-- dump date   	20140619_135503
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
221988000001	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
221988000002	MgtC family; Region: MgtC; pfam02308
221988000003	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
221988000004	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
221988000005	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
221988000006	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
221988000007	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
221988000008	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
221988000009	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
221988000010	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
221988000011	Walker A/P-loop; other site
221988000012	ATP binding site [chemical binding]; other site
221988000013	Q-loop/lid; other site
221988000014	ABC transporter signature motif; other site
221988000015	Walker B; other site
221988000016	D-loop; other site
221988000017	H-loop/switch region; other site
221988000018	Predicted flavoprotein [General function prediction only]; Region: COG0431
221988000019	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
221988000020	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
221988000021	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
221988000022	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
221988000023	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
221988000024	aspartate racemase; Region: asp_race; TIGR00035
221988000025	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
221988000026	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
221988000027	putative active site [active]
221988000028	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
221988000029	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
221988000030	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
221988000031	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
221988000032	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
221988000033	active site
221988000034	Predicted membrane protein [Function unknown]; Region: COG1297
221988000035	putative oligopeptide transporter, OPT family; Region: TIGR00733
221988000036	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
221988000037	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
221988000038	ADP-ribose binding site [chemical binding]; other site
221988000039	dimer interface [polypeptide binding]; other site
221988000040	active site
221988000041	nudix motif; other site
221988000042	metal binding site [ion binding]; metal-binding site
221988000043	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
221988000044	active site
221988000045	dimer interface [polypeptide binding]; other site
221988000046	magnesium binding site [ion binding]; other site
221988000047	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
221988000048	active site
221988000049	phosphorylation site [posttranslational modification]
221988000050	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
221988000051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
221988000052	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
221988000053	active site
221988000054	P-loop; other site
221988000055	phosphorylation site [posttranslational modification]
221988000056	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
221988000057	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
221988000058	transcriptional repressor UlaR; Provisional; Region: PRK13509
221988000059	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
221988000060	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
221988000061	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
221988000062	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
221988000063	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
221988000064	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
221988000065	DNA binding residues [nucleotide binding]
221988000066	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
221988000067	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
221988000068	gating phenylalanine in ion channel; other site
221988000069	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
221988000070	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
221988000071	FAD binding domain; Region: FAD_binding_4; pfam01565
221988000072	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
221988000073	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
221988000074	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
221988000075	putative active site [active]
221988000076	dimerization interface [polypeptide binding]; other site
221988000077	putative tRNAtyr binding site [nucleotide binding]; other site
221988000078	hypothetical protein; Reviewed; Region: PRK01637
221988000079	hypothetical protein; Provisional; Region: PRK01752
221988000080	SEC-C motif; Region: SEC-C; pfam02810
221988000081	SEC-C motif; Region: SEC-C; pfam02810
221988000082	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
221988000083	Domain of unknown function DUF87; Region: DUF87; pfam01935
221988000084	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
221988000085	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
221988000086	putative DNA binding site [nucleotide binding]; other site
221988000087	putative Zn2+ binding site [ion binding]; other site
221988000088	AsnC family; Region: AsnC_trans_reg; pfam01037
221988000089	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
221988000090	dimer interface [polypeptide binding]; other site
221988000091	active site
221988000092	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
221988000093	oxaloacetate decarboxylase; Provisional; Region: PRK14040
221988000094	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
221988000095	active site
221988000096	catalytic residues [active]
221988000097	metal binding site [ion binding]; metal-binding site
221988000098	homodimer binding site [polypeptide binding]; other site
221988000099	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
221988000100	carboxyltransferase (CT) interaction site; other site
221988000101	biotinylation site [posttranslational modification]; other site
221988000102	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
221988000103	DNA protecting protein DprA; Region: dprA; TIGR00732
221988000104	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
221988000105	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988000106	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
221988000107	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
221988000108	putative dimerization interface [polypeptide binding]; other site
221988000109	ketol-acid reductoisomerase; Validated; Region: PRK05225
221988000110	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
221988000111	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
221988000112	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
221988000113	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
221988000114	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: sgbE; PRK12347
221988000115	intersubunit interface [polypeptide binding]; other site
221988000116	active site
221988000117	Zn2+ binding site [ion binding]; other site
221988000118	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
221988000119	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
221988000120	AP (apurinic/apyrimidinic) site pocket; other site
221988000121	DNA interaction; other site
221988000122	Metal-binding active site; metal-binding site
221988000123	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
221988000124	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
221988000125	putative N- and C-terminal domain interface [polypeptide binding]; other site
221988000126	putative active site [active]
221988000127	MgATP binding site [chemical binding]; other site
221988000128	catalytic site [active]
221988000129	metal binding site [ion binding]; metal-binding site
221988000130	putative xylulose binding site [chemical binding]; other site
221988000131	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
221988000132	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
221988000133	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
221988000134	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
221988000135	DctM-like transporters; Region: DctM; pfam06808
221988000136	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
221988000137	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
221988000138	Domain of unknown function (DUF386); Region: DUF386; pfam04074
221988000139	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
221988000140	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
221988000141	Transcriptional regulator [Transcription]; Region: IclR; COG1414
221988000142	Bacterial transcriptional regulator; Region: IclR; pfam01614
221988000143	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
221988000144	active site
221988000145	dimer interface [polypeptide binding]; other site
221988000146	magnesium binding site [ion binding]; other site
221988000147	transketolase; Reviewed; Region: PRK12753
221988000148	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
221988000149	TPP-binding site [chemical binding]; other site
221988000150	dimer interface [polypeptide binding]; other site
221988000151	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
221988000152	PYR/PP interface [polypeptide binding]; other site
221988000153	dimer interface [polypeptide binding]; other site
221988000154	TPP binding site [chemical binding]; other site
221988000155	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
221988000156	L-arabinose isomerase; Provisional; Region: PRK02929
221988000157	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
221988000158	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
221988000159	trimer interface [polypeptide binding]; other site
221988000160	putative substrate binding site [chemical binding]; other site
221988000161	putative metal binding site [ion binding]; other site
221988000162	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
221988000163	putative N- and C-terminal domain interface [polypeptide binding]; other site
221988000164	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
221988000165	putative active site [active]
221988000166	MgATP binding site [chemical binding]; other site
221988000167	catalytic site [active]
221988000168	metal binding site [ion binding]; metal-binding site
221988000169	putative carbohydrate binding site [chemical binding]; other site
221988000170	MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar...; Region: MIT; cl00299
221988000171	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
221988000172	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
221988000173	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988000174	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988000175	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
221988000176	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
221988000177	TM-ABC transporter signature motif; other site
221988000178	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
221988000179	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
221988000180	Walker A/P-loop; other site
221988000181	ATP binding site [chemical binding]; other site
221988000182	Q-loop/lid; other site
221988000183	ABC transporter signature motif; other site
221988000184	Walker B; other site
221988000185	D-loop; other site
221988000186	H-loop/switch region; other site
221988000187	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
221988000188	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
221988000189	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
221988000190	ligand binding site [chemical binding]; other site
221988000191	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
221988000192	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
221988000193	active site
221988000194	metal binding site [ion binding]; metal-binding site
221988000195	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
221988000196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
221988000197	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
221988000198	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
221988000199	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
221988000200	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
221988000201	inhibitor site; inhibition site
221988000202	active site
221988000203	dimer interface [polypeptide binding]; other site
221988000204	catalytic residue [active]
221988000205	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
221988000206	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
221988000207	ligand binding site [chemical binding]; other site
221988000208	NAD binding site [chemical binding]; other site
221988000209	dimerization interface [polypeptide binding]; other site
221988000210	catalytic site [active]
221988000211	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
221988000212	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
221988000213	putative active site [active]
221988000214	metal binding site [ion binding]; metal-binding site
221988000215	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
221988000216	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
221988000217	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
221988000218	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
221988000219	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
221988000220	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
221988000221	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
221988000222	Phage Tail Collar Domain; Region: Collar; pfam07484
221988000223	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
221988000224	Baseplate J-like protein; Region: Baseplate_J; cl01294
221988000225	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
221988000226	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
221988000227	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
221988000228	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
221988000229	Phage Tail Protein X; Region: Phage_tail_X; cl02088
221988000230	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
221988000231	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
221988000232	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
221988000233	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
221988000234	Phage tail tube protein FII; Region: Phage_tube; cl01390
221988000235	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
221988000236	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
221988000237	Gp37 protein; Region: Gp37; pfam09646
221988000238	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
221988000239	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
221988000240	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
221988000241	Protein of unknown function (DUF935); Region: DUF935; pfam06074
221988000242	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
221988000243	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
221988000244	Protein of unknown function (DUF2644); Region: DUF2644; pfam10841
221988000245	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
221988000246	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
221988000247	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
221988000248	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
221988000249	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
221988000250	non-specific DNA binding site [nucleotide binding]; other site
221988000251	salt bridge; other site
221988000252	sequence-specific DNA binding site [nucleotide binding]; other site
221988000253	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
221988000254	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
221988000255	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
221988000256	Integrase core domain; Region: rve; pfam00665
221988000257	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
221988000258	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
221988000259	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988000260	Walker A/P-loop; other site
221988000261	ATP binding site [chemical binding]; other site
221988000262	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
221988000263	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
221988000264	Mor transcription activator family; Region: Mor; pfam08765
221988000265	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
221988000266	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
221988000267	RmuC family; Region: RmuC; pfam02646
221988000268	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
221988000269	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
221988000270	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
221988000271	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
221988000272	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
221988000273	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
221988000274	Coenzyme A binding pocket [chemical binding]; other site
221988000275	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
221988000276	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
221988000277	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
221988000278	shikimate binding site; other site
221988000279	NAD(P) binding site [chemical binding]; other site
221988000280	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
221988000281	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
221988000282	NAD(P) binding site [chemical binding]; other site
221988000283	TLC ATP/ADP transporter; Region: TLC; cl03940
221988000284	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
221988000285	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
221988000286	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
221988000287	Walker A/P-loop; other site
221988000288	ATP binding site [chemical binding]; other site
221988000289	Q-loop/lid; other site
221988000290	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
221988000291	ABC transporter; Region: ABC_tran_2; pfam12848
221988000292	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
221988000293	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
221988000294	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
221988000295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988000296	S-adenosylmethionine binding site [chemical binding]; other site
221988000297	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
221988000298	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
221988000299	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
221988000300	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
221988000301	P loop; other site
221988000302	GTP binding site [chemical binding]; other site
221988000303	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
221988000304	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
221988000305	putative active site [active]
221988000306	metal binding site [ion binding]; metal-binding site
221988000307	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
221988000308	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
221988000309	NADP binding site [chemical binding]; other site
221988000310	Predicted transcriptional regulators [Transcription]; Region: COG1733
221988000311	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
221988000312	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
221988000313	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
221988000314	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
221988000315	active site
221988000316	nucleophile elbow; other site
221988000317	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
221988000318	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
221988000319	NADP binding site [chemical binding]; other site
221988000320	homopentamer interface [polypeptide binding]; other site
221988000321	substrate binding site [chemical binding]; other site
221988000322	active site
221988000323	Transcriptional regulators [Transcription]; Region: PurR; COG1609
221988000324	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
221988000325	DNA binding site [nucleotide binding]
221988000326	domain linker motif; other site
221988000327	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
221988000328	putative ligand binding site [chemical binding]; other site
221988000329	putative dimerization interface [polypeptide binding]; other site
221988000330	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
221988000331	active site
221988000332	phosphorylation site [posttranslational modification]
221988000333	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
221988000334	active site
221988000335	P-loop; other site
221988000336	phosphorylation site [posttranslational modification]
221988000337	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
221988000338	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
221988000339	intersubunit interface [polypeptide binding]; other site
221988000340	active site
221988000341	catalytic residue [active]
221988000342	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
221988000343	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
221988000344	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
221988000345	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988000346	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
221988000347	dimerization interface [polypeptide binding]; other site
221988000348	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
221988000349	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
221988000350	catalytic triad [active]
221988000351	dimer interface [polypeptide binding]; other site
221988000352	Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029
221988000353	GSH binding site [chemical binding]; other site
221988000354	catalytic residues [active]
221988000355	hypothetical protein; Provisional; Region: PRK02119
221988000356	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
221988000357	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
221988000358	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
221988000359	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
221988000360	YheO-like PAS domain; Region: PAS_6; pfam08348
221988000361	HTH domain; Region: HTH_22; pfam13309
221988000362	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
221988000363	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
221988000364	DsrH like protein; Region: DsrH; cl17347
221988000365	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
221988000366	S17 interaction site [polypeptide binding]; other site
221988000367	S8 interaction site; other site
221988000368	16S rRNA interaction site [nucleotide binding]; other site
221988000369	streptomycin interaction site [chemical binding]; other site
221988000370	23S rRNA interaction site [nucleotide binding]; other site
221988000371	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
221988000372	30S ribosomal protein S7; Validated; Region: PRK05302
221988000373	elongation factor G; Reviewed; Region: PRK00007
221988000374	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
221988000375	G1 box; other site
221988000376	putative GEF interaction site [polypeptide binding]; other site
221988000377	GTP/Mg2+ binding site [chemical binding]; other site
221988000378	Switch I region; other site
221988000379	G2 box; other site
221988000380	G3 box; other site
221988000381	Switch II region; other site
221988000382	G4 box; other site
221988000383	G5 box; other site
221988000384	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
221988000385	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
221988000386	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
221988000387	elongation factor Tu; Reviewed; Region: PRK00049
221988000388	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
221988000389	G1 box; other site
221988000390	GEF interaction site [polypeptide binding]; other site
221988000391	GTP/Mg2+ binding site [chemical binding]; other site
221988000392	Switch I region; other site
221988000393	G2 box; other site
221988000394	G3 box; other site
221988000395	Switch II region; other site
221988000396	G4 box; other site
221988000397	G5 box; other site
221988000398	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
221988000399	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
221988000400	Antibiotic Binding Site [chemical binding]; other site
221988000401	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
221988000402	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
221988000403	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
221988000404	active site
221988000405	metal binding site [ion binding]; metal-binding site
221988000406	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
221988000407	non-specific DNA binding site [nucleotide binding]; other site
221988000408	salt bridge; other site
221988000409	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
221988000410	sequence-specific DNA binding site [nucleotide binding]; other site
221988000411	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
221988000412	active site
221988000413	(T/H)XGH motif; other site
221988000414	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
221988000415	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792
221988000416	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
221988000417	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
221988000418	CPxP  motif; other site
221988000419	hypothetical protein; Provisional; Region: PRK11568
221988000420	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
221988000421	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
221988000422	Cation transport protein; Region: TrkH; cl17365
221988000423	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
221988000424	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
221988000425	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
221988000426	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
221988000427	DNA binding residues [nucleotide binding]
221988000428	putative dimer interface [polypeptide binding]; other site
221988000429	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
221988000430	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
221988000431	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
221988000432	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
221988000433	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
221988000434	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
221988000435	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
221988000436	putative NADH binding site [chemical binding]; other site
221988000437	putative active site [active]
221988000438	nudix motif; other site
221988000439	putative metal binding site [ion binding]; other site
221988000440	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
221988000441	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
221988000442	substrate binding site [chemical binding]; other site
221988000443	active site
221988000444	Protein of unknown function (DUF416); Region: DUF416; cl01166
221988000445	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
221988000446	IHF dimer interface [polypeptide binding]; other site
221988000447	IHF - DNA interface [nucleotide binding]; other site
221988000448	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
221988000449	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
221988000450	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
221988000451	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
221988000452	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
221988000453	active site
221988000454	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
221988000455	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
221988000456	dimer interface [polypeptide binding]; other site
221988000457	active site
221988000458	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
221988000459	dimer interface [polypeptide binding]; other site
221988000460	active site
221988000461	benzoate transport; Region: 2A0115; TIGR00895
221988000462	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988000463	putative substrate translocation pore; other site
221988000464	Predicted membrane protein [Function unknown]; Region: COG1971
221988000465	Domain of unknown function DUF; Region: DUF204; pfam02659
221988000466	Domain of unknown function DUF; Region: DUF204; pfam02659
221988000467	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
221988000468	ATP-dependent helicase HepA; Validated; Region: PRK04914
221988000469	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
221988000470	ATP binding site [chemical binding]; other site
221988000471	putative Mg++ binding site [ion binding]; other site
221988000472	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
221988000473	nucleotide binding region [chemical binding]; other site
221988000474	ATP-binding site [chemical binding]; other site
221988000475	glutamate dehydrogenase; Provisional; Region: PRK09414
221988000476	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
221988000477	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
221988000478	NAD(P) binding site [chemical binding]; other site
221988000479	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
221988000480	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
221988000481	substrate binding site [chemical binding]; other site
221988000482	dimer interface [polypeptide binding]; other site
221988000483	ATP binding site [chemical binding]; other site
221988000484	DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337
221988000485	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
221988000486	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
221988000487	putative active site [active]
221988000488	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
221988000489	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
221988000490	TM-ABC transporter signature motif; other site
221988000491	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
221988000492	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
221988000493	Walker A/P-loop; other site
221988000494	ATP binding site [chemical binding]; other site
221988000495	Q-loop/lid; other site
221988000496	ABC transporter signature motif; other site
221988000497	Walker B; other site
221988000498	D-loop; other site
221988000499	H-loop/switch region; other site
221988000500	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
221988000501	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
221988000502	Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320
221988000503	ligand binding site [chemical binding]; other site
221988000504	dimerization interface [polypeptide binding]; other site
221988000505	zinc binding site [ion binding]; other site
221988000506	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
221988000507	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
221988000508	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988000509	S-adenosylmethionine binding site [chemical binding]; other site
221988000510	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
221988000511	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
221988000512	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
221988000513	putative homodimer interface [polypeptide binding]; other site
221988000514	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
221988000515	heterodimer interface [polypeptide binding]; other site
221988000516	homodimer interface [polypeptide binding]; other site
221988000517	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
221988000518	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
221988000519	23S rRNA interface [nucleotide binding]; other site
221988000520	L7/L12 interface [polypeptide binding]; other site
221988000521	putative thiostrepton binding site; other site
221988000522	L25 interface [polypeptide binding]; other site
221988000523	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
221988000524	mRNA/rRNA interface [nucleotide binding]; other site
221988000525	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
221988000526	23S rRNA interface [nucleotide binding]; other site
221988000527	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
221988000528	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
221988000529	core dimer interface [polypeptide binding]; other site
221988000530	peripheral dimer interface [polypeptide binding]; other site
221988000531	L10 interface [polypeptide binding]; other site
221988000532	L11 interface [polypeptide binding]; other site
221988000533	putative EF-Tu interaction site [polypeptide binding]; other site
221988000534	putative EF-G interaction site [polypeptide binding]; other site
221988000535	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
221988000536	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
221988000537	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
221988000538	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
221988000539	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
221988000540	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
221988000541	RPB1 interaction site [polypeptide binding]; other site
221988000542	RPB11 interaction site [polypeptide binding]; other site
221988000543	RPB10 interaction site [polypeptide binding]; other site
221988000544	RPB3 interaction site [polypeptide binding]; other site
221988000545	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
221988000546	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
221988000547	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
221988000548	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
221988000549	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
221988000550	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
221988000551	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
221988000552	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
221988000553	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
221988000554	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
221988000555	DNA binding site [nucleotide binding]
221988000556	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
221988000557	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
221988000558	transcription-repair coupling factor; Provisional; Region: PRK10689
221988000559	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
221988000560	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
221988000561	ATP binding site [chemical binding]; other site
221988000562	putative Mg++ binding site [ion binding]; other site
221988000563	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
221988000564	nucleotide binding region [chemical binding]; other site
221988000565	ATP-binding site [chemical binding]; other site
221988000566	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
221988000567	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
221988000568	dimer interface [polypeptide binding]; other site
221988000569	active site
221988000570	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
221988000571	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988000572	Walker A/P-loop; other site
221988000573	ATP binding site [chemical binding]; other site
221988000574	Q-loop/lid; other site
221988000575	ABC transporter signature motif; other site
221988000576	Walker B; other site
221988000577	D-loop; other site
221988000578	H-loop/switch region; other site
221988000579	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
221988000580	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
221988000581	substrate binding pocket [chemical binding]; other site
221988000582	membrane-bound complex binding site; other site
221988000583	hinge residues; other site
221988000584	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
221988000585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988000586	dimer interface [polypeptide binding]; other site
221988000587	conserved gate region; other site
221988000588	putative PBP binding loops; other site
221988000589	ABC-ATPase subunit interface; other site
221988000590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988000591	dimer interface [polypeptide binding]; other site
221988000592	conserved gate region; other site
221988000593	putative PBP binding loops; other site
221988000594	ABC-ATPase subunit interface; other site
221988000595	Haem-binding domain; Region: Haem_bd; pfam14376
221988000596	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
221988000597	Protein of unknown function (DUF423); Region: DUF423; pfam04241
221988000598	DNA polymerase I; Provisional; Region: PRK05755
221988000599	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
221988000600	active site
221988000601	metal binding site 1 [ion binding]; metal-binding site
221988000602	putative 5' ssDNA interaction site; other site
221988000603	metal binding site 3; metal-binding site
221988000604	metal binding site 2 [ion binding]; metal-binding site
221988000605	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
221988000606	putative DNA binding site [nucleotide binding]; other site
221988000607	putative metal binding site [ion binding]; other site
221988000608	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
221988000609	active site
221988000610	catalytic site [active]
221988000611	substrate binding site [chemical binding]; other site
221988000612	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
221988000613	active site
221988000614	DNA binding site [nucleotide binding]
221988000615	catalytic site [active]
221988000616	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
221988000617	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
221988000618	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988000619	FeS/SAM binding site; other site
221988000620	HemN C-terminal domain; Region: HemN_C; pfam06969
221988000621	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
221988000622	Der GTPase activator (YihI); Region: YihI; pfam04220
221988000623	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
221988000624	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
221988000625	active site
221988000626	acetylornithine deacetylase; Provisional; Region: PRK05111
221988000627	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
221988000628	metal binding site [ion binding]; metal-binding site
221988000629	putative dimer interface [polypeptide binding]; other site
221988000630	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
221988000631	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
221988000632	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
221988000633	nucleotide binding site [chemical binding]; other site
221988000634	N-acetyl-L-glutamate binding site [chemical binding]; other site
221988000635	argininosuccinate lyase; Provisional; Region: PRK04833
221988000636	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
221988000637	active sites [active]
221988000638	tetramer interface [polypeptide binding]; other site
221988000639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
221988000640	RNA methyltransferase, RsmE family; Region: TIGR00046
221988000641	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
221988000642	Recombination protein O N terminal; Region: RecO_N; pfam11967
221988000643	Recombination protein O C terminal; Region: RecO_C; pfam02565
221988000644	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
221988000645	TRAM domain; Region: TRAM; cl01282
221988000646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988000647	S-adenosylmethionine binding site [chemical binding]; other site
221988000648	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
221988000649	HD domain; Region: HD_4; pfam13328
221988000650	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
221988000651	synthetase active site [active]
221988000652	NTP binding site [chemical binding]; other site
221988000653	metal binding site [ion binding]; metal-binding site
221988000654	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
221988000655	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
221988000656	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
221988000657	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
221988000658	O-Antigen ligase; Region: Wzy_C; pfam04932
221988000659	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
221988000660	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
221988000661	active site
221988000662	intersubunit interface [polypeptide binding]; other site
221988000663	zinc binding site [ion binding]; other site
221988000664	Na+ binding site [ion binding]; other site
221988000665	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
221988000666	Phosphoglycerate kinase; Region: PGK; pfam00162
221988000667	substrate binding site [chemical binding]; other site
221988000668	hinge regions; other site
221988000669	ADP binding site [chemical binding]; other site
221988000670	catalytic site [active]
221988000671	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
221988000672	CAS motifs; other site
221988000673	active site
221988000674	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
221988000675	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
221988000676	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
221988000677	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
221988000678	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
221988000679	domain interface [polypeptide binding]; other site
221988000680	putative active site [active]
221988000681	catalytic site [active]
221988000682	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
221988000683	domain interface [polypeptide binding]; other site
221988000684	putative active site [active]
221988000685	catalytic site [active]
221988000686	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
221988000687	active site
221988000688	ribonuclease PH; Reviewed; Region: rph; PRK00173
221988000689	Ribonuclease PH; Region: RNase_PH_bact; cd11362
221988000690	hexamer interface [polypeptide binding]; other site
221988000691	active site
221988000692	hypothetical protein; Provisional; Region: PRK11820
221988000693	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
221988000694	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
221988000695	putative global regulator; Reviewed; Region: PRK09559
221988000696	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
221988000697	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
221988000698	CTP synthetase; Validated; Region: pyrG; PRK05380
221988000699	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
221988000700	Catalytic site [active]
221988000701	active site
221988000702	UTP binding site [chemical binding]; other site
221988000703	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
221988000704	active site
221988000705	putative oxyanion hole; other site
221988000706	catalytic triad [active]
221988000707	enolase; Provisional; Region: eno; PRK00077
221988000708	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
221988000709	dimer interface [polypeptide binding]; other site
221988000710	metal binding site [ion binding]; metal-binding site
221988000711	substrate binding pocket [chemical binding]; other site
221988000712	putative glutathione S-transferase; Provisional; Region: PRK10357
221988000713	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
221988000714	putative C-terminal domain interface [polypeptide binding]; other site
221988000715	putative GSH binding site (G-site) [chemical binding]; other site
221988000716	putative dimer interface [polypeptide binding]; other site
221988000717	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
221988000718	N-terminal domain interface [polypeptide binding]; other site
221988000719	dimer interface [polypeptide binding]; other site
221988000720	substrate binding pocket (H-site) [chemical binding]; other site
221988000721	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
221988000722	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
221988000723	nudix motif; other site
221988000724	Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; pfam10008
221988000725	hypothetical protein; Validated; Region: PRK00228
221988000726	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
221988000727	glutamine synthetase; Provisional; Region: glnA; PRK09469
221988000728	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
221988000729	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
221988000730	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
221988000731	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
221988000732	G1 box; other site
221988000733	putative GEF interaction site [polypeptide binding]; other site
221988000734	GTP/Mg2+ binding site [chemical binding]; other site
221988000735	Switch I region; other site
221988000736	G2 box; other site
221988000737	G3 box; other site
221988000738	Switch II region; other site
221988000739	G4 box; other site
221988000740	G5 box; other site
221988000741	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
221988000742	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
221988000743	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
221988000744	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
221988000745	catalytic triad [active]
221988000746	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
221988000747	dihydrodipicolinate synthase; Region: dapA; TIGR00674
221988000748	dimer interface [polypeptide binding]; other site
221988000749	active site
221988000750	catalytic residue [active]
221988000751	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
221988000752	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
221988000753	Coenzyme A binding pocket [chemical binding]; other site
221988000754	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
221988000755	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
221988000756	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
221988000757	active site
221988000758	HslU subunit interaction site [polypeptide binding]; other site
221988000759	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
221988000760	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988000761	Walker A motif; other site
221988000762	ATP binding site [chemical binding]; other site
221988000763	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988000764	Walker B motif; other site
221988000765	arginine finger; other site
221988000766	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
221988000767	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
221988000768	HemY protein N-terminus; Region: HemY_N; pfam07219
221988000769	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
221988000770	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
221988000771	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
221988000772	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
221988000773	active site
221988000774	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
221988000775	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
221988000776	domain interfaces; other site
221988000777	active site
221988000778	adenylate cyclase; Provisional; Region: cyaA; PRK09450
221988000779	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
221988000780	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
221988000781	transcriptional regulator NarP; Provisional; Region: PRK10403
221988000782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
221988000783	active site
221988000784	phosphorylation site [posttranslational modification]
221988000785	intermolecular recognition site; other site
221988000786	dimerization interface [polypeptide binding]; other site
221988000787	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
221988000788	DNA binding residues [nucleotide binding]
221988000789	dimerization interface [polypeptide binding]; other site
221988000790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
221988000791	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
221988000792	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
221988000793	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
221988000794	inhibitor site; inhibition site
221988000795	active site
221988000796	dimer interface [polypeptide binding]; other site
221988000797	catalytic residue [active]
221988000798	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
221988000799	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
221988000800	substrate binding site [chemical binding]; other site
221988000801	dimer interface [polypeptide binding]; other site
221988000802	ATP binding site [chemical binding]; other site
221988000803	transcriptional repressor RbsR; Provisional; Region: PRK10423
221988000804	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
221988000805	DNA binding site [nucleotide binding]
221988000806	domain linker motif; other site
221988000807	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
221988000808	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
221988000809	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
221988000810	Surface antigen; Region: Bac_surface_Ag; pfam01103
221988000811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
221988000812	Family of unknown function (DUF490); Region: DUF490; pfam04357
221988000813	exopolyphosphatase; Provisional; Region: PRK10854
221988000814	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
221988000815	TrkA-C domain; Region: TrkA_C; pfam02080
221988000816	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
221988000817	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
221988000818	TrkA-C domain; Region: TrkA_C; pfam02080
221988000819	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
221988000820	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
221988000821	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
221988000822	hybrid cluster protein; Provisional; Region: PRK05290
221988000823	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
221988000824	ACS interaction site; other site
221988000825	CODH interaction site; other site
221988000826	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
221988000827	ACS interaction site; other site
221988000828	CODH interaction site; other site
221988000829	metal cluster binding site [ion binding]; other site
221988000830	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
221988000831	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
221988000832	FAD binding pocket [chemical binding]; other site
221988000833	FAD binding motif [chemical binding]; other site
221988000834	phosphate binding motif [ion binding]; other site
221988000835	beta-alpha-beta structure motif; other site
221988000836	NAD binding pocket [chemical binding]; other site
221988000837	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
221988000838	catalytic loop [active]
221988000839	iron binding site [ion binding]; other site
221988000840	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
221988000841	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
221988000842	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
221988000843	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
221988000844	adenylosuccinate lyase; Provisional; Region: PRK09285
221988000845	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
221988000846	tetramer interface [polypeptide binding]; other site
221988000847	active site
221988000848	putative lysogenization regulator; Reviewed; Region: PRK00218
221988000849	putative acetyltransferase; Provisional; Region: PRK03624
221988000850	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
221988000851	Coenzyme A binding pocket [chemical binding]; other site
221988000852	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
221988000853	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
221988000854	Protein of unknown function (DUF539); Region: DUF539; cl01129
221988000855	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
221988000856	ApbE family; Region: ApbE; pfam02424
221988000857	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
221988000858	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
221988000859	FAD binding pocket [chemical binding]; other site
221988000860	FAD binding motif [chemical binding]; other site
221988000861	phosphate binding motif [ion binding]; other site
221988000862	beta-alpha-beta structure motif; other site
221988000863	NAD binding pocket [chemical binding]; other site
221988000864	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
221988000865	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
221988000866	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
221988000867	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
221988000868	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
221988000869	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
221988000870	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
221988000871	E3 interaction surface; other site
221988000872	lipoyl attachment site [posttranslational modification]; other site
221988000873	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
221988000874	BolA-like protein; Region: BolA; cl00386
221988000875	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
221988000876	murein transglycosylase C; Provisional; Region: mltC; PRK11671
221988000877	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
221988000878	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
221988000879	N-acetyl-D-glucosamine binding site [chemical binding]; other site
221988000880	catalytic residue [active]
221988000881	oxidative damage protection protein; Provisional; Region: PRK05408
221988000882	adenine DNA glycosylase; Provisional; Region: PRK10880
221988000883	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
221988000884	minor groove reading motif; other site
221988000885	helix-hairpin-helix signature motif; other site
221988000886	substrate binding pocket [chemical binding]; other site
221988000887	active site
221988000888	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
