-- dump date   	20140619_135646
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
443254000001	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
443254000002	DNA binding residues [nucleotide binding]
443254000003	Transcriptional Coactivator p15 (PC4); Region: PC4; pfam02229
443254000004	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
443254000005	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
443254000006	active site
443254000007	DNA binding site [nucleotide binding]
443254000008	Int/Topo IB signature motif; other site
443254000009	CHC2 zinc finger; Region: zf-CHC2; cl17510
443254000010	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
443254000011	active site
443254000012	metal binding site [ion binding]; metal-binding site
443254000013	interdomain interaction site; other site
443254000014	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
443254000015	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
443254000016	Walker A motif; other site
443254000017	ATP binding site [chemical binding]; other site
443254000018	Walker B motif; other site
443254000019	PemK-like protein; Region: PemK; pfam02452
443254000020	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14088
443254000021	DnaA N-terminal domain; Region: DnaA_N; pfam11638
443254000022	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254000023	Walker A motif; other site
443254000024	ATP binding site [chemical binding]; other site
443254000025	Walker B motif; other site
443254000026	arginine finger; other site
443254000027	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
443254000028	DnaA box-binding interface [nucleotide binding]; other site
443254000029	methionine sulfoxide reductase A; Provisional; Region: PRK14054
443254000030	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
443254000031	putative FMN binding site [chemical binding]; other site
443254000032	NADPH bind site [chemical binding]; other site
443254000033	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
443254000034	Active_site [active]
443254000035	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
443254000036	homotrimer interaction site [polypeptide binding]; other site
443254000037	zinc binding site [ion binding]; other site
443254000038	CDP-binding sites; other site
443254000039	DNA polymerase III subunit beta; Validated; Region: PRK05643
443254000040	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
443254000041	putative DNA binding surface [nucleotide binding]; other site
443254000042	dimer interface [polypeptide binding]; other site
443254000043	beta-clamp/clamp loader binding surface; other site
443254000044	beta-clamp/translesion DNA polymerase binding surface; other site
443254000045	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
443254000046	Glycerophosphodiester phosphodiesterase domain of Thermotoga maritime and similar proteins; Region: GDPD_TmGDE_like; cd08568
443254000047	putative active site [active]
443254000048	catalytic site [active]
443254000049	putative metal binding site [ion binding]; other site
443254000050	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
443254000051	dinuclear metal binding motif [ion binding]; other site
443254000052	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165
443254000053	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
443254000054	putative ligand binding site [chemical binding]; other site
443254000055	NAD binding site [chemical binding]; other site
443254000056	dimer interface [polypeptide binding]; other site
443254000057	putative catalytic site [active]
443254000058	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
443254000059	PhoH-like protein; Region: PhoH; pfam02562
443254000060	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
443254000061	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254000062	Zn2+ binding site [ion binding]; other site
443254000063	Mg2+ binding site [ion binding]; other site
443254000064	metal-binding heat shock protein; Provisional; Region: PRK00016
443254000065	Uncharacterized conserved protein [Function unknown]; Region: COG4198
443254000066	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
443254000067	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_3; cd09321
443254000068	gating phenylalanine in ion channel; other site
443254000069	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
443254000070	putative DNA binding site [nucleotide binding]; other site
443254000071	dimerization interface [polypeptide binding]; other site
443254000072	putative Zn2+ binding site [ion binding]; other site
443254000073	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
443254000074	CPxP  motif; other site
443254000075	Sulphur transport; Region: Sulf_transp; pfam04143
443254000076	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
443254000077	active site residue [active]
443254000078	DsrE/DsrF-like family; Region: DrsE; cl00672
443254000079	DsrE/DsrF-like family; Region: DrsE; cl00672
443254000080	DsrH like protein; Region: DsrH; cl17347
443254000081	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
443254000082	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
443254000083	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
443254000084	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
443254000085	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
443254000086	dimerization interface [polypeptide binding]; other site
443254000087	putative DNA binding site [nucleotide binding]; other site
443254000088	putative Zn2+ binding site [ion binding]; other site
443254000089	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
443254000090	CPxP  motif; other site
443254000091	DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489
443254000092	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
443254000093	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254000094	Zn2+ binding site [ion binding]; other site
443254000095	Mg2+ binding site [ion binding]; other site
443254000096	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
443254000097	putative hydrophobic ligand binding site [chemical binding]; other site
443254000098	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
443254000099	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
443254000100	tetramer interface [polypeptide binding]; other site
443254000101	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254000102	catalytic residue [active]
443254000103	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
443254000104	nudix motif; other site
443254000105	MutL protein; Region: MutL; pfam13941
443254000106	aspartate aminotransferase; Provisional; Region: PRK05764
443254000107	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
443254000108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254000109	homodimer interface [polypeptide binding]; other site
443254000110	catalytic residue [active]
