, permease components YP_087982.1 ABC-type Mn/Zn transport systems, ATPase component YP_087983.1 Membrane proteins related to metalloendopeptidases YP_087984.1 ABC-type cobalamin/Fe3+-siderophores transport systems, permease components YP_087985.1 ABC-type cobalamin/Fe3+-siderophores transport systems, permease components YP_087986.1 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components YP_087987.1 ABC-type Fe3+-siderophores transport systems, periplasmic components YP_087988.2 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_087989.1 Permeases of the major facilitator superfamily YP_087990.1 UDP-glucose 4-epimerase YP_087992.1 Uncharacterized membrane protein YP_087994.1 Permeases YP_087996.1 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_087997.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_087998.1 Beta-galactosidase/beta-glucuronidase YP_087999.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments YP_088000.1 Transcriptional regulators YP_088001.1 Spermidine/putrescine-binding periplasmic protein YP_088002.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_088003.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_088004.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_088007.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_088009.1 Paraquat-inducible protein B YP_088010.1 Uncharacterized paraquat-inducible protein A YP_088011.1 Uncharacterized paraquat-inducible protein A YP_088012.1 affects solute and DNA transport through an unknown mechanism YP_088013.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_088014.1 Uncharacterized BCR YP_088015.1 Uncharacterized BCR YP_088016.1 Zn-dependent hydrolases, including glyoxylases YP_088018.1 DNA uptake protein and related DNA-binding proteins YP_088019.1 Glutamate decarboxylase and related PLP-dependent proteins YP_088021.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_088024.1 involved in the import of serine and threonine coupled with the import of sodium YP_088025.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum YP_088026.1 Membrane protease subunits, stomatin/prohibitin similarity YP_088027.1 Membrane protein implicated in regulation of membrane protease activity YP_088028.1 Putative NADPH-quinone reductase (modulator of drug activity B) YP_088029.1 Uncharacterized component of anaerobic dehydrogenases YP_088030.1 Uncharacterized membrane protein YP_088031.2 catalyzes the formation of methylglyoxal from glycerone phosphate YP_088032.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_088034.1 Predicted hydrolases of the HAD superfamily YP_088035.1 required for the formation of active formate dehydrogenase YP_088036.1 Uncharacterized BCR YP_088037.1 catalyzes the hydrolysis of acylphosphate YP_088038.1 Sulfite reductase, gamma subunit YP_088039.1 Integral membrane protein, interacts with FtsH YP_088041.1 D-alanyl-D-alanine carboxypeptidase YP_088042.1 D-alanyl-D-alanine carboxypeptidase YP_088044.1 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component YP_088045.1 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component YP_088046.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_088047.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_088048.1 ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components YP_088049.1 Predicted ATPase YP_088050.1 negatively supercoils closed circular double-stranded DNA YP_088051.1 Fe2+/Zn2+ uptake regulation proteins YP_088052.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_088054.1 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_088055.2 negative modulator of the initiation of chromosome replication YP_088056.1 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_088057.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_088058.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_088059.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_088060.1 Predicted permeases YP_088061.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_088062.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_088063.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_088064.1 Uncharacterized BCR YP_088066.1 TPR repeat proteins YP_088067.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_088068.1 Putative multicopper oxidases YP_088070.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_088071.1 Predicted Na+-dependent transporter YP_088074.1 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_088075.1 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family YP_088076.1 Transcriptional regulator YP_088077.1 Permeases of the drug/metabolite transporter (DMT) superfamily YP_088078.1 Predicted transcriptional regulators YP_088079.1 Cation transport ATPases YP_088080.1 Cation transport ATPases YP_088081.1 Cytochrome b subunit of formate dehydrogenase YP_088082.1 Fe-S-cluster-containing hydrogenase components 1 YP_088083.1 Anaerobic dehydrogenases, typically selenocysteine-containing YP_088084.1 Anaerobic dehydrogenases, typically selenocysteine-containing YP_088085.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_088086.1 Predicted SAM-dependent methyltransferase YP_088087.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_088088.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_088090.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_088091.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_088092.1 ABC-type amino acid transport system, periplasmic component YP_088093.1 Membrane-bound lytic murein transglycosylase B YP_088094.1 Glycosyltransferases involved in cell wall biogenesis YP_088095.1 Glycosyltransferases involved in cell wall biogenesis YP_088097.1 Glycosyltransferase involved in LPS biosynthesis YP_088100.1 Uncharacterized ACR YP_088101.1 Beta-fructosidases (levanase/invertase) YP_088102.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_088103.1 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase YP_088106.1 Na+-dependent transporters of the SNF family YP_088108.1 Predicted EndoIII-related endonuclease YP_088109.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_088110.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_088111.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_088112.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_088113.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_088114.2 Na+-transporting NADHubiquinone oxidoreductase subunit 5 YP_088115.1 Uncharacterized membrane protein YP_088116.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_088117.1 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase YP_088118.1 tRNA nucleotidyltransferase/poly(A) polymerase YP_088119.1 DnaK suppressor protein YP_088123.1 Predicted multitransmembrane, metal-binding protein YP_088124.1 involved in the transport of lipid A across the inner membrane YP_088125.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_088126.1 Uncharacterized BCR YP_088127.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_088129.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_088131.1 catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA YP_088133.1 Methionine synthase II (cobalamin-independent) YP_088135.1 Uncharacterized BCR YP_088136.1 Uncharacterized ACR YP_088137.1 SAM-dependent methyltransferases YP_088138.1 Zn-dependent hydrolases, including glyoxylases YP_088139.1 Predicted iron-dependent peroxidase YP_088140.1 Acyl-CoA thioesterase YP_088141.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_088142.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_088143.1 Thioredoxin reductase YP_088144.1 Thioredoxin domain-containing protein YP_088145.1 H+/gluconate symporter and related permeases YP_088146.1 H+/gluconate symporter and related permeases YP_088147.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate YP_088148.1 NAD-binding YP_088149.1 Gluconate kinase YP_088151.1 Phosphatidylglycerophosphate synthase YP_088152.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_088153.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_088154.1 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein YP_088155.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_088156.1 ATP-dependent Zn proteases YP_088158.1 Dihydropteroate synthase YP_088159.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_088160.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_088161.1 Ferredoxin YP_088162.1 Di- and tricarboxylate transporters YP_088163.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_088164.1 Putative threonine efflux protein YP_088165.1 Phosphatidylglycerophosphatase A YP_088166.1 Thiamine monophosphate kinase YP_088167.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_088168.