221988000889	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
221988000890	DNA binding and oxoG recognition site [nucleotide binding]
221988000891	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
221988000892	hypothetical protein; Provisional; Region: PRK11702
221988000893	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
221988000894	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
221988000895	Cl binding site [ion binding]; other site
221988000896	oligomer interface [polypeptide binding]; other site
221988000897	YGGT family; Region: YGGT; pfam02325
221988000898	YGGT family; Region: YGGT; pfam02325
221988000899	hypothetical protein; Validated; Region: PRK05090
221988000900	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
221988000901	triosephosphate isomerase; Provisional; Region: PRK14567
221988000902	substrate binding site [chemical binding]; other site
221988000903	dimer interface [polypeptide binding]; other site
221988000904	catalytic triad [active]
221988000905	Protein of unknown function (DUF721); Region: DUF721; cl02324
221988000906	Protein of unknown function (DUF2547); Region: DUF2547; pfam10818
221988000907	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
221988000908	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
221988000909	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
221988000910	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
221988000911	nucleotide binding region [chemical binding]; other site
221988000912	ATP-binding site [chemical binding]; other site
221988000913	SEC-C motif; Region: SEC-C; pfam02810
221988000914	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
221988000915	active site
221988000916	8-oxo-dGMP binding site [chemical binding]; other site
221988000917	nudix motif; other site
221988000918	metal binding site [ion binding]; metal-binding site
221988000919	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
221988000920	Ligand Binding Site [chemical binding]; other site
221988000921	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
221988000922	DctM-like transporters; Region: DctM; pfam06808
221988000923	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
221988000924	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
221988000925	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
221988000926	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
221988000927	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
221988000928	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
221988000929	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
221988000930	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
221988000931	substrate binding site [chemical binding]; other site
221988000932	ligand binding site [chemical binding]; other site
221988000933	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
221988000934	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
221988000935	substrate binding site [chemical binding]; other site
221988000936	GntP family permease; Region: GntP_permease; pfam02447
221988000937	fructuronate transporter; Provisional; Region: PRK10034; cl15264
221988000938	fructuronate transporter; Provisional; Region: PRK10034; cl15264
221988000939	transcriptional activator TtdR; Provisional; Region: PRK09801
221988000940	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988000941	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
221988000942	putative effector binding pocket; other site
221988000943	putative dimerization interface [polypeptide binding]; other site
221988000944	Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980
221988000945	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
221988000946	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
221988000947	HIGH motif; other site
221988000948	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
221988000949	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
221988000950	active site
221988000951	KMSKS motif; other site
221988000952	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
221988000953	tRNA binding surface [nucleotide binding]; other site
221988000954	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
221988000955	Acyltransferase family; Region: Acyl_transf_3; pfam01757
221988000956	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
221988000957	metal-binding site [ion binding]
221988000958	MerT mercuric transport protein; Region: MerT; cl03578
221988000959	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
221988000960	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
221988000961	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786
221988000962	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
221988000963	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
221988000964	active site
221988000965	tetramer interface; other site
221988000966	phosphomannomutase CpsG; Provisional; Region: PRK15414
221988000967	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
221988000968	active site
221988000969	substrate binding site [chemical binding]; other site
221988000970	metal binding site [ion binding]; metal-binding site
221988000971	carbon storage regulator; Provisional; Region: PRK01712
221988000972	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
221988000973	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
221988000974	motif 1; other site
221988000975	active site
221988000976	motif 2; other site
221988000977	motif 3; other site
221988000978	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
221988000979	DHHA1 domain; Region: DHHA1; pfam02272
221988000980	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
221988000981	Ligand Binding Site [chemical binding]; other site
221988000982	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
221988000983	MazG family protein; Region: mazG; TIGR00444
221988000984	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
221988000985	homodimer interface [polypeptide binding]; other site
221988000986	metal binding site [ion binding]; metal-binding site
221988000987	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
221988000988	homodimer interface [polypeptide binding]; other site
221988000989	active site
221988000990	putative chemical substrate binding site [chemical binding]; other site
221988000991	metal binding site [ion binding]; metal-binding site
221988000992	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
221988000993	30S subunit binding site; other site
221988000994	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
221988000995	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
221988000996	Predicted acetyltransferase [General function prediction only]; Region: COG2388
221988000997	DNA gyrase inhibitor; Reviewed; Region: PRK00418
221988000998	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
221988000999	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
221988001000	CoA-binding site [chemical binding]; other site
221988001001	ATP-binding [chemical binding]; other site
221988001002	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
221988001003	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
221988001004	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
221988001005	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
221988001006	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
221988001007	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
221988001008	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
221988001009	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
221988001010	Walker A motif; other site
221988001011	ATP binding site [chemical binding]; other site
221988001012	Walker B motif; other site
221988001013	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
221988001014	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
221988001015	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
221988001016	amidase catalytic site [active]
221988001017	Zn binding residues [ion binding]; other site
221988001018	substrate binding site [chemical binding]; other site
221988001019	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
221988001020	GTPase Era; Reviewed; Region: era; PRK00089
221988001021	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
221988001022	G1 box; other site
221988001023	GTP/Mg2+ binding site [chemical binding]; other site
221988001024	Switch I region; other site
221988001025	G2 box; other site
221988001026	Switch II region; other site
221988001027	G3 box; other site
221988001028	G4 box; other site
221988001029	G5 box; other site
221988001030	KH domain; Region: KH_2; pfam07650
221988001031	ribonuclease III; Reviewed; Region: rnc; PRK00102
221988001032	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
221988001033	dimerization interface [polypeptide binding]; other site
221988001034	active site
221988001035	metal binding site [ion binding]; metal-binding site
221988001036	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
221988001037	dsRNA binding site [nucleotide binding]; other site
221988001038	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
221988001039	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
221988001040	Catalytic site [active]
221988001041	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
221988001042	signal peptidase I; Provisional; Region: PRK10861
221988001043	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
221988001044	Catalytic site [active]
221988001045	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
221988001046	GTP-binding protein LepA; Provisional; Region: PRK05433
221988001047	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
221988001048	G1 box; other site
221988001049	putative GEF interaction site [polypeptide binding]; other site
221988001050	GTP/Mg2+ binding site [chemical binding]; other site
221988001051	Switch I region; other site
221988001052	G2 box; other site
221988001053	G3 box; other site
221988001054	Switch II region; other site
221988001055	G4 box; other site
221988001056	G5 box; other site
221988001057	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
221988001058	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
221988001059	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
221988001060	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
221988001061	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
221988001062	ligand binding site [chemical binding]; other site
221988001063	active site
221988001064	UGI interface [polypeptide binding]; other site
221988001065	catalytic site [active]
221988001066	hypothetical protein; Validated; Region: PRK02101
221988001067	Cation efflux family; Region: Cation_efflux; cl00316
221988001068	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
221988001069	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
221988001070	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
221988001071	active site
221988001072	ADP/pyrophosphate binding site [chemical binding]; other site
221988001073	dimerization interface [polypeptide binding]; other site
221988001074	allosteric effector site; other site
221988001075	fructose-1,6-bisphosphate binding site; other site
221988001076	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
221988001077	triosephosphate isomerase; Provisional; Region: PRK14565
221988001078	substrate binding site [chemical binding]; other site
221988001079	dimer interface [polypeptide binding]; other site
221988001080	catalytic triad [active]
221988001081	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
221988001082	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
221988001083	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
221988001084	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
221988001085	Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995
221988001086	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
221988001087	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
221988001088	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
221988001089	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
221988001090	putative metal dependent hydrolase; Provisional; Region: PRK11598
221988001091	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
221988001092	Sulfatase; Region: Sulfatase; pfam00884
221988001093	superoxide dismutase; Provisional; Region: PRK10925
221988001094	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
221988001095	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
221988001096	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
221988001097	Malic enzyme, N-terminal domain; Region: malic; pfam00390
221988001098	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
221988001099	putative NAD(P) binding site [chemical binding]; other site
221988001100	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
221988001101	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
221988001102	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
221988001103	RNA binding surface [nucleotide binding]; other site
221988001104	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
221988001105	active site
221988001106	uracil binding [chemical binding]; other site
221988001107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988001108	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
221988001109	putative substrate translocation pore; other site
221988001110	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
221988001111	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
221988001112	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
221988001113	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
221988001114	Walker A/P-loop; other site
221988001115	ATP binding site [chemical binding]; other site
221988001116	Q-loop/lid; other site
221988001117	ABC transporter signature motif; other site
221988001118	Walker B; other site
221988001119	D-loop; other site
221988001120	H-loop/switch region; other site
221988001121	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
221988001122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988001123	S-adenosylmethionine binding site [chemical binding]; other site
221988001124	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
221988001125	beta-hexosaminidase; Provisional; Region: PRK05337
221988001126	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
221988001127	putative dimer interface [polypeptide binding]; other site
221988001128	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
221988001129	nucleotide binding site/active site [active]
221988001130	HIT family signature motif; other site
221988001131	catalytic residue [active]
221988001132	formate transporter FocA; Region: formate_focA; TIGR04060
221988001133	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
221988001134	Pyruvate formate lyase 1; Region: PFL1; cd01678
221988001135	coenzyme A binding site [chemical binding]; other site
221988001136	active site
221988001137	catalytic residues [active]
221988001138	glycine loop; other site
221988001139	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
221988001140	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988001141	FeS/SAM binding site; other site
221988001142	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
221988001143	nucleoside/Zn binding site; other site
221988001144	dimer interface [polypeptide binding]; other site
221988001145	catalytic motif [active]
221988001146	thymidylate synthase; Reviewed; Region: thyA; PRK01827
221988001147	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
221988001148	dimerization interface [polypeptide binding]; other site
221988001149	active site
221988001150	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
221988001151	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
221988001152	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
221988001153	putative active site [active]
221988001154	Ap4A binding site [chemical binding]; other site
221988001155	nudix motif; other site
221988001156	putative metal binding site [ion binding]; other site
221988001157	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
221988001158	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
221988001159	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
221988001160	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
221988001161	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
221988001162	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
221988001163	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
221988001164	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
221988001165	active site
221988001166	P-loop; other site
221988001167	phosphorylation site [posttranslational modification]
221988001168	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
221988001169	active site
221988001170	phosphorylation site [posttranslational modification]
221988001171	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
221988001172	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
221988001173	Part of AAA domain; Region: AAA_19; pfam13245
221988001174	Family description; Region: UvrD_C_2; pfam13538
221988001175	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
221988001176	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
221988001177	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988001178	motif II; other site
221988001179	maltose O-acetyltransferase; Provisional; Region: PRK10092
221988001180	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
221988001181	active site
221988001182	substrate binding site [chemical binding]; other site
221988001183	trimer interface [polypeptide binding]; other site
221988001184	CoA binding site [chemical binding]; other site
221988001185	Predicted membrane protein [Function unknown]; Region: COG1238
221988001186	S-ribosylhomocysteinase; Provisional; Region: PRK02260
221988001187	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
221988001188	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
221988001189	ATP-grasp domain; Region: ATP-grasp; pfam02222
221988001190	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
221988001191	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
221988001192	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
221988001193	RNA/DNA hybrid binding site [nucleotide binding]; other site
221988001194	active site
221988001195	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
221988001196	transmembrane helices; other site
221988001197	TrkA-C domain; Region: TrkA_C; pfam02080
221988001198	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
221988001199	TrkA-C domain; Region: TrkA_C; pfam02080
221988001200	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
221988001201	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
221988001202	MPT binding site; other site
221988001203	trimer interface [polypeptide binding]; other site
221988001204	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
221988001205	Nitrogen regulatory protein P-II; Region: P-II; smart00938
221988001206	Cytochrome b562; Region: Cytochrom_B562; pfam07361
221988001207	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
221988001208	Domain of unknown function DUF20; Region: UPF0118; pfam01594
221988001209	disulfide bond formation protein B; Provisional; Region: PRK01749
221988001210	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
221988001211	fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812
221988001212	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
221988001213	DNA-binding site [nucleotide binding]; DNA binding site
221988001214	FadR C-terminal domain; Region: FadR_C; pfam07840
221988001215	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
221988001216	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
221988001217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988001218	dimer interface [polypeptide binding]; other site
221988001219	conserved gate region; other site
221988001220	ABC-ATPase subunit interface; other site
221988001221	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
221988001222	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
221988001223	Walker A/P-loop; other site
221988001224	ATP binding site [chemical binding]; other site
221988001225	Q-loop/lid; other site
221988001226	ABC transporter signature motif; other site
221988001227	Walker B; other site
221988001228	D-loop; other site
221988001229	H-loop/switch region; other site
221988001230	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
221988001231	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
221988001232	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988001233	active site
221988001234	motif I; other site
221988001235	motif II; other site
221988001236	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
221988001237	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
221988001238	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
221988001239	putative metal binding site; other site
221988001240	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
221988001241	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
221988001242	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
221988001243	putative active site [active]
221988001244	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
221988001245	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
221988001246	RimM N-terminal domain; Region: RimM; pfam01782
221988001247	PRC-barrel domain; Region: PRC; pfam05239
221988001248	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
221988001249	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
221988001250	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
221988001251	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
221988001252	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
221988001253	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
221988001254	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
221988001255	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
221988001256	Ligand binding site; other site
221988001257	metal-binding site
221988001258	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
221988001259	primosome assembly protein PriA; Validated; Region: PRK05580
221988001260	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
221988001261	ATP binding site [chemical binding]; other site
221988001262	putative Mg++ binding site [ion binding]; other site
221988001263	helicase superfamily c-terminal domain; Region: HELICc; smart00490
221988001264	ATP-binding site [chemical binding]; other site
221988001265	Sporulation related domain; Region: SPOR; cl10051
221988001266	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
221988001267	Sporulation related domain; Region: SPOR; pfam05036
221988001268	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
221988001269	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
221988001270	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
221988001271	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
221988001272	HlyD family secretion protein; Region: HlyD_3; pfam13437
221988001273	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
221988001274	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
221988001275	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
221988001276	roof hairpin; other site
221988001277	oligomerisation interface [polypeptide binding]; other site
221988001278	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
221988001279	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
221988001280	ring oligomerisation interface [polypeptide binding]; other site
221988001281	ATP/Mg binding site [chemical binding]; other site
221988001282	stacking interactions; other site
221988001283	hinge regions; other site
221988001284	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
221988001285	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
221988001286	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
221988001287	active site
221988001288	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
221988001289	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
221988001290	Walker A/P-loop; other site
221988001291	ATP binding site [chemical binding]; other site
221988001292	Q-loop/lid; other site
221988001293	ABC transporter signature motif; other site
221988001294	Walker B; other site
221988001295	D-loop; other site
221988001296	H-loop/switch region; other site
221988001297	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
221988001298	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
221988001299	Walker A/P-loop; other site
221988001300	ATP binding site [chemical binding]; other site
221988001301	Q-loop/lid; other site
221988001302	ABC transporter signature motif; other site
221988001303	Walker B; other site
221988001304	D-loop; other site
221988001305	H-loop/switch region; other site
221988001306	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
221988001307	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
221988001308	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988001309	dimer interface [polypeptide binding]; other site
221988001310	conserved gate region; other site
221988001311	putative PBP binding loops; other site
221988001312	ABC-ATPase subunit interface; other site
221988001313	nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789
221988001314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988001315	dimer interface [polypeptide binding]; other site
221988001316	conserved gate region; other site
221988001317	putative PBP binding loops; other site
221988001318	ABC-ATPase subunit interface; other site
221988001319	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
221988001320	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
221988001321	substrate binding site [chemical binding]; other site
221988001322	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988001323	S-adenosylmethionine binding site [chemical binding]; other site
221988001324	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
221988001325	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
221988001326	DNA binding residues [nucleotide binding]
221988001327	dimer interface [polypeptide binding]; other site
221988001328	putative metal binding site [ion binding]; other site
221988001329	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
221988001330	primosomal replication protein N; Provisional; Region: PRK02801
221988001331	generic binding surface I; other site
221988001332	generic binding surface II; other site
221988001333	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
221988001334	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
221988001335	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
221988001336	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
221988001337	exoribonuclease R; Provisional; Region: PRK11642
221988001338	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
221988001339	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
221988001340	RNB domain; Region: RNB; pfam00773
221988001341	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
221988001342	RNA binding site [nucleotide binding]; other site
221988001343	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
221988001344	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
221988001345	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
221988001346	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
221988001347	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
221988001348	Cell division protein ZapA; Region: ZapA; pfam05164
221988001349	hypothetical protein; Reviewed; Region: PRK01736
221988001350	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
221988001351	proline aminopeptidase P II; Provisional; Region: PRK10879
221988001352	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
221988001353	active site
221988001354	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
221988001355	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
221988001356	trmE is a tRNA modification GTPase; Region: trmE; cd04164
221988001357	G1 box; other site
221988001358	GTP/Mg2+ binding site [chemical binding]; other site
221988001359	Switch I region; other site
221988001360	G2 box; other site
221988001361	Switch II region; other site
221988001362	G3 box; other site
221988001363	G4 box; other site
221988001364	G5 box; other site
221988001365	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
221988001366	membrane protein insertase; Provisional; Region: PRK01318
221988001367	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
221988001368	hypothetical protein; Validated; Region: PRK00041
221988001369	ribonuclease P; Reviewed; Region: rnpA; PRK01732
221988001370	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
221988001371	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
221988001372	DnaA N-terminal domain; Region: DnaA_N; pfam11638
221988001373	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988001374	Walker A motif; other site
221988001375	ATP binding site [chemical binding]; other site
221988001376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
221988001377	Walker B motif; other site
221988001378	arginine finger; other site
221988001379	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
221988001380	DnaA box-binding interface [nucleotide binding]; other site
221988001381	DNA polymerase III subunit beta; Validated; Region: PRK05643
221988001382	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
221988001383	putative DNA binding surface [nucleotide binding]; other site
221988001384	dimer interface [polypeptide binding]; other site
221988001385	beta-clamp/clamp loader binding surface; other site
221988001386	beta-clamp/translesion DNA polymerase binding surface; other site
221988001387	recF protein; Region: recf; TIGR00611
221988001388	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988001389	Walker A/P-loop; other site
221988001390	ATP binding site [chemical binding]; other site
221988001391	Q-loop/lid; other site
221988001392	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988001393	ABC transporter signature motif; other site
221988001394	Walker B; other site
221988001395	D-loop; other site
221988001396	H-loop/switch region; other site
221988001397	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
221988001398	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
221988001399	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
221988001400	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
221988001401	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
221988001402	HIGH motif; other site
221988001403	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
221988001404	active site
221988001405	KMSKS motif; other site
221988001406	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
221988001407	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
221988001408	RNase E interface [polypeptide binding]; other site
221988001409	trimer interface [polypeptide binding]; other site
221988001410	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
221988001411	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
221988001412	RNase E interface [polypeptide binding]; other site
221988001413	trimer interface [polypeptide binding]; other site
221988001414	active site
221988001415	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
221988001416	putative nucleic acid binding region [nucleotide binding]; other site
221988001417	G-X-X-G motif; other site
221988001418	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
221988001419	RNA binding site [nucleotide binding]; other site
221988001420	domain interface; other site
221988001421	lipoprotein NlpI; Provisional; Region: PRK11189
221988001422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
221988001423	binding surface
221988001424	TPR motif; other site
221988001425	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
221988001426	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
221988001427	ATP binding site [chemical binding]; other site
221988001428	Mg++ binding site [ion binding]; other site
221988001429	motif III; other site
221988001430	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
221988001431	nucleotide binding region [chemical binding]; other site
221988001432	ATP-binding site [chemical binding]; other site
221988001433	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
221988001434	putative RNA binding site [nucleotide binding]; other site
221988001435	putative transporter; Provisional; Region: PRK11660
221988001436	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
221988001437	Sulfate transporter family; Region: Sulfate_transp; pfam00916
221988001438	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
221988001439	hypothetical protein; Provisional; Region: PRK11212
221988001440	benzoate transport; Region: 2A0115; TIGR00895
221988001441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988001442	putative substrate translocation pore; other site
221988001443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988001444	twin arginine translocase protein A; Provisional; Region: tatA; PRK01833
221988001445	sec-independent translocase; Provisional; Region: PRK01770
221988001446	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
221988001447	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
221988001448	dimer interface [polypeptide binding]; other site
221988001449	allosteric magnesium binding site [ion binding]; other site
221988001450	active site
221988001451	aspartate-rich active site metal binding site; other site
221988001452	Schiff base residues; other site
221988001453	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
221988001454	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
221988001455	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
221988001456	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988001457	FeS/SAM binding site; other site
221988001458	elongation factor P; Validated; Region: PRK00529
221988001459	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
221988001460	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
221988001461	RNA binding site [nucleotide binding]; other site
221988001462	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
221988001463	RNA binding site [nucleotide binding]; other site
221988001464	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
221988001465	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
221988001466	putative active site [active]
221988001467	putative metal binding site [ion binding]; other site
221988001468	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
221988001469	putative acyl-acceptor binding pocket; other site
221988001470	FtsI repressor; Provisional; Region: PRK10883
221988001471	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
221988001472	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
221988001473	Protein of unknown function (DUF554); Region: DUF554; pfam04474
221988001474	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
221988001475	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
221988001476	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
221988001477	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
221988001478	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
221988001479	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
221988001480	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
221988001481	N-terminal plug; other site
221988001482	ligand-binding site [chemical binding]; other site
221988001483	hypothetical protein; Provisional; Region: PRK11573
221988001484	Domain of unknown function DUF21; Region: DUF21; pfam01595
221988001485	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
221988001486	Transporter associated domain; Region: CorC_HlyC; smart01091
221988001487	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
221988001488	signal recognition particle protein; Provisional; Region: PRK10867
221988001489	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
221988001490	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
221988001491	P loop; other site
221988001492	GTP binding site [chemical binding]; other site
221988001493	Signal peptide binding domain; Region: SRP_SPB; pfam02978
221988001494	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
221988001495	Sodium Bile acid symporter family; Region: SBF; pfam01758
221988001496	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
221988001497	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988001498	motif II; other site
221988001499	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
221988001500	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
221988001501	active site
221988001502	Int/Topo IB signature motif; other site
221988001503	Transcriptional regulators [Transcription]; Region: GntR; COG1802
221988001504	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
221988001505	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
221988001506	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
221988001507	putative NAD(P) binding site [chemical binding]; other site
221988001508	catalytic Zn binding site [ion binding]; other site
221988001509	structural Zn binding site [ion binding]; other site
221988001510	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
221988001511	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
221988001512	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
221988001513	DctM-like transporters; Region: DctM; pfam06808
221988001514	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
221988001515	altronate oxidoreductase; Provisional; Region: PRK03643
221988001516	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
221988001517	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
221988001518	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
221988001519	galactarate dehydratase; Region: galactar-dH20; TIGR03248
221988001520	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
221988001521	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
221988001522	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
221988001523	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
221988001524	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
221988001525	FMN binding site [chemical binding]; other site
221988001526	active site
221988001527	catalytic residues [active]
221988001528	substrate binding site [chemical binding]; other site
221988001529	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
221988001530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
221988001531	EamA-like transporter family; Region: EamA; pfam00892
221988001532	mannonate dehydratase; Provisional; Region: PRK03906
221988001533	mannonate dehydratase; Region: uxuA; TIGR00695
221988001534	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
221988001535	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
221988001536	DNA-binding site [nucleotide binding]; DNA binding site
221988001537	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
221988001538	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
221988001539	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
221988001540	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
221988001541	putative active site [active]
221988001542	putative catalytic site [active]
221988001543	DctM-like transporters; Region: DctM; pfam06808
221988001544	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
221988001545	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
221988001546	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
221988001547	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
221988001548	membrane-bound complex binding site; other site
221988001549	hinge residues; other site
221988001550	D-mannonate oxidoreductase; Provisional; Region: PRK08277
221988001551	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
221988001552	putative NAD(P) binding site [chemical binding]; other site
221988001553	active site
221988001554	Glucuronate isomerase; Region: UxaC; pfam02614
221988001555	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
221988001556	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
221988001557	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
221988001558	substrate binding site [chemical binding]; other site
221988001559	ATP binding site [chemical binding]; other site
221988001560	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
221988001561	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
221988001562	active site
221988001563	intersubunit interface [polypeptide binding]; other site
221988001564	catalytic residue [active]
221988001565	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
221988001566	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
221988001567	active site
221988001568	metal binding site [ion binding]; metal-binding site
221988001569	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
221988001570	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
221988001571	Walker A/P-loop; other site
221988001572	ATP binding site [chemical binding]; other site
221988001573	Q-loop/lid; other site
221988001574	ABC transporter signature motif; other site
221988001575	Walker B; other site
221988001576	D-loop; other site
221988001577	H-loop/switch region; other site
221988001578	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
221988001579	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
221988001580	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988001581	dimer interface [polypeptide binding]; other site
221988001582	conserved gate region; other site
221988001583	putative PBP binding loops; other site
221988001584	ABC-ATPase subunit interface; other site
221988001585	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
221988001586	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
221988001587	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
221988001588	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
221988001589	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
221988001590	GTP-binding protein YchF; Reviewed; Region: PRK09601
221988001591	YchF GTPase; Region: YchF; cd01900
221988001592	G1 box; other site
221988001593	GTP/Mg2+ binding site [chemical binding]; other site
221988001594	Switch I region; other site
221988001595	G2 box; other site
221988001596	Switch II region; other site
221988001597	G3 box; other site
221988001598	G4 box; other site
221988001599	G5 box; other site
221988001600	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
221988001601	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
221988001602	putative active site [active]
221988001603	catalytic residue [active]
221988001604	Predicted membrane protein [Function unknown]; Region: COG2510
221988001605	hypothetical protein; Validated; Region: PRK01777
221988001606	Uncharacterized conserved protein [Function unknown]; Region: COG2850
221988001607	Cupin-like domain; Region: Cupin_8; pfam13621
221988001608	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
221988001609	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
221988001610	generic binding surface II; other site
221988001611	generic binding surface I; other site
221988001612	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
221988001613	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
221988001614	trimer interface [polypeptide binding]; other site
221988001615	eyelet of channel; other site
221988001616	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
221988001617	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
221988001618	Bacterial transcriptional regulator; Region: IclR; pfam01614
221988001619	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
221988001620	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
221988001621	NADP binding site [chemical binding]; other site
221988001622	homodimer interface [polypeptide binding]; other site
221988001623	active site
221988001624	hypothetical protein; Provisional; Region: PRK09273
221988001625	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
221988001626	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
221988001627	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
221988001628	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
221988001629	substrate binding site [chemical binding]; other site
221988001630	ATP binding site [chemical binding]; other site
221988001631	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
221988001632	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
221988001633	active site
221988001634	intersubunit interface [polypeptide binding]; other site
221988001635	catalytic residue [active]
221988001636	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
221988001637	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
221988001638	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
221988001639	dimerization interface [polypeptide binding]; other site
221988001640	thymidylate kinase; Validated; Region: tmk; PRK00698
221988001641	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
221988001642	TMP-binding site; other site
221988001643	ATP-binding site [chemical binding]; other site
221988001644	DNA polymerase III subunit delta'; Validated; Region: PRK06871
221988001645	DNA polymerase III subunit delta'; Validated; Region: PRK08485
221988001646	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
221988001647	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
221988001648	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
221988001649	active site
221988001650	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
221988001651	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
221988001652	Domain of unknown function DUF21; Region: DUF21; pfam01595
221988001653	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
221988001654	Transporter associated domain; Region: CorC_HlyC; smart01091
221988001655	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
221988001656	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
221988001657	putative active site [active]
221988001658	putative PHP Thumb interface [polypeptide binding]; other site
221988001659	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
221988001660	generic binding surface I; other site
221988001661	generic binding surface II; other site
221988001662	xanthine permease; Region: pbuX; TIGR03173
221988001663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
221988001664	Predicted permeases [General function prediction only]; Region: RarD; COG2962
221988001665	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
221988001666	hypothetical protein; Provisional; Region: PRK11622
221988001667	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
221988001668	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
221988001669	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988001670	dimer interface [polypeptide binding]; other site
221988001671	conserved gate region; other site
221988001672	putative PBP binding loops; other site
221988001673	ABC-ATPase subunit interface; other site
221988001674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988001675	dimer interface [polypeptide binding]; other site
221988001676	conserved gate region; other site
221988001677	putative PBP binding loops; other site
221988001678	ABC-ATPase subunit interface; other site
221988001679	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
221988001680	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988001681	Walker A/P-loop; other site
221988001682	ATP binding site [chemical binding]; other site
221988001683	Q-loop/lid; other site
221988001684	ABC transporter signature motif; other site
221988001685	Walker B; other site
221988001686	D-loop; other site
221988001687	H-loop/switch region; other site
221988001688	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
221988001689	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
221988001690	dimer interface [polypeptide binding]; other site
221988001691	ssDNA binding site [nucleotide binding]; other site
221988001692	tetramer (dimer of dimers) interface [polypeptide binding]; other site
221988001693	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
221988001694	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
221988001695	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
221988001696	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
221988001697	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
221988001698	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
221988001699	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
221988001700	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
221988001701	molybdopterin cofactor binding site [chemical binding]; other site
221988001702	substrate binding site [chemical binding]; other site
221988001703	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
221988001704	molybdopterin cofactor binding site; other site
221988001705	rod shape-determining protein MreB; Provisional; Region: PRK13927
221988001706	MreB and similar proteins; Region: MreB_like; cd10225
221988001707	nucleotide binding site [chemical binding]; other site
221988001708	Mg binding site [ion binding]; other site
221988001709	putative protofilament interaction site [polypeptide binding]; other site
221988001710	RodZ interaction site [polypeptide binding]; other site
221988001711	rod shape-determining protein MreC; Region: mreC; TIGR00219
221988001712	rod shape-determining protein MreC; Region: MreC; pfam04085
221988001713	rod shape-determining protein MreD; Region: MreD; cl01087
221988001714	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
221988001715	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
221988001716	active site
221988001717	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
221988001718	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
221988001719	substrate binding site [chemical binding]; other site
221988001720	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
221988001721	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
221988001722	substrate binding site [chemical binding]; other site
221988001723	ligand binding site [chemical binding]; other site
221988001724	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
221988001725	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
221988001726	putative metal binding site [ion binding]; other site
221988001727	tartrate dehydrogenase; Region: TTC; TIGR02089
221988001728	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
221988001729	2-isopropylmalate synthase; Validated; Region: PRK00915
221988001730	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
221988001731	active site
221988001732	catalytic residues [active]
221988001733	metal binding site [ion binding]; metal-binding site
221988001734	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
221988001735	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
221988001736	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988001737	Walker A/P-loop; other site
221988001738	ATP binding site [chemical binding]; other site
221988001739	Q-loop/lid; other site
221988001740	ABC transporter signature motif; other site
221988001741	Walker B; other site
221988001742	D-loop; other site
221988001743	H-loop/switch region; other site
221988001744	heme exporter protein CcmB; Region: ccmB; TIGR01190
221988001745	heme exporter protein CcmC; Region: ccmC; TIGR01191
221988001746	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
221988001747	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
221988001748	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
221988001749	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
221988001750	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
221988001751	catalytic residues [active]
221988001752	central insert; other site
221988001753	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
221988001754	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
221988001755	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
221988001756	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
221988001757	TPR motif; other site
221988001758	binding surface
221988001759	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
221988001760	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
221988001761	putative metal binding site [ion binding]; other site
221988001762	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
221988001763	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
221988001764	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
221988001765	Protein of unknown function (DUF986); Region: DUF986; pfam06173
221988001766	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
221988001767	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
221988001768	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
221988001769	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
221988001770	active pocket/dimerization site; other site
221988001771	active site
221988001772	phosphorylation site [posttranslational modification]
221988001773	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
221988001774	active site
221988001775	phosphorylation site [posttranslational modification]
221988001776	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
221988001777	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
221988001778	PhnA protein; Region: PhnA; pfam03831
221988001779	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
221988001780	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
221988001781	putative active site [active]
221988001782	putative dimer interface [polypeptide binding]; other site
221988001783	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
221988001784	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
221988001785	active site
221988001786	HIGH motif; other site
221988001787	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
221988001788	KMSKS motif; other site
221988001789	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
221988001790	tRNA binding surface [nucleotide binding]; other site
221988001791	anticodon binding site; other site
221988001792	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
221988001793	substrate binding site [chemical binding]; other site
221988001794	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
221988001795	substrate binding site [chemical binding]; other site
