-- dump date   	20140619_135539
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
394221000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
394221000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
394221000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221000004	Walker A motif; other site
394221000005	ATP binding site [chemical binding]; other site
394221000006	Walker B motif; other site
394221000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
394221000008	DnaA box-binding interface [nucleotide binding]; other site
394221000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
394221000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
394221000011	putative DNA binding surface [nucleotide binding]; other site
394221000012	dimer interface [polypeptide binding]; other site
394221000013	beta-clamp/clamp loader binding surface; other site
394221000014	beta-clamp/translesion DNA polymerase binding surface; other site
394221000015	recombination protein F; Reviewed; Region: recF; PRK00064
394221000016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221000017	Walker A/P-loop; other site
394221000018	ATP binding site [chemical binding]; other site
394221000019	Q-loop/lid; other site
394221000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221000021	ABC transporter signature motif; other site
394221000022	Walker B; other site
394221000023	D-loop; other site
394221000024	H-loop/switch region; other site
394221000025	CAAX protease self-immunity; Region: Abi; pfam02517
394221000026	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221000027	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221000028	Uncharacterized conserved protein [Function unknown]; Region: COG2308
394221000029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
394221000030	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
394221000031	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
394221000032	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
394221000033	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
394221000034	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
394221000035	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
394221000036	active site
394221000037	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
394221000038	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
394221000039	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
394221000040	Ligand binding site; other site
394221000041	Putative Catalytic site; other site
394221000042	DXD motif; other site
394221000043	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
394221000044	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
394221000045	Uncharacterized conserved protein [Function unknown]; Region: COG0398
394221000046	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
394221000047	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
394221000048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221000049	ATP binding site [chemical binding]; other site
394221000050	Mg2+ binding site [ion binding]; other site
394221000051	G-X-G motif; other site
394221000052	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
394221000053	anchoring element; other site
394221000054	dimer interface [polypeptide binding]; other site
394221000055	ATP binding site [chemical binding]; other site
394221000056	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
394221000057	active site
394221000058	putative metal-binding site [ion binding]; other site
394221000059	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
394221000060	DNA polymerase I; Provisional; Region: PRK05755
394221000061	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
394221000062	active site
394221000063	metal binding site 1 [ion binding]; metal-binding site
394221000064	putative 5' ssDNA interaction site; other site
394221000065	metal binding site 3; metal-binding site
394221000066	metal binding site 2 [ion binding]; metal-binding site
394221000067	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
394221000068	putative DNA binding site [nucleotide binding]; other site
394221000069	putative metal binding site [ion binding]; other site
394221000070	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
394221000071	active site
394221000072	catalytic site [active]
394221000073	substrate binding site [chemical binding]; other site
394221000074	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
394221000075	active site
394221000076	DNA binding site [nucleotide binding]
394221000077	catalytic site [active]
394221000078	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
394221000079	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221000080	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
394221000081	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
394221000082	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
394221000083	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
394221000084	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
394221000085	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
394221000086	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221000087	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
394221000088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221000089	NAD(P) binding site [chemical binding]; other site
394221000090	active site
394221000091	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
394221000092	catalytic nucleophile [active]
394221000093	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
394221000094	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
394221000095	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
394221000096	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
394221000097	FeS/SAM binding site; other site
394221000098	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
394221000099	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
394221000100	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
394221000101	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
394221000102	dimer interface [polypeptide binding]; other site
394221000103	putative CheW interface [polypeptide binding]; other site
394221000104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221000105	S-adenosylmethionine binding site [chemical binding]; other site
394221000106	Creatinine amidohydrolase; Region: Creatininase; pfam02633
394221000107	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
394221000108	iron-sulfur cluster [ion binding]; other site
394221000109	[2Fe-2S] cluster binding site [ion binding]; other site
394221000110	YciI-like protein; Reviewed; Region: PRK12863
394221000111	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
394221000112	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
394221000113	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
394221000114	UGMP family protein; Validated; Region: PRK09604
394221000115	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
394221000116	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
394221000117	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
394221000118	domain interfaces; other site
394221000119	active site
394221000120	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
394221000121	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
394221000122	active site
394221000123	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
394221000124	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
394221000125	HemY protein N-terminus; Region: HemY_N; pfam07219
394221000126	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
394221000127	AAA domain; Region: AAA_18; pfam13238
394221000128	ATP-binding site [chemical binding]; other site
394221000129	Sugar specificity; other site
394221000130	Pyrimidine base specificity; other site
394221000131	putative S-transferase; Provisional; Region: PRK11752
394221000132	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
394221000133	C-terminal domain interface [polypeptide binding]; other site
394221000134	GSH binding site (G-site) [chemical binding]; other site
394221000135	dimer interface [polypeptide binding]; other site
394221000136	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
394221000137	dimer interface [polypeptide binding]; other site
394221000138	N-terminal domain interface [polypeptide binding]; other site
394221000139	active site
394221000140	choice-of-anchor B domain; Region: choice_anch_B; TIGR04312
394221000141	Domain of unknown function (DUF305); Region: DUF305; pfam03713
394221000142	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
394221000143	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
394221000144	heme binding site [chemical binding]; other site
394221000145	ferroxidase pore; other site
394221000146	ferroxidase diiron center [ion binding]; other site
394221000147	Uncharacterized conserved protein [Function unknown]; Region: COG2013
394221000148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
394221000149	phosphorylation site [posttranslational modification]
394221000150	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
394221000151	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
394221000152	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
394221000153	homodimer interface [polypeptide binding]; other site
394221000154	NADP binding site [chemical binding]; other site
394221000155	substrate binding site [chemical binding]; other site
394221000156	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
394221000157	YGGT family; Region: YGGT; pfam02325
394221000158	Response regulator receiver domain; Region: Response_reg; pfam00072
394221000159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221000160	active site
394221000161	phosphorylation site [posttranslational modification]
394221000162	intermolecular recognition site; other site
394221000163	dimerization interface [polypeptide binding]; other site
394221000164	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221000165	non-specific DNA binding site [nucleotide binding]; other site
394221000166	salt bridge; other site
394221000167	sequence-specific DNA binding site [nucleotide binding]; other site
394221000168	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
394221000169	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
394221000170	aromatic arch; other site
394221000171	DCoH dimer interaction site [polypeptide binding]; other site
394221000172	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
394221000173	DCoH tetramer interaction site [polypeptide binding]; other site
394221000174	substrate binding site [chemical binding]; other site
394221000175	biotin synthase; Region: bioB; TIGR00433
394221000176	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
394221000177	FeS/SAM binding site; other site
394221000178	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
394221000179	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
394221000180	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
394221000181	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
394221000182	active site triad [active]
394221000183	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
394221000184	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
394221000185	SnoaL-like domain; Region: SnoaL_2; pfam12680
394221000186	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221000187	dimerization interface [polypeptide binding]; other site
394221000188	putative DNA binding site [nucleotide binding]; other site
394221000189	putative Zn2+ binding site [ion binding]; other site
394221000190	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
394221000191	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221000192	Walker A/P-loop; other site
394221000193	ATP binding site [chemical binding]; other site
394221000194	Q-loop/lid; other site
394221000195	ABC transporter signature motif; other site
394221000196	Walker B; other site
394221000197	D-loop; other site
394221000198	H-loop/switch region; other site
394221000199	Zinc-finger domain; Region: zf-CHCC; pfam10276
394221000200	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
394221000201	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
394221000202	transmembrane helices; other site
394221000203	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
394221000204	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
394221000205	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
394221000206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221000207	active site
394221000208	phosphorylation site [posttranslational modification]
394221000209	intermolecular recognition site; other site
394221000210	dimerization interface [polypeptide binding]; other site
394221000211	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
394221000212	DNA binding site [nucleotide binding]
394221000213	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
394221000214	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
394221000215	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221000216	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221000217	dimer interface [polypeptide binding]; other site
394221000218	phosphorylation site [posttranslational modification]
394221000219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221000220	ATP binding site [chemical binding]; other site
394221000221	Mg2+ binding site [ion binding]; other site
394221000222	G-X-G motif; other site
394221000223	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
394221000224	active pocket/dimerization site; other site
394221000225	active site
394221000226	phosphorylation site [posttranslational modification]
394221000227	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
394221000228	dimerization domain swap beta strand [polypeptide binding]; other site
394221000229	regulatory protein interface [polypeptide binding]; other site
394221000230	active site
394221000231	regulatory phosphorylation site [posttranslational modification]; other site
394221000232	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
394221000233	PAS fold; Region: PAS_7; pfam12860
394221000234	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
394221000235	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
394221000236	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221000237	dimer interface [polypeptide binding]; other site
394221000238	phosphorylation site [posttranslational modification]
394221000239	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221000240	ATP binding site [chemical binding]; other site
394221000241	Mg2+ binding site [ion binding]; other site
394221000242	G-X-G motif; other site
394221000243	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
394221000244	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
394221000245	catalytic loop [active]
394221000246	iron binding site [ion binding]; other site
394221000247	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
394221000248	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
394221000249	Phosphotransferase enzyme family; Region: APH; pfam01636
394221000250	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
394221000251	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
394221000252	Substrate binding site; other site
394221000253	metal-binding site
394221000254	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
394221000255	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
394221000256	Part of AAA domain; Region: AAA_19; pfam13245
394221000257	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
394221000258	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
394221000259	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
394221000260	catalytic residues [active]
394221000261	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
394221000262	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
394221000263	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
394221000264	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
394221000265	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
394221000266	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
394221000267	substrate binding site [chemical binding]; other site
394221000268	active site
394221000269	catalytic residues [active]
394221000270	heterodimer interface [polypeptide binding]; other site
394221000271	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
394221000272	Protein of unknown function (DUF497); Region: DUF497; pfam04365
394221000273	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
394221000274	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
394221000275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221000276	catalytic residue [active]
394221000277	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
394221000278	active site
394221000279	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
394221000280	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
394221000281	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
394221000282	dimerization interface [polypeptide binding]; other site
394221000283	substrate binding pocket [chemical binding]; other site
394221000284	SprA-related family; Region: SprA-related; pfam12118
394221000285	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
394221000286	IHF dimer interface [polypeptide binding]; other site
394221000287	IHF - DNA interface [nucleotide binding]; other site
394221000288	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
394221000289	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
394221000290	RNA binding site [nucleotide binding]; other site
394221000291	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
394221000292	RNA binding site [nucleotide binding]; other site
394221000293	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
394221000294	RNA binding site [nucleotide binding]; other site
394221000295	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
394221000296	RNA binding site [nucleotide binding]; other site
394221000297	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
394221000298	RNA binding site [nucleotide binding]; other site
394221000299	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
394221000300	RNA binding site [nucleotide binding]; other site
394221000301	cytidylate kinase; Provisional; Region: cmk; PRK00023
394221000302	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
394221000303	CMP-binding site; other site
394221000304	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
394221000305	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
394221000306	hinge; other site
394221000307	active site
394221000308	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
394221000309	TIGR02300 family protein; Region: FYDLN_acid
394221000310	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
394221000311	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
394221000312	active site
394221000313	phosphorylation site [posttranslational modification]
394221000314	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
394221000315	30S subunit binding site; other site
394221000316	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
394221000317	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
394221000318	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
394221000319	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
394221000320	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
394221000321	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
394221000322	Walker A/P-loop; other site
394221000323	ATP binding site [chemical binding]; other site
394221000324	Q-loop/lid; other site
394221000325	ABC transporter signature motif; other site
394221000326	Walker B; other site
394221000327	D-loop; other site
394221000328	H-loop/switch region; other site
394221000329	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
394221000330	OstA-like protein; Region: OstA; pfam03968
394221000331	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
394221000332	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
394221000333	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
394221000334	catalytic site [active]
394221000335	putative active site [active]
394221000336	putative substrate binding site [chemical binding]; other site
394221000337	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
394221000338	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
394221000339	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
394221000340	putative NAD(P) binding site [chemical binding]; other site
394221000341	active site
394221000342	CAAX protease self-immunity; Region: Abi; pfam02517
394221000343	Bacitracin resistance protein BacA; Region: BacA; pfam02673
394221000344	Cation efflux family; Region: Cation_efflux; cl00316
394221000345	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
394221000346	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
394221000347	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
394221000348	C-terminal domain interface [polypeptide binding]; other site
394221000349	GSH binding site (G-site) [chemical binding]; other site
394221000350	dimer interface [polypeptide binding]; other site
394221000351	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
394221000352	N-terminal domain interface [polypeptide binding]; other site
394221000353	dimer interface [polypeptide binding]; other site
394221000354	substrate binding pocket (H-site) [chemical binding]; other site
394221000355	epoxyqueuosine reductase; Region: TIGR00276
394221000356	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
394221000357	Response regulator receiver domain; Region: Response_reg; pfam00072
394221000358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221000359	active site
394221000360	phosphorylation site [posttranslational modification]
394221000361	intermolecular recognition site; other site
394221000362	dimerization interface [polypeptide binding]; other site
394221000363	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
394221000364	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
394221000365	metal binding site [ion binding]; metal-binding site
394221000366	active site
394221000367	I-site; other site
394221000368	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
394221000369	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
394221000370	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
394221000371	putative ADP-binding pocket [chemical binding]; other site
394221000372	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
394221000373	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
394221000374	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
394221000375	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
394221000376	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
394221000377	H+ Antiporter protein; Region: 2A0121; TIGR00900
394221000378	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221000379	putative substrate translocation pore; other site
394221000380	MerC mercury resistance protein; Region: MerC; pfam03203
394221000381	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
394221000382	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
394221000383	23S rRNA binding site [nucleotide binding]; other site
394221000384	L21 binding site [polypeptide binding]; other site
394221000385	L13 binding site [polypeptide binding]; other site
394221000386	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
394221000387	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
394221000388	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
394221000389	dimer interface [polypeptide binding]; other site
394221000390	motif 1; other site
394221000391	active site
394221000392	motif 2; other site
394221000393	motif 3; other site
394221000394	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
394221000395	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
394221000396	putative tRNA-binding site [nucleotide binding]; other site
394221000397	B3/4 domain; Region: B3_4; pfam03483
394221000398	tRNA synthetase B5 domain; Region: B5; smart00874
394221000399	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
394221000400	dimer interface [polypeptide binding]; other site
394221000401	motif 1; other site
394221000402	motif 3; other site
394221000403	motif 2; other site
394221000404	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
394221000405	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
394221000406	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
394221000407	Sel1-like repeats; Region: SEL1; smart00671
394221000408	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
394221000409	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
394221000410	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
394221000411	DNA binding residues [nucleotide binding]
394221000412	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
394221000413	dimer interface [polypeptide binding]; other site
394221000414	putative metal binding site [ion binding]; other site
394221000415	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
394221000416	Coenzyme A binding pocket [chemical binding]; other site
394221000417	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
394221000418	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
394221000419	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
394221000420	Peptidase family C69; Region: Peptidase_C69; cl17793
394221000421	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
394221000422	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
394221000423	active site
394221000424	Zn binding site [ion binding]; other site
394221000425	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
394221000426	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
394221000427	DNA binding residues [nucleotide binding]
394221000428	dimer interface [polypeptide binding]; other site
394221000429	[2Fe-2S] cluster binding site [ion binding]; other site
394221000430	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221000431	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
394221000432	active site
394221000433	metal binding site [ion binding]; metal-binding site
394221000434	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
394221000435	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
394221000436	[2Fe-2S] cluster binding site [ion binding]; other site
394221000437	C-terminal catalytic domain of plant choline monooxygenase (CMO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_CMO-like; cd08883
394221000438	putative alpha subunit interface [polypeptide binding]; other site
394221000439	putative active site [active]
394221000440	putative substrate binding site [chemical binding]; other site
394221000441	Fe binding site [ion binding]; other site
394221000442	arginine:agmatin antiporter; Provisional; Region: PRK10644
394221000443	GTP-binding protein LepA; Provisional; Region: PRK05433
394221000444	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
394221000445	G1 box; other site
394221000446	putative GEF interaction site [polypeptide binding]; other site
394221000447	GTP/Mg2+ binding site [chemical binding]; other site
394221000448	Switch I region; other site
394221000449	G2 box; other site
394221000450	G3 box; other site
394221000451	Switch II region; other site
394221000452	G4 box; other site
394221000453	G5 box; other site
394221000454	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
394221000455	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
394221000456	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
394221000457	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
394221000458	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
394221000459	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
394221000460	ligand binding site [chemical binding]; other site
394221000461	NAD binding site [chemical binding]; other site
394221000462	tetramer interface [polypeptide binding]; other site
394221000463	catalytic site [active]
394221000464	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
394221000465	L-serine binding site [chemical binding]; other site
394221000466	ACT domain interface; other site
394221000467	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
394221000468	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
394221000469	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
394221000470	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
394221000471	motif II; other site
394221000472	methionine sulfoxide reductase A; Provisional; Region: PRK00058
394221000473	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
394221000474	active site
394221000475	DNA binding site [nucleotide binding]
394221000476	Int/Topo IB signature motif; other site
394221000477	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221000478	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221000479	non-specific DNA binding site [nucleotide binding]; other site
394221000480	salt bridge; other site
394221000481	sequence-specific DNA binding site [nucleotide binding]; other site
394221000482	WYL domain; Region: WYL; pfam13280
394221000483	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
394221000484	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
394221000485	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
394221000486	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
394221000487	ATP binding site [chemical binding]; other site
394221000488	putative Mg++ binding site [ion binding]; other site
394221000489	nucleotide binding region [chemical binding]; other site
394221000490	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
394221000491	ATP-binding site [chemical binding]; other site
394221000492	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
394221000493	HsdM N-terminal domain; Region: HsdM_N; pfam12161
394221000494	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221000495	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
394221000496	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
394221000497	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
394221000498	Uncharacterized conserved protein [Function unknown]; Region: COG3586
394221000499	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221000500	AAA domain; Region: AAA_23; pfam13476
394221000501	Walker A/P-loop; other site
394221000502	ATP binding site [chemical binding]; other site
394221000503	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
394221000504	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
394221000505	AAA domain; Region: AAA_17; pfam13207
394221000506	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
394221000507	active site
394221000508	metal binding site [ion binding]; metal-binding site
394221000509	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
394221000510	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
394221000511	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
394221000512	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
394221000513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221000514	S-adenosylmethionine binding site [chemical binding]; other site
394221000515	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
394221000516	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
394221000517	catalytic residues [active]
394221000518	catalytic nucleophile [active]
394221000519	Recombinase; Region: Recombinase; pfam07508
394221000520	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
394221000521	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
394221000522	DDE domain; Region: DDE_Tnp_IS240; pfam13610
394221000523	Integrase core domain; Region: rve; pfam00665
394221000524	Outer membrane efflux protein; Region: OEP; pfam02321
394221000525	Outer membrane efflux protein; Region: OEP; pfam02321
394221000526	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
394221000527	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221000528	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
394221000529	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
394221000530	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
394221000531	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
394221000532	DNA binding residues [nucleotide binding]
394221000533	dimer interface [polypeptide binding]; other site
394221000534	copper binding site [ion binding]; other site
394221000535	YHS domain; Region: YHS; pfam04945
394221000536	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
394221000537	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
394221000538	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
394221000539	motif II; other site
394221000540	Amino acid permease; Region: AA_permease_2; pfam13520
394221000541	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
394221000542	pseudoazurin; Region: pseudoazurin; TIGR02375
394221000543	Cytochrome c; Region: Cytochrom_C; pfam00034
394221000544	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
394221000545	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
394221000546	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
394221000547	[2Fe-2S] cluster binding site [ion binding]; other site
394221000548	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
394221000549	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
394221000550	XFP N-terminal domain; Region: XFP_N; pfam09364
394221000551	Nitrogen regulatory protein P-II; Region: P-II; cl00412
394221000552	Nitrogen regulatory protein P-II; Region: P-II; smart00938
394221000553	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
394221000554	propionate/acetate kinase; Provisional; Region: PRK12379
394221000555	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
394221000556	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
394221000557	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
394221000558	active site
394221000559	thymidine phosphorylase; Provisional; Region: PRK04350
394221000560	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
394221000561	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
394221000562	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
394221000563	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
394221000564	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
394221000565	Beta-Casp domain; Region: Beta-Casp; smart01027
394221000566	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
394221000567	FtsH Extracellular; Region: FtsH_ext; pfam06480
394221000568	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
394221000569	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221000570	Walker A motif; other site
394221000571	ATP binding site [chemical binding]; other site
394221000572	Walker B motif; other site
394221000573	arginine finger; other site
394221000574	Peptidase family M41; Region: Peptidase_M41; pfam01434
394221000575	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
394221000576	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
394221000577	active site
394221000578	cosubstrate binding site; other site
394221000579	catalytic site [active]
394221000580	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
394221000581	SnoaL-like domain; Region: SnoaL_3; pfam13474
394221000582	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
394221000583	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
394221000584	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
394221000585	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
394221000586	DNA binding residues [nucleotide binding]
394221000587	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
394221000588	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
394221000589	Multicopper oxidase; Region: Cu-oxidase; pfam00394
394221000590	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
394221000591	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
394221000592	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
394221000593	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
394221000594	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221000595	dimerization interface [polypeptide binding]; other site
394221000596	putative DNA binding site [nucleotide binding]; other site
394221000597	putative Zn2+ binding site [ion binding]; other site
394221000598	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221000599	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221000600	non-specific DNA binding site [nucleotide binding]; other site
394221000601	salt bridge; other site
394221000602	sequence-specific DNA binding site [nucleotide binding]; other site
394221000603	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
394221000604	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
394221000605	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
394221000606	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
394221000607	Helix-turn-helix domain; Region: HTH_18; pfam12833
394221000608	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
394221000609	Predicted metal-binding protein [General function prediction only]; Region: COG3019
394221000610	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
394221000611	DDE domain; Region: DDE_Tnp_IS240; pfam13610
394221000612	Integrase core domain; Region: rve; pfam00665
394221000613	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
394221000614	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
394221000615	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
394221000616	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
394221000617	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
394221000618	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
394221000619	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221000620	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221000621	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
394221000622	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221000623	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
394221000624	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
394221000625	substrate binding pocket [chemical binding]; other site
394221000626	catalytic triad [active]
394221000627	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
394221000628	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
394221000629	substrate binding site [chemical binding]; other site
394221000630	ATP binding site [chemical binding]; other site
394221000631	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
394221000632	galactarate dehydratase; Region: galactar-dH20; TIGR03248
394221000633	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
394221000634	Transcriptional regulators [Transcription]; Region: PurR; COG1609
394221000635	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
394221000636	DNA binding site [nucleotide binding]
394221000637	domain linker motif; other site
394221000638	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
394221000639	putative dimerization interface [polypeptide binding]; other site
394221000640	putative ligand binding site [chemical binding]; other site
394221000641	glucuronate isomerase; Reviewed; Region: PRK02925
394221000642	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
394221000643	hypothetical protein; Provisional; Region: PRK09273
394221000644	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
394221000645	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
394221000646	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
394221000647	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
394221000648	NADP binding site [chemical binding]; other site
394221000649	homodimer interface [polypeptide binding]; other site
394221000650	active site
394221000651	DctM-like transporters; Region: DctM; pfam06808
394221000652	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
394221000653	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
394221000654	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
394221000655	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
394221000656	Pectate lyase; Region: Pec_lyase_C; cl01593
394221000657	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
394221000658	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
394221000659	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
394221000660	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221000661	putative Zn2+ binding site [ion binding]; other site
394221000662	putative DNA binding site [nucleotide binding]; other site
394221000663	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
394221000664	active site residue [active]
394221000665	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
394221000666	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
394221000667	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221000668	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
394221000669	Protein export membrane protein; Region: SecD_SecF; cl14618
394221000670	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
394221000671	Transcriptional regulators [Transcription]; Region: PurR; COG1609
394221000672	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
394221000673	DNA binding site [nucleotide binding]
394221000674	domain linker motif; other site
394221000675	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
394221000676	putative ligand binding site [chemical binding]; other site
394221000677	putative dimerization interface [polypeptide binding]; other site
394221000678	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221000679	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
394221000680	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221000681	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221000682	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
394221000683	active site
394221000684	catalytic residues [active]
394221000685	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
394221000686	MFS/sugar transport protein; Region: MFS_2; pfam13347
394221000687	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
394221000688	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
394221000689	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
394221000690	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
394221000691	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
394221000692	Autotransporter beta-domain; Region: Autotransporter; smart00869
394221000693	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
394221000694	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
394221000695	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221000696	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221000697	Transcriptional regulators [Transcription]; Region: FadR; COG2186
394221000698	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
394221000699	DNA-binding site [nucleotide binding]; DNA binding site
394221000700	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
394221000701	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
394221000702	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
394221000703	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
394221000704	Cupin domain; Region: Cupin_2; pfam07883
394221000705	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221000706	Major Facilitator Superfamily; Region: MFS_1; pfam07690
394221000707	putative substrate translocation pore; other site
394221000708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221000709	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
394221000710	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221000711	NAD(P) binding site [chemical binding]; other site
394221000712	active site
394221000713	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
394221000714	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
394221000715	substrate binding site [chemical binding]; other site
394221000716	ATP binding site [chemical binding]; other site
394221000717	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
394221000718	Autotransporter beta-domain; Region: Autotransporter; smart00869
394221000719	short chain dehydrogenase; Provisional; Region: PRK12828
394221000720	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221000721	NAD(P) binding site [chemical binding]; other site
394221000722	active site
394221000723	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
394221000724	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
394221000725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
394221000726	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
394221000727	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221000728	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
394221000729	Protein export membrane protein; Region: SecD_SecF; cl14618
394221000730	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
394221000731	enoyl-CoA hydratase; Provisional; Region: PRK06127
394221000732	substrate binding site [chemical binding]; other site
394221000733	oxyanion hole (OAH) forming residues; other site
394221000734	trimer interface [polypeptide binding]; other site
394221000735	MFS/sugar transport protein; Region: MFS_2; pfam13347
394221000736	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
394221000737	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
394221000738	metal binding site [ion binding]; metal-binding site
394221000739	active site
394221000740	I-site; other site
394221000741	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
394221000742	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
394221000743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221000744	S-adenosylmethionine binding site [chemical binding]; other site
394221000745	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
394221000746	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
394221000747	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
394221000748	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
394221000749	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
394221000750	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
394221000751	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
394221000752	DNA binding residues [nucleotide binding]
394221000753	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
394221000754	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
394221000755	Transcriptional regulators [Transcription]; Region: PurR; COG1609
394221000756	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
394221000757	DNA binding site [nucleotide binding]
394221000758	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
394221000759	putative dimerization interface [polypeptide binding]; other site
394221000760	putative ligand binding site [chemical binding]; other site
394221000761	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
394221000762	anti sigma factor interaction site; other site
394221000763	regulatory phosphorylation site [posttranslational modification]; other site
394221000764	Response regulator receiver domain; Region: Response_reg; pfam00072
394221000765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221000766	active site
394221000767	phosphorylation site [posttranslational modification]
394221000768	intermolecular recognition site; other site
394221000769	dimerization interface [polypeptide binding]; other site
394221000770	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
394221000771	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
394221000772	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
394221000773	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
394221000774	active site
394221000775	dimer interface [polypeptide binding]; other site
394221000776	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
394221000777	tartrate dehydrogenase; Region: TTC; TIGR02089
394221000778	3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066
394221000779	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
394221000780	substrate binding site [chemical binding]; other site
394221000781	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
394221000782	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
394221000783	substrate binding site [chemical binding]; other site
394221000784	ligand binding site [chemical binding]; other site
394221000785	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
394221000786	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
394221000787	homodimer interface [polypeptide binding]; other site
394221000788	substrate-cofactor binding pocket; other site
394221000789	catalytic residue [active]
394221000790	2-isopropylmalate synthase; Validated; Region: PRK00915
394221000791	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
394221000792	active site
394221000793	catalytic residues [active]
394221000794	metal binding site [ion binding]; metal-binding site
394221000795	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
394221000796	ACT domain; Region: ACT_5; pfam13710
394221000797	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
394221000798	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
394221000799	PYR/PP interface [polypeptide binding]; other site
394221000800	dimer interface [polypeptide binding]; other site
394221000801	TPP binding site [chemical binding]; other site
394221000802	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
394221000803	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
394221000804	TPP-binding site [chemical binding]; other site
394221000805	dimer interface [polypeptide binding]; other site
394221000806	ketol-acid reductoisomerase; Provisional; Region: PRK05479
394221000807	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
394221000808	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
394221000809	Dehydratase family; Region: ILVD_EDD; cl00340
394221000810	Protein of unknown function (DUF454); Region: DUF454; pfam04304
394221000811	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
394221000812	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
394221000813	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
394221000814	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
394221000815	active site
394221000816	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
394221000817	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
394221000818	inhibitor site; inhibition site
394221000819	active site
394221000820	dimer interface [polypeptide binding]; other site
394221000821	catalytic residue [active]
394221000822	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
394221000823	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
394221000824	Transcriptional regulators [Transcription]; Region: GntR; COG1802
394221000825	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
394221000826	DNA-binding site [nucleotide binding]; DNA binding site
394221000827	FCD domain; Region: FCD; pfam07729
394221000828	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
394221000829	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
394221000830	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
394221000831	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
394221000832	active site
394221000833	dimer interface [polypeptide binding]; other site
394221000834	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
394221000835	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
394221000836	active site
394221000837	FMN binding site [chemical binding]; other site
394221000838	substrate binding site [chemical binding]; other site
394221000839	3Fe-4S cluster binding site [ion binding]; other site
394221000840	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
394221000841	domain interface; other site
394221000842	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
394221000843	dimer interface [polypeptide binding]; other site
394221000844	substrate binding site [chemical binding]; other site
394221000845	metal binding sites [ion binding]; metal-binding site
394221000846	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
394221000847	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221000848	catalytic residue [active]
394221000849	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
394221000850	Class III ribonucleotide reductase; Region: RNR_III; cd01675
394221000851	effector binding site; other site
394221000852	active site
394221000853	Zn binding site [ion binding]; other site
394221000854	glycine loop; other site
394221000855	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
394221000856	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
394221000857	FeS/SAM binding site; other site
394221000858	NnrS protein; Region: NnrS; pfam05940
394221000859	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
394221000860	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
394221000861	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
394221000862	active site 2 [active]
394221000863	active site 1 [active]
394221000864	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
394221000865	active site 2 [active]
394221000866	active site 1 [active]
394221000867	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
394221000868	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
394221000869	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
394221000870	acyl-activating enzyme (AAE) consensus motif; other site
394221000871	acyl-activating enzyme (AAE) consensus motif; other site
394221000872	putative AMP binding site [chemical binding]; other site
394221000873	putative active site [active]
394221000874	putative CoA binding site [chemical binding]; other site
394221000875	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
394221000876	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
394221000877	substrate binding site [chemical binding]; other site
394221000878	oxyanion hole (OAH) forming residues; other site
394221000879	trimer interface [polypeptide binding]; other site
394221000880	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221000881	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221000882	WHG domain; Region: WHG; pfam13305
394221000883	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
394221000884	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
394221000885	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221000886	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
394221000887	N-terminal plug; other site
394221000888	ligand-binding site [chemical binding]; other site
394221000889	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
394221000890	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221000891	Penicillinase repressor; Region: Pencillinase_R; cl17580
394221000892	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
394221000893	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
394221000894	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
394221000895	Na binding site [ion binding]; other site
394221000896	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
394221000897	Uncharacterized conserved protein [Function unknown]; Region: COG3791
394221000898	PhoH-like protein; Region: PhoH; pfam02562
394221000899	Predicted integral membrane protein [Function unknown]; Region: COG5616
394221000900	Predicted integral membrane protein [Function unknown]; Region: COG5616
394221000901	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221000902	binding surface
394221000903	TPR motif; other site
394221000904	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
394221000905	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
394221000906	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
394221000907	DNA binding residues [nucleotide binding]
394221000908	dimerization interface [polypeptide binding]; other site
394221000909	Predicted integral membrane protein [Function unknown]; Region: COG5616
394221000910	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
394221000911	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221000912	Zn binding site [ion binding]; other site
394221000913	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
394221000914	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
394221000915	dimer interface [polypeptide binding]; other site
394221000916	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
394221000917	active site
394221000918	Fe binding site [ion binding]; other site
394221000919	Transcriptional regulators [Transcription]; Region: MarR; COG1846
394221000920	MarR family; Region: MarR_2; pfam12802
394221000921	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
394221000922	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
394221000923	G1 box; other site
394221000924	putative GEF interaction site [polypeptide binding]; other site
394221000925	GTP/Mg2+ binding site [chemical binding]; other site
394221000926	Switch I region; other site
394221000927	G2 box; other site
394221000928	G3 box; other site
394221000929	Switch II region; other site
394221000930	G4 box; other site
394221000931	G5 box; other site
394221000932	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
394221000933	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
394221000934	Predicted helicase [General function prediction only]; Region: COG4889
394221000935	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
394221000936	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
394221000937	FAD binding pocket [chemical binding]; other site
394221000938	FAD binding motif [chemical binding]; other site
394221000939	phosphate binding motif [ion binding]; other site
394221000940	beta-alpha-beta structure motif; other site
394221000941	NAD binding pocket [chemical binding]; other site
394221000942	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
394221000943	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
394221000944	dimer interface [polypeptide binding]; other site
394221000945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221000946	catalytic residue [active]
394221000947	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
394221000948	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
394221000949	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
394221000950	Active Sites [active]
394221000951	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
394221000952	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
394221000953	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
394221000954	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
394221000955	siroheme synthase; Provisional; Region: cysG; PRK10637
394221000956	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
394221000957	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
394221000958	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
394221000959	active site
394221000960	SAM binding site [chemical binding]; other site
394221000961	homodimer interface [polypeptide binding]; other site
394221000962	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
394221000963	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
394221000964	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
394221000965	dimerization interface [polypeptide binding]; other site
394221000966	substrate binding pocket [chemical binding]; other site
394221000967	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
394221000968	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
394221000969	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
394221000970	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
394221000971	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
394221000972	dimer interface [polypeptide binding]; other site
394221000973	PYR/PP interface [polypeptide binding]; other site
394221000974	TPP binding site [chemical binding]; other site
394221000975	substrate binding site [chemical binding]; other site
394221000976	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
394221000977	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
394221000978	TPP-binding site [chemical binding]; other site
394221000979	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
394221000980	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221000981	non-specific DNA binding site [nucleotide binding]; other site
394221000982	salt bridge; other site
394221000983	sequence-specific DNA binding site [nucleotide binding]; other site
394221000984	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221000985	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221000986	non-specific DNA binding site [nucleotide binding]; other site
394221000987	salt bridge; other site
394221000988	sequence-specific DNA binding site [nucleotide binding]; other site
394221000989	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221000990	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221000991	non-specific DNA binding site [nucleotide binding]; other site
394221000992	salt bridge; other site
394221000993	sequence-specific DNA binding site [nucleotide binding]; other site
394221000994	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221000995	non-specific DNA binding site [nucleotide binding]; other site
394221000996	salt bridge; other site
394221000997	sequence-specific DNA binding site [nucleotide binding]; other site
394221000998	PAS domain; Region: PAS_9; pfam13426
394221000999	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
394221001000	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
394221001001	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
394221001002	PA/protease or protease-like domain interface [polypeptide binding]; other site
394221001003	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
394221001004	metal binding site [ion binding]; metal-binding site
394221001005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221001006	Major Facilitator Superfamily; Region: MFS_1; pfam07690
394221001007	putative substrate translocation pore; other site
394221001008	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
394221001009	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
394221001010	catalytic core [active]
394221001011	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
394221001012	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
394221001013	Ligand binding site; other site
394221001014	oligomer interface; other site
394221001015	N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523
394221001016	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
394221001017	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
394221001018	acetylglutamate kinase; Provisional; Region: PRK04531
394221001019	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
394221001020	nucleotide binding site [chemical binding]; other site
394221001021	substrate binding site [chemical binding]; other site
394221001022	DUF619 domain of various N-acetylglutamate Synthases of the fungal arginine-biosynthetic pathway and urea cycle found in humans and fish; Region: DUF619-NAGS; cd04264
394221001023	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
394221001024	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
394221001025	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
394221001026	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
394221001027	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
394221001028	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221001029	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221001030	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
394221001031	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
394221001032	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221001033	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221001034	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
394221001035	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
394221001036	putative active site; other site
394221001037	catalytic triad [active]
394221001038	putative dimer interface [polypeptide binding]; other site
394221001039	MarC family integral membrane protein; Region: MarC; pfam01914
394221001040	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
394221001041	deoxyhypusine synthase; Region: dhys; TIGR00321
394221001042	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
394221001043	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
394221001044	dimer interface [polypeptide binding]; other site
394221001045	active site
394221001046	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
394221001047	catalytic residues [active]
394221001048	substrate binding site [chemical binding]; other site
394221001049	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
394221001050	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221001051	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
394221001052	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
394221001053	type II secretion system protein D; Region: type_II_gspD; TIGR02517
394221001054	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
394221001055	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
394221001056	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
394221001057	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
394221001058	type II secretion system protein E; Region: type_II_gspE; TIGR02533
394221001059	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
394221001060	Walker A motif; other site
394221001061	ATP binding site [chemical binding]; other site
394221001062	Walker B motif; other site
394221001063	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
394221001064	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
394221001065	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
394221001066	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
394221001067	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
394221001068	Type II transport protein GspH; Region: GspH; pfam12019
394221001069	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
394221001070	type II secretion system protein J; Region: gspJ; TIGR01711
394221001071	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
394221001072	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
394221001073	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
394221001074	GspL periplasmic domain; Region: GspL_C; cl14909
394221001075	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
394221001076	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
394221001077	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
394221001078	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
394221001079	Walker A/P-loop; other site
394221001080	ATP binding site [chemical binding]; other site
394221001081	Q-loop/lid; other site
394221001082	ABC transporter signature motif; other site
394221001083	Walker B; other site
394221001084	D-loop; other site
394221001085	H-loop/switch region; other site
394221001086	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
394221001087	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
394221001088	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
394221001089	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
394221001090	dimer interface [polypeptide binding]; other site
394221001091	conserved gate region; other site
394221001092	ABC-ATPase subunit interface; other site
394221001093	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
394221001094	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
394221001095	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
394221001096	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
394221001097	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
394221001098	Proline dehydrogenase; Region: Pro_dh; pfam01619
394221001099	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
394221001100	Glutamate binding site [chemical binding]; other site