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_088169.1 Amino acid permeases YP_088170.1 Putative transposase YP_088171.1 Transposase YP_088172.1 Uncharacterized ACR YP_088173.1 Uncharacterized ACR YP_088175.1 Uncharacterized ACR YP_088177.1 RecB family exonuclease YP_088178.1 Uncharacterized BCR YP_088183.1 Predicted helicases YP_088184.1 Catalyzes the rate-limiting step in dNTP synthesis YP_088185.1 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_088187.1 Uncharacterized proteins of HAD superfamily, CMP-Neu5Ac similarity YP_088188.1 Predicted sugar phosphate isomerase involved in capsule formation YP_088190.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_088191.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_088193.1 Uncharacterized BCR YP_088194.1 Uncharacterized membrane protein, required for colicin V production YP_088195.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_088196.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_088197.1 Molybdopterin biosynthesis enzyme YP_088198.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_088201.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_088202.1 Predicted transposase YP_088204.1 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components YP_088205.1 ABC-type cobalamin/Fe3+-siderophores transport systems, permease components YP_088207.1 Outer membrane receptor proteins, mostly Fe transport YP_088208.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein YP_088209.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_088210.1 Permeases YP_088211.1 Uncharacterized ACR involved in intracellular sulfur reduction YP_088212.1 Uncharacterized ACR YP_088213.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_088214.1 Molybdenum cofactor biosynthesis enzyme YP_088215.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_088216.1 Molybdopterin converting factor, large subunit YP_088218.1 Adenine specific DNA methylase Mod YP_088219.1 Restriction endonuclease YP_088220.1 Cytochrome b subunit of formate dehydrogenase YP_088221.1 Fe-S-cluster-containing hydrogenase components 1 YP_088222.1 Anaerobic dehydrogenases, typically selenocysteine-containing YP_088223.2 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_088224.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_088225.1 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway YP_088226.1 Aminopeptidase N YP_088227.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_088228.1 Predicted metal-dependent phosphoesterases (PHP family) YP_088229.1 Putative translation factor (SUA5) YP_088230.1 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_088231.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_088234.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_088235.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_088239.1 Uncharacterized BCR YP_088240.2 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_088242.1 Predicted phosphatase/phosphohexomutase YP_088243.1 Uncharacterized BCR YP_088244.1 cofactor involved in the reduction of disulfides YP_088245.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_088246.1 Translation initiation factor IF3 YP_088247.2 Ribosomal protein L35 YP_088248.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_088250.1 Lipoate-protein ligase A YP_088251.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_088252.1 Geranylgeranyl pyrophosphate synthase YP_088253.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_088254.1 Required for the synthesis of the thiazole moiety YP_088255.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers YP_088257.1 Carbonic anhydrase YP_088258.1 ABC-type multidrug transport system, ATPase component YP_088259.1 ABC-type multidrug transport system, permease component YP_088260.1 Predicted Rossmann fold nucleotide-binding protein YP_088261.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_088263.1 Uncharacterized BCR YP_088264.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_088265.1 Ornithine carbamoyltransferase YP_088266.1 Uncharacterized BCR YP_088268.2 with UspC and UspD is involved in resistance to UV irradiation YP_088269.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_088271.1 Ferritin-like protein YP_088272.1 Ferritin-like protein YP_088273.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_088276.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_088277.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division YP_088278.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_088279.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_088280.1 Cell wall-associated hydrolases (invasion-associated proteins) YP_088281.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_088282.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_088283.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_088284.1 Uncharacterized BCR YP_088286.1 Plasmid maintenance system antidote protein YP_088287.1 Cold shock proteins YP_088288.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_088289.1 Transcriptional regulator YP_088290.1 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member YP_088291.1 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) YP_088293.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_088294.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_088296.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_088297.1 Isocitrate/isopropylmalate dehydrogenase YP_088299.1 Periplasmic serine proteases (ClpP class) YP_088301.1 Nitroreductase YP_088303.1 N-acetyl-beta-hexosaminidase YP_088304.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein YP_088305.1 Predicted xylanase/chitin deacetylase YP_088308.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_088310.1 Uncharacterized membrane-associated protein YP_088311.1 Glucan phosphorylase YP_088312.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_088313.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_088314.1 Pullulanase and related glycosidases YP_088315.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_088316.1 4-alpha-glucanotransferase YP_088317.1 Uncharacterized ACR YP_088319.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_088320.1 Membrane-fusion protein YP_088321.1 ABC-type transport systems, involved in lipoprotein release, permease components YP_088323.1 Outer membrane protein YP_088324.1 Uncharacterized BCR YP_088325.1 Uncharacterized BCR YP_088326.1 putative metalloprotease YP_088327.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_088329.1 Predicted ATP-dependent endonuclease of the OLD family YP_088330.1 Uncharacterized membrane protein YP_088332.1 Rhodanese-related sulfurtransferases YP_088333.1 Rhodanese-related sulfurtransferases YP_088334.1 Predicted transporter components YP_088336.1 Cold shock proteins YP_088337.1 Small protein A (tmRNA-binding) YP_088338.1 SohB; periplasmic protein; member of the peptidase S49 family YP_088341.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_088342.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_088343.2 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_088344.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_088345.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_088346.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_088349.1 Ferrous ion uptake system protein FeoB (predicted GTPase) YP_088350.1 Ferrous ion uptake system protein FeoB (predicted GTPase) YP_088353.1 Opacity protein and related surface antigens YP_088355.1 Putative hemagglutinin/hemolysin YP_088359.1 Putative hemagglutinin/hemolysin YP_088360.1 ACPhemolysine acyltransferase (hemolysin-activating protein) YP_088361.1 Hemolysin activation/secretion protein YP_088362.1 Pseudouridylate synthases, 23S RNA-specific YP_088363.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_088364.1 Phosphoglycerate mutase/fructose-2, 6-bisphosphatase YP_088365.1 Folylpolyglutamate synthase YP_088366.2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_088367.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_088369.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_088370.1 Permeases of the major facilitator superfamily YP_088372.1 Integral membrane proteins of the MarC family YP_088373.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_088374.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_088375.2 unwinds double stranded DNA YP_088376.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_088377.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_088378.1 ABC-type transport systems, involved in lipoprotein release, ATPase components YP_088379.1 ABC-type transport systems, involved in lipoprotein release, permease components YP_088380.