443254000111	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
443254000112	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
443254000113	hinge; other site
443254000114	active site
443254000115	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
443254000116	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254000117	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254000118	metal binding site [ion binding]; metal-binding site
443254000119	active site
443254000120	I-site; other site
443254000121	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
443254000122	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
443254000123	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
443254000124	active site
443254000125	motif I; other site
443254000126	motif II; other site
443254000127	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
443254000128	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
443254000129	DNA helicase, putative; Region: TIGR00376
443254000130	AAA domain; Region: AAA_30; pfam13604
443254000131	AAA domain; Region: AAA_12; pfam13087
443254000132	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
443254000133	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
443254000134	dimer interface [polypeptide binding]; other site
443254000135	active site
443254000136	EDD domain protein, DegV family; Region: DegV; TIGR00762
443254000137	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
443254000138	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
443254000139	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
443254000140	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
443254000141	active site
443254000142	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
443254000143	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
443254000144	FMN binding site [chemical binding]; other site
443254000145	substrate binding site [chemical binding]; other site
443254000146	putative catalytic residue [active]
443254000147	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
443254000148	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
443254000149	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
443254000150	putative substrate binding pocket [chemical binding]; other site
443254000151	AC domain interface; other site
443254000152	catalytic triad [active]
443254000153	AB domain interface; other site
443254000154	interchain disulfide; other site
443254000155	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
443254000156	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
443254000157	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
443254000158	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
443254000159	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
443254000160	hinge; other site
443254000161	active site
443254000162	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
443254000163	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
443254000164	active site
443254000165	metal binding site [ion binding]; metal-binding site
443254000166	DNA binding site [nucleotide binding]
443254000167	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254000168	AAA domain; Region: AAA_23; pfam13476
443254000169	Walker A/P-loop; other site
443254000170	ATP binding site [chemical binding]; other site
443254000171	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254000172	ABC transporter signature motif; other site
443254000173	Walker B; other site
443254000174	D-loop; other site
443254000175	H-loop/switch region; other site
443254000176	PQQ-like domain; Region: PQQ_2; pfam13360
443254000177	PQQ-like domain; Region: PQQ_2; pfam13360
443254000178	YWTD domain; Region: YWTD; pfam13570
443254000179	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
443254000180	active site
443254000181	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
443254000182	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
443254000183	active site
443254000184	dimer interface [polypeptide binding]; other site
443254000185	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
443254000186	dimer interface [polypeptide binding]; other site
443254000187	active site
443254000188	dephospho-CoA kinase; Provisional; Region: coaE; PRK14731
443254000189	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
443254000190	CoA-binding site [chemical binding]; other site
443254000191	ATP-binding [chemical binding]; other site
443254000192	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
443254000193	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
443254000194	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
443254000195	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
443254000196	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
443254000197	CHASE2 domain; Region: CHASE2; pfam05226
443254000198	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
443254000199	cyclase homology domain; Region: CHD; cd07302
443254000200	nucleotidyl binding site; other site
443254000201	metal binding site [ion binding]; metal-binding site
443254000202	dimer interface [polypeptide binding]; other site
443254000203	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254000204	Zn2+ binding site [ion binding]; other site
443254000205	Mg2+ binding site [ion binding]; other site
443254000206	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
443254000207	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
443254000208	GAF domain; Region: GAF; pfam01590
443254000209	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254000210	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254000211	Zn2+ binding site [ion binding]; other site
443254000212	Mg2+ binding site [ion binding]; other site
443254000213	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14962
443254000214	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254000215	Walker A motif; other site
443254000216	ATP binding site [chemical binding]; other site
443254000217	Walker B motif; other site
443254000218	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
443254000219	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
443254000220	putative metal binding site; other site
443254000221	Tetratricopeptide repeat; Region: TPR_12; pfam13424
443254000222	ribosome recycling factor; Reviewed; Region: frr; PRK00083
443254000223	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
443254000224	hinge region; other site
443254000225	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
443254000226	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
443254000227	catalytic residue [active]
443254000228	putative FPP diphosphate  binding site; other site
443254000229	putative FPP binding hydrophobic cleft; other site
443254000230	dimer interface [polypeptide binding]; other site
443254000231	putative IPP diphosphate binding site; other site