394221001101	NAD binding site [chemical binding]; other site
394221001102	catalytic residues [active]
394221001103	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
394221001104	Class I ribonucleotide reductase; Region: RNR_I; cd01679
394221001105	active site
394221001106	dimer interface [polypeptide binding]; other site
394221001107	catalytic residues [active]
394221001108	effector binding site; other site
394221001109	R2 peptide binding site; other site
394221001110	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409
394221001111	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
394221001112	dimer interface [polypeptide binding]; other site
394221001113	putative radical transfer pathway; other site
394221001114	diiron center [ion binding]; other site
394221001115	tyrosyl radical; other site
394221001116	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
394221001117	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
394221001118	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
394221001119	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
394221001120	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
394221001121	bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961
394221001122	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
394221001123	nucleotide binding site [chemical binding]; other site
394221001124	substrate binding site [chemical binding]; other site
394221001125	ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935
394221001126	ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC); Region: ACT_AKiii-DAPDC_2; cd04920
394221001127	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bifunctional Aspartate Kinase/Diaminopimelate Decarboxylase; Region: PLPDE_III_Bif_AspK_DapDC; cd06840
394221001128	active site
394221001129	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
394221001130	substrate binding site [chemical binding]; other site
394221001131	catalytic residues [active]
394221001132	dimer interface [polypeptide binding]; other site
394221001133	AMP nucleosidase; Provisional; Region: PRK08292
394221001134	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
394221001135	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
394221001136	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
394221001137	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
394221001138	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
394221001139	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
394221001140	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
394221001141	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
394221001142	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
394221001143	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
394221001144	homodimer interface [polypeptide binding]; other site
394221001145	substrate-cofactor binding pocket; other site
394221001146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221001147	catalytic residue [active]
394221001148	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
394221001149	TadE-like protein; Region: TadE; pfam07811
394221001150	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
394221001151	TadE-like protein; Region: TadE; pfam07811
394221001152	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
394221001153	Flp/Fap pilin component; Region: Flp_Fap; cl01585
394221001154	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
394221001155	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
394221001156	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
394221001157	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
394221001158	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
394221001159	BON domain; Region: BON; pfam04972
394221001160	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
394221001161	Type IV pili component [Cell motility and secretion]; Region: COG5461
394221001162	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
394221001163	Response regulator receiver domain; Region: Response_reg; pfam00072
394221001164	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
394221001165	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
394221001166	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
394221001167	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
394221001168	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
394221001169	ATP binding site [chemical binding]; other site
394221001170	Walker A motif; other site
394221001171	hexamer interface [polypeptide binding]; other site
394221001172	Walker B motif; other site
394221001173	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
394221001174	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
394221001175	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
394221001176	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
394221001177	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221001178	binding surface
394221001179	TPR motif; other site
394221001180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221001181	binding surface
394221001182	TPR motif; other site
394221001183	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
394221001184	interface (dimer of trimers) [polypeptide binding]; other site
394221001185	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
394221001186	Substrate-binding/catalytic site; other site
394221001187	Zn-binding sites [ion binding]; other site
394221001188	MarR family; Region: MarR_2; pfam12802
394221001189	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
394221001190	NlpC/P60 family; Region: NLPC_P60; cl17555
394221001191	Cytochrome c; Region: Cytochrom_C; cl11414
394221001192	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
394221001193	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
394221001194	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
394221001195	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
394221001196	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
394221001197	putative NADH binding site [chemical binding]; other site
394221001198	putative active site [active]
394221001199	nudix motif; other site
394221001200	putative metal binding site [ion binding]; other site
394221001201	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
394221001202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221001203	Walker A motif; other site
394221001204	ATP binding site [chemical binding]; other site
394221001205	Walker B motif; other site
394221001206	arginine finger; other site
394221001207	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
394221001208	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
394221001209	hypothetical protein; Validated; Region: PRK00153
394221001210	recombination protein RecR; Reviewed; Region: recR; PRK00076
394221001211	RecR protein; Region: RecR; pfam02132
394221001212	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
394221001213	putative active site [active]
394221001214	putative metal-binding site [ion binding]; other site
394221001215	tetramer interface [polypeptide binding]; other site
394221001216	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
394221001217	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
394221001218	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
394221001219	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
394221001220	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
394221001221	RmuC family; Region: RmuC; pfam02646
394221001222	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
394221001223	active site
394221001224	catalytic residues [active]
394221001225	metal binding site [ion binding]; metal-binding site
394221001226	Pirin-related protein [General function prediction only]; Region: COG1741
394221001227	Pirin; Region: Pirin; pfam02678
394221001228	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
394221001229	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
394221001230	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
394221001231	putative active site [active]
394221001232	substrate binding site [chemical binding]; other site
394221001233	putative cosubstrate binding site; other site
394221001234	catalytic site [active]
394221001235	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
394221001236	substrate binding site [chemical binding]; other site
394221001237	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
394221001238	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
394221001239	dimerization interface 3.5A [polypeptide binding]; other site
394221001240	active site
394221001241	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
394221001242	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
394221001243	metal binding site [ion binding]; metal-binding site
394221001244	dimer interface [polypeptide binding]; other site
394221001245	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
394221001246	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
394221001247	Coenzyme A binding pocket [chemical binding]; other site
394221001248	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
394221001249	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
394221001250	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
394221001251	trimer interface [polypeptide binding]; other site
394221001252	active site
394221001253	substrate binding site [chemical binding]; other site
394221001254	CoA binding site [chemical binding]; other site
394221001255	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
394221001256	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
394221001257	active site
394221001258	motif I; other site
394221001259	motif II; other site
394221001260	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
394221001261	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
394221001262	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
394221001263	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
394221001264	G1 box; other site
394221001265	GTP/Mg2+ binding site [chemical binding]; other site
394221001266	Switch I region; other site
394221001267	G2 box; other site
394221001268	G3 box; other site
394221001269	Switch II region; other site
394221001270	G4 box; other site
394221001271	G5 box; other site
394221001272	membrane protein insertase; Provisional; Region: PRK01318
394221001273	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
394221001274	Ribonuclease P; Region: Ribonuclease_P; pfam00825
394221001275	Uncharacterized conserved protein [Function unknown]; Region: COG0398
394221001276	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
394221001277	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221001278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221001279	ATP binding site [chemical binding]; other site
394221001280	Mg2+ binding site [ion binding]; other site
394221001281	G-X-G motif; other site
394221001282	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
394221001283	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
394221001284	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
394221001285	putative active site pocket [active]
394221001286	cleavage site
394221001287	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
394221001288	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
394221001289	dimer interface [polypeptide binding]; other site
394221001290	putative CheW interface [polypeptide binding]; other site
394221001291	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
394221001292	conserved cys residue [active]
394221001293	putative MFS family transporter protein; Provisional; Region: PRK03633
394221001294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221001295	putative substrate translocation pore; other site
394221001296	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
394221001297	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221001298	putative DNA binding site [nucleotide binding]; other site
394221001299	putative Zn2+ binding site [ion binding]; other site
394221001300	AsnC family; Region: AsnC_trans_reg; pfam01037
394221001301	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
394221001302	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
394221001303	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221001304	catalytic residue [active]
394221001305	Protein of unknown function (DUF819); Region: DUF819; cl02317
394221001306	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
394221001307	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
394221001308	active site
394221001309	Zn binding site [ion binding]; other site
394221001310	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
394221001311	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
394221001312	active site
394221001313	Zn binding site [ion binding]; other site
394221001314	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
394221001315	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
394221001316	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221001317	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
394221001318	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
394221001319	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221001320	dimer interface [polypeptide binding]; other site
394221001321	phosphorylation site [posttranslational modification]
394221001322	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221001323	ATP binding site [chemical binding]; other site
394221001324	Mg2+ binding site [ion binding]; other site
394221001325	G-X-G motif; other site
394221001326	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
394221001327	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
394221001328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
394221001329	dimer interface [polypeptide binding]; other site
394221001330	conserved gate region; other site
394221001331	putative PBP binding loops; other site
394221001332	ABC-ATPase subunit interface; other site
394221001333	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
394221001334	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
394221001335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
394221001336	dimer interface [polypeptide binding]; other site
394221001337	conserved gate region; other site
394221001338	putative PBP binding loops; other site
394221001339	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
394221001340	ABC-ATPase subunit interface; other site
394221001341	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
394221001342	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
394221001343	Walker A/P-loop; other site
394221001344	ATP binding site [chemical binding]; other site
394221001345	Q-loop/lid; other site
394221001346	ABC transporter signature motif; other site
394221001347	Walker B; other site
394221001348	D-loop; other site
394221001349	H-loop/switch region; other site
394221001350	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
394221001351	PhoU domain; Region: PhoU; pfam01895
394221001352	PhoU domain; Region: PhoU; pfam01895
394221001353	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
394221001354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221001355	active site
394221001356	phosphorylation site [posttranslational modification]
394221001357	intermolecular recognition site; other site
394221001358	dimerization interface [polypeptide binding]; other site
394221001359	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
394221001360	DNA binding site [nucleotide binding]
394221001361	GcrA cell cycle regulator; Region: GcrA; cl11564
394221001362	ABC-2 type transporter; Region: ABC2_membrane; cl17235
394221001363	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
394221001364	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
394221001365	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
394221001366	inhibitor-cofactor binding pocket; inhibition site
394221001367	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221001368	catalytic residue [active]
394221001369	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
394221001370	dimerization interface [polypeptide binding]; other site
394221001371	domain crossover interface; other site
394221001372	redox-dependent activation switch; other site
394221001373	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
394221001374	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
394221001375	metal binding site [ion binding]; metal-binding site
394221001376	active site
394221001377	I-site; other site
394221001378	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
394221001379	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
394221001380	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
394221001381	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
394221001382	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
394221001383	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
394221001384	trimer interface [polypeptide binding]; other site
394221001385	active site
394221001386	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
394221001387	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
394221001388	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221001389	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
394221001390	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221001391	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
394221001392	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221001393	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
394221001394	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
394221001395	DXD motif; other site
394221001396	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
394221001397	catalytic core [active]
394221001398	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
394221001399	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
394221001400	dimer interface [polypeptide binding]; other site
394221001401	decamer (pentamer of dimers) interface [polypeptide binding]; other site
394221001402	catalytic triad [active]
394221001403	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221001404	non-specific DNA binding site [nucleotide binding]; other site
394221001405	salt bridge; other site
394221001406	sequence-specific DNA binding site [nucleotide binding]; other site
394221001407	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
394221001408	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
394221001409	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
394221001410	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
394221001411	Walker A/P-loop; other site
394221001412	ATP binding site [chemical binding]; other site
394221001413	Q-loop/lid; other site
394221001414	ABC transporter signature motif; other site
394221001415	Walker B; other site
394221001416	D-loop; other site
394221001417	H-loop/switch region; other site
394221001418	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221001419	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221001420	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221001421	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
394221001422	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
394221001423	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
394221001424	active site
394221001425	nucleotide binding site [chemical binding]; other site
394221001426	HIGH motif; other site
394221001427	KMSKS motif; other site
394221001428	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221001429	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221001430	non-specific DNA binding site [nucleotide binding]; other site
394221001431	salt bridge; other site
394221001432	sequence-specific DNA binding site [nucleotide binding]; other site
394221001433	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221001434	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
394221001435	Cytochrome P450; Region: p450; cl12078
394221001436	Predicted transcriptional regulator [Transcription]; Region: COG2932
394221001437	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
394221001438	Catalytic site [active]
394221001439	Protein of unknown function (DUF952); Region: DUF952; pfam06108
394221001440	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
394221001441	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
394221001442	quinone interaction residues [chemical binding]; other site
394221001443	active site
394221001444	catalytic residues [active]
394221001445	FMN binding site [chemical binding]; other site
394221001446	substrate binding site [chemical binding]; other site
394221001447	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
394221001448	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
394221001449	Protein of unknown function, DUF393; Region: DUF393; pfam04134
394221001450	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
394221001451	CoenzymeA binding site [chemical binding]; other site
394221001452	subunit interaction site [polypeptide binding]; other site
394221001453	PHB binding site; other site
394221001454	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
394221001455	CoenzymeA binding site [chemical binding]; other site
394221001456	subunit interaction site [polypeptide binding]; other site
394221001457	PHB binding site; other site
394221001458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221001459	Response regulator receiver domain; Region: Response_reg; pfam00072
394221001460	active site
394221001461	phosphorylation site [posttranslational modification]
394221001462	intermolecular recognition site; other site
394221001463	dimerization interface [polypeptide binding]; other site
394221001464	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
394221001465	Mechanosensitive ion channel; Region: MS_channel; pfam00924
394221001466	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
394221001467	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
394221001468	ATP binding site [chemical binding]; other site
394221001469	putative Mg++ binding site [ion binding]; other site
394221001470	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
394221001471	nucleotide binding region [chemical binding]; other site
394221001472	ATP-binding site [chemical binding]; other site
394221001473	DEAD/H associated; Region: DEAD_assoc; pfam08494
394221001474	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
394221001475	putative active site [active]
394221001476	putative metal binding site [ion binding]; other site
394221001477	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
394221001478	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
394221001479	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
394221001480	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
394221001481	Sel1-like repeats; Region: SEL1; smart00671
394221001482	Sel1-like repeats; Region: SEL1; smart00671
394221001483	Sel1-like repeats; Region: SEL1; smart00671
394221001484	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
394221001485	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
394221001486	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
394221001487	DNA binding residues [nucleotide binding]
394221001488	putative dimer interface [polypeptide binding]; other site
394221001489	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
394221001490	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
394221001491	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
394221001492	active site
394221001493	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
394221001494	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
394221001495	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
394221001496	active site
394221001497	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
394221001498	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
394221001499	putative active site [active]
394221001500	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
394221001501	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
394221001502	dimer interface [polypeptide binding]; other site
394221001503	active site
394221001504	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
394221001505	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
394221001506	substrate binding site [chemical binding]; other site
394221001507	oxyanion hole (OAH) forming residues; other site
394221001508	trimer interface [polypeptide binding]; other site
394221001509	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
394221001510	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
394221001511	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
394221001512	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
394221001513	active site
394221001514	NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559
394221001515	NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559
394221001516	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
394221001517	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
394221001518	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
394221001519	N-terminal domain interface [polypeptide binding]; other site
394221001520	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
394221001521	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
394221001522	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
394221001523	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
394221001524	Transcriptional regulator [Transcription]; Region: LysR; COG0583
394221001525	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
394221001526	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
394221001527	putative effector binding pocket; other site
394221001528	dimerization interface [polypeptide binding]; other site
394221001529	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
394221001530	dimer interface [polypeptide binding]; other site
394221001531	substrate binding site [chemical binding]; other site
394221001532	ATP binding site [chemical binding]; other site
394221001533	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
394221001534	EamA-like transporter family; Region: EamA; pfam00892
394221001535	EamA-like transporter family; Region: EamA; pfam00892
394221001536	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
394221001537	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
394221001538	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221001539	catalytic residue [active]
394221001540	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
394221001541	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221001542	catalytic residue [active]
394221001543	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
394221001544	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
394221001545	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
394221001546	GDP-binding site [chemical binding]; other site
394221001547	ACT binding site; other site
394221001548	IMP binding site; other site
394221001549	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
394221001550	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
394221001551	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
394221001552	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221001553	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221001554	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
394221001555	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
394221001556	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
394221001557	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
394221001558	ThiC-associated domain; Region: ThiC-associated; pfam13667
394221001559	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
394221001560	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221001561	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221001562	non-specific DNA binding site [nucleotide binding]; other site
394221001563	salt bridge; other site
394221001564	sequence-specific DNA binding site [nucleotide binding]; other site
394221001565	Uncharacterized conserved protein [Function unknown]; Region: COG3791
394221001566	Protein of unknown function, DUF481; Region: DUF481; pfam04338
394221001567	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
394221001568	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
394221001569	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
394221001570	DNA binding residues [nucleotide binding]
394221001571	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
394221001572	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
394221001573	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
394221001574	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
394221001575	DNA binding residues [nucleotide binding]
394221001576	YhhN-like protein; Region: YhhN; pfam07947
394221001577	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
394221001578	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
394221001579	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
394221001580	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
394221001581	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
394221001582	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
394221001583	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
394221001584	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
394221001585	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221001586	Walker A/P-loop; other site
394221001587	ATP binding site [chemical binding]; other site
394221001588	Q-loop/lid; other site
394221001589	ABC transporter signature motif; other site
394221001590	Walker B; other site
394221001591	D-loop; other site
394221001592	H-loop/switch region; other site
394221001593	Thioesterase-like superfamily; Region: 4HBT_2; pfam13279
394221001594	active site 2 [active]
394221001595	active site 1 [active]
394221001596	Thioesterase-like superfamily; Region: 4HBT_2; pfam13279
394221001597	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
394221001598	metal binding site 2 [ion binding]; metal-binding site
394221001599	putative DNA binding helix; other site
394221001600	metal binding site 1 [ion binding]; metal-binding site
394221001601	dimer interface [polypeptide binding]; other site
394221001602	structural Zn2+ binding site [ion binding]; other site
394221001603	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
394221001604	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221001605	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221001606	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
394221001607	SapC; Region: SapC; pfam07277
394221001608	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
394221001609	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
394221001610	DsbD alpha interface [polypeptide binding]; other site
394221001611	catalytic residues [active]
394221001612	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
394221001613	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
394221001614	dimer interface [polypeptide binding]; other site
394221001615	motif 1; other site
394221001616	motif 2; other site
394221001617	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
394221001618	active site
394221001619	motif 3; other site
394221001620	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
394221001621	anticodon binding site; other site
394221001622	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
394221001623	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
394221001624	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
394221001625	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221001626	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221001627	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221001628	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
394221001629	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
394221001630	ring oligomerisation interface [polypeptide binding]; other site
394221001631	ATP/Mg binding site [chemical binding]; other site
394221001632	stacking interactions; other site
394221001633	hinge regions; other site
394221001634	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
394221001635	oligomerisation interface [polypeptide binding]; other site
394221001636	mobile loop; other site
394221001637	roof hairpin; other site
394221001638	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
394221001639	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
394221001640	ligand binding site [chemical binding]; other site
394221001641	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
394221001642	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
394221001643	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
394221001644	active site
394221001645	motif I; other site
394221001646	motif II; other site
394221001647	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
394221001648	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
394221001649	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
394221001650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221001651	active site
394221001652	phosphorylation site [posttranslational modification]
394221001653	intermolecular recognition site; other site
394221001654	dimerization interface [polypeptide binding]; other site
394221001655	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
394221001656	dimer interaction site [polypeptide binding]; other site
394221001657	substrate-binding tunnel; other site
394221001658	active site
394221001659	catalytic site [active]
394221001660	substrate binding site [chemical binding]; other site
394221001661	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
394221001662	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
394221001663	active site
394221001664	Riboflavin kinase; Region: Flavokinase; smart00904
394221001665	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
394221001666	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
394221001667	active site
394221001668	HIGH motif; other site
394221001669	nucleotide binding site [chemical binding]; other site
394221001670	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
394221001671	active site
394221001672	KMSKS motif; other site
394221001673	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
394221001674	tRNA binding surface [nucleotide binding]; other site
394221001675	anticodon binding site; other site
394221001676	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
394221001677	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
394221001678	lipoprotein signal peptidase; Provisional; Region: PRK14787
394221001679	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
394221001680	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
394221001681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221001682	ATP binding site [chemical binding]; other site
394221001683	Mg2+ binding site [ion binding]; other site
394221001684	G-X-G motif; other site
394221001685	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
394221001686	ATP binding site [chemical binding]; other site
394221001687	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
394221001688	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
394221001689	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221001690	S-adenosylmethionine binding site [chemical binding]; other site
394221001691	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
394221001692	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
394221001693	RNA binding surface [nucleotide binding]; other site
394221001694	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
394221001695	active site
394221001696	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
394221001697	nucleoside/Zn binding site; other site
394221001698	dimer interface [polypeptide binding]; other site
394221001699	catalytic motif [active]
394221001700	TfoX N-terminal domain; Region: TfoX_N; cl17592
394221001701	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221001702	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
394221001703	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
394221001704	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
394221001705	Phosphotransferase enzyme family; Region: APH; pfam01636
394221001706	putative active site [active]
394221001707	putative substrate binding site [chemical binding]; other site
394221001708	ATP binding site [chemical binding]; other site
394221001709	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
394221001710	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221001711	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
394221001712	active site
394221001713	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
394221001714	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
394221001715	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
394221001716	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
394221001717	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
394221001718	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
394221001719	generic binding surface I; other site
394221001720	generic binding surface II; other site
394221001721	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
394221001722	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
394221001723	Peptidase family M23; Region: Peptidase_M23; pfam01551
394221001724	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
394221001725	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
394221001726	putative acyl-acceptor binding pocket; other site
394221001727	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
394221001728	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
394221001729	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
394221001730	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
394221001731	putative acyl-acceptor binding pocket; other site
394221001732	Putative phosphatase (DUF442); Region: DUF442; cl17385
394221001733	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221001734	PAS fold; Region: PAS_3; pfam08447
394221001735	putative active site [active]
394221001736	heme pocket [chemical binding]; other site
394221001737	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221001738	dimer interface [polypeptide binding]; other site
394221001739	phosphorylation site [posttranslational modification]
394221001740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221001741	ATP binding site [chemical binding]; other site
394221001742	Mg2+ binding site [ion binding]; other site
394221001743	G-X-G motif; other site
394221001744	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
394221001745	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
394221001746	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221001747	Walker A/P-loop; other site
394221001748	ATP binding site [chemical binding]; other site
394221001749	Q-loop/lid; other site
394221001750	ABC transporter signature motif; other site
394221001751	Walker B; other site
394221001752	D-loop; other site
394221001753	H-loop/switch region; other site
394221001754	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
394221001755	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
394221001756	MAPEG family; Region: MAPEG; cl09190
394221001757	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
394221001758	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
394221001759	catalytic residues [active]
394221001760	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
394221001761	aminotransferase; Validated; Region: PRK09148
394221001762	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
394221001763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221001764	homodimer interface [polypeptide binding]; other site
394221001765	catalytic residue [active]
394221001766	MAPEG family; Region: MAPEG; pfam01124
394221001767	peptide chain release factor 1; Validated; Region: prfA; PRK00591
394221001768	This domain is found in peptide chain release factors; Region: PCRF; smart00937
394221001769	RF-1 domain; Region: RF-1; pfam00472
394221001770	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
394221001771	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221001772	S-adenosylmethionine binding site [chemical binding]; other site
394221001773	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
394221001774	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
394221001775	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
394221001776	MOSC domain; Region: MOSC; pfam03473
394221001777	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
394221001778	Clp amino terminal domain; Region: Clp_N; pfam02861
394221001779	Clp amino terminal domain; Region: Clp_N; pfam02861
394221001780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221001781	Walker A motif; other site
394221001782	ATP binding site [chemical binding]; other site
394221001783	Walker B motif; other site
394221001784	arginine finger; other site
394221001785	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221001786	Walker A motif; other site
394221001787	ATP binding site [chemical binding]; other site
394221001788	Walker B motif; other site
394221001789	arginine finger; other site
394221001790	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
394221001791	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
394221001792	Sodium Bile acid symporter family; Region: SBF; cl17470
394221001793	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
394221001794	Low molecular weight phosphatase family; Region: LMWPc; cl00105
394221001795	active site
394221001796	putative peptidase; Provisional; Region: PRK11649
394221001797	Peptidase family M23; Region: Peptidase_M23; pfam01551
394221001798	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
394221001799	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
394221001800	putative binding surface; other site
394221001801	active site
394221001802	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
394221001803	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
394221001804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221001805	ATP binding site [chemical binding]; other site
394221001806	Mg2+ binding site [ion binding]; other site
394221001807	G-X-G motif; other site
394221001808	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
394221001809	CheW-like domain; Region: CheW; pfam01584
394221001810	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221001811	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
394221001812	putative CheA interaction surface; other site
394221001813	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221001814	Response regulator receiver domain; Region: Response_reg; pfam00072
394221001815	active site
394221001816	phosphorylation site [posttranslational modification]
394221001817	intermolecular recognition site; other site
394221001818	dimerization interface [polypeptide binding]; other site
394221001819	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
394221001820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221001821	active site
394221001822	phosphorylation site [posttranslational modification]
394221001823	intermolecular recognition site; other site
394221001824	dimerization interface [polypeptide binding]; other site
394221001825	CheB methylesterase; Region: CheB_methylest; pfam01339
394221001826	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
394221001827	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
394221001828	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
394221001829	Helix-turn-helix domain; Region: HTH_18; pfam12833
394221001830	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
394221001831	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
394221001832	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
394221001833	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
394221001834	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221001835	active site
394221001836	phosphorylation site [posttranslational modification]
394221001837	intermolecular recognition site; other site
394221001838	dimerization interface [polypeptide binding]; other site
394221001839	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
394221001840	DNA binding site [nucleotide binding]
394221001841	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
394221001842	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
394221001843	Walker A motif/ATP binding site; other site
394221001844	Walker B motif; other site
394221001845	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
394221001846	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
394221001847	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221001848	Transcriptional regulator [Transcription]; Region: LysR; COG0583
394221001849	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
394221001850	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
394221001851	substrate binding pocket [chemical binding]; other site
394221001852	dimerization interface [polypeptide binding]; other site
394221001853	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
394221001854	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
394221001855	Protein export membrane protein; Region: SecD_SecF; cl14618
394221001856	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
394221001857	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
394221001858	P-loop; other site
394221001859	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
394221001860	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
394221001861	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
394221001862	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
394221001863	FHIPEP family; Region: FHIPEP; pfam00771
394221001864	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
394221001865	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221001866	Walker A motif; other site
394221001867	ATP binding site [chemical binding]; other site
394221001868	Walker B motif; other site
394221001869	arginine finger; other site
394221001870	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
394221001871	flagellar motor switch protein; Reviewed; Region: PRK08916
394221001872	flagellar assembly protein H; Validated; Region: fliH; PRK06032
394221001873	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
394221001874	FliG C-terminal domain; Region: FliG_C; pfam01706
394221001875	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
394221001876	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
394221001877	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
394221001878	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
394221001879	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
394221001880	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
394221001881	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
394221001882	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
394221001883	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
394221001884	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
394221001885	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
394221001886	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
394221001887	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
394221001888	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
394221001889	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
394221001890	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
394221001891	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
394221001892	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
394221001893	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
394221001894	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
394221001895	Ligand Binding Site [chemical binding]; other site
394221001896	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
394221001897	Sel1 repeat; Region: Sel1; cl02723
394221001898	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
394221001899	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
394221001900	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
394221001901	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
394221001902	dimer interface [polypeptide binding]; other site
394221001903	active site
394221001904	Predicted transcriptional regulator [Transcription]; Region: COG3905
394221001905	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
394221001906	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221001907	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221001908	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
394221001909	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221001910	putative DNA binding site [nucleotide binding]; other site
394221001911	putative Zn2+ binding site [ion binding]; other site
394221001912	AsnC family; Region: AsnC_trans_reg; pfam01037
394221001913	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
394221001914	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
394221001915	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
394221001916	tetramer interface [polypeptide binding]; other site
394221001917	TPP-binding site [chemical binding]; other site
394221001918	heterodimer interface [polypeptide binding]; other site
394221001919	phosphorylation loop region [posttranslational modification]
394221001920	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
394221001921	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
394221001922	alpha subunit interface [polypeptide binding]; other site
394221001923	TPP binding site [chemical binding]; other site
394221001924	heterodimer interface [polypeptide binding]; other site
394221001925	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
394221001926	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
394221001927	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
394221001928	E3 interaction surface; other site
394221001929	lipoyl attachment site [posttranslational modification]; other site
394221001930	e3 binding domain; Region: E3_binding; pfam02817
394221001931	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
394221001932	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
394221001933	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
394221001934	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
394221001935	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
394221001936	active site
394221001937	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
394221001938	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
394221001939	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
394221001940	dimerization interface [polypeptide binding]; other site
394221001941	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
394221001942	dimer interface [polypeptide binding]; other site
394221001943	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
394221001944	putative CheW interface [polypeptide binding]; other site
394221001945	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
394221001946	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221001947	dimer interface [polypeptide binding]; other site
394221001948	phosphorylation site [posttranslational modification]
394221001949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221001950	ATP binding site [chemical binding]; other site
394221001951	Mg2+ binding site [ion binding]; other site
394221001952	G-X-G motif; other site
394221001953	Response regulator receiver domain; Region: Response_reg; pfam00072
394221001954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221001955	active site
394221001956	phosphorylation site [posttranslational modification]
394221001957	intermolecular recognition site; other site
394221001958	dimerization interface [polypeptide binding]; other site
394221001959	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
394221001960	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
394221001961	Ligand Binding Site [chemical binding]; other site
394221001962	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
394221001963	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
394221001964	FeS/SAM binding site; other site
394221001965	Protein of unknown function (DUF1355); Region: DUF1355; pfam07090
394221001966	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
394221001967	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
394221001968	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
394221001969	Protein of unknown function DUF58; Region: DUF58; pfam01882
394221001970	MoxR-like ATPases [General function prediction only]; Region: COG0714
394221001971	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221001972	Walker A motif; other site
394221001973	ATP binding site [chemical binding]; other site
394221001974	Walker B motif; other site
394221001975	arginine finger; other site
394221001976	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
394221001977	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
394221001978	putative active site [active]
394221001979	putative CoA binding site [chemical binding]; other site
394221001980	nudix motif; other site
394221001981	metal binding site [ion binding]; metal-binding site
394221001982	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
394221001983	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
394221001984	active site
394221001985	NTP binding site [chemical binding]; other site
394221001986	metal binding triad [ion binding]; metal-binding site
394221001987	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
394221001988	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
394221001989	Active site serine [active]
394221001990	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
394221001991	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
394221001992	conserved cys residue [active]
394221001993	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
394221001994	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
394221001995	CAAX protease self-immunity; Region: Abi; pfam02517
394221001996	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
394221001997	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
394221001998	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
394221001999	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
394221002000	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
394221002001	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
394221002002	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
394221002003	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
394221002004	[2Fe-2S] cluster binding site [ion binding]; other site
394221002005	cytochrome b; Provisional; Region: CYTB; MTH00145
394221002006	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
394221002007	Qi binding site; other site
394221002008	intrachain domain interface; other site
394221002009	interchain domain interface [polypeptide binding]; other site
394221002010	heme bH binding site [chemical binding]; other site
394221002011	heme bL binding site [chemical binding]; other site
394221002012	Qo binding site; other site
394221002013	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
394221002014	interchain domain interface [polypeptide binding]; other site
394221002015	intrachain domain interface; other site
394221002016	Qi binding site; other site
394221002017	Qo binding site; other site
394221002018	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
394221002019	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
394221002020	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
394221002021	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
394221002022	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
394221002023	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
394221002024	putative C-terminal domain interface [polypeptide binding]; other site
394221002025	putative GSH binding site (G-site) [chemical binding]; other site
394221002026	putative dimer interface [polypeptide binding]; other site
394221002027	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
394221002028	putative N-terminal domain interface [polypeptide binding]; other site
394221002029	putative dimer interface [polypeptide binding]; other site
394221002030	putative substrate binding pocket (H-site) [chemical binding]; other site
394221002031	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
394221002032	active site
394221002033	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
394221002034	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
394221002035	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
394221002036	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
394221002037	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
394221002038	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
394221002039	Walker A/P-loop; other site
394221002040	ATP binding site [chemical binding]; other site
394221002041	Q-loop/lid; other site
394221002042	ABC transporter signature motif; other site
394221002043	Walker B; other site
394221002044	D-loop; other site
394221002045	H-loop/switch region; other site
394221002046	ABC-2 type transporter; Region: ABC2_membrane; cl17235
394221002047	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
394221002048	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
394221002049	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
394221002050	enoyl-CoA hydratase; Provisional; Region: PRK08260
394221002051	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
394221002052	substrate binding site [chemical binding]; other site
394221002053	oxyanion hole (OAH) forming residues; other site
394221002054	trimer interface [polypeptide binding]; other site
394221002055	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
394221002056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221002057	putative substrate translocation pore; other site
394221002058	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
394221002059	apolar tunnel; other site
394221002060	heme binding site [chemical binding]; other site
394221002061	dimerization interface [polypeptide binding]; other site
394221002062	GTP-binding protein YchF; Reviewed; Region: PRK09601
394221002063	YchF GTPase; Region: YchF; cd01900
394221002064	G1 box; other site
394221002065	GTP/Mg2+ binding site [chemical binding]; other site
394221002066	Switch I region; other site
394221002067	G2 box; other site
394221002068	Switch II region; other site
394221002069	G3 box; other site
394221002070	G4 box; other site
394221002071	G5 box; other site
394221002072	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
394221002073	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
394221002074	putative active site [active]
394221002075	catalytic residue [active]
394221002076	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
394221002077	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
394221002078	5S rRNA interface [nucleotide binding]; other site
394221002079	CTC domain interface [polypeptide binding]; other site
394221002080	L16 interface [polypeptide binding]; other site
394221002081	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
394221002082	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
394221002083	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
394221002084	active site
394221002085	Uncharacterized conserved protein [Function unknown]; Region: COG1565
394221002086	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
394221002087	Membrane fusogenic activity; Region: BMFP; pfam04380
394221002088	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
394221002089	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
394221002090	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
394221002091	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
394221002092	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
394221002093	dimerization interface [polypeptide binding]; other site
394221002094	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221002095	dimer interface [polypeptide binding]; other site
394221002096	phosphorylation site [posttranslational modification]
394221002097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221002098	ATP binding site [chemical binding]; other site
394221002099	Mg2+ binding site [ion binding]; other site
394221002100	G-X-G motif; other site
394221002101	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
394221002102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221002103	active site
394221002104	phosphorylation site [posttranslational modification]
394221002105	intermolecular recognition site; other site
394221002106	dimerization interface [polypeptide binding]; other site
394221002107	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
394221002108	DNA binding site [nucleotide binding]
394221002109	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
394221002110	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
394221002111	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
394221002112	active site
394221002113	motif I; other site
394221002114	motif II; other site
394221002115	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
394221002116	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
394221002117	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
394221002118	GIY-YIG motif/motif A; other site
394221002119	active site
394221002120	catalytic site [active]
394221002121	putative DNA binding site [nucleotide binding]; other site
394221002122	metal binding site [ion binding]; metal-binding site
394221002123	UvrB/uvrC motif; Region: UVR; pfam02151
394221002124	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
394221002125	short chain dehydrogenase; Provisional; Region: PRK09134
394221002126	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221002127	NAD(P) binding site [chemical binding]; other site
394221002128	active site
394221002129	Dihydroneopterin aldolase; Region: FolB; smart00905
394221002130	active site
394221002131	Predicted membrane protein [Function unknown]; Region: COG2311
394221002132	Protein of unknown function (DUF418); Region: DUF418; cl12135
394221002133	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
394221002134	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221002135	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221002136	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
394221002137	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
394221002138	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
394221002139	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
394221002140	nudix motif; other site
394221002141	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
394221002142	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221002143	putative active site [active]
394221002144	heme pocket [chemical binding]; other site
394221002145	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221002146	dimer interface [polypeptide binding]; other site
394221002147	phosphorylation site [posttranslational modification]
394221002148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221002149	ATP binding site [chemical binding]; other site
394221002150	G-X-G motif; other site
394221002151	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221002152	dimer interface [polypeptide binding]; other site
394221002153	phosphorylation site [posttranslational modification]
394221002154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221002155	ATP binding site [chemical binding]; other site
394221002156	Mg2+ binding site [ion binding]; other site
394221002157	G-X-G motif; other site
394221002158	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221002159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221002160	active site
394221002161	phosphorylation site [posttranslational modification]
394221002162	intermolecular recognition site; other site
394221002163	dimerization interface [polypeptide binding]; other site
394221002164	Putative esterase; Region: Esterase; pfam00756
394221002165	Predicted esterase [General function prediction only]; Region: COG0627
394221002166	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
394221002167	active site
394221002168	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
394221002169	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
394221002170	dimerization interface [polypeptide binding]; other site
394221002171	active site
394221002172	L-aspartate oxidase; Provisional; Region: PRK07512
394221002173	L-aspartate oxidase; Provisional; Region: PRK06175
394221002174	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
394221002175	quinolinate synthetase; Provisional; Region: PRK09375
394221002176	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
394221002177	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
394221002178	active site
394221002179	Killing trait; Region: RebB; pfam11747
394221002180	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
394221002181	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
394221002182	translocation protein TolB; Provisional; Region: tolB; PRK02889
394221002183	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
394221002184	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
394221002185	dimer interface [polypeptide binding]; other site
394221002186	active site
394221002187	CoA binding pocket [chemical binding]; other site
394221002188	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
394221002189	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221002190	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221002191	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
394221002192	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
394221002193	dimer interface [polypeptide binding]; other site
394221002194	active site
394221002195	CoA binding pocket [chemical binding]; other site
394221002196	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
394221002197	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
394221002198	substrate binding site [chemical binding]; other site
394221002199	catalytic Zn binding site [ion binding]; other site
394221002200	NAD binding site [chemical binding]; other site
394221002201	structural Zn binding site [ion binding]; other site
394221002202	dimer interface [polypeptide binding]; other site
394221002203	hypothetical protein; Provisional; Region: PRK07908
394221002204	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
394221002205	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
394221002206	putative active site [active]
394221002207	homotetrameric interface [polypeptide binding]; other site
394221002208	metal binding site [ion binding]; metal-binding site
394221002209	S-formylglutathione hydrolase; Region: PLN02442
394221002210	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
394221002211	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
394221002212	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
394221002213	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221002214	PAS domain; Region: PAS_9; pfam13426
394221002215	putative active site [active]
394221002216	heme pocket [chemical binding]; other site
394221002217	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221002218	PAS domain; Region: PAS_9; pfam13426
394221002219	putative active site [active]
394221002220	heme pocket [chemical binding]; other site
394221002221	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
394221002222	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
394221002223	dimer interface [polypeptide binding]; other site
394221002224	putative CheW interface [polypeptide binding]; other site
394221002225	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
394221002226	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
394221002227	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