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor YP_088381.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_088382.1 Uncharacterized ACR YP_088383.1 Predicted rRNA or tRNA methylase YP_088384.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_088386.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_088387.1 Predicted ATP-dependent protease YP_088388.1 Uncharacterized BCR YP_088389.2 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_088390.1 Phosphohistidine phosphatase SixA YP_088391.1 Zn-dependent oligopeptidases YP_088393.1 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components YP_088394.1 ABC-type Fe3+-siderophores transport systems, periplasmic components YP_088395.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_088396.1 efflux pump for the antibacterial peptide microcin J25 YP_088397.1 Outer membrane receptor proteins, mostly Fe transport YP_088400.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_088401.1 Aldo/keto reductases, related to diketogulonate reductase YP_088402.1 Transcriptional regulator YP_088403.1 Predicted sugar kinase YP_088404.1 Glutaredoxin-related proteins YP_088407.1 Beta-propeller domains of methanol dehydrogenase type YP_088409.1 Uncharacterized ACR YP_088410.1 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_088411.1 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_088412.1 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_088413.1 FAD/FMN-containing dehydrogenases YP_088414.1 GT/U mismatch-specific DNA glycosylase YP_088415.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_088416.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_088419.1 Alpha-galactosidase YP_088420.1 Na+/melibiose symporter and related transporters YP_088421.1 AraC-type DNA-binding domain-containing proteins YP_088422.1 Regulatory factor involved in maltose metabolism YP_088424.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_088425.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least YP_088428.1 Glycosidases YP_088429.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_088430.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon YP_088432.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_088433.1 Selenophosphate synthase YP_088434.1 Transcriptional regulators YP_088435.1 Involved in anaerobic NO protection and iron metabolism YP_088436.1 Sensory transduction histidine kinases YP_088437.1 Sensory transduction histidine kinases YP_088438.1 Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domain YP_088439.1 Uncharacterized ACR YP_088440.1 PLP-dependent aminotransferases YP_088441.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_088442.1 Sulfite reductase flavoprotein subunit YP_088443.1 GTPases - Sulfate adenylate transferase subunit 1 YP_088444.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_088445.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_088446.1 Uroporphyrinogen-III methylase YP_088447.1 ABC-type sulfate transport system, periplasmic component YP_088451.1 ABC-type sulfate/molybdate transport systems, permease components YP_088452.1 ABC-type sulfate/molybdate transport systems, permease components YP_088453.1 ABC-type sulfate/molybdate transport systems, ATPase component YP_088454.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_088455.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_088456.1 Uncharacterized BCR YP_088457.1 involved in methylation of ribosomal protein L3 YP_088458.1 oxidizes malate to oxaloacetate YP_088459.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_088460.1 Predicted nucleoside-diphosphate sugar epimerases (SulA family) YP_088461.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_088462.1 Putative effector of murein hydrolase YP_088463.1 Putative effector of murein hydrolase LrgA YP_088464.1 Micrococcal nuclease (thermonuclease) similarity YP_088465.1 Selenocysteine lyase YP_088466.1 SufE protein probably involved in Fe-S center assembly YP_088467.1 ABC-type polar amino acid transport system, ATPase component YP_088468.1 ABC-type amino acid transport system, permease component YP_088469.1 ABC-type amino acid transport system, periplasmic component YP_088470.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_088472.1 Stringent starvation protein B YP_088473.1 Glutathione-S-transferases YP_088474.1 Ribosomal protein S9 YP_088475.2 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_088478.1 Uncharacterized BCR YP_088479.1 Predicted methyltransferases YP_088480.1 Putative lipoprotein YP_088481.1 Predicted endonuclease distantly related to archaeal Holliday junction resolvase YP_088482.1 Phosphoheptose isomerase YP_088483.1 Predicted periplasmic or secreted lipoprotein YP_088485.1 Predicted Co/Zn/Cd cation transporters YP_088486.1 Predicted membrane protein YP_088487.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_088488.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_088489.1 involved in de novo purine biosynthesis YP_088491.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_088492.1 Transcriptional regulator YP_088493.1 Membrane-fusion protein YP_088494.1 ABC-type multidrug transport system, ATPase component YP_088495.1 ABC-type multidrug transport system, permease component YP_088496.1 Outer membrane protein YP_088497.1 UTPGlnB (protein PII) uridylyltransferase YP_088498.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_088499.1 Uncharacterized ACR YP_088500.2 Uncharacterized BCR YP_088503.1 L-serine deaminase YP_088504.1 Membrane carboxypeptidase (penicillin-binding protein) YP_088505.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_088506.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_088507.1 Outer membrane receptor proteins, mostly Fe transport YP_088508.1 ABC-type long-chain fatty acid transport system, fused permease and ATPase components YP_088509.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_088510.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_088511.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate YP_088513.1 Na+/H+ antiporter YP_088514.1 DNA-binding protein H-NS YP_088515.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_088516.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_088517.1 ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components YP_088518.1 Outer membrane lipoprotein YP_088520.1 Uncharacterized BCR YP_088522.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_088525.1 Cell wall-associated hydrolases (invasion-associated proteins) YP_088526.2 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_088527.2 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains YP_088528.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_088529.1 Outer membrane protein (porin) YP_088530.1 with TehA confers resistance to tellurite YP_088531.1 Uncharacterized BCR YP_088532.1 Part of the ABC transporter complex modABC involved in molybdenum import YP_088533.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_088534.1 ABC-type molybdate transport system, periplasmic component YP_088536.1 N-terminal domain of molybdenum-binding protein YP_088537.1 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_088538.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_088539.1 O-acetylhomoserine sulfhydrylase YP_088540.1 O-acetylhomoserine sulfhydrylase YP_088541.1 Nitroreductase YP_088543.1 Succinyl-CoA synthetase alpha subunit YP_088544.1 catalyzes the interconversion of succinyl-CoA and succinate YP_088546.1 Dihydrolipoamide acyltransferases YP_088547.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_088549.1 Ribonuclease D YP_088550.1 Activates fatty acids by binding to coenzyme A YP_088551.1 Starvation-inducible outer membrane lipoprotein YP_088552.1 Inactive similarity of metal-dependent proteases, putative molecular chaperones YP_088553.1 Rad3-related DNA helicases YP_088554.1 Uncharacterized enzymes related to aldose 1-epimerase YP_088555.1 Predicted permeases YP_088556.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_088557.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF YP_088558.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_088559.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_088560.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_088562.1 ABC-type iron/thiamine transport systems, periplasmic component YP_088563.