443254000232	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
443254000233	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
443254000234	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
443254000235	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
443254000236	motif 1; other site
443254000237	active site
443254000238	motif 2; other site
443254000239	motif 3; other site
443254000240	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
443254000241	DHHA1 domain; Region: DHHA1; pfam02272
443254000242	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
443254000243	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
443254000244	transmembrane helices; other site
443254000245	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
443254000246	hypothetical protein; Reviewed; Region: PRK12497
443254000247	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
443254000248	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
443254000249	active site
443254000250	substrate binding site [chemical binding]; other site
443254000251	metal binding site [ion binding]; metal-binding site
443254000252	tRNA pseudouridine synthase ACD; Provisional; Region: PRK14586
443254000253	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
443254000254	dimerization interface 3.5A [polypeptide binding]; other site
443254000255	active site
443254000256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254000257	dimer interface [polypeptide binding]; other site
443254000258	conserved gate region; other site
443254000259	ABC-ATPase subunit interface; other site
443254000260	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
443254000261	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254000262	Walker A/P-loop; other site
443254000263	ATP binding site [chemical binding]; other site
443254000264	Q-loop/lid; other site
443254000265	ABC transporter signature motif; other site
443254000266	Walker B; other site
443254000267	D-loop; other site
443254000268	H-loop/switch region; other site
443254000269	NIL domain; Region: NIL; pfam09383
443254000270	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
443254000271	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
443254000272	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
443254000273	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
443254000274	putative active site [active]
443254000275	heme pocket [chemical binding]; other site
443254000276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254000277	Walker A motif; other site
443254000278	ATP binding site [chemical binding]; other site
443254000279	Walker B motif; other site
443254000280	arginine finger; other site
443254000281	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
443254000282	Radical SAM superfamily; Region: Radical_SAM; pfam04055
443254000283	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
443254000284	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
443254000285	NAD(P) binding site [chemical binding]; other site
443254000286	homotetramer interface [polypeptide binding]; other site
443254000287	homodimer interface [polypeptide binding]; other site
443254000288	active site
443254000289	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
443254000290	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254000291	Zn2+ binding site [ion binding]; other site
443254000292	Mg2+ binding site [ion binding]; other site
443254000293	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
443254000294	synthetase active site [active]
443254000295	NTP binding site [chemical binding]; other site
443254000296	metal binding site [ion binding]; metal-binding site
443254000297	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
443254000298	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
443254000299	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
443254000300	putative active site [active]
443254000301	dimerization interface [polypeptide binding]; other site
443254000302	putative tRNAtyr binding site [nucleotide binding]; other site
443254000303	DNA polymerase I; Provisional; Region: PRK05755
443254000304	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
443254000305	active site
443254000306	metal binding site 1 [ion binding]; metal-binding site
443254000307	putative 5' ssDNA interaction site; other site
443254000308	metal binding site 3; metal-binding site
443254000309	metal binding site 2 [ion binding]; metal-binding site
443254000310	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
443254000311	putative DNA binding site [nucleotide binding]; other site
443254000312	putative metal binding site [ion binding]; other site
443254000313	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
443254000314	active site
443254000315	catalytic site [active]
443254000316	substrate binding site [chemical binding]; other site
443254000317	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
443254000318	active site
443254000319	DNA binding site [nucleotide binding]
443254000320	catalytic site [active]
443254000321	transcription termination factor Rho; Provisional; Region: rho; PRK09376
443254000322	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
443254000323	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
443254000324	RNA binding site [nucleotide binding]; other site
443254000325	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
443254000326	Walker A motif; other site
443254000327	ATP binding site [chemical binding]; other site
443254000328	Walker B motif; other site
443254000329	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
443254000330	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
443254000331	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
443254000332	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254000333	dimerization interface [polypeptide binding]; other site
443254000334	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254000335	dimer interface [polypeptide binding]; other site
443254000336	putative CheW interface [polypeptide binding]; other site
443254000337	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
443254000338	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
443254000339	active site
443254000340	putative substrate binding pocket [chemical binding]; other site
443254000341	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
443254000342	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
443254000343	Rubrerythrin [Energy production and conversion]; Region: COG1592
443254000344	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
443254000345	binuclear metal center [ion binding]; other site
443254000346	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
443254000347	iron binding site [ion binding]; other site
443254000348	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172
443254000349	non-heme iron binding site [ion binding]; other site