394221002228	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
394221002229	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
394221002230	putative active site [active]
394221002231	dihydroorotase; Validated; Region: PRK09060
394221002232	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221002233	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
394221002234	active site
394221002235	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
394221002236	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
394221002237	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
394221002238	FtsX-like permease family; Region: FtsX; pfam02687
394221002239	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
394221002240	FtsX-like permease family; Region: FtsX; pfam02687
394221002241	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
394221002242	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
394221002243	Walker A/P-loop; other site
394221002244	ATP binding site [chemical binding]; other site
394221002245	Q-loop/lid; other site
394221002246	ABC transporter signature motif; other site
394221002247	Walker B; other site
394221002248	D-loop; other site
394221002249	H-loop/switch region; other site
394221002250	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
394221002251	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221002252	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221002253	non-specific DNA binding site [nucleotide binding]; other site
394221002254	salt bridge; other site
394221002255	sequence-specific DNA binding site [nucleotide binding]; other site
394221002256	Protein of unknown function (DUF2385); Region: DUF2385; pfam09539
394221002257	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
394221002258	nudix motif; other site
394221002259	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221002260	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
394221002261	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221002262	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
394221002263	NAD(P) binding site [chemical binding]; other site
394221002264	active site
394221002265	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
394221002266	GIY-YIG motif/motif A; other site
394221002267	putative active site [active]
394221002268	putative metal binding site [ion binding]; other site
394221002269	Protein of unknown function (DUF328); Region: DUF328; pfam03883
394221002270	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
394221002271	putative active site [active]
394221002272	putative catalytic site [active]
394221002273	putative Mg binding site IVb [ion binding]; other site
394221002274	putative phosphate binding site [ion binding]; other site
394221002275	putative DNA binding site [nucleotide binding]; other site
394221002276	putative Mg binding site IVa [ion binding]; other site
394221002277	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
394221002278	FAD binding domain; Region: FAD_binding_4; pfam01565
394221002279	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
394221002280	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
394221002281	YceI-like domain; Region: YceI; pfam04264
394221002282	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
394221002283	Uncharacterized conserved protein [Function unknown]; Region: COG2353
394221002284	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
394221002285	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
394221002286	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
394221002287	active site
394221002288	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
394221002289	Predicted membrane protein [Function unknown]; Region: COG3671
394221002290	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
394221002291	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
394221002292	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
394221002293	Catalytic site [active]
394221002294	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
394221002295	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
394221002296	Catalytic site [active]
394221002297	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
394221002298	short chain dehydrogenase; Provisional; Region: PRK08278
394221002299	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221002300	NAD(P) binding site [chemical binding]; other site
394221002301	active site
394221002302	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
394221002303	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
394221002304	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
394221002305	SET domain; Region: SET; pfam00856
394221002306	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
394221002307	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
394221002308	putative active site [active]
394221002309	Zn binding site [ion binding]; other site
394221002310	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
394221002311	catalytic core [active]
394221002312	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
394221002313	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
394221002314	dimer interface [polypeptide binding]; other site
394221002315	putative tRNA-binding site [nucleotide binding]; other site
394221002316	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
394221002317	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
394221002318	substrate binding pocket [chemical binding]; other site
394221002319	chain length determination region; other site
394221002320	substrate-Mg2+ binding site; other site
394221002321	catalytic residues [active]
394221002322	aspartate-rich region 1; other site
394221002323	active site lid residues [active]
394221002324	aspartate-rich region 2; other site
394221002325	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
394221002326	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
394221002327	TPP-binding site; other site
394221002328	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
394221002329	PYR/PP interface [polypeptide binding]; other site
394221002330	dimer interface [polypeptide binding]; other site
394221002331	TPP binding site [chemical binding]; other site
394221002332	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
394221002333	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
394221002334	Ligand Binding Site [chemical binding]; other site
394221002335	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
394221002336	Ligand Binding Site [chemical binding]; other site
394221002337	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
394221002338	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
394221002339	Sulfate transporter family; Region: Sulfate_transp; pfam00916
394221002340	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
394221002341	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
394221002342	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
394221002343	RNA binding surface [nucleotide binding]; other site
394221002344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221002345	S-adenosylmethionine binding site [chemical binding]; other site
394221002346	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
394221002347	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
394221002348	Tetramer interface [polypeptide binding]; other site
394221002349	active site
394221002350	FMN-binding site [chemical binding]; other site
394221002351	chaperone protein DnaJ; Provisional; Region: PRK14299
394221002352	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
394221002353	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
394221002354	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
394221002355	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
394221002356	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
394221002357	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
394221002358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
394221002359	dimer interface [polypeptide binding]; other site
394221002360	conserved gate region; other site
394221002361	putative PBP binding loops; other site
394221002362	ABC-ATPase subunit interface; other site
394221002363	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
394221002364	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
394221002365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
394221002366	dimer interface [polypeptide binding]; other site
394221002367	conserved gate region; other site
394221002368	putative PBP binding loops; other site
394221002369	ABC-ATPase subunit interface; other site
394221002370	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
394221002371	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
394221002372	peptide binding site [polypeptide binding]; other site
394221002373	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
394221002374	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
394221002375	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
394221002376	tandem repeat interface [polypeptide binding]; other site
394221002377	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
394221002378	oligomer interface [polypeptide binding]; other site
394221002379	active site residues [active]
394221002380	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
394221002381	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
394221002382	tandem repeat interface [polypeptide binding]; other site
394221002383	oligomer interface [polypeptide binding]; other site
394221002384	active site residues [active]
394221002385	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
394221002386	Tup N-terminal; Region: Tup_N; pfam08581
394221002387	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
394221002388	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
394221002389	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
394221002390	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
394221002391	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
394221002392	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
394221002393	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
394221002394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221002395	TPR motif; other site
394221002396	binding surface
394221002397	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221002398	binding surface
394221002399	TPR motif; other site
394221002400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
394221002401	TPR motif; other site
394221002402	binding surface
394221002403	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
394221002404	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
394221002405	GIY-YIG motif/motif A; other site
394221002406	putative active site [active]
394221002407	putative metal binding site [ion binding]; other site
394221002408	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
394221002409	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221002410	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
394221002411	SelR domain; Region: SelR; pfam01641
394221002412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221002413	putative substrate translocation pore; other site
394221002414	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
394221002415	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
394221002416	GIY-YIG motif/motif A; other site
394221002417	putative active site [active]
394221002418	putative metal binding site [ion binding]; other site
394221002419	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
394221002420	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
394221002421	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
394221002422	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12504
394221002423	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
394221002424	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
394221002425	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12508
394221002426	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
394221002427	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
394221002428	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
394221002429	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
394221002430	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
394221002431	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
394221002432	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668
394221002433	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
394221002434	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
394221002435	DnaA box-binding interface [nucleotide binding]; other site
394221002436	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
394221002437	PAS domain; Region: PAS; smart00091
394221002438	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
394221002439	putative active site [active]
394221002440	heme pocket [chemical binding]; other site
394221002441	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221002442	dimer interface [polypeptide binding]; other site
394221002443	phosphorylation site [posttranslational modification]
394221002444	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221002445	ATP binding site [chemical binding]; other site
394221002446	Mg2+ binding site [ion binding]; other site
394221002447	G-X-G motif; other site
394221002448	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
394221002449	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
394221002450	ATP binding site [chemical binding]; other site
394221002451	Mg++ binding site [ion binding]; other site
394221002452	motif III; other site
394221002453	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
394221002454	nucleotide binding region [chemical binding]; other site
394221002455	ATP-binding site [chemical binding]; other site
394221002456	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
394221002457	RNA binding site [nucleotide binding]; other site
394221002458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221002459	intermolecular recognition site; other site
394221002460	active site
394221002461	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221002462	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221002463	dimer interface [polypeptide binding]; other site
394221002464	phosphorylation site [posttranslational modification]
394221002465	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221002466	ATP binding site [chemical binding]; other site
394221002467	Mg2+ binding site [ion binding]; other site
394221002468	G-X-G motif; other site
394221002469	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
394221002470	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221002471	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221002472	dimer interface [polypeptide binding]; other site
394221002473	phosphorylation site [posttranslational modification]
394221002474	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221002475	ATP binding site [chemical binding]; other site
394221002476	Mg2+ binding site [ion binding]; other site
394221002477	G-X-G motif; other site
394221002478	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
394221002479	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221002480	active site
394221002481	phosphorylation site [posttranslational modification]
394221002482	intermolecular recognition site; other site
394221002483	dimerization interface [polypeptide binding]; other site
394221002484	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
394221002485	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
394221002486	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
394221002487	ABC transporter; Region: ABC_tran_2; pfam12848
394221002488	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
394221002489	C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317
394221002490	substrate binding site [chemical binding]; other site
394221002491	Ca binding site [ion binding]; other site
394221002492	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
394221002493	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
394221002494	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
394221002495	G1 box; other site
394221002496	putative GEF interaction site [polypeptide binding]; other site
394221002497	GTP/Mg2+ binding site [chemical binding]; other site
394221002498	Switch I region; other site
394221002499	G2 box; other site
394221002500	G3 box; other site
394221002501	Switch II region; other site
394221002502	G4 box; other site
394221002503	G5 box; other site
394221002504	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
394221002505	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
394221002506	Mechanosensitive ion channel; Region: MS_channel; pfam00924
394221002507	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
394221002508	PAN domain; Region: PAN_4; pfam14295
394221002509	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
394221002510	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
394221002511	metal binding site [ion binding]; metal-binding site
394221002512	active site
394221002513	I-site; other site
394221002514	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
394221002515	Ion transport protein; Region: Ion_trans; pfam00520
394221002516	Transglycosylase; Region: Transgly; pfam00912
394221002517	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
394221002518	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
394221002519	hypothetical protein; Provisional; Region: PRK05170
394221002520	Uncharacterized conserved protein [Function unknown]; Region: COG5323
394221002521	Terminase-like family; Region: Terminase_6; pfam03237
394221002522	Phage-related protein [Function unknown]; Region: COG4695
394221002523	Phage portal protein; Region: Phage_portal; pfam04860
394221002524	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
394221002525	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
394221002526	Phage capsid family; Region: Phage_capsid; pfam05065
394221002527	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
394221002528	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
394221002529	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
394221002530	oligomerization interface [polypeptide binding]; other site
394221002531	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
394221002532	Phage major tail protein 2; Region: Phage_tail_2; cl11463
394221002533	Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550
394221002534	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
394221002535	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
394221002536	Uncharacterized conserved protein [Function unknown]; Region: COG5449
394221002537	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
394221002538	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
394221002539	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
394221002540	NlpC/P60 family; Region: NLPC_P60; cl17555
394221002541	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
394221002542	Putative phage tail protein; Region: Phage-tail_3; pfam13550
394221002543	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
394221002544	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
394221002545	HSP70 interaction site [polypeptide binding]; other site
394221002546	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
394221002547	substrate binding site [polypeptide binding]; other site
394221002548	dimer interface [polypeptide binding]; other site
394221002549	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
394221002550	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
394221002551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221002552	active site
394221002553	phosphorylation site [posttranslational modification]
394221002554	intermolecular recognition site; other site
394221002555	dimerization interface [polypeptide binding]; other site
394221002556	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
394221002557	DNA binding site [nucleotide binding]
394221002558	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
394221002559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221002560	ATP binding site [chemical binding]; other site
394221002561	Mg2+ binding site [ion binding]; other site
394221002562	G-X-G motif; other site
394221002563	Protein of unknown function (DUF938); Region: DUF938; pfam06080
394221002564	Methyltransferase domain; Region: Methyltransf_23; pfam13489
394221002565	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
394221002566	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
394221002567	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
394221002568	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
394221002569	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
394221002570	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
394221002571	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
394221002572	protein binding site [polypeptide binding]; other site
394221002573	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
394221002574	protein binding site [polypeptide binding]; other site
394221002575	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
394221002576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221002577	active site
394221002578	phosphorylation site [posttranslational modification]
394221002579	intermolecular recognition site; other site
394221002580	dimerization interface [polypeptide binding]; other site
394221002581	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
394221002582	DNA binding site [nucleotide binding]
394221002583	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221002584	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
394221002585	dimerization interface [polypeptide binding]; other site
394221002586	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221002587	dimer interface [polypeptide binding]; other site
394221002588	phosphorylation site [posttranslational modification]
394221002589	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221002590	ATP binding site [chemical binding]; other site
394221002591	Mg2+ binding site [ion binding]; other site
394221002592	G-X-G motif; other site
394221002593	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
394221002594	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
394221002595	metal binding triad; other site
394221002596	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
394221002597	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
394221002598	metal binding triad; other site
394221002599	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
394221002600	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
394221002601	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
394221002602	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
394221002603	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
394221002604	DNA binding residues [nucleotide binding]
394221002605	PAS fold; Region: PAS; pfam00989
394221002606	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221002607	putative active site [active]
394221002608	heme pocket [chemical binding]; other site
394221002609	PAS fold; Region: PAS_7; pfam12860
394221002610	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221002611	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221002612	dimer interface [polypeptide binding]; other site
394221002613	phosphorylation site [posttranslational modification]
394221002614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221002615	ATP binding site [chemical binding]; other site
394221002616	Mg2+ binding site [ion binding]; other site
394221002617	G-X-G motif; other site
394221002618	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221002619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221002620	active site
394221002621	phosphorylation site [posttranslational modification]
394221002622	intermolecular recognition site; other site
394221002623	dimerization interface [polypeptide binding]; other site
394221002624	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
394221002625	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
394221002626	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
394221002627	FMN binding site [chemical binding]; other site
394221002628	active site
394221002629	catalytic residues [active]
394221002630	substrate binding site [chemical binding]; other site
394221002631	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
394221002632	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
394221002633	catalytic motif [active]
394221002634	Catalytic residue [active]
394221002635	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
394221002636	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
394221002637	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
394221002638	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
394221002639	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
394221002640	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
394221002641	trimer interface [polypeptide binding]; other site
394221002642	active site
394221002643	substrate binding site [chemical binding]; other site
394221002644	CoA binding site [chemical binding]; other site
394221002645	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
394221002646	CoenzymeA binding site [chemical binding]; other site
394221002647	subunit interaction site [polypeptide binding]; other site
394221002648	PHB binding site; other site
394221002649	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
394221002650	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
394221002651	putative uracil binding site [chemical binding]; other site
394221002652	putative active site [active]
394221002653	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
394221002654	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
394221002655	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
394221002656	NAD binding site [chemical binding]; other site
394221002657	Phe binding site; other site
394221002658	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
394221002659	Mechanosensitive ion channel; Region: MS_channel; pfam00924
394221002660	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
394221002661	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
394221002662	Walker A/P-loop; other site
394221002663	ATP binding site [chemical binding]; other site
394221002664	Q-loop/lid; other site
394221002665	ABC transporter signature motif; other site
394221002666	Walker B; other site
394221002667	D-loop; other site
394221002668	H-loop/switch region; other site
394221002669	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
394221002670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
394221002671	ABC-ATPase subunit interface; other site
394221002672	putative PBP binding loops; other site
394221002673	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
394221002674	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
394221002675	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
394221002676	phosphoglycolate phosphatase; Provisional; Region: PRK13222
394221002677	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
394221002678	motif II; other site
394221002679	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
394221002680	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
394221002681	Substrate binding site; other site
394221002682	Mg++ binding site; other site
394221002683	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
394221002684	active site
394221002685	substrate binding site [chemical binding]; other site
394221002686	CoA binding site [chemical binding]; other site
394221002687	succinic semialdehyde dehydrogenase; Region: PLN02278
394221002688	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
394221002689	tetramerization interface [polypeptide binding]; other site
394221002690	NAD(P) binding site [chemical binding]; other site
394221002691	catalytic residues [active]
394221002692	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
394221002693	tetramer (dimer of dimers) interface [polypeptide binding]; other site
394221002694	active site
394221002695	dimer interface [polypeptide binding]; other site
394221002696	glutathione reductase; Validated; Region: PRK06116
394221002697	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
394221002698	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
394221002699	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
394221002700	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
394221002701	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
394221002702	IHF - DNA interface [nucleotide binding]; other site
394221002703	IHF dimer interface [polypeptide binding]; other site
394221002704	Response regulator receiver domain; Region: Response_reg; pfam00072
394221002705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221002706	active site
394221002707	phosphorylation site [posttranslational modification]
394221002708	intermolecular recognition site; other site
394221002709	dimerization interface [polypeptide binding]; other site
394221002710	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
394221002711	GAF domain; Region: GAF; cl17456
394221002712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221002713	dimer interface [polypeptide binding]; other site
394221002714	phosphorylation site [posttranslational modification]
394221002715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221002716	ATP binding site [chemical binding]; other site
394221002717	Mg2+ binding site [ion binding]; other site
394221002718	G-X-G motif; other site
394221002719	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
394221002720	Prostaglandin dehydrogenases; Region: PGDH; cd05288
394221002721	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
394221002722	NAD(P) binding site [chemical binding]; other site
394221002723	substrate binding site [chemical binding]; other site
394221002724	dimer interface [polypeptide binding]; other site
394221002725	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
394221002726	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
394221002727	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
394221002728	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
394221002729	NAD synthetase; Provisional; Region: PRK13981
394221002730	multimer interface [polypeptide binding]; other site
394221002731	active site
394221002732	catalytic triad [active]
394221002733	protein interface 1 [polypeptide binding]; other site
394221002734	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
394221002735	homodimer interface [polypeptide binding]; other site
394221002736	NAD binding pocket [chemical binding]; other site
394221002737	ATP binding pocket [chemical binding]; other site
394221002738	Mg binding site [ion binding]; other site
394221002739	active-site loop [active]
394221002740	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
394221002741	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
394221002742	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
394221002743	active site
394221002744	HIGH motif; other site
394221002745	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
394221002746	active site
394221002747	KMSKS motif; other site
394221002748	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
394221002749	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
394221002750	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221002751	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221002752	non-specific DNA binding site [nucleotide binding]; other site
394221002753	salt bridge; other site
394221002754	sequence-specific DNA binding site [nucleotide binding]; other site
394221002755	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
394221002756	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
394221002757	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
394221002758	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
394221002759	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221002760	Walker A/P-loop; other site
394221002761	ATP binding site [chemical binding]; other site
394221002762	Q-loop/lid; other site
394221002763	ABC transporter signature motif; other site
394221002764	Walker B; other site
394221002765	D-loop; other site
394221002766	H-loop/switch region; other site
394221002767	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
394221002768	arogenate dehydrogenase; Region: PLN02256
394221002769	Protein of unknown function (DUF962); Region: DUF962; pfam06127
394221002770	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
394221002771	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
394221002772	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
394221002773	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221002774	NAD(P) binding site [chemical binding]; other site
394221002775	active site
394221002776	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
394221002777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221002778	S-adenosylmethionine binding site [chemical binding]; other site
394221002779	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
394221002780	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
394221002781	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
394221002782	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
394221002783	substrate binding pocket [chemical binding]; other site
394221002784	membrane-bound complex binding site; other site
394221002785	hinge residues; other site
394221002786	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
394221002787	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
394221002788	N-acetyl-D-glucosamine binding site [chemical binding]; other site
394221002789	catalytic residue [active]
394221002790	recombinase A; Provisional; Region: recA; PRK09354
394221002791	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
394221002792	hexamer interface [polypeptide binding]; other site
394221002793	Walker A motif; other site
394221002794	ATP binding site [chemical binding]; other site
394221002795	Walker B motif; other site
394221002796	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
394221002797	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
394221002798	motif 1; other site
394221002799	active site
394221002800	motif 2; other site
394221002801	motif 3; other site
394221002802	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
394221002803	SnoaL-like domain; Region: SnoaL_4; cl17707
394221002804	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
394221002805	isocitrate dehydrogenase; Validated; Region: PRK08299
394221002806	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
394221002807	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
394221002808	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221002809	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221002810	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
394221002811	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
394221002812	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
394221002813	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
394221002814	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
394221002815	RNA binding surface [nucleotide binding]; other site
394221002816	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
394221002817	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
394221002818	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
394221002819	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
394221002820	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
394221002821	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
394221002822	active site
394221002823	homotetramer interface [polypeptide binding]; other site
394221002824	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
394221002825	putative GSH binding site [chemical binding]; other site
394221002826	catalytic residues [active]
394221002827	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
394221002828	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
394221002829	active site
394221002830	catalytic tetrad [active]
394221002831	BolA-like protein; Region: BolA; pfam01722
394221002832	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
394221002833	M28 Zn-Peptidases; Region: M28_like_2; cd05662
394221002834	Peptidase family M28; Region: Peptidase_M28; pfam04389
394221002835	metal binding site [ion binding]; metal-binding site
394221002836	Phospholipid methyltransferase; Region: PEMT; pfam04191
394221002837	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
394221002838	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
394221002839	dimerization interface [polypeptide binding]; other site
394221002840	ATP binding site [chemical binding]; other site
394221002841	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
394221002842	dimerization interface [polypeptide binding]; other site
394221002843	ATP binding site [chemical binding]; other site
394221002844	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
394221002845	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
394221002846	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
394221002847	putative active site [active]
394221002848	catalytic triad [active]
394221002849	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
394221002850	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
394221002851	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
394221002852	ATP binding site [chemical binding]; other site
394221002853	active site
394221002854	substrate binding site [chemical binding]; other site
394221002855	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
394221002856	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
394221002857	catalytic residues [active]
394221002858	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
394221002859	adenylosuccinate lyase; Provisional; Region: PRK07492
394221002860	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
394221002861	tetramer interface [polypeptide binding]; other site
394221002862	active site
394221002863	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
394221002864	putative active site [active]
394221002865	threonine synthase; Validated; Region: PRK08197
394221002866	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
394221002867	homodimer interface [polypeptide binding]; other site
394221002868	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221002869	catalytic residue [active]
394221002870	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
394221002871	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
394221002872	active site
394221002873	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
394221002874	active site
394221002875	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221002876	hypothetical protein; Reviewed; Region: PRK00024
394221002877	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
394221002878	MPN+ (JAMM) motif; other site
394221002879	Zinc-binding site [ion binding]; other site
394221002880	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
394221002881	active site
394221002882	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
394221002883	PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820
394221002884	PA/protease or protease-like domain interface [polypeptide binding]; other site
394221002885	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661
394221002886	Peptidase family M28; Region: Peptidase_M28; pfam04389
394221002887	metal binding site [ion binding]; metal-binding site
394221002888	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
394221002889	active site
394221002890	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
394221002891	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
394221002892	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
394221002893	putative MPT binding site; other site
394221002894	von Willebrand factor; Region: vWF_A; pfam12450
394221002895	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
394221002896	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
394221002897	metal ion-dependent adhesion site (MIDAS); other site
394221002898	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
394221002899	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221002900	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221002901	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221002902	binding surface
394221002903	TPR motif; other site
394221002904	TPR repeat; Region: TPR_11; pfam13414
394221002905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221002906	TPR motif; other site
394221002907	binding surface
394221002908	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
394221002909	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
394221002910	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
394221002911	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221002912	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
394221002913	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
394221002914	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
394221002915	endonuclease III; Region: ENDO3c; smart00478
394221002916	minor groove reading motif; other site
394221002917	helix-hairpin-helix signature motif; other site
394221002918	substrate binding pocket [chemical binding]; other site
394221002919	active site
394221002920	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
394221002921	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
394221002922	FMN binding site [chemical binding]; other site
394221002923	substrate binding site [chemical binding]; other site
394221002924	putative catalytic residue [active]
394221002925	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
394221002926	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
394221002927	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
394221002928	motif II; other site
394221002929	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
394221002930	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
394221002931	hexamer interface [polypeptide binding]; other site
394221002932	ligand binding site [chemical binding]; other site
394221002933	putative active site [active]
394221002934	NAD(P) binding site [chemical binding]; other site
394221002935	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
394221002936	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221002937	putative DNA binding site [nucleotide binding]; other site
394221002938	putative Zn2+ binding site [ion binding]; other site
394221002939	AsnC family; Region: AsnC_trans_reg; pfam01037
394221002940	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
394221002941	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
394221002942	putative FMN binding site [chemical binding]; other site
394221002943	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221002944	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221002945	WHG domain; Region: WHG; pfam13305
394221002946	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
394221002947	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221002948	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
394221002949	Protein export membrane protein; Region: SecD_SecF; cl14618
394221002950	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
394221002951	ADP-ribose binding site [chemical binding]; other site
394221002952	dimer interface [polypeptide binding]; other site
394221002953	active site
394221002954	nudix motif; other site
394221002955	metal binding site [ion binding]; metal-binding site
394221002956	serine acetyltransferase; Provisional; Region: cysE; PRK11132
394221002957	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
394221002958	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
394221002959	trimer interface [polypeptide binding]; other site
394221002960	active site
394221002961	substrate binding site [chemical binding]; other site
394221002962	CoA binding site [chemical binding]; other site
394221002963	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
394221002964	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
394221002965	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221002966	Walker A/P-loop; other site
394221002967	ATP binding site [chemical binding]; other site
394221002968	Q-loop/lid; other site
394221002969	ABC transporter signature motif; other site
394221002970	Walker B; other site
394221002971	D-loop; other site
394221002972	H-loop/switch region; other site
394221002973	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
394221002974	dimer interface [polypeptide binding]; other site
394221002975	conserved gate region; other site
394221002976	putative PBP binding loops; other site
394221002977	ABC-ATPase subunit interface; other site
394221002978	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
394221002979	PhoH-like protein; Region: PhoH; pfam02562
394221002980	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
394221002981	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
394221002982	trimer interface [polypeptide binding]; other site
394221002983	putative metal binding site [ion binding]; other site
394221002984	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
394221002985	PilZ domain; Region: PilZ; pfam07238
394221002986	PilZ domain; Region: PilZ; pfam07238
394221002987	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
394221002988	PAS domain; Region: PAS_5; pfam07310
394221002989	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
394221002990	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221002991	dimerization interface [polypeptide binding]; other site
394221002992	putative DNA binding site [nucleotide binding]; other site
394221002993	putative Zn2+ binding site [ion binding]; other site
394221002994	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
394221002995	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
394221002996	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
394221002997	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
394221002998	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
394221002999	FOG: CBS domain [General function prediction only]; Region: COG0517
394221003000	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
394221003001	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
394221003002	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
394221003003	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
394221003004	DNA binding residues [nucleotide binding]
394221003005	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
394221003006	dimer interface [polypeptide binding]; other site
394221003007	putative metal binding site [ion binding]; other site
394221003008	threonine synthase; Validated; Region: PRK09225
394221003009	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
394221003010	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221003011	catalytic residue [active]
394221003012	homoserine kinase; Provisional; Region: PRK01212
394221003013	Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527
394221003014	AAK_AK: Amino Acid Kinase Superfamily (AAK), Aspartokinase (AK); this CD includes the N-terminal catalytic domain of aspartokinase (4-L-aspartate-4-phosphotransferase;). AK is the first enzyme in the biosynthetic pathway of the aspartate family of amino...; Region: AAK_AK; cd04234
394221003015	putative catalytic residues [active]
394221003016	putative nucleotide binding site [chemical binding]; other site
394221003017	aspartate binding site [chemical binding]; other site
394221003018	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
394221003019	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
394221003020	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
394221003021	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
394221003022	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
394221003023	active site
394221003024	substrate-binding site [chemical binding]; other site
394221003025	metal-binding site [ion binding]
394221003026	ATP binding site [chemical binding]; other site
394221003027	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
394221003028	Pirin-related protein [General function prediction only]; Region: COG1741
394221003029	Pirin; Region: Pirin; pfam02678
394221003030	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
394221003031	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
394221003032	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
394221003033	PA/protease or protease-like domain interface [polypeptide binding]; other site
394221003034	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
394221003035	Peptidase family M28; Region: Peptidase_M28; pfam04389
394221003036	metal binding site [ion binding]; metal-binding site
394221003037	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
394221003038	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
394221003039	DXD motif; other site
394221003040	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
394221003041	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
394221003042	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
394221003043	putative C-terminal domain interface [polypeptide binding]; other site
394221003044	putative GSH binding site (G-site) [chemical binding]; other site
394221003045	putative dimer interface [polypeptide binding]; other site
394221003046	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
394221003047	putative N-terminal domain interface [polypeptide binding]; other site
394221003048	putative dimer interface [polypeptide binding]; other site
394221003049	putative substrate binding pocket (H-site) [chemical binding]; other site
394221003050	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
394221003051	Amidase; Region: Amidase; cl11426
394221003052	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
394221003053	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
394221003054	putative C-terminal domain interface [polypeptide binding]; other site
394221003055	putative GSH binding site (G-site) [chemical binding]; other site
394221003056	putative dimer interface [polypeptide binding]; other site
394221003057	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
394221003058	N-terminal domain interface [polypeptide binding]; other site
394221003059	dimer interface [polypeptide binding]; other site
394221003060	substrate binding pocket (H-site) [chemical binding]; other site
394221003061	Predicted amidohydrolase [General function prediction only]; Region: COG0388
394221003062	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
394221003063	putative active site [active]
394221003064	catalytic triad [active]
394221003065	putative dimer interface [polypeptide binding]; other site
394221003066	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
394221003067	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221003068	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221003069	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221003070	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
394221003071	Uncharacterized conserved protein [Function unknown]; Region: COG3743
394221003072	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
394221003073	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
394221003074	active site
394221003075	substrate binding site [chemical binding]; other site
394221003076	coenzyme B12 binding site [chemical binding]; other site
394221003077	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
394221003078	B12 binding site [chemical binding]; other site
394221003079	cobalt ligand [ion binding]; other site
394221003080	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
394221003081	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
394221003082	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
394221003083	Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of...; Region: HX; cl02471
394221003084	Metal binding sites [ion binding]; metal-binding site
394221003085	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
394221003086	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
394221003087	hinge; other site
394221003088	active site
394221003089	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
394221003090	hypothetical protein; Provisional; Region: PRK02853
394221003091	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
394221003092	Low molecular weight phosphatase family; Region: LMWPc; cl00105
394221003093	active site
394221003094	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
394221003095	rRNA binding site [nucleotide binding]; other site
394221003096	predicted 30S ribosome binding site; other site
394221003097	Maf-like protein; Region: Maf; pfam02545
394221003098	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
394221003099	active site
394221003100	dimer interface [polypeptide binding]; other site
394221003101	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
394221003102	homodimer interface [polypeptide binding]; other site
394221003103	oligonucleotide binding site [chemical binding]; other site
394221003104	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
394221003105	Domain of unknown function (DUF329); Region: DUF329; pfam03884
394221003106	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
394221003107	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
394221003108	putative active site [active]
394221003109	putative FMN binding site [chemical binding]; other site
394221003110	putative substrate binding site [chemical binding]; other site
394221003111	putative catalytic residue [active]
394221003112	ATP-grasp domain; Region: ATP-grasp_4; cl17255
394221003113	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
394221003114	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
394221003115	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
394221003116	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
394221003117	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221003118	NAD(P) binding site [chemical binding]; other site
394221003119	active site
394221003120	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
394221003121	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
394221003122	pyruvate carboxylase; Reviewed; Region: PRK12999
394221003123	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
394221003124	ATP-grasp domain; Region: ATP-grasp_4; cl17255
394221003125	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
394221003126	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
394221003127	active site
394221003128	catalytic residues [active]
394221003129	metal binding site [ion binding]; metal-binding site
394221003130	homodimer binding site [polypeptide binding]; other site
394221003131	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
394221003132	carboxyltransferase (CT) interaction site; other site
394221003133	biotinylation site [posttranslational modification]; other site
394221003134	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221003135	dimerization interface [polypeptide binding]; other site
394221003136	putative DNA binding site [nucleotide binding]; other site
394221003137	putative Zn2+ binding site [ion binding]; other site
394221003138	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
394221003139	hydrophobic ligand binding site; other site
394221003140	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
394221003141	threonine dehydratase; Provisional; Region: PRK07334
394221003142	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
394221003143	tetramer interface [polypeptide binding]; other site
394221003144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221003145	catalytic residue [active]
394221003146	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
394221003147	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
394221003148	active site
394221003149	intersubunit interactions; other site
394221003150	catalytic residue [active]
394221003151	Protein of unknown function (DUF2855); Region: DUF2855; pfam11017
394221003152	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
394221003153	Low-spin heme binding site [chemical binding]; other site
394221003154	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
394221003155	Putative water exit pathway; other site
394221003156	Binuclear center (active site) [active]
394221003157	Putative proton exit pathway; other site
394221003158	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
394221003159	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
394221003160	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
394221003161	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
394221003162	Cytochrome c; Region: Cytochrom_C; pfam00034
394221003163	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
394221003164	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
394221003165	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
394221003166	FixH; Region: FixH; pfam05751
394221003167	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
394221003168	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
394221003169	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
394221003170	metal-binding site [ion binding]
394221003171	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
394221003172	Soluble P-type ATPase [General function prediction only]; Region: COG4087
394221003173	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
394221003174	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
394221003175	Family description; Region: DsbD_2; pfam13386
394221003176	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
394221003177	MG2 domain; Region: A2M_N; pfam01835
394221003178	Alpha-2-macroglobulin family; Region: A2M; pfam00207
394221003179	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
394221003180	surface patch; other site
394221003181	thioester region; other site
394221003182	specificity defining residues; other site
394221003183	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
394221003184	Transglycosylase; Region: Transgly; pfam00912
394221003185	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
394221003186	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
394221003187	Asparaginase [Amino acid transport and metabolism]; Region: COG1446
394221003188	active site
394221003189	dimer interface [polypeptide binding]; other site
394221003190	catalytic nucleophile [active]
394221003191	Transcriptional regulator [Transcription]; Region: LysR; COG0583
394221003192	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
394221003193	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
394221003194	dimerization interface [polypeptide binding]; other site
394221003195	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
394221003196	active site clefts [active]
394221003197	zinc binding site [ion binding]; other site
394221003198	dimer interface [polypeptide binding]; other site
394221003199	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
394221003200	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
394221003201	uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016
394221003202	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
394221003203	exopolyphosphatase; Region: exo_poly_only; TIGR03706
394221003204	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
394221003205	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
394221003206	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221003207	S-adenosylmethionine binding site [chemical binding]; other site
394221003208	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
394221003209	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
394221003210	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
394221003211	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
394221003212	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
394221003213	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
394221003214	active site
394221003215	MAPEG family; Region: MAPEG; cl09190
394221003216	Protein of unknown function (DUF3088); Region: DUF3088; pfam11287
394221003217	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
394221003218	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221003219	S-adenosylmethionine binding site [chemical binding]; other site
394221003220	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
394221003221	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
394221003222	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
394221003223	YceI-like domain; Region: YceI; pfam04264
394221003224	GMP synthase; Reviewed; Region: guaA; PRK00074
394221003225	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
394221003226	AMP/PPi binding site [chemical binding]; other site
394221003227	candidate oxyanion hole; other site
394221003228	catalytic triad [active]
394221003229	potential glutamine specificity residues [chemical binding]; other site
394221003230	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
394221003231	ATP Binding subdomain [chemical binding]; other site
394221003232	Ligand Binding sites [chemical binding]; other site
394221003233	Dimerization subdomain; other site
394221003234	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
394221003235	DNA-binding site [nucleotide binding]; DNA binding site
394221003236	RNA-binding motif; other site
394221003237	Transcriptional regulator [Transcription]; Region: LysR; COG0583
394221003238	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
394221003239	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
394221003240	putative effector binding pocket; other site
394221003241	putative dimerization interface [polypeptide binding]; other site
394221003242	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
394221003243	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
394221003244	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
394221003245	SlyX; Region: SlyX; pfam04102
394221003246	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
394221003247	LytTr DNA-binding domain; Region: LytTR; smart00850
394221003248	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
394221003249	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
394221003250	TAP-like protein; Region: Abhydrolase_4; pfam08386
394221003251	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
394221003252	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
394221003253	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
394221003254	DNA binding residues [nucleotide binding]
394221003255	NnrU protein; Region: NnrU; pfam07298
394221003256	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
394221003257	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
394221003258	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
394221003259	DNA binding residues [nucleotide binding]
394221003260	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
394221003261	oligomerization interface [polypeptide binding]; other site
394221003262	active site
394221003263	metal binding site [ion binding]; metal-binding site
394221003264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
394221003265	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
394221003266	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
394221003267	Trp docking motif [polypeptide binding]; other site
394221003268	active site
394221003269	PQQ-like domain; Region: PQQ_2; pfam13360
394221003270	GTP-binding protein Der; Reviewed; Region: PRK00093
394221003271	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
394221003272	G1 box; other site
394221003273	GTP/Mg2+ binding site [chemical binding]; other site
394221003274	Switch I region; other site
394221003275	G2 box; other site
394221003276	Switch II region; other site
394221003277	G3 box; other site
394221003278	G4 box; other site
394221003279	G5 box; other site
394221003280	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
394221003281	G1 box; other site
394221003282	GTP/Mg2+ binding site [chemical binding]; other site
394221003283	Switch I region; other site
394221003284	G2 box; other site
394221003285	G3 box; other site
394221003286	Switch II region; other site
394221003287	G4 box; other site
394221003288	G5 box; other site
394221003289	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
394221003290	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221003291	NAD(P) binding site [chemical binding]; other site
394221003292	active site
394221003293	amidophosphoribosyltransferase; Provisional; Region: PRK09123
394221003294	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
394221003295	active site
394221003296	tetramer interface [polypeptide binding]; other site
394221003297	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
394221003298	active site
394221003299	Colicin V production protein; Region: Colicin_V; pfam02674
394221003300	DNA repair protein RadA; Provisional; Region: PRK11823
394221003301	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
394221003302	Walker A motif; other site
394221003303	ATP binding site [chemical binding]; other site
394221003304	Walker B motif; other site
394221003305	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
394221003306	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
394221003307	active site
394221003308	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
394221003309	dimer interface [polypeptide binding]; other site
394221003310	substrate binding site [chemical binding]; other site
394221003311	catalytic residues [active]
394221003312	replicative DNA helicase; Provisional; Region: PRK09165
394221003313	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
394221003314	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
394221003315	Walker A motif; other site
394221003316	ATP binding site [chemical binding]; other site
394221003317	Walker B motif; other site
394221003318	DNA binding loops [nucleotide binding]
394221003319	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
394221003320	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
394221003321	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
394221003322	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
394221003323	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
394221003324	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
394221003325	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
394221003326	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
394221003327	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
394221003328	NAD(P) binding site [chemical binding]; other site
394221003329	homotetramer interface [polypeptide binding]; other site
394221003330	homodimer interface [polypeptide binding]; other site
394221003331	active site
394221003332	acyl carrier protein; Provisional; Region: acpP; PRK00982
394221003333	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
394221003334	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
394221003335	dimer interface [polypeptide binding]; other site
394221003336	active site
394221003337	YceG-like family; Region: YceG; pfam02618
394221003338	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
394221003339	dimerization interface [polypeptide binding]; other site
394221003340	hypothetical protein; Provisional; Region: PRK11820
394221003341	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
394221003342	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
394221003343	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
394221003344	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
394221003345	catalytic site [active]
394221003346	G-X2-G-X-G-K; other site
394221003347	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
394221003348	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221003349	S-adenosylmethionine binding site [chemical binding]; other site
394221003350	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
394221003351	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
394221003352	SurA N-terminal domain; Region: SurA_N; pfam09312
394221003353	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
394221003354	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
394221003355	OstA-like protein; Region: OstA; cl00844
394221003356	Organic solvent tolerance protein; Region: OstA_C; pfam04453
394221003357	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
394221003358	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
394221003359	Predicted permeases [General function prediction only]; Region: COG0795
394221003360	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
394221003361	multifunctional aminopeptidase A; Provisional; Region: PRK00913
394221003362	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
394221003363	interface (dimer of trimers) [polypeptide binding]; other site
394221003364	Substrate-binding/catalytic site; other site
394221003365	Zn-binding sites [ion binding]; other site
394221003366	DNA polymerase III subunit chi; Validated; Region: PRK05728
394221003367	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
394221003368	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
394221003369	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
394221003370	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
394221003371	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221003372	Walker A/P-loop; other site
394221003373	ATP binding site [chemical binding]; other site
394221003374	Q-loop/lid; other site
394221003375	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
394221003376	ABC transporter signature motif; other site
394221003377	Walker B; other site
394221003378	D-loop; other site
394221003379	ABC transporter; Region: ABC_tran_2; pfam12848
394221003380	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
394221003381	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
394221003382	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
394221003383	Methyltransferase domain; Region: Methyltransf_31; pfam13847
394221003384	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221003385	S-adenosylmethionine binding site [chemical binding]; other site
394221003386	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
394221003387	active site
394221003388	multimer interface [polypeptide binding]; other site
394221003389	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
394221003390	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
394221003391	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
394221003392	active site
394221003393	purine riboside binding site [chemical binding]; other site
394221003394	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003395	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
394221003396	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003397	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
394221003398	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003399	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003400	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
394221003401	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003402	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003403	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003404	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003405	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
394221003406	Active site serine [active]
394221003407	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
394221003408	DNA binding site [nucleotide binding]
394221003409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221003410	TPR motif; other site
394221003411	binding surface
394221003412	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
394221003413	hypothetical protein; Provisional; Region: PRK09256
394221003414	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
394221003415	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221003416	NmrA-like family; Region: NmrA; pfam05368
394221003417	NAD(P) binding site [chemical binding]; other site
394221003418	active site
394221003419	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221003420	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221003421	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
394221003422	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
394221003423	active site
394221003424	substrate binding site [chemical binding]; other site
394221003425	cosubstrate binding site; other site
394221003426	catalytic site [active]
394221003427	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
394221003428	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
394221003429	dimerization interface [polypeptide binding]; other site
394221003430	putative ATP binding site [chemical binding]; other site
394221003431	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
394221003432	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
394221003433	polyphosphate kinase; Provisional; Region: PRK05443
394221003434	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
394221003435	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
394221003436	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
394221003437	putative domain interface [polypeptide binding]; other site
394221003438	putative active site [active]
394221003439	catalytic site [active]
394221003440	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
394221003441	putative domain interface [polypeptide binding]; other site
394221003442	putative active site [active]
394221003443	catalytic site [active]
394221003444	exopolyphosphatase; Region: exo_poly_only; TIGR03706
394221003445	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
394221003446	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
394221003447	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
394221003448	catalytic site [active]
394221003449	putative active site [active]
394221003450	putative substrate binding site [chemical binding]; other site
394221003451	HRDC domain; Region: HRDC; pfam00570
394221003452	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
394221003453	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
394221003454	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
394221003455	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
394221003456	putative acyl-acceptor binding pocket; other site
394221003457	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
394221003458	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
394221003459	putative acyl-acceptor binding pocket; other site
394221003460	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221003461	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221003462	flagellin; Reviewed; Region: PRK12687
394221003463	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
394221003464	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
394221003465	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
394221003466	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
394221003467	dimer interface [polypeptide binding]; other site
394221003468	anticodon binding site; other site
394221003469	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
394221003470	homodimer interface [polypeptide binding]; other site
394221003471	motif 1; other site
394221003472	active site
394221003473	motif 2; other site
394221003474	GAD domain; Region: GAD; pfam02938
394221003475	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
394221003476	active site
394221003477	motif 3; other site
394221003478	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
394221003479	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
394221003480	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003481	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
394221003482	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003483	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003484	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003485	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003486	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
394221003487	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003488	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221003489	TSCPD domain; Region: TSCPD; pfam12637
394221003490	NADH dehydrogenase; Validated; Region: PRK08183
394221003491	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
394221003492	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
394221003493	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
394221003494	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
394221003495	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
394221003496	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
394221003497	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
394221003498	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
394221003499	carboxyltransferase (CT) interaction site; other site
394221003500	biotinylation site [posttranslational modification]; other site
394221003501	Dehydroquinase class II; Region: DHquinase_II; pfam01220
394221003502	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
394221003503	trimer interface [polypeptide binding]; other site
394221003504	active site
394221003505	dimer interface [polypeptide binding]; other site
394221003506	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
394221003507	thiS-thiF/thiG interaction site; other site
394221003508	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
394221003509	ThiS interaction site; other site
394221003510	putative active site [active]
394221003511	tetramer interface [polypeptide binding]; other site
394221003512	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
394221003513	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
394221003514	catalytic residues [active]
394221003515	Cupin domain; Region: Cupin_2; cl17218
394221003516	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
394221003517	homotrimer interaction site [polypeptide binding]; other site
394221003518	putative active site [active]
394221003519	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
394221003520	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
394221003521	DNA polymerase IV; Provisional; Region: PRK02794
394221003522	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
394221003523	active site
394221003524	DNA binding site [nucleotide binding]
394221003525	fructokinase; Reviewed; Region: PRK09557
394221003526	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
394221003527	nucleotide binding site [chemical binding]; other site
394221003528	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221003529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221003530	active site
394221003531	phosphorylation site [posttranslational modification]
394221003532	intermolecular recognition site; other site
394221003533	dimerization interface [polypeptide binding]; other site
394221003534	response regulator PleD; Reviewed; Region: pleD; PRK09581
394221003535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221003536	active site
394221003537	phosphorylation site [posttranslational modification]
394221003538	intermolecular recognition site; other site
394221003539	dimerization interface [polypeptide binding]; other site
394221003540	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221003541	active site
394221003542	phosphorylation site [posttranslational modification]
394221003543	intermolecular recognition site; other site
394221003544	dimerization interface [polypeptide binding]; other site
394221003545	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
394221003546	metal binding site [ion binding]; metal-binding site
394221003547	active site
394221003548	I-site; other site
394221003549	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
394221003550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221003551	putative substrate translocation pore; other site
394221003552	Major Facilitator Superfamily; Region: MFS_1; pfam07690
394221003553	ribonuclease R; Region: RNase_R; TIGR02063
394221003554	RNB domain; Region: RNB; pfam00773
394221003555	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
394221003556	RNA binding site [nucleotide binding]; other site
394221003557	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
394221003558	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
394221003559	active site
394221003560	interdomain interaction site; other site
394221003561	putative metal-binding site [ion binding]; other site
394221003562	nucleotide binding site [chemical binding]; other site
394221003563	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
394221003564	domain I; other site
394221003565	DNA binding groove [nucleotide binding]
394221003566	phosphate binding site [ion binding]; other site
394221003567	domain II; other site
394221003568	domain III; other site
394221003569	nucleotide binding site [chemical binding]; other site
394221003570	catalytic site [active]
394221003571	domain IV; other site
394221003572	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
394221003573	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
394221003574	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
394221003575	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
394221003576	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
394221003577	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
394221003578	Sporulation related domain; Region: SPOR; pfam05036
394221003579	Phasin protein; Region: Phasin_2; pfam09361
394221003580	Uncharacterized conserved protein [Function unknown]; Region: COG2127
394221003581	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
394221003582	Clp amino terminal domain; Region: Clp_N; pfam02861
394221003583	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221003584	Walker A motif; other site
394221003585	ATP binding site [chemical binding]; other site
394221003586	Walker B motif; other site
394221003587	arginine finger; other site
394221003588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221003589	Walker A motif; other site
394221003590	ATP binding site [chemical binding]; other site
394221003591	Walker B motif; other site
394221003592	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
394221003593	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
394221003594	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
394221003595	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
394221003596	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221003597	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221003598	non-specific DNA binding site [nucleotide binding]; other site
394221003599	salt bridge; other site
394221003600	sequence-specific DNA binding site [nucleotide binding]; other site
394221003601	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
394221003602	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
394221003603	ATP binding site [chemical binding]; other site
394221003604	putative Mg++ binding site [ion binding]; other site
394221003605	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
394221003606	nucleotide binding region [chemical binding]; other site
394221003607	ATP-binding site [chemical binding]; other site
394221003608	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
394221003609	HRDC domain; Region: HRDC; pfam00570
394221003610	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
394221003611	HIT family signature motif; other site
394221003612	catalytic residue [active]
394221003613	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
394221003614	Protein of unknown function, DUF482; Region: DUF482; pfam04339
394221003615	Peptidase family M48; Region: Peptidase_M48; cl12018
394221003616	TPR repeat; Region: TPR_11; pfam13414
394221003617	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221003618	TPR motif; other site
394221003619	binding surface
394221003620	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
394221003621	RNA binding site [nucleotide binding]; other site
394221003622	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
394221003623	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
394221003624	AMIN domain; Region: AMIN; pfam11741
394221003625	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
394221003626	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
394221003627	active site
394221003628	metal binding site [ion binding]; metal-binding site
394221003629	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
394221003630	Transglycosylase; Region: Transgly; pfam00912
394221003631	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
394221003632	peptide chain release factor 2; Provisional; Region: PRK07342
394221003633	This domain is found in peptide chain release factors; Region: PCRF; smart00937
394221003634	RF-1 domain; Region: RF-1; pfam00472
394221003635	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221003636	dimerization interface [polypeptide binding]; other site
394221003637	putative DNA binding site [nucleotide binding]; other site
394221003638	Transcriptional regulators [Transcription]; Region: MarR; COG1846
394221003639	putative Zn2+ binding site [ion binding]; other site
394221003640	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
394221003641	Acyltransferase family; Region: Acyl_transf_3; pfam01757
394221003642	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
394221003643	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
394221003644	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
394221003645	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
394221003646	Peptidase family M23; Region: Peptidase_M23; pfam01551
394221003647	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
394221003648	dinuclear metal binding motif [ion binding]; other site
394221003649	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
394221003650	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
394221003651	catalytic triad [active]
394221003652	Protein of unknown function; Region: DUF3971; pfam13116
394221003653	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
394221003654	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
394221003655	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
394221003656	active site
394221003657	HIGH motif; other site
394221003658	dimer interface [polypeptide binding]; other site
394221003659	KMSKS motif; other site
394221003660	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
394221003661	RNA binding surface [nucleotide binding]; other site
394221003662	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
394221003663	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
394221003664	Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705
394221003665	Transcriptional regulator; Region: Rrf2; cl17282
394221003666	Rrf2 family protein; Region: rrf2_super; TIGR00738
394221003667	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
394221003668	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
394221003669	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221003670	catalytic residue [active]
394221003671	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
394221003672	putative ABC transporter; Region: ycf24; CHL00085
394221003673	Cupin domain; Region: Cupin_2; cl17218
394221003674	FeS assembly ATPase SufC; Region: sufC; TIGR01978
394221003675	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
394221003676	Walker A/P-loop; other site
394221003677	ATP binding site [chemical binding]; other site
394221003678	Q-loop/lid; other site
394221003679	ABC transporter signature motif; other site
394221003680	Walker B; other site
394221003681	D-loop; other site
394221003682	H-loop/switch region; other site
394221003683	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
394221003684	FeS assembly protein SufD; Region: sufD; TIGR01981
394221003685	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
394221003686	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
394221003687	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221003688	catalytic residue [active]
394221003689	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
394221003690	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
394221003691	putative glutathione S-transferase; Provisional; Region: PRK10357
394221003692	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
394221003693	putative C-terminal domain interface [polypeptide binding]; other site
394221003694	putative GSH binding site (G-site) [chemical binding]; other site
394221003695	putative dimer interface [polypeptide binding]; other site
394221003696	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
394221003697	dimer interface [polypeptide binding]; other site
394221003698	N-terminal domain interface [polypeptide binding]; other site
394221003699	putative substrate binding pocket (H-site) [chemical binding]; other site
394221003700	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
394221003701	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
394221003702	metal binding site [ion binding]; metal-binding site
394221003703	active site
394221003704	I-site; other site
394221003705	helicase 45; Provisional; Region: PTZ00424
394221003706	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
394221003707	ATP binding site [chemical binding]; other site
394221003708	Mg++ binding site [ion binding]; other site
394221003709	motif III; other site
394221003710	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
394221003711	nucleotide binding region [chemical binding]; other site
394221003712	ATP-binding site [chemical binding]; other site
394221003713	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221003714	Amidohydrolase; Region: Amidohydro_4; pfam13147
394221003715	active site
394221003716	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
394221003717	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
394221003718	active site
394221003719	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
394221003720	putative active site [active]
394221003721	Zn binding site [ion binding]; other site
394221003722	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
394221003723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221003724	ATP binding site [chemical binding]; other site
394221003725	Mg2+ binding site [ion binding]; other site
394221003726	G-X-G motif; other site
394221003727	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
394221003728	anchoring element; other site
394221003729	dimer interface [polypeptide binding]; other site
394221003730	ATP binding site [chemical binding]; other site
394221003731	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
394221003732	active site
394221003733	putative metal-binding site [ion binding]; other site
394221003734	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
394221003735	Autotransporter beta-domain; Region: Autotransporter; smart00869
394221003736	glutamine synthetase; Provisional; Region: glnA; PRK09469
394221003737	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
394221003738	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
394221003739	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
394221003740	Nitrogen regulatory protein P-II; Region: P-II; smart00938
394221003741	Uncharacterized conserved protein [Function unknown]; Region: COG0062
394221003742	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
394221003743	putative substrate binding site [chemical binding]; other site
394221003744	putative ATP binding site [chemical binding]; other site
394221003745	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
394221003746	Malic enzyme, N-terminal domain; Region: malic; pfam00390
394221003747	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
394221003748	putative NAD(P) binding site [chemical binding]; other site
394221003749	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
394221003750	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
394221003751	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
394221003752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221003753	S-adenosylmethionine binding site [chemical binding]; other site
394221003754	trigger factor; Provisional; Region: tig; PRK01490
394221003755	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
394221003756	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
394221003757	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
394221003758	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
394221003759	oligomer interface [polypeptide binding]; other site
394221003760	active site residues [active]
394221003761	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
394221003762	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
394221003763	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221003764	Walker A motif; other site
394221003765	ATP binding site [chemical binding]; other site
394221003766	Walker B motif; other site
394221003767	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
394221003768	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
394221003769	Found in ATP-dependent protease La (LON); Region: LON; smart00464
394221003770	Found in ATP-dependent protease La (LON); Region: LON; smart00464
394221003771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221003772	Walker A motif; other site
394221003773	ATP binding site [chemical binding]; other site
394221003774	Walker B motif; other site
394221003775	arginine finger; other site
394221003776	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
394221003777	Chorismate mutase type II; Region: CM_2; smart00830
394221003778	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
394221003779	Prephenate dehydratase; Region: PDT; pfam00800
394221003780	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
394221003781	putative L-Phe binding site [chemical binding]; other site
394221003782	yiaA/B two helix domain; Region: YiaAB; cl01759
394221003783	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
394221003784	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221003785	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221003786	WHG domain; Region: WHG; pfam13305
394221003787	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
394221003788	AAA domain; Region: AAA_26; pfam13500
394221003789	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
394221003790	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221003791	catalytic residue [active]
394221003792	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
394221003793	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
394221003794	inhibitor-cofactor binding pocket; inhibition site
394221003795	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221003796	catalytic residue [active]
394221003797	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221003798	putative DNA binding site [nucleotide binding]; other site
394221003799	putative Zn2+ binding site [ion binding]; other site
394221003800	Penicillinase repressor; Region: Pencillinase_R; cl17580
394221003801	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
394221003802	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221003803	putative metal binding site [ion binding]; other site
394221003804	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
394221003805	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
394221003806	helicase 45; Provisional; Region: PTZ00424
394221003807	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
394221003808	ATP binding site [chemical binding]; other site
394221003809	Mg++ binding site [ion binding]; other site
394221003810	motif III; other site
394221003811	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
394221003812	nucleotide binding region [chemical binding]; other site
394221003813	ATP-binding site [chemical binding]; other site
394221003814	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
394221003815	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
394221003816	Protein of unknown function, DUF599; Region: DUF599; pfam04654
394221003817	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
394221003818	NADH dehydrogenase subunit B; Validated; Region: PRK06411
394221003819	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
394221003820	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
394221003821	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
394221003822	NADH dehydrogenase subunit D; Validated; Region: PRK06075
394221003823	NADH dehydrogenase subunit E; Validated; Region: PRK07539
394221003824	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
394221003825	putative dimer interface [polypeptide binding]; other site
394221003826	[2Fe-2S] cluster binding site [ion binding]; other site
394221003827	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
394221003828	SLBB domain; Region: SLBB; pfam10531
394221003829	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
394221003830	NADH dehydrogenase subunit G; Validated; Region: PRK09130
394221003831	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
394221003832	catalytic loop [active]
394221003833	iron binding site [ion binding]; other site
394221003834	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
394221003835	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
394221003836	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
394221003837	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
394221003838	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
394221003839	4Fe-4S binding domain; Region: Fer4; pfam00037
394221003840	4Fe-4S binding domain; Region: Fer4; pfam00037
394221003841	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
394221003842	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
394221003843	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
394221003844	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
394221003845	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
394221003846	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
394221003847	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
394221003848	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
394221003849	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
394221003850	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
394221003851	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
394221003852	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
394221003853	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
394221003854	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
394221003855	pantothenate kinase; Reviewed; Region: PRK13318
394221003856	conserved hypothetical protein; Region: MG423; TIGR00649
394221003857	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
394221003858	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
394221003859	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221003860	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
394221003861	dimer interface [polypeptide binding]; other site
394221003862	substrate binding site [chemical binding]; other site
394221003863	metal binding site [ion binding]; metal-binding site
394221003864	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
394221003865	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
394221003866	prolyl-tRNA synthetase; Provisional; Region: PRK12325
394221003867	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
394221003868	dimer interface [polypeptide binding]; other site
394221003869	motif 1; other site
394221003870	active site
394221003871	motif 2; other site
394221003872	motif 3; other site
394221003873	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
394221003874	anticodon binding site; other site
394221003875	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
394221003876	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
394221003877	FtsX-like permease family; Region: FtsX; pfam02687
394221003878	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
394221003879	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
394221003880	Walker A/P-loop; other site
394221003881	ATP binding site [chemical binding]; other site
394221003882	Q-loop/lid; other site
394221003883	ABC transporter signature motif; other site
394221003884	Walker B; other site
394221003885	D-loop; other site
394221003886	H-loop/switch region; other site
394221003887	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
394221003888	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
394221003889	putative active site [active]
394221003890	putative PHP Thumb interface [polypeptide binding]; other site
394221003891	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
394221003892	generic binding surface II; other site
394221003893	generic binding surface I; other site
394221003894	SnoaL-like domain; Region: SnoaL_3; pfam13474
394221003895	SnoaL-like domain; Region: SnoaL_2; pfam12680
394221003896	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
394221003897	rRNA interaction site [nucleotide binding]; other site
394221003898	S8 interaction site; other site
394221003899	putative laminin-1 binding site; other site
394221003900	elongation factor Ts; Provisional; Region: tsf; PRK09377
394221003901	UBA/TS-N domain; Region: UBA; pfam00627
394221003902	Elongation factor TS; Region: EF_TS; pfam00889
394221003903	Elongation factor TS; Region: EF_TS; pfam00889
394221003904	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
394221003905	putative nucleotide binding site [chemical binding]; other site
394221003906	uridine monophosphate binding site [chemical binding]; other site
394221003907	homohexameric interface [polypeptide binding]; other site
394221003908	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
394221003909	ribosome recycling factor; Reviewed; Region: frr; PRK00083
394221003910	hinge region; other site
394221003911	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
394221003912	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
394221003913	catalytic residue [active]
394221003914	putative FPP diphosphate  binding site; other site
394221003915	putative FPP binding hydrophobic cleft; other site
394221003916	dimer interface [polypeptide binding]; other site
394221003917	putative IPP diphosphate binding site; other site
394221003918	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
394221003919	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
394221003920	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
394221003921	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
394221003922	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
394221003923	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
394221003924	RIP metalloprotease RseP; Region: TIGR00054
394221003925	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
394221003926	active site
394221003927	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
394221003928	protein binding site [polypeptide binding]; other site
394221003929	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
394221003930	protein binding site [polypeptide binding]; other site
394221003931	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
394221003932	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
394221003933	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
394221003934	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
394221003935	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
394221003936	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
394221003937	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
394221003938	Surface antigen; Region: Bac_surface_Ag; pfam01103
394221003939	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
394221003940	periplasmic chaperone; Provisional; Region: PRK10780
394221003941	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
394221003942	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
394221003943	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
394221003944	trimer interface [polypeptide binding]; other site
394221003945	active site
394221003946	UDP-GlcNAc binding site [chemical binding]; other site
394221003947	lipid binding site [chemical binding]; lipid-binding site
394221003948	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
394221003949	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
394221003950	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
394221003951	active site
394221003952	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
394221003953	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
394221003954	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
394221003955	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
394221003956	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
394221003957	dimer interface [polypeptide binding]; other site
394221003958	active site
394221003959	citrylCoA binding site [chemical binding]; other site
394221003960	NADH binding [chemical binding]; other site
394221003961	cationic pore residues; other site
394221003962	oxalacetate/citrate binding site [chemical binding]; other site
394221003963	coenzyme A binding site [chemical binding]; other site
394221003964	catalytic triad [active]
394221003965	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
394221003966	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
394221003967	active site
394221003968	HIGH motif; other site
394221003969	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
394221003970	active site
394221003971	KMSKS motif; other site
394221003972	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
394221003973	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
394221003974	Competence protein; Region: Competence; pfam03772
394221003975	LexA repressor; Validated; Region: PRK00215
394221003976	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
394221003977	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
394221003978	Catalytic site [active]
394221003979	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
394221003980	active site
394221003981	ribulose/triose binding site [chemical binding]; other site
394221003982	phosphate binding site [ion binding]; other site
394221003983	substrate (anthranilate) binding pocket [chemical binding]; other site
394221003984	product (indole) binding pocket [chemical binding]; other site
394221003985	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
394221003986	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
394221003987	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
394221003988	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
394221003989	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
394221003990	glutamine binding [chemical binding]; other site
394221003991	catalytic triad [active]
394221003992	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
394221003993	putative active site [active]
394221003994	NodB motif; other site
394221003995	anthranilate synthase component I; Provisional; Region: PRK13573
394221003996	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
394221003997	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
394221003998	SurA N-terminal domain; Region: SurA_N_3; cl07813
394221003999	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
394221004000	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
394221004001	triosephosphate isomerase; Provisional; Region: PRK14565
394221004002	substrate binding site [chemical binding]; other site
394221004003	dimer interface [polypeptide binding]; other site
394221004004	catalytic triad [active]
394221004005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
394221004006	active site
394221004007	phosphorylation site [posttranslational modification]
394221004008	dimerization interface [polypeptide binding]; other site
394221004009	CTP synthetase; Validated; Region: pyrG; PRK05380
394221004010	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
394221004011	Catalytic site [active]
394221004012	active site
394221004013	UTP binding site [chemical binding]; other site
394221004014	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
394221004015	active site
394221004016	putative oxyanion hole; other site
394221004017	catalytic triad [active]
394221004018	tyrosine decarboxylase; Region: PLN02880
394221004019	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
394221004020	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221004021	catalytic residue [active]
394221004022	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
394221004023	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
394221004024	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
394221004025	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
394221004026	Potassium binding sites [ion binding]; other site
394221004027	Cesium cation binding sites [ion binding]; other site
394221004028	enolase; Provisional; Region: eno; PRK00077
394221004029	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
394221004030	dimer interface [polypeptide binding]; other site
394221004031	metal binding site [ion binding]; metal-binding site
394221004032	substrate binding pocket [chemical binding]; other site
394221004033	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
394221004034	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
394221004035	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
394221004036	tetramer interface [polypeptide binding]; other site
394221004037	TPP-binding site [chemical binding]; other site
394221004038	heterodimer interface [polypeptide binding]; other site
394221004039	phosphorylation loop region [posttranslational modification]
394221004040	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
394221004041	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
394221004042	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
394221004043	E3 interaction surface; other site
394221004044	lipoyl attachment site [posttranslational modification]; other site
394221004045	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
394221004046	alpha subunit interface [polypeptide binding]; other site
394221004047	TPP binding site [chemical binding]; other site
394221004048	heterodimer interface [polypeptide binding]; other site
394221004049	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
394221004050	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
394221004051	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
394221004052	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
394221004053	E3 interaction surface; other site
394221004054	lipoyl attachment site [posttranslational modification]; other site
394221004055	e3 binding domain; Region: E3_binding; pfam02817
394221004056	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
394221004057	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
394221004058	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
394221004059	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
394221004060	ACT domain; Region: ACT_3; pfam10000
394221004061	Family description; Region: ACT_7; pfam13840
394221004062	Cupin domain; Region: Cupin_2; cl17218
394221004063	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
394221004064	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
394221004065	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
394221004066	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
394221004067	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
394221004068	acyl-activating enzyme (AAE) consensus motif; other site
394221004069	AMP binding site [chemical binding]; other site
394221004070	active site
394221004071	CoA binding site [chemical binding]; other site
394221004072	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
394221004073	Zn binding site [ion binding]; other site
394221004074	SET domain; Region: SET; pfam00856
394221004075	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
394221004076	lipoyl synthase; Provisional; Region: PRK05481
394221004077	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
394221004078	FeS/SAM binding site; other site
394221004079	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
394221004080	putative coenzyme Q binding site [chemical binding]; other site
394221004081	Competence-damaged protein; Region: CinA; pfam02464
394221004082	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
394221004083	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
394221004084	substrate binding site; other site
394221004085	dimer interface; other site
394221004086	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
394221004087	homotrimer interaction site [polypeptide binding]; other site
394221004088	zinc binding site [ion binding]; other site
394221004089	CDP-binding sites; other site
394221004090	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
394221004091	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
394221004092	FMN binding site [chemical binding]; other site
394221004093	active site
394221004094	catalytic residues [active]
394221004095	substrate binding site [chemical binding]; other site
394221004096	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
394221004097	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221004098	dimer interface [polypeptide binding]; other site
394221004099	phosphorylation site [posttranslational modification]
394221004100	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221004101	ATP binding site [chemical binding]; other site
394221004102	Mg2+ binding site [ion binding]; other site
394221004103	G-X-G motif; other site
394221004104	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
394221004105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221004106	active site
394221004107	phosphorylation site [posttranslational modification]
394221004108	intermolecular recognition site; other site
394221004109	dimerization interface [polypeptide binding]; other site
394221004110	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
394221004111	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
394221004112	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
394221004113	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
394221004114	dimerization interface [polypeptide binding]; other site
394221004115	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221004116	dimer interface [polypeptide binding]; other site
394221004117	phosphorylation site [posttranslational modification]
394221004118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221004119	ATP binding site [chemical binding]; other site
394221004120	Mg2+ binding site [ion binding]; other site
394221004121	G-X-G motif; other site
394221004122	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
394221004123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221004124	active site
394221004125	phosphorylation site [posttranslational modification]
394221004126	intermolecular recognition site; other site
394221004127	dimerization interface [polypeptide binding]; other site
394221004128	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221004129	Walker A motif; other site
394221004130	ATP binding site [chemical binding]; other site
394221004131	Walker B motif; other site
394221004132	arginine finger; other site
394221004133	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
394221004134	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
394221004135	TrkA-N domain; Region: TrkA_N; pfam02254
394221004136	TrkA-C domain; Region: TrkA_C; pfam02080
394221004137	TrkA-N domain; Region: TrkA_N; pfam02254
394221004138	TrkA-C domain; Region: TrkA_C; pfam02080
394221004139	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
394221004140	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
394221004141	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
394221004142	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
394221004143	homodimer interface [polypeptide binding]; other site
394221004144	substrate-cofactor binding pocket; other site
394221004145	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221004146	catalytic residue [active]
394221004147	bacterial Hfq-like; Region: Hfq; cd01716
394221004148	hexamer interface [polypeptide binding]; other site
394221004149	Sm1 motif; other site
394221004150	RNA binding site [nucleotide binding]; other site
394221004151	Sm2 motif; other site
394221004152	GTPases [General function prediction only]; Region: HflX; COG2262
394221004153	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
394221004154	HflX GTPase family; Region: HflX; cd01878
394221004155	G1 box; other site
394221004156	GTP/Mg2+ binding site [chemical binding]; other site
394221004157	Switch I region; other site
394221004158	G2 box; other site
394221004159	G3 box; other site
394221004160	Switch II region; other site
394221004161	G4 box; other site
394221004162	G5 box; other site
394221004163	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
394221004164	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
394221004165	homodimer interface [polypeptide binding]; other site
394221004166	metal binding site [ion binding]; metal-binding site
394221004167	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
394221004168	homodimer interface [polypeptide binding]; other site
394221004169	active site
394221004170	putative chemical substrate binding site [chemical binding]; other site
394221004171	metal binding site [ion binding]; metal-binding site
394221004172	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
394221004173	putative hydrolase; Provisional; Region: PRK02113
394221004174	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
394221004175	active site
394221004176	DNA polymerase III subunit delta'; Validated; Region: PRK07471
394221004177	DNA polymerase III subunit delta'; Validated; Region: PRK08485
394221004178	thymidylate kinase; Validated; Region: tmk; PRK00698
394221004179	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
394221004180	TMP-binding site; other site
394221004181	ATP-binding site [chemical binding]; other site
394221004182	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
394221004183	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
394221004184	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
394221004185	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
394221004186	rare lipoprotein A; Region: rlpA; TIGR00413
394221004187	Sporulation related domain; Region: SPOR; pfam05036
394221004188	Predicted integral membrane protein [Function unknown]; Region: COG5616
394221004189	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
394221004190	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
394221004191	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
394221004192	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
394221004193	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
394221004194	Coenzyme A binding pocket [chemical binding]; other site
394221004195	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
394221004196	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
394221004197	Coenzyme A binding pocket [chemical binding]; other site
394221004198	Predicted amidohydrolase [General function prediction only]; Region: COG0388
394221004199	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
394221004200	putative active site [active]
394221004201	catalytic triad [active]
394221004202	putative dimer interface [polypeptide binding]; other site
394221004203	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
394221004204	TMAO/DMSO reductase; Reviewed; Region: PRK05363
394221004205	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
394221004206	Moco binding site; other site
394221004207	metal coordination site [ion binding]; other site
394221004208	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
394221004209	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
394221004210	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
394221004211	putative active site [active]
394221004212	Zn binding site [ion binding]; other site
394221004213	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
394221004214	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
394221004215	active site
394221004216	Zn binding site [ion binding]; other site
394221004217	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
394221004218	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
394221004219	Putative cyclase; Region: Cyclase; cl00814
394221004220	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
394221004221	kynureninase; Region: kynureninase; TIGR01814
394221004222	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221004223	catalytic residue [active]
394221004224	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
394221004225	AsnC family; Region: AsnC_trans_reg; pfam01037
394221004226	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
394221004227	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
394221004228	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
394221004229	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
394221004230	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221004231	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
394221004232	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
394221004233	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
394221004234	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
394221004235	Predicted transcriptional regulator [Transcription]; Region: COG2378
394221004236	WYL domain; Region: WYL; pfam13280
394221004237	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
394221004238	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221004239	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221004240	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221004241	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
394221004242	CoA-transferase family III; Region: CoA_transf_3; pfam02515
394221004243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
394221004244	active site
394221004245	phosphorylation site [posttranslational modification]
394221004246	dimerization interface [polypeptide binding]; other site
394221004247	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
394221004248	I-site; other site
394221004249	active site
394221004250	metal binding site [ion binding]; metal-binding site
394221004251	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
394221004252	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
394221004253	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
394221004254	ATP binding site [chemical binding]; other site
394221004255	putative Mg++ binding site [ion binding]; other site
394221004256	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
394221004257	nucleotide binding region [chemical binding]; other site
394221004258	ATP-binding site [chemical binding]; other site
394221004259	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
394221004260	Uncharacterized conserved protein [Function unknown]; Region: COG2938
394221004261	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
394221004262	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
394221004263	generic binding surface II; other site
394221004264	ssDNA binding site; other site
394221004265	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
394221004266	ATP binding site [chemical binding]; other site
394221004267	putative Mg++ binding site [ion binding]; other site
394221004268	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
394221004269	nucleotide binding region [chemical binding]; other site
394221004270	ATP-binding site [chemical binding]; other site
394221004271	Uncharacterized conserved protein [Function unknown]; Region: COG2928
394221004272	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
394221004273	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
394221004274	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
394221004275	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
394221004276	DNA photolyase; Region: DNA_photolyase; pfam00875
394221004277	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
394221004278	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
394221004279	dimer interface [polypeptide binding]; other site
394221004280	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221004281	catalytic residue [active]
394221004282	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
394221004283	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
394221004284	active site residue [active]
394221004285	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
394221004286	active site residue [active]
394221004287	cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324
394221004288	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
394221004289	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221004290	catalytic residue [active]
394221004291	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
394221004292	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
394221004293	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
394221004294	DNA-binding site [nucleotide binding]; DNA binding site
394221004295	RNA-binding motif; other site
394221004296	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
394221004297	DNA-binding site [nucleotide binding]; DNA binding site
394221004298	RNA-binding motif; other site
394221004299	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
394221004300	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221004301	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221004302	non-specific DNA binding site [nucleotide binding]; other site
394221004303	salt bridge; other site
394221004304	sequence-specific DNA binding site [nucleotide binding]; other site
394221004305	multiple promoter invertase; Provisional; Region: mpi; PRK13413
394221004306	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
394221004307	catalytic residues [active]
394221004308	catalytic nucleophile [active]
394221004309	Presynaptic Site I dimer interface [polypeptide binding]; other site
394221004310	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
394221004311	Synaptic Flat tetramer interface [polypeptide binding]; other site
394221004312	Synaptic Site I dimer interface [polypeptide binding]; other site
394221004313	DNA binding site [nucleotide binding]
394221004314	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
394221004315	DNA-binding interface [nucleotide binding]; DNA binding site
394221004316	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
394221004317	Ca2+ binding site [ion binding]; other site
394221004318	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
394221004319	Ca2+ binding site [ion binding]; other site
394221004320	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
394221004321	Ca2+ binding site [ion binding]; other site
394221004322	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
394221004323	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
394221004324	active site
394221004325	Int/Topo IB signature motif; other site
394221004326	DNA binding site [nucleotide binding]
394221004327	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
394221004328	DHH family; Region: DHH; pfam01368
394221004329	DHHA1 domain; Region: DHHA1; pfam02272
394221004330	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
394221004331	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
394221004332	putative active site [active]
394221004333	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
394221004334	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
394221004335	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
394221004336	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
394221004337	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221004338	Walker A/P-loop; other site
394221004339	ATP binding site [chemical binding]; other site
394221004340	Q-loop/lid; other site
394221004341	ABC transporter signature motif; other site
394221004342	Walker B; other site
394221004343	D-loop; other site
394221004344	H-loop/switch region; other site
394221004345	Methyltransferase domain; Region: Methyltransf_31; pfam13847
394221004346	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221004347	S-adenosylmethionine binding site [chemical binding]; other site
394221004348	Transcriptional regulator [Transcription]; Region: LysR; COG0583
394221004349	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
394221004350	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
394221004351	dimerization interface [polypeptide binding]; other site
394221004352	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
394221004353	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
394221004354	23S rRNA interface [nucleotide binding]; other site
394221004355	L3 interface [polypeptide binding]; other site
394221004356	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
394221004357	MarR family; Region: MarR_2; pfam12802
394221004358	CAAX protease self-immunity; Region: Abi; pfam02517
394221004359	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
394221004360	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
394221004361	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
394221004362	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
394221004363	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
394221004364	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
394221004365	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
394221004366	DNA binding residues [nucleotide binding]
394221004367	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
394221004368	IHF dimer interface [polypeptide binding]; other site
394221004369	IHF - DNA interface [nucleotide binding]; other site
394221004370	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
394221004371	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
394221004372	dimer interface [polypeptide binding]; other site
394221004373	active site
394221004374	CoA binding pocket [chemical binding]; other site
394221004375	putative phosphate acyltransferase; Provisional; Region: PRK05331
394221004376	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981
394221004377	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
394221004378	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
394221004379	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221004380	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221004381	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
394221004382	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
394221004383	thiamine-monophosphate kinase; Region: thiL; TIGR01379
394221004384	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
394221004385	ATP binding site [chemical binding]; other site
394221004386	dimerization interface [polypeptide binding]; other site
394221004387	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
394221004388	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
394221004389	homopentamer interface [polypeptide binding]; other site
394221004390	active site
394221004391	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
394221004392	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
394221004393	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
394221004394	dimerization interface [polypeptide binding]; other site
394221004395	active site
394221004396	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
394221004397	Lumazine binding domain; Region: Lum_binding; pfam00677
394221004398	Lumazine binding domain; Region: Lum_binding; pfam00677
394221004399	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
394221004400	RibD C-terminal domain; Region: RibD_C; cl17279
394221004401	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
394221004402	ATP cone domain; Region: ATP-cone; pfam03477
394221004403	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
394221004404	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
394221004405	dimer interface [polypeptide binding]; other site
394221004406	active site
394221004407	glycine-pyridoxal phosphate binding site [chemical binding]; other site
394221004408	folate binding site [chemical binding]; other site
394221004409	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
394221004410	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
394221004411	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
394221004412	substrate-cofactor binding pocket; other site
394221004413	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221004414	catalytic residue [active]
394221004415	Transcriptional regulators [Transcription]; Region: MarR; COG1846
394221004416	MarR family; Region: MarR_2; pfam12802
394221004417	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
394221004418	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
394221004419	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
394221004420	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
394221004421	substrate binding site [chemical binding]; other site
394221004422	oxyanion hole (OAH) forming residues; other site
394221004423	trimer interface [polypeptide binding]; other site
394221004424	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
394221004425	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
394221004426	putative active site [active]
394221004427	homotetrameric interface [polypeptide binding]; other site
394221004428	metal binding site [ion binding]; metal-binding site
394221004429	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
394221004430	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
394221004431	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
394221004432	substrate binding pocket [chemical binding]; other site
394221004433	FAD binding site [chemical binding]; other site
394221004434	catalytic base [active]
394221004435	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
394221004436	dimer interface [polypeptide binding]; other site
394221004437	allosteric magnesium binding site [ion binding]; other site
394221004438	active site
394221004439	aspartate-rich active site metal binding site; other site
394221004440	Schiff base residues; other site
394221004441	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
394221004442	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
394221004443	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221004444	catalytic residue [active]
394221004445	Predicted membrane protein [Function unknown]; Region: COG2860
394221004446	UPF0126 domain; Region: UPF0126; pfam03458
394221004447	UPF0126 domain; Region: UPF0126; pfam03458
394221004448	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
394221004449	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
394221004450	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
394221004451	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
394221004452	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
394221004453	active site
394221004454	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
394221004455	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
394221004456	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
394221004457	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
394221004458	ligand binding site [chemical binding]; other site
394221004459	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
394221004460	putative hydrophobic ligand binding site [chemical binding]; other site
394221004461	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221004462	dimerization interface [polypeptide binding]; other site
394221004463	putative DNA binding site [nucleotide binding]; other site
394221004464	putative Zn2+ binding site [ion binding]; other site
394221004465	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
394221004466	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
394221004467	transmembrane helices; other site
394221004468	TrkA-C domain; Region: TrkA_C; pfam02080
394221004469	TrkA-C domain; Region: TrkA_C; pfam02080
394221004470	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
394221004471	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
394221004472	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
394221004473	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
394221004474	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
394221004475	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
394221004476	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
394221004477	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
394221004478	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
394221004479	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
394221004480	Domain of unknown function DUF20; Region: UPF0118; pfam01594
394221004481	Peptidase family M48; Region: Peptidase_M48; cl12018
394221004482	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
394221004483	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
394221004484	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
394221004485	CAP-like domain; other site
394221004486	active site
394221004487	primary dimer interface [polypeptide binding]; other site
394221004488	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
394221004489	Recombination protein O N terminal; Region: RecO_N; pfam11967
394221004490	Recombination protein O C terminal; Region: RecO_C; pfam02565
394221004491	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
394221004492	putative active site [active]
394221004493	GTPase Era; Reviewed; Region: era; PRK00089
394221004494	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
394221004495	G1 box; other site
394221004496	GTP/Mg2+ binding site [chemical binding]; other site
394221004497	Switch I region; other site
394221004498	G2 box; other site
394221004499	Switch II region; other site
394221004500	G3 box; other site
394221004501	G4 box; other site
394221004502	G5 box; other site
394221004503	KH domain; Region: KH_2; pfam07650
394221004504	ribonuclease III; Reviewed; Region: rnc; PRK00102
394221004505	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
394221004506	dimerization interface [polypeptide binding]; other site
394221004507	active site
394221004508	metal binding site [ion binding]; metal-binding site
394221004509	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
394221004510	dsRNA binding site [nucleotide binding]; other site
394221004511	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
394221004512	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
394221004513	active site
394221004514	hydrophilic channel; other site
394221004515	dimerization interface [polypeptide binding]; other site
394221004516	catalytic residues [active]
394221004517	active site lid [active]
394221004518	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
394221004519	active site
394221004520	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
394221004521	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
394221004522	Zn2+ binding site [ion binding]; other site
394221004523	Mg2+ binding site [ion binding]; other site
394221004524	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
394221004525	synthetase active site [active]
394221004526	NTP binding site [chemical binding]; other site
394221004527	metal binding site [ion binding]; metal-binding site
394221004528	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
394221004529	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
394221004530	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
394221004531	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
394221004532	catalytic center binding site [active]
394221004533	ATP binding site [chemical binding]; other site
394221004534	Uncharacterized conserved protein [Function unknown]; Region: COG1432
394221004535	LabA_like proteins; Region: LabA; cd10911
394221004536	putative metal binding site [ion binding]; other site
394221004537	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
394221004538	Fe-S cluster binding site [ion binding]; other site
394221004539	DNA binding site [nucleotide binding]
394221004540	active site
394221004541	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
394221004542	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
394221004543	conserved cys residue [active]
394221004544	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
394221004545	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
394221004546	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
394221004547	SmpB-tmRNA interface; other site
394221004548	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
394221004549	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
394221004550	dimer interface [polypeptide binding]; other site
394221004551	active site
394221004552	catalytic residue [active]
394221004553	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
394221004554	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
394221004555	N-acetyl-D-glucosamine binding site [chemical binding]; other site
394221004556	catalytic residue [active]
394221004557	HTH domain; Region: HTH_11; pfam08279
394221004558	WYL domain; Region: WYL; pfam13280
394221004559	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
394221004560	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221004561	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221004562	non-specific DNA binding site [nucleotide binding]; other site
394221004563	salt bridge; other site
394221004564	sequence-specific DNA binding site [nucleotide binding]; other site
394221004565	2TM domain; Region: 2TM; pfam13239
394221004566	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
394221004567	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
394221004568	tetramer interface [polypeptide binding]; other site
394221004569	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221004570	catalytic residue [active]
394221004571	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
394221004572	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
394221004573	dimer interface [polypeptide binding]; other site
394221004574	acyl-activating enzyme (AAE) consensus motif; other site
394221004575	putative active site [active]
394221004576	AMP binding site [chemical binding]; other site
394221004577	putative CoA binding site [chemical binding]; other site
394221004578	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
394221004579	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
394221004580	Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144
394221004581	putative FMN binding site [chemical binding]; other site
394221004582	putative dimer interface [polypeptide binding]; other site
394221004583	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
394221004584	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
394221004585	NAD(P) binding site [chemical binding]; other site
394221004586	hydroxyglutarate oxidase; Provisional; Region: PRK11728
394221004587	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221004588	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221004589	Amidohydrolase; Region: Amidohydro_4; pfam13147
394221004590	active site
394221004591	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
394221004592	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
394221004593	substrate-cofactor binding pocket; other site
394221004594	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221004595	catalytic residue [active]
394221004596	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221004597	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221004598	urocanate hydratase; Provisional; Region: PRK05414
394221004599	N-formylglutamate amidohydrolase; Region: FGase; cl01522
394221004600	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
394221004601	active sites [active]
394221004602	tetramer interface [polypeptide binding]; other site
394221004603	imidazolonepropionase; Validated; Region: PRK09356
394221004604	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
394221004605	active site
394221004606	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
394221004607	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
394221004608	active site
394221004609	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
394221004610	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
394221004611	DNA-binding site [nucleotide binding]; DNA binding site
394221004612	UTRA domain; Region: UTRA; pfam07702
394221004613	SnoaL-like domain; Region: SnoaL_3; pfam13474
394221004614	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
394221004615	LytTr DNA-binding domain; Region: LytTR; smart00850
394221004616	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221004617	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
394221004618	N-terminal plug; other site
394221004619	ligand-binding site [chemical binding]; other site
394221004620	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
394221004621	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
394221004622	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
394221004623	metal binding site [ion binding]; metal-binding site
394221004624	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
394221004625	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
394221004626	substrate binding site [chemical binding]; other site
394221004627	glutamase interaction surface [polypeptide binding]; other site
394221004628	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
394221004629	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
394221004630	catalytic residues [active]
394221004631	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
394221004632	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
394221004633	putative active site [active]
394221004634	oxyanion strand; other site
394221004635	catalytic triad [active]
394221004636	histidinol dehydrogenase; Region: hisD; TIGR00069
394221004637	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
394221004638	NAD binding site [chemical binding]; other site
394221004639	dimerization interface [polypeptide binding]; other site
394221004640	product binding site; other site
394221004641	substrate binding site [chemical binding]; other site
394221004642	zinc binding site [ion binding]; other site
394221004643	catalytic residues [active]
394221004644	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
394221004645	putative active site pocket [active]
394221004646	4-fold oligomerization interface [polypeptide binding]; other site
394221004647	metal binding residues [ion binding]; metal-binding site
394221004648	3-fold/trimer interface [polypeptide binding]; other site
394221004649	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
394221004650	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
394221004651	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
394221004652	Trp repressor protein; Region: Trp_repressor; cl17266
394221004653	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221004654	putative DNA binding site [nucleotide binding]; other site
394221004655	dimerization interface [polypeptide binding]; other site
394221004656	putative Zn2+ binding site [ion binding]; other site
394221004657	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
394221004658	active site residue [active]
394221004659	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
394221004660	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
394221004661	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
394221004662	high affinity sulphate transporter 1; Region: sulP; TIGR00815
394221004663	Sulfate transporter family; Region: Sulfate_transp; pfam00916
394221004664	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
394221004665	acetyl-CoA synthetase; Provisional; Region: PRK00174
394221004666	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
394221004667	active site
394221004668	CoA binding site [chemical binding]; other site
394221004669	acyl-activating enzyme (AAE) consensus motif; other site
394221004670	AMP binding site [chemical binding]; other site
394221004671	acetate binding site [chemical binding]; other site
394221004672	malate synthase A; Region: malate_syn_A; TIGR01344
394221004673	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
394221004674	active site
394221004675	isocitrate lyase; Provisional; Region: PRK15063
394221004676	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
394221004677	tetramer interface [polypeptide binding]; other site
394221004678	active site
394221004679	Mg2+/Mn2+ binding site [ion binding]; other site
394221004680	Helix-turn-helix domain; Region: HTH_19; pfam12844
394221004681	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
394221004682	Domain of unknown function (DUF955); Region: DUF955; pfam06114
394221004683	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
394221004684	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
394221004685	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
394221004686	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
394221004687	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
394221004688	dinuclear metal binding motif [ion binding]; other site
394221004689	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
394221004690	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
394221004691	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221004692	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221004693	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221004694	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221004695	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221004696	choline dehydrogenase; Validated; Region: PRK02106
394221004697	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
394221004698	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
394221004699	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
394221004700	NAD(P) binding site [chemical binding]; other site
394221004701	catalytic residues [active]
394221004702	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
394221004703	classical (c) SDRs; Region: SDR_c; cd05233
394221004704	NAD(P) binding site [chemical binding]; other site
394221004705	active site
394221004706	Response regulator receiver domain; Region: Response_reg; pfam00072
394221004707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221004708	active site
394221004709	phosphorylation site [posttranslational modification]
394221004710	intermolecular recognition site; other site
394221004711	dimerization interface [polypeptide binding]; other site
394221004712	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
394221004713	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
394221004714	tetramer interface [polypeptide binding]; other site
394221004715	active site
394221004716	Mg2+/Mn2+ binding site [ion binding]; other site
394221004717	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
394221004718	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
394221004719	active site
394221004720	putative substrate binding pocket [chemical binding]; other site
394221004721	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221004722	bile acid transporter; Region: bass; TIGR00841
394221004723	Sodium Bile acid symporter family; Region: SBF; cl17470
394221004724	Predicted transcriptional regulators [Transcription]; Region: COG1733
394221004725	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
394221004726	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
394221004727	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642
394221004728	putative metal binding site [ion binding]; other site
394221004729	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
394221004730	Interdomain contacts; other site
394221004731	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
394221004732	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
394221004733	NAD(P) binding site [chemical binding]; other site
394221004734	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
394221004735	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
394221004736	NAD binding site [chemical binding]; other site
394221004737	homodimer interface [polypeptide binding]; other site
394221004738	active site
394221004739	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
394221004740	putative active site [active]
394221004741	putative catalytic site [active]
394221004742	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
394221004743	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
394221004744	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
394221004745	acyl-activating enzyme (AAE) consensus motif; other site
394221004746	acyl-activating enzyme (AAE) consensus motif; other site
394221004747	putative AMP binding site [chemical binding]; other site
394221004748	putative active site [active]
394221004749	putative CoA binding site [chemical binding]; other site
394221004750	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
394221004751	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
394221004752	active site
394221004753	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
394221004754	classical (c) SDRs; Region: SDR_c; cd05233
394221004755	NAD(P) binding site [chemical binding]; other site
394221004756	active site
394221004757	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
394221004758	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
394221004759	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
394221004760	active site
394221004761	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
394221004762	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
394221004763	active site
394221004764	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
394221004765	Di-iron ligands [ion binding]; other site
394221004766	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
394221004767	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
394221004768	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
394221004769	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221004770	TPR motif; other site
394221004771	binding surface
394221004772	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
394221004773	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
394221004774	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
394221004775	catalytic residues [active]
394221004776	central insert; other site
394221004777	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
394221004778	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
394221004779	Na binding site [ion binding]; other site
394221004780	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
394221004781	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
394221004782	FAD binding site [chemical binding]; other site
394221004783	substrate binding pocket [chemical binding]; other site
394221004784	catalytic base [active]
394221004785	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
394221004786	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
394221004787	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
394221004788	TPR motif; other site
394221004789	binding surface
394221004790	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
394221004791	pseudoazurin; Region: pseudoazurin; TIGR02375
394221004792	BNR repeat-like domain; Region: BNR_2; pfam13088
394221004793	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
394221004794	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
394221004795	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221004796	NAD(P) binding site [chemical binding]; other site
394221004797	active site
394221004798	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
394221004799	oxidoreductase; Provisional; Region: PRK06196
394221004800	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221004801	NAD(P) binding site [chemical binding]; other site
394221004802	active site
394221004803	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
394221004804	Cytochrome P450; Region: p450; cl12078
394221004805	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
394221004806	Peptidase M15; Region: Peptidase_M15_3; cl01194
394221004807	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
394221004808	enoyl-CoA hydratase; Provisional; Region: PRK07509
394221004809	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
394221004810	substrate binding site [chemical binding]; other site
394221004811	oxyanion hole (OAH) forming residues; other site
394221004812	trimer interface [polypeptide binding]; other site
394221004813	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
394221004814	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
394221004815	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
394221004816	active site residue [active]
394221004817	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
394221004818	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
394221004819	putative GSH binding site (G-site) [chemical binding]; other site
394221004820	active site cysteine [active]
394221004821	putative C-terminal domain interface [polypeptide binding]; other site
394221004822	putative dimer interface [polypeptide binding]; other site
394221004823	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
394221004824	putative N-terminal domain interface [polypeptide binding]; other site
394221004825	putative dimer interface [polypeptide binding]; other site
394221004826	putative substrate binding pocket (H-site) [chemical binding]; other site
394221004827	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221004828	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221004829	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
394221004830	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
394221004831	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
394221004832	Amidohydrolase; Region: Amidohydro_5; pfam13594
394221004833	Amidohydrolase family; Region: Amidohydro_1; pfam01979
394221004834	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
394221004835	Bacterial sugar transferase; Region: Bac_transf; pfam02397
394221004836	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
394221004837	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
394221004838	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
394221004839	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
394221004840	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
394221004841	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
394221004842	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
394221004843	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
394221004844	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
394221004845	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
394221004846	active site
394221004847	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
394221004848	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
394221004849	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
394221004850	Chain length determinant protein; Region: Wzz; pfam02706
394221004851	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
394221004852	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
394221004853	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
394221004854	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
394221004855	Walker A/P-loop; other site
394221004856	ATP binding site [chemical binding]; other site
394221004857	Q-loop/lid; other site
394221004858	ABC transporter signature motif; other site
394221004859	Walker B; other site
394221004860	D-loop; other site
394221004861	H-loop/switch region; other site
394221004862	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
394221004863	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221004864	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
394221004865	EF-hand domain pair; Region: EF_hand_5; pfam13499
394221004866	Ca2+ binding site [ion binding]; other site
394221004867	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
394221004868	Sel1-like repeats; Region: SEL1; smart00671
394221004869	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
394221004870	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
394221004871	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
394221004872	Mechanosensitive ion channel; Region: MS_channel; pfam00924
394221004873	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
394221004874	putative active site [active]
394221004875	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
394221004876	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
394221004877	GatB domain; Region: GatB_Yqey; smart00845
394221004878	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
394221004879	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
394221004880	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
394221004881	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
394221004882	Predicted permeases [General function prediction only]; Region: COG0679
394221004883	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
394221004884	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
394221004885	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
394221004886	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
394221004887	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
394221004888	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
394221004889	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
394221004890	dihydroorotase; Validated; Region: pyrC; PRK09357
394221004891	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221004892	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
394221004893	active site
394221004894	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
394221004895	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
394221004896	DNA protecting protein DprA; Region: dprA; TIGR00732
394221004897	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
394221004898	ATPase MipZ; Region: MipZ; pfam09140
394221004899	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
394221004900	P-loop; other site
394221004901	Magnesium ion binding site [ion binding]; other site
394221004902	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
394221004903	Magnesium ion binding site [ion binding]; other site
394221004904	Sporulation related domain; Region: SPOR; pfam05036
394221004905	Pantoate-beta-alanine ligase; Region: PanC; cd00560
394221004906	pantoate--beta-alanine ligase; Region: panC; TIGR00018
394221004907	active site
394221004908	ATP-binding site [chemical binding]; other site
394221004909	pantoate-binding site; other site
394221004910	HXXH motif; other site
394221004911	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
394221004912	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
394221004913	Cupin-like domain; Region: Cupin_8; pfam13621
394221004914	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
394221004915	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
394221004916	ATP-grasp domain; Region: ATP-grasp_4; cl17255
394221004917	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
394221004918	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
394221004919	carboxyltransferase (CT) interaction site; other site
394221004920	biotinylation site [posttranslational modification]; other site
394221004921	Protein of unknown function (DUF817); Region: DUF817; pfam05675
394221004922	enoyl-CoA hydratase; Provisional; Region: PRK05995
394221004923	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
394221004924	substrate binding site [chemical binding]; other site
394221004925	oxyanion hole (OAH) forming residues; other site
394221004926	trimer interface [polypeptide binding]; other site
394221004927	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
394221004928	SOUL heme-binding protein; Region: SOUL; pfam04832
394221004929	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
394221004930	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
394221004931	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
394221004932	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
394221004933	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
394221004934	Virulence-associated protein E; Region: VirE; pfam05272
394221004935	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
394221004936	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
394221004937	ligand binding site [chemical binding]; other site
394221004938	flexible hinge region; other site
394221004939	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
394221004940	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
394221004941	active site
394221004942	nucleophile elbow; other site
394221004943	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
394221004944	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
394221004945	isovaleryl-CoA dehydrogenase; Region: PLN02519
394221004946	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
394221004947	substrate binding site [chemical binding]; other site
394221004948	FAD binding site [chemical binding]; other site
394221004949	catalytic base [active]
394221004950	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
394221004951	catalytic residue [active]
394221004952	Kelch motif; Region: Kelch_1; pfam01344
394221004953	Galactose oxidase, central domain; Region: Kelch_3; cl02701
394221004954	Kelch domain; Region: Kelch; smart00612
394221004955	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
394221004956	MgtE intracellular N domain; Region: MgtE_N; smart00924
394221004957	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
394221004958	Divalent cation transporter; Region: MgtE; cl00786
394221004959	hypothetical protein; Validated; Region: PRK06033
394221004960	lipoate-protein ligase B; Provisional; Region: PRK14341
394221004961	Protein of unknown function (DUF805); Region: DUF805; cl01224
394221004962	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
394221004963	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
394221004964	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
394221004965	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
394221004966	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
394221004967	carboxyltransferase (CT) interaction site; other site
394221004968	biotinylation site [posttranslational modification]; other site
394221004969	Ion channel; Region: Ion_trans_2; pfam07885
394221004970	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
394221004971	Fatty acid desaturase; Region: FA_desaturase; pfam00487
394221004972	putative di-iron ligands [ion binding]; other site
394221004973	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
394221004974	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
394221004975	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
394221004976	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
394221004977	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
394221004978	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
394221004979	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
394221004980	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
394221004981	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
394221004982	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
394221004983	ATP12 chaperone protein; Region: ATP12; cl02228
394221004984	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
394221004985	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
394221004986	motif II; other site
394221004987	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
394221004988	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
394221004989	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
394221004990	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
394221004991	active site
394221004992	CrcB-like protein; Region: CRCB; cl09114
394221004993	recombination factor protein RarA; Reviewed; Region: PRK13342
394221004994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221004995	Walker A motif; other site
394221004996	ATP binding site [chemical binding]; other site
394221004997	Walker B motif; other site
394221004998	arginine finger; other site
394221004999	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
394221005000	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
394221005001	putative dimer interface [polypeptide binding]; other site
394221005002	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221005003	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
394221005004	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
394221005005	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
394221005006	protein binding site [polypeptide binding]; other site
394221005007	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
394221005008	protein binding site [polypeptide binding]; other site
394221005009	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
394221005010	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
394221005011	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
394221005012	alphaNTD - beta interaction site [polypeptide binding]; other site
394221005013	alphaNTD homodimer interface [polypeptide binding]; other site
394221005014	alphaNTD - beta' interaction site [polypeptide binding]; other site
394221005015	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
394221005016	30S ribosomal protein S11; Validated; Region: PRK05309
394221005017	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
394221005018	30S ribosomal protein S13; Region: bact_S13; TIGR03631
394221005019	adenylate kinase; Provisional; Region: PRK14532
394221005020	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
394221005021	AMP-binding site [chemical binding]; other site
394221005022	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
394221005023	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
394221005024	SecY translocase; Region: SecY; pfam00344
394221005025	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
394221005026	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
394221005027	23S rRNA binding site [nucleotide binding]; other site
394221005028	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
394221005029	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
394221005030	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
394221005031	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
394221005032	23S rRNA interface [nucleotide binding]; other site
394221005033	L21e interface [polypeptide binding]; other site
394221005034	5S rRNA interface [nucleotide binding]; other site
394221005035	L27 interface [polypeptide binding]; other site
394221005036	L5 interface [polypeptide binding]; other site
394221005037	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
394221005038	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
394221005039	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
394221005040	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
394221005041	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
394221005042	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
394221005043	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
394221005044	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
394221005045	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
394221005046	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
394221005047	RNA binding site [nucleotide binding]; other site
394221005048	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
394221005049	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
394221005050	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
394221005051	putative translocon interaction site; other site
394221005052	23S rRNA interface [nucleotide binding]; other site
394221005053	signal recognition particle (SRP54) interaction site; other site
394221005054	L23 interface [polypeptide binding]; other site
394221005055	trigger factor interaction site; other site
394221005056	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
394221005057	23S rRNA interface [nucleotide binding]; other site
394221005058	5S rRNA interface [nucleotide binding]; other site
394221005059	putative antibiotic binding site [chemical binding]; other site
394221005060	L25 interface [polypeptide binding]; other site
394221005061	L27 interface [polypeptide binding]; other site
394221005062	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
394221005063	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
394221005064	G-X-X-G motif; other site
394221005065	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
394221005066	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
394221005067	putative translocon binding site; other site
394221005068	protein-rRNA interface [nucleotide binding]; other site
394221005069	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
394221005070	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
394221005071	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
394221005072	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
394221005073	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
394221005074	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
394221005075	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
394221005076	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
394221005077	elongation factor Tu; Reviewed; Region: PRK00049
394221005078	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
394221005079	G1 box; other site
394221005080	GEF interaction site [polypeptide binding]; other site
394221005081	GTP/Mg2+ binding site [chemical binding]; other site
394221005082	Switch I region; other site
394221005083	G2 box; other site
394221005084	G3 box; other site
394221005085	Switch II region; other site
394221005086	G4 box; other site
394221005087	G5 box; other site
394221005088	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
394221005089	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
394221005090	Antibiotic Binding Site [chemical binding]; other site
394221005091	elongation factor G; Reviewed; Region: PRK00007
394221005092	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
394221005093	G1 box; other site
394221005094	putative GEF interaction site [polypeptide binding]; other site
394221005095	GTP/Mg2+ binding site [chemical binding]; other site
394221005096	Switch I region; other site
394221005097	G2 box; other site
394221005098	G3 box; other site
394221005099	Switch II region; other site
394221005100	G4 box; other site
394221005101	G5 box; other site
394221005102	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
394221005103	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
394221005104	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
394221005105	30S ribosomal protein S7; Validated; Region: PRK05302
394221005106	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
394221005107	S17 interaction site [polypeptide binding]; other site
394221005108	S8 interaction site; other site
394221005109	16S rRNA interaction site [nucleotide binding]; other site
394221005110	streptomycin interaction site [chemical binding]; other site
394221005111	23S rRNA interaction site [nucleotide binding]; other site
394221005112	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
394221005113	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
394221005114	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
394221005115	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
394221005116	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
394221005117	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
394221005118	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
394221005119	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
394221005120	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
394221005121	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
394221005122	DNA binding site [nucleotide binding]
394221005123	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
394221005124	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
394221005125	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
394221005126	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
394221005127	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
394221005128	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
394221005129	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
394221005130	RPB1 interaction site [polypeptide binding]; other site
394221005131	RPB11 interaction site [polypeptide binding]; other site
394221005132	RPB10 interaction site [polypeptide binding]; other site
394221005133	RPB3 interaction site [polypeptide binding]; other site
394221005134	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
394221005135	core dimer interface [polypeptide binding]; other site
394221005136	peripheral dimer interface [polypeptide binding]; other site
394221005137	L10 interface [polypeptide binding]; other site
394221005138	L11 interface [polypeptide binding]; other site
394221005139	putative EF-Tu interaction site [polypeptide binding]; other site
394221005140	putative EF-G interaction site [polypeptide binding]; other site
394221005141	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
394221005142	23S rRNA interface [nucleotide binding]; other site
394221005143	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
394221005144	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
394221005145	mRNA/rRNA interface [nucleotide binding]; other site
394221005146	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
394221005147	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
394221005148	23S rRNA interface [nucleotide binding]; other site
394221005149	L7/L12 interface [polypeptide binding]; other site
394221005150	putative thiostrepton binding site; other site
394221005151	L25 interface [polypeptide binding]; other site
394221005152	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
394221005153	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
394221005154	putative homodimer interface [polypeptide binding]; other site
394221005155	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
394221005156	heterodimer interface [polypeptide binding]; other site
394221005157	homodimer interface [polypeptide binding]; other site
394221005158	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
394221005159	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221005160	S-adenosylmethionine binding site [chemical binding]; other site
394221005161	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221005162	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221005163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221005164	binding surface
394221005165	TPR motif; other site
394221005166	TPR repeat; Region: TPR_11; pfam13414
394221005167	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221005168	binding surface
394221005169	TPR motif; other site
394221005170	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221005171	binding surface
394221005172	TPR motif; other site
394221005173	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759
394221005174	Tetratricopeptide repeat; Region: TPR_16; pfam13432
394221005175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221005176	TPR motif; other site
394221005177	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
394221005178	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
394221005179	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
394221005180	elongation factor Tu; Reviewed; Region: PRK00049
394221005181	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
394221005182	G1 box; other site
394221005183	GEF interaction site [polypeptide binding]; other site
394221005184	GTP/Mg2+ binding site [chemical binding]; other site
394221005185	Switch I region; other site
394221005186	G2 box; other site
394221005187	G3 box; other site
394221005188	Switch II region; other site
394221005189	G4 box; other site
394221005190	G5 box; other site
394221005191	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
394221005192	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
394221005193	Antibiotic Binding Site [chemical binding]; other site
394221005194	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
394221005195	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
394221005196	metal binding site [ion binding]; metal-binding site
394221005197	active site
394221005198	I-site; other site
394221005199	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
394221005200	GIY-YIG motif/motif A; other site
394221005201	putative active site [active]
394221005202	putative metal binding site [ion binding]; other site
394221005203	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
394221005204	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
394221005205	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
394221005206	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
394221005207	Protein of unknown function (DUF819); Region: DUF819; cl02317
394221005208	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
394221005209	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
394221005210	putative C-terminal domain interface [polypeptide binding]; other site
394221005211	putative GSH binding site (G-site) [chemical binding]; other site
394221005212	putative dimer interface [polypeptide binding]; other site
394221005213	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
394221005214	dimer interface [polypeptide binding]; other site
394221005215	N-terminal domain interface [polypeptide binding]; other site
394221005216	putative substrate binding pocket (H-site) [chemical binding]; other site
394221005217	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
394221005218	homotrimer interaction site [polypeptide binding]; other site
394221005219	putative active site [active]
394221005220	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
394221005221	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
394221005222	metal binding site [ion binding]; metal-binding site
394221005223	putative dimer interface [polypeptide binding]; other site
394221005224	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
394221005225	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221005226	Walker A/P-loop; other site
394221005227	ATP binding site [chemical binding]; other site
394221005228	Q-loop/lid; other site
394221005229	ABC transporter signature motif; other site
394221005230	Walker B; other site
394221005231	D-loop; other site
394221005232	H-loop/switch region; other site
394221005233	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
394221005234	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
394221005235	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
394221005236	active site
394221005237	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
394221005238	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
394221005239	active site
394221005240	HIGH motif; other site
394221005241	KMSKS motif; other site
394221005242	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
394221005243	tRNA binding surface [nucleotide binding]; other site
394221005244	anticodon binding site; other site
394221005245	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
394221005246	Uncharacterized conserved protein [Function unknown]; Region: COG4544
394221005247	DNA Polymerase Y-family; Region: PolY_like; cd03468
394221005248	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
394221005249	DNA binding site [nucleotide binding]
394221005250	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
394221005251	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
394221005252	putative active site [active]
394221005253	putative PHP Thumb interface [polypeptide binding]; other site
394221005254	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
394221005255	generic binding surface I; other site
394221005256	generic binding surface II; other site
394221005257	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
394221005258	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
394221005259	Walker A/P-loop; other site
394221005260	ATP binding site [chemical binding]; other site
394221005261	Q-loop/lid; other site
394221005262	ABC transporter signature motif; other site
394221005263	Walker B; other site
394221005264	D-loop; other site
394221005265	H-loop/switch region; other site
394221005266	Cytochrome c2 [Energy production and conversion]; Region: COG3474
394221005267	aldolase II superfamily protein; Provisional; Region: PRK07044
394221005268	intersubunit interface [polypeptide binding]; other site
394221005269	active site
394221005270	Zn2+ binding site [ion binding]; other site
394221005271	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
394221005272	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
394221005273	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
394221005274	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
394221005275	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221005276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221005277	active site
394221005278	phosphorylation site [posttranslational modification]
394221005279	intermolecular recognition site; other site
394221005280	dimerization interface [polypeptide binding]; other site
394221005281	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
394221005282	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
394221005283	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221005284	short chain dehydrogenase; Provisional; Region: PRK12746
394221005285	NAD(P) binding site [chemical binding]; other site
394221005286	active site
394221005287	Transcriptional regulator [Transcription]; Region: LysR; COG0583
394221005288	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
394221005289	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
394221005290	putative effector binding pocket; other site
394221005291	dimerization interface [polypeptide binding]; other site
394221005292	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
394221005293	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
394221005294	putative NAD(P) binding site [chemical binding]; other site
394221005295	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
394221005296	Peptidase family M48; Region: Peptidase_M48; pfam01435
394221005297	AsmA family; Region: AsmA; pfam05170
394221005298	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
394221005299	Beta/Gamma crystallin; Region: Crystall; pfam00030
394221005300	Beta/Gamma crystallin; Region: Crystall; pfam00030
394221005301	Beta/Gamma crystallin; Region: Crystall; pfam00030
394221005302	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
394221005303	cofactor binding site; other site
394221005304	metal binding site [ion binding]; metal-binding site
394221005305	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221005306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221005307	active site
394221005308	phosphorylation site [posttranslational modification]
394221005309	intermolecular recognition site; other site
394221005310	dimerization interface [polypeptide binding]; other site
394221005311	succinylarginine dihydrolase; Provisional; Region: PRK13281
394221005312	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
394221005313	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
394221005314	NAD(P) binding site [chemical binding]; other site
394221005315	catalytic residues [active]
394221005316	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
394221005317	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
394221005318	hypothetical protein; Provisional; Region: PRK07338
394221005319	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
394221005320	metal binding site [ion binding]; metal-binding site
394221005321	dimer interface [polypeptide binding]; other site
394221005322	methionine gamma-lyase; Validated; Region: PRK07049
394221005323	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
394221005324	homodimer interface [polypeptide binding]; other site
394221005325	substrate-cofactor binding pocket; other site
394221005326	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221005327	catalytic residue [active]
394221005328	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
394221005329	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
394221005330	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
394221005331	ligand binding site [chemical binding]; other site
394221005332	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
394221005333	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
394221005334	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
394221005335	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
394221005336	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
394221005337	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
394221005338	TrkA-N domain; Region: TrkA_N; pfam02254
394221005339	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
394221005340	substrate binding pocket [chemical binding]; other site
394221005341	catalytic triad [active]
394221005342	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
394221005343	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
394221005344	Coenzyme A binding pocket [chemical binding]; other site
394221005345	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
394221005346	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
394221005347	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
394221005348	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
394221005349	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
394221005350	putative catalytic site [active]
394221005351	putative metal binding site [ion binding]; other site
394221005352	putative phosphate binding site [ion binding]; other site
394221005353	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
394221005354	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
394221005355	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
394221005356	active site
394221005357	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
394221005358	active site
394221005359	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
394221005360	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
394221005361	active site
394221005362	(T/H)XGH motif; other site
394221005363	DNA gyrase subunit A; Validated; Region: PRK05560
394221005364	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
394221005365	CAP-like domain; other site
394221005366	active site
394221005367	primary dimer interface [polypeptide binding]; other site
394221005368	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
394221005369	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
394221005370	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
394221005371	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
394221005372	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
394221005373	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
394221005374	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221005375	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221005376	dimer interface [polypeptide binding]; other site
394221005377	phosphorylation site [posttranslational modification]
394221005378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221005379	ATP binding site [chemical binding]; other site
394221005380	Mg2+ binding site [ion binding]; other site
394221005381	G-X-G motif; other site
394221005382	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221005383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221005384	active site
394221005385	phosphorylation site [posttranslational modification]
394221005386	intermolecular recognition site; other site
394221005387	dimerization interface [polypeptide binding]; other site
394221005388	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
394221005389	DNA binding site [nucleotide binding]
394221005390	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221005391	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221005392	EF-hand domain pair; Region: EF_hand_5; pfam13499
394221005393	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
394221005394	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
394221005395	Sulfatase; Region: Sulfatase; cl17466
394221005396	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
394221005397	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
394221005398	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
394221005399	putative NAD(P) binding site [chemical binding]; other site
394221005400	active site
394221005401	DoxX-like family; Region: DoxX_3; pfam13781
394221005402	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
394221005403	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
394221005404	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
394221005405	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
394221005406	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
394221005407	Penicillinase repressor; Region: Pencillinase_R; pfam03965
394221005408	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
394221005409	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
394221005410	dimer interface [polypeptide binding]; other site
394221005411	ssDNA binding site [nucleotide binding]; other site
394221005412	tetramer (dimer of dimers) interface [polypeptide binding]; other site
394221005413	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
394221005414	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
394221005415	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
394221005416	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
394221005417	CAAX protease self-immunity; Region: Abi; pfam02517
394221005418	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
394221005419	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
394221005420	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
394221005421	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
394221005422	Glucose inhibited division protein A; Region: GIDA; pfam01134
394221005423	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
394221005424	short chain dehydrogenase; Provisional; Region: PRK12827
394221005425	NADP binding site [chemical binding]; other site
394221005426	homodimer interface [polypeptide binding]; other site
394221005427	active site
394221005428	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
394221005429	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
394221005430	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
394221005431	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
394221005432	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221005433	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221005434	Protein of unknown function (DUF989); Region: DUF989; pfam06181
394221005435	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
394221005436	Protein export membrane protein; Region: SecD_SecF; pfam02355
394221005437	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
394221005438	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
394221005439	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
394221005440	Preprotein translocase subunit; Region: YajC; pfam02699
394221005441	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
394221005442	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
394221005443	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
394221005444	Peptidase family M23; Region: Peptidase_M23; pfam01551
394221005445	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
394221005446	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
394221005447	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
394221005448	VCBS repeat; Region: VCBS_repeat; TIGR01965
394221005449	VCBS repeat; Region: VCBS_repeat; TIGR01965
394221005450	VCBS repeat; Region: VCBS_repeat; TIGR01965
394221005451	VCBS repeat; Region: VCBS_repeat; TIGR01965
394221005452	seryl-tRNA synthetase; Provisional; Region: PRK05431
394221005453	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
394221005454	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
394221005455	dimer interface [polypeptide binding]; other site
394221005456	active site
394221005457	motif 1; other site
394221005458	motif 2; other site
394221005459	motif 3; other site
394221005460	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
394221005461	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
394221005462	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
394221005463	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
394221005464	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
394221005465	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
394221005466	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
394221005467	Sporulation related domain; Region: SPOR; pfam05036
394221005468	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
394221005469	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
394221005470	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
394221005471	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
394221005472	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
394221005473	putative FMN binding site [chemical binding]; other site
394221005474	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
394221005475	Zn binding site [ion binding]; other site
394221005476	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
394221005477	putative catalytic site [active]
394221005478	putative phosphate binding site [ion binding]; other site
394221005479	active site
394221005480	metal binding site A [ion binding]; metal-binding site
394221005481	DNA binding site [nucleotide binding]
394221005482	putative AP binding site [nucleotide binding]; other site
394221005483	putative metal binding site B [ion binding]; other site
394221005484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
394221005485	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
394221005486	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
394221005487	selenophosphate synthetase; Provisional; Region: PRK00943
394221005488	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
394221005489	dimerization interface [polypeptide binding]; other site
394221005490	putative ATP binding site [chemical binding]; other site
394221005491	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
394221005492	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
394221005493	active site residue [active]
394221005494	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
394221005495	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
394221005496	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
394221005497	HIGH motif; other site
394221005498	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
394221005499	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
394221005500	active site
394221005501	KMSKS motif; other site
394221005502	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
394221005503	tRNA binding surface [nucleotide binding]; other site
394221005504	anticodon binding site; other site
394221005505	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
394221005506	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221005507	dimer interface [polypeptide binding]; other site
394221005508	phosphorylation site [posttranslational modification]
394221005509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221005510	ATP binding site [chemical binding]; other site
394221005511	Mg2+ binding site [ion binding]; other site
394221005512	G-X-G motif; other site
394221005513	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221005514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221005515	active site
394221005516	phosphorylation site [posttranslational modification]
394221005517	intermolecular recognition site; other site
394221005518	dimerization interface [polypeptide binding]; other site
394221005519	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
394221005520	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
394221005521	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
394221005522	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
394221005523	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
394221005524	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
394221005525	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
394221005526	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00732
394221005527	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
394221005528	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
394221005529	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
394221005530	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
394221005531	MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar...; Region: MIT; cl00299
394221005532	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
394221005533	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
394221005534	Uncharacterized conserved protein [Function unknown]; Region: COG3334
394221005535	flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795
394221005536	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
394221005537	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
394221005538	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689
394221005539	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
394221005540	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
394221005541	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
394221005542	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
394221005543	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786
394221005544	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
394221005545	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
394221005546	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
394221005547	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
394221005548	flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787
394221005549	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
394221005550	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
394221005551	Rod binding protein; Region: Rod-binding; cl01626
394221005552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221005553	S-adenosylmethionine binding site [chemical binding]; other site
394221005554	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
394221005555	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
394221005556	NAD(P) binding site [chemical binding]; other site
394221005557	homodimer interface [polypeptide binding]; other site
394221005558	substrate binding site [chemical binding]; other site
394221005559	active site
394221005560	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
394221005561	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
394221005562	inhibitor-cofactor binding pocket; inhibition site
394221005563	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221005564	catalytic residue [active]
394221005565	flagellin; Reviewed; Region: PRK12687
394221005566	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
394221005567	FlaG protein; Region: FlaG; cl00591
394221005568	flagellin; Reviewed; Region: PRK12687
394221005569	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
394221005570	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
394221005571	flagellin; Reviewed; Region: PRK12687
394221005572	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
394221005573	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
394221005574	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794
394221005575	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
394221005576	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
394221005577	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221005578	TPR motif; other site
394221005579	binding surface
394221005580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221005581	binding surface
394221005582	TPR motif; other site
394221005583	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
394221005584	ligand binding site; other site
394221005585	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
394221005586	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
394221005587	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
394221005588	pseudaminic acid synthase; Region: PseI; TIGR03586
394221005589	NeuB family; Region: NeuB; pfam03102
394221005590	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
394221005591	NeuB binding interface [polypeptide binding]; other site
394221005592	putative substrate binding site [chemical binding]; other site
394221005593	Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980
394221005594	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
394221005595	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
394221005596	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
394221005597	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
394221005598	active site
394221005599	NeuB family; Region: NeuB; pfam03102
394221005600	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
394221005601	GIY-YIG motif/motif A; other site
394221005602	putative active site [active]
394221005603	putative metal binding site [ion binding]; other site
394221005604	Cupin domain; Region: Cupin_2; cl17218
394221005605	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
394221005606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221005607	Walker A motif; other site
394221005608	ATP binding site [chemical binding]; other site
394221005609	Walker B motif; other site
394221005610	arginine finger; other site
394221005611	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
394221005612	trimer interface [polypeptide binding]; other site
394221005613	active site
394221005614	substrate binding site [chemical binding]; other site
394221005615	CoA binding site [chemical binding]; other site
394221005616	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
394221005617	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
394221005618	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
394221005619	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221005620	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221005621	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221005622	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221005623	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221005624	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
394221005625	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
394221005626	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
394221005627	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
394221005628	putative C-terminal domain interface [polypeptide binding]; other site
394221005629	putative GSH binding site (G-site) [chemical binding]; other site
394221005630	putative dimer interface [polypeptide binding]; other site
394221005631	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
394221005632	N-terminal domain interface [polypeptide binding]; other site
394221005633	dimer interface [polypeptide binding]; other site
394221005634	substrate binding pocket (H-site) [chemical binding]; other site
394221005635	Chorismate mutase type II; Region: CM_2; smart00830
394221005636	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
394221005637	putative binding surface; other site
394221005638	active site
394221005639	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
394221005640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
394221005641	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
394221005642	nucleophilic elbow; other site
394221005643	catalytic triad; other site
394221005644	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
394221005645	HAMP domain; Region: HAMP; pfam00672
394221005646	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
394221005647	putative CheW interface [polypeptide binding]; other site
394221005648	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
394221005649	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221005650	Paraquat-inducible protein A; Region: PqiA; pfam04403
394221005651	Transcriptional regulators [Transcription]; Region: MarR; COG1846
394221005652	MarR family; Region: MarR_2; pfam12802
394221005653	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
394221005654	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
394221005655	maleylacetoacetate isomerase; Region: maiA; TIGR01262
394221005656	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
394221005657	C-terminal domain interface [polypeptide binding]; other site
394221005658	GSH binding site (G-site) [chemical binding]; other site
394221005659	putative dimer interface [polypeptide binding]; other site
394221005660	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
394221005661	dimer interface [polypeptide binding]; other site
394221005662	N-terminal domain interface [polypeptide binding]; other site
394221005663	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
394221005664	Protein of unknown function (DUF418); Region: DUF418; cl12135
394221005665	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
394221005666	Protein of unknown function (DUF330); Region: DUF330; cl01135
394221005667	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
394221005668	mce related protein; Region: MCE; pfam02470
394221005669	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
394221005670	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
394221005671	Walker A/P-loop; other site
394221005672	ATP binding site [chemical binding]; other site
394221005673	Q-loop/lid; other site
394221005674	ABC transporter signature motif; other site
394221005675	Walker B; other site
394221005676	D-loop; other site
394221005677	H-loop/switch region; other site
394221005678	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
394221005679	anti sigma factor interaction site; other site
394221005680	regulatory phosphorylation site [posttranslational modification]; other site
394221005681	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
394221005682	Permease; Region: Permease; pfam02405
394221005683	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221005684	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
394221005685	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
394221005686	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
394221005687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221005688	S-adenosylmethionine binding site [chemical binding]; other site
394221005689	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
394221005690	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
394221005691	Methyltransferase domain; Region: Methyltransf_24; pfam13578
394221005692	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
394221005693	TAP-like protein; Region: Abhydrolase_4; pfam08386
394221005694	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
394221005695	Na2 binding site [ion binding]; other site
394221005696	putative substrate binding site 1 [chemical binding]; other site
394221005697	Na binding site 1 [ion binding]; other site
394221005698	putative substrate binding site 2 [chemical binding]; other site
394221005699	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
394221005700	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
394221005701	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
394221005702	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
394221005703	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
394221005704	rod shape-determining protein MreC; Provisional; Region: PRK13922
394221005705	rod shape-determining protein MreC; Region: MreC; pfam04085
394221005706	rod shape-determining protein MreB; Provisional; Region: PRK13927
394221005707	MreB and similar proteins; Region: MreB_like; cd10225
394221005708	nucleotide binding site [chemical binding]; other site
394221005709	Mg binding site [ion binding]; other site
394221005710	putative protofilament interaction site [polypeptide binding]; other site
394221005711	RodZ interaction site [polypeptide binding]; other site
394221005712	Uncharacterized conserved protein [Function unknown]; Region: COG0398
394221005713	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
394221005714	ketol-acid reductoisomerase; Provisional; Region: PRK05479
394221005715	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
394221005716	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
394221005717	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
394221005718	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
394221005719	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
394221005720	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
394221005721	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
394221005722	protein binding site [polypeptide binding]; other site
394221005723	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
394221005724	protein binding site [polypeptide binding]; other site
394221005725	HflC protein; Region: hflC; TIGR01932
394221005726	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
394221005727	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
394221005728	HflK protein; Region: hflK; TIGR01933
394221005729	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
394221005730	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
394221005731	folate binding site [chemical binding]; other site
394221005732	NADP+ binding site [chemical binding]; other site
394221005733	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538
394221005734	metal binding site [ion binding]; metal-binding site
394221005735	thymidylate synthase; Reviewed; Region: thyA; PRK01827
394221005736	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
394221005737	dimerization interface [polypeptide binding]; other site
394221005738	active site
394221005739	LytTr DNA-binding domain; Region: LytTR; smart00850
394221005740	MltA-interacting protein MipA; Region: MipA; cl01504
394221005741	Predicted membrane protein [Function unknown]; Region: COG2259
394221005742	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
394221005743	hypothetical protein; Provisional; Region: PRK05409
394221005744	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
394221005745	RNA polymerase sigma factor; Provisional; Region: PRK12539
394221005746	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
394221005747	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
394221005748	DNA binding residues [nucleotide binding]
394221005749	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
394221005750	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
394221005751	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221005752	thymidine kinase; Provisional; Region: PRK04296
394221005753	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
394221005754	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221005755	PAS domain; Region: PAS_9; pfam13426
394221005756	putative active site [active]
394221005757	heme pocket [chemical binding]; other site
394221005758	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221005759	PAS domain; Region: PAS_9; pfam13426
394221005760	putative active site [active]
394221005761	heme pocket [chemical binding]; other site
394221005762	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
394221005763	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
394221005764	dimer interface [polypeptide binding]; other site
394221005765	putative CheW interface [polypeptide binding]; other site
394221005766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
394221005767	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
394221005768	CoenzymeA binding site [chemical binding]; other site
394221005769	subunit interaction site [polypeptide binding]; other site
394221005770	PHB binding site; other site
394221005771	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221005772	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
394221005773	fumarate hydratase; Reviewed; Region: fumC; PRK00485
394221005774	Class II fumarases; Region: Fumarase_classII; cd01362
394221005775	active site
394221005776	tetramer interface [polypeptide binding]; other site
394221005777	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
394221005778	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
394221005779	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
394221005780	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
394221005781	putative hydrophobic ligand binding site [chemical binding]; other site
394221005782	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221005783	dimerization interface [polypeptide binding]; other site
394221005784	putative DNA binding site [nucleotide binding]; other site
394221005785	putative Zn2+ binding site [ion binding]; other site
394221005786	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
394221005787	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
394221005788	Cl- selectivity filter; other site
394221005789	Cl- binding residues [ion binding]; other site
394221005790	pore gating glutamate residue; other site
394221005791	dimer interface [polypeptide binding]; other site
394221005792	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
394221005793	GIY-YIG motif/motif A; other site
394221005794	putative active site [active]
394221005795	putative metal binding site [ion binding]; other site
394221005796	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
394221005797	Part of AAA domain; Region: AAA_19; pfam13245
394221005798	Family description; Region: UvrD_C_2; pfam13538
394221005799	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
394221005800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221005801	S-adenosylmethionine binding site [chemical binding]; other site
394221005802	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221005803	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221005804	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
394221005805	LytTr DNA-binding domain; Region: LytTR; smart00850
394221005806	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
394221005807	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
394221005808	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
394221005809	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
394221005810	active site
394221005811	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221005812	dimer interface [polypeptide binding]; other site
394221005813	phosphorylation site [posttranslational modification]
394221005814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221005815	ATP binding site [chemical binding]; other site
394221005816	Mg2+ binding site [ion binding]; other site
394221005817	G-X-G motif; other site
394221005818	Response regulator receiver domain; Region: Response_reg; pfam00072
394221005819	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221005820	active site
394221005821	phosphorylation site [posttranslational modification]
394221005822	intermolecular recognition site; other site
394221005823	dimerization interface [polypeptide binding]; other site
394221005824	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
394221005825	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
394221005826	nucleotide binding pocket [chemical binding]; other site
394221005827	K-X-D-G motif; other site
394221005828	catalytic site [active]
394221005829	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
394221005830	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
394221005831	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
394221005832	Dimer interface [polypeptide binding]; other site
394221005833	BRCT sequence motif; other site
394221005834	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
394221005835	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
394221005836	Walker A/P-loop; other site
394221005837	ATP binding site [chemical binding]; other site
394221005838	Q-loop/lid; other site
394221005839	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
394221005840	ABC transporter signature motif; other site
394221005841	Walker B; other site
394221005842	D-loop; other site
394221005843	H-loop/switch region; other site
394221005844	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
394221005845	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
394221005846	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
394221005847	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
394221005848	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
394221005849	nucleotide binding site [chemical binding]; other site
394221005850	SulA interaction site; other site
394221005851	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
394221005852	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
394221005853	nucleotide binding site [chemical binding]; other site
394221005854	Cell division protein FtsA; Region: FtsA; pfam14450
394221005855	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
394221005856	Cell division protein FtsQ; Region: FtsQ; pfam03799
394221005857	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
394221005858	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
394221005859	ATP-grasp domain; Region: ATP-grasp_4; cl17255
394221005860	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
394221005861	FAD binding domain; Region: FAD_binding_4; pfam01565
394221005862	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
394221005863	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
394221005864	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
394221005865	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
394221005866	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
394221005867	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
394221005868	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
394221005869	active site
394221005870	homodimer interface [polypeptide binding]; other site
394221005871	cell division protein FtsW; Region: ftsW; TIGR02614
394221005872	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
394221005873	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
394221005874	NAD binding site [chemical binding]; other site
394221005875	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
394221005876	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
394221005877	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
394221005878	Mg++ binding site [ion binding]; other site
394221005879	putative catalytic motif [active]
394221005880	putative substrate binding site [chemical binding]; other site
394221005881	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
394221005882	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
394221005883	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
394221005884	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
394221005885	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
394221005886	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
394221005887	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
394221005888	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
394221005889	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
394221005890	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
394221005891	Cell division protein FtsL; Region: FtsL; cl11433
394221005892	MraW methylase family; Region: Methyltransf_5; cl17771
394221005893	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
394221005894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
394221005895	MraZ protein; Region: MraZ; pfam02381
394221005896	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
394221005897	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
394221005898	amidase catalytic site [active]
394221005899	Zn binding residues [ion binding]; other site
394221005900	substrate binding site [chemical binding]; other site
394221005901	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
394221005902	EamA-like transporter family; Region: EamA; cl17759
394221005903	EamA-like transporter family; Region: EamA; pfam00892
394221005904	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
394221005905	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
394221005906	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
394221005907	putative metal binding site [ion binding]; other site
394221005908	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
394221005909	HSP70 interaction site [polypeptide binding]; other site
394221005910	5-oxoprolinase; Region: PLN02666
394221005911	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
394221005912	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
394221005913	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
394221005914	YcfA-like protein; Region: YcfA; pfam07927
394221005915	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
394221005916	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
394221005917	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
394221005918	Fasciclin domain; Region: Fasciclin; pfam02469
394221005919	Predicted deacylase [General function prediction only]; Region: COG3608
394221005920	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
394221005921	putative active site [active]
394221005922	Zn binding site [ion binding]; other site
394221005923	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
394221005924	ATP-grasp domain; Region: ATP-grasp_4; cl17255
394221005925	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
394221005926	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221005927	dimerization interface [polypeptide binding]; other site
394221005928	putative DNA binding site [nucleotide binding]; other site
394221005929	putative Zn2+ binding site [ion binding]; other site
394221005930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221005931	S-adenosylmethionine binding site [chemical binding]; other site
394221005932	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
394221005933	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
394221005934	CAAX protease self-immunity; Region: Abi; pfam02517
394221005935	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
394221005936	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
394221005937	DNA binding residues [nucleotide binding]
394221005938	dimerization interface [polypeptide binding]; other site
394221005939	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
394221005940	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221005941	Walker A/P-loop; other site
394221005942	ATP binding site [chemical binding]; other site
394221005943	Q-loop/lid; other site
394221005944	ABC transporter signature motif; other site
394221005945	Walker B; other site
394221005946	D-loop; other site
394221005947	H-loop/switch region; other site
394221005948	ABC transporter; Region: ABC_tran_2; pfam12848
394221005949	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
394221005950	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
394221005951	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
394221005952	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221005953	Protein of unknown function DUF45; Region: DUF45; pfam01863
394221005954	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221005955	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221005956	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
394221005957	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
394221005958	ligand binding site [chemical binding]; other site
394221005959	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
394221005960	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
394221005961	active site
394221005962	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
394221005963	active site
394221005964	Zn binding site [ion binding]; other site
394221005965	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221005966	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221005967	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
394221005968	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221005969	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
394221005970	Protein export membrane protein; Region: SecD_SecF; cl14618
394221005971	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
394221005972	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
394221005973	phosphate binding site [ion binding]; other site
394221005974	hypothetical protein; Validated; Region: PRK07586
394221005975	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
394221005976	PYR/PP interface [polypeptide binding]; other site
394221005977	dimer interface [polypeptide binding]; other site
394221005978	TPP binding site [chemical binding]; other site
394221005979	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
394221005980	TPP-binding site [chemical binding]; other site
394221005981	dimer interface [polypeptide binding]; other site
394221005982	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
394221005983	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221005984	dimer interface [polypeptide binding]; other site
394221005985	phosphorylation site [posttranslational modification]
394221005986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221005987	ATP binding site [chemical binding]; other site
394221005988	Mg2+ binding site [ion binding]; other site
394221005989	G-X-G motif; other site
394221005990	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221005991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221005992	active site
394221005993	phosphorylation site [posttranslational modification]
394221005994	intermolecular recognition site; other site
394221005995	dimerization interface [polypeptide binding]; other site
394221005996	Response regulator receiver domain; Region: Response_reg; pfam00072
394221005997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221005998	active site
394221005999	phosphorylation site [posttranslational modification]
394221006000	intermolecular recognition site; other site
394221006001	dimerization interface [polypeptide binding]; other site
394221006002	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221006003	Uncharacterized conserved protein [Function unknown]; Region: COG2968
394221006004	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
394221006005	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
394221006006	tetramerization interface [polypeptide binding]; other site
394221006007	active site
394221006008	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
394221006009	Peptidase family M23; Region: Peptidase_M23; pfam01551
394221006010	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
394221006011	CHASE domain; Region: CHASE; cl01369
394221006012	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221006013	PAS fold; Region: PAS_3; pfam08447
394221006014	putative active site [active]
394221006015	heme pocket [chemical binding]; other site
394221006016	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221006017	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221006018	dimer interface [polypeptide binding]; other site
394221006019	phosphorylation site [posttranslational modification]
394221006020	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221006021	ATP binding site [chemical binding]; other site
394221006022	Mg2+ binding site [ion binding]; other site
394221006023	G-X-G motif; other site
394221006024	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221006025	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221006026	active site
394221006027	phosphorylation site [posttranslational modification]
394221006028	intermolecular recognition site; other site
394221006029	dimerization interface [polypeptide binding]; other site
394221006030	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
394221006031	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
394221006032	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
394221006033	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
394221006034	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
394221006035	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
394221006036	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
394221006037	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
394221006038	DNA binding residues [nucleotide binding]
394221006039	DNA primase, catalytic core; Region: dnaG; TIGR01391
394221006040	CHC2 zinc finger; Region: zf-CHC2; cl17510
394221006041	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
394221006042	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
394221006043	active site
394221006044	metal binding site [ion binding]; metal-binding site
394221006045	interdomain interaction site; other site
394221006046	Yqey-like protein; Region: YqeY; pfam09424
394221006047	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
394221006048	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
394221006049	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
394221006050	catalytic site [active]
394221006051	subunit interface [polypeptide binding]; other site
394221006052	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
394221006053	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
394221006054	peptide binding site [polypeptide binding]; other site
394221006055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
394221006056	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221006057	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221006058	salt bridge; other site
394221006059	non-specific DNA binding site [nucleotide binding]; other site
394221006060	sequence-specific DNA binding site [nucleotide binding]; other site
394221006061	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
394221006062	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221006063	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221006064	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
394221006065	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
394221006066	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
394221006067	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
394221006068	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
394221006069	ATP-grasp domain; Region: ATP-grasp_4; cl17255
394221006070	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
394221006071	IMP binding site; other site
394221006072	dimer interface [polypeptide binding]; other site
394221006073	partial ornithine binding site; other site
394221006074	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
394221006075	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
394221006076	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
394221006077	Uncharacterized conserved protein [Function unknown]; Region: COG3268
394221006078	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221006079	NAD(P) binding site [chemical binding]; other site
394221006080	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
394221006081	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
394221006082	Peptidase family M23; Region: Peptidase_M23; pfam01551
394221006083	Penicillinase repressor; Region: Pencillinase_R; cl17580
394221006084	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
394221006085	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
394221006086	Putative phosphatase (DUF442); Region: DUF442; cl17385
394221006087	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
394221006088	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
394221006089	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
394221006090	Protein of unknown function, DUF547; Region: DUF547; pfam04784
394221006091	Transcriptional regulator [Transcription]; Region: LysR; COG0583
394221006092	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
394221006093	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
394221006094	putative effector binding pocket; other site
394221006095	dimerization interface [polypeptide binding]; other site
394221006096	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
394221006097	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
394221006098	dimerization interface [polypeptide binding]; other site
394221006099	DPS ferroxidase diiron center [ion binding]; other site
394221006100	ion pore; other site
394221006101	aspartate aminotransferase; Provisional; Region: PRK05764
394221006102	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
394221006103	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221006104	homodimer interface [polypeptide binding]; other site
394221006105	catalytic residue [active]
394221006106	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
394221006107	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
394221006108	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
394221006109	metal ion-dependent adhesion site (MIDAS); other site
394221006110	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
394221006111	active site
394221006112	catalytic site [active]
394221006113	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
394221006114	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
394221006115	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221006116	catalytic residue [active]
394221006117	Response regulator receiver domain; Region: Response_reg; pfam00072
394221006118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221006119	active site
394221006120	phosphorylation site [posttranslational modification]
394221006121	intermolecular recognition site; other site
394221006122	dimerization interface [polypeptide binding]; other site
394221006123	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
394221006124	Response regulator receiver domain; Region: Response_reg; pfam00072
394221006125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221006126	active site
394221006127	phosphorylation site [posttranslational modification]
394221006128	intermolecular recognition site; other site
394221006129	dimerization interface [polypeptide binding]; other site
394221006130	Response regulator receiver domain; Region: Response_reg; pfam00072
394221006131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221006132	active site
394221006133	phosphorylation site [posttranslational modification]
394221006134	intermolecular recognition site; other site
394221006135	dimerization interface [polypeptide binding]; other site
394221006136	excinuclease ABC subunit B; Provisional; Region: PRK05298
394221006137	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
394221006138	ATP binding site [chemical binding]; other site
394221006139	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
394221006140	nucleotide binding region [chemical binding]; other site
394221006141	ATP-binding site [chemical binding]; other site
394221006142	Ultra-violet resistance protein B; Region: UvrB; pfam12344
394221006143	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
394221006144	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
394221006145	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
394221006146	cofactor binding site; other site
394221006147	DNA binding site [nucleotide binding]
394221006148	substrate interaction site [chemical binding]; other site
394221006149	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
394221006150	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
394221006151	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
394221006152	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
394221006153	P-loop; other site
394221006154	Magnesium ion binding site [ion binding]; other site
394221006155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221006156	S-adenosylmethionine binding site [chemical binding]; other site
394221006157	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
394221006158	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
394221006159	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
394221006160	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
394221006161	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
394221006162	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
394221006163	N-terminal domain interface [polypeptide binding]; other site
394221006164	dimer interface [polypeptide binding]; other site
394221006165	substrate binding pocket (H-site) [chemical binding]; other site
394221006166	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
394221006167	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
394221006168	pyruvate phosphate dikinase; Provisional; Region: PRK09279
394221006169	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
394221006170	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
394221006171	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
394221006172	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
394221006173	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
394221006174	Uncharacterized conserved protein [Function unknown]; Region: COG3791
394221006175	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
394221006176	dimer interface [polypeptide binding]; other site
394221006177	motif 1; other site
394221006178	active site
394221006179	motif 2; other site
394221006180	motif 3; other site
394221006181	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
394221006182	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
394221006183	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
394221006184	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
394221006185	substrate binding pocket [chemical binding]; other site
394221006186	chain length determination region; other site
394221006187	substrate-Mg2+ binding site; other site
394221006188	catalytic residues [active]
394221006189	aspartate-rich region 1; other site
394221006190	active site lid residues [active]
394221006191	aspartate-rich region 2; other site
394221006192	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
394221006193	Mg++ binding site [ion binding]; other site
394221006194	putative catalytic motif [active]
394221006195	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
394221006196	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
394221006197	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
394221006198	TPR repeat; Region: TPR_11; pfam13414
394221006199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221006200	binding surface
394221006201	TPR motif; other site
394221006202	TPR repeat; Region: TPR_11; pfam13414
394221006203	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
394221006204	hydroxyglutarate oxidase; Provisional; Region: PRK11728
394221006205	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
394221006206	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
394221006207	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
394221006208	Fe-S cluster binding site [ion binding]; other site
394221006209	active site
394221006210	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
394221006211	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
394221006212	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
394221006213	PAS domain S-box; Region: sensory_box; TIGR00229
394221006214	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221006215	putative active site [active]
394221006216	heme pocket [chemical binding]; other site
394221006217	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
394221006218	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
394221006219	metal binding site [ion binding]; metal-binding site
394221006220	active site
394221006221	I-site; other site
394221006222	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
394221006223	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
394221006224	RNA/DNA hybrid binding site [nucleotide binding]; other site
394221006225	active site
394221006226	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
394221006227	DNA methylase; Region: N6_N4_Mtase; pfam01555
394221006228	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221006229	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221006230	dimer interface [polypeptide binding]; other site
394221006231	phosphorylation site [posttranslational modification]
394221006232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221006233	ATP binding site [chemical binding]; other site
394221006234	Mg2+ binding site [ion binding]; other site
394221006235	G-X-G motif; other site
394221006236	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221006237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221006238	active site
394221006239	phosphorylation site [posttranslational modification]
394221006240	intermolecular recognition site; other site
394221006241	dimerization interface [polypeptide binding]; other site
394221006242	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
394221006243	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
394221006244	minor groove reading motif; other site
394221006245	helix-hairpin-helix signature motif; other site
394221006246	substrate binding pocket [chemical binding]; other site
394221006247	active site
394221006248	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
394221006249	DNA binding and oxoG recognition site [nucleotide binding]
394221006250	Protein of unknown function (DUF721); Region: DUF721; pfam05258
394221006251	Thioredoxin; Region: Thioredoxin_4; pfam13462
394221006252	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
394221006253	Thioredoxin; Region: Thioredoxin_4; pfam13462
394221006254	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
394221006255	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
394221006256	AAA domain; Region: AAA_23; pfam13476
394221006257	Walker A/P-loop; other site
394221006258	ATP binding site [chemical binding]; other site
394221006259	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
394221006260	ABC transporter signature motif; other site
394221006261	Walker B; other site
394221006262	D-loop; other site
394221006263	H-loop/switch region; other site
394221006264	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
394221006265	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
394221006266	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
394221006267	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
394221006268	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
394221006269	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
394221006270	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
394221006271	Domain of unknown function (DUF4345); Region: DUF4345; pfam14248
394221006272	Cupin; Region: Cupin_6; pfam12852
394221006273	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
394221006274	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
394221006275	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
394221006276	tetramer interface [polypeptide binding]; other site
394221006277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221006278	catalytic residue [active]
394221006279	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
394221006280	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
394221006281	tetramer interface [polypeptide binding]; other site
394221006282	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221006283	catalytic residue [active]
394221006284	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
394221006285	lipoyl attachment site [posttranslational modification]; other site
394221006286	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
394221006287	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
394221006288	LabA_like proteins; Region: LabA_like; cd06167
394221006289	putative metal binding site [ion binding]; other site
394221006290	Uncharacterized conserved protein [Function unknown]; Region: COG1432
394221006291	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
394221006292	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
394221006293	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
394221006294	active site
394221006295	HIGH motif; other site
394221006296	nucleotide binding site [chemical binding]; other site
394221006297	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
394221006298	KMSK motif region; other site
394221006299	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
394221006300	tRNA binding surface [nucleotide binding]; other site
394221006301	anticodon binding site; other site
394221006302	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
394221006303	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
394221006304	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
394221006305	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
394221006306	RNA/DNA hybrid binding site [nucleotide binding]; other site
394221006307	active site
394221006308	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
394221006309	GAF domain; Region: GAF; pfam01590
394221006310	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221006311	PAS domain; Region: PAS_9; pfam13426
394221006312	putative active site [active]
394221006313	heme pocket [chemical binding]; other site
394221006314	PAS domain; Region: PAS_9; pfam13426
394221006315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221006316	putative active site [active]
394221006317	heme pocket [chemical binding]; other site
394221006318	PAS domain; Region: PAS_9; pfam13426
394221006319	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221006320	PAS fold; Region: PAS_3; pfam08447
394221006321	putative active site [active]
394221006322	heme pocket [chemical binding]; other site
394221006323	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221006324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221006325	dimer interface [polypeptide binding]; other site
394221006326	phosphorylation site [posttranslational modification]
394221006327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221006328	ATP binding site [chemical binding]; other site
394221006329	Mg2+ binding site [ion binding]; other site
394221006330	G-X-G motif; other site
394221006331	Response regulator receiver domain; Region: Response_reg; pfam00072
394221006332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221006333	active site
394221006334	phosphorylation site [posttranslational modification]
394221006335	intermolecular recognition site; other site
394221006336	dimerization interface [polypeptide binding]; other site
394221006337	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
394221006338	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
394221006339	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
394221006340	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
394221006341	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
394221006342	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
394221006343	catalytic triad [active]
394221006344	dimer interface [polypeptide binding]; other site
394221006345	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
394221006346	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
394221006347	CoenzymeA binding site [chemical binding]; other site
394221006348	subunit interaction site [polypeptide binding]; other site
394221006349	PHB binding site; other site
394221006350	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
394221006351	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
394221006352	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
394221006353	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
394221006354	Protein of unknown function (DUF983); Region: DUF983; cl02211
394221006355	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
394221006356	Subunit III/VIIa interface [polypeptide binding]; other site
394221006357	Phospholipid binding site [chemical binding]; other site
394221006358	Subunit I/III interface [polypeptide binding]; other site
394221006359	Subunit III/VIb interface [polypeptide binding]; other site
394221006360	Subunit III/VIa interface; other site
394221006361	Subunit III/Vb interface [polypeptide binding]; other site
394221006362	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442
394221006363	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
394221006364	UbiA prenyltransferase family; Region: UbiA; pfam01040
394221006365	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
394221006366	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
394221006367	Subunit I/III interface [polypeptide binding]; other site
394221006368	D-pathway; other site
394221006369	Subunit I/VIIc interface [polypeptide binding]; other site
394221006370	Subunit I/IV interface [polypeptide binding]; other site
394221006371	Subunit I/II interface [polypeptide binding]; other site
394221006372	Low-spin heme (heme a) binding site [chemical binding]; other site
394221006373	Subunit I/VIIa interface [polypeptide binding]; other site
394221006374	Subunit I/VIa interface [polypeptide binding]; other site
394221006375	Dimer interface; other site
394221006376	Putative water exit pathway; other site
394221006377	Binuclear center (heme a3/CuB) [ion binding]; other site
394221006378	K-pathway; other site
394221006379	Subunit I/Vb interface [polypeptide binding]; other site
394221006380	Putative proton exit pathway; other site
394221006381	Subunit I/VIb interface; other site
394221006382	Subunit I/VIc interface [polypeptide binding]; other site
394221006383	Electron transfer pathway; other site
394221006384	Subunit I/VIIIb interface [polypeptide binding]; other site
394221006385	Subunit I/VIIb interface [polypeptide binding]; other site
394221006386	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
394221006387	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
394221006388	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
394221006389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221006390	binding surface
394221006391	TPR motif; other site
394221006392	TPR repeat; Region: TPR_11; pfam13414
394221006393	protease TldD; Provisional; Region: tldD; PRK10735
394221006394	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221006395	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221006396	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
394221006397	catalytic motif [active]
394221006398	Catalytic residue [active]
394221006399	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
394221006400	catalytic motif [active]
394221006401	Catalytic residue [active]
394221006402	POT family; Region: PTR2; cl17359
394221006403	POT family; Region: PTR2; cl17359
394221006404	glutamate--cysteine ligase; Region: PLN02611
394221006405	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
394221006406	RNA methyltransferase, RsmE family; Region: TIGR00046
394221006407	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
394221006408	UbiA prenyltransferase family; Region: UbiA; pfam01040
394221006409	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
394221006410	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
394221006411	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
394221006412	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
394221006413	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
394221006414	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
394221006415	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221006416	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
394221006417	dimer interface [polypeptide binding]; other site
394221006418	ligand binding site [chemical binding]; other site
394221006419	Predicted methyltransferase [General function prediction only]; Region: COG3897
394221006420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
394221006421	S-adenosylmethionine binding site [chemical binding]; other site
394221006422	Transcriptional regulators [Transcription]; Region: MarR; COG1846
394221006423	MarR family; Region: MarR_2; pfam12802
394221006424	enoyl-CoA hydratase; Provisional; Region: PRK06688
394221006425	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
394221006426	substrate binding site [chemical binding]; other site
394221006427	oxyanion hole (OAH) forming residues; other site
394221006428	trimer interface [polypeptide binding]; other site
394221006429	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221006430	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221006431	Sensors of blue-light using FAD; Region: BLUF; smart01034
394221006432	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
394221006433	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
394221006434	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
394221006435	inhibitor binding site; inhibition site
394221006436	catalytic motif [active]
394221006437	Catalytic residue [active]
394221006438	Active site flap [active]
394221006439	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
394221006440	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
394221006441	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
394221006442	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
394221006443	catalytic residue [active]
394221006444	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
394221006445	ArsC family; Region: ArsC; pfam03960
394221006446	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
394221006447	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
394221006448	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221006449	non-specific DNA binding site [nucleotide binding]; other site
394221006450	salt bridge; other site
394221006451	sequence-specific DNA binding site [nucleotide binding]; other site
394221006452	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
394221006453	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
394221006454	GAF domain; Region: GAF; pfam01590
394221006455	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
394221006456	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
394221006457	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
394221006458	aspartate kinase; Reviewed; Region: PRK06635
394221006459	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
394221006460	putative nucleotide binding site [chemical binding]; other site
394221006461	putative catalytic residues [active]
394221006462	putative Mg ion binding site [ion binding]; other site
394221006463	putative aspartate binding site [chemical binding]; other site
394221006464	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
394221006465	putative allosteric regulatory site; other site
394221006466	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
394221006467	putative allosteric regulatory residue; other site
394221006468	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
394221006469	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221006470	S-adenosylmethionine binding site [chemical binding]; other site
394221006471	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
394221006472	nitrilase; Region: PLN02798
394221006473	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
394221006474	putative active site [active]
394221006475	catalytic triad [active]
394221006476	dimer interface [polypeptide binding]; other site
394221006477	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
394221006478	GSH binding site [chemical binding]; other site
394221006479	catalytic residues [active]
394221006480	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
394221006481	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
394221006482	active site
394221006483	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
394221006484	Methyltransferase domain; Region: Methyltransf_11; pfam08241
394221006485	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
394221006486	active site
394221006487	8-oxo-dGMP binding site [chemical binding]; other site
394221006488	nudix motif; other site
394221006489	metal binding site [ion binding]; metal-binding site
394221006490	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
394221006491	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
394221006492	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
394221006493	SEC-C motif; Region: SEC-C; pfam02810
394221006494	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
394221006495	Coenzyme A binding pocket [chemical binding]; other site
394221006496	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
394221006497	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
394221006498	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
394221006499	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
394221006500	active site
394221006501	DNA binding site [nucleotide binding]
394221006502	Int/Topo IB signature motif; other site
394221006503	shikimate kinase; Provisional; Region: PRK13946
394221006504	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
394221006505	ADP binding site [chemical binding]; other site
394221006506	magnesium binding site [ion binding]; other site
394221006507	putative shikimate binding site; other site
394221006508	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
394221006509	active site
394221006510	dimer interface [polypeptide binding]; other site
394221006511	metal binding site [ion binding]; metal-binding site
394221006512	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
394221006513	Domain of unknown function DUF21; Region: DUF21; pfam01595
394221006514	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
394221006515	Transporter associated domain; Region: CorC_HlyC; smart01091
394221006516	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
394221006517	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
394221006518	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
394221006519	HSP70 interaction site [polypeptide binding]; other site
394221006520	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
394221006521	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
394221006522	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
394221006523	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
394221006524	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
394221006525	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
394221006526	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
394221006527	Outer membrane efflux protein; Region: OEP; pfam02321
394221006528	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
394221006529	putative homodimer interface [polypeptide binding]; other site
394221006530	putative homotetramer interface [polypeptide binding]; other site
394221006531	putative allosteric switch controlling residues; other site
394221006532	putative metal binding site [ion binding]; other site
394221006533	putative homodimer-homodimer interface [polypeptide binding]; other site
394221006534	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
394221006535	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
394221006536	flagellin; Reviewed; Region: PRK12687
394221006537	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
394221006538	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
394221006539	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
394221006540	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
394221006541	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
394221006542	metal ion-dependent adhesion site (MIDAS); other site
394221006543	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
394221006544	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
394221006545	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
394221006546	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
394221006547	active site
394221006548	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
394221006549	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
394221006550	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
394221006551	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
394221006552	ATP binding site [chemical binding]; other site
394221006553	putative Mg++ binding site [ion binding]; other site
394221006554	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
394221006555	nucleotide binding region [chemical binding]; other site
394221006556	ATP-binding site [chemical binding]; other site
394221006557	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
394221006558	RNA binding surface [nucleotide binding]; other site
394221006559	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
394221006560	putative metal binding site [ion binding]; other site
394221006561	Ferredoxin [Energy production and conversion]; Region: COG1146
394221006562	4Fe-4S binding domain; Region: Fer4; pfam00037
394221006563	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
394221006564	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
394221006565	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
394221006566	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
394221006567	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
394221006568	DNA binding residues [nucleotide binding]
394221006569	Staphylococcal nuclease homologues; Region: SNc; smart00318
394221006570	Catalytic site; other site
394221006571	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
394221006572	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
394221006573	dimer interface [polypeptide binding]; other site
394221006574	putative CheW interface [polypeptide binding]; other site
394221006575	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
394221006576	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
394221006577	Tetratricopeptide repeat; Region: TPR_12; pfam13424
394221006578	Tetratricopeptide repeat; Region: TPR_12; pfam13424
394221006579	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221006580	binding surface
394221006581	TPR motif; other site
394221006582	Tetratricopeptide repeat; Region: TPR_12; pfam13424
394221006583	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
394221006584	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
394221006585	catalytic triad [active]
394221006586	putative active site [active]
394221006587	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
394221006588	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
394221006589	putative NAD(P) binding site [chemical binding]; other site
394221006590	putative substrate binding site [chemical binding]; other site
394221006591	catalytic Zn binding site [ion binding]; other site
394221006592	structural Zn binding site [ion binding]; other site
394221006593	dimer interface [polypeptide binding]; other site
394221006594	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
394221006595	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
394221006596	Uncharacterized conserved protein [Function unknown]; Region: COG0397
394221006597	hypothetical protein; Validated; Region: PRK00029
394221006598	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
394221006599	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
394221006600	substrate binding pocket [chemical binding]; other site
394221006601	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
394221006602	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
394221006603	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
394221006604	acyl-activating enzyme (AAE) consensus motif; other site
394221006605	putative AMP binding site [chemical binding]; other site
394221006606	putative active site [active]
394221006607	putative CoA binding site [chemical binding]; other site
394221006608	Protein of unknown function, DUF417; Region: DUF417; cl01162
394221006609	Protein of unknown function, DUF417; Region: DUF417; cl01162
394221006610	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
394221006611	active site
394221006612	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
394221006613	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
394221006614	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
394221006615	Fic family protein [Function unknown]; Region: COG3177
394221006616	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
394221006617	Fic/DOC family; Region: Fic; pfam02661
394221006618	Helix-turn-helix domain; Region: HTH_18; pfam12833
394221006619	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
394221006620	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
394221006621	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
394221006622	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
394221006623	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
394221006624	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221006625	Outer membrane efflux protein; Region: OEP; pfam02321
394221006626	Outer membrane efflux protein; Region: OEP; pfam02321
394221006627	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
394221006628	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
394221006629	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
394221006630	DNA binding residues [nucleotide binding]
394221006631	dimer interface [polypeptide binding]; other site
394221006632	putative metal binding site [ion binding]; other site
394221006633	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
394221006634	DNA binding residues [nucleotide binding]
394221006635	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
394221006636	dimer interface [polypeptide binding]; other site
394221006637	putative metal binding site [ion binding]; other site
394221006638	MerT mercuric transport protein; Region: MerT; cl03578
394221006639	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
394221006640	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
394221006641	metal-binding site [ion binding]
394221006642	mercuric reductase; Region: MerA; TIGR02053
394221006643	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
394221006644	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
394221006645	alkylmercury lyase; Provisional; Region: PRK13239
394221006646	Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324
394221006647	Alkylmercury lyase; Region: MerB; pfam03243
394221006648	Phospholipid methyltransferase; Region: PEMT; pfam04191
394221006649	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
394221006650	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
394221006651	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
394221006652	DNA binding residues [nucleotide binding]
394221006653	dimer interface [polypeptide binding]; other site
394221006654	putative metal binding site [ion binding]; other site
394221006655	lipoprotein signal peptidase; Provisional; Region: PRK14787
394221006656	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
394221006657	Domain of unknown function DUF302; Region: DUF302; pfam03625
394221006658	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
394221006659	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
394221006660	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
394221006661	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
394221006662	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221006663	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
394221006664	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
394221006665	active site
394221006666	catalytic residues [active]
394221006667	DNA binding site [nucleotide binding]
394221006668	Int/Topo IB signature motif; other site
394221006669	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
394221006670	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
394221006671	Walker A motif; other site
394221006672	ATP binding site [chemical binding]; other site