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_088564.1 Ca2+/Na+ antiporter YP_088565.1 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_088566.1 Pyrimidine reductase, riboflavin biosynthesis YP_088567.1 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains YP_088568.1 Phospholipid-binding protein YP_088570.1 Di- and tricarboxylate transporters YP_088571.1 ACT domain-containing protein YP_088572.1 Uncharacterized ACR YP_088577.1 Predicted transcriptional regulators YP_088578.1 Zn-dependent alcohol dehydrogenases, class III YP_088579.1 Predicted esterase YP_088580.1 Predicted dehydrogenases and related proteins YP_088582.1 Predicted ATP-dependent endonuclease of the OLD family YP_088586.1 Coenzyme F420-dependent N5, N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases YP_088587.1 Transcriptional regulator YP_088590.1 Uncharacterized ATPase related to the helicase subunit of the Holliday junction resolvase YP_088592.1 AraC-type DNA-binding domain-containing proteins YP_088593.1 Transposase YP_088595.1 Transcriptional regulator YP_088597.1 Putative NADH-flavin reductase YP_088598.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_088599.1 Permeases of the major facilitator superfamily YP_088600.1 Phosphotransferase system IIA components YP_088601.1 Na+/melibiose symporter and related transporters YP_088603.1 Sugar (pentulose and hexulose) kinases YP_088604.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_088605.1 Transcriptional regulators YP_088606.1 Predicted dehydrogenases and related proteins YP_088607.1 Transcriptional regulator YP_088609.1 Putative NADPH-quinone reductase (modulator of drug activity B) YP_088610.1 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) YP_088611.1 Esterase/lipase YP_088613.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_088614.1 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) YP_088615.1 Putative intracellular protease/amidase YP_088616.1 Uncharacterized ACR, similar to gamma-carboxymuconolactone decarboxylase subunit YP_088618.1 Predicted metal-dependent hydrolase of the TIM-barrel fold YP_088619.1 Predicted metal-dependent hydrolase of the TIM-barrel fold YP_088620.1 Predicted Zn-dependent hydrolases of the beta-lactamase fold YP_088625.1 Predicted transcriptional regulators YP_088626.1 Co/Zn/Cd efflux system component YP_088628.1 Periplasmic serine proteases (ClpP class) YP_088629.2 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain YP_088630.1 Predicted secreted acid phosphatase YP_088631.1 Uncharacterized membrane protein YP_088632.1 Predicted permeases YP_088633.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_088634.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_088636.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_088637.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_088638.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_088642.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_088643.1 Uncharacterized ATPase related to the helicase subunit of the Holliday junction resolvase YP_088644.2 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_088647.2 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_088649.2 involved in transport of zinc(II) with ZnuA and C YP_088650.1 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 YP_088651.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_088653.1 Hydrogenase maturation factor YP_088654.1 Hydrogenase maturation factor YP_088655.1 GTP hydrolase involved in nickel liganding into hydrogenases YP_088656.1 Uncharacterized ACR YP_088659.1 Enoyl-acyl-carrier-protein reductase (NADH) YP_088660.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_088661.1 Uncharacterized BCR YP_088663.1 involved in start site selection during the initiation of translation YP_088664.1 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_088665.1 Predicted N-acetylglucosaminyl transferase YP_088667.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_088668.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_088669.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_088670.1 Predicted membrane protein, putative toxin regulator YP_088671.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_088672.1 Nucleoside-diphosphate-sugar epimerases YP_088673.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_088678.1 Uncharacterized protein involved in exopolysaccharide biosynthesis YP_088679.1 Periplasmic protein involved in polysaccharide export YP_088680.1 Predicted nucleoside-diphosphate sugar epimerases YP_088681.1 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis YP_088682.1 Predicted hydrolases of the HAD superfamily YP_088683.1 undetermined role; similar to CarB protein but much smaller YP_088684.1 Sugar transferases involved in lipopolysaccharide synthesis YP_088686.1 Predicted glycosyltransferases YP_088687.1 Membrane protein involved in the export of O-antigen and teichoic acid YP_088688.1 Predicted glycosyltransferases YP_088689.1 Predicted glycosyltransferases YP_088690.1 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis YP_088691.1 Acetyltransferases (the isoleucine patch superfamily) YP_088692.1 Predicted dehydrogenases and related proteins YP_088693.1 UDP-N-acetyl-D-mannosaminuronate dehydrogenase YP_088695.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_088696.1 Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domain YP_088697.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_088698.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_088699.1 Uncharacterized BCR YP_088700.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_088701.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system YP_088702.1 Phosphotransferase system, HPr-related proteins YP_088703.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_088704.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_088706.1 Predicted ATPase or kinase YP_088707.1 N-acetylmuramoyl-L-alanine amidase YP_088708.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_088709.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_088710.1 Stimulates the elongation of poly(A) tails YP_088711.1 GTPases YP_088712.1 catalyzes the formation of L-homocysteine from cystathionine YP_088713.1 Peroxiredoxin YP_088714.1 Uncharacterized BCR YP_088715.1 Biotin synthase and related enzymes YP_088716.1 ABC-type sugar/spermidine/putrescine/iron/thiamine transport systems, ATPase component YP_088717.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_088718.1 ABC-type iron/thiamine transport systems, periplasmic component YP_088719.2 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine YP_088720.1 Predicted dehydrogenases and related proteins YP_088721.1 Sugar phosphate isomerases/epimerases YP_088722.1 Permeases of the major facilitator superfamily YP_088723.1 Transcriptional regulators YP_088724.1 Membrane-associated phospholipid phosphatase YP_088725.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_088726.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_088727.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_088728.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_088729.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_088730.1 Thiol-disulfide isomerase and thioredoxins YP_088731.1 Single-stranded DNA-specific exonuclease YP_088732.1 Protein-disulfide isomerase YP_088734.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_088735.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_088737.1 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) YP_088738.1 Hydrogenase maturation factor YP_088740.1 Predicted permeases YP_088741.1 Predicted permeases YP_088742.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_088743.1 NAD-dependent aldehyde dehydrogenases YP_088744.1 Metal-dependent amidase/aminoacylase/carboxypeptidase YP_088745.1 C4-dicarboxylate transporter YP_088746.1 Peptidase E YP_088747.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_088748.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_088749.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_088750.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_088751.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_088753.1 Predicted transcriptional regulators YP_088754.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_088755.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_088756.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_088757.1 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_088758.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_088759.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_088760.1 Short-chain dehydrogenases of various substrate specificities YP_088761.1 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily YP_088762.1 3'-5' exonuclease of DNA polymerase III YP_088763.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_088764.1 Uncharacterized BCR YP_088765.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_088766.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_088767.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_088769.1 Putative transposase YP_088770.1 Transposase YP_088771.1 Arabinose efflux permease YP_088773.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_088774.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_088775.1 ABC-type iron/thiamine transport systems, periplasmic component YP_088777.1 ABC-type iron/thiamine transport systems, periplasmic component YP_088778.1 ABC-type thiamine transport system, permease components YP_088779.2 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import YP_088780.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_088781.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_088782.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18 YP_088783.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_088784.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_088785.1 dTDP-D-glucose 4, 6-dehydratase YP_088786.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_088787.1 Permeases of the drug/metabolite transporter (DMT) superfamily YP_088788.1 Permeases of the drug/metabolite transporter (DMT) superfamily YP_088790.1 involved in the peptidyltransferase reaction during translation YP_088791.2 Ribosomal protein L21 YP_088792.1 Geranylgeranyl pyrophosphate synthase YP_088793.1 Uncharacterized BCR YP_088794.1 Putative transposase YP_088795.1 Transposase YP_088796.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_088797.1 Predicted membrane protein YP_088798.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_088799.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone YP_088800.1 Uncharacterized BCR YP_088801.1 Sugar (pentulose and hexulose) kinases YP_088802.1 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components YP_088803.1 ABC-type sugar (aldose) transport system, ATPase component YP_088804.1 Periplasmic sugar-binding proteins YP_088805.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_088806.1 UDP-N-acetylmuramate-alanine ligase YP_088807.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_088809.1 Glutathione-S-transferases YP_088811.1 Membrane protease subunits, stomatin/prohibitin similarity YP_088812.1 Membrane protease subunits, stomatin/prohibitin similarity YP_088813.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_088814.1 Ribonucleases G and E YP_088816.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA YP_088818.1 Thiol-disulfide isomerase and thioredoxins YP_088819.1 catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity YP_088822.1 Predicted phosphohydrolases YP_088823.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_088824.1 ATPases involved in chromosome partitioning YP_088825.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_088827.1 Uncharacterized ACR YP_088838.1 Transposase YP_088841.1 Uncharacterized ACR YP_088843.1 Predicted hydrolase of the HD superfamily (permuted catalytic motifs) YP_088844.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_088845.2 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_088846.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_088847.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_088849.1 Prephenate dehydratase YP_088850.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_088851.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_088853.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_088854.1 Predicted ATPases of the HSP70 class involved in cell division YP_088855.1 Cell division septal protein YP_088856.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_088858.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_088859.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_088860.1 Bacterial cell division membrane protein YP_088861.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_088862.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_088863.1 UDP-N-acetylmuramyl pentapeptide synthase YP_088864.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_088865.1 Cell division protein FtsI/penicillin-binding protein 2 YP_088866.1 Cell division protein YP_088867.1 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis YP_088868.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_088869.1 Carbon starvation protein, predicted membrane protein YP_088871.1 Predicted P-loop ATPase fused to an acetyltransferase YP_088872.1 Predicted metal-dependent hydrolase YP_088873.1 Putative threonine efflux protein YP_088874.1 Phosphate starvation-inducible protein PhoH, predicted ATPase YP_088875.1 Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine YP_088876.1 ABC-type amino acid transport system, periplasmic component YP_088877.1 ABC-type polar amino acid transport system, ATPase component YP_088878.1 ABC-type amino acid transport system, permease component YP_088879.1 ABC-type amino acid transport system, permease component YP_088881.1 Transcriptional regulator YP_088882.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_088885.1 Predicted phosphohydrolases YP_088886.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_088887.1 Phosphopantetheinyl transferase YP_088888.1 molecular chaperone YP_088889.1 Opacity protein and related surface antigens YP_088890.1 Uncharacterized BCR YP_088891.1 Uncharacterized BCR YP_088893.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_088894.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_088895.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_088896.1 Cu/Zn superoxide dismutase YP_088897.1 Predicted enzyme with a TIM-barrel fold YP_088899.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_088900.1 Stress-induced morphogen (activity unknown) YP_088901.1 STAS domain protein YP_088902.1 Uncharacterized periplasmic protein YP_088903.1 Permease component of an ABC-transporter YP_088904.1 ABC-type toluene export system, permease component YP_088905.1 Uncharacterized ABC-type transport system, ATPase component YP_088906.1 Uncharacterized BCR YP_088907.1 Uncharacterized BCR YP_088908.1 ABC-type (unclassified) transport system, ATPase component YP_088909.1 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) YP_088910.1 Predicted P-loop-containing kinase YP_088911.1 Uncharacterized BCR YP_088912.1 Ferredoxin YP_088913.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_088914.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_088915.1 Uncharacterized ACR YP_088916.1 NifU similarity involved in Fe-S cluster formation YP_088918.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_088919.1 Predicted transcriptional regulator YP_088920.1 rRNA methylase YP_088921.1 Archaeal fructose-1, 6-bisphosphatase and related enzymes of inositol monophosphatase family YP_088922.1 Sensory transduction histidine kinases YP_088926.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_088927.1 catalyzes branch migration in Holliday junction intermediates YP_088928.1 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_088929.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_088930.1 Essential for recycling GMP and indirectly, cGMP YP_088931.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate YP_088933.1 Na+/proline, Na+/panthothenate symporters and related permeases YP_088935.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_088936.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_088938.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_088939.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_088940.1 DNA uptake protein and related DNA-binding proteins YP_088941.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_088942.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_088943.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_088944.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_088945.1 Permeases of the drug/metabolite transporter (DMT) superfamily YP_088946.1 Permeases of the drug/metabolite transporter (DMT) superfamily YP_088947.1 Uncharacterized membrane protein, putative virulence factor YP_088948.2 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_088950.1 catalyzes the formation of serine from O-phosphoserine YP_088951.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_088952.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_088953.1 synthesizes RNA primers at the replication forks YP_088954.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_088955.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_088956.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_088958.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_088960.