221988001796	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
221988001797	active site
221988001798	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
221988001799	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
221988001800	dimerization interface [polypeptide binding]; other site
221988001801	putative ATP binding site [chemical binding]; other site
221988001802	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
221988001803	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
221988001804	active site
221988001805	substrate binding site [chemical binding]; other site
221988001806	cosubstrate binding site; other site
221988001807	catalytic site [active]
221988001808	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
221988001809	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
221988001810	active site
221988001811	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
221988001812	SurA N-terminal domain; Region: SurA_N; pfam09312
221988001813	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
221988001814	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
221988001815	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
221988001816	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
221988001817	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
221988001818	active site
221988001819	metal binding site [ion binding]; metal-binding site
221988001820	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
221988001821	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988001822	FeS/SAM binding site; other site
221988001823	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
221988001824	ATP cone domain; Region: ATP-cone; pfam03477
221988001825	Class III ribonucleotide reductase; Region: RNR_III; cd01675
221988001826	effector binding site; other site
221988001827	active site
221988001828	Zn binding site [ion binding]; other site
221988001829	glycine loop; other site
221988001830	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
221988001831	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
221988001832	putative DNA-binding cleft [nucleotide binding]; other site
221988001833	putative DNA clevage site; other site
221988001834	molecular lever; other site
221988001835	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
221988001836	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
221988001837	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
221988001838	DNA binding site [nucleotide binding]
221988001839	active site
221988001840	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
221988001841	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
221988001842	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
221988001843	ligand binding site [chemical binding]; other site
221988001844	calcium binding site [ion binding]; other site
221988001845	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
221988001846	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
221988001847	TM-ABC transporter signature motif; other site
221988001848	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
221988001849	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
221988001850	Walker A/P-loop; other site
221988001851	ATP binding site [chemical binding]; other site
221988001852	Q-loop/lid; other site
221988001853	ABC transporter signature motif; other site
221988001854	Walker B; other site
221988001855	D-loop; other site
221988001856	H-loop/switch region; other site
221988001857	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
221988001858	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
221988001859	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
221988001860	ligand binding site [chemical binding]; other site
221988001861	calcium binding site [ion binding]; other site
221988001862	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
221988001863	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
221988001864	DNA binding site [nucleotide binding]
221988001865	domain linker motif; other site
221988001866	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
221988001867	ligand binding site [chemical binding]; other site
221988001868	dimerization interface (closed form) [polypeptide binding]; other site
221988001869	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
221988001870	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
221988001871	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
221988001872	dimer interface [polypeptide binding]; other site
221988001873	active site
221988001874	galactokinase; Provisional; Region: PRK05101
221988001875	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
221988001876	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
221988001877	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
221988001878	active site
221988001879	catalytic residues [active]
221988001880	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
221988001881	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
221988001882	Transporter associated domain; Region: CorC_HlyC; smart01091
221988001883	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
221988001884	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
221988001885	putative active site [active]
221988001886	catalytic triad [active]
221988001887	putative dimer interface [polypeptide binding]; other site
221988001888	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
221988001889	rRNA binding site [nucleotide binding]; other site
221988001890	predicted 30S ribosome binding site; other site
221988001891	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
221988001892	Chain length determinant protein; Region: Wzz; cl15801
221988001893	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
221988001894	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
221988001895	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
221988001896	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
221988001897	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
221988001898	active site
221988001899	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
221988001900	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
221988001901	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
221988001902	UDP-galactopyranose mutase; Region: GLF; pfam03275
221988001903	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
221988001904	Bacterial sugar transferase; Region: Bac_transf; pfam02397
221988001905	Predicted membrane protein [Function unknown]; Region: COG2246
221988001906	GtrA-like protein; Region: GtrA; pfam04138
221988001907	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
221988001908	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
221988001909	Ligand binding site; other site
221988001910	Putative Catalytic site; other site
221988001911	DXD motif; other site
221988001912	aminopeptidase B; Provisional; Region: PRK05015
221988001913	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
221988001914	interface (dimer of trimers) [polypeptide binding]; other site
221988001915	Substrate-binding/catalytic site; other site
221988001916	Zn-binding sites [ion binding]; other site
221988001917	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
221988001918	active site
221988001919	multimer interface [polypeptide binding]; other site
221988001920	S-adenosylmethionine synthetase; Validated; Region: PRK05250
221988001921	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
221988001922	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
221988001923	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
221988001924	Ferritin-like domain; Region: Ferritin; pfam00210
221988001925	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
221988001926	dimerization interface [polypeptide binding]; other site
221988001927	DPS ferroxidase diiron center [ion binding]; other site
221988001928	ion pore; other site
221988001929	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
221988001930	CHAP domain; Region: CHAP; pfam05257
221988001931	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
221988001932	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
221988001933	ArsC family; Region: ArsC; pfam03960
221988001934	putative catalytic residues [active]
221988001935	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
221988001936	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
221988001937	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
221988001938	metal binding site [ion binding]; metal-binding site
221988001939	dimer interface [polypeptide binding]; other site
221988001940	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
221988001941	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
221988001942	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
221988001943	thiamine phosphate binding site [chemical binding]; other site
221988001944	active site
221988001945	pyrophosphate binding site [ion binding]; other site
221988001946	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
221988001947	dimer interface [polypeptide binding]; other site
221988001948	substrate binding site [chemical binding]; other site
221988001949	ATP binding site [chemical binding]; other site
221988001950	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
221988001951	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
221988001952	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
221988001953	FAD binding pocket [chemical binding]; other site
221988001954	FAD binding motif [chemical binding]; other site
221988001955	phosphate binding motif [ion binding]; other site
221988001956	beta-alpha-beta structure motif; other site
221988001957	NAD binding pocket [chemical binding]; other site
221988001958	hypothetical protein; Provisional; Region: PRK05255
221988001959	peptidase PmbA; Provisional; Region: PRK11040
221988001960	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
221988001961	active site
221988001962	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
221988001963	Strictosidine synthase; Region: Str_synth; pfam03088
221988001964	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
221988001965	fructuronate transporter; Provisional; Region: PRK10034; cl15264
221988001966	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
221988001967	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
221988001968	active site
221988001969	catalytic tetrad [active]
221988001970	GntP family permease; Region: GntP_permease; pfam02447
221988001971	fructuronate transporter; Provisional; Region: PRK10034; cl15264
221988001972	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
221988001973	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
221988001974	active site
221988001975	tetramer interface [polypeptide binding]; other site
221988001976	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
221988001977	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
221988001978	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
221988001979	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
221988001980	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
221988001981	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
221988001982	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
221988001983	galactarate dehydratase; Region: galactar-dH20; TIGR03248
221988001984	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
221988001985	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
221988001986	DctM-like transporters; Region: DctM; pfam06808
221988001987	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
221988001988	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
221988001989	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
221988001990	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
221988001991	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
221988001992	16S/18S rRNA binding site [nucleotide binding]; other site
221988001993	S13e-L30e interaction site [polypeptide binding]; other site
221988001994	25S rRNA binding site [nucleotide binding]; other site
221988001995	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
221988001996	Predicted permease [General function prediction only]; Region: COG2056
221988001997	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
221988001998	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
221988001999	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
221988002000	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
221988002001	dimer interface [polypeptide binding]; other site
221988002002	catalytic site [active]
221988002003	putative active site [active]
221988002004	putative substrate binding site [chemical binding]; other site
221988002005	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
221988002006	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
221988002007	dimer interface [polypeptide binding]; other site
221988002008	active site
221988002009	metal binding site [ion binding]; metal-binding site
221988002010	glutathione binding site [chemical binding]; other site
221988002011	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
221988002012	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
221988002013	substrate binding pocket [chemical binding]; other site
221988002014	membrane-bound complex binding site; other site
221988002015	hinge residues; other site
221988002016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988002017	S-adenosylmethionine binding site [chemical binding]; other site
221988002018	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
221988002019	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
221988002020	dimer interface [polypeptide binding]; other site
221988002021	anticodon binding site; other site
221988002022	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
221988002023	homodimer interface [polypeptide binding]; other site
221988002024	motif 1; other site
221988002025	active site
221988002026	motif 2; other site
221988002027	GAD domain; Region: GAD; pfam02938
221988002028	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
221988002029	active site
221988002030	motif 3; other site
221988002031	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
221988002032	nudix motif; other site
221988002033	hypothetical protein; Validated; Region: PRK00110
221988002034	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
221988002035	active site
221988002036	putative DNA-binding cleft [nucleotide binding]; other site
221988002037	dimer interface [polypeptide binding]; other site
221988002038	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
221988002039	RuvA N terminal domain; Region: RuvA_N; pfam01330
221988002040	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
221988002041	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
221988002042	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988002043	Walker A motif; other site
221988002044	ATP binding site [chemical binding]; other site
221988002045	Walker B motif; other site
221988002046	arginine finger; other site
221988002047	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
221988002048	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
221988002049	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
221988002050	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
221988002051	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
221988002052	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
221988002053	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600
221988002054	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
221988002055	active site
221988002056	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
221988002057	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
221988002058	colicin uptake protein TolR; Provisional; Region: PRK11024
221988002059	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
221988002060	TolA C-terminal; Region: TolA; pfam06519
221988002061	translocation protein TolB; Provisional; Region: tolB; PRK01742
221988002062	TolB amino-terminal domain; Region: TolB_N; pfam04052
221988002063	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
221988002064	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
221988002065	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
221988002066	similar to outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins
221988002067	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
221988002068	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
221988002069	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
221988002070	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
221988002071	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
221988002072	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
221988002073	DNA topoisomerase III; Provisional; Region: PRK07726
221988002074	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
221988002075	active site
221988002076	putative interdomain interaction site [polypeptide binding]; other site
221988002077	putative metal-binding site [ion binding]; other site
221988002078	putative nucleotide binding site [chemical binding]; other site
221988002079	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
221988002080	domain I; other site
221988002081	DNA binding groove [nucleotide binding]
221988002082	phosphate binding site [ion binding]; other site
221988002083	domain II; other site
221988002084	domain III; other site
221988002085	nucleotide binding site [chemical binding]; other site
221988002086	catalytic site [active]
221988002087	domain IV; other site
221988002088	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
221988002089	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
221988002090	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
221988002091	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
221988002092	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
221988002093	catalytic loop [active]
221988002094	iron binding site [ion binding]; other site
221988002095	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
221988002096	4Fe-4S binding domain; Region: Fer4; pfam00037
221988002097	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
221988002098	[4Fe-4S] binding site [ion binding]; other site
221988002099	molybdopterin cofactor binding site; other site
221988002100	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
221988002101	molybdopterin cofactor binding site; other site
221988002102	GTP-binding protein Der; Reviewed; Region: PRK00093
221988002103	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
221988002104	G1 box; other site
221988002105	GTP/Mg2+ binding site [chemical binding]; other site
221988002106	Switch I region; other site
221988002107	G2 box; other site
221988002108	Switch II region; other site
221988002109	G3 box; other site
221988002110	G4 box; other site
221988002111	G5 box; other site
221988002112	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
221988002113	G1 box; other site
221988002114	GTP/Mg2+ binding site [chemical binding]; other site
221988002115	Switch I region; other site
221988002116	G2 box; other site
221988002117	G3 box; other site
221988002118	Switch II region; other site
221988002119	G4 box; other site
221988002120	G5 box; other site
221988002121	YciI-like protein; Reviewed; Region: PRK11370
221988002122	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
221988002123	intracellular septation protein A; Reviewed; Region: PRK00259
221988002124	OmpW family; Region: OmpW; cl17427
221988002125	recombination and repair protein; Provisional; Region: PRK10869
221988002126	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
221988002127	Walker A/P-loop; other site
221988002128	ATP binding site [chemical binding]; other site
221988002129	Q-loop/lid; other site
221988002130	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
221988002131	ABC transporter signature motif; other site
221988002132	Walker B; other site
221988002133	D-loop; other site
221988002134	H-loop/switch region; other site
221988002135	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
221988002136	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
221988002137	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
221988002138	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
221988002139	dimer interface [polypeptide binding]; other site
221988002140	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
221988002141	LexA repressor; Validated; Region: PRK00215
221988002142	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
221988002143	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
221988002144	Catalytic site [active]
221988002145	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
221988002146	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
221988002147	putative acyl-acceptor binding pocket; other site
221988002148	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
221988002149	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
221988002150	active site
221988002151	Int/Topo IB signature motif; other site
221988002152	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
221988002153	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
221988002154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988002155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988002156	S-adenosylmethionine binding site [chemical binding]; other site
221988002157	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
221988002158	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
221988002159	trimer interface [polypeptide binding]; other site
221988002160	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
221988002161	trimer interface [polypeptide binding]; other site
221988002162	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
221988002163	trimer interface [polypeptide binding]; other site
221988002164	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
221988002165	trimer interface [polypeptide binding]; other site
221988002166	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
221988002167	trimer interface [polypeptide binding]; other site
221988002168	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
221988002169	trimer interface [polypeptide binding]; other site
221988002170	YadA-like C-terminal region; Region: YadA; pfam03895
221988002171	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
221988002172	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
221988002173	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
221988002174	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
221988002175	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
221988002176	Uncharacterized conserved protein [Function unknown]; Region: COG1556
221988002177	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
221988002178	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
221988002179	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
221988002180	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
221988002181	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
221988002182	Cysteine-rich domain; Region: CCG; pfam02754
221988002183	Cysteine-rich domain; Region: CCG; pfam02754
221988002184	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
221988002185	L-lactate permease; Region: Lactate_perm; cl00701
221988002186	N-acetylglutamate synthase; Validated; Region: PRK05279
221988002187	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
221988002188	putative feedback inhibition sensing region; other site
221988002189	putative nucleotide binding site [chemical binding]; other site
221988002190	putative substrate binding site [chemical binding]; other site
221988002191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
221988002192	Coenzyme A binding pocket [chemical binding]; other site
221988002193	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
221988002194	GSH binding site [chemical binding]; other site
221988002195	catalytic residues [active]
221988002196	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
221988002197	dimer interface [polypeptide binding]; other site
221988002198	FMN binding site [chemical binding]; other site
221988002199	NADPH bind site [chemical binding]; other site
221988002200	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
221988002201	ATP-grasp domain; Region: ATP-grasp_4; cl17255
221988002202	hypothetical protein; Provisional; Region: PRK04940
221988002203	fumarate hydratase; Reviewed; Region: fumC; PRK00485
221988002204	Class II fumarases; Region: Fumarase_classII; cd01362
221988002205	active site
221988002206	tetramer interface [polypeptide binding]; other site
221988002207	hypothetical protein; Provisional; Region: PRK05415
221988002208	Domain of unknown function (DUF697); Region: DUF697; cl12064
221988002209	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988002210	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
221988002211	Walker A motif; other site
221988002212	ATP binding site [chemical binding]; other site
221988002213	Walker B motif; other site
221988002214	arginine finger; other site
221988002215	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
221988002216	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988002217	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
221988002218	putative dimerization interface [polypeptide binding]; other site
221988002219	AzlC protein; Region: AzlC; cl00570
221988002220	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
221988002221	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
221988002222	amino acid carrier protein; Region: agcS; TIGR00835
221988002223	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
221988002224	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
221988002225	Domain of unknown function (DUF1919); Region: DUF1919; pfam08942
221988002226	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
221988002227	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
221988002228	active site
221988002229	substrate binding site [chemical binding]; other site
221988002230	metal binding site [ion binding]; metal-binding site
221988002231	GMP synthase; Reviewed; Region: guaA; PRK00074
221988002232	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
221988002233	AMP/PPi binding site [chemical binding]; other site
221988002234	candidate oxyanion hole; other site
221988002235	catalytic triad [active]
221988002236	potential glutamine specificity residues [chemical binding]; other site
221988002237	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
221988002238	ATP Binding subdomain [chemical binding]; other site
221988002239	Ligand Binding sites [chemical binding]; other site
221988002240	Dimerization subdomain; other site
221988002241	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
221988002242	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
221988002243	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
221988002244	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
221988002245	active site
221988002246	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
221988002247	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
221988002248	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
221988002249	Methyltransferase domain; Region: Methyltransf_23; pfam13489
221988002250	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988002251	S-adenosylmethionine binding site [chemical binding]; other site
221988002252	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
221988002253	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
221988002254	Na binding site [ion binding]; other site
221988002255	ribonuclease G; Provisional; Region: PRK11712
221988002256	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
221988002257	homodimer interface [polypeptide binding]; other site
221988002258	oligonucleotide binding site [chemical binding]; other site
221988002259	protease TldD; Provisional; Region: tldD; PRK10735
221988002260	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
221988002261	inhibitor-cofactor binding pocket; inhibition site
221988002262	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988002263	catalytic residue [active]
221988002264	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
221988002265	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
221988002266	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
221988002267	active site turn [active]
221988002268	phosphorylation site [posttranslational modification]
221988002269	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
221988002270	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988002271	Major Facilitator Superfamily; Region: MFS_1; pfam07690
221988002272	putative substrate translocation pore; other site
221988002273	putative protease; Provisional; Region: PRK15452
221988002274	Peptidase family U32; Region: Peptidase_U32; pfam01136
221988002275	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
221988002276	FAD binding site [chemical binding]; other site
221988002277	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
221988002278	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
221988002279	ABC-ATPase subunit  interface; other site
221988002280	dimer interface [polypeptide binding]; other site
221988002281	putative PBP binding regions; other site
221988002282	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
221988002283	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
221988002284	putative peptidase; Provisional; Region: PRK11649
221988002285	Peptidase family M23; Region: Peptidase_M23; pfam01551
221988002286	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
221988002287	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
221988002288	ABC-ATPase subunit  interface; other site
221988002289	dimer interface [polypeptide binding]; other site
221988002290	putative PBP binding regions; other site
221988002291	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
221988002292	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
221988002293	ABC-ATPase subunit  interface; other site
221988002294	dimer interface [polypeptide binding]; other site
221988002295	putative PBP binding regions; other site
221988002296	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
221988002297	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
221988002298	Walker A/P-loop; other site
221988002299	ATP binding site [chemical binding]; other site
221988002300	Q-loop/lid; other site
221988002301	ABC transporter signature motif; other site
221988002302	Walker B; other site
221988002303	D-loop; other site
221988002304	H-loop/switch region; other site
221988002305	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
221988002306	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
221988002307	putative ligand binding residues [chemical binding]; other site
221988002308	adenylate kinase; Reviewed; Region: adk; PRK00279
221988002309	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
221988002310	AMP-binding site [chemical binding]; other site
221988002311	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
221988002312	muropeptide transporter; Reviewed; Region: ampG; PRK11902
221988002313	AmpG-like permease; Region: 2A0125; TIGR00901
221988002314	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
221988002315	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
221988002316	NAD binding site [chemical binding]; other site
221988002317	homodimer interface [polypeptide binding]; other site
221988002318	active site
221988002319	substrate binding site [chemical binding]; other site
221988002320	Protein of unknown function (DUF805); Region: DUF805; pfam05656
221988002321	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
221988002322	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
221988002323	Ligand Binding Site [chemical binding]; other site
221988002324	TilS substrate binding domain; Region: TilS; pfam09179
221988002325	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
221988002326	pyridoxamine kinase; Validated; Region: PRK05756
221988002327	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
221988002328	dimer interface [polypeptide binding]; other site
221988002329	pyridoxal binding site [chemical binding]; other site
221988002330	ATP binding site [chemical binding]; other site
221988002331	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
221988002332	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
221988002333	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
221988002334	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
221988002335	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
221988002336	galactoside permease; Reviewed; Region: lacY; PRK09528
221988002337	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988002338	putative substrate translocation pore; other site
221988002339	Transcriptional regulators [Transcription]; Region: PurR; COG1609
221988002340	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
221988002341	DNA binding site [nucleotide binding]
221988002342	domain linker motif; other site
221988002343	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
221988002344	putative dimerization interface [polypeptide binding]; other site
221988002345	putative ligand binding site [chemical binding]; other site
221988002346	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
221988002347	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
221988002348	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
221988002349	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988002350	dimer interface [polypeptide binding]; other site
221988002351	conserved gate region; other site
221988002352	ABC-ATPase subunit interface; other site
221988002353	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
221988002354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988002355	dimer interface [polypeptide binding]; other site
221988002356	conserved gate region; other site
221988002357	putative PBP binding loops; other site
221988002358	ABC-ATPase subunit interface; other site
221988002359	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
221988002360	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
221988002361	Walker A/P-loop; other site
221988002362	ATP binding site [chemical binding]; other site
221988002363	Q-loop/lid; other site
221988002364	ABC transporter signature motif; other site
221988002365	Walker B; other site
221988002366	D-loop; other site
221988002367	H-loop/switch region; other site
221988002368	TOBE domain; Region: TOBE_2; pfam08402
221988002369	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
221988002370	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
221988002371	metal binding site [ion binding]; metal-binding site
221988002372	dimer interface [polypeptide binding]; other site
221988002373	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
221988002374	mce related protein; Region: MCE; pfam02470
221988002375	mce related protein; Region: MCE; pfam02470
221988002376	mce related protein; Region: MCE; pfam02470
221988002377	mce related protein; Region: MCE; pfam02470
221988002378	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
221988002379	Paraquat-inducible protein A; Region: PqiA; pfam04403
221988002380	Paraquat-inducible protein A; Region: PqiA; pfam04403
221988002381	ProP expression regulator; Provisional; Region: PRK04950
221988002382	ProQ/FINO family; Region: ProQ; smart00945
221988002383	carboxy-terminal protease; Provisional; Region: PRK11186
221988002384	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
221988002385	protein binding site [polypeptide binding]; other site
221988002386	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
221988002387	Catalytic dyad [active]
221988002388	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
221988002389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
221988002390	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
221988002391	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
221988002392	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
221988002393	Peptidase M15; Region: Peptidase_M15_3; cl01194
221988002394	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
221988002395	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
221988002396	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
221988002397	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
221988002398	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988002399	catalytic residue [active]
221988002400	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
221988002401	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
221988002402	inhibitor-cofactor binding pocket; inhibition site
221988002403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988002404	catalytic residue [active]
221988002405	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
221988002406	serine/threonine transporter SstT; Provisional; Region: PRK13628
221988002407	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
221988002408	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
221988002409	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988002410	Walker A/P-loop; other site
221988002411	ATP binding site [chemical binding]; other site
221988002412	Q-loop/lid; other site
221988002413	ABC transporter signature motif; other site
221988002414	Walker B; other site
221988002415	D-loop; other site
221988002416	H-loop/switch region; other site
221988002417	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988002418	Walker A/P-loop; other site
221988002419	ATP binding site [chemical binding]; other site
221988002420	Q-loop/lid; other site
221988002421	ABC transporter signature motif; other site
221988002422	Walker B; other site
221988002423	D-loop; other site
221988002424	H-loop/switch region; other site
221988002425	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
221988002426	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
221988002427	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
221988002428	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
221988002429	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
221988002430	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
221988002431	hypothetical protein; Provisional; Region: PRK11770
221988002432	Domain of unknown function (DUF307); Region: DUF307; pfam03733
221988002433	Domain of unknown function (DUF307); Region: DUF307; pfam03733
221988002434	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
221988002435	active site
221988002436	dimer interfaces [polypeptide binding]; other site
221988002437	catalytic residues [active]
221988002438	ABC transporter ATPase component; Reviewed; Region: PRK11147
221988002439	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
221988002440	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
221988002441	ABC transporter; Region: ABC_tran_2; pfam12848
221988002442	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
221988002443	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
221988002444	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988002445	active site
221988002446	motif I; other site
221988002447	motif II; other site
221988002448	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988002449	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
221988002450	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
221988002451	hypothetical protein; Provisional; Region: PRK01904
221988002452	hypothetical protein; Provisional; Region: PRK03641
221988002453	acylphosphatase; Provisional; Region: PRK14448
221988002454	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
221988002455	DsrC like protein; Region: DsrC; pfam04358
221988002456	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
221988002457	YccA-like proteins; Region: YccA_like; cd10433
221988002458	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
221988002459	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
221988002460	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
221988002461	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
221988002462	Walker A/P-loop; other site
221988002463	ATP binding site [chemical binding]; other site
221988002464	Q-loop/lid; other site
221988002465	ABC transporter signature motif; other site
221988002466	Walker B; other site
221988002467	D-loop; other site
221988002468	H-loop/switch region; other site
221988002469	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
221988002470	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
221988002471	Walker A/P-loop; other site
221988002472	ATP binding site [chemical binding]; other site
221988002473	Q-loop/lid; other site
221988002474	ABC transporter signature motif; other site
221988002475	Walker B; other site
221988002476	D-loop; other site
221988002477	H-loop/switch region; other site
221988002478	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
221988002479	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
221988002480	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
221988002481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988002482	dimer interface [polypeptide binding]; other site
221988002483	conserved gate region; other site
221988002484	putative PBP binding loops; other site
221988002485	ABC-ATPase subunit interface; other site
221988002486	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
221988002487	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988002488	dimer interface [polypeptide binding]; other site
221988002489	conserved gate region; other site
221988002490	putative PBP binding loops; other site
221988002491	ABC-ATPase subunit interface; other site
221988002492	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
221988002493	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
221988002494	peptide binding site [polypeptide binding]; other site
221988002495	YcjX-like family, DUF463; Region: DUF463; pfam04317
221988002496	DNA gyrase subunit A; Validated; Region: PRK05560
221988002497	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
221988002498	CAP-like domain; other site
221988002499	active site
221988002500	primary dimer interface [polypeptide binding]; other site
221988002501	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
221988002502	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
221988002503	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
221988002504	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
221988002505	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
221988002506	ferric uptake regulator; Provisional; Region: fur; PRK09462
221988002507	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
221988002508	metal binding site 2 [ion binding]; metal-binding site
221988002509	putative DNA binding helix; other site
221988002510	metal binding site 1 [ion binding]; metal-binding site
221988002511	dimer interface [polypeptide binding]; other site
221988002512	structural Zn2+ binding site [ion binding]; other site
221988002513	flavodoxin FldA; Validated; Region: PRK09267
221988002514	LexA regulated protein; Provisional; Region: PRK11675
221988002515	acyl-CoA esterase; Provisional; Region: PRK10673
221988002516	PGAP1-like protein; Region: PGAP1; pfam07819
221988002517	replication initiation regulator SeqA; Provisional; Region: PRK11187
221988002518	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
221988002519	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
221988002520	acyl-activating enzyme (AAE) consensus motif; other site
221988002521	putative AMP binding site [chemical binding]; other site
221988002522	putative active site [active]
221988002523	putative CoA binding site [chemical binding]; other site
221988002524	hypothetical protein; Provisional; Region: PRK11281
221988002525	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
221988002526	Mechanosensitive ion channel; Region: MS_channel; pfam00924
221988002527	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
221988002528	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
221988002529	Tetramer interface [polypeptide binding]; other site
221988002530	active site
221988002531	FMN-binding site [chemical binding]; other site
221988002532	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
221988002533	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
221988002534	hypothetical protein; Provisional; Region: PRK10621
221988002535	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
221988002536	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
221988002537	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
221988002538	putative acyl-acceptor binding pocket; other site
221988002539	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
221988002540	active site
221988002541	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
221988002542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988002543	Walker A motif; other site
221988002544	ATP binding site [chemical binding]; other site
221988002545	Walker B motif; other site
221988002546	DNA polymerase III subunit delta'; Validated; Region: PRK08485
221988002547	arginine finger; other site
221988002548	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
221988002549	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
221988002550	hypothetical protein; Provisional; Region: PRK05421
221988002551	putative catalytic site [active]
221988002552	putative metal binding site [ion binding]; other site
221988002553	putative phosphate binding site [ion binding]; other site
221988002554	YwiC-like protein; Region: YwiC; pfam14256
221988002555	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
221988002556	Sel1-like repeats; Region: SEL1; smart00671
221988002557	Sel1 repeat; Region: Sel1; cl02723
221988002558	Sel1-like repeats; Region: SEL1; smart00671
221988002559	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
221988002560	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
221988002561	CAP-like domain; other site
221988002562	active site
221988002563	primary dimer interface [polypeptide binding]; other site
221988002564	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
221988002565	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
221988002566	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
221988002567	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
221988002568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
221988002569	ATP binding site [chemical binding]; other site
221988002570	Mg2+ binding site [ion binding]; other site
221988002571	G-X-G motif; other site
221988002572	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
221988002573	anchoring element; other site
221988002574	dimer interface [polypeptide binding]; other site
221988002575	ATP binding site [chemical binding]; other site
221988002576	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
221988002577	active site
221988002578	putative metal-binding site [ion binding]; other site
221988002579	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
221988002580	bile acid transporter; Region: bass; TIGR00841
221988002581	Sodium Bile acid symporter family; Region: SBF; pfam01758
221988002582	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
221988002583	Serine hydrolase; Region: Ser_hydrolase; cl17834
221988002584	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
221988002585	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
221988002586	dimer interface [polypeptide binding]; other site
221988002587	active site
221988002588	metal binding site [ion binding]; metal-binding site
221988002589	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988002590	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988002591	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
221988002592	dimerization interface [polypeptide binding]; other site
221988002593	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
221988002594	EamA-like transporter family; Region: EamA; pfam00892
221988002595	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
221988002596	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
221988002597	DNA binding residues [nucleotide binding]
221988002598	dimer interface [polypeptide binding]; other site
221988002599	copper binding site [ion binding]; other site
221988002600	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
221988002601	metal-binding site [ion binding]
221988002602	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
221988002603	metal-binding site [ion binding]
221988002604	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
221988002605	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
221988002606	metal-binding site [ion binding]
221988002607	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
221988002608	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988002609	motif II; other site
221988002610	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
221988002611	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
221988002612	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
221988002613	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
221988002614	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
221988002615	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
221988002616	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
221988002617	molybdopterin cofactor binding site; other site
221988002618	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
221988002619	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
221988002620	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
221988002621	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
221988002622	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
221988002623	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988002624	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
221988002625	dimerization interface [polypeptide binding]; other site
221988002626	substrate binding pocket [chemical binding]; other site
221988002627	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
221988002628	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
221988002629	homodimer interface [polypeptide binding]; other site
221988002630	substrate-cofactor binding pocket; other site
221988002631	catalytic residue [active]
221988002632	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
221988002633	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
221988002634	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
221988002635	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
221988002636	nucleotide binding site [chemical binding]; other site
221988002637	chaperone protein DnaJ; Provisional; Region: PRK10767
221988002638	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
221988002639	HSP70 interaction site [polypeptide binding]; other site
221988002640	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
221988002641	substrate binding site [polypeptide binding]; other site
221988002642	dimer interface [polypeptide binding]; other site
221988002643	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
221988002644	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
221988002645	substrate binding pocket [chemical binding]; other site
221988002646	membrane-bound complex binding site; other site
221988002647	hinge residues; other site
221988002648	Transglycosylase SLT domain; Region: SLT_2; pfam13406
221988002649	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
221988002650	N-acetyl-D-glucosamine binding site [chemical binding]; other site
221988002651	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
221988002652	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
221988002653	active site
221988002654	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
221988002655	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
221988002656	active site
221988002657	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
221988002658	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
221988002659	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
221988002660	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
221988002661	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
221988002662	Uncharacterized conserved protein [Function unknown]; Region: COG1434
221988002663	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
221988002664	putative active site [active]
221988002665	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
221988002666	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
221988002667	substrate binding [chemical binding]; other site
221988002668	active site
221988002669	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
221988002670	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
221988002671	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
221988002672	inhibitor-cofactor binding pocket; inhibition site
221988002673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988002674	catalytic residue [active]
221988002675	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
221988002676	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
221988002677	Mg++ binding site [ion binding]; other site
221988002678	putative catalytic motif [active]
221988002679	substrate binding site [chemical binding]; other site
221988002680	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
221988002681	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
221988002682	Na2 binding site [ion binding]; other site
221988002683	putative substrate binding site 1 [chemical binding]; other site
221988002684	Na binding site 1 [ion binding]; other site
221988002685	putative substrate binding site 2 [chemical binding]; other site
221988002686	endonuclease III; Provisional; Region: PRK10702
221988002687	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
221988002688	minor groove reading motif; other site
221988002689	helix-hairpin-helix signature motif; other site
221988002690	substrate binding pocket [chemical binding]; other site
221988002691	active site
221988002692	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
221988002693	electron transport complex RsxE subunit; Provisional; Region: PRK12405
221988002694	electron transport complex protein RnfG; Validated; Region: PRK01908
221988002695	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
221988002696	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
221988002697	SLBB domain; Region: SLBB; pfam10531
221988002698	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
221988002699	ferredoxin; Provisional; Region: PRK08764
221988002700	Putative Fe-S cluster; Region: FeS; cl17515
221988002701	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
221988002702	electron transport complex protein RsxA; Provisional; Region: PRK05151
221988002703	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
221988002704	putative active site [active]
221988002705	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
221988002706	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
221988002707	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
221988002708	catalytic center binding site [active]
221988002709	ATP binding site [chemical binding]; other site
221988002710	poly(A) polymerase; Region: pcnB; TIGR01942
221988002711	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
221988002712	active site
221988002713	NTP binding site [chemical binding]; other site
221988002714	metal binding triad [ion binding]; metal-binding site
221988002715	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
221988002716	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
221988002717	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
221988002718	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
221988002719	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
221988002720	Competence protein; Region: Competence; pfam03772
221988002721	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
221988002722	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
221988002723	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
221988002724	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
221988002725	Walker A/P-loop; other site
221988002726	ATP binding site [chemical binding]; other site
221988002727	Q-loop/lid; other site
221988002728	ABC transporter signature motif; other site
221988002729	Walker B; other site
221988002730	D-loop; other site
221988002731	H-loop/switch region; other site
221988002732	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
221988002733	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
221988002734	Uncharacterized conserved protein [Function unknown]; Region: COG2835
221988002735	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
221988002736	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
221988002737	Ligand binding site; other site
221988002738	oligomer interface; other site
221988002739	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
221988002740	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
221988002741	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
221988002742	GIY-YIG motif/motif A; other site
221988002743	active site
221988002744	catalytic site [active]
221988002745	putative DNA binding site [nucleotide binding]; other site
221988002746	metal binding site [ion binding]; metal-binding site
221988002747	UvrB/uvrC motif; Region: UVR; pfam02151
221988002748	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
221988002749	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
221988002750	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
221988002751	DNA binding site [nucleotide binding]
221988002752	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636
221988002753	active site
221988002754	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
221988002755	DNA binding site [nucleotide binding]
221988002756	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
221988002757	substrate binding site [chemical binding]; other site
221988002758	THF binding site; other site
221988002759	zinc-binding site [ion binding]; other site
221988002760	Protein of unknown function (DUF808); Region: DUF808; pfam05661
221988002761	uncharacterized domain; Region: TIGR00702
221988002762	YcaO-like family; Region: YcaO; pfam02624
221988002763	Methyltransferase domain; Region: Methyltransf_11; pfam08241
221988002764	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
221988002765	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
221988002766	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
221988002767	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
221988002768	active site
221988002769	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
221988002770	catalytic triad [active]
221988002771	dimer interface [polypeptide binding]; other site
221988002772	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
221988002773	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
221988002774	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
221988002775	Walker A/P-loop; other site
221988002776	ATP binding site [chemical binding]; other site
221988002777	Q-loop/lid; other site
221988002778	ABC transporter signature motif; other site
221988002779	Walker B; other site
221988002780	D-loop; other site
221988002781	H-loop/switch region; other site
221988002782	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
221988002783	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
221988002784	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988002785	Walker A/P-loop; other site
221988002786	ATP binding site [chemical binding]; other site
221988002787	Q-loop/lid; other site
221988002788	ABC transporter signature motif; other site
221988002789	Walker B; other site
221988002790	D-loop; other site
221988002791	H-loop/switch region; other site
221988002792	thioredoxin reductase; Provisional; Region: PRK10262
221988002793	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
221988002794	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
221988002795	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
221988002796	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
221988002797	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
221988002798	fructuronate transporter; Provisional; Region: PRK10034; cl15264
221988002799	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
221988002800	fructuronate transporter; Provisional; Region: PRK10034; cl15264
221988002801	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
221988002802	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
221988002803	NADP binding site [chemical binding]; other site
221988002804	homodimer interface [polypeptide binding]; other site
221988002805	active site
221988002806	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
221988002807	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
221988002808	putative NAD(P) binding site [chemical binding]; other site
221988002809	catalytic Zn binding site [ion binding]; other site
221988002810	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
221988002811	Shikimate kinase; Region: SKI; pfam01202
221988002812	ATP-binding site [chemical binding]; other site
221988002813	Gluconate-6-phosphate binding site [chemical binding]; other site
221988002814	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
221988002815	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
221988002816	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
221988002817	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
221988002818	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
221988002819	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
221988002820	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
221988002821	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
221988002822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988002823	S-adenosylmethionine binding site [chemical binding]; other site
221988002824	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
221988002825	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988002826	Walker A motif; other site
221988002827	ATP binding site [chemical binding]; other site
221988002828	Walker B motif; other site
221988002829	arginine finger; other site
221988002830	Peptidase family M41; Region: Peptidase_M41; pfam01434
221988002831	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
221988002832	dihydropteroate synthase; Region: DHPS; TIGR01496
221988002833	substrate binding pocket [chemical binding]; other site
221988002834	dimer interface [polypeptide binding]; other site
221988002835	inhibitor binding site; inhibition site
221988002836	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
221988002837	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
221988002838	active site
221988002839	substrate binding site [chemical binding]; other site
221988002840	metal binding site [ion binding]; metal-binding site
221988002841	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
221988002842	dimer interface [polypeptide binding]; other site
221988002843	putative radical transfer pathway; other site
221988002844	diiron center [ion binding]; other site
221988002845	tyrosyl radical; other site
221988002846	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
221988002847	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
221988002848	catalytic loop [active]
221988002849	iron binding site [ion binding]; other site
221988002850	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
221988002851	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
221988002852	transmembrane helices; other site
221988002853	dihydrodipicolinate reductase; Provisional; Region: PRK00048
221988002854	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
221988002855	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
221988002856	LysE type translocator; Region: LysE; cl00565
221988002857	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
221988002858	tetramer interfaces [polypeptide binding]; other site
221988002859	binuclear metal-binding site [ion binding]; other site
221988002860	thiamine monophosphate kinase; Provisional; Region: PRK05731
221988002861	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
221988002862	ATP binding site [chemical binding]; other site
221988002863	dimerization interface [polypeptide binding]; other site
221988002864	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
221988002865	putative RNA binding site [nucleotide binding]; other site
221988002866	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
221988002867	homopentamer interface [polypeptide binding]; other site
221988002868	active site
221988002869	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
221988002870	aromatic amino acid transport protein; Region: araaP; TIGR00837
221988002871	putative transposase OrfB; Reviewed; Region: PHA02517
221988002872	HTH-like domain; Region: HTH_21; pfam13276
221988002873	Integrase core domain; Region: rve; pfam00665
221988002874	Integrase core domain; Region: rve_3; pfam13683
221988002875	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
221988002876	Transposase; Region: HTH_Tnp_1; pfam01527
221988002877	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
221988002878	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
221988002879	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
221988002880	Uncharacterized conserved protein [Function unknown]; Region: COG1432
221988002881	putative metal binding site [ion binding]; other site
221988002882	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
221988002883	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
221988002884	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
221988002885	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
221988002886	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
221988002887	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
221988002888	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
221988002889	Peptidase A6 family; Region: Peptidase_A6; pfam01829
221988002890	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
221988002891	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
221988002892	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
221988002893	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
221988002894	ATP cone domain; Region: ATP-cone; pfam03477
221988002895	Class I ribonucleotide reductase; Region: RNR_I; cd01679
221988002896	active site
221988002897	dimer interface [polypeptide binding]; other site
221988002898	catalytic residues [active]
221988002899	effector binding site; other site
221988002900	R2 peptide binding site; other site
221988002901	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
221988002902	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
221988002903	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
221988002904	protein binding site [polypeptide binding]; other site
221988002905	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
221988002906	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
221988002907	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988002908	active site
221988002909	motif I; other site
221988002910	motif II; other site
221988002911	KpsF/GutQ family protein; Region: kpsF; TIGR00393
221988002912	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
221988002913	putative active site [active]
221988002914	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
221988002915	phosphate acetyltransferase; Reviewed; Region: PRK05632
221988002916	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
221988002917	DRTGG domain; Region: DRTGG; pfam07085
221988002918	phosphate acetyltransferase; Region: pta; TIGR00651
221988002919	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
221988002920	propionate/acetate kinase; Provisional; Region: PRK12379
221988002921	hypothetical protein; Provisional; Region: PRK01816
221988002922	Colicin V production protein; Region: Colicin_V; cl00567
221988002923	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
221988002924	amidophosphoribosyltransferase; Provisional; Region: PRK09246
221988002925	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
221988002926	active site
221988002927	tetramer interface [polypeptide binding]; other site
221988002928	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
221988002929	active site
221988002930	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
221988002931	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
221988002932	ATP binding site [chemical binding]; other site
221988002933	substrate interface [chemical binding]; other site
221988002934	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
221988002935	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
221988002936	dimer interface [polypeptide binding]; other site
221988002937	putative functional site; other site
221988002938	putative MPT binding site; other site
221988002939	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
221988002940	AAA domain; Region: AAA_26; pfam13500
221988002941	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
221988002942	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
221988002943	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
221988002944	substrate binding pocket [chemical binding]; other site
221988002945	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
221988002946	B12 binding site [chemical binding]; other site
221988002947	cobalt ligand [ion binding]; other site
221988002948	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
221988002949	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
221988002950	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
221988002951	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
221988002952	Walker A/P-loop; other site
221988002953	ATP binding site [chemical binding]; other site
221988002954	Q-loop/lid; other site
221988002955	ABC transporter signature motif; other site
221988002956	Walker B; other site
221988002957	D-loop; other site
221988002958	H-loop/switch region; other site
221988002959	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
221988002960	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
221988002961	ABC-ATPase subunit  interface; other site
221988002962	dimer interface [polypeptide binding]; other site
221988002963	putative PBP binding regions; other site
221988002964	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
221988002965	intersubunit interface [polypeptide binding]; other site
221988002966	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
221988002967	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
221988002968	N-terminal plug; other site
221988002969	ligand-binding site [chemical binding]; other site
221988002970	dsDNA-mimic protein; Reviewed; Region: PRK05094
221988002971	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
221988002972	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
221988002973	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
221988002974	DsrE/DsrF-like family; Region: DrsE; cl00672
221988002975	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
221988002976	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
221988002977	phosphate binding site [ion binding]; other site
221988002978	putative substrate binding pocket [chemical binding]; other site
221988002979	dimer interface [polypeptide binding]; other site
221988002980	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
221988002981	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988002982	FeS/SAM binding site; other site
221988002983	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
221988002984	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
221988002985	trimer interface [polypeptide binding]; other site
221988002986	dimer interface [polypeptide binding]; other site
221988002987	putative active site [active]
221988002988	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
221988002989	MoaE interaction surface [polypeptide binding]; other site
221988002990	MoeB interaction surface [polypeptide binding]; other site
221988002991	thiocarboxylated glycine; other site
221988002992	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
221988002993	MoaE homodimer interface [polypeptide binding]; other site
221988002994	MoaD interaction [polypeptide binding]; other site
221988002995	active site residues [active]
221988002996	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
221988002997	DNA methylase; Region: N6_N4_Mtase; pfam01555
221988002998	DNA methylase; Region: N6_N4_Mtase; pfam01555
221988002999	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
221988003000	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
221988003001	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
221988003002	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
221988003003	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
221988003004	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
221988003005	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
221988003006	[4Fe-4S] binding site [ion binding]; other site
221988003007	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
221988003008	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
221988003009	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
221988003010	molybdopterin cofactor binding site; other site
221988003011	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
221988003012	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
221988003013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988003014	homodimer interface [polypeptide binding]; other site
221988003015	catalytic residue [active]
221988003016	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
221988003017	ATP-grasp domain; Region: ATP-grasp; pfam02222
221988003018	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
221988003019	aminopeptidase N; Provisional; Region: pepN; PRK14015
221988003020	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
221988003021	active site
221988003022	Zn binding site [ion binding]; other site
221988003023	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
221988003024	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
221988003025	quinone interaction residues [chemical binding]; other site
221988003026	active site
221988003027	catalytic residues [active]
221988003028	FMN binding site [chemical binding]; other site
221988003029	substrate binding site [chemical binding]; other site
221988003030	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
221988003031	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
221988003032	active site
221988003033	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
221988003034	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
221988003035	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
221988003036	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
221988003037	RNA binding surface [nucleotide binding]; other site
221988003038	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
221988003039	probable active site [active]
221988003040	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
221988003041	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988003042	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
221988003043	substrate binding site [chemical binding]; other site
221988003044	dimerization interface [polypeptide binding]; other site
221988003045	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
221988003046	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
221988003047	putative dimer interface [polypeptide binding]; other site
221988003048	putative anticodon binding site; other site
221988003049	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
221988003050	homodimer interface [polypeptide binding]; other site
221988003051	motif 1; other site
221988003052	motif 2; other site
221988003053	active site
221988003054	motif 3; other site
221988003055	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
221988003056	homodecamer interface [polypeptide binding]; other site
221988003057	GTP cyclohydrolase I; Provisional; Region: PLN03044
221988003058	active site
221988003059	putative catalytic site residues [active]
221988003060	zinc binding site [ion binding]; other site
221988003061	GTP-CH-I/GFRP interaction surface; other site
221988003062	hypothetical protein; Provisional; Region: PRK06762
221988003063	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
221988003064	YcgL domain; Region: YcgL; pfam05166
221988003065	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
221988003066	putative catalytic site [active]
221988003067	putative phosphate binding site [ion binding]; other site
221988003068	active site
221988003069	metal binding site A [ion binding]; metal-binding site
221988003070	DNA binding site [nucleotide binding]
221988003071	putative AP binding site [nucleotide binding]; other site
221988003072	putative metal binding site B [ion binding]; other site
221988003073	Family of unknown function (DUF695); Region: DUF695; pfam05117
221988003074	TIGR01619 family protein; Region: hyp_HI0040
221988003075	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
221988003076	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988003077	motif II; other site
221988003078	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
221988003079	Phosphotransferase enzyme family; Region: APH; pfam01636
221988003080	active site
221988003081	ATP binding site [chemical binding]; other site
221988003082	glutaredoxin 2; Provisional; Region: PRK10387
221988003083	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
221988003084	C-terminal domain interface [polypeptide binding]; other site
221988003085	GSH binding site (G-site) [chemical binding]; other site
221988003086	catalytic residues [active]
221988003087	putative dimer interface [polypeptide binding]; other site
221988003088	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
221988003089	N-terminal domain interface [polypeptide binding]; other site
221988003090	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
221988003091	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
221988003092	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
221988003093	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
221988003094	active site
221988003095	dimer interface [polypeptide binding]; other site
221988003096	motif 1; other site
221988003097	motif 2; other site
221988003098	motif 3; other site
221988003099	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
221988003100	anticodon binding site; other site
221988003101	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
221988003102	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
221988003103	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
221988003104	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
221988003105	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
221988003106	23S rRNA binding site [nucleotide binding]; other site
221988003107	L21 binding site [polypeptide binding]; other site
221988003108	L13 binding site [polypeptide binding]; other site
221988003109	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
221988003110	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
221988003111	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
221988003112	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
221988003113	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
221988003114	TPP-binding site; other site
221988003115	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
221988003116	PYR/PP interface [polypeptide binding]; other site
221988003117	dimer interface [polypeptide binding]; other site
221988003118	TPP binding site [chemical binding]; other site
221988003119	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
221988003120	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
221988003121	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
221988003122	substrate binding pocket [chemical binding]; other site
221988003123	chain length determination region; other site
221988003124	substrate-Mg2+ binding site; other site
221988003125	catalytic residues [active]
221988003126	aspartate-rich region 1; other site
221988003127	active site lid residues [active]
221988003128	aspartate-rich region 2; other site
221988003129	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
221988003130	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
221988003131	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
221988003132	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
221988003133	Ligand Binding Site [chemical binding]; other site
221988003134	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
221988003135	active site residue [active]
221988003136	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
221988003137	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
221988003138	DNA binding site [nucleotide binding]
221988003139	domain linker motif; other site
221988003140	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
221988003141	dimerization interface [polypeptide binding]; other site
221988003142	ligand binding site [chemical binding]; other site
221988003143	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
221988003144	active site clefts [active]
221988003145	zinc binding site [ion binding]; other site
221988003146	dimer interface [polypeptide binding]; other site
221988003147	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
221988003148	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
221988003149	Walker A/P-loop; other site
221988003150	ATP binding site [chemical binding]; other site
221988003151	Q-loop/lid; other site
221988003152	ABC transporter signature motif; other site
221988003153	Walker B; other site
221988003154	D-loop; other site
221988003155	H-loop/switch region; other site
221988003156	inner membrane transport permease; Provisional; Region: PRK15066
221988003157	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
221988003158	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
221988003159	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
221988003160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
221988003161	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
221988003162	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
221988003163	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071
221988003164	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
221988003165	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
221988003166	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
221988003167	probable active site [active]
221988003168	ornithine carbamoyltransferase; Provisional; Region: PRK01713
221988003169	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
221988003170	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
221988003171	hypothetical protein; Provisional; Region: PRK05114
221988003172	universal stress protein UspE; Provisional; Region: PRK11175
221988003173	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
221988003174	Ligand Binding Site [chemical binding]; other site
221988003175	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
221988003176	Ligand Binding Site [chemical binding]; other site
221988003177	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
221988003178	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
221988003179	ligand binding site [chemical binding]; other site
221988003180	flexible hinge region; other site
221988003181	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
221988003182	putative switch regulator; other site
221988003183	non-specific DNA interactions [nucleotide binding]; other site
221988003184	DNA binding site [nucleotide binding]
221988003185	sequence specific DNA binding site [nucleotide binding]; other site
221988003186	putative cAMP binding site [chemical binding]; other site
221988003187	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
221988003188	Ferritin-like domain; Region: Ferritin; pfam00210
221988003189	ferroxidase diiron center [ion binding]; other site
221988003190	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
221988003191	Ferritin-like domain; Region: Ferritin; pfam00210
221988003192	ferroxidase diiron center [ion binding]; other site
221988003193	exonuclease I; Provisional; Region: sbcB; PRK11779
221988003194	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
221988003195	active site
221988003196	catalytic site [active]
221988003197	substrate binding site [chemical binding]; other site
221988003198	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
221988003199	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
221988003200	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
221988003201	P-loop containing region of AAA domain; Region: AAA_29; cl17516
221988003202	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
221988003203	condesin subunit E; Provisional; Region: PRK05256
221988003204	condesin subunit F; Provisional; Region: PRK05260
221988003205	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
221988003206	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
221988003207	Ligand Binding Site [chemical binding]; other site
221988003208	NlpC/P60 family; Region: NLPC_P60; pfam00877
221988003209	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
221988003210	IHF dimer interface [polypeptide binding]; other site
221988003211	IHF - DNA interface [nucleotide binding]; other site
221988003212	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
221988003213	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
221988003214	putative tRNA-binding site [nucleotide binding]; other site
221988003215	B3/4 domain; Region: B3_4; pfam03483
221988003216	tRNA synthetase B5 domain; Region: B5; smart00874
221988003217	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
221988003218	dimer interface [polypeptide binding]; other site
221988003219	motif 1; other site
221988003220	motif 3; other site
221988003221	motif 2; other site
221988003222	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
221988003223	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
221988003224	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
221988003225	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
221988003226	dimer interface [polypeptide binding]; other site
221988003227	motif 1; other site
221988003228	active site
221988003229	motif 2; other site
221988003230	motif 3; other site
221988003231	Uncharacterized conserved protein [Function unknown]; Region: COG3422
221988003232	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
221988003233	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
221988003234	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
221988003235	sequence-specific DNA binding site [nucleotide binding]; other site
221988003236	salt bridge; other site
221988003237	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
221988003238	DNA-binding site [nucleotide binding]; DNA binding site
221988003239	RNA-binding motif; other site
221988003240	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
221988003241	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
221988003242	active site
221988003243	interdomain interaction site; other site
221988003244	putative metal-binding site [ion binding]; other site
221988003245	nucleotide binding site [chemical binding]; other site
221988003246	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
221988003247	domain I; other site
221988003248	DNA binding groove [nucleotide binding]
221988003249	phosphate binding site [ion binding]; other site
221988003250	domain II; other site
221988003251	domain III; other site
221988003252	nucleotide binding site [chemical binding]; other site
221988003253	catalytic site [active]
221988003254	domain IV; other site
221988003255	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
221988003256	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
221988003257	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
221988003258	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
221988003259	LysR family transcriptional regulator; Provisional; Region: PRK14997
221988003260	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988003261	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
221988003262	putative effector binding pocket; other site
221988003263	dimerization interface [polypeptide binding]; other site
221988003264	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
221988003265	AAA domain; Region: AAA_30; pfam13604
221988003266	Family description; Region: UvrD_C_2; pfam13538
221988003267	Part of AAA domain; Region: AAA_19; pfam13245
221988003268	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
221988003269	Family description; Region: UvrD_C_2; pfam13538
221988003270	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
221988003271	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
221988003272	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
221988003273	prephenate dehydrogenase; Validated; Region: PRK08507
221988003274	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
221988003275	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
221988003276	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
221988003277	tartrate dehydrogenase; Region: TTC; TIGR02089
221988003278	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
221988003279	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
221988003280	tandem repeat interface [polypeptide binding]; other site
221988003281	oligomer interface [polypeptide binding]; other site
221988003282	active site residues [active]
221988003283	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
221988003284	tandem repeat interface [polypeptide binding]; other site
221988003285	oligomer interface [polypeptide binding]; other site
221988003286	active site residues [active]
221988003287	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
221988003288	putative FMN binding site [chemical binding]; other site
221988003289	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
221988003290	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
221988003291	active site
221988003292	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
221988003293	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
221988003294	DXD motif; other site
221988003295	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
221988003296	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
221988003297	putative active site [active]
221988003298	putative metal binding site [ion binding]; other site
221988003299	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
221988003300	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
221988003301	5S rRNA interface [nucleotide binding]; other site
221988003302	CTC domain interface [polypeptide binding]; other site
221988003303	L16 interface [polypeptide binding]; other site
221988003304	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
221988003305	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
221988003306	glycogen phosphorylase; Provisional; Region: PRK14986
221988003307	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
221988003308	homodimer interface [polypeptide binding]; other site
221988003309	active site pocket [active]
221988003310	glycogen synthase; Provisional; Region: glgA; PRK00654
221988003311	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
221988003312	ADP-binding pocket [chemical binding]; other site
221988003313	homodimer interface [polypeptide binding]; other site
221988003314	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
221988003315	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
221988003316	ligand binding site; other site
221988003317	oligomer interface; other site
221988003318	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
221988003319	dimer interface [polypeptide binding]; other site
221988003320	N-terminal domain interface [polypeptide binding]; other site
221988003321	sulfate 1 binding site; other site
221988003322	glycogen debranching enzyme; Provisional; Region: PRK03705
221988003323	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
221988003324	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
221988003325	active site
221988003326	catalytic site [active]
221988003327	glycogen branching enzyme; Provisional; Region: PRK05402
221988003328	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
221988003329	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
221988003330	active site
221988003331	catalytic site [active]
221988003332	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
221988003333	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
221988003334	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
221988003335	hypothetical protein; Provisional; Region: PRK05170
221988003336	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
221988003337	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
221988003338	active site
221988003339	HIGH motif; other site
221988003340	nucleotide binding site [chemical binding]; other site
221988003341	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
221988003342	KMSKS motif; other site
221988003343	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
221988003344	macrolide transporter subunit MacA; Provisional; Region: PRK11578
221988003345	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
221988003346	HlyD family secretion protein; Region: HlyD_3; pfam13437
221988003347	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
221988003348	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
221988003349	Walker A/P-loop; other site
221988003350	ATP binding site [chemical binding]; other site
221988003351	Q-loop/lid; other site
221988003352	ABC transporter signature motif; other site
221988003353	Walker B; other site
221988003354	D-loop; other site
221988003355	H-loop/switch region; other site
221988003356	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
221988003357	FtsX-like permease family; Region: FtsX; pfam02687
221988003358	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
221988003359	Protein of unknown function, DUF462; Region: DUF462; cl01190
221988003360	Protein of unknown function, DUF462; Region: DUF462; cl01190
221988003361	heat shock protein HtpX; Provisional; Region: PRK05457
221988003362	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
221988003363	active site
221988003364	DNA polymerase IV; Validated; Region: PRK02406
221988003365	DNA binding site [nucleotide binding]
221988003366	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
221988003367	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
221988003368	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
221988003369	putative active site [active]
221988003370	putative metal-binding site [ion binding]; other site
221988003371	Predicted membrane protein [Function unknown]; Region: COG2431
221988003372	Rhodanese-like domain; Region: Rhodanese; pfam00581
221988003373	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
221988003374	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
221988003375	active site residue [active]
221988003376	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
221988003377	active site residue [active]
221988003378	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
221988003379	active site residue [active]
221988003380	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
221988003381	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
221988003382	active site residue [active]
221988003383	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
221988003384	active site residue [active]
221988003385	Predicted transporter component [General function prediction only]; Region: COG2391
221988003386	Sulphur transport; Region: Sulf_transp; pfam04143
221988003387	Sulphur transport; Region: Sulf_transp; pfam04143
221988003388	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
221988003389	DNA-binding site [nucleotide binding]; DNA binding site
221988003390	RNA-binding motif; other site
221988003391	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
221988003392	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
221988003393	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
221988003394	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
221988003395	ligand binding site [chemical binding]; other site
221988003396	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
221988003397	putative inner membrane peptidase; Provisional; Region: PRK11778
221988003398	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
221988003399	tandem repeat interface [polypeptide binding]; other site
221988003400	oligomer interface [polypeptide binding]; other site
221988003401	active site residues [active]
221988003402	anthranilate synthase component I; Provisional; Region: PRK13564
221988003403	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
221988003404	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
221988003405	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
221988003406	Glutamine amidotransferase class-I; Region: GATase; pfam00117
221988003407	glutamine binding [chemical binding]; other site
221988003408	catalytic triad [active]
221988003409	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
221988003410	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
221988003411	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
221988003412	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
221988003413	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
221988003414	active site
221988003415	ribulose/triose binding site [chemical binding]; other site
221988003416	phosphate binding site [ion binding]; other site
221988003417	substrate (anthranilate) binding pocket [chemical binding]; other site
221988003418	product (indole) binding pocket [chemical binding]; other site
221988003419	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
221988003420	active site
221988003421	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
221988003422	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
221988003423	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988003424	catalytic residue [active]
221988003425	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
221988003426	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
221988003427	substrate binding site [chemical binding]; other site
221988003428	active site
221988003429	catalytic residues [active]
221988003430	heterodimer interface [polypeptide binding]; other site
221988003431	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
221988003432	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
221988003433	G1 box; other site
221988003434	GTP/Mg2+ binding site [chemical binding]; other site
221988003435	Switch I region; other site
221988003436	G2 box; other site
221988003437	G3 box; other site
221988003438	Switch II region; other site
221988003439	G4 box; other site
221988003440	G5 box; other site
221988003441	Nucleoside recognition; Region: Gate; pfam07670
221988003442	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
221988003443	Nucleoside recognition; Region: Gate; pfam07670
221988003444	FeoA domain; Region: FeoA; pfam04023
221988003445	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
221988003446	Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829
221988003447	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
221988003448	haemagglutination activity domain; Region: Haemagg_act; pfam05860
221988003449	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
221988003450	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
221988003451	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
221988003452	Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829
221988003453	RTX toxin acyltransferase family; Region: HlyC; pfam02794
221988003454	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
221988003455	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
221988003456	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
221988003457	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
221988003458	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
221988003459	active site
221988003460	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
221988003461	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
221988003462	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
221988003463	putative active site [active]
221988003464	catalytic site [active]
221988003465	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
221988003466	putative active site [active]
221988003467	catalytic site [active]
221988003468	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
221988003469	catalytic core [active]
221988003470	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
221988003471	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
221988003472	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
221988003473	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
221988003474	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
221988003475	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
221988003476	dimerization interface 3.5A [polypeptide binding]; other site
221988003477	active site
221988003478	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
221988003479	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
221988003480	trimer interface [polypeptide binding]; other site
221988003481	active site
221988003482	substrate binding site [chemical binding]; other site
221988003483	CoA binding site [chemical binding]; other site
221988003484	sugar efflux transporter B; Provisional; Region: PRK15011
221988003485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988003486	putative substrate translocation pore; other site
221988003487	hypothetical protein; Provisional; Region: PRK11111
221988003488	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
221988003489	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
221988003490	active site
221988003491	dimer interface [polypeptide binding]; other site
221988003492	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
221988003493	dimer interface [polypeptide binding]; other site
221988003494	active site
221988003495	alanine racemase; Reviewed; Region: alr; PRK00053
221988003496	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
221988003497	active site
221988003498	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
221988003499	substrate binding site [chemical binding]; other site
221988003500	catalytic residues [active]
221988003501	dimer interface [polypeptide binding]; other site
221988003502	replicative DNA helicase; Validated; Region: PRK06904
221988003503	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
221988003504	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
221988003505	Walker A motif; other site
221988003506	ATP binding site [chemical binding]; other site
221988003507	Walker B motif; other site
221988003508	DNA binding loops [nucleotide binding]
221988003509	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
221988003510	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
221988003511	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
221988003512	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
221988003513	FtsX-like permease family; Region: FtsX; pfam02687
221988003514	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
221988003515	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
221988003516	Walker A/P-loop; other site
221988003517	ATP binding site [chemical binding]; other site
221988003518	Q-loop/lid; other site
221988003519	ABC transporter signature motif; other site
221988003520	Walker B; other site
221988003521	D-loop; other site
221988003522	H-loop/switch region; other site
221988003523	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
221988003524	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
221988003525	FtsX-like permease family; Region: FtsX; pfam02687
221988003526	glycerate dehydrogenase; Provisional; Region: PRK06932
221988003527	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
221988003528	putative ligand binding site [chemical binding]; other site
221988003529	putative NAD binding site [chemical binding]; other site
221988003530	catalytic site [active]
221988003531	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
221988003532	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
221988003533	Uncharacterized conserved protein [Function unknown]; Region: COG2912
221988003534	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
221988003535	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
221988003536	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988003537	peptide chain release factor 1; Validated; Region: prfA; PRK00591
221988003538	This domain is found in peptide chain release factors; Region: PCRF; smart00937
221988003539	RF-1 domain; Region: RF-1; pfam00472
221988003540	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
221988003541	active site 1 [active]
221988003542	dimer interface [polypeptide binding]; other site
221988003543	active site 2 [active]
221988003544	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
221988003545	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
221988003546	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
221988003547	pyruvate kinase; Provisional; Region: PRK05826
221988003548	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
221988003549	domain interfaces; other site
221988003550	active site
221988003551	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
221988003552	catalytic core [active]
221988003553	oligopeptidase A; Provisional; Region: PRK10911
221988003554	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
221988003555	active site
221988003556	Zn binding site [ion binding]; other site
221988003557	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
221988003558	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
221988003559	Walker A/P-loop; other site
221988003560	ATP binding site [chemical binding]; other site
221988003561	Q-loop/lid; other site
221988003562	ABC transporter signature motif; other site
221988003563	Walker B; other site
221988003564	D-loop; other site
221988003565	H-loop/switch region; other site
221988003566	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
221988003567	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
221988003568	siderophore binding site; other site
221988003569	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
221988003570	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
221988003571	ABC-ATPase subunit  interface; other site
221988003572	dimer interface [polypeptide binding]; other site
221988003573	putative PBP binding regions; other site
221988003574	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
221988003575	ABC-ATPase subunit  interface; other site
221988003576	dimer interface [polypeptide binding]; other site
221988003577	putative PBP binding regions; other site
221988003578	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
221988003579	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
221988003580	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
221988003581	Walker A/P-loop; other site
221988003582	ATP binding site [chemical binding]; other site
221988003583	Q-loop/lid; other site
221988003584	ABC transporter signature motif; other site
221988003585	Walker B; other site
221988003586	D-loop; other site
221988003587	H-loop/switch region; other site
221988003588	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
221988003589	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
221988003590	N-terminal plug; other site
221988003591	ligand-binding site [chemical binding]; other site
221988003592	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
221988003593	flavodoxin; Provisional; Region: PRK06934
221988003594	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
221988003595	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
221988003596	active site
221988003597	catalytic tetrad [active]
221988003598	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988003599	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988003600	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
221988003601	putative effector binding pocket; other site
221988003602	putative dimerization interface [polypeptide binding]; other site
221988003603	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
221988003604	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
221988003605	putative substrate binding site [chemical binding]; other site
221988003606	putative ATP binding site [chemical binding]; other site
221988003607	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
221988003608	putative GSH binding site [chemical binding]; other site
221988003609	catalytic residues [active]
221988003610	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
221988003611	Repair protein; Region: Repair_PSII; pfam04536
221988003612	Repair protein; Region: Repair_PSII; cl01535
221988003613	LemA family; Region: LemA; pfam04011
221988003614	outer membrane protein A; Reviewed; Region: PRK10808
221988003615	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
221988003616	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
221988003617	ligand binding site [chemical binding]; other site
221988003618	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
221988003619	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
221988003620	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
221988003621	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
221988003622	FAD binding domain; Region: FAD_binding_4; pfam01565
221988003623	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
221988003624	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
221988003625	putative active site [active]
221988003626	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
221988003627	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
221988003628	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
221988003629	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
221988003630	ligand binding site [chemical binding]; other site
221988003631	homodimer interface [polypeptide binding]; other site
221988003632	NAD(P) binding site [chemical binding]; other site
221988003633	trimer interface B [polypeptide binding]; other site
221988003634	trimer interface A [polypeptide binding]; other site
221988003635	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
221988003636	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
221988003637	Melibiase; Region: Melibiase; pfam02065
221988003638	melibiose:sodium symporter; Provisional; Region: PRK10429
221988003639	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
221988003640	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
221988003641	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988003642	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
221988003643	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
221988003644	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
221988003645	active site
221988003646	HIGH motif; other site
221988003647	dimer interface [polypeptide binding]; other site
221988003648	KMSKS motif; other site
221988003649	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
221988003650	RNA binding surface [nucleotide binding]; other site
221988003651	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
221988003652	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
221988003653	putative substrate binding site [chemical binding]; other site
221988003654	putative ATP binding site [chemical binding]; other site
221988003655	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
221988003656	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
221988003657	Ca binding site [ion binding]; other site
221988003658	active site
221988003659	catalytic site [active]
221988003660	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
221988003661	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
221988003662	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
221988003663	active site turn [active]
221988003664	phosphorylation site [posttranslational modification]
221988003665	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
221988003666	trehalose repressor; Provisional; Region: treR; PRK09492
221988003667	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
221988003668	DNA binding site [nucleotide binding]
221988003669	domain linker motif; other site
221988003670	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
221988003671	dimerization interface [polypeptide binding]; other site
221988003672	ligand binding site [chemical binding]; other site
221988003673	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
221988003674	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
221988003675	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
221988003676	ABC transporter; Region: ABC_tran_2; pfam12848
221988003677	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
221988003678	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
221988003679	Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709
221988003680	dimerization interface [polypeptide binding]; other site
221988003681	putative ATP binding site [chemical binding]; other site
221988003682	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
221988003683	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
221988003684	DNA binding site [nucleotide binding]
221988003685	domain linker motif; other site
221988003686	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
221988003687	putative ligand binding site [chemical binding]; other site
221988003688	putative dimerization interface [polypeptide binding]; other site
221988003689	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
221988003690	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
221988003691	Hemerythrin-like domain; Region: Hr-like; cd12108
221988003692	Fe binding site [ion binding]; other site
221988003693	sensor protein QseC; Provisional; Region: PRK10337
221988003694	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
221988003695	dimer interface [polypeptide binding]; other site
221988003696	phosphorylation site [posttranslational modification]
221988003697	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
221988003698	ATP binding site [chemical binding]; other site
221988003699	Mg2+ binding site [ion binding]; other site
221988003700	G-X-G motif; other site
221988003701	sensor protein QseC; Provisional; Region: PRK10337
221988003702	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
221988003703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
221988003704	active site
221988003705	phosphorylation site [posttranslational modification]
221988003706	intermolecular recognition site; other site
221988003707	dimerization interface [polypeptide binding]; other site
221988003708	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
221988003709	DNA binding site [nucleotide binding]
221988003710	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
221988003711	hypothetical protein; Provisional; Region: PRK08960
221988003712	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
221988003713	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988003714	homodimer interface [polypeptide binding]; other site
221988003715	catalytic residue [active]
221988003716	sulfite reductase subunit beta; Provisional; Region: PRK13504
221988003717	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
221988003718	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
221988003719	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
221988003720	Flavodoxin; Region: Flavodoxin_1; pfam00258
221988003721	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
221988003722	FAD binding pocket [chemical binding]; other site
221988003723	FAD binding motif [chemical binding]; other site
221988003724	catalytic residues [active]
221988003725	NAD binding pocket [chemical binding]; other site
221988003726	phosphate binding motif [ion binding]; other site
221988003727	beta-alpha-beta structure motif; other site
221988003728	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
221988003729	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
221988003730	CysD dimerization site [polypeptide binding]; other site
221988003731	G1 box; other site
221988003732	putative GEF interaction site [polypeptide binding]; other site
221988003733	GTP/Mg2+ binding site [chemical binding]; other site
221988003734	Switch I region; other site
221988003735	G2 box; other site
221988003736	G3 box; other site
221988003737	Switch II region; other site
221988003738	G4 box; other site
221988003739	G5 box; other site
221988003740	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
221988003741	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
221988003742	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
221988003743	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
221988003744	Active Sites [active]
221988003745	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
221988003746	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
221988003747	Active Sites [active]
221988003748	siroheme synthase; Provisional; Region: cysG; PRK10637
221988003749	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
221988003750	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
221988003751	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
221988003752	active site
221988003753	SAM binding site [chemical binding]; other site
221988003754	homodimer interface [polypeptide binding]; other site
221988003755	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
221988003756	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
221988003757	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
221988003758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988003759	dimer interface [polypeptide binding]; other site
221988003760	conserved gate region; other site
221988003761	putative PBP binding loops; other site
221988003762	ABC-ATPase subunit interface; other site
221988003763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988003764	dimer interface [polypeptide binding]; other site
221988003765	conserved gate region; other site
221988003766	putative PBP binding loops; other site
221988003767	ABC-ATPase subunit interface; other site
221988003768	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
221988003769	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
221988003770	Walker A/P-loop; other site
221988003771	ATP binding site [chemical binding]; other site
221988003772	Q-loop/lid; other site
221988003773	ABC transporter signature motif; other site
221988003774	Walker B; other site
221988003775	D-loop; other site
221988003776	H-loop/switch region; other site
221988003777	TOBE-like domain; Region: TOBE_3; pfam12857
221988003778	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
221988003779	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
221988003780	putative ribose interaction site [chemical binding]; other site
221988003781	putative ADP binding site [chemical binding]; other site
221988003782	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
221988003783	active site
221988003784	nucleotide binding site [chemical binding]; other site
221988003785	HIGH motif; other site
221988003786	KMSKS motif; other site
221988003787	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
221988003788	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
221988003789	putative acyl-acceptor binding pocket; other site
221988003790	hypothetical protein; Provisional; Region: PRK04946
221988003791	Smr domain; Region: Smr; pfam01713
221988003792	HemK family putative methylases; Region: hemK_fam; TIGR00536
221988003793	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988003794	S-adenosylmethionine binding site [chemical binding]; other site
221988003795	malate dehydrogenase; Provisional; Region: PRK05086
221988003796	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
221988003797	NAD binding site [chemical binding]; other site
221988003798	dimerization interface [polypeptide binding]; other site
221988003799	Substrate binding site [chemical binding]; other site
221988003800	arginine repressor; Provisional; Region: PRK05066
221988003801	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
221988003802	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
221988003803	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
221988003804	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
221988003805	putative NAD(P) binding site [chemical binding]; other site
221988003806	putative active site [active]
221988003807	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
221988003808	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
221988003809	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
221988003810	LrgB-like family; Region: LrgB; cl00596
221988003811	hypothetical protein; Provisional; Region: PRK01821
221988003812	Staphylococcal nuclease homologues; Region: SNc; smart00318
221988003813	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
221988003814	Catalytic site; other site
221988003815	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
221988003816	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
221988003817	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
221988003818	catalytic residue [active]
221988003819	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
221988003820	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
221988003821	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
221988003822	Walker A/P-loop; other site
221988003823	ATP binding site [chemical binding]; other site
221988003824	Q-loop/lid; other site
221988003825	ABC transporter signature motif; other site
221988003826	Walker B; other site
221988003827	D-loop; other site
221988003828	H-loop/switch region; other site
221988003829	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
221988003830	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988003831	dimer interface [polypeptide binding]; other site
221988003832	conserved gate region; other site
221988003833	putative PBP binding loops; other site
221988003834	ABC-ATPase subunit interface; other site
221988003835	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
221988003836	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
221988003837	substrate binding pocket [chemical binding]; other site
221988003838	membrane-bound complex binding site; other site
221988003839	hinge residues; other site
221988003840	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
221988003841	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
221988003842	metal binding triad; other site
221988003843	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
221988003844	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
221988003845	metal binding triad; other site
221988003846	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
221988003847	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
221988003848	stringent starvation protein A; Provisional; Region: sspA; PRK09481
221988003849	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
221988003850	C-terminal domain interface [polypeptide binding]; other site
221988003851	putative GSH binding site (G-site) [chemical binding]; other site
221988003852	dimer interface [polypeptide binding]; other site
221988003853	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
221988003854	dimer interface [polypeptide binding]; other site
221988003855	N-terminal domain interface [polypeptide binding]; other site
221988003856	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
221988003857	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
221988003858	23S rRNA interface [nucleotide binding]; other site
221988003859	L3 interface [polypeptide binding]; other site
221988003860	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
221988003861	Protein of unknown function (DUF1043); Region: DUF1043; pfam06295
221988003862	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
221988003863	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
221988003864	putative SAM binding site [chemical binding]; other site
221988003865	putative homodimer interface [polypeptide binding]; other site
221988003866	LppC putative lipoprotein; Region: LppC; pfam04348
221988003867	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
221988003868	putative ligand binding site [chemical binding]; other site
221988003869	hypothetical protein; Reviewed; Region: PRK12497
221988003870	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
221988003871	dimer interface [polypeptide binding]; other site
221988003872	active site
221988003873	outer membrane lipoprotein; Provisional; Region: PRK11023
221988003874	BON domain; Region: BON; pfam04972
221988003875	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
221988003876	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
221988003877	Cation efflux family; Region: Cation_efflux; pfam01545
221988003878	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
221988003879	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
221988003880	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
221988003881	dimer interface [polypeptide binding]; other site
221988003882	active site
221988003883	glycine-pyridoxal phosphate binding site [chemical binding]; other site
221988003884	folate binding site [chemical binding]; other site
221988003885	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
221988003886	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
221988003887	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
221988003888	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
221988003889	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
221988003890	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
221988003891	purine monophosphate binding site [chemical binding]; other site
221988003892	dimer interface [polypeptide binding]; other site
221988003893	putative catalytic residues [active]
221988003894	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
221988003895	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
221988003896	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
221988003897	putative deacylase active site [active]
221988003898	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
221988003899	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
221988003900	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
221988003901	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
221988003902	DsbD alpha interface [polypeptide binding]; other site
221988003903	catalytic residues [active]
221988003904	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
221988003905	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
221988003906	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
221988003907	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
221988003908	HlyD family secretion protein; Region: HlyD_3; pfam13437
221988003909	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
221988003910	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
221988003911	Walker A/P-loop; other site
221988003912	ATP binding site [chemical binding]; other site
221988003913	Q-loop/lid; other site
221988003914	ABC transporter signature motif; other site
221988003915	Walker B; other site
221988003916	D-loop; other site
221988003917	H-loop/switch region; other site
221988003918	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988003919	Walker A/P-loop; other site
221988003920	ATP binding site [chemical binding]; other site
221988003921	Q-loop/lid; other site
221988003922	ABC transporter signature motif; other site
221988003923	Walker B; other site
221988003924	D-loop; other site
221988003925	H-loop/switch region; other site
221988003926	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
221988003927	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
221988003928	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
221988003929	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
221988003930	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
221988003931	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
221988003932	PII uridylyl-transferase; Provisional; Region: glnD; PRK01759
221988003933	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
221988003934	metal binding triad; other site
221988003935	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
221988003936	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
221988003937	Zn2+ binding site [ion binding]; other site
221988003938	Mg2+ binding site [ion binding]; other site
221988003939	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
221988003940	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
221988003941	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
221988003942	active site
221988003943	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
221988003944	Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062
221988003945	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
221988003946	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
221988003947	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
221988003948	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
221988003949	Transglycosylase; Region: Transgly; pfam00912
221988003950	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
221988003951	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
221988003952	Lumazine binding domain; Region: Lum_binding; pfam00677
221988003953	Lumazine binding domain; Region: Lum_binding; pfam00677
221988003954	multidrug efflux protein; Reviewed; Region: PRK01766
221988003955	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
221988003956	cation binding site [ion binding]; other site
221988003957	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
221988003958	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
221988003959	N-terminal plug; other site
221988003960	ligand-binding site [chemical binding]; other site
221988003961	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
221988003962	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
221988003963	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
221988003964	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
221988003965	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
221988003966	DNA binding site [nucleotide binding]
221988003967	domain linker motif; other site
221988003968	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
221988003969	dimerization interface [polypeptide binding]; other site
221988003970	ligand binding site [chemical binding]; other site
221988003971	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
221988003972	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
221988003973	putative valine binding site [chemical binding]; other site
221988003974	dimer interface [polypeptide binding]; other site
221988003975	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
221988003976	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06882
221988003977	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
221988003978	PYR/PP interface [polypeptide binding]; other site
221988003979	dimer interface [polypeptide binding]; other site
221988003980	TPP binding site [chemical binding]; other site
221988003981	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
221988003982	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
221988003983	TPP-binding site [chemical binding]; other site
221988003984	dimer interface [polypeptide binding]; other site
221988003985	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
221988003986	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
221988003987	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
221988003988	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
221988003989	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
221988003990	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
221988003991	putative active site [active]
221988003992	putative substrate binding site [chemical binding]; other site
221988003993	putative cosubstrate binding site; other site
221988003994	catalytic site [active]
221988003995	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
221988003996	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
221988003997	tRNA; other site
221988003998	putative tRNA binding site [nucleotide binding]; other site
221988003999	putative NADP binding site [chemical binding]; other site
221988004000	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
221988004001	putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755
221988004002	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
221988004003	peptide binding site [polypeptide binding]; other site
221988004004	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
221988004005	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
221988004006	putative metal binding site [ion binding]; other site
221988004007	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
221988004008	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
221988004009	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
221988004010	active site
221988004011	HIGH motif; other site
221988004012	KMSK motif region; other site
221988004013	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
221988004014	tRNA binding surface [nucleotide binding]; other site
221988004015	anticodon binding site; other site
221988004016	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
221988004017	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
221988004018	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
221988004019	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
221988004020	NlpC/P60 family; Region: NLPC_P60; pfam00877
221988004021	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
221988004022	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
221988004023	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
221988004024	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
221988004025	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
221988004026	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
221988004027	E3 interaction surface; other site
221988004028	lipoyl attachment site [posttranslational modification]; other site
221988004029	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
221988004030	E3 interaction surface; other site
221988004031	lipoyl attachment site [posttranslational modification]; other site
221988004032	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
221988004033	E3 interaction surface; other site
221988004034	lipoyl attachment site [posttranslational modification]; other site
221988004035	e3 binding domain; Region: E3_binding; pfam02817
221988004036	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
221988004037	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
221988004038	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
221988004039	dimer interface [polypeptide binding]; other site
221988004040	TPP-binding site [chemical binding]; other site
221988004041	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
221988004042	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
221988004043	trimer interface [polypeptide binding]; other site
221988004044	eyelet of channel; other site
221988004045	tellurite resistance protein TehB; Provisional; Region: PRK12335
221988004046	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
221988004047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988004048	S-adenosylmethionine binding site [chemical binding]; other site
221988004049	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
221988004050	putative active site [active]
221988004051	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
221988004052	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988004053	Walker A/P-loop; other site
221988004054	ATP binding site [chemical binding]; other site
221988004055	Q-loop/lid; other site
221988004056	ABC transporter signature motif; other site
221988004057	Walker B; other site
221988004058	D-loop; other site
221988004059	H-loop/switch region; other site
221988004060	molybdenum-pterin binding domain; Region: Mop; TIGR00638
221988004061	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
221988004062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988004063	dimer interface [polypeptide binding]; other site
221988004064	conserved gate region; other site
221988004065	putative PBP binding loops; other site
221988004066	ABC-ATPase subunit interface; other site
221988004067	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
221988004068	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
221988004069	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
221988004070	molybdenum-pterin binding domain; Region: Mop; TIGR00638
221988004071	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
221988004072	CoenzymeA binding site [chemical binding]; other site
221988004073	subunit interaction site [polypeptide binding]; other site
221988004074	PHB binding site; other site
221988004075	ferrochelatase; Reviewed; Region: hemH; PRK00035
221988004076	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
221988004077	C-terminal domain interface [polypeptide binding]; other site
221988004078	active site
221988004079	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
221988004080	active site
221988004081	N-terminal domain interface [polypeptide binding]; other site
221988004082	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
221988004083	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
221988004084	catalytic residue [active]
221988004085	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
221988004086	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
221988004087	dimer interface [polypeptide binding]; other site
221988004088	FMN binding site [chemical binding]; other site
221988004089	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
221988004090	CoA binding domain; Region: CoA_binding; pfam02629
221988004091	CoA-ligase; Region: Ligase_CoA; pfam00549
221988004092	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
221988004093	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
221988004094	CoA-ligase; Region: Ligase_CoA; pfam00549
221988004095	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
221988004096	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
221988004097	E3 interaction surface; other site
221988004098	lipoyl attachment site [posttranslational modification]; other site
221988004099	e3 binding domain; Region: E3_binding; pfam02817
221988004100	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
221988004101	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
221988004102	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
221988004103	TPP-binding site [chemical binding]; other site
221988004104	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
221988004105	dimer interface [polypeptide binding]; other site
221988004106	PYR/PP interface [polypeptide binding]; other site
221988004107	TPP binding site [chemical binding]; other site
221988004108	ribonuclease D; Provisional; Region: PRK10829
221988004109	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
221988004110	catalytic site [active]
221988004111	putative active site [active]
221988004112	putative substrate binding site [chemical binding]; other site
221988004113	HRDC domain; Region: HRDC; pfam00570
221988004114	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
221988004115	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
221988004116	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
221988004117	acyl-activating enzyme (AAE) consensus motif; other site
221988004118	putative AMP binding site [chemical binding]; other site
221988004119	putative active site [active]
221988004120	putative CoA binding site [chemical binding]; other site
221988004121	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
221988004122	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
221988004123	Glycoprotease family; Region: Peptidase_M22; pfam00814
221988004124	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
221988004125	DEAD/DEAH box helicase; Region: DEAD; pfam00270
221988004126	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
221988004127	nucleotide binding region [chemical binding]; other site
221988004128	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
221988004129	active site
221988004130	phosphate binding residues; other site
221988004131	catalytic residues [active]
221988004132	Predicted permeases [General function prediction only]; Region: COG0679
221988004133	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
221988004134	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
221988004135	Walker A/P-loop; other site
221988004136	ATP binding site [chemical binding]; other site
221988004137	Q-loop/lid; other site
221988004138	ABC transporter signature motif; other site
221988004139	Walker B; other site
221988004140	D-loop; other site
221988004141	H-loop/switch region; other site
221988004142	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
221988004143	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
221988004144	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
221988004145	Walker A/P-loop; other site
221988004146	ATP binding site [chemical binding]; other site
221988004147	Q-loop/lid; other site
221988004148	ABC transporter signature motif; other site
221988004149	Walker B; other site
221988004150	D-loop; other site
221988004151	H-loop/switch region; other site
221988004152	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
221988004153	dipeptide transporter; Provisional; Region: PRK10913
221988004154	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
221988004155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988004156	dimer interface [polypeptide binding]; other site
221988004157	conserved gate region; other site
221988004158	putative PBP binding loops; other site
221988004159	ABC-ATPase subunit interface; other site
221988004160	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
221988004161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988004162	dimer interface [polypeptide binding]; other site
221988004163	conserved gate region; other site
221988004164	putative PBP binding loops; other site
221988004165	ABC-ATPase subunit interface; other site
221988004166	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
221988004167	Part of AAA domain; Region: AAA_19; pfam13245
221988004168	Family description; Region: UvrD_C_2; pfam13538
221988004169	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
221988004170	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
221988004171	excinuclease ABC subunit B; Provisional; Region: PRK05298
221988004172	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
221988004173	ATP binding site [chemical binding]; other site
221988004174	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
221988004175	nucleotide binding region [chemical binding]; other site
221988004176	ATP-binding site [chemical binding]; other site
221988004177	Ultra-violet resistance protein B; Region: UvrB; pfam12344
221988004178	UvrB/uvrC motif; Region: UVR; pfam02151
221988004179	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
221988004180	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
221988004181	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
221988004182	serine endoprotease; Provisional; Region: PRK10898
221988004183	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
221988004184	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
221988004185	protein binding site [polypeptide binding]; other site
221988004186	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
221988004187	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
221988004188	catalytic motif [active]
221988004189	Zn binding site [ion binding]; other site
221988004190	RibD C-terminal domain; Region: RibD_C; cl17279
221988004191	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
221988004192	ATP cone domain; Region: ATP-cone; pfam03477
221988004193	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
221988004194	substrate binding site [chemical binding]; other site
221988004195	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
221988004196	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
221988004197	transmembrane helices; other site
221988004198	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
221988004199	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
221988004200	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
221988004201	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
221988004202	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
221988004203	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
221988004204	DNA binding residues [nucleotide binding]
221988004205	putative dimer interface [polypeptide binding]; other site
221988004206	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
221988004207	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
221988004208	substrate binding site [chemical binding]; other site
221988004209	catalytic Zn binding site [ion binding]; other site
221988004210	NAD binding site [chemical binding]; other site
221988004211	structural Zn binding site [ion binding]; other site
221988004212	dimer interface [polypeptide binding]; other site
221988004213	S-formylglutathione hydrolase; Region: PLN02442
221988004214	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
221988004215	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
221988004216	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
221988004217	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
221988004218	AAA domain; Region: AAA_21; pfam13304
221988004219	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988004220	Walker A/P-loop; other site
221988004221	ATP binding site [chemical binding]; other site
221988004222	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
221988004223	putative active site [active]
221988004224	putative metal-binding site [ion binding]; other site
221988004225	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
221988004226	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
221988004227	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988004228	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988004229	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
221988004230	putative effector binding pocket; other site
221988004231	putative dimerization interface [polypeptide binding]; other site
221988004232	SnoaL-like domain; Region: SnoaL_4; pfam13577
221988004233	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
221988004234	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
221988004235	catalytic site [active]
221988004236	recombination factor protein RarA; Reviewed; Region: PRK13342
221988004237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988004238	Walker A motif; other site
221988004239	ATP binding site [chemical binding]; other site
221988004240	Walker B motif; other site
221988004241	arginine finger; other site
221988004242	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
221988004243	SnoaL-like domain; Region: SnoaL_3; pfam13474
221988004244	Helix-turn-helix domain; Region: HTH_18; pfam12833
221988004245	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988004246	Transposase; Region: DEDD_Tnp_IS110; pfam01548
221988004247	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
221988004248	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
221988004249	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
221988004250	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
221988004251	Coenzyme A binding pocket [chemical binding]; other site
221988004252	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
221988004253	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988004254	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461
221988004255	putative substrate binding pocket [chemical binding]; other site
221988004256	putative dimerization interface [polypeptide binding]; other site
221988004257	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
221988004258	hydrophobic ligand binding site; other site
221988004259	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
221988004260	NADH(P)-binding; Region: NAD_binding_10; pfam13460
221988004261	NAD(P) binding site [chemical binding]; other site
221988004262	active site
221988004263	short chain dehydrogenase; Provisional; Region: PRK06940
221988004264	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
221988004265	NAD(P) binding site [chemical binding]; other site
221988004266	active site
221988004267	Major Facilitator Superfamily; Region: MFS_1; pfam07690
221988004268	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988004269	putative substrate translocation pore; other site
221988004270	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
221988004271	HPr interaction site; other site
221988004272	glycerol kinase (GK) interaction site [polypeptide binding]; other site
221988004273	active site
221988004274	phosphorylation site [posttranslational modification]
221988004275	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
221988004276	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
221988004277	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
221988004278	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
221988004279	putative N- and C-terminal domain interface [polypeptide binding]; other site
221988004280	putative active site [active]
221988004281	MgATP binding site [chemical binding]; other site
221988004282	catalytic site [active]
221988004283	metal binding site [ion binding]; metal-binding site
221988004284	putative carbohydrate binding site [chemical binding]; other site
221988004285	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
221988004286	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
221988004287	NAD(P) binding site [chemical binding]; other site
221988004288	active site
221988004289	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
221988004290	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
221988004291	nucleotide binding site [chemical binding]; other site
221988004292	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
221988004293	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
221988004294	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
221988004295	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988004296	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988004297	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
221988004298	dimerization interface [polypeptide binding]; other site
221988004299	YCII-related domain; Region: YCII; cl00999
221988004300	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
221988004301	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
221988004302	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
221988004303	active site
221988004304	catalytic tetrad [active]
221988004305	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
221988004306	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
221988004307	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
221988004308	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
221988004309	classical (c) SDRs; Region: SDR_c; cd05233
221988004310	NAD(P) binding site [chemical binding]; other site
221988004311	active site
221988004312	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
221988004313	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
221988004314	active site
221988004315	catalytic tetrad [active]
221988004316	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
221988004317	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
221988004318	potential catalytic triad [active]
221988004319	conserved cys residue [active]
221988004320	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
221988004321	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
221988004322	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
221988004323	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
221988004324	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
221988004325	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
221988004326	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
221988004327	Uncharacterized conserved protein [Function unknown]; Region: COG1359
221988004328	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
221988004329	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
221988004330	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
221988004331	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
221988004332	DNA binding residues [nucleotide binding]
221988004333	dimer interface [polypeptide binding]; other site
221988004334	putative metal binding site [ion binding]; other site
221988004335	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
221988004336	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
221988004337	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
221988004338	active site
221988004339	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
221988004340	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
221988004341	ATP binding site [chemical binding]; other site
221988004342	putative Mg++ binding site [ion binding]; other site
221988004343	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
221988004344	nucleotide binding region [chemical binding]; other site
221988004345	ATP-binding site [chemical binding]; other site
221988004346	Helicase associated domain (HA2); Region: HA2; pfam04408
221988004347	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
221988004348	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
221988004349	Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503
221988004350	Predicted membrane protein [Function unknown]; Region: COG2707
221988004351	Membrane transport protein; Region: Mem_trans; cl09117
221988004352	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
221988004353	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
221988004354	RNA binding site [nucleotide binding]; other site
221988004355	active site
221988004356	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
221988004357	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
221988004358	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
221988004359	translation initiation factor IF-2; Region: IF-2; TIGR00487
221988004360	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
221988004361	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
221988004362	G1 box; other site
221988004363	putative GEF interaction site [polypeptide binding]; other site
221988004364	GTP/Mg2+ binding site [chemical binding]; other site
221988004365	Switch I region; other site
221988004366	G2 box; other site
221988004367	G3 box; other site
221988004368	Switch II region; other site
221988004369	G4 box; other site
221988004370	G5 box; other site
221988004371	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
221988004372	Translation-initiation factor 2; Region: IF-2; pfam11987
221988004373	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
221988004374	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
221988004375	NusA N-terminal domain; Region: NusA_N; pfam08529
221988004376	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
221988004377	RNA binding site [nucleotide binding]; other site
221988004378	homodimer interface [polypeptide binding]; other site
221988004379	NusA-like KH domain; Region: KH_5; pfam13184
221988004380	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
221988004381	G-X-X-G motif; other site
221988004382	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
221988004383	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
221988004384	ribosome maturation protein RimP; Reviewed; Region: PRK00092
221988004385	Sm and related proteins; Region: Sm_like; cl00259
221988004386	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
221988004387	putative oligomer interface [polypeptide binding]; other site
221988004388	putative RNA binding site [nucleotide binding]; other site
221988004389	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
221988004390	active site
221988004391	substrate binding site [chemical binding]; other site
221988004392	ATP binding site [chemical binding]; other site
221988004393	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
221988004394	seryl-tRNA synthetase; Provisional; Region: PRK05431
221988004395	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
221988004396	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
221988004397	dimer interface [polypeptide binding]; other site
221988004398	active site
221988004399	motif 1; other site
221988004400	motif 2; other site
221988004401	motif 3; other site
221988004402	recombination factor protein RarA; Reviewed; Region: PRK13342
221988004403	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988004404	Walker A motif; other site
221988004405	ATP binding site [chemical binding]; other site
221988004406	Walker B motif; other site
221988004407	arginine finger; other site
221988004408	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
221988004409	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
221988004410	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
221988004411	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
221988004412	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
221988004413	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
221988004414	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
221988004415	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
221988004416	dimerization interface [polypeptide binding]; other site
221988004417	putative DNA binding site [nucleotide binding]; other site
221988004418	putative Zn2+ binding site [ion binding]; other site
221988004419	AsnC family; Region: AsnC_trans_reg; pfam01037
221988004420	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
221988004421	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
221988004422	metal binding site [ion binding]; metal-binding site
221988004423	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
221988004424	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
221988004425	putative ATP binding site [chemical binding]; other site
221988004426	putative substrate interface [chemical binding]; other site
221988004427	murein transglycosylase A; Provisional; Region: mltA; PRK11162
221988004428	MltA specific insert domain; Region: MltA; smart00925
221988004429	3D domain; Region: 3D; pfam06725
221988004430	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
221988004431	dimerization interface [polypeptide binding]; other site
221988004432	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
221988004433	ATP binding site [chemical binding]; other site
221988004434	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
221988004435	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
221988004436	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
221988004437	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
221988004438	Uncharacterized conserved protein [Function unknown]; Region: COG0327
221988004439	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
221988004440	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
221988004441	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
221988004442	homotetramer interface [polypeptide binding]; other site
221988004443	NAD binding site [chemical binding]; other site
221988004444	homodimer interface [polypeptide binding]; other site
221988004445	substrate binding site [chemical binding]; other site
221988004446	active site
221988004447	exoribonuclease II; Provisional; Region: PRK05054
221988004448	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
221988004449	RNB domain; Region: RNB; pfam00773
221988004450	S1 RNA binding domain; Region: S1; pfam00575
221988004451	RNA binding site [nucleotide binding]; other site
221988004452	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
221988004453	translation initiation factor Sui1; Validated; Region: PRK06824
221988004454	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
221988004455	putative rRNA binding site [nucleotide binding]; other site
221988004456	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
221988004457	active site
221988004458	dimer interface [polypeptide binding]; other site
221988004459	tetratricopeptide repeat protein; Provisional; Region: PRK11788
221988004460	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
221988004461	binding surface
221988004462	TPR motif; other site
221988004463	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
221988004464	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
221988004465	IHF dimer interface [polypeptide binding]; other site
221988004466	IHF - DNA interface [nucleotide binding]; other site
221988004467	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
221988004468	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
221988004469	RNA binding site [nucleotide binding]; other site
221988004470	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
221988004471	RNA binding site [nucleotide binding]; other site
221988004472	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
221988004473	RNA binding site [nucleotide binding]; other site
221988004474	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
221988004475	RNA binding site [nucleotide binding]; other site
221988004476	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
221988004477	RNA binding site [nucleotide binding]; other site
221988004478	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
221988004479	RNA binding site [nucleotide binding]; other site
221988004480	cytidylate kinase; Provisional; Region: cmk; PRK00023
221988004481	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
221988004482	CMP-binding site; other site
221988004483	The sites determining sugar specificity; other site
221988004484	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
221988004485	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
221988004486	argininosuccinate synthase; Validated; Region: PRK05370
221988004487	argininosuccinate synthase; Provisional; Region: PRK13820
221988004488	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
221988004489	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
221988004490	putative NAD(P) binding site [chemical binding]; other site
221988004491	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
221988004492	ATP binding site [chemical binding]; other site
221988004493	active site
221988004494	substrate binding site [chemical binding]; other site
221988004495	tyrosine kinase; Provisional; Region: PRK11519
221988004496	Chain length determinant protein; Region: Wzz; pfam02706
221988004497	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
221988004498	polysaccharide export protein Wza; Provisional; Region: PRK15078
221988004499	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
221988004500	SLBB domain; Region: SLBB; pfam10531
221988004501	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
221988004502	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
221988004503	NAD(P) binding site [chemical binding]; other site
221988004504	homodimer interface [polypeptide binding]; other site
221988004505	substrate binding site [chemical binding]; other site
221988004506	active site
221988004507	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
221988004508	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
221988004509	inhibitor-cofactor binding pocket; inhibition site
221988004510	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988004511	catalytic residue [active]
221988004512	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
221988004513	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
221988004514	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
221988004515	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
221988004516	Bacterial sugar transferase; Region: Bac_transf; pfam02397
221988004517	O-Antigen ligase; Region: Wzy_C; pfam04932
221988004518	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
221988004519	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
221988004520	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
221988004521	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
221988004522	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
221988004523	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
221988004524	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
221988004525	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
221988004526	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
221988004527	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
221988004528	inhibitor-cofactor binding pocket; inhibition site
221988004529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988004530	catalytic residue [active]
221988004531	putative trimer interface [polypeptide binding]; other site
221988004532	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
221988004533	putative CoA binding site [chemical binding]; other site
221988004534	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
221988004535	putative trimer interface [polypeptide binding]; other site
221988004536	putative active site [active]
221988004537	putative substrate binding site [chemical binding]; other site
221988004538	putative CoA binding site [chemical binding]; other site
221988004539	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
221988004540	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
221988004541	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
221988004542	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
221988004543	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
221988004544	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
221988004545	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
221988004546	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
221988004547	G1 box; other site
221988004548	putative GEF interaction site [polypeptide binding]; other site
221988004549	GTP/Mg2+ binding site [chemical binding]; other site
221988004550	Switch I region; other site
221988004551	G2 box; other site
221988004552	G3 box; other site
221988004553	Switch II region; other site
221988004554	G4 box; other site
221988004555	G5 box; other site
221988004556	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
221988004557	two-component response regulator; Provisional; Region: PRK11173
221988004558	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
221988004559	active site
221988004560	phosphorylation site [posttranslational modification]
221988004561	intermolecular recognition site; other site
221988004562	dimerization interface [polypeptide binding]; other site
221988004563	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
221988004564	DNA binding site [nucleotide binding]
221988004565	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
221988004566	SmpB-tmRNA interface; other site
221988004567	recombination protein RecR; Reviewed; Region: recR; PRK00076
221988004568	RecR protein; Region: RecR; pfam02132
221988004569	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
221988004570	putative active site [active]
221988004571	putative metal-binding site [ion binding]; other site
221988004572	tetramer interface [polypeptide binding]; other site
221988004573	hypothetical protein; Validated; Region: PRK00153
221988004574	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
221988004575	HPr interaction site; other site
221988004576	glycerol kinase (GK) interaction site [polypeptide binding]; other site
221988004577	active site
221988004578	phosphorylation site [posttranslational modification]
221988004579	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
221988004580	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
221988004581	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
221988004582	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
221988004583	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
221988004584	dimerization domain swap beta strand [polypeptide binding]; other site
221988004585	regulatory protein interface [polypeptide binding]; other site
221988004586	active site
221988004587	regulatory phosphorylation site [posttranslational modification]; other site
221988004588	GTPase RsgA; Reviewed; Region: PRK12288
221988004589	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
221988004590	RNA binding site [nucleotide binding]; other site
221988004591	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
221988004592	GTPase/Zn-binding domain interface [polypeptide binding]; other site
221988004593	GTP/Mg2+ binding site [chemical binding]; other site
221988004594	G4 box; other site
221988004595	G5 box; other site
221988004596	G1 box; other site
221988004597	Switch I region; other site
221988004598	G2 box; other site
221988004599	G3 box; other site
221988004600	Switch II region; other site
221988004601	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
221988004602	catalytic site [active]
221988004603	putative active site [active]
221988004604	putative substrate binding site [chemical binding]; other site
221988004605	dimer interface [polypeptide binding]; other site
221988004606	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
221988004607	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
221988004608	active site
221988004609	metal binding site [ion binding]; metal-binding site
221988004610	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
221988004611	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
221988004612	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
221988004613	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
221988004614	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
221988004615	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
221988004616	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
221988004617	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
221988004618	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
221988004619	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
221988004620	ATP binding site [chemical binding]; other site
221988004621	Mg2+ binding site [ion binding]; other site
221988004622	G-X-G motif; other site
221988004623	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
221988004624	ATP binding site [chemical binding]; other site
221988004625	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
221988004626	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
221988004627	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
221988004628	bacterial Hfq-like; Region: Hfq; cd01716
221988004629	hexamer interface [polypeptide binding]; other site
221988004630	Sm1 motif; other site
221988004631	RNA binding site [nucleotide binding]; other site
221988004632	Sm2 motif; other site
221988004633	GTPase HflX; Provisional; Region: PRK11058
221988004634	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
221988004635	HflX GTPase family; Region: HflX; cd01878
221988004636	G1 box; other site
221988004637	GTP/Mg2+ binding site [chemical binding]; other site
221988004638	Switch I region; other site
221988004639	G2 box; other site
221988004640	G3 box; other site
221988004641	Switch II region; other site
221988004642	G4 box; other site
221988004643	G5 box; other site
221988004644	cystathionine beta-lyase; Provisional; Region: PRK08114
221988004645	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
221988004646	homodimer interface [polypeptide binding]; other site
221988004647	substrate-cofactor binding pocket; other site
221988004648	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988004649	catalytic residue [active]
221988004650	peroxidase; Provisional; Region: PRK15000
221988004651	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
221988004652	dimer interface [polypeptide binding]; other site
221988004653	decamer (pentamer of dimers) interface [polypeptide binding]; other site
221988004654	catalytic triad [active]
221988004655	peroxidatic and resolving cysteines [active]
221988004656	Protein of unknown function, DUF488; Region: DUF488; cl01246
221988004657	biotin synthase; Region: bioB; TIGR00433
221988004658	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988004659	FeS/SAM binding site; other site
221988004660	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
221988004661	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
221988004662	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
221988004663	Walker A/P-loop; other site
221988004664	ATP binding site [chemical binding]; other site
221988004665	Q-loop/lid; other site
221988004666	ABC transporter signature motif; other site
221988004667	Walker B; other site
221988004668	D-loop; other site
221988004669	H-loop/switch region; other site
221988004670	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
221988004671	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988004672	dimer interface [polypeptide binding]; other site
221988004673	conserved gate region; other site
221988004674	putative PBP binding loops; other site
221988004675	ABC-ATPase subunit interface; other site
221988004676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988004677	dimer interface [polypeptide binding]; other site
221988004678	conserved gate region; other site
221988004679	putative PBP binding loops; other site
221988004680	ABC-ATPase subunit interface; other site
221988004681	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
221988004682	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
221988004683	fructokinase; Reviewed; Region: PRK09557
221988004684	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
221988004685	nucleotide binding site [chemical binding]; other site
221988004686	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
221988004687	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
221988004688	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
221988004689	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
221988004690	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
221988004691	Metal-binding active site; metal-binding site
221988004692	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
221988004693	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
221988004694	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988004695	putative substrate translocation pore; other site
221988004696	Transcriptional regulators [Transcription]; Region: PurR; COG1609
221988004697	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
221988004698	DNA binding site [nucleotide binding]
221988004699	domain linker motif; other site
221988004700	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
221988004701	dimerization interface [polypeptide binding]; other site
221988004702	ligand binding site [chemical binding]; other site
221988004703	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
221988004704	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
221988004705	active site
221988004706	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
221988004707	dimerization interface [polypeptide binding]; other site
221988004708	active site
221988004709	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
221988004710	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
221988004711	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
221988004712	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
221988004713	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
221988004714	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
221988004715	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
221988004716	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
221988004717	active site
221988004718	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
221988004719	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
221988004720	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
221988004721	catalytic residues [active]
221988004722	alpha helical domain; other site
221988004723	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
221988004724	DHH family; Region: DHH; pfam01368
221988004725	DHHA1 domain; Region: DHHA1; pfam02272
221988004726	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
221988004727	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
221988004728	dimerization domain [polypeptide binding]; other site
221988004729	dimer interface [polypeptide binding]; other site
221988004730	catalytic residues [active]
221988004731	peptide chain release factor 2; Provisional; Region: PRK08787
221988004732	This domain is found in peptide chain release factors; Region: PCRF; smart00937
221988004733	RF-1 domain; Region: RF-1; pfam00472
221988004734	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
221988004735	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
221988004736	dimer interface [polypeptide binding]; other site
221988004737	putative anticodon binding site; other site
221988004738	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
221988004739	motif 1; other site
221988004740	active site
221988004741	motif 2; other site
221988004742	motif 3; other site
221988004743	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
221988004744	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
221988004745	Acylphosphatase; Region: Acylphosphatase; pfam00708
221988004746	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
221988004747	HypF finger; Region: zf-HYPF; pfam07503
221988004748	HypF finger; Region: zf-HYPF; pfam07503
221988004749	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
221988004750	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
221988004751	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
221988004752	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
221988004753	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
221988004754	multifunctional aminopeptidase A; Provisional; Region: PRK00913
221988004755	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
221988004756	interface (dimer of trimers) [polypeptide binding]; other site
221988004757	Substrate-binding/catalytic site; other site
221988004758	Zn-binding sites [ion binding]; other site
221988004759	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
221988004760	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
221988004761	NAD(P) binding site [chemical binding]; other site
221988004762	catalytic residues [active]
221988004763	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
221988004764	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
221988004765	putative metal binding site [ion binding]; other site
221988004766	dimer interface [polypeptide binding]; other site
221988004767	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
221988004768	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
221988004769	allantoate amidohydrolase; Reviewed; Region: PRK09290
221988004770	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
221988004771	active site
221988004772	metal binding site [ion binding]; metal-binding site
221988004773	dimer interface [polypeptide binding]; other site
221988004774	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
221988004775	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
221988004776	HIGH motif; other site
221988004777	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
221988004778	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
221988004779	active site
221988004780	KMSKS motif; other site
221988004781	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
221988004782	tRNA binding surface [nucleotide binding]; other site
221988004783	anticodon binding site; other site
221988004784	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
221988004785	DNA polymerase III subunit chi; Validated; Region: PRK05728
221988004786	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
221988004787	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
221988004788	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
221988004789	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
221988004790	Hemerythrin-like domain; Region: Hr-like; cd12108
221988004791	Fe binding site [ion binding]; other site
221988004792	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
221988004793	CPxP  motif; other site
221988004794	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
221988004795	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
221988004796	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
221988004797	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
221988004798	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
221988004799	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
221988004800	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
221988004801	Protein export membrane protein; Region: SecD_SecF; pfam02355
221988004802	lytic murein transglycosylase; Provisional; Region: PRK11619
221988004803	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
221988004804	N-acetyl-D-glucosamine binding site [chemical binding]; other site
221988004805	catalytic residue [active]
221988004806	Trp operon repressor; Provisional; Region: PRK01381
221988004807	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
221988004808	Transglycosylase; Region: Transgly; cl17702
221988004809	malonic semialdehyde reductase; Provisional; Region: PRK10538
221988004810	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
221988004811	putative NAD(P) binding site [chemical binding]; other site
221988004812	homotetramer interface [polypeptide binding]; other site
221988004813	homodimer interface [polypeptide binding]; other site
221988004814	active site
221988004815	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
221988004816	Sulfatase; Region: Sulfatase; pfam00884
221988004817	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
221988004818	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
221988004819	active site
221988004820	catalytic site [active]
221988004821	substrate binding site [chemical binding]; other site
221988004822	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
221988004823	RNA/DNA hybrid binding site [nucleotide binding]; other site
221988004824	active site
221988004825	hypothetical protein; Provisional; Region: PRK05423
221988004826	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
221988004827	homodimer interface [polypeptide binding]; other site
221988004828	substrate-cofactor binding pocket; other site
221988004829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988004830	catalytic residue [active]
221988004831	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
221988004832	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
221988004833	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988004834	homodimer interface [polypeptide binding]; other site
221988004835	catalytic residue [active]
221988004836	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
221988004837	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
221988004838	hinge; other site
221988004839	active site
221988004840	putative transposase OrfB; Reviewed; Region: PHA02517
221988004841	HTH-like domain; Region: HTH_21; pfam13276
221988004842	Integrase core domain; Region: rve; pfam00665
221988004843	Integrase core domain; Region: rve_3; pfam13683
221988004844	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
221988004845	Transposase; Region: HTH_Tnp_1; pfam01527
221988004846	putative arabinose transporter; Provisional; Region: PRK03545
221988004847	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988004848	putative substrate translocation pore; other site
221988004849	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
221988004850	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
221988004851	trimer interface [polypeptide binding]; other site
221988004852	active site
221988004853	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
221988004854	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
221988004855	Sugar specificity; other site
221988004856	Pyrimidine base specificity; other site
221988004857	ATP-binding site [chemical binding]; other site
221988004858	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
221988004859	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
221988004860	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
221988004861	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
221988004862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988004863	dimer interface [polypeptide binding]; other site
221988004864	conserved gate region; other site
221988004865	putative PBP binding loops; other site
221988004866	ABC-ATPase subunit interface; other site
221988004867	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988004868	dimer interface [polypeptide binding]; other site
221988004869	conserved gate region; other site
221988004870	putative PBP binding loops; other site
221988004871	ABC-ATPase subunit interface; other site
221988004872	ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432
221988004873	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
221988004874	Walker A/P-loop; other site
221988004875	ATP binding site [chemical binding]; other site
221988004876	Q-loop/lid; other site
221988004877	ABC transporter signature motif; other site
221988004878	Walker B; other site
221988004879	D-loop; other site
221988004880	H-loop/switch region; other site
221988004881	TOBE domain; Region: TOBE_2; pfam08402
221988004882	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
221988004883	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
221988004884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988004885	S-adenosylmethionine binding site [chemical binding]; other site
221988004886	DNA polymerase III subunit psi; Validated; Region: PRK06856
221988004887	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
221988004888	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
221988004889	Coenzyme A binding pocket [chemical binding]; other site
221988004890	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
221988004891	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
221988004892	dimer interface [polypeptide binding]; other site
221988004893	active site
221988004894	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
221988004895	Uncharacterized conserved protein [Function unknown]; Region: COG4121
221988004896	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
221988004897	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
221988004898	NAD binding site [chemical binding]; other site
221988004899	substrate binding site [chemical binding]; other site
221988004900	homodimer interface [polypeptide binding]; other site
221988004901	active site
221988004902	GTPase CgtA; Reviewed; Region: obgE; PRK12298
221988004903	GTP1/OBG; Region: GTP1_OBG; pfam01018
221988004904	Obg GTPase; Region: Obg; cd01898
221988004905	G1 box; other site
221988004906	GTP/Mg2+ binding site [chemical binding]; other site
221988004907	Switch I region; other site
221988004908	G2 box; other site
221988004909	G3 box; other site
221988004910	Switch II region; other site
221988004911	G4 box; other site
221988004912	G5 box; other site
221988004913	EamA-like transporter family; Region: EamA; pfam00892
221988004914	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
221988004915	EamA-like transporter family; Region: EamA; pfam00892
221988004916	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
221988004917	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
221988004918	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
221988004919	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
221988004920	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
221988004921	substrate binding pocket [chemical binding]; other site
221988004922	chain length determination region; other site
221988004923	substrate-Mg2+ binding site; other site
221988004924	catalytic residues [active]
221988004925	aspartate-rich region 1; other site
221988004926	active site lid residues [active]
221988004927	aspartate-rich region 2; other site
221988004928	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
221988004929	putative transposase OrfB; Reviewed; Region: PHA02517
221988004930	HTH-like domain; Region: HTH_21; pfam13276
221988004931	Integrase core domain; Region: rve; pfam00665
221988004932	Integrase core domain; Region: rve_3; pfam13683
221988004933	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
221988004934	Transposase; Region: HTH_Tnp_1; pfam01527
221988004935	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
221988004936	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
221988004937	putative catalytic cysteine [active]
221988004938	Predicted membrane protein [Function unknown]; Region: COG2860
221988004939	UPF0126 domain; Region: UPF0126; pfam03458
221988004940	UPF0126 domain; Region: UPF0126; pfam03458
221988004941	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
221988004942	Dak1 domain; Region: Dak1; pfam02733
221988004943	dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005
221988004944	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
221988004945	active pocket/dimerization site; other site
221988004946	active site
221988004947	phosphorylation site [posttranslational modification]
221988004948	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
221988004949	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
221988004950	putative N- and C-terminal domain interface [polypeptide binding]; other site
221988004951	putative active site [active]
221988004952	MgATP binding site [chemical binding]; other site
221988004953	catalytic site [active]
221988004954	metal binding site [ion binding]; metal-binding site
221988004955	putative xylulose binding site [chemical binding]; other site
221988004956	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
221988004957	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
221988004958	TM-ABC transporter signature motif; other site
221988004959	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
221988004960	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
221988004961	Walker A/P-loop; other site
221988004962	ATP binding site [chemical binding]; other site
221988004963	Q-loop/lid; other site
221988004964	ABC transporter signature motif; other site
221988004965	Walker B; other site
221988004966	D-loop; other site
221988004967	H-loop/switch region; other site
221988004968	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
221988004969	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
221988004970	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
221988004971	ligand binding site [chemical binding]; other site
221988004972	aspartate kinase III; Validated; Region: PRK09084
221988004973	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
221988004974	nucleotide binding site [chemical binding]; other site
221988004975	substrate binding site [chemical binding]; other site
221988004976	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
221988004977	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
221988004978	dimer interface [polypeptide binding]; other site
221988004979	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
221988004980	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
221988004981	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
221988004982	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
221988004983	AMP binding site [chemical binding]; other site
221988004984	metal binding site [ion binding]; metal-binding site
221988004985	active site
221988004986	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
221988004987	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
221988004988	putative C-terminal domain interface [polypeptide binding]; other site
221988004989	putative GSH binding site (G-site) [chemical binding]; other site
221988004990	putative dimer interface [polypeptide binding]; other site
221988004991	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
221988004992	putative N-terminal domain interface [polypeptide binding]; other site
221988004993	putative dimer interface [polypeptide binding]; other site
221988004994	putative substrate binding pocket (H-site) [chemical binding]; other site
221988004995	FtsH protease regulator HflK; Provisional; Region: PRK10930
221988004996	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
221988004997	FtsH protease regulator HflC; Provisional; Region: PRK11029
221988004998	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
221988004999	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
221988005000	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
221988005001	GDP-binding site [chemical binding]; other site
221988005002	ACT binding site; other site
221988005003	IMP binding site; other site
221988005004	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
221988005005	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
221988005006	homodimer interface [polypeptide binding]; other site
221988005007	oligonucleotide binding site [chemical binding]; other site
221988005008	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
221988005009	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
221988005010	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
221988005011	RNA binding surface [nucleotide binding]; other site
221988005012	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
221988005013	active site
221988005014	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
221988005015	catalytic residues [active]
221988005016	cystathionine gamma-synthase; Reviewed; Region: PRK08247
221988005017	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
221988005018	homodimer interface [polypeptide binding]; other site
221988005019	substrate-cofactor binding pocket; other site
221988005020	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988005021	catalytic residue [active]
221988005022	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
221988005023	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
221988005024	putative active site [active]
221988005025	putative metal binding site [ion binding]; other site
221988005026	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
221988005027	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
221988005028	active site
221988005029	HIGH motif; other site
221988005030	KMSKS motif; other site
221988005031	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
221988005032	tRNA binding surface [nucleotide binding]; other site
221988005033	anticodon binding site; other site
221988005034	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
221988005035	dimer interface [polypeptide binding]; other site
221988005036	putative tRNA-binding site [nucleotide binding]; other site
221988005037	antiporter inner membrane protein; Provisional; Region: PRK11670
221988005038	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
221988005039	Walker A motif; other site
221988005040	poxB regulator PoxA; Provisional; Region: PRK09350
221988005041	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
221988005042	motif 1; other site
221988005043	dimer interface [polypeptide binding]; other site
221988005044	active site
221988005045	motif 2; other site
221988005046	motif 3; other site
221988005047	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
221988005048	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
221988005049	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
221988005050	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741
221988005051	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
221988005052	CRISPR/Cas system-associated protein Csx16; Region: Csx16_III-U; cd09695
221988005053	Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040
221988005054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
221988005055	Transposase; Region: DDE_Tnp_ISL3; pfam01610
221988005056	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
221988005057	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
221988005058	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
221988005059	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
221988005060	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
221988005061	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
221988005062	L-aspartate oxidase; Provisional; Region: PRK06175
221988005063	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
221988005064	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
221988005065	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
221988005066	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
221988005067	D-subunit interface [polypeptide binding]; other site
221988005068	Iron-sulfur protein interface; other site
221988005069	proximal quinone binding site [chemical binding]; other site
221988005070	distal quinone binding site [chemical binding]; other site
221988005071	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
221988005072	Iron-sulfur protein interface; other site
221988005073	proximal quinone binding site [chemical binding]; other site
221988005074	C-subunit interface; other site
221988005075	distal quinone binding site; other site
221988005076	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
221988005077	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
221988005078	Prephenate dehydratase; Region: PDT; pfam00800
221988005079	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
221988005080	putative L-Phe binding site [chemical binding]; other site
221988005081	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
221988005082	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
221988005083	active site
221988005084	metal binding site [ion binding]; metal-binding site
221988005085	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
221988005086	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
221988005087	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
221988005088	cell division protein FtsZ; Validated; Region: PRK09330
221988005089	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
221988005090	nucleotide binding site [chemical binding]; other site
221988005091	SulA interaction site; other site
221988005092	cell division protein FtsA; Region: ftsA; TIGR01174
221988005093	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
221988005094	nucleotide binding site [chemical binding]; other site
221988005095	Cell division protein FtsA; Region: FtsA; pfam14450
221988005096	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
221988005097	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
221988005098	Cell division protein FtsQ; Region: FtsQ; pfam03799
221988005099	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
221988005100	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
221988005101	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
221988005102	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
221988005103	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
221988005104	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
221988005105	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
221988005106	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
221988005107	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
221988005108	active site
221988005109	homodimer interface [polypeptide binding]; other site
221988005110	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
221988005111	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
221988005112	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
221988005113	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
221988005114	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
221988005115	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
221988005116	Mg++ binding site [ion binding]; other site
221988005117	putative catalytic motif [active]
221988005118	putative substrate binding site [chemical binding]; other site
221988005119	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
221988005120	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
221988005121	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
221988005122	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
221988005123	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
221988005124	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
221988005125	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
221988005126	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
221988005127	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
221988005128	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
221988005129	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
221988005130	Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116
221988005131	MraW methylase family; Region: Methyltransf_5; pfam01795
221988005132	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
221988005133	cell division protein MraZ; Reviewed; Region: PRK00326
221988005134	MraZ protein; Region: MraZ; pfam02381
221988005135	MraZ protein; Region: MraZ; pfam02381
221988005136	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
221988005137	Carbon starvation protein CstA; Region: CstA; pfam02554
221988005138	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
221988005139	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
221988005140	Helicase; Region: Helicase_RecD; pfam05127
221988005141	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
221988005142	Coenzyme A binding pocket [chemical binding]; other site
221988005143	metal-binding heat shock protein; Provisional; Region: PRK00016
221988005144	LysE type translocator; Region: LysE; cl00565
221988005145	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
221988005146	PhoH-like protein; Region: PhoH; pfam02562
221988005147	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
221988005148	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
221988005149	ATP-grasp domain; Region: ATP-grasp_4; cl17255
221988005150	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
221988005151	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
221988005152	substrate binding pocket [chemical binding]; other site
221988005153	membrane-bound complex binding site; other site
221988005154	hinge residues; other site
221988005155	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
221988005156	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
221988005157	Walker A/P-loop; other site
221988005158	ATP binding site [chemical binding]; other site
221988005159	Q-loop/lid; other site
221988005160	ABC transporter signature motif; other site
221988005161	Walker B; other site
221988005162	D-loop; other site
221988005163	H-loop/switch region; other site
221988005164	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
221988005165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988005166	dimer interface [polypeptide binding]; other site
221988005167	conserved gate region; other site
221988005168	putative PBP binding loops; other site
221988005169	ABC-ATPase subunit interface; other site
221988005170	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
221988005171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988005172	dimer interface [polypeptide binding]; other site
221988005173	conserved gate region; other site
221988005174	putative PBP binding loops; other site
221988005175	ABC-ATPase subunit interface; other site
221988005176	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988005177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988005178	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
221988005179	dimerization interface [polypeptide binding]; other site
221988005180	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
221988005181	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
221988005182	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988005183	FeS/SAM binding site; other site
221988005184	TRAM domain; Region: TRAM; pfam01938
221988005185	Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977
221988005186	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
221988005187	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
221988005188	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
221988005189	active site
221988005190	metal binding site [ion binding]; metal-binding site
221988005191	hexamer interface [polypeptide binding]; other site
221988005192	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
221988005193	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
221988005194	dimer interface [polypeptide binding]; other site
221988005195	ADP-ribose binding site [chemical binding]; other site
221988005196	active site
221988005197	nudix motif; other site
221988005198	metal binding site [ion binding]; metal-binding site
221988005199	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
221988005200	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
221988005201	heat shock protein 90; Provisional; Region: PRK05218
221988005202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
221988005203	ATP binding site [chemical binding]; other site
221988005204	Mg2+ binding site [ion binding]; other site
221988005205	G-X-G motif; other site
221988005206	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
221988005207	hypothetical protein; Provisional; Region: PRK04860
221988005208	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
221988005209	threonine synthase; Validated; Region: PRK09225
221988005210	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
221988005211	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
221988005212	catalytic residue [active]
221988005213	homoserine kinase; Provisional; Region: PRK01212
221988005214	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
221988005215	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
221988005216	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
221988005217	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
221988005218	nucleotide binding site [chemical binding]; other site
221988005219	substrate binding site [chemical binding]; other site
221988005220	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
221988005221	dimer interface [polypeptide binding]; other site
221988005222	putative threonine allosteric regulatory site; other site
221988005223	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
221988005224	putative threonine allosteric regulatory site; other site
221988005225	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
221988005226	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
221988005227	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
221988005228	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
221988005229	E-class dimer interface [polypeptide binding]; other site
221988005230	P-class dimer interface [polypeptide binding]; other site
221988005231	active site
221988005232	Cu2+ binding site [ion binding]; other site
221988005233	Zn2+ binding site [ion binding]; other site
221988005234	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
221988005235	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
221988005236	catalytic residue [active]
221988005237	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
221988005238	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
221988005239	hinge; other site
221988005240	active site
221988005241	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
221988005242	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
221988005243	anti sigma factor interaction site; other site
221988005244	regulatory phosphorylation site [posttranslational modification]; other site
221988005245	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
221988005246	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
221988005247	mce related protein; Region: MCE; pfam02470
221988005248	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
221988005249	conserved hypothetical integral membrane protein; Region: TIGR00056
221988005250	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
221988005251	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
221988005252	Walker A/P-loop; other site
221988005253	ATP binding site [chemical binding]; other site
221988005254	Q-loop/lid; other site
221988005255	ABC transporter signature motif; other site
221988005256	Walker B; other site
221988005257	D-loop; other site
221988005258	H-loop/switch region; other site
221988005259	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
221988005260	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
221988005261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
221988005262	OstA-like protein; Region: OstA; cl00844
221988005263	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
221988005264	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
221988005265	Walker A/P-loop; other site
221988005266	ATP binding site [chemical binding]; other site
221988005267	Q-loop/lid; other site
221988005268	ABC transporter signature motif; other site
221988005269	Walker B; other site
221988005270	D-loop; other site
221988005271	H-loop/switch region; other site
221988005272	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
221988005273	active site
221988005274	phosphorylation site [posttranslational modification]
221988005275	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
221988005276	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
221988005277	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
221988005278	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
221988005279	catalytic loop [active]
221988005280	iron binding site [ion binding]; other site
221988005281	chaperone protein HscA; Provisional; Region: hscA; PRK05183
221988005282	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
221988005283	nucleotide binding site [chemical binding]; other site
221988005284	putative NEF/HSP70 interaction site [polypeptide binding]; other site
221988005285	SBD interface [polypeptide binding]; other site
221988005286	co-chaperone HscB; Provisional; Region: hscB; PRK01773
221988005287	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
221988005288	HSP70 interaction site [polypeptide binding]; other site
221988005289	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
221988005290	iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011
221988005291	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
221988005292	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
221988005293	trimerization site [polypeptide binding]; other site
221988005294	active site
221988005295	Cupin domain; Region: Cupin_2; cl17218
221988005296	cysteine desulfurase; Provisional; Region: PRK14012
221988005297	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
221988005298	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
221988005299	catalytic residue [active]
221988005300	Rrf2 family protein; Region: rrf2_super; TIGR00738
221988005301	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
221988005302	putative DNA binding site [nucleotide binding]; other site
221988005303	putative Zn2+ binding site [ion binding]; other site
221988005304	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
221988005305	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
221988005306	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
221988005307	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
221988005308	active site
221988005309	dimerization interface [polypeptide binding]; other site
221988005310	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
221988005311	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
221988005312	dimer interface [polypeptide binding]; other site
221988005313	phosphorylation site [posttranslational modification]
221988005314	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
221988005315	ATP binding site [chemical binding]; other site
221988005316	Mg2+ binding site [ion binding]; other site
221988005317	G-X-G motif; other site
221988005318	Response regulator receiver domain; Region: Response_reg; pfam00072
221988005319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
221988005320	active site
221988005321	phosphorylation site [posttranslational modification]
221988005322	intermolecular recognition site; other site
221988005323	dimerization interface [polypeptide binding]; other site
221988005324	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
221988005325	putative binding surface; other site
221988005326	active site
221988005327	glutamate racemase; Provisional; Region: PRK00865
221988005328	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
221988005329	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
221988005330	generic binding surface II; other site
221988005331	ssDNA binding site; other site
221988005332	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
221988005333	ATP binding site [chemical binding]; other site
221988005334	putative Mg++ binding site [ion binding]; other site
221988005335	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
221988005336	nucleotide binding region [chemical binding]; other site
221988005337	ATP-binding site [chemical binding]; other site
221988005338	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
221988005339	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
221988005340	Zn2+ binding site [ion binding]; other site
221988005341	Mg2+ binding site [ion binding]; other site
221988005342	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
221988005343	synthetase active site [active]
221988005344	NTP binding site [chemical binding]; other site
221988005345	metal binding site [ion binding]; metal-binding site
221988005346	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
221988005347	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
221988005348	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
221988005349	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
221988005350	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
221988005351	catalytic site [active]
221988005352	G-X2-G-X-G-K; other site
221988005353	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
221988005354	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
221988005355	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
221988005356	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
221988005357	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
221988005358	Na binding site [ion binding]; other site
221988005359	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
221988005360	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
221988005361	ligand binding site [chemical binding]; other site
221988005362	NAD binding site [chemical binding]; other site
221988005363	tetramer interface [polypeptide binding]; other site
221988005364	catalytic site [active]
221988005365	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
221988005366	L-serine binding site [chemical binding]; other site
221988005367	ACT domain interface; other site
221988005368	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
221988005369	tetramer (dimer of dimers) interface [polypeptide binding]; other site
221988005370	active site
221988005371	dimer interface [polypeptide binding]; other site
221988005372	HemN family oxidoreductase; Provisional; Region: PRK05660
221988005373	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988005374	FeS/SAM binding site; other site
221988005375	HemN C-terminal domain; Region: HemN_C; pfam06969
221988005376	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
221988005377	active site
221988005378	dimerization interface [polypeptide binding]; other site
221988005379	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
221988005380	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
221988005381	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
221988005382	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
221988005383	lipoprotein signal peptidase; Provisional; Region: PRK14787
221988005384	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
221988005385	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
221988005386	active site
221988005387	HIGH motif; other site
221988005388	nucleotide binding site [chemical binding]; other site
221988005389	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
221988005390	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
221988005391	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
221988005392	active site
221988005393	KMSKS motif; other site
221988005394	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
221988005395	tRNA binding surface [nucleotide binding]; other site
221988005396	anticodon binding site; other site
221988005397	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
221988005398	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
221988005399	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
221988005400	active site
221988005401	Riboflavin kinase; Region: Flavokinase; smart00904
221988005402	EamA-like transporter family; Region: EamA; pfam00892
221988005403	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
221988005404	EamA-like transporter family; Region: EamA; pfam00892
221988005405	EamA-like transporter family; Region: EamA; pfam00892
221988005406	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
221988005407	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