394221006673	Walker B motif; other site
394221006674	Antirestriction protein (ArdA); Region: ArdA; pfam07275
394221006675	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
394221006676	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
394221006677	active site
394221006678	catalytic residues [active]
394221006679	DNA binding site [nucleotide binding]
394221006680	Int/Topo IB signature motif; other site
394221006681	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
394221006682	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
394221006683	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
394221006684	diiron binding motif [ion binding]; other site
394221006685	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
394221006686	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
394221006687	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
394221006688	active site
394221006689	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
394221006690	putative hydrolase; Provisional; Region: PRK11460
394221006691	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
394221006692	GIY-YIG motif/motif A; other site
394221006693	putative active site [active]
394221006694	putative metal binding site [ion binding]; other site
394221006695	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
394221006696	active site
394221006697	HIGH motif; other site
394221006698	nucleotide binding site [chemical binding]; other site
394221006699	active site
394221006700	KMSKS motif; other site
394221006701	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
394221006702	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
394221006703	[2Fe-2S] cluster binding site [ion binding]; other site
394221006704	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
394221006705	hydrophobic ligand binding site; other site
394221006706	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221006707	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221006708	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
394221006709	YceI-like domain; Region: YceI; pfam04264
394221006710	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221006711	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221006712	Predicted transcriptional regulators [Transcription]; Region: COG1695
394221006713	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
394221006714	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
394221006715	Ligand binding site [chemical binding]; other site
394221006716	Electron transfer flavoprotein domain; Region: ETF; pfam01012
394221006717	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
394221006718	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
394221006719	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
394221006720	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221006721	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221006722	Amidohydrolase; Region: Amidohydro_4; pfam13147
394221006723	active site
394221006724	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
394221006725	Phytase; Region: Phytase; cl17685
394221006726	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
394221006727	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
394221006728	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221006729	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221006730	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
394221006731	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
394221006732	catalytic residues [active]
394221006733	argininosuccinate lyase; Provisional; Region: PRK00855
394221006734	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
394221006735	active sites [active]
394221006736	tetramer interface [polypeptide binding]; other site
394221006737	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
394221006738	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
394221006739	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
394221006740	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
394221006741	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
394221006742	Walker A/P-loop; other site
394221006743	ATP binding site [chemical binding]; other site
394221006744	Q-loop/lid; other site
394221006745	ABC transporter signature motif; other site
394221006746	Walker B; other site
394221006747	D-loop; other site
394221006748	H-loop/switch region; other site
394221006749	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
394221006750	Uncharacterized conserved protein [Function unknown]; Region: COG1434
394221006751	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
394221006752	putative active site [active]
394221006753	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
394221006754	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
394221006755	putative acyl-acceptor binding pocket; other site
394221006756	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
394221006757	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
394221006758	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
394221006759	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
394221006760	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221006761	homodimer interface [polypeptide binding]; other site
394221006762	catalytic residue [active]
394221006763	Methyltransferase domain; Region: Methyltransf_23; pfam13489
394221006764	Methyltransferase domain; Region: Methyltransf_11; pfam08241
394221006765	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
394221006766	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
394221006767	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
394221006768	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
394221006769	NAD(P) binding site [chemical binding]; other site
394221006770	homotetramer interface [polypeptide binding]; other site
394221006771	homodimer interface [polypeptide binding]; other site
394221006772	active site
394221006773	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
394221006774	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
394221006775	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
394221006776	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
394221006777	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
394221006778	Ligand binding site; other site
394221006779	Putative Catalytic site; other site
394221006780	DXD motif; other site
394221006781	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
394221006782	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
394221006783	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
394221006784	active site
394221006785	catalytic residues [active]
394221006786	metal binding site [ion binding]; metal-binding site
394221006787	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
394221006788	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
394221006789	O-Antigen ligase; Region: Wzy_C; pfam04932
394221006790	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
394221006791	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
394221006792	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
394221006793	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
394221006794	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
394221006795	active site
394221006796	dimer interface [polypeptide binding]; other site
394221006797	motif 1; other site
394221006798	motif 2; other site
394221006799	motif 3; other site
394221006800	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
394221006801	anticodon binding site; other site
394221006802	Haemolytic domain; Region: Haemolytic; pfam01809
394221006803	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
394221006804	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
394221006805	trimerization site [polypeptide binding]; other site
394221006806	active site
394221006807	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
394221006808	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
394221006809	active site
394221006810	HIGH motif; other site
394221006811	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
394221006812	KMSKS motif; other site
394221006813	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
394221006814	tRNA binding surface [nucleotide binding]; other site
394221006815	anticodon binding site; other site
394221006816	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
394221006817	GTP cyclohydrolase I; Provisional; Region: PLN03044
394221006818	active site
394221006819	SCP-2 sterol transfer family; Region: SCP2; cl01225
394221006820	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
394221006821	Peptidase family U32; Region: Peptidase_U32; pfam01136
394221006822	putative protease; Provisional; Region: PRK15447
394221006823	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
394221006824	Chorismate mutase type II; Region: CM_2; smart00830
394221006825	PhoD-like phosphatase; Region: PhoD; pfam09423
394221006826	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
394221006827	putative active site [active]
394221006828	putative metal binding site [ion binding]; other site
394221006829	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
394221006830	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221006831	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221006832	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
394221006833	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
394221006834	RNA binding surface [nucleotide binding]; other site
394221006835	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
394221006836	active site
394221006837	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
394221006838	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
394221006839	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
394221006840	active site
394221006841	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
394221006842	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
394221006843	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
394221006844	C-terminal domain interface [polypeptide binding]; other site
394221006845	GSH binding site (G-site) [chemical binding]; other site
394221006846	dimer interface [polypeptide binding]; other site
394221006847	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
394221006848	N-terminal domain interface [polypeptide binding]; other site
394221006849	dimer interface [polypeptide binding]; other site
394221006850	substrate binding pocket (H-site) [chemical binding]; other site
394221006851	dihydropteroate synthase; Region: DHPS; TIGR01496
394221006852	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
394221006853	substrate binding pocket [chemical binding]; other site
394221006854	dimer interface [polypeptide binding]; other site
394221006855	inhibitor binding site; inhibition site
394221006856	FtsH Extracellular; Region: FtsH_ext; pfam06480
394221006857	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
394221006858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221006859	Walker A motif; other site
394221006860	ATP binding site [chemical binding]; other site
394221006861	Walker B motif; other site
394221006862	arginine finger; other site
394221006863	Peptidase family M41; Region: Peptidase_M41; pfam01434
394221006864	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
394221006865	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
394221006866	Ligand Binding Site [chemical binding]; other site
394221006867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
394221006868	Tetratricopeptide repeat; Region: TPR_6; pfam13174
394221006869	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
394221006870	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
394221006871	ligand binding site [chemical binding]; other site
394221006872	translocation protein TolB; Provisional; Region: tolB; PRK05137
394221006873	TolB amino-terminal domain; Region: TolB_N; pfam04052
394221006874	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
394221006875	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
394221006876	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
394221006877	TolR protein; Region: tolR; TIGR02801
394221006878	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
394221006879	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
394221006880	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
394221006881	active site
394221006882	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
394221006883	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221006884	Walker A motif; other site
394221006885	ATP binding site [chemical binding]; other site
394221006886	Walker B motif; other site
394221006887	arginine finger; other site
394221006888	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
394221006889	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
394221006890	RuvA N terminal domain; Region: RuvA_N; pfam01330
394221006891	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
394221006892	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
394221006893	active site
394221006894	putative DNA-binding cleft [nucleotide binding]; other site
394221006895	dimer interface [polypeptide binding]; other site
394221006896	Cupin superfamily protein; Region: Cupin_4; pfam08007
394221006897	Cupin-like domain; Region: Cupin_8; pfam13621
394221006898	Strictosidine synthase; Region: Str_synth; pfam03088
394221006899	Arylesterase; Region: Arylesterase; pfam01731
394221006900	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
394221006901	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
394221006902	TPP-binding site [chemical binding]; other site
394221006903	dimer interface [polypeptide binding]; other site
394221006904	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
394221006905	PYR/PP interface [polypeptide binding]; other site
394221006906	dimer interface [polypeptide binding]; other site
394221006907	TPP binding site [chemical binding]; other site
394221006908	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
394221006909	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
394221006910	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
394221006911	active site
394221006912	dimer interface [polypeptide binding]; other site
394221006913	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
394221006914	dimer interface [polypeptide binding]; other site
394221006915	active site
394221006916	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
394221006917	dimerization interface [polypeptide binding]; other site
394221006918	putative active cleft [active]
394221006919	hypothetical protein; Validated; Region: PRK00110
394221006920	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
394221006921	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
394221006922	Substrate binding site; other site
394221006923	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
394221006924	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
394221006925	putative active site [active]
394221006926	metal binding site [ion binding]; metal-binding site
394221006927	homodimer binding site [polypeptide binding]; other site
394221006928	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
394221006929	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
394221006930	substrate binding pocket [chemical binding]; other site
394221006931	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
394221006932	B12 binding site [chemical binding]; other site
394221006933	cobalt ligand [ion binding]; other site
394221006934	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
394221006935	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
394221006936	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
394221006937	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
394221006938	FAD binding site [chemical binding]; other site
394221006939	S-adenosylmethionine synthetase; Validated; Region: PRK05250
394221006940	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
394221006941	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
394221006942	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
394221006943	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
394221006944	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
394221006945	homotetramer interface [polypeptide binding]; other site
394221006946	ligand binding site [chemical binding]; other site
394221006947	catalytic site [active]
394221006948	NAD binding site [chemical binding]; other site
394221006949	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
394221006950	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
394221006951	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
394221006952	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
394221006953	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
394221006954	Probable Catalytic site; other site
394221006955	metal-binding site
394221006956	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
394221006957	TrkA-C domain; Region: TrkA_C; pfam02080
394221006958	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
394221006959	TrkA-C domain; Region: TrkA_C; pfam02080
394221006960	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
394221006961	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
394221006962	active site
394221006963	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
394221006964	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
394221006965	CysD dimerization site [polypeptide binding]; other site
394221006966	G1 box; other site
394221006967	putative GEF interaction site [polypeptide binding]; other site
394221006968	GTP/Mg2+ binding site [chemical binding]; other site
394221006969	Switch I region; other site
394221006970	G2 box; other site
394221006971	G3 box; other site
394221006972	Switch II region; other site
394221006973	G4 box; other site
394221006974	G5 box; other site
394221006975	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
394221006976	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
394221006977	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
394221006978	ligand-binding site [chemical binding]; other site
394221006979	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
394221006980	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
394221006981	Active Sites [active]
394221006982	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
394221006983	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
394221006984	inhibitor-cofactor binding pocket; inhibition site
394221006985	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221006986	catalytic residue [active]
394221006987	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
394221006988	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
394221006989	glutaminase active site [active]
394221006990	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
394221006991	dimer interface [polypeptide binding]; other site
394221006992	active site
394221006993	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
394221006994	dimer interface [polypeptide binding]; other site
394221006995	active site
394221006996	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
394221006997	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
394221006998	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
394221006999	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
394221007000	NADP binding site [chemical binding]; other site
394221007001	active site
394221007002	putative substrate binding site [chemical binding]; other site
394221007003	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
394221007004	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
394221007005	NAD binding site [chemical binding]; other site
394221007006	substrate binding site [chemical binding]; other site
394221007007	homodimer interface [polypeptide binding]; other site
394221007008	active site
394221007009	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
394221007010	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
394221007011	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
394221007012	substrate binding site; other site
394221007013	tetramer interface; other site
394221007014	Integrase core domain; Region: rve_3; pfam13683
394221007015	Transposase; Region: HTH_Tnp_1; pfam01527
394221007016	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
394221007017	Integrase core domain; Region: rve; pfam00665
394221007018	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
394221007019	active site
394221007020	catalytic site [active]
394221007021	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
394221007022	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
394221007023	motif II; other site
394221007024	GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183
394221007025	Ligand binding site; other site
394221007026	GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183
394221007027	Ligand binding site; other site
394221007028	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
394221007029	active site
394221007030	SnoaL-like domain; Region: SnoaL_2; pfam12680
394221007031	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221007032	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
394221007033	putative substrate binding region [chemical binding]; other site
394221007034	Transposase; Region: HTH_Tnp_1; cl17663
394221007035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
394221007036	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
394221007037	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
394221007038	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
394221007039	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
394221007040	Probable Catalytic site; other site
394221007041	metal-binding site
394221007042	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
394221007043	putative ligand binding site [chemical binding]; other site
394221007044	putative catalytic site [active]
394221007045	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
394221007046	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
394221007047	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
394221007048	Walker A/P-loop; other site
394221007049	ATP binding site [chemical binding]; other site
394221007050	Q-loop/lid; other site
394221007051	ABC transporter signature motif; other site
394221007052	Walker B; other site
394221007053	D-loop; other site
394221007054	H-loop/switch region; other site
394221007055	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
394221007056	ABC-2 type transporter; Region: ABC2_membrane; cl17235
394221007057	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
394221007058	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
394221007059	active site
394221007060	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
394221007061	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
394221007062	Transposase; Region: HTH_Tnp_1; cl17663
394221007063	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
394221007064	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
394221007065	active site
394221007066	substrate binding site [chemical binding]; other site
394221007067	metal binding site [ion binding]; metal-binding site
394221007068	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
394221007069	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
394221007070	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
394221007071	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
394221007072	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
394221007073	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
394221007074	active site
394221007075	substrate binding site [chemical binding]; other site
394221007076	metal binding site [ion binding]; metal-binding site
394221007077	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
394221007078	active site
394221007079	tetramer interface; other site
394221007080	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221007081	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
394221007082	NAD(P) binding site [chemical binding]; other site
394221007083	active site
394221007084	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
394221007085	Ca2+ binding site [ion binding]; other site
394221007086	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
394221007087	Ca2+ binding site [ion binding]; other site
394221007088	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
394221007089	Ca2+ binding site [ion binding]; other site
394221007090	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
394221007091	Ca2+ binding site [ion binding]; other site
394221007092	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
394221007093	Ca2+ binding site [ion binding]; other site
394221007094	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
394221007095	Ca2+ binding site [ion binding]; other site
394221007096	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
394221007097	Ca2+ binding site [ion binding]; other site
394221007098	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
394221007099	Ca2+ binding site [ion binding]; other site
394221007100	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
394221007101	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
394221007102	active site
394221007103	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
394221007104	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
394221007105	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221007106	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
394221007107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221007108	Walker A/P-loop; other site
394221007109	ATP binding site [chemical binding]; other site
394221007110	Q-loop/lid; other site
394221007111	ABC transporter signature motif; other site
394221007112	Walker B; other site
394221007113	D-loop; other site
394221007114	H-loop/switch region; other site
394221007115	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
394221007116	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
394221007117	putative active site [active]
394221007118	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
394221007119	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
394221007120	catalytic core [active]
394221007121	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
394221007122	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
394221007123	catalytic motif [active]
394221007124	Zn binding site [ion binding]; other site
394221007125	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
394221007126	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221007127	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221007128	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
394221007129	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221007130	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221007131	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
394221007132	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
394221007133	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
394221007134	putative dimer interface [polypeptide binding]; other site
394221007135	Predicted methyltransferase [General function prediction only]; Region: COG4798
394221007136	Methyltransferase domain; Region: Methyltransf_23; pfam13489
394221007137	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
394221007138	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
394221007139	active site
394221007140	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221007141	sequence-specific DNA binding site [nucleotide binding]; other site
394221007142	salt bridge; other site
394221007143	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
394221007144	Response regulator receiver domain; Region: Response_reg; pfam00072
394221007145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221007146	active site
394221007147	phosphorylation site [posttranslational modification]
394221007148	intermolecular recognition site; other site
394221007149	dimerization interface [polypeptide binding]; other site
394221007150	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
394221007151	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221007152	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221007153	Stf0 sulphotransferase; Region: Sulphotransf; pfam09037
394221007154	Domain of unknown function DUF59; Region: DUF59; pfam01883
394221007155	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
394221007156	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
394221007157	Walker A motif; other site
394221007158	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
394221007159	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221007160	Walker A/P-loop; other site
394221007161	ATP binding site [chemical binding]; other site
394221007162	Q-loop/lid; other site
394221007163	ABC transporter signature motif; other site
394221007164	Walker B; other site
394221007165	D-loop; other site
394221007166	H-loop/switch region; other site
394221007167	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
394221007168	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
394221007169	ABC-ATPase subunit  interface; other site
394221007170	dimer interface [polypeptide binding]; other site
394221007171	putative PBP binding regions; other site
394221007172	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
394221007173	intersubunit interface [polypeptide binding]; other site
394221007174	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
394221007175	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
394221007176	N-terminal plug; other site
394221007177	ligand-binding site [chemical binding]; other site
394221007178	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
394221007179	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
394221007180	Uncharacterized conserved protein [Function unknown]; Region: COG4121
394221007181	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
394221007182	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
394221007183	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
394221007184	flagellar motor protein MotA; Validated; Region: PRK09110
394221007185	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
394221007186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221007187	Major Facilitator Superfamily; Region: MFS_1; pfam07690
394221007188	putative substrate translocation pore; other site
394221007189	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
394221007190	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221007191	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221007192	dimer interface [polypeptide binding]; other site
394221007193	phosphorylation site [posttranslational modification]
394221007194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221007195	ATP binding site [chemical binding]; other site
394221007196	Mg2+ binding site [ion binding]; other site
394221007197	G-X-G motif; other site
394221007198	Response regulator receiver domain; Region: Response_reg; pfam00072
394221007199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221007200	active site
394221007201	phosphorylation site [posttranslational modification]
394221007202	intermolecular recognition site; other site
394221007203	dimerization interface [polypeptide binding]; other site
394221007204	Transglycosylase SLT domain; Region: SLT_2; pfam13406
394221007205	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
394221007206	N-acetyl-D-glucosamine binding site [chemical binding]; other site
394221007207	catalytic residue [active]
394221007208	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
394221007209	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
394221007210	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
394221007211	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
394221007212	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
394221007213	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
394221007214	putative active site [active]
394221007215	metal binding site [ion binding]; metal-binding site
394221007216	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
394221007217	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
394221007218	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
394221007219	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
394221007220	motif II; other site
394221007221	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
394221007222	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
394221007223	active site
394221007224	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
394221007225	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
394221007226	active site
394221007227	MASE1; Region: MASE1; cl17823
394221007228	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221007229	PAS domain; Region: PAS_9; pfam13426
394221007230	putative active site [active]
394221007231	heme pocket [chemical binding]; other site
394221007232	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221007233	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221007234	dimer interface [polypeptide binding]; other site
394221007235	phosphorylation site [posttranslational modification]
394221007236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221007237	ATP binding site [chemical binding]; other site
394221007238	Mg2+ binding site [ion binding]; other site
394221007239	G-X-G motif; other site
394221007240	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221007241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221007242	active site
394221007243	phosphorylation site [posttranslational modification]
394221007244	intermolecular recognition site; other site
394221007245	dimerization interface [polypeptide binding]; other site
394221007246	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
394221007247	TPR motif; other site
394221007248	binding surface
394221007249	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
394221007250	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
394221007251	catalytic site [active]
394221007252	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
394221007253	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
394221007254	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
394221007255	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221007256	active site
394221007257	phosphorylation site [posttranslational modification]
394221007258	intermolecular recognition site; other site
394221007259	dimerization interface [polypeptide binding]; other site
394221007260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221007261	Walker A motif; other site
394221007262	ATP binding site [chemical binding]; other site
394221007263	Walker B motif; other site
394221007264	arginine finger; other site
394221007265	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
394221007266	CAAX protease self-immunity; Region: Abi; pfam02517
394221007267	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
394221007268	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
394221007269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221007270	active site
394221007271	phosphorylation site [posttranslational modification]
394221007272	intermolecular recognition site; other site
394221007273	dimerization interface [polypeptide binding]; other site
394221007274	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
394221007275	DNA binding residues [nucleotide binding]
394221007276	dimerization interface [polypeptide binding]; other site
394221007277	Histidine kinase; Region: HisKA_3; pfam07730
394221007278	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
394221007279	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
394221007280	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
394221007281	ligand binding site [chemical binding]; other site
394221007282	homodimer interface [polypeptide binding]; other site
394221007283	NAD(P) binding site [chemical binding]; other site
394221007284	trimer interface B [polypeptide binding]; other site
394221007285	trimer interface A [polypeptide binding]; other site
394221007286	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
394221007287	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
394221007288	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
394221007289	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
394221007290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221007291	S-adenosylmethionine binding site [chemical binding]; other site
394221007292	Domain of unknown function (DUF4269); Region: DUF4269; pfam14091
394221007293	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
394221007294	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
394221007295	DinB family; Region: DinB; cl17821
394221007296	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
394221007297	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221007298	Walker A/P-loop; other site
394221007299	ATP binding site [chemical binding]; other site
394221007300	Q-loop/lid; other site
394221007301	ABC transporter signature motif; other site
394221007302	Walker B; other site
394221007303	D-loop; other site
394221007304	H-loop/switch region; other site
394221007305	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
394221007306	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
394221007307	Predicted transcriptional regulators [Transcription]; Region: COG1733
394221007308	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
394221007309	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
394221007310	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221007311	NAD(P) binding site [chemical binding]; other site
394221007312	active site
394221007313	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
394221007314	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
394221007315	putative catalytic residue [active]
394221007316	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
394221007317	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
394221007318	COQ9; Region: COQ9; pfam08511
394221007319	Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053
394221007320	diiron binding motif [ion binding]; other site
394221007321	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
394221007322	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
394221007323	active site
394221007324	metal binding site [ion binding]; metal-binding site
394221007325	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
394221007326	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
394221007327	NAD binding site [chemical binding]; other site
394221007328	ATP-grasp domain; Region: ATP-grasp; pfam02222
394221007329	AIR carboxylase; Region: AIRC; pfam00731
394221007330	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
394221007331	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
394221007332	metal binding site [ion binding]; metal-binding site
394221007333	active site
394221007334	I-site; other site
394221007335	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
394221007336	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
394221007337	Flavoprotein; Region: Flavoprotein; pfam02441
394221007338	Uncharacterized small protein [Function unknown]; Region: COG5570
394221007339	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221007340	binding surface
394221007341	TPR motif; other site
394221007342	TPR repeat; Region: TPR_11; pfam13414
394221007343	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221007344	binding surface
394221007345	TPR motif; other site
394221007346	TPR repeat; Region: TPR_11; pfam13414
394221007347	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
394221007348	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221007349	NAD(P) binding site [chemical binding]; other site
394221007350	active site
394221007351	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
394221007352	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
394221007353	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
394221007354	NAD(P) binding site [chemical binding]; other site
394221007355	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
394221007356	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
394221007357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221007358	non-specific DNA binding site [nucleotide binding]; other site
394221007359	salt bridge; other site
394221007360	sequence-specific DNA binding site [nucleotide binding]; other site
394221007361	PAS fold; Region: PAS; pfam00989
394221007362	Sensors of blue-light using FAD; Region: BLUF; smart01034
394221007363	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
394221007364	heme-binding site [chemical binding]; other site
394221007365	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
394221007366	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
394221007367	dimer interface [polypeptide binding]; other site
394221007368	putative CheW interface [polypeptide binding]; other site
394221007369	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
394221007370	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
394221007371	CcdB protein; Region: CcdB; cl03380
394221007372	hypothetical protein; Validated; Region: PRK09039
394221007373	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
394221007374	ligand binding site [chemical binding]; other site
394221007375	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
394221007376	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
394221007377	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
394221007378	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
394221007379	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
394221007380	active site
394221007381	dimerization interface [polypeptide binding]; other site
394221007382	elongation factor P; Validated; Region: PRK00529
394221007383	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
394221007384	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
394221007385	RNA binding site [nucleotide binding]; other site
394221007386	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
394221007387	RNA binding site [nucleotide binding]; other site
394221007388	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
394221007389	Sel1-like repeats; Region: SEL1; smart00671
394221007390	Sel1-like repeats; Region: SEL1; smart00671
394221007391	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
394221007392	thiamine phosphate binding site [chemical binding]; other site
394221007393	active site
394221007394	pyrophosphate binding site [ion binding]; other site
394221007395	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
394221007396	active site
394221007397	intersubunit interface [polypeptide binding]; other site
394221007398	catalytic residue [active]
394221007399	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
394221007400	Phosphoglycerate kinase; Region: PGK; pfam00162
394221007401	substrate binding site [chemical binding]; other site
394221007402	hinge regions; other site
394221007403	ADP binding site [chemical binding]; other site
394221007404	catalytic site [active]
394221007405	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
394221007406	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
394221007407	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
394221007408	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221007409	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
394221007410	NAD(P) binding site [chemical binding]; other site
394221007411	active site
394221007412	HipA N-terminal domain; Region: Couple_hipA; cl11853
394221007413	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
394221007414	HipA-like N-terminal domain; Region: HipA_N; pfam07805
394221007415	HipA-like C-terminal domain; Region: HipA_C; pfam07804
394221007416	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221007417	non-specific DNA binding site [nucleotide binding]; other site
394221007418	salt bridge; other site
394221007419	sequence-specific DNA binding site [nucleotide binding]; other site
394221007420	acetylornithine deacetylase; Provisional; Region: PRK07522
394221007421	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
394221007422	metal binding site [ion binding]; metal-binding site
394221007423	putative dimer interface [polypeptide binding]; other site
394221007424	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
394221007425	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
394221007426	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
394221007427	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
394221007428	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
394221007429	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
394221007430	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
394221007431	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
394221007432	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
394221007433	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
394221007434	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
394221007435	Walker A/P-loop; other site
394221007436	ATP binding site [chemical binding]; other site
394221007437	Q-loop/lid; other site
394221007438	ABC transporter signature motif; other site
394221007439	Walker B; other site
394221007440	D-loop; other site
394221007441	H-loop/switch region; other site
394221007442	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
394221007443	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
394221007444	Walker A/P-loop; other site
394221007445	ATP binding site [chemical binding]; other site
394221007446	Q-loop/lid; other site
394221007447	ABC transporter signature motif; other site
394221007448	Walker B; other site
394221007449	D-loop; other site
394221007450	H-loop/switch region; other site
394221007451	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
394221007452	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
394221007453	putative active site [active]
394221007454	heme pocket [chemical binding]; other site
394221007455	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
394221007456	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221007457	PAS fold; Region: PAS_3; pfam08447
394221007458	putative active site [active]
394221007459	heme pocket [chemical binding]; other site
394221007460	PAS fold; Region: PAS_3; pfam08447
394221007461	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221007462	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221007463	putative active site [active]
394221007464	heme pocket [chemical binding]; other site
394221007465	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221007466	dimer interface [polypeptide binding]; other site
394221007467	phosphorylation site [posttranslational modification]
394221007468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221007469	ATP binding site [chemical binding]; other site
394221007470	Mg2+ binding site [ion binding]; other site
394221007471	G-X-G motif; other site
394221007472	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
394221007473	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
394221007474	FtsX-like permease family; Region: FtsX; pfam02687
394221007475	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
394221007476	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
394221007477	Walker A/P-loop; other site
394221007478	ATP binding site [chemical binding]; other site
394221007479	Q-loop/lid; other site
394221007480	ABC transporter signature motif; other site
394221007481	Walker B; other site
394221007482	D-loop; other site
394221007483	H-loop/switch region; other site
394221007484	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
394221007485	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221007486	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
394221007487	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
394221007488	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
394221007489	PhnA protein; Region: PhnA; pfam03831
394221007490	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
394221007491	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
394221007492	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
394221007493	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
394221007494	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
394221007495	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
394221007496	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
394221007497	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
394221007498	NAD(P) binding site [chemical binding]; other site
394221007499	active site
394221007500	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221007501	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221007502	dimer interface [polypeptide binding]; other site
394221007503	phosphorylation site [posttranslational modification]
394221007504	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221007505	ATP binding site [chemical binding]; other site
394221007506	Mg2+ binding site [ion binding]; other site
394221007507	G-X-G motif; other site
394221007508	Response regulator receiver domain; Region: Response_reg; pfam00072
394221007509	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221007510	active site
394221007511	phosphorylation site [posttranslational modification]
394221007512	intermolecular recognition site; other site
394221007513	dimerization interface [polypeptide binding]; other site
394221007514	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
394221007515	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
394221007516	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
394221007517	homoserine O-acetyltransferase; Provisional; Region: PRK08775
394221007518	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
394221007519	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
394221007520	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
394221007521	homodimer interface [polypeptide binding]; other site
394221007522	substrate-cofactor binding pocket; other site
394221007523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221007524	catalytic residue [active]
394221007525	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
394221007526	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
394221007527	N- and C-terminal domain interface [polypeptide binding]; other site
394221007528	active site
394221007529	MgATP binding site [chemical binding]; other site
394221007530	catalytic site [active]
394221007531	metal binding site [ion binding]; metal-binding site
394221007532	glycerol binding site [chemical binding]; other site
394221007533	homotetramer interface [polypeptide binding]; other site
394221007534	homodimer interface [polypeptide binding]; other site
394221007535	FBP binding site [chemical binding]; other site
394221007536	protein IIAGlc interface [polypeptide binding]; other site
394221007537	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
394221007538	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
394221007539	Predicted flavoproteins [General function prediction only]; Region: COG2081
394221007540	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
394221007541	HlyD family secretion protein; Region: HlyD_3; pfam13437
394221007542	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
394221007543	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
394221007544	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
394221007545	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
394221007546	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
394221007547	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
394221007548	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
394221007549	Zn binding site [ion binding]; other site
394221007550	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
394221007551	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
394221007552	Walker A/P-loop; other site
394221007553	ATP binding site [chemical binding]; other site
394221007554	Q-loop/lid; other site
394221007555	ABC transporter signature motif; other site
394221007556	Walker B; other site
394221007557	D-loop; other site
394221007558	H-loop/switch region; other site
394221007559	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
394221007560	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
394221007561	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
394221007562	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
394221007563	putative active site [active]
394221007564	Zn binding site [ion binding]; other site
394221007565	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
394221007566	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
394221007567	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
394221007568	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
394221007569	ligand binding site [chemical binding]; other site
394221007570	flexible hinge region; other site
394221007571	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
394221007572	putative switch regulator; other site
394221007573	non-specific DNA interactions [nucleotide binding]; other site
394221007574	DNA binding site [nucleotide binding]
394221007575	sequence specific DNA binding site [nucleotide binding]; other site
394221007576	putative cAMP binding site [chemical binding]; other site
394221007577	cyclase homology domain; Region: CHD; cd07302
394221007578	nucleotidyl binding site; other site
394221007579	metal binding site [ion binding]; metal-binding site
394221007580	dimer interface [polypeptide binding]; other site
394221007581	TIR domain; Region: TIR_2; pfam13676
394221007582	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
394221007583	phosphogluconate dehydratase; Validated; Region: PRK09054
394221007584	6-phosphogluconate dehydratase; Region: edd; TIGR01196
394221007585	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
394221007586	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
394221007587	putative active site [active]
394221007588	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
394221007589	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
394221007590	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
394221007591	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
394221007592	HemN C-terminal domain; Region: HemN_C; pfam06969
394221007593	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
394221007594	Surface antigen; Region: Bac_surface_Ag; pfam01103
394221007595	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
394221007596	Family of unknown function (DUF490); Region: DUF490; pfam04357
394221007597	Mechanosensitive ion channel; Region: MS_channel; pfam00924
394221007598	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
394221007599	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
394221007600	Cl binding site [ion binding]; other site
394221007601	oligomer interface [polypeptide binding]; other site
394221007602	BCCT family transporter; Region: BCCT; pfam02028
394221007603	Tetratricopeptide repeat; Region: TPR_16; pfam13432
394221007604	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221007605	TPR motif; other site
394221007606	binding surface
394221007607	Tetratricopeptide repeat; Region: TPR_16; pfam13432
394221007608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221007609	binding surface
394221007610	TPR motif; other site
394221007611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221007612	binding surface
394221007613	TPR motif; other site
394221007614	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
394221007615	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221007616	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
394221007617	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221007618	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
394221007619	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221007620	putative DNA binding site [nucleotide binding]; other site
394221007621	putative Zn2+ binding site [ion binding]; other site
394221007622	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
394221007623	CoA-transferase family III; Region: CoA_transf_3; pfam02515
394221007624	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
394221007625	substrate binding site [chemical binding]; other site
394221007626	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
394221007627	oxyanion hole (OAH) forming residues; other site
394221007628	trimer interface [polypeptide binding]; other site
394221007629	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
394221007630	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
394221007631	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
394221007632	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
394221007633	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
394221007634	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
394221007635	acyl-activating enzyme (AAE) consensus motif; other site
394221007636	putative AMP binding site [chemical binding]; other site
394221007637	putative active site [active]
394221007638	putative CoA binding site [chemical binding]; other site
394221007639	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
394221007640	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
394221007641	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
394221007642	classical (c) SDRs; Region: SDR_c; cd05233
394221007643	NAD(P) binding site [chemical binding]; other site
394221007644	active site
394221007645	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
394221007646	Phosphotransferase enzyme family; Region: APH; pfam01636
394221007647	putative active site [active]
394221007648	putative substrate binding site [chemical binding]; other site
394221007649	ATP binding site [chemical binding]; other site
394221007650	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221007651	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
394221007652	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
394221007653	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
394221007654	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221007655	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
394221007656	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221007657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221007658	Major Facilitator Superfamily; Region: MFS_1; pfam07690
394221007659	putative substrate translocation pore; other site
394221007660	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
394221007661	DUF35 OB-fold domain; Region: DUF35; pfam01796
394221007662	acetyl-CoA acetyltransferase; Provisional; Region: PRK08142
394221007663	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
394221007664	active site
394221007665	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
394221007666	MFS/sugar transport protein; Region: MFS_2; pfam13347
394221007667	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
394221007668	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
394221007669	dimer interface [polypeptide binding]; other site
394221007670	active site
394221007671	acyl-CoA thioesterase II; Region: tesB; TIGR00189
394221007672	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
394221007673	active site
394221007674	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
394221007675	catalytic triad [active]
394221007676	dimer interface [polypeptide binding]; other site
394221007677	gamma-glutamyl kinase; Provisional; Region: PRK05429
394221007678	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
394221007679	nucleotide binding site [chemical binding]; other site
394221007680	homotetrameric interface [polypeptide binding]; other site
394221007681	putative phosphate binding site [ion binding]; other site
394221007682	putative allosteric binding site; other site
394221007683	PUA domain; Region: PUA; pfam01472
394221007684	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
394221007685	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
394221007686	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
394221007687	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
394221007688	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
394221007689	putative catalytic cysteine [active]
394221007690	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
394221007691	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
394221007692	Na binding site [ion binding]; other site
394221007693	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
394221007694	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
394221007695	active site
394221007696	intersubunit interface [polypeptide binding]; other site
394221007697	catalytic residue [active]
394221007698	glucokinase, proteobacterial type; Region: glk; TIGR00749
394221007699	Glucokinase; Region: Glucokinase; pfam02685
394221007700	short chain dehydrogenase; Provisional; Region: PRK06949
394221007701	classical (c) SDRs; Region: SDR_c; cd05233
394221007702	NAD(P) binding site [chemical binding]; other site
394221007703	active site
394221007704	RDD family; Region: RDD; pfam06271
394221007705	Integral membrane protein DUF95; Region: DUF95; pfam01944
394221007706	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
394221007707	Protein of unknown function DUF58; Region: DUF58; pfam01882
394221007708	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
394221007709	metal ion-dependent adhesion site (MIDAS); other site
394221007710	MoxR-like ATPases [General function prediction only]; Region: COG0714
394221007711	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221007712	Walker A motif; other site
394221007713	ATP binding site [chemical binding]; other site
394221007714	Walker B motif; other site
394221007715	arginine finger; other site
394221007716	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
394221007717	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221007718	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
394221007719	Amidohydrolase; Region: Amidohydro_4; pfam13147
394221007720	active site
394221007721	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
394221007722	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
394221007723	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
394221007724	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
394221007725	SLBB domain; Region: SLBB; pfam10531
394221007726	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
394221007727	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
394221007728	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
394221007729	catalytic loop [active]
394221007730	iron binding site [ion binding]; other site
394221007731	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
394221007732	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
394221007733	[4Fe-4S] binding site [ion binding]; other site
394221007734	molybdopterin cofactor binding site; other site
394221007735	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
394221007736	molybdopterin cofactor binding site; other site
394221007737	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
394221007738	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
394221007739	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
394221007740	heme binding site [chemical binding]; other site
394221007741	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
394221007742	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
394221007743	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
394221007744	acyl-activating enzyme (AAE) consensus motif; other site
394221007745	AMP binding site [chemical binding]; other site
394221007746	active site
394221007747	CoA binding site [chemical binding]; other site
394221007748	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
394221007749	homotrimer interaction site [polypeptide binding]; other site
394221007750	putative active site [active]
394221007751	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
394221007752	active site
394221007753	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
394221007754	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
394221007755	active site
394221007756	enoyl-CoA hydratase; Provisional; Region: PRK06688
394221007757	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
394221007758	substrate binding site [chemical binding]; other site
394221007759	oxyanion hole (OAH) forming residues; other site
394221007760	trimer interface [polypeptide binding]; other site
394221007761	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
394221007762	MarR family; Region: MarR_2; pfam12802
394221007763	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
394221007764	classical (c) SDRs; Region: SDR_c; cd05233
394221007765	NAD(P) binding site [chemical binding]; other site
394221007766	active site
394221007767	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
394221007768	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
394221007769	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
394221007770	active site
394221007771	FMN binding site [chemical binding]; other site
394221007772	substrate binding site [chemical binding]; other site
394221007773	homotetramer interface [polypeptide binding]; other site
394221007774	catalytic residue [active]
394221007775	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
394221007776	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
394221007777	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
394221007778	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
394221007779	Autotransporter beta-domain; Region: Autotransporter; smart00869
394221007780	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
394221007781	MFS/sugar transport protein; Region: MFS_2; pfam13347
394221007782	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221007783	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221007784	dimer interface [polypeptide binding]; other site
394221007785	phosphorylation site [posttranslational modification]
394221007786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221007787	ATP binding site [chemical binding]; other site
394221007788	Mg2+ binding site [ion binding]; other site
394221007789	G-X-G motif; other site
394221007790	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
394221007791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221007792	active site
394221007793	phosphorylation site [posttranslational modification]
394221007794	intermolecular recognition site; other site
394221007795	dimerization interface [polypeptide binding]; other site
394221007796	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
394221007797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221007798	active site
394221007799	phosphorylation site [posttranslational modification]
394221007800	intermolecular recognition site; other site
394221007801	dimerization interface [polypeptide binding]; other site
394221007802	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
394221007803	DNA binding residues [nucleotide binding]
394221007804	dimerization interface [polypeptide binding]; other site
394221007805	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
394221007806	active site clefts [active]
394221007807	zinc binding site [ion binding]; other site
394221007808	dimer interface [polypeptide binding]; other site
394221007809	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
394221007810	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
394221007811	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
394221007812	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
394221007813	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