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_088961.1 putative role in sulfur assimilation YP_088962.1 Cysteine synthase YP_088966.1 TPR-repeat-containing proteins YP_088967.1 Predicted membrane protein YP_088968.1 Predicted acyl dehydratase YP_088969.1 Predicted ATPases involved in pili and flagella biosynthesis, VirB11 family YP_088971.1 General secretory pathway protein D YP_088975.1 ATPases with chaperone activity, ATP-binding subunit YP_088976.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_088977.1 Uncharacterized BCR YP_088978.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_088980.2 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_088981.2 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_088982.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_088983.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_088984.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_088985.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA YP_088986.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_088987.1 synthesizes isochorismate acid from chorismate YP_088989.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_088990.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_088991.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_088992.1 Required for efficient pilin antigenic variation YP_088993.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_088994.1 Alcohol dehydrogenase IV YP_088995.1 Transposase YP_088996.1 Putative transposase YP_088997.1 Carbonic anhydrase YP_088998.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_089000.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_089002.1 Predicted flavoproteins YP_089003.1 TPR-repeat-containing proteins YP_089004.1 Uncharacterized protein involved in biosynthesis of c-type cytochromes YP_089005.1 Thiol-disulfide isomerase and thioredoxins YP_089006.1 Cytochrome c biogenesis factor YP_089008.1 Formate-dependent nitrite reductase, membrane component YP_089009.1 Fe-S-cluster-containing hydrogenase components 1 YP_089010.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia YP_089011.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 YP_089012.1 TPR-repeat-containing proteins YP_089013.2 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA YP_089014.1 Uncharacterized ACR YP_089015.2 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_089016.1 Dihydroneopterin aldolase YP_089017.1 Permeases of the drug/metabolite transporter (DMT) superfamily YP_089018.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_089019.2 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_089020.1 Uncharacterized ACR YP_089021.1 D-alanyl-D-alanine carboxypeptidase YP_089022.1 Lipoproteins YP_089023.1 Bacterial cell division membrane protein YP_089024.1 Cell division protein FtsI/penicillin-binding protein 2 YP_089025.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_089026.1 Uncharacterized ACR (similar to plant Iojap proteins) YP_089027.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_089028.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_089029.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_089031.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_089032.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_089033.1 Uncharacterized ACR YP_089035.1 Parvulin-like peptidyl-prolyl isomerase YP_089036.1 ATP-dependent Lon protease, bacterial type YP_089038.1 binds and unfolds substrates as part of the ClpXP protease YP_089039.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_089041.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_089042.1 Uncharacterized BCR YP_089043.1 5, 10-methylene-tetrahydrofolate dehydrogenase YP_089044.1 5, 10-methylene-tetrahydrofolate dehydrogenase YP_089046.1 Predicted metalloprotease YP_089047.1 Predicted ATPase (PP-loop superfamily), confers aluminum resistance YP_089048.1 6-pyruvoyl-tetrahydropterin synthase YP_089049.1 Organic radical activating enzymes YP_089050.1 Dihydrofolate reductase YP_089051.1 Uncharacterized BCR YP_089052.1 Uncharacterized BCR YP_089054.2 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_089055.1 FKBP-type peptidyl-prolyl cis-trans isomerases 1 YP_089056.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_089060.1 Predicted metal-binding, possibly nucleic acid-binding protein YP_089061.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_089062.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_089063.1 3-oxoacyl-acyl-carrier-protein synthase III YP_089064.1 3-oxoacyl-acyl-carrier-protein synthase III YP_089065.1 (acyl-carrier-protein) S-malonyltransferase YP_089066.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_089067.1 carries the fatty acid chain in fatty acid biosynthesis YP_089069.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_089070.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_089071.1 Xanthine/uracil permeases YP_089072.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_089073.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_089074.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_089075.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_089077.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_089080.1 NAD synthase YP_089081.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_089082.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_089083.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_089084.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_089085.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_089086.1 SAM-dependent methyltransferases YP_089087.1 Amino acid permeases YP_089088.1 Uncharacterized membrane protein YP_089089.1 Nucleoside permease YP_089091.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_089094.2 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_089095.1 Predicted membrane protein YP_089096.1 Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family YP_089097.1 Predicted hydrolases of the HAD superfamily YP_089098.1 Predicted hydrolases of the HAD superfamily YP_089100.1 Cytosine deaminase and related metal-dependent hydrolases YP_089101.1 Predicted hydrolase of alkaline phosphatase superfamily YP_089102.1 Uncharacterized BCR YP_089103.1 Nucleoid-associated protein YP_089104.1 Small protein A (tmRNA-binding) YP_089105.1 Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domain YP_089106.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors YP_089107.1 Di- and tricarboxylate transporters YP_089108.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_089109.1 Uncharacterized protein involved in fimbrial biogenesis YP_089110.1 Uncharacterized BCR YP_089111.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_089112.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_089113.1 Uncharacterized BCR YP_089114.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_089115.1 Outer membrane protein YP_089116.1 Predicted outer membrane protein YP_089117.1 Predicted membrane-associated Zn-dependent proteases 1 YP_089118.1 CDP-diglyceride synthetase YP_089119.1 Undecaprenyl pyrophosphate synthase YP_089120.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_089121.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_089122.1 Catalyzes the phosphorylation of UMP to UDP YP_089123.1 Predicted membrane-associated, metal-dependent hydrolase YP_089124.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_089125.2 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_089126.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_089127.1 Uncharacterized BCR YP_089128.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_089129.1 catalyzes the formation of dUMP from dUTP YP_089130.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_089131.1 DNA repair proteins YP_089132.1 DNA repair proteins YP_089133.1 DNA repair proteins YP_089134.2 required for 70S ribosome assembly YP_089135.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_089136.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_089137.1 Uncharacterized BCR YP_089138.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_089141.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_089142.2 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_089143.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_089144.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_089145.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_089146.1 Uncharacterized BCR YP_089148.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_089149.1 Predicted membrane protein YP_089150.1 Predicted permease YP_089151.1 Arsenate reductase and related proteins, glutaredoxin family YP_089152.1 Uncharacterized BCR YP_089154.1 ADP-heptoseLPS heptosyltransferase YP_089156.1 catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position YP_089157.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure YP_089158.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_089159.1 Site-specific DNA methylase YP_089160.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_089161.2 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_089162.1 General secretory pathway protein D YP_089167.1 Membrane carboxypeptidase (penicillin-binding protein) YP_089168.1 Uncharacterized BCR YP_089169.1 H+/gluconate symporter and related permeases YP_089170.1 Hydroxypyruvate isomerase YP_089171.1 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases YP_089172.1 Uncharacterized BCR YP_089173.1 3-hydroxyisobutyrate dehydrogenase and related proteins YP_089175.1 Transcriptional regulators of sugar metabolism YP_089176.1 catalyzes the formation of fumarate from aspartate YP_089177.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_089179.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_089180.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_089182.1 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) YP_089183.1 Sugar phosphate permease YP_089184.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic YP_089185.2 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor YP_089186.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters YP_089187.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate YP_089189.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_089190.1 Predicted ATPase with chaperone activity YP_089198.1 Transcriptional regulator YP_089199.1 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis YP_089200.1 Transcriptional regulator YP_089202.1 NADHflavin oxidoreductases, Old Yellow Enzyme family YP_089203.1 Zn-dependent hydrolases, including glyoxylases YP_089204.1 NADHflavin oxidoreductases, Old Yellow Enzyme family YP_089208.1 Predicted transposase YP_089210.1 Predicted ATPase with chaperone activity YP_089211.1 Uncharacterized membrane protein YP_089214.1 is a component of the macrolide binding site in the peptidyl transferase center YP_089215.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_089216.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_089217.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_089218.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_089219.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_089220.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_089221.1 late assembly protein YP_089222.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_089223.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_089224.1 binds 5S rRNA along with protein L5 and L25 YP_089225.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_089226.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_089227.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_089228.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_089229.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_089231.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_089232.1 one of the stabilizing components for the large ribosomal subunit YP_089233.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_089234.2 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_089235.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_089236.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_089237.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_089238.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_089239.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_089240.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_089241.2 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_089242.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis YP_089243.1 Chloride channel protein EriC YP_089244.1 Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family YP_089245.1 ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components YP_089246.1 Permeases of the major facilitator superfamily YP_089248.1 Molybdopterin-guanine dinucleotide biosynthesis protein YP_089249.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_089250.1 Uncharacterized BCR YP_089251.1 Thiol-disulfide isomerase and thioredoxins YP_089252.1 Uncharacterized BCR YP_089254.1 Uncharacterized ACR YP_089255.2 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_089256.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_089258.1 porin involved in the transport of maltose and maltodextrins YP_089259.1 with malEFG is involved in import of maltose/maltodextrin YP_089260.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_089261.1 with MalKGE is involved in maltose transport into the cell YP_089262.1 with MalKFE is involved in the transport of maltose into the cell YP_089263.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds YP_089264.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_089265.1 Glucan phosphorylase YP_089266.1 amylomaltase; acts to release glucose from maltodextrins YP_089267.1 Aldo/keto reductases, related to diketogulonate reductase YP_089271.1 Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes YP_089273.1 Superfamily II DNA helicase YP_089274.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_089276.1 Diaminopimelate decarboxylase YP_089277.1 Glutathione-S-transferases YP_089279.1 Cation/multidrug efflux pump YP_089281.1 Membrane-fusion protein YP_089283.1 Transcriptional regulators YP_089284.1 Transcriptional regulator YP_089285.1 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) YP_089286.1 Putative NADPH-quinone reductase (modulator of drug activity B) YP_089287.1 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_089288.1 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_089289.1 NADHflavin oxidoreductases, Old Yellow Enzyme family YP_089292.1 Glutathione-S-transferases YP_089293.1 Stress-induced protein YP_089294.1 Histone acetyltransferase HPA2 and related acetyltransferases YP_089295.1 Pyruvate kinase YP_089296.1 Bacterioferritin (cytochrome b1) YP_089297.1 AraC-type DNA-binding domain-containing proteins YP_089305.1 Uncharacterized ATPases of the AAA superfamily YP_089306.1 Uncharacterized BCR YP_089307.1 Nitroreductase YP_089308.1 Transcriptional regulator YP_089309.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_089310.1 Di- and tripeptidases YP_089312.1 Predicted Zn-dependent hydrolases of the beta-lactamase fold YP_089316.1 Predicted hydrolase of the alpha/beta superfamily YP_089320.1 Acetyltransferases (the isoleucine patch superfamily) YP_089321.1 Hydrolases of the alpha/beta superfamily YP_089322.1 Transcriptional regulator YP_089323.1 AraC-type DNA-binding domain-containing proteins YP_089324.1 NAD-dependent aldehyde dehydrogenases YP_089326.1 Transcriptional regulator YP_089327.1 Pirin-related protein YP_089328.1 Kef-type K+ transport systems, membrane components YP_089329.1 Predicted membrane protein YP_089330.1 Predicted membrane protein YP_089331.1 Putative NADPH-quinone reductase (modulator of drug activity B) YP_089335.1 Transcriptional regulator YP_089336.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_089337.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_089338.1 Transcriptional regulators YP_089341.1 Nitroreductase YP_089343.1 Transcriptional regulator YP_089344.1 Transcriptional regulator YP_089345.1 NADHflavin oxidoreductases, Old Yellow Enzyme family YP_089348.1 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_089350.1 Uncharacterized ACR, similar to gamma-carboxymuconolactone decarboxylase subunit YP_089353.1 Esterase/lipase YP_089354.1 Putative NADPH-quinone reductase (modulator of drug activity B) YP_089355.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_089357.1 Type I restriction-modification system methyltransferase subunit YP_089361.1 Restriction endonuclease S subunits YP_089363.1 Restriction enzymes type I helicase subunits and related helicases YP_089364.1 Hydrolases of the alpha/beta superfamily YP_089365.1 AraC-type DNA-binding domain-containing proteins YP_089366.1 Phospholipid-binding protein YP_089367.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_089368.1 Transcriptional regulator YP_089369.1 Uncharacterized BCR YP_089370.1 Phosphotransferase system, fructose-specific IIC component YP_089371.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers YP_089372.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr YP_089375.1 Rhodanese-related sulfurtransferases YP_089377.1 Uncharacterized membrane protein (similar to Drosophila rhomboid) YP_089378.1 Transcriptional regulators of sugar metabolism YP_089379.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_089380.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_089381.1 Putative translation initiation inhibitor YP_089382.1 Alcohol dehydrogenase IV YP_089384.1 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase YP_089385.