221988005408	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
221988005409	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
221988005410	Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726
221988005411	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
221988005412	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988005413	motif II; other site
221988005414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
221988005415	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
221988005416	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
221988005417	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
221988005418	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
221988005419	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
221988005420	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
221988005421	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
221988005422	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
221988005423	DNA binding residues [nucleotide binding]
221988005424	DNA primase; Validated; Region: dnaG; PRK05667
221988005425	CHC2 zinc finger; Region: zf-CHC2; pfam01807
221988005426	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
221988005427	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
221988005428	active site
221988005429	metal binding site [ion binding]; metal-binding site
221988005430	interdomain interaction site; other site
221988005431	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
221988005432	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
221988005433	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
221988005434	UGMP family protein; Validated; Region: PRK09604
221988005435	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
221988005436	nucleotide binding site [chemical binding]; other site
221988005437	thymidine kinase; Provisional; Region: PRK04296
221988005438	Predicted small secreted protein [Function unknown]; Region: COG5510
221988005439	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
221988005440	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
221988005441	nucleotide binding pocket [chemical binding]; other site
221988005442	K-X-D-G motif; other site
221988005443	catalytic site [active]
221988005444	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
221988005445	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
221988005446	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
221988005447	Dimer interface [polypeptide binding]; other site
221988005448	BRCT sequence motif; other site
221988005449	cell division protein ZipA; Provisional; Region: PRK01741
221988005450	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
221988005451	FtsZ protein binding site [polypeptide binding]; other site
221988005452	putative sulfate transport protein CysZ; Validated; Region: PRK04949
221988005453	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
221988005454	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
221988005455	dimer interface [polypeptide binding]; other site
221988005456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988005457	catalytic residue [active]
221988005458	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
221988005459	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
221988005460	TadE-like protein; Region: TadE; pfam07811
221988005461	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
221988005462	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
221988005463	TPR motif; other site
221988005464	binding surface
221988005465	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
221988005466	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
221988005467	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
221988005468	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
221988005469	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
221988005470	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
221988005471	ATP binding site [chemical binding]; other site
221988005472	Walker A motif; other site
221988005473	hexamer interface [polypeptide binding]; other site
221988005474	Walker B motif; other site
221988005475	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
221988005476	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
221988005477	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
221988005478	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
221988005479	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
221988005480	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
221988005481	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
221988005482	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
221988005483	Clp amino terminal domain; Region: Clp_N; pfam02861
221988005484	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988005485	Walker A motif; other site
221988005486	ATP binding site [chemical binding]; other site
221988005487	Walker B motif; other site
221988005488	arginine finger; other site
221988005489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988005490	Walker A motif; other site
221988005491	ATP binding site [chemical binding]; other site
221988005492	Walker B motif; other site
221988005493	arginine finger; other site
221988005494	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
221988005495	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
221988005496	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
221988005497	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
221988005498	hypothetical protein; Provisional; Region: PRK10963
221988005499	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
221988005500	putative transporter; Provisional; Region: PRK10484
221988005501	Na binding site [ion binding]; other site
221988005502	Predicted membrane protein [Function unknown]; Region: COG3924
221988005503	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
221988005504	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
221988005505	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
221988005506	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
221988005507	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
221988005508	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
221988005509	carboxyltransferase (CT) interaction site; other site
221988005510	biotinylation site [posttranslational modification]; other site
221988005511	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
221988005512	Dehydroquinase class II; Region: DHquinase_II; pfam01220
221988005513	active site
221988005514	trimer interface [polypeptide binding]; other site
221988005515	dimer interface [polypeptide binding]; other site
221988005516	O-succinylbenzoate synthase; Provisional; Region: PRK05105
221988005517	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
221988005518	active site
221988005519	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
221988005520	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
221988005521	substrate binding site [chemical binding]; other site
221988005522	oxyanion hole (OAH) forming residues; other site
221988005523	trimer interface [polypeptide binding]; other site
221988005524	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
221988005525	Protein of unknown function (DUF726); Region: DUF726; pfam05277
221988005526	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
221988005527	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
221988005528	dimer interface [polypeptide binding]; other site
221988005529	tetramer interface [polypeptide binding]; other site
221988005530	PYR/PP interface [polypeptide binding]; other site
221988005531	TPP binding site [chemical binding]; other site
221988005532	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
221988005533	TPP-binding site; other site
221988005534	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
221988005535	chorismate binding enzyme; Region: Chorismate_bind; cl10555
221988005536	aminotransferase AlaT; Validated; Region: PRK09265
221988005537	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
221988005538	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988005539	homodimer interface [polypeptide binding]; other site
221988005540	catalytic residue [active]
221988005541	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
221988005542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988005543	putative substrate translocation pore; other site
221988005544	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
221988005545	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
221988005546	Putative exonuclease, RdgC; Region: RdgC; pfam04381
221988005547	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
221988005548	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
221988005549	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
221988005550	dimer interface [polypeptide binding]; other site
221988005551	active site
221988005552	metal binding site [ion binding]; metal-binding site
221988005553	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
221988005554	Transposase; Region: HTH_Tnp_1; pfam01527
221988005555	putative transposase OrfB; Reviewed; Region: PHA02517
221988005556	HTH-like domain; Region: HTH_21; pfam13276
221988005557	Integrase core domain; Region: rve; pfam00665
221988005558	Integrase core domain; Region: rve_3; pfam13683
221988005559	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
221988005560	active site
221988005561	zinc binding site [ion binding]; other site
221988005562	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
221988005563	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
221988005564	dimerization interface [polypeptide binding]; other site
221988005565	ATP binding site [chemical binding]; other site
221988005566	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
221988005567	dimerization interface [polypeptide binding]; other site
221988005568	ATP binding site [chemical binding]; other site
221988005569	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
221988005570	putative active site [active]
221988005571	catalytic triad [active]
221988005572	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
221988005573	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
221988005574	substrate binding pocket [chemical binding]; other site
221988005575	membrane-bound complex binding site; other site
221988005576	hinge residues; other site
221988005577	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
221988005578	N-acetyl-D-glucosamine binding site [chemical binding]; other site
221988005579	catalytic residue [active]
221988005580	Predicted flavoproteins [General function prediction only]; Region: COG2081
221988005581	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
221988005582	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
221988005583	cytochrome c nitrite reductase, accessory protein NrfF; Region: cyt_nit_nrfF; TIGR03147
221988005584	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
221988005585	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
221988005586	catalytic residues [active]
221988005587	central insert; other site
221988005588	cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145
221988005589	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
221988005590	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
221988005591	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
221988005592	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
221988005593	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
221988005594	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
221988005595	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
221988005596	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
221988005597	RNA binding surface [nucleotide binding]; other site
221988005598	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
221988005599	active site
221988005600	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
221988005601	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
221988005602	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
221988005603	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
221988005604	homooctamer interface [polypeptide binding]; other site
221988005605	active site
221988005606	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
221988005607	EamA-like transporter family; Region: EamA; pfam00892
221988005608	EamA-like transporter family; Region: EamA; pfam00892
221988005609	lipoyl synthase; Provisional; Region: PRK05481
221988005610	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988005611	FeS/SAM binding site; other site
221988005612	lipoate-protein ligase B; Provisional; Region: PRK14342
221988005613	hypothetical protein; Provisional; Region: PRK04998
221988005614	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
221988005615	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
221988005616	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
221988005617	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
221988005618	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
221988005619	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
221988005620	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
221988005621	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
221988005622	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
221988005623	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
221988005624	Oligomerisation domain; Region: Oligomerisation; cl00519
221988005625	cytidine deaminase; Provisional; Region: PRK09027
221988005626	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
221988005627	active site
221988005628	catalytic motif [active]
221988005629	Zn binding site [ion binding]; other site
221988005630	Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211
221988005631	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
221988005632	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
221988005633	ATP binding site [chemical binding]; other site
221988005634	Mg++ binding site [ion binding]; other site
221988005635	motif III; other site
221988005636	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
221988005637	nucleotide binding region [chemical binding]; other site
221988005638	ATP-binding site [chemical binding]; other site
221988005639	transcription termination factor Rho; Provisional; Region: rho; PRK09376
221988005640	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
221988005641	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
221988005642	RNA binding site [nucleotide binding]; other site
221988005643	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
221988005644	multimer interface [polypeptide binding]; other site
221988005645	Walker A motif; other site
221988005646	ATP binding site [chemical binding]; other site
221988005647	Walker B motif; other site
221988005648	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
221988005649	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
221988005650	UbiA prenyltransferase family; Region: UbiA; pfam01040
221988005651	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
221988005652	homodimer interaction site [polypeptide binding]; other site
221988005653	cofactor binding site; other site
221988005654	periplasmic folding chaperone; Provisional; Region: PRK10788
221988005655	SurA N-terminal domain; Region: SurA_N_3; cl07813
221988005656	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
221988005657	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
221988005658	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988005659	Walker A motif; other site
221988005660	ATP binding site [chemical binding]; other site
221988005661	Walker B motif; other site
221988005662	arginine finger; other site
221988005663	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
221988005664	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
221988005665	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
221988005666	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
221988005667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988005668	Walker A motif; other site
221988005669	ATP binding site [chemical binding]; other site
221988005670	Walker B motif; other site
221988005671	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
221988005672	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
221988005673	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
221988005674	oligomer interface [polypeptide binding]; other site
221988005675	active site residues [active]
221988005676	trigger factor; Provisional; Region: tig; PRK01490
221988005677	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
221988005678	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
221988005679	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
221988005680	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
221988005681	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
221988005682	NADP binding site [chemical binding]; other site
221988005683	homodimer interface [polypeptide binding]; other site
221988005684	substrate binding site [chemical binding]; other site
221988005685	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
221988005686	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
221988005687	Predicted metalloprotease [General function prediction only]; Region: COG2321
221988005688	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
221988005689	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
221988005690	Ligand Binding Site [chemical binding]; other site
221988005691	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
221988005692	active site
221988005693	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
221988005694	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988005695	FeS/SAM binding site; other site
221988005696	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
221988005697	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
221988005698	folate binding site [chemical binding]; other site
221988005699	NADP+ binding site [chemical binding]; other site
221988005700	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
221988005701	Uncharacterized conserved protein [Function unknown]; Region: COG2966
221988005702	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
221988005703	gamma-glutamyl kinase; Provisional; Region: PRK05429
221988005704	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
221988005705	nucleotide binding site [chemical binding]; other site
221988005706	homotetrameric interface [polypeptide binding]; other site
221988005707	putative phosphate binding site [ion binding]; other site
221988005708	putative allosteric binding site; other site
221988005709	PUA domain; Region: PUA; pfam01472
221988005710	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
221988005711	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
221988005712	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
221988005713	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
221988005714	hypothetical protein; Provisional; Region: PRK11193
221988005715	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
221988005716	putative phosphate acyltransferase; Provisional; Region: PRK05331
221988005717	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
221988005718	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
221988005719	dimer interface [polypeptide binding]; other site
221988005720	active site
221988005721	CoA binding pocket [chemical binding]; other site
221988005722	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541
221988005723	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
221988005724	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
221988005725	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
221988005726	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
221988005727	NAD(P) binding site [chemical binding]; other site
221988005728	homotetramer interface [polypeptide binding]; other site
221988005729	homodimer interface [polypeptide binding]; other site
221988005730	active site
221988005731	acyl carrier protein; Provisional; Region: acpP; PRK00982
221988005732	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
221988005733	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
221988005734	DNA replication initiation factor; Validated; Region: PRK06893
221988005735	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
221988005736	uracil-xanthine permease; Region: ncs2; TIGR00801
221988005737	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
221988005738	active site
221988005739	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
221988005740	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
221988005741	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
221988005742	metal binding site [ion binding]; metal-binding site
221988005743	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
221988005744	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
221988005745	substrate binding site [chemical binding]; other site
221988005746	glutamase interaction surface [polypeptide binding]; other site
221988005747	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
221988005748	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
221988005749	catalytic residues [active]
221988005750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
221988005751	MOSC domain; Region: MOSC; pfam03473
221988005752	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
221988005753	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
221988005754	putative active site [active]
221988005755	oxyanion strand; other site
221988005756	catalytic triad [active]
221988005757	Protein of unknown function (DUF2806); Region: DUF2806; pfam10987
221988005758	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
221988005759	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
221988005760	homodimer interface [polypeptide binding]; other site
221988005761	NAD binding pocket [chemical binding]; other site
221988005762	ATP binding pocket [chemical binding]; other site
221988005763	Mg binding site [ion binding]; other site
221988005764	active-site loop [active]
221988005765	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
221988005766	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
221988005767	active site
221988005768	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
221988005769	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988005770	active site
221988005771	motif I; other site
221988005772	motif II; other site
221988005773	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
221988005774	putative active site pocket [active]
221988005775	4-fold oligomerization interface [polypeptide binding]; other site
221988005776	metal binding residues [ion binding]; metal-binding site
221988005777	3-fold/trimer interface [polypeptide binding]; other site
221988005778	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
221988005779	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
221988005780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988005781	homodimer interface [polypeptide binding]; other site
221988005782	catalytic residue [active]
221988005783	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
221988005784	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
221988005785	NAD binding site [chemical binding]; other site
221988005786	dimerization interface [polypeptide binding]; other site
221988005787	product binding site; other site
221988005788	substrate binding site [chemical binding]; other site
221988005789	zinc binding site [ion binding]; other site
221988005790	catalytic residues [active]
221988005791	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
221988005792	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
221988005793	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
221988005794	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988005795	S-adenosylmethionine binding site [chemical binding]; other site
221988005796	aromatic amino acid transport protein; Region: araaP; TIGR00837
221988005797	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
221988005798	Predicted membrane protein [Function unknown]; Region: COG2364
221988005799	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
221988005800	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
221988005801	Nucleoside recognition; Region: Gate; pfam07670
221988005802	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
221988005803	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
221988005804	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
221988005805	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
221988005806	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
221988005807	putative metal binding site [ion binding]; other site
221988005808	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
221988005809	HSP70 interaction site [polypeptide binding]; other site
221988005810	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
221988005811	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
221988005812	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
221988005813	FMN binding site [chemical binding]; other site
221988005814	active site
221988005815	catalytic residues [active]
221988005816	substrate binding site [chemical binding]; other site
221988005817	dUMP phosphatase; Provisional; Region: PRK09449
221988005818	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988005819	motif II; other site
221988005820	hypothetical protein; Validated; Region: PRK06886
221988005821	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
221988005822	active site
221988005823	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
221988005824	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
221988005825	Sulfatase; Region: Sulfatase; cl17466
221988005826	hypothetical protein; Provisional; Region: PRK13689
221988005827	Nucleoid-associated protein [General function prediction only]; Region: COG3081
221988005828	nucleoid-associated protein NdpA; Validated; Region: PRK00378
221988005829	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
221988005830	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
221988005831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
221988005832	active site
221988005833	phosphorylation site [posttranslational modification]
221988005834	intermolecular recognition site; other site
221988005835	dimerization interface [polypeptide binding]; other site
221988005836	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
221988005837	DNA binding site [nucleotide binding]
221988005838	two-component sensor protein; Provisional; Region: cpxA; PRK09470
221988005839	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
221988005840	dimerization interface [polypeptide binding]; other site
221988005841	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
221988005842	dimer interface [polypeptide binding]; other site
221988005843	phosphorylation site [posttranslational modification]
221988005844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
221988005845	ATP binding site [chemical binding]; other site
221988005846	Mg2+ binding site [ion binding]; other site
221988005847	G-X-G motif; other site
221988005848	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
221988005849	transmembrane helices; other site
221988005850	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
221988005851	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
221988005852	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988005853	FeS/SAM binding site; other site
221988005854	TPR repeat; Region: TPR_11; pfam13414
221988005855	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
221988005856	binding surface
221988005857	TPR motif; other site
221988005858	Tetratricopeptide repeat; Region: TPR_12; pfam13424
221988005859	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
221988005860	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
221988005861	non-specific DNA binding site [nucleotide binding]; other site
221988005862	salt bridge; other site
221988005863	sequence-specific DNA binding site [nucleotide binding]; other site
221988005864	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
221988005865	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
221988005866	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
221988005867	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
221988005868	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
221988005869	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
221988005870	dimer interface [polypeptide binding]; other site
221988005871	motif 1; other site
221988005872	active site
221988005873	motif 2; other site
221988005874	motif 3; other site
221988005875	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
221988005876	anticodon binding site; other site
221988005877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
221988005878	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
221988005879	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
221988005880	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
221988005881	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
221988005882	trimer interface [polypeptide binding]; other site
221988005883	active site
221988005884	UDP-GlcNAc binding site [chemical binding]; other site
221988005885	lipid binding site [chemical binding]; lipid-binding site
221988005886	periplasmic chaperone; Provisional; Region: PRK10780
221988005887	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
221988005888	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
221988005889	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
221988005890	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
221988005891	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
221988005892	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
221988005893	Surface antigen; Region: Bac_surface_Ag; pfam01103
221988005894	zinc metallopeptidase RseP; Provisional; Region: PRK10779
221988005895	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
221988005896	active site
221988005897	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
221988005898	protein binding site [polypeptide binding]; other site
221988005899	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
221988005900	protein binding site [polypeptide binding]; other site
221988005901	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
221988005902	putative substrate binding region [chemical binding]; other site
221988005903	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
221988005904	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
221988005905	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
221988005906	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
221988005907	catalytic residue [active]
221988005908	putative FPP diphosphate  binding site; other site
221988005909	putative FPP binding hydrophobic cleft; other site
221988005910	dimer interface [polypeptide binding]; other site
221988005911	putative IPP diphosphate binding site; other site
221988005912	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
221988005913	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
221988005914	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
221988005915	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
221988005916	ribosome recycling factor; Reviewed; Region: frr; PRK00083
221988005917	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
221988005918	hinge region; other site
221988005919	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
221988005920	putative nucleotide binding site [chemical binding]; other site
221988005921	uridine monophosphate binding site [chemical binding]; other site
221988005922	homohexameric interface [polypeptide binding]; other site
221988005923	lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598
221988005924	Sulfatase; Region: Sulfatase; cl17466
221988005925	elongation factor Ts; Provisional; Region: tsf; PRK09377
221988005926	UBA/TS-N domain; Region: UBA; pfam00627
221988005927	Elongation factor TS; Region: EF_TS; pfam00889
221988005928	Elongation factor TS; Region: EF_TS; pfam00889
221988005929	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
221988005930	rRNA interaction site [nucleotide binding]; other site
221988005931	S8 interaction site; other site
221988005932	putative laminin-1 binding site; other site
221988005933	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
221988005934	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
221988005935	ligand binding site [chemical binding]; other site
221988005936	flexible hinge region; other site
221988005937	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
221988005938	putative switch regulator; other site
221988005939	non-specific DNA interactions [nucleotide binding]; other site
221988005940	DNA binding site [nucleotide binding]
221988005941	sequence specific DNA binding site [nucleotide binding]; other site
221988005942	putative cAMP binding site [chemical binding]; other site
221988005943	hypothetical protein; Provisional; Region: PRK04966
221988005944	division inhibitor protein; Provisional; Region: slmA; PRK09480
221988005945	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
221988005946	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
221988005947	trimer interface [polypeptide binding]; other site
221988005948	active site
221988005949	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
221988005950	Flavoprotein; Region: Flavoprotein; pfam02441
221988005951	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
221988005952	hypothetical protein; Reviewed; Region: PRK00024
221988005953	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
221988005954	MPN+ (JAMM) motif; other site
221988005955	Zinc-binding site [ion binding]; other site
221988005956	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
221988005957	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
221988005958	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
221988005959	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
221988005960	DNA binding site [nucleotide binding]
221988005961	catalytic residue [active]
221988005962	H2TH interface [polypeptide binding]; other site
221988005963	putative catalytic residues [active]
221988005964	turnover-facilitating residue; other site
221988005965	intercalation triad [nucleotide binding]; other site
221988005966	8OG recognition residue [nucleotide binding]; other site
221988005967	putative reading head residues; other site
221988005968	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
221988005969	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
221988005970	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
221988005971	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
221988005972	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
221988005973	Substrate binding site; other site
221988005974	Mg++ binding site; other site
221988005975	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
221988005976	active site
221988005977	substrate binding site [chemical binding]; other site
221988005978	CoA binding site [chemical binding]; other site
221988005979	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
221988005980	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
221988005981	ATP binding site [chemical binding]; other site
221988005982	Mg++ binding site [ion binding]; other site
221988005983	motif III; other site
221988005984	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
221988005985	nucleotide binding region [chemical binding]; other site
221988005986	ATP-binding site [chemical binding]; other site
221988005987	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
221988005988	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
221988005989	active site
221988005990	(T/H)XGH motif; other site
221988005991	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
221988005992	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
221988005993	Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534
221988005994	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
221988005995	dimer interface [polypeptide binding]; other site
221988005996	motif 1; other site
221988005997	active site
221988005998	motif 2; other site
221988005999	motif 3; other site
221988006000	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
221988006001	putative active site [active]
221988006002	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
221988006003	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
221988006004	Predicted membrane protein [Function unknown]; Region: COG3671
221988006005	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
221988006006	Domain of unknown function DUF20; Region: UPF0118; pfam01594
221988006007	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
221988006008	ArsC family; Region: ArsC; pfam03960
221988006009	catalytic residues [active]
221988006010	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
221988006011	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
221988006012	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
221988006013	putative active site [active]
221988006014	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
221988006015	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293
221988006016	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
221988006017	amphipathic channel; other site
221988006018	Asn-Pro-Ala signature motifs; other site
221988006019	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
221988006020	dimerization interface [polypeptide binding]; other site
221988006021	DNA binding site [nucleotide binding]
221988006022	corepressor binding sites; other site
221988006023	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
221988006024	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
221988006025	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
221988006026	active site
221988006027	dimer interface [polypeptide binding]; other site
221988006028	metal binding site [ion binding]; metal-binding site
221988006029	shikimate kinase; Reviewed; Region: aroK; PRK00131
221988006030	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
221988006031	ADP binding site [chemical binding]; other site
221988006032	magnesium binding site [ion binding]; other site
221988006033	putative shikimate binding site; other site
221988006034	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
221988006035	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
221988006036	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
221988006037	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
221988006038	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
221988006039	Transglycosylase; Region: Transgly; pfam00912
221988006040	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
221988006041	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
221988006042	fructuronate transporter; Provisional; Region: PRK10034; cl15264
221988006043	GntP family permease; Region: GntP_permease; pfam02447
221988006044	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
221988006045	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
221988006046	Metal-binding active site; metal-binding site
221988006047	putative aldolase; Validated; Region: PRK08130
221988006048	intersubunit interface [polypeptide binding]; other site
221988006049	active site
221988006050	Zn2+ binding site [ion binding]; other site
221988006051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
221988006052	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
221988006053	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
221988006054	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
221988006055	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
221988006056	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
221988006057	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
221988006058	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
221988006059	Aspartase; Region: Aspartase; cd01357
221988006060	active sites [active]
221988006061	tetramer interface [polypeptide binding]; other site
221988006062	glutathione reductase; Validated; Region: PRK06116
221988006063	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
221988006064	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
221988006065	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
221988006066	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
221988006067	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
221988006068	putative active site [active]
221988006069	glycerol kinase; Provisional; Region: glpK; PRK00047
221988006070	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
221988006071	N- and C-terminal domain interface [polypeptide binding]; other site
221988006072	active site
221988006073	MgATP binding site [chemical binding]; other site
221988006074	catalytic site [active]
221988006075	metal binding site [ion binding]; metal-binding site
221988006076	glycerol binding site [chemical binding]; other site
221988006077	homotetramer interface [polypeptide binding]; other site
221988006078	homodimer interface [polypeptide binding]; other site
221988006079	FBP binding site [chemical binding]; other site
221988006080	protein IIAGlc interface [polypeptide binding]; other site
221988006081	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
221988006082	amphipathic channel; other site
221988006083	Asn-Pro-Ala signature motifs; other site
221988006084	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
221988006085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988006086	putative substrate translocation pore; other site
221988006087	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
221988006088	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
221988006089	active site
221988006090	catalytic site [active]
221988006091	metal binding site [ion binding]; metal-binding site
221988006092	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
221988006093	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
221988006094	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
221988006095	glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378
221988006096	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
221988006097	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
221988006098	Cysteine-rich domain; Region: CCG; pfam02754
221988006099	Cysteine-rich domain; Region: CCG; pfam02754
221988006100	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
221988006101	G1 box; other site
221988006102	GTP/Mg2+ binding site [chemical binding]; other site
221988006103	Switch I region; other site
221988006104	G2 box; other site
221988006105	G3 box; other site
221988006106	Switch II region; other site
221988006107	G4 box; other site
221988006108	G5 box; other site
221988006109	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
221988006110	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
221988006111	Walker A motif; other site
221988006112	ATP binding site [chemical binding]; other site
221988006113	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
221988006114	TfoX N-terminal domain; Region: TfoX_N; pfam04993
221988006115	OsmC-like protein; Region: OsmC; pfam02566
221988006116	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988006117	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988006118	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
221988006119	dimerization interface [polypeptide binding]; other site
221988006120	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
221988006121	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
221988006122	catalytic residues [active]
221988006123	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988006124	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988006125	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
221988006126	dimerization interface [polypeptide binding]; other site
221988006127	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
221988006128	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
221988006129	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
221988006130	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
221988006131	putative active site [active]
221988006132	putative FMN binding site [chemical binding]; other site
221988006133	putative substrate binding site [chemical binding]; other site
221988006134	putative catalytic residue [active]
221988006135	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
221988006136	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
221988006137	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
221988006138	TniQ; Region: TniQ; pfam06527
221988006139	Bacterial TniB protein; Region: TniB; pfam05621
221988006140	AAA domain; Region: AAA_22; pfam13401
221988006141	Helix-turn-helix domain; Region: HTH_28; pfam13518
221988006142	Winged helix-turn helix; Region: HTH_29; pfam13551
221988006143	Integrase core domain; Region: rve; pfam00665
221988006144	Integrase core domain; Region: rve_3; cl15866
221988006145	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
221988006146	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
221988006147	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
221988006148	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
221988006149	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
221988006150	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
221988006151	TIGR01666 family membrane protein; Region: YCCS
221988006152	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
221988006153	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
221988006154	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
221988006155	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
221988006156	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
221988006157	alphaNTD homodimer interface [polypeptide binding]; other site
221988006158	alphaNTD - beta interaction site [polypeptide binding]; other site
221988006159	alphaNTD - beta' interaction site [polypeptide binding]; other site
221988006160	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
221988006161	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
221988006162	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
221988006163	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
221988006164	RNA binding surface [nucleotide binding]; other site
221988006165	30S ribosomal protein S11; Validated; Region: PRK05309
221988006166	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
221988006167	30S ribosomal protein S13; Region: bact_S13; TIGR03631
221988006168	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
221988006169	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
221988006170	SecY translocase; Region: SecY; pfam00344
221988006171	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
221988006172	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
221988006173	23S rRNA binding site [nucleotide binding]; other site
221988006174	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
221988006175	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
221988006176	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
221988006177	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
221988006178	5S rRNA interface [nucleotide binding]; other site
221988006179	L27 interface [polypeptide binding]; other site
221988006180	23S rRNA interface [nucleotide binding]; other site
221988006181	L5 interface [polypeptide binding]; other site
221988006182	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
221988006183	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
221988006184	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
221988006185	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
221988006186	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
221988006187	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
221988006188	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
221988006189	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
221988006190	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
221988006191	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
221988006192	RNA binding site [nucleotide binding]; other site
221988006193	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
221988006194	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
221988006195	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
221988006196	23S rRNA interface [nucleotide binding]; other site
221988006197	putative translocon interaction site; other site
221988006198	signal recognition particle (SRP54) interaction site; other site
221988006199	L23 interface [polypeptide binding]; other site
221988006200	trigger factor interaction site; other site
221988006201	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
221988006202	23S rRNA interface [nucleotide binding]; other site
221988006203	5S rRNA interface [nucleotide binding]; other site
221988006204	putative antibiotic binding site [chemical binding]; other site
221988006205	L25 interface [polypeptide binding]; other site
221988006206	L27 interface [polypeptide binding]; other site
221988006207	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
221988006208	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
221988006209	G-X-X-G motif; other site
221988006210	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
221988006211	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
221988006212	protein-rRNA interface [nucleotide binding]; other site
221988006213	putative translocon binding site; other site
221988006214	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
221988006215	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
221988006216	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
221988006217	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
221988006218	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
221988006219	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
221988006220	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
221988006221	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
221988006222	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
221988006223	active site
221988006224	homodimer interface [polypeptide binding]; other site
221988006225	homotetramer interface [polypeptide binding]; other site
221988006226	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
221988006227	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
221988006228	putative ion selectivity filter; other site
221988006229	putative pore gating glutamate residue; other site
221988006230	putative H+/Cl- coupling transport residue; other site
221988006231	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
221988006232	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
221988006233	FMN binding site [chemical binding]; other site
221988006234	active site
221988006235	catalytic residues [active]
221988006236	substrate binding site [chemical binding]; other site
221988006237	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
221988006238	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
221988006239	peptide binding site [polypeptide binding]; other site
221988006240	putative transporter; Provisional; Region: PRK10504
221988006241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988006242	putative substrate translocation pore; other site
221988006243	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988006244	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
221988006245	Walker A motif; other site
221988006246	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
221988006247	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
221988006248	GTP binding site; other site
221988006249	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3084
221988006250	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
221988006251	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
221988006252	catalytic residues [active]
221988006253	hinge region; other site
221988006254	alpha helical domain; other site
221988006255	hypothetical protein; Provisional; Region: PRK11027
221988006256	Uncharacterized conserved protein [Function unknown]; Region: COG1359
221988006257	prolyl-tRNA synthetase; Provisional; Region: PRK09194
221988006258	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
221988006259	dimer interface [polypeptide binding]; other site
221988006260	motif 1; other site
221988006261	active site
221988006262	motif 2; other site
221988006263	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
221988006264	putative deacylase active site [active]
221988006265	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
221988006266	active site
221988006267	motif 3; other site
221988006268	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
221988006269	anticodon binding site; other site
221988006270	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
221988006271	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
221988006272	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
221988006273	maltose regulon periplasmic protein; Provisional; Region: PRK10564
221988006274	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
221988006275	trimer interface; other site
221988006276	sugar binding site [chemical binding]; other site
221988006277	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
221988006278	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
221988006279	Walker A/P-loop; other site
221988006280	ATP binding site [chemical binding]; other site
221988006281	Q-loop/lid; other site
221988006282	ABC transporter signature motif; other site
221988006283	Walker B; other site
221988006284	D-loop; other site
221988006285	H-loop/switch region; other site
221988006286	TOBE domain; Region: TOBE_2; pfam08402
221988006287	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
221988006288	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
221988006289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988006290	dimer interface [polypeptide binding]; other site
221988006291	conserved gate region; other site
221988006292	putative PBP binding loops; other site
221988006293	ABC-ATPase subunit interface; other site
221988006294	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