394221007814	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
394221007815	[4Fe-4S] binding site [ion binding]; other site
394221007816	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
394221007817	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
394221007818	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
394221007819	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
394221007820	molybdopterin cofactor binding site; other site
394221007821	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
394221007822	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
394221007823	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221007824	putative substrate translocation pore; other site
394221007825	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
394221007826	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
394221007827	ligand binding site [chemical binding]; other site
394221007828	flexible hinge region; other site
394221007829	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
394221007830	putative switch regulator; other site
394221007831	non-specific DNA interactions [nucleotide binding]; other site
394221007832	DNA binding site [nucleotide binding]
394221007833	sequence specific DNA binding site [nucleotide binding]; other site
394221007834	putative cAMP binding site [chemical binding]; other site
394221007835	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
394221007836	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
394221007837	GTP binding site; other site
394221007838	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
394221007839	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
394221007840	FeS/SAM binding site; other site
394221007841	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
394221007842	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
394221007843	MoaE interaction surface [polypeptide binding]; other site
394221007844	MoeB interaction surface [polypeptide binding]; other site
394221007845	thiocarboxylated glycine; other site
394221007846	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
394221007847	MoaE homodimer interface [polypeptide binding]; other site
394221007848	MoaD interaction [polypeptide binding]; other site
394221007849	active site residues [active]
394221007850	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
394221007851	MPT binding site; other site
394221007852	trimer interface [polypeptide binding]; other site
394221007853	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
394221007854	trimer interface [polypeptide binding]; other site
394221007855	dimer interface [polypeptide binding]; other site
394221007856	putative active site [active]
394221007857	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
394221007858	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
394221007859	dimer interface [polypeptide binding]; other site
394221007860	putative functional site; other site
394221007861	putative MPT binding site; other site
394221007862	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
394221007863	Transcriptional regulators [Transcription]; Region: PurR; COG1609
394221007864	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
394221007865	DNA binding site [nucleotide binding]
394221007866	domain linker motif; other site
394221007867	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
394221007868	putative dimerization interface [polypeptide binding]; other site
394221007869	putative ligand binding site [chemical binding]; other site
394221007870	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
394221007871	MFS/sugar transport protein; Region: MFS_2; pfam13347
394221007872	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
394221007873	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221007874	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221007875	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
394221007876	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
394221007877	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
394221007878	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
394221007879	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
394221007880	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
394221007881	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
394221007882	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
394221007883	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
394221007884	fructuronate transporter; Provisional; Region: PRK10034; cl15264
394221007885	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
394221007886	Strictosidine synthase; Region: Str_synth; pfam03088
394221007887	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
394221007888	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
394221007889	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
394221007890	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
394221007891	ATP-binding site [chemical binding]; other site
394221007892	Gluconate-6-phosphate binding site [chemical binding]; other site
394221007893	Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325
394221007894	Na binding site [ion binding]; other site
394221007895	substrate binding site [chemical binding]; other site
394221007896	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
394221007897	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
394221007898	active site
394221007899	catalytic site [active]
394221007900	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
394221007901	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
394221007902	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
394221007903	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221007904	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
394221007905	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
394221007906	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
394221007907	active site
394221007908	catalytic site [active]
394221007909	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
394221007910	Transcriptional regulators [Transcription]; Region: PurR; COG1609
394221007911	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
394221007912	DNA binding site [nucleotide binding]
394221007913	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
394221007914	putative dimerization interface [polypeptide binding]; other site
394221007915	putative ligand binding site [chemical binding]; other site
394221007916	GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301
394221007917	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221007918	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
394221007919	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
394221007920	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
394221007921	active site
394221007922	catalytic site [active]
394221007923	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
394221007924	Putative esterase; Region: Esterase; pfam00756
394221007925	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
394221007926	Cupin-like domain; Region: Cupin_8; pfam13621
394221007927	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
394221007928	active site
394221007929	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
394221007930	catalytic tetrad [active]
394221007931	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
394221007932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221007933	active site
394221007934	phosphorylation site [posttranslational modification]
394221007935	intermolecular recognition site; other site
394221007936	dimerization interface [polypeptide binding]; other site
394221007937	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
394221007938	DNA binding residues [nucleotide binding]
394221007939	dimerization interface [polypeptide binding]; other site
394221007940	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
394221007941	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
394221007942	putative active site [active]
394221007943	heme pocket [chemical binding]; other site
394221007944	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221007945	dimer interface [polypeptide binding]; other site
394221007946	phosphorylation site [posttranslational modification]
394221007947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221007948	ATP binding site [chemical binding]; other site
394221007949	Mg2+ binding site [ion binding]; other site
394221007950	G-X-G motif; other site
394221007951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221007952	Response regulator receiver domain; Region: Response_reg; pfam00072
394221007953	active site
394221007954	phosphorylation site [posttranslational modification]
394221007955	intermolecular recognition site; other site
394221007956	dimerization interface [polypeptide binding]; other site
394221007957	Heme NO binding; Region: HNOB; pfam07700
394221007958	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
394221007959	Response regulator receiver domain; Region: Response_reg; pfam00072
394221007960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221007961	active site
394221007962	phosphorylation site [posttranslational modification]
394221007963	intermolecular recognition site; other site
394221007964	dimerization interface [polypeptide binding]; other site
394221007965	HEAT repeats; Region: HEAT_2; pfam13646
394221007966	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
394221007967	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
394221007968	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
394221007969	DXD motif; other site
394221007970	Transposase; Region: HTH_Tnp_1; pfam01527
394221007971	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
394221007972	DNA-binding interface [nucleotide binding]; DNA binding site
394221007973	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
394221007974	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
394221007975	NAD binding site [chemical binding]; other site
394221007976	homodimer interface [polypeptide binding]; other site
394221007977	active site
394221007978	substrate binding site [chemical binding]; other site
394221007979	Transposase; Region: HTH_Tnp_1; pfam01527
394221007980	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
394221007981	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
394221007982	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
394221007983	Methyltransferase domain; Region: Methyltransf_23; pfam13489
394221007984	Methyltransferase domain; Region: Methyltransf_12; pfam08242
394221007985	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
394221007986	Sel1-like repeats; Region: SEL1; smart00671
394221007987	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
394221007988	Sel1-like repeats; Region: SEL1; smart00671
394221007989	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
394221007990	Sel1-like repeats; Region: SEL1; smart00671
394221007991	Sel1-like repeats; Region: SEL1; smart00671
394221007992	Predicted permease; Region: DUF318; cl17795
394221007993	Family description; Region: VCBS; pfam13517
394221007994	Family description; Region: VCBS; pfam13517
394221007995	Family description; Region: VCBS; pfam13517
394221007996	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
394221007997	type II secretion system protein D; Region: type_II_gspD; TIGR02517
394221007998	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
394221007999	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
394221008000	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
394221008001	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
394221008002	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
394221008003	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
394221008004	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
394221008005	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
394221008006	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
394221008007	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
394221008008	Walker A motif; other site
394221008009	ATP binding site [chemical binding]; other site
394221008010	Walker B motif; other site
394221008011	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
394221008012	Autotransporter beta-domain; Region: Autotransporter; smart00869
394221008013	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
394221008014	Integrase core domain; Region: rve; pfam00665
394221008015	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
394221008016	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
394221008017	Uncharacterized conserved protein [Function unknown]; Region: COG3743
394221008018	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
394221008019	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
394221008020	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
394221008021	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
394221008022	Gram-negative bacterial tonB protein; Region: TonB; cl10048
394221008023	GTPase CgtA; Reviewed; Region: obgE; PRK12299
394221008024	GTP1/OBG; Region: GTP1_OBG; pfam01018
394221008025	Obg GTPase; Region: Obg; cd01898
394221008026	G1 box; other site
394221008027	GTP/Mg2+ binding site [chemical binding]; other site
394221008028	Switch I region; other site
394221008029	G2 box; other site
394221008030	G3 box; other site
394221008031	Switch II region; other site
394221008032	G4 box; other site
394221008033	G5 box; other site
394221008034	gamma-glutamyl kinase; Provisional; Region: PRK05429
394221008035	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
394221008036	nucleotide binding site [chemical binding]; other site
394221008037	homotetrameric interface [polypeptide binding]; other site
394221008038	putative phosphate binding site [ion binding]; other site
394221008039	putative allosteric binding site; other site
394221008040	PUA domain; Region: PUA; pfam01472
394221008041	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
394221008042	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
394221008043	active site
394221008044	(T/H)XGH motif; other site
394221008045	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
394221008046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
394221008047	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
394221008048	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
394221008049	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
394221008050	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
394221008051	Peptidase family M23; Region: Peptidase_M23; pfam01551
394221008052	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
394221008053	C-terminal peptidase (prc); Region: prc; TIGR00225
394221008054	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
394221008055	protein binding site [polypeptide binding]; other site
394221008056	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
394221008057	Catalytic dyad [active]
394221008058	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
394221008059	NodB motif; other site
394221008060	putative active site [active]
394221008061	putative catalytic site [active]
394221008062	Zn binding site [ion binding]; other site
394221008063	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
394221008064	putative active site [active]
394221008065	Ap4A binding site [chemical binding]; other site
394221008066	nudix motif; other site
394221008067	putative metal binding site [ion binding]; other site
394221008068	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
394221008069	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
394221008070	gamma subunit interface [polypeptide binding]; other site
394221008071	epsilon subunit interface [polypeptide binding]; other site
394221008072	LBP interface [polypeptide binding]; other site
394221008073	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
394221008074	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
394221008075	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
394221008076	alpha subunit interaction interface [polypeptide binding]; other site
394221008077	Walker A motif; other site
394221008078	ATP binding site [chemical binding]; other site
394221008079	Walker B motif; other site
394221008080	inhibitor binding site; inhibition site
394221008081	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
394221008082	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
394221008083	core domain interface [polypeptide binding]; other site
394221008084	delta subunit interface [polypeptide binding]; other site
394221008085	epsilon subunit interface [polypeptide binding]; other site
394221008086	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
394221008087	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
394221008088	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
394221008089	beta subunit interaction interface [polypeptide binding]; other site
394221008090	Walker A motif; other site
394221008091	ATP binding site [chemical binding]; other site
394221008092	Walker B motif; other site
394221008093	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
394221008094	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
394221008095	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
394221008096	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
394221008097	primosome assembly protein PriA; Validated; Region: PRK05580
394221008098	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
394221008099	ATP binding site [chemical binding]; other site
394221008100	putative Mg++ binding site [ion binding]; other site
394221008101	helicase superfamily c-terminal domain; Region: HELICc; smart00490
394221008102	Protein of unknown function, DUF484; Region: DUF484; cl17449
394221008103	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
394221008104	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
394221008105	active site
394221008106	DNA binding site [nucleotide binding]
394221008107	Int/Topo IB signature motif; other site
394221008108	Transcriptional regulators [Transcription]; Region: MarR; COG1846
394221008109	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221008110	putative DNA binding site [nucleotide binding]; other site
394221008111	putative Zn2+ binding site [ion binding]; other site
394221008112	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
394221008113	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
394221008114	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
394221008115	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
394221008116	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
394221008117	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
394221008118	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
394221008119	E3 interaction surface; other site
394221008120	lipoyl attachment site [posttranslational modification]; other site
394221008121	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
394221008122	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
394221008123	E3 interaction surface; other site
394221008124	lipoyl attachment site [posttranslational modification]; other site
394221008125	e3 binding domain; Region: E3_binding; pfam02817
394221008126	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
394221008127	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
394221008128	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
394221008129	TPP-binding site [chemical binding]; other site
394221008130	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
394221008131	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
394221008132	CoA binding domain; Region: CoA_binding; smart00881
394221008133	CoA-ligase; Region: Ligase_CoA; pfam00549
394221008134	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
394221008135	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
394221008136	CoA-ligase; Region: Ligase_CoA; pfam00549
394221008137	TQO small subunit DoxD; Region: DoxD; pfam04173
394221008138	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
394221008139	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
394221008140	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
394221008141	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
394221008142	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
394221008143	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
394221008144	Mg++ binding site [ion binding]; other site
394221008145	LytTr DNA-binding domain; Region: LytTR; pfam04397
394221008146	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
394221008147	TspO/MBR family; Region: TspO_MBR; pfam03073
394221008148	malate dehydrogenase; Reviewed; Region: PRK06223
394221008149	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
394221008150	NAD(P) binding site [chemical binding]; other site
394221008151	dimer interface [polypeptide binding]; other site
394221008152	tetramer (dimer of dimers) interface [polypeptide binding]; other site
394221008153	substrate binding site [chemical binding]; other site
394221008154	Helix-turn-helix domain; Region: HTH_18; pfam12833
394221008155	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
394221008156	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
394221008157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221008158	S-adenosylmethionine binding site [chemical binding]; other site
394221008159	Predicted ATPase [General function prediction only]; Region: COG1485
394221008160	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
394221008161	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
394221008162	active site
394221008163	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
394221008164	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
394221008165	putative active site [active]
394221008166	metal binding site [ion binding]; metal-binding site
394221008167	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
394221008168	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
394221008169	tetrameric interface [polypeptide binding]; other site
394221008170	NAD binding site [chemical binding]; other site
394221008171	catalytic residues [active]
394221008172	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
394221008173	active site
394221008174	Autotransporter beta-domain; Region: Autotransporter; smart00869
394221008175	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221008176	dimerization interface [polypeptide binding]; other site
394221008177	putative DNA binding site [nucleotide binding]; other site
394221008178	putative Zn2+ binding site [ion binding]; other site
394221008179	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
394221008180	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
394221008181	putative acyl-acceptor binding pocket; other site
394221008182	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
394221008183	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
394221008184	catalytic loop [active]
394221008185	iron binding site [ion binding]; other site
394221008186	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
394221008187	L-aspartate oxidase; Provisional; Region: PRK06175
394221008188	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
394221008189	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
394221008190	Iron-sulfur protein interface; other site
394221008191	proximal heme binding site [chemical binding]; other site
394221008192	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
394221008193	Iron-sulfur protein interface; other site
394221008194	proximal quinone binding site [chemical binding]; other site
394221008195	SdhD (CybS) interface [polypeptide binding]; other site
394221008196	proximal heme binding site [chemical binding]; other site
394221008197	short chain dehydrogenase; Provisional; Region: PRK06914
394221008198	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
394221008199	NADP binding site [chemical binding]; other site
394221008200	active site
394221008201	steroid binding site; other site
394221008202	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
394221008203	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
394221008204	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
394221008205	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
394221008206	FeS/SAM binding site; other site
394221008207	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
394221008208	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
394221008209	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
394221008210	P loop; other site
394221008211	GTP binding site [chemical binding]; other site
394221008212	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
394221008213	Intracellular septation protein A; Region: IspA; pfam04279
394221008214	Transcriptional regulators [Transcription]; Region: MarR; COG1846
394221008215	MarR family; Region: MarR_2; pfam12802
394221008216	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
394221008217	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
394221008218	heme exporter protein CcmC; Region: ccmC; TIGR01191
394221008219	CcmB protein; Region: CcmB; cl17444
394221008220	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
394221008221	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
394221008222	Walker A/P-loop; other site
394221008223	ATP binding site [chemical binding]; other site
394221008224	Q-loop/lid; other site
394221008225	ABC transporter signature motif; other site
394221008226	Walker B; other site
394221008227	D-loop; other site
394221008228	H-loop/switch region; other site
394221008229	aconitate hydratase; Validated; Region: PRK09277
394221008230	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
394221008231	substrate binding site [chemical binding]; other site
394221008232	ligand binding site [chemical binding]; other site
394221008233	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
394221008234	substrate binding site [chemical binding]; other site
394221008235	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
394221008236	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
394221008237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221008238	active site
394221008239	phosphorylation site [posttranslational modification]
394221008240	intermolecular recognition site; other site
394221008241	dimerization interface [polypeptide binding]; other site
394221008242	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
394221008243	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221008244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221008245	phosphorylation site [posttranslational modification]
394221008246	dimer interface [polypeptide binding]; other site
394221008247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221008248	ATP binding site [chemical binding]; other site
394221008249	Mg2+ binding site [ion binding]; other site
394221008250	G-X-G motif; other site
394221008251	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
394221008252	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
394221008253	Cu(I) binding site [ion binding]; other site
394221008254	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
394221008255	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
394221008256	Transglycosylase; Region: Transgly; pfam00912
394221008257	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
394221008258	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
394221008259	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
394221008260	TrkA-N domain; Region: TrkA_N; pfam02254
394221008261	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
394221008262	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
394221008263	active site
394221008264	catalytic site [active]
394221008265	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
394221008266	DNA-binding site [nucleotide binding]; DNA binding site
394221008267	RNA-binding motif; other site
394221008268	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
394221008269	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221008270	active site
394221008271	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
394221008272	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
394221008273	Predicted permeases [General function prediction only]; Region: RarD; COG2962
394221008274	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
394221008275	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
394221008276	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221008277	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221008278	pyridoxamine kinase; Validated; Region: PRK05756
394221008279	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
394221008280	substrate binding site [chemical binding]; other site
394221008281	ATP binding site [chemical binding]; other site
394221008282	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
394221008283	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
394221008284	ArsC family; Region: ArsC; pfam03960
394221008285	catalytic residues [active]
394221008286	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
394221008287	Predicted transcriptional regulators [Transcription]; Region: COG1510
394221008288	MarR family; Region: MarR_2; pfam12802
394221008289	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
394221008290	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
394221008291	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
394221008292	dimerization interface [polypeptide binding]; other site
394221008293	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
394221008294	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
394221008295	dimer interface [polypeptide binding]; other site
394221008296	decamer (pentamer of dimers) interface [polypeptide binding]; other site
394221008297	catalytic triad [active]
394221008298	peroxidatic and resolving cysteines [active]
394221008299	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
394221008300	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
394221008301	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
394221008302	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
394221008303	Protein of unknown function (DUF1475); Region: DUF1475; pfam07343
394221008304	signal recognition particle protein; Provisional; Region: PRK10867
394221008305	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
394221008306	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
394221008307	P loop; other site
394221008308	GTP binding site [chemical binding]; other site
394221008309	Signal peptide binding domain; Region: SRP_SPB; pfam02978
394221008310	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
394221008311	RimM N-terminal domain; Region: RimM; pfam01782
394221008312	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
394221008313	PRC-barrel domain; Region: PRC; pfam05239
394221008314	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
394221008315	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
394221008316	Tetratricopeptide repeat; Region: TPR_16; pfam13432
394221008317	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
394221008318	TPR motif; other site
394221008319	binding surface
394221008320	Tetratricopeptide repeat; Region: TPR_16; pfam13432
394221008321	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
394221008322	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
394221008323	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
394221008324	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
394221008325	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
394221008326	conserved cys residue [active]
394221008327	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221008328	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
394221008329	active site
394221008330	metal binding site [ion binding]; metal-binding site
394221008331	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
394221008332	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
394221008333	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
394221008334	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
394221008335	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
394221008336	Walker A/P-loop; other site
394221008337	ATP binding site [chemical binding]; other site
394221008338	Q-loop/lid; other site
394221008339	ABC transporter signature motif; other site
394221008340	Walker B; other site
394221008341	D-loop; other site
394221008342	H-loop/switch region; other site
394221008343	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
394221008344	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
394221008345	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
394221008346	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
394221008347	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
394221008348	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
394221008349	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
394221008350	Low molecular weight phosphatase family; Region: LMWPc; cd00115
394221008351	active site
394221008352	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
394221008353	catalytic core [active]
394221008354	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
394221008355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221008356	dimer interface [polypeptide binding]; other site
394221008357	phosphorylation site [posttranslational modification]
394221008358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221008359	ATP binding site [chemical binding]; other site
394221008360	Mg2+ binding site [ion binding]; other site
394221008361	G-X-G motif; other site
394221008362	argininosuccinate synthase; Provisional; Region: PRK13820
394221008363	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
394221008364	ANP binding site [chemical binding]; other site
394221008365	Substrate Binding Site II [chemical binding]; other site
394221008366	Substrate Binding Site I [chemical binding]; other site
394221008367	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
394221008368	Glutaminase; Region: Glutaminase; cl00907
394221008369	Predicted integral membrane protein [Function unknown]; Region: COG5658
394221008370	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
394221008371	SdpI/YhfL protein family; Region: SdpI; pfam13630
394221008372	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
394221008373	dimerization interface [polypeptide binding]; other site
394221008374	putative DNA binding site [nucleotide binding]; other site
394221008375	putative Zn2+ binding site [ion binding]; other site
394221008376	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
394221008377	active site
394221008378	dimer interface [polypeptide binding]; other site
394221008379	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
394221008380	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
394221008381	heat shock protein HtpX; Provisional; Region: PRK01345
394221008382	NusB family; Region: NusB; pfam01029
394221008383	16S rRNA methyltransferase B; Provisional; Region: PRK10901
394221008384	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221008385	S-adenosylmethionine binding site [chemical binding]; other site
394221008386	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
394221008387	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
394221008388	substrate binding site [chemical binding]; other site
394221008389	hexamer interface [polypeptide binding]; other site
394221008390	metal binding site [ion binding]; metal-binding site
394221008391	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
394221008392	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
394221008393	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
394221008394	NAD(P) binding site [chemical binding]; other site
394221008395	homodimer interface [polypeptide binding]; other site
394221008396	substrate binding site [chemical binding]; other site
394221008397	active site
394221008398	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
394221008399	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
394221008400	purine monophosphate binding site [chemical binding]; other site
394221008401	dimer interface [polypeptide binding]; other site
394221008402	putative catalytic residues [active]
394221008403	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
394221008404	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
394221008405	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
394221008406	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
394221008407	Isochorismatase family; Region: Isochorismatase; pfam00857
394221008408	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
394221008409	catalytic triad [active]
394221008410	conserved cis-peptide bond; other site
394221008411	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
394221008412	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
394221008413	Coenzyme A binding pocket [chemical binding]; other site
394221008414	Transcriptional regulator [Transcription]; Region: LysR; COG0583
394221008415	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
394221008416	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
394221008417	dimerization interface [polypeptide binding]; other site
394221008418	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221008419	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221008420	sequence-specific DNA binding site [nucleotide binding]; other site
394221008421	salt bridge; other site
394221008422	Cytochrome c; Region: Cytochrom_C; cl11414
394221008423	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
394221008424	putative deacylase active site [active]
394221008425	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
394221008426	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
394221008427	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
394221008428	binding surface
394221008429	TPR motif; other site
394221008430	Uncharacterized conserved protein [Function unknown]; Region: COG2835
394221008431	Protein of unknown function (DUF971); Region: DUF971; pfam06155
394221008432	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
394221008433	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
394221008434	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
394221008435	DsrE/DsrF-like family; Region: DrsE; pfam02635
394221008436	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
394221008437	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
394221008438	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
394221008439	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
394221008440	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
394221008441	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
394221008442	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
394221008443	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
394221008444	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
394221008445	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
394221008446	putative catalytic site [active]
394221008447	putative phosphate binding site [ion binding]; other site
394221008448	active site
394221008449	metal binding site A [ion binding]; metal-binding site
394221008450	DNA binding site [nucleotide binding]
394221008451	putative AP binding site [nucleotide binding]; other site
394221008452	putative metal binding site B [ion binding]; other site
394221008453	Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415
394221008454	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
394221008455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221008456	active site
394221008457	phosphorylation site [posttranslational modification]
394221008458	intermolecular recognition site; other site
394221008459	dimerization interface [polypeptide binding]; other site
394221008460	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
394221008461	DNA binding site [nucleotide binding]
394221008462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
394221008463	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
394221008464	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
394221008465	catalytic residue [active]
394221008466	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
394221008467	thiamine phosphate binding site [chemical binding]; other site
394221008468	active site
394221008469	pyrophosphate binding site [ion binding]; other site
394221008470	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
394221008471	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
394221008472	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
394221008473	HIGH motif; other site
394221008474	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
394221008475	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
394221008476	active site
394221008477	KMSKS motif; other site
394221008478	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
394221008479	tRNA binding surface [nucleotide binding]; other site
394221008480	Lipopolysaccharide-assembly; Region: LptE; pfam04390
394221008481	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
394221008482	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
394221008483	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
394221008484	ParB-like nuclease domain; Region: ParB; smart00470
394221008485	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
394221008486	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
394221008487	P-loop; other site
394221008488	Magnesium ion binding site [ion binding]; other site
394221008489	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
394221008490	Magnesium ion binding site [ion binding]; other site
394221008491	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
394221008492	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
394221008493	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
394221008494	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
394221008495	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
394221008496	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
394221008497	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
394221008498	trmE is a tRNA modification GTPase; Region: trmE; cd04164
394221008499	G1 box; other site
394221008500	GTP/Mg2+ binding site [chemical binding]; other site
394221008501	Switch I region; other site
394221008502	G2 box; other site
394221008503	Switch II region; other site
394221008504	G3 box; other site
394221008505	G4 box; other site
394221008506	G5 box; other site
394221008507	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
394221008508	LytTr DNA-binding domain; Region: LytTR; smart00850
394221008509	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
394221008510	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
394221008511	putative C-terminal domain interface [polypeptide binding]; other site
394221008512	putative GSH binding site (G-site) [chemical binding]; other site
394221008513	putative dimer interface [polypeptide binding]; other site
394221008514	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
394221008515	N-terminal domain interface [polypeptide binding]; other site
394221008516	dimer interface [polypeptide binding]; other site
394221008517	substrate binding pocket (H-site) [chemical binding]; other site
394221008518	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
394221008519	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
394221008520	putative active site [active]
394221008521	catalytic site [active]
394221008522	putative metal binding site [ion binding]; other site
394221008523	oligomer interface [polypeptide binding]; other site
394221008524	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
394221008525	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
394221008526	NADP binding site [chemical binding]; other site
394221008527	dimer interface [polypeptide binding]; other site
394221008528	transcription termination factor Rho; Provisional; Region: rho; PRK09376
394221008529	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
394221008530	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
394221008531	RNA binding site [nucleotide binding]; other site
394221008532	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
394221008533	multimer interface [polypeptide binding]; other site
394221008534	Walker A motif; other site
394221008535	ATP binding site [chemical binding]; other site
394221008536	Walker B motif; other site
394221008537	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
394221008538	Ferrochelatase; Region: Ferrochelatase; pfam00762
394221008539	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
394221008540	C-terminal domain interface [polypeptide binding]; other site
394221008541	active site
394221008542	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
394221008543	active site
394221008544	N-terminal domain interface [polypeptide binding]; other site
394221008545	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
394221008546	substrate binding site [chemical binding]; other site
394221008547	active site
394221008548	PEP synthetase regulatory protein; Provisional; Region: PRK05339
394221008549	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
394221008550	Maf-like protein; Provisional; Region: PRK14361
394221008551	active site
394221008552	dimer interface [polypeptide binding]; other site
394221008553	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
394221008554	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
394221008555	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
394221008556	shikimate binding site; other site
394221008557	NAD(P) binding site [chemical binding]; other site
394221008558	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
394221008559	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
394221008560	CoA-binding site [chemical binding]; other site
394221008561	ATP-binding [chemical binding]; other site
394221008562	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
394221008563	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
394221008564	active site
394221008565	catalytic site [active]
394221008566	substrate binding site [chemical binding]; other site
394221008567	Preprotein translocase subunit SecB; Region: SecB; pfam02556
394221008568	SecA binding site; other site
394221008569	Preprotein binding site; other site
394221008570	Tim44-like domain; Region: Tim44; pfam04280
394221008571	MltA specific insert domain; Region: MltA; smart00925
394221008572	3D domain; Region: 3D; pfam06725
394221008573	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
394221008574	Smr domain; Region: Smr; pfam01713
394221008575	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
394221008576	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221008577	Walker A motif; other site
394221008578	ATP binding site [chemical binding]; other site
394221008579	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
394221008580	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
394221008581	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
394221008582	putative metal binding site [ion binding]; other site
394221008583	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
394221008584	active site
394221008585	HslU subunit interaction site [polypeptide binding]; other site
394221008586	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
394221008587	dimerization interface [polypeptide binding]; other site
394221008588	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
394221008589	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
394221008590	metal binding site [ion binding]; metal-binding site
394221008591	active site
394221008592	I-site; other site
394221008593	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
394221008594	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
394221008595	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
394221008596	substrate binding site [chemical binding]; other site
394221008597	ATP binding site [chemical binding]; other site
394221008598	ATP-grasp domain; Region: ATP-grasp_4; cl17255
394221008599	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
394221008600	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
394221008601	minor groove reading motif; other site
394221008602	helix-hairpin-helix signature motif; other site
394221008603	substrate binding pocket [chemical binding]; other site
394221008604	active site
394221008605	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
394221008606	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
394221008607	Helix-turn-helix domain; Region: HTH_18; pfam12833
394221008608	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
394221008609	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
394221008610	DNA binding site [nucleotide binding]
394221008611	active site
394221008612	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
394221008613	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
394221008614	dimer interface [polypeptide binding]; other site
394221008615	active site
394221008616	metal binding site [ion binding]; metal-binding site
394221008617	glutathione binding site [chemical binding]; other site
394221008618	Predicted transcriptional regulator [Transcription]; Region: COG2378
394221008619	HTH domain; Region: HTH_11; pfam08279
394221008620	WYL domain; Region: WYL; pfam13280
394221008621	dihydrodipicolinate reductase; Provisional; Region: PRK00048
394221008622	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
394221008623	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
394221008624	chaperone protein DnaJ; Provisional; Region: PRK10767
394221008625	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
394221008626	HSP70 interaction site [polypeptide binding]; other site
394221008627	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
394221008628	substrate binding site [polypeptide binding]; other site
394221008629	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
394221008630	Zn binding sites [ion binding]; other site
394221008631	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
394221008632	dimer interface [polypeptide binding]; other site
394221008633	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
394221008634	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
394221008635	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
394221008636	nucleotide binding site [chemical binding]; other site
394221008637	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
394221008638	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
394221008639	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
394221008640	active site
394221008641	FMN binding site [chemical binding]; other site
394221008642	substrate binding site [chemical binding]; other site
394221008643	3Fe-4S cluster binding site [ion binding]; other site
394221008644	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
394221008645	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
394221008646	dimer interface [polypeptide binding]; other site
394221008647	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
394221008648	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
394221008649	ribonuclease PH; Reviewed; Region: rph; PRK00173
394221008650	Ribonuclease PH; Region: RNase_PH_bact; cd11362
394221008651	hexamer interface [polypeptide binding]; other site
394221008652	active site
394221008653	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
394221008654	Predicted transcriptional regulator [Transcription]; Region: COG3655
394221008655	non-specific DNA binding site [nucleotide binding]; other site
394221008656	salt bridge; other site
394221008657	sequence-specific DNA binding site [nucleotide binding]; other site
394221008658	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
394221008659	active site
394221008660	dimerization interface [polypeptide binding]; other site
394221008661	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
394221008662	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
394221008663	FeS/SAM binding site; other site
394221008664	HemN C-terminal domain; Region: HemN_C; pfam06969
394221008665	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
394221008666	putative ligand binding site [chemical binding]; other site
394221008667	Predicted methyltransferases [General function prediction only]; Region: COG0313
394221008668	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
394221008669	putative SAM binding site [chemical binding]; other site
394221008670	putative homodimer interface [polypeptide binding]; other site
394221008671	hypothetical protein; Reviewed; Region: PRK12497
394221008672	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
394221008673	BON domain; Region: BON; pfam04972
394221008674	BON domain; Region: BON; pfam04972
394221008675	glutathione synthetase; Provisional; Region: PRK05246
394221008676	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
394221008677	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
394221008678	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
394221008679	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
394221008680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221008681	Walker A motif; other site
394221008682	ATP binding site [chemical binding]; other site
394221008683	Walker B motif; other site
394221008684	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
394221008685	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
394221008686	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
394221008687	dimer interface [polypeptide binding]; other site
394221008688	phosphorylation site [posttranslational modification]
394221008689	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
394221008690	ATP binding site [chemical binding]; other site
394221008691	Mg2+ binding site [ion binding]; other site
394221008692	G-X-G motif; other site
394221008693	Response regulator receiver domain; Region: Response_reg; pfam00072
394221008694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
394221008695	active site
394221008696	phosphorylation site [posttranslational modification]
394221008697	intermolecular recognition site; other site
394221008698	dimerization interface [polypeptide binding]; other site
394221008699	muropeptide transporter; Validated; Region: ampG; cl17669
394221008700	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221008701	putative substrate translocation pore; other site
394221008702	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
394221008703	Malic enzyme, N-terminal domain; Region: malic; pfam00390
394221008704	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
394221008705	putative NAD(P) binding site [chemical binding]; other site
394221008706	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
394221008707	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
394221008708	MutS domain I; Region: MutS_I; pfam01624
394221008709	MutS domain II; Region: MutS_II; pfam05188
394221008710	MutS domain III; Region: MutS_III; pfam05192
394221008711	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
394221008712	Walker A/P-loop; other site
394221008713	ATP binding site [chemical binding]; other site
394221008714	Q-loop/lid; other site
394221008715	ABC transporter signature motif; other site
394221008716	Walker B; other site
394221008717	D-loop; other site
394221008718	H-loop/switch region; other site
394221008719	UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844
394221008720	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
394221008721	metal binding triad; other site
394221008722	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
394221008723	HD domain; Region: HD; pfam01966
394221008724	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
394221008725	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
394221008726	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
394221008727	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
394221008728	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
394221008729	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
394221008730	active site
394221008731	HIGH motif; other site
394221008732	dimer interface [polypeptide binding]; other site
394221008733	KMSKS motif; other site
394221008734	Protein of unknown function (DUF461); Region: DUF461; pfam04314
394221008735	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
394221008736	Ligand Binding Site [chemical binding]; other site
394221008737	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
394221008738	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
394221008739	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
394221008740	Glycoprotease family; Region: Peptidase_M22; pfam00814
394221008741	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
394221008742	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
394221008743	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
394221008744	metal binding site 2 [ion binding]; metal-binding site
394221008745	putative DNA binding helix; other site
394221008746	metal binding site 1 [ion binding]; metal-binding site
394221008747	dimer interface [polypeptide binding]; other site
394221008748	structural Zn2+ binding site [ion binding]; other site
394221008749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
394221008750	Major Facilitator Superfamily; Region: MFS_1; pfam07690
394221008751	putative substrate translocation pore; other site
394221008752	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
394221008753	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
394221008754	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
394221008755	FeS/SAM binding site; other site
394221008756	TRAM domain; Region: TRAM; cl01282
394221008757	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
394221008758	PhoH-like protein; Region: PhoH; pfam02562
394221008759	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
394221008760	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
394221008761	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
394221008762	Transporter associated domain; Region: CorC_HlyC; smart01091
394221008763	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
394221008764	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
394221008765	putative active site [active]
394221008766	catalytic triad [active]
394221008767	putative dimer interface [polypeptide binding]; other site
394221008768	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
394221008769	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
394221008770	non-specific DNA binding site [nucleotide binding]; other site
394221008771	salt bridge; other site
394221008772	sequence-specific DNA binding site [nucleotide binding]; other site
394221008773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221008774	S-adenosylmethionine binding site [chemical binding]; other site
394221008775	ribosome maturation protein RimP; Reviewed; Region: PRK00092
394221008776	hypothetical protein; Provisional; Region: PRK14641
394221008777	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
394221008778	putative oligomer interface [polypeptide binding]; other site
394221008779	putative RNA binding site [nucleotide binding]; other site
394221008780	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
394221008781	NusA N-terminal domain; Region: NusA_N; pfam08529
394221008782	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
394221008783	RNA binding site [nucleotide binding]; other site
394221008784	homodimer interface [polypeptide binding]; other site
394221008785	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
394221008786	G-X-X-G motif; other site
394221008787	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
394221008788	G-X-X-G motif; other site
394221008789	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
394221008790	hypothetical protein; Provisional; Region: PRK09190
394221008791	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
394221008792	putative RNA binding cleft [nucleotide binding]; other site
394221008793	translation initiation factor IF-2; Region: IF-2; TIGR00487
394221008794	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
394221008795	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
394221008796	G1 box; other site
394221008797	putative GEF interaction site [polypeptide binding]; other site
394221008798	GTP/Mg2+ binding site [chemical binding]; other site
394221008799	Switch I region; other site
394221008800	G2 box; other site
394221008801	G3 box; other site
394221008802	Switch II region; other site
394221008803	G4 box; other site
394221008804	G5 box; other site
394221008805	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
394221008806	Translation-initiation factor 2; Region: IF-2; pfam11987
394221008807	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
394221008808	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
394221008809	SnoaL-like domain; Region: SnoaL_2; pfam12680
394221008810	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
394221008811	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
394221008812	Beta-lactamase; Region: Beta-lactamase; pfam00144
394221008813	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
394221008814	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
394221008815	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
394221008816	RNA binding site [nucleotide binding]; other site
394221008817	active site
394221008818	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
394221008819	16S/18S rRNA binding site [nucleotide binding]; other site
394221008820	S13e-L30e interaction site [polypeptide binding]; other site
394221008821	25S rRNA binding site [nucleotide binding]; other site
394221008822	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
394221008823	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
394221008824	RNase E interface [polypeptide binding]; other site
394221008825	trimer interface [polypeptide binding]; other site
394221008826	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
394221008827	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
394221008828	RNase E interface [polypeptide binding]; other site
394221008829	trimer interface [polypeptide binding]; other site
394221008830	active site
394221008831	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
394221008832	putative nucleic acid binding region [nucleotide binding]; other site
394221008833	G-X-X-G motif; other site
394221008834	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
394221008835	RNA binding site [nucleotide binding]; other site
394221008836	domain interface; other site
394221008837	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
394221008838	LytTr DNA-binding domain; Region: LytTR; smart00850
394221008839	Acyltransferase family; Region: Acyl_transf_3; pfam01757
394221008840	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
394221008841	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
394221008842	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221008843	EcoRII C terminal; Region: EcoRII-C; pfam09019
394221008844	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
394221008845	additional DNA contacts [nucleotide binding]; other site
394221008846	mismatch recognition site; other site
394221008847	active site
394221008848	zinc binding site [ion binding]; other site
394221008849	DNA intercalation site [nucleotide binding]; other site
394221008850	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
394221008851	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
394221008852	cofactor binding site; other site
394221008853	DNA binding site [nucleotide binding]
394221008854	substrate interaction site [chemical binding]; other site
394221008855	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
394221008856	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
394221008857	NAD binding site [chemical binding]; other site
394221008858	homotetramer interface [polypeptide binding]; other site
394221008859	homodimer interface [polypeptide binding]; other site
394221008860	substrate binding site [chemical binding]; other site
394221008861	active site
394221008862	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
394221008863	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
394221008864	dimer interface [polypeptide binding]; other site
394221008865	active site
394221008866	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
394221008867	active site 1 [active]
394221008868	dimer interface [polypeptide binding]; other site
394221008869	active site 2 [active]
394221008870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
394221008871	Bacterial SH3 domain; Region: SH3_4; pfam06347
394221008872	Bacterial SH3 domain; Region: SH3_4; pfam06347
394221008873	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
394221008874	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
394221008875	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221008876	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
394221008877	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
394221008878	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
394221008879	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
394221008880	ATP binding site [chemical binding]; other site
394221008881	substrate interface [chemical binding]; other site
394221008882	PIF1-like helicase; Region: PIF1; pfam05970
394221008883	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
394221008884	Walker A motif; other site
394221008885	ATP binding site [chemical binding]; other site
394221008886	Walker B motif; other site
394221008887	Family description; Region: UvrD_C_2; pfam13538
394221008888	Helicase; Region: Herpes_Helicase; pfam02689
394221008889	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
394221008890	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
394221008891	dimer interface [polypeptide binding]; other site
394221008892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
394221008893	catalytic residue [active]
394221008894	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
394221008895	trimer interface [polypeptide binding]; other site
394221008896	active site
394221008897	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
394221008898	heme-binding site [chemical binding]; other site
394221008899	ABC1 family; Region: ABC1; cl17513
394221008900	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
394221008901	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
394221008902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
394221008903	S-adenosylmethionine binding site [chemical binding]; other site
394221008904	Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520
394221008905	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
394221008906	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
394221008907	DNA binding site [nucleotide binding]
394221008908	catalytic residue [active]
394221008909	H2TH interface [polypeptide binding]; other site
394221008910	putative catalytic residues [active]
394221008911	turnover-facilitating residue; other site
394221008912	intercalation triad [nucleotide binding]; other site
394221008913	8OG recognition residue [nucleotide binding]; other site
394221008914	putative reading head residues; other site
394221008915	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
394221008916	TraB family; Region: TraB; pfam01963
394221008917	enoyl-CoA hydratase; Provisional; Region: PRK05862
394221008918	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
394221008919	substrate binding site [chemical binding]; other site
394221008920	oxyanion hole (OAH) forming residues; other site
394221008921	trimer interface [polypeptide binding]; other site
394221008922	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239