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine YP_089386.1 catalyzes the formation of anthranilate from chorismate and glutamine; functions in tryptophan biosynthesis YP_089387.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_089388.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_089389.1 Uncharacterized BCR YP_089390.1 Predicted periplasmic/secreted protein YP_089391.1 FKBP-type peptidyl-prolyl cis-trans isomerases 2 YP_089393.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_089394.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_089395.1 tRNA and rRNA cytosine-C5-methylases YP_089396.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_089397.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_089398.1 Uncharacterized BCR YP_089399.1 Predicted RNA binding protein, contains S1 domain YP_089400.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_089403.1 Transcriptional regulator YP_089404.1 catalyzes the O-acetylation of serine YP_089405.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_089406.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_089407.1 Rhodanese-related sulfurtransferases YP_089408.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_089410.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_089411.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_089413.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_089414.1 Acetolactate synthase, small subunit YP_089415.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_089417.1 Predicted hydrolases of the HAD superfamily YP_089418.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_089419.1 Uncharacterized ACR YP_089420.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_089421.1 Negative regulator of sigma E activity YP_089422.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_089423.1 Positive regulator of sigma E activity YP_089424.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_089426.1 Predicted amidophosphoribosyltransferases YP_089427.1 Predicted hydrolases of the HAD superfamily YP_089428.2 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_089429.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_089431.1 Surface lipoprotein YP_089432.1 Uncharacterized ACR YP_089434.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_089435.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_089436.1 This protein performs the mismatch recognition step during the DNA repair process YP_089439.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_089440.1 Rhodanese-related sulfurtransferases YP_089441.1 negatively supercoils closed circular double-stranded DNA YP_089442.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_089444.1 Lysine efflux permease YP_089445.1 Uncharacterized BCR YP_089446.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_089449.1 Dicarboxylate-binding periplasmic protein YP_089451.1 ADP-heptoseLPS heptosyltransferase YP_089452.1 ADP-heptoseLPS heptosyltransferase YP_089453.1 Uncharacterized BCR YP_089454.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_089456.1 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) YP_089457.1 Long-chain acyl-CoA synthetases (AMP-forming) YP_089460.1 Membrane proteins related to metalloendopeptidases YP_089461.1 Membrane proteins related to metalloendopeptidases YP_089463.1 Uncharacterized membrane protein YP_089464.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_089465.1 catalyzes the modification of U13 in tRNA(Glu) YP_089466.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_089467.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_089468.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_089469.1 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit YP_089470.1 Nitrate reductase cytochrome c-type subunit YP_089471.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_089472.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway YP_089473.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_089474.1 Uncharacterized protein involved in formation of periplasmic nitrate reductase YP_089475.1 Ferredoxin 2 YP_089476.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_089477.1 Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domain YP_089478.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph YP_089479.1 membrane protein regulates uhpT expression YP_089480.1 Sensory transduction histidine kinases YP_089481.1 Sortase and related acyltransferases YP_089482.1 Glycine/D-amino acid oxidases (deaminating) YP_089484.1 Spermidine/putrescine-binding periplasmic protein YP_089485.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_089487.1 Transcriptional regulator YP_089488.1 NADHflavin oxidoreductases, Old Yellow Enzyme family YP_089490.1 Transposase YP_089491.1 Putative transposase YP_089493.1 Regulator of competence-specific genes YP_089498.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_089499.1 Uncharacterized ACR YP_089500.1 Phosphate transport regulator (distant homolog of PhoU) YP_089501.1 Phosphate transport regulator (distant homolog of PhoU) YP_089502.1 Phosphate/sulphate permeases YP_089503.1 SH3 domain protein YP_089504.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_089507.1 catalyzes the conversion of shikimate to 3-dehydroshikimate YP_089508.1 regulates genes involved in glucitol utilization YP_089510.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_089511.1 Uncharacterized BCR YP_089512.1 Membrane proteins related to metalloendopeptidases YP_089513.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_089514.1 activates the expression of the rhaBAD operon and rhaT gene YP_089515.1 AraC-type DNA-binding domain-containing proteins YP_089516.1 Uncharacterized ACR YP_089517.1 Alcohol dehydrogenase IV YP_089518.1 transports L-rhamnose and L-lyxose into the cell YP_089519.1 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases YP_089520.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_089521.1 catalyzes the ATP-dependent phosphorylation of rhamnulose YP_089522.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_089523.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_089524.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_089525.1 Small-conductance mechanosensitive channel YP_089526.1 Ferredoxin 2 YP_089527.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane YP_089528.1 DMSO reductase anchor subunit YP_089529.1 Anaerobic dehydrogenases, typically selenocysteine-containing YP_089530.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_089531.1 Selenocysteine-specific translation elongation factor YP_089532.1 Predicted periplasmic/secreted protein YP_089533.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_089534.1 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_089536.1 Predicted hydrolases of the HAD superfamily YP_089537.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_089538.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_089539.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_089540.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_089541.2 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_089542.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_089543.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_089544.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_089545.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_089546.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_089547.1 Maintains the balance of metabolites in the pentose-phosphate pathway YP_089548.1 3-Methyladenine DNA glycosylase YP_089549.1 determines N-hexane tolerance and is involved in outer membrane permeability YP_089550.1 Hydrogenase maturation factor YP_089552.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC) YP_089553.1 involved in hydrogen uptake YP_089554.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits YP_089556.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2 YP_089557.1 involved in hydrogen uptake YP_089559.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_089560.1 SAM-dependent methyltransferases YP_089561.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_089562.1 Isocitrate dehydrogenases YP_089563.1 Citrate synthase YP_089564.1 Sugar (pentulose and hexulose) kinases YP_089565.1 catalyzes the interconversion of D-xylose to D-xylulose YP_089566.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter YP_089567.1 Transcriptional regulators YP_089571.1 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB YP_089573.1 Predicted esterase of the alpha/beta hydrolase fold YP_089574.1 Na+-dependent transporters of the SNF family