221988006295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
221988006296	dimer interface [polypeptide binding]; other site
221988006297	conserved gate region; other site
221988006298	putative PBP binding loops; other site
221988006299	ABC-ATPase subunit interface; other site
221988006300	alpha-amylase; Reviewed; Region: malS; PRK09505
221988006301	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
221988006302	active site
221988006303	catalytic site [active]
221988006304	transcriptional regulator MalT; Provisional; Region: PRK04841
221988006305	AAA ATPase domain; Region: AAA_16; pfam13191
221988006306	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
221988006307	binding surface
221988006308	TPR motif; other site
221988006309	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
221988006310	DNA binding residues [nucleotide binding]
221988006311	dimerization interface [polypeptide binding]; other site
221988006312	maltodextrin phosphorylase; Provisional; Region: PRK14985
221988006313	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
221988006314	homodimer interface [polypeptide binding]; other site
221988006315	active site pocket [active]
221988006316	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
221988006317	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
221988006318	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
221988006319	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
221988006320	active site
221988006321	catalytic tetrad [active]
221988006322	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
221988006323	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
221988006324	putative ligand binding site [chemical binding]; other site
221988006325	putative NAD binding site [chemical binding]; other site
221988006326	catalytic site [active]
221988006327	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
221988006328	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
221988006329	ATP binding site [chemical binding]; other site
221988006330	putative Mg++ binding site [ion binding]; other site
221988006331	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
221988006332	nucleotide binding region [chemical binding]; other site
221988006333	ATP-binding site [chemical binding]; other site
221988006334	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
221988006335	HRDC domain; Region: HRDC; pfam00570
221988006336	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
221988006337	putative iron binding site [ion binding]; other site
221988006338	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
221988006339	diaminopimelate decarboxylase; Region: lysA; TIGR01048
221988006340	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
221988006341	active site
221988006342	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
221988006343	substrate binding site [chemical binding]; other site
221988006344	catalytic residues [active]
221988006345	dimer interface [polypeptide binding]; other site
221988006346	glutathionine S-transferase; Provisional; Region: PRK10542
221988006347	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
221988006348	C-terminal domain interface [polypeptide binding]; other site
221988006349	GSH binding site (G-site) [chemical binding]; other site
221988006350	dimer interface [polypeptide binding]; other site
221988006351	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
221988006352	dimer interface [polypeptide binding]; other site
221988006353	N-terminal domain interface [polypeptide binding]; other site
221988006354	substrate binding pocket (H-site) [chemical binding]; other site
221988006355	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
221988006356	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
221988006357	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
221988006358	HlyD family secretion protein; Region: HlyD_3; pfam13437
221988006359	ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748
221988006360	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
221988006361	MarR family; Region: MarR_2; pfam12802
221988006362	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988006363	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988006364	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
221988006365	dimerization interface [polypeptide binding]; other site
221988006366	putative effector binding pocket; other site
221988006367	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
221988006368	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
221988006369	active site
221988006370	catalytic tetrad [active]
221988006371	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
221988006372	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
221988006373	Flavin Reductases; Region: FlaRed; cl00801
221988006374	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
221988006375	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
221988006376	putative active site [active]
221988006377	putative FMN binding site [chemical binding]; other site
221988006378	putative substrate binding site [chemical binding]; other site
221988006379	putative catalytic residue [active]
221988006380	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
221988006381	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
221988006382	putative C-terminal domain interface [polypeptide binding]; other site
221988006383	putative GSH binding site (G-site) [chemical binding]; other site
221988006384	putative dimer interface [polypeptide binding]; other site
221988006385	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
221988006386	N-terminal domain interface [polypeptide binding]; other site
221988006387	dimer interface [polypeptide binding]; other site
221988006388	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
221988006389	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
221988006390	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
221988006391	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
221988006392	dinuclear metal binding motif [ion binding]; other site
221988006393	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
221988006394	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
221988006395	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988006396	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
221988006397	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988006398	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
221988006399	Nuclease-related domain; Region: NERD; pfam08378
221988006400	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
221988006401	AAA domain; Region: AAA_14; pfam13173
221988006402	Protein of unknown function, DUF606; Region: DUF606; pfam04657
221988006403	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
221988006404	dimer interface [polypeptide binding]; other site
221988006405	FMN binding site [chemical binding]; other site
221988006406	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988006407	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988006408	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
221988006409	putative effector binding pocket; other site
221988006410	dimerization interface [polypeptide binding]; other site
221988006411	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
221988006412	active site
221988006413	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
221988006414	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
221988006415	metal binding site [ion binding]; metal-binding site
221988006416	dimer interface [polypeptide binding]; other site
221988006417	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
221988006418	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
221988006419	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
221988006420	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
221988006421	Putative esterase; Region: Esterase; pfam00756
221988006422	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
221988006423	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
221988006424	Uncharacterized conserved protein [Function unknown]; Region: COG4925
221988006425	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
221988006426	trimer interface [polypeptide binding]; other site
221988006427	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
221988006428	active site
221988006429	substrate binding site [chemical binding]; other site
221988006430	CoA binding site [chemical binding]; other site
221988006431	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
221988006432	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988006433	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988006434	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
221988006435	dimerization interface [polypeptide binding]; other site
221988006436	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
221988006437	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
221988006438	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988006439	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988006440	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
221988006441	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
221988006442	NAD(P) binding site [chemical binding]; other site
221988006443	catalytic residues [active]
221988006444	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988006445	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988006446	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
221988006447	putative effector binding pocket; other site
221988006448	dimerization interface [polypeptide binding]; other site
221988006449	Pirin-related protein [General function prediction only]; Region: COG1741
221988006450	Pirin; Region: Pirin; pfam02678
221988006451	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
221988006452	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
221988006453	TrkA-N domain; Region: TrkA_N; pfam02254
221988006454	Predicted membrane protein [Function unknown]; Region: COG2259
221988006455	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
221988006456	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
221988006457	YCII-related domain; Region: YCII; cl00999
221988006458	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988006459	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988006460	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
221988006461	putative effector binding pocket; other site
221988006462	dimerization interface [polypeptide binding]; other site
221988006463	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
221988006464	NAD(P) binding site [chemical binding]; other site
221988006465	active site
221988006466	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
221988006467	classical (c) SDRs; Region: SDR_c; cd05233
221988006468	NAD(P) binding site [chemical binding]; other site
221988006469	active site
221988006470	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
221988006471	MarR family; Region: MarR_2; pfam12802
221988006472	ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748
221988006473	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
221988006474	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
221988006475	putative FMN binding site [chemical binding]; other site
221988006476	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988006477	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988006478	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
221988006479	dimerization interface [polypeptide binding]; other site
221988006480	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988006481	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988006482	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
221988006483	putative effector binding pocket; other site
221988006484	putative dimerization interface [polypeptide binding]; other site
221988006485	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
221988006486	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
221988006487	putative active site [active]
221988006488	putative FMN binding site [chemical binding]; other site
221988006489	putative substrate binding site [chemical binding]; other site
221988006490	putative catalytic residue [active]
221988006491	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
221988006492	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
221988006493	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
221988006494	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
221988006495	catalytic residues [active]
221988006496	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
221988006497	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
221988006498	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
221988006499	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
221988006500	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
221988006501	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
221988006502	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
221988006503	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012
221988006504	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
221988006505	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
221988006506	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
221988006507	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
221988006508	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
221988006509	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
221988006510	NAD(P) binding site [chemical binding]; other site
221988006511	active site
221988006512	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
221988006513	HsdM N-terminal domain; Region: HsdM_N; pfam12161
221988006514	Methyltransferase domain; Region: Methyltransf_26; pfam13659
221988006515	Fic/DOC family; Region: Fic; pfam02661
221988006516	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
221988006517	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
221988006518	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
221988006519	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
221988006520	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
221988006521	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
221988006522	ATP binding site [chemical binding]; other site
221988006523	putative Mg++ binding site [ion binding]; other site
221988006524	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
221988006525	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
221988006526	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
221988006527	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988006528	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
221988006529	substrate binding site [chemical binding]; other site
221988006530	daunorubicin C-13 ketoreductase (KR), classical (c)-like SDRs; Region: DR_C-13_KR_SDR_c_like; cd08951
221988006531	short chain dehydrogenase; Provisional; Region: PRK06197
221988006532	putative NAD(P) binding site [chemical binding]; other site
221988006533	active site
221988006534	Transcriptional regulator [Transcription]; Region: LysR; COG0583
221988006535	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
221988006536	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
221988006537	dimerization interface [polypeptide binding]; other site
221988006538	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
221988006539	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
221988006540	putative metal binding site [ion binding]; other site
221988006541	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
221988006542	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
221988006543	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
221988006544	active site
221988006545	P-loop; other site
221988006546	phosphorylation site [posttranslational modification]
221988006547	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
221988006548	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
221988006549	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
221988006550	putative substrate binding site [chemical binding]; other site
221988006551	putative ATP binding site [chemical binding]; other site
221988006552	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK13779
221988006553	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
221988006554	active site
221988006555	phosphorylation site [posttranslational modification]
221988006556	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
221988006557	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
221988006558	dimerization domain swap beta strand [polypeptide binding]; other site
221988006559	regulatory protein interface [polypeptide binding]; other site
221988006560	active site
221988006561	regulatory phosphorylation site [posttranslational modification]; other site
221988006562	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
221988006563	dimerization domain swap beta strand [polypeptide binding]; other site
221988006564	regulatory protein interface [polypeptide binding]; other site
221988006565	active site
221988006566	regulatory phosphorylation site [posttranslational modification]; other site
221988006567	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
221988006568	active site residue [active]
221988006569	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
221988006570	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
221988006571	Rhomboid family; Region: Rhomboid; pfam01694
221988006572	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
221988006573	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
221988006574	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
221988006575	elongation factor Tu; Reviewed; Region: PRK00049
221988006576	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
221988006577	G1 box; other site
221988006578	GEF interaction site [polypeptide binding]; other site
221988006579	GTP/Mg2+ binding site [chemical binding]; other site
221988006580	Switch I region; other site
221988006581	G2 box; other site
221988006582	G3 box; other site
221988006583	Switch II region; other site
221988006584	G4 box; other site
221988006585	G5 box; other site
221988006586	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
221988006587	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
221988006588	Antibiotic Binding Site [chemical binding]; other site
221988006589	pantothenate kinase; Provisional; Region: PRK05439
221988006590	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
221988006591	ATP-binding site [chemical binding]; other site
221988006592	CoA-binding site [chemical binding]; other site
221988006593	Mg2+-binding site [ion binding]; other site
221988006594	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
221988006595	homotrimer interaction site [polypeptide binding]; other site
221988006596	putative active site [active]
221988006597	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
221988006598	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
221988006599	putative catalytic cysteine [active]
221988006600	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
221988006601	putative active site [active]
221988006602	metal binding site [ion binding]; metal-binding site
221988006603	Patatin-like phospholipase; Region: Patatin; pfam01734
221988006604	active site
221988006605	nucleophile elbow; other site
221988006606	hypothetical protein; Provisional; Region: PRK07101
221988006607	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
221988006608	substrate-cofactor binding pocket; other site
221988006609	para-aminobenzoate synthase component I; Validated; Region: PRK07093
221988006610	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
221988006611	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
221988006612	Glutamine amidotransferase class-I; Region: GATase; pfam00117
221988006613	glutamine binding [chemical binding]; other site
221988006614	catalytic triad [active]
221988006615	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
221988006616	TrkA-N domain; Region: TrkA_N; pfam02254
221988006617	TrkA-C domain; Region: TrkA_C; pfam02080
221988006618	TrkA-N domain; Region: TrkA_N; pfam02254
221988006619	TrkA-C domain; Region: TrkA_C; pfam02080
221988006620	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
221988006621	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
221988006622	RNase E inhibitor protein; Provisional; Region: PRK11191
221988006623	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
221988006624	Protein of unknown function (DUF541); Region: SIMPL; cl01077
221988006625	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
221988006626	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
221988006627	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
221988006628	active site
221988006629	catalytic residues [active]
221988006630	metal binding site [ion binding]; metal-binding site
221988006631	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
221988006632	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
221988006633	putative active site [active]
221988006634	substrate binding site [chemical binding]; other site
221988006635	putative cosubstrate binding site; other site
221988006636	catalytic site [active]
221988006637	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
221988006638	substrate binding site [chemical binding]; other site
221988006639	16S rRNA methyltransferase B; Provisional; Region: PRK10901
221988006640	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
221988006641	putative RNA binding site [nucleotide binding]; other site
221988006642	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988006643	S-adenosylmethionine binding site [chemical binding]; other site
221988006644	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
221988006645	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
221988006646	active site
221988006647	dimer interface [polypeptide binding]; other site
221988006648	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
221988006649	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
221988006650	active site
221988006651	trimer interface [polypeptide binding]; other site
221988006652	allosteric site; other site
221988006653	active site lid [active]
221988006654	hexamer (dimer of trimers) interface [polypeptide binding]; other site
221988006655	Domain of unknown function (DUF386); Region: DUF386; pfam04074
221988006656	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
221988006657	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
221988006658	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
221988006659	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
221988006660	RNA binding site [nucleotide binding]; other site
221988006661	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
221988006662	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
221988006663	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
221988006664	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
221988006665	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
221988006666	serine acetyltransferase; Provisional; Region: cysE; PRK11132
221988006667	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
221988006668	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
221988006669	trimer interface [polypeptide binding]; other site
221988006670	active site
221988006671	substrate binding site [chemical binding]; other site
221988006672	CoA binding site [chemical binding]; other site
221988006673	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
221988006674	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
221988006675	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
221988006676	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
221988006677	SecA binding site; other site
221988006678	Preprotein binding site; other site
221988006679	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
221988006680	active site residue [active]
221988006681	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
221988006682	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
221988006683	threonine dehydratase; Reviewed; Region: PRK09224
221988006684	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
221988006685	tetramer interface [polypeptide binding]; other site
221988006686	pyridoxal 5'-phosphate binding site [chemical binding]; other site
221988006687	catalytic residue [active]
221988006688	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
221988006689	putative Ile/Val binding site [chemical binding]; other site
221988006690	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
221988006691	putative Ile/Val binding site [chemical binding]; other site
221988006692	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
221988006693	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
221988006694	dimer interface [polypeptide binding]; other site
221988006695	substrate binding site [chemical binding]; other site
221988006696	metal binding sites [ion binding]; metal-binding site
221988006697	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
221988006698	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
221988006699	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
221988006700	PYR/PP interface [polypeptide binding]; other site
221988006701	dimer interface [polypeptide binding]; other site
221988006702	TPP binding site [chemical binding]; other site
221988006703	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
221988006704	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
221988006705	TPP-binding site [chemical binding]; other site
221988006706	dimer interface [polypeptide binding]; other site
221988006707	putative hydrolase; Provisional; Region: PRK10976
221988006708	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988006709	active site
221988006710	motif I; other site
221988006711	motif II; other site
221988006712	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988006713	chromosome condensation membrane protein; Provisional; Region: PRK14196
221988006714	Uncharacterized conserved protein [Function unknown]; Region: COG2938
221988006715	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
221988006716	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
221988006717	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
221988006718	DNA binding residues [nucleotide binding]
221988006719	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
221988006720	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
221988006721	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
221988006722	anti-sigma E factor; Provisional; Region: rseB; PRK09455
221988006723	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
221988006724	Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086
221988006725	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
221988006726	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
221988006727	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
221988006728	DNA utilization protein GntX; Provisional; Region: PRK11595
221988006729	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
221988006730	active site
221988006731	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988006732	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
221988006733	active site
221988006734	motif I; other site
221988006735	motif II; other site
221988006736	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
221988006737	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
221988006738	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
221988006739	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
221988006740	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
221988006741	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
221988006742	ATP-grasp domain; Region: ATP-grasp_4; cl17255
221988006743	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
221988006744	IMP binding site; other site
221988006745	dimer interface [polypeptide binding]; other site
221988006746	interdomain contacts; other site
221988006747	partial ornithine binding site; other site
221988006748	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
221988006749	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
221988006750	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
221988006751	catalytic site [active]
221988006752	subunit interface [polypeptide binding]; other site
221988006753	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
221988006754	hypothetical protein; Validated; Region: PRK05445
221988006755	Tannase and feruloyl esterase; Region: Tannase; pfam07519
221988006756	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
221988006757	recombination regulator RecX; Reviewed; Region: recX; PRK00117
221988006758	recombinase A; Provisional; Region: recA; PRK09354
221988006759	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
221988006760	hexamer interface [polypeptide binding]; other site
221988006761	Walker A motif; other site
221988006762	ATP binding site [chemical binding]; other site
221988006763	Walker B motif; other site
221988006764	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
221988006765	MutS domain I; Region: MutS_I; pfam01624
221988006766	MutS domain II; Region: MutS_II; pfam05188
221988006767	MutS domain III; Region: MutS_III; pfam05192
221988006768	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
221988006769	Walker A/P-loop; other site
221988006770	ATP binding site [chemical binding]; other site
221988006771	Q-loop/lid; other site
221988006772	ABC transporter signature motif; other site
221988006773	Walker B; other site
221988006774	D-loop; other site
221988006775	H-loop/switch region; other site
221988006776	Predicted membrane protein [Function unknown]; Region: COG4125
221988006777	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
221988006778	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
221988006779	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
221988006780	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
221988006781	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
221988006782	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
221988006783	FeS/SAM binding site; other site
221988006784	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
221988006785	active site residue [active]
221988006786	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
221988006787	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
221988006788	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
221988006789	ATP binding site [chemical binding]; other site
221988006790	Mg2+ binding site [ion binding]; other site
221988006791	G-X-G motif; other site
221988006792	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
221988006793	anchoring element; other site
221988006794	dimer interface [polypeptide binding]; other site
221988006795	ATP binding site [chemical binding]; other site
221988006796	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
221988006797	active site
221988006798	putative metal-binding site [ion binding]; other site
221988006799	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
221988006800	FMN-binding protein MioC; Provisional; Region: PRK09004
221988006801	Lysine efflux permease [General function prediction only]; Region: COG1279
221988006802	Protein of unknown function (DUF904); Region: DUF904; pfam06005
221988006803	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
221988006804	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
221988006805	putative active site [active]
221988006806	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
221988006807	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
221988006808	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
221988006809	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
221988006810	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
221988006811	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
221988006812	putative active site [active]
221988006813	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
221988006814	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
221988006815	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
221988006816	putative active site [active]
221988006817	conserved hypothetical protein; Region: TIGR00743
221988006818	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
221988006819	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
221988006820	dimerization interface [polypeptide binding]; other site
221988006821	domain crossover interface; other site
221988006822	redox-dependent activation switch; other site
221988006823	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
221988006824	RNA binding surface [nucleotide binding]; other site
221988006825	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
221988006826	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
221988006827	acyl-activating enzyme (AAE) consensus motif; other site
221988006828	putative AMP binding site [chemical binding]; other site
221988006829	putative active site [active]
221988006830	putative CoA binding site [chemical binding]; other site
221988006831	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
221988006832	Peptidase family M23; Region: Peptidase_M23; pfam01551
221988006833	Predicted membrane protein [Function unknown]; Region: COG1238
221988006834	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
221988006835	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
221988006836	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
221988006837	Permutation of conserved domain; other site
221988006838	active site
221988006839	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
221988006840	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
221988006841	homotrimer interaction site [polypeptide binding]; other site
221988006842	zinc binding site [ion binding]; other site
221988006843	CDP-binding sites; other site
221988006844	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
221988006845	substrate binding site; other site
221988006846	dimer interface; other site
221988006847	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
221988006848	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
221988006849	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
221988006850	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
221988006851	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
221988006852	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
221988006853	4Fe-4S binding domain; Region: Fer4_5; pfam12801
221988006854	4Fe-4S binding domain; Region: Fer4_6; pfam12837
221988006855	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
221988006856	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
221988006857	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
221988006858	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
221988006859	[4Fe-4S] binding site [ion binding]; other site
221988006860	molybdopterin cofactor binding site; other site
221988006861	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
221988006862	molybdopterin cofactor binding site; other site
221988006863	NapD protein; Region: NapD; pfam03927
221988006864	ferredoxin-type protein NapF; Region: napF; TIGR00402
221988006865	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
221988006866	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
221988006867	4Fe-4S binding domain; Region: Fer4; pfam00037
221988006868	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
221988006869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988006870	putative substrate translocation pore; other site
221988006871	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
221988006872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
221988006873	active site
221988006874	phosphorylation site [posttranslational modification]
221988006875	intermolecular recognition site; other site
221988006876	dimerization interface [polypeptide binding]; other site
221988006877	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
221988006878	DNA binding residues [nucleotide binding]
221988006879	dimerization interface [polypeptide binding]; other site
221988006880	sensory histidine kinase UhpB; Provisional; Region: PRK11644
221988006881	MASE1; Region: MASE1; pfam05231
221988006882	Histidine kinase; Region: HisKA_3; pfam07730
221988006883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
221988006884	ATP binding site [chemical binding]; other site
221988006885	Mg2+ binding site [ion binding]; other site
221988006886	G-X-G motif; other site
221988006887	regulatory protein UhpC; Provisional; Region: PRK11663
221988006888	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988006889	putative substrate translocation pore; other site
221988006890	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
221988006891	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
221988006892	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
221988006893	dimerization interface [polypeptide binding]; other site
221988006894	Histidine kinase; Region: HisKA_3; pfam07730
221988006895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
221988006896	ATP binding site [chemical binding]; other site
221988006897	Mg2+ binding site [ion binding]; other site
221988006898	G-X-G motif; other site
221988006899	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
221988006900	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
221988006901	Coenzyme A binding pocket [chemical binding]; other site
221988006902	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
221988006903	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
221988006904	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
221988006905	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
221988006906	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
221988006907	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
221988006908	active site
221988006909	substrate-binding site [chemical binding]; other site
221988006910	metal-binding site [ion binding]
221988006911	ATP binding site [chemical binding]; other site
221988006912	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
221988006913	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
221988006914	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
221988006915	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
221988006916	putative active site [active]
221988006917	putative FMN binding site [chemical binding]; other site
221988006918	putative substrate binding site [chemical binding]; other site
221988006919	putative catalytic residue [active]
221988006920	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
221988006921	Transposase; Region: HTH_Tnp_1; pfam01527
221988006922	putative transposase OrfB; Reviewed; Region: PHA02517
221988006923	HTH-like domain; Region: HTH_21; pfam13276
221988006924	Integrase core domain; Region: rve; pfam00665
221988006925	Integrase core domain; Region: rve_3; pfam13683
221988006926	TfoX N-terminal domain; Region: TfoX_N; pfam04993
221988006927	TfoX C-terminal domain; Region: TfoX_C; pfam04994
221988006928	DNA repair protein RadA; Region: sms; TIGR00416
221988006929	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
221988006930	Walker A motif/ATP binding site; other site
221988006931	ATP binding site [chemical binding]; other site
221988006932	Walker B motif; other site
221988006933	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
221988006934	Uncharacterized conserved protein [Function unknown]; Region: COG3025
221988006935	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
221988006936	putative active site [active]
221988006937	putative metal binding residues [ion binding]; other site
221988006938	signature motif; other site
221988006939	putative triphosphate binding site [ion binding]; other site
221988006940	TIGR00153 family protein; Region: TIGR00153
221988006941	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
221988006942	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
221988006943	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
221988006944	Bacterial SH3 domain homologues; Region: SH3b; smart00287
221988006945	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
221988006946	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
221988006947	active site
221988006948	NTP binding site [chemical binding]; other site
221988006949	metal binding triad [ion binding]; metal-binding site
221988006950	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
221988006951	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
221988006952	Zn2+ binding site [ion binding]; other site
221988006953	Mg2+ binding site [ion binding]; other site
221988006954	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
221988006955	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
221988006956	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
221988006957	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
221988006958	shikimate binding site; other site
221988006959	NAD(P) binding site [chemical binding]; other site
221988006960	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
221988006961	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
221988006962	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
221988006963	Uncharacterized integral membrane protein [Function unknown]; Region: COG5413
221988006964	uridine phosphorylase; Provisional; Region: PRK11178
221988006965	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
221988006966	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
221988006967	NodB motif; other site
221988006968	putative active site [active]
221988006969	putative catalytic site [active]
221988006970	Zn binding site [ion binding]; other site
221988006971	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
221988006972	Peptidase family M23; Region: Peptidase_M23; pfam01551
221988006973	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
221988006974	catalytic core [active]
221988006975	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
221988006976	transcriptional activator RhaS; Provisional; Region: PRK13503
221988006977	Cupin domain; Region: Cupin_2; cl17218
221988006978	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988006979	transcriptional activator RhaR; Provisional; Region: PRK13501
221988006980	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
221988006981	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988006982	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
221988006983	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
221988006984	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
221988006985	dimer interface [polypeptide binding]; other site
221988006986	active site
221988006987	metal binding site [ion binding]; metal-binding site
221988006988	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
221988006989	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
221988006990	rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634
221988006991	intersubunit interface [polypeptide binding]; other site
221988006992	active site
221988006993	Zn2+ binding site [ion binding]; other site
221988006994	L-rhamnose isomerase; Provisional; Region: PRK01076
221988006995	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
221988006996	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
221988006997	N- and C-terminal domain interface [polypeptide binding]; other site
221988006998	active site
221988006999	putative catalytic site [active]
221988007000	metal binding site [ion binding]; metal-binding site
221988007001	ATP binding site [chemical binding]; other site
221988007002	rhamnulokinase; Provisional; Region: rhaB; PRK10640
221988007003	carbohydrate binding site [chemical binding]; other site
221988007004	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
221988007005	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
221988007006	substrate binding site [chemical binding]; other site
221988007007	hexamer interface [polypeptide binding]; other site
221988007008	metal binding site [ion binding]; metal-binding site
221988007009	phosphoglycolate phosphatase; Provisional; Region: PRK13222
221988007010	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
221988007011	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988007012	motif II; other site
221988007013	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
221988007014	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
221988007015	active site
221988007016	HIGH motif; other site
221988007017	dimer interface [polypeptide binding]; other site
221988007018	KMSKS motif; other site
221988007019	Mechanosensitive ion channel; Region: MS_channel; pfam00924
221988007020	ferredoxin-type protein NapF; Region: napF; TIGR00402
221988007021	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
221988007022	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
221988007023	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
221988007024	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
221988007025	selenocysteine synthase; Provisional; Region: PRK04311
221988007026	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
221988007027	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
221988007028	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
221988007029	catalytic residue [active]
221988007030	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
221988007031	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
221988007032	G1 box; other site
221988007033	putative GEF interaction site [polypeptide binding]; other site
221988007034	GTP/Mg2+ binding site [chemical binding]; other site
221988007035	Switch I region; other site
221988007036	G2 box; other site
221988007037	G3 box; other site
221988007038	Switch II region; other site
221988007039	G4 box; other site
221988007040	G5 box; other site
221988007041	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
221988007042	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
221988007043	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
221988007044	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
221988007045	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
221988007046	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
221988007047	nudix motif; other site
221988007048	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
221988007049	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
221988007050	probable active site [active]
221988007051	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
221988007052	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988007053	active site
221988007054	motif I; other site
221988007055	motif II; other site
221988007056	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
221988007057	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
221988007058	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
221988007059	gamma subunit interface [polypeptide binding]; other site
221988007060	epsilon subunit interface [polypeptide binding]; other site
221988007061	LBP interface [polypeptide binding]; other site
221988007062	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
221988007063	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
221988007064	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
221988007065	alpha subunit interaction interface [polypeptide binding]; other site
221988007066	Walker A motif; other site
221988007067	ATP binding site [chemical binding]; other site
221988007068	Walker B motif; other site
221988007069	inhibitor binding site; inhibition site
221988007070	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
221988007071	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
221988007072	core domain interface [polypeptide binding]; other site
221988007073	delta subunit interface [polypeptide binding]; other site
221988007074	epsilon subunit interface [polypeptide binding]; other site
221988007075	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
221988007076	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
221988007077	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
221988007078	beta subunit interaction interface [polypeptide binding]; other site
221988007079	Walker A motif; other site
221988007080	ATP binding site [chemical binding]; other site
221988007081	Walker B motif; other site
221988007082	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
221988007083	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
221988007084	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
221988007085	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
221988007086	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
221988007087	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
221988007088	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
221988007089	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
221988007090	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
221988007091	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
221988007092	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
221988007093	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
221988007094	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
221988007095	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
221988007096	transaldolase-like protein; Provisional; Region: PTZ00411
221988007097	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
221988007098	active site
221988007099	dimer interface [polypeptide binding]; other site
221988007100	catalytic residue [active]
221988007101	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
221988007102	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
221988007103	OstA-like protein; Region: OstA; pfam03968
221988007104	Organic solvent tolerance protein; Region: OstA_C; pfam04453
221988007105	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
221988007106	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
221988007107	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
221988007108	putative substrate-binding site; other site
221988007109	nickel binding site [ion binding]; other site
221988007110	hydrogenase 2 large subunit; Provisional; Region: PRK10467
221988007111	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
221988007112	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
221988007113	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
221988007114	4Fe-4S binding domain; Region: Fer4_6; pfam12837
221988007115	hydrogenase 2 small subunit; Provisional; Region: PRK10468
221988007116	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
221988007117	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
221988007118	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
221988007119	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
221988007120	S-adenosylmethionine binding site [chemical binding]; other site
221988007121	Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445
221988007122	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
221988007123	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
221988007124	substrate binding site [chemical binding]; other site
221988007125	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
221988007126	substrate binding site [chemical binding]; other site
221988007127	ligand binding site [chemical binding]; other site
221988007128	isocitrate dehydrogenase; Validated; Region: PRK07362
221988007129	isocitrate dehydrogenase; Reviewed; Region: PRK07006
221988007130	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
221988007131	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
221988007132	dimer interface [polypeptide binding]; other site
221988007133	active site
221988007134	citrylCoA binding site [chemical binding]; other site
221988007135	NADH binding [chemical binding]; other site
221988007136	cationic pore residues; other site
221988007137	oxalacetate/citrate binding site [chemical binding]; other site
221988007138	coenzyme A binding site [chemical binding]; other site
221988007139	catalytic triad [active]
221988007140	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
221988007141	xylulokinase; Provisional; Region: PRK15027
221988007142	N- and C-terminal domain interface [polypeptide binding]; other site
221988007143	active site
221988007144	MgATP binding site [chemical binding]; other site
221988007145	catalytic site [active]
221988007146	metal binding site [ion binding]; metal-binding site
221988007147	xylulose binding site [chemical binding]; other site
221988007148	homodimer interface [polypeptide binding]; other site
221988007149	xylose isomerase; Provisional; Region: PRK05474
221988007150	xylose isomerase; Region: xylose_isom_A; TIGR02630
221988007151	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
221988007152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
221988007153	putative substrate translocation pore; other site
221988007154	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
221988007155	putative dimerization interface [polypeptide binding]; other site
221988007156	Transcriptional regulators [Transcription]; Region: PurR; COG1609
221988007157	putative ligand binding site [chemical binding]; other site
221988007158	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
221988007159	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
221988007160	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
221988007161	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
221988007162	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
221988007163	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
221988007164	active pocket/dimerization site; other site
221988007165	active site
221988007166	phosphorylation site [posttranslational modification]
221988007167	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
221988007168	active site
221988007169	phosphorylation site [posttranslational modification]
221988007170	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
221988007171	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
221988007172	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
221988007173	Na2 binding site [ion binding]; other site
221988007174	putative substrate binding site 1 [chemical binding]; other site
221988007175	Na binding site 1 [ion binding]; other site
221988007176	putative substrate binding site 2 [chemical binding]; other site