443254000350	tetramer interface [polypeptide binding]; other site
443254000351	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
443254000352	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
443254000353	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254000354	FeS/SAM binding site; other site
443254000355	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
443254000356	biotin synthase; Provisional; Region: PRK07094
443254000357	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254000358	FeS/SAM binding site; other site
443254000359	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
443254000360	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
443254000361	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
443254000362	G1 box; other site
443254000363	GTP/Mg2+ binding site [chemical binding]; other site
443254000364	Switch I region; other site
443254000365	G2 box; other site
443254000366	Switch II region; other site
443254000367	G3 box; other site
443254000368	G4 box; other site
443254000369	G5 box; other site
443254000370	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
443254000371	Aspartase; Region: Aspartase; cd01357
443254000372	active sites [active]
443254000373	tetramer interface [polypeptide binding]; other site
443254000374	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
443254000375	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254000376	FeS/SAM binding site; other site
443254000377	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
443254000378	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
443254000379	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
443254000380	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
443254000381	bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional; Region: PRK13962
443254000382	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
443254000383	substrate binding site [chemical binding]; other site
443254000384	hinge regions; other site
443254000385	ADP binding site [chemical binding]; other site
443254000386	catalytic site [active]
443254000387	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
443254000388	substrate binding site [chemical binding]; other site
443254000389	dimer interface [polypeptide binding]; other site
443254000390	catalytic triad [active]
443254000391	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
443254000392	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
443254000393	Walker A/P-loop; other site
443254000394	ATP binding site [chemical binding]; other site
443254000395	Q-loop/lid; other site
443254000396	ABC transporter signature motif; other site
443254000397	Walker B; other site
443254000398	D-loop; other site
443254000399	H-loop/switch region; other site
443254000400	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
443254000401	RNA methyltransferase, RsmE family; Region: TIGR00046
443254000402	seryl-tRNA synthetase; Provisional; Region: PRK05431
443254000403	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
443254000404	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
443254000405	dimer interface [polypeptide binding]; other site
443254000406	active site
443254000407	motif 1; other site
443254000408	motif 2; other site
443254000409	motif 3; other site
443254000410	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
443254000411	Patatin-like phospholipase; Region: Patatin; pfam01734
443254000412	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
443254000413	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
443254000414	active site
443254000415	nucleophile elbow; other site
443254000416	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
443254000417	PEGA domain; Region: PEGA; pfam08308
443254000418	PEGA domain; Region: PEGA; pfam08308
443254000419	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
443254000420	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
443254000421	dimerization interface [polypeptide binding]; other site
443254000422	putative Zn2+ binding site [ion binding]; other site
443254000423	putative DNA binding site [nucleotide binding]; other site
443254000424	phosphoethanolamine transferase; Provisional; Region: PRK11560
443254000425	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
443254000426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254000427	S-adenosylmethionine binding site [chemical binding]; other site
443254000428	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
443254000429	putative homodimer interface [polypeptide binding]; other site
443254000430	putative active site pocket [active]
443254000431	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
443254000432	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
443254000433	non-specific DNA binding site [nucleotide binding]; other site
443254000434	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
443254000435	salt bridge; other site
443254000436	sequence-specific DNA binding site [nucleotide binding]; other site
443254000437	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
443254000438	Catalytic site [active]
443254000439	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
443254000440	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
443254000441	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
443254000442	active site
443254000443	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
443254000444	ScpA/B protein; Region: ScpA_ScpB; cl00598
443254000445	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
443254000446	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
443254000447	active site
443254000448	HIGH motif; other site
443254000449	dimer interface [polypeptide binding]; other site
443254000450	KMSKS motif; other site
443254000451	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
443254000452	tetramer interface [polypeptide binding]; other site
443254000453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254000454	catalytic residue [active]
443254000455	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
443254000456	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
443254000457	tetramer interface [polypeptide binding]; other site
443254000458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254000459	catalytic residue [active]
443254000460	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
443254000461	lipoyl attachment site [posttranslational modification]; other site
443254000462	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
443254000463	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
443254000464	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
443254000465	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
443254000466	6-phosphofructokinase; Provisional; Region: PRK03202
443254000467	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
443254000468	active site
443254000469	ADP/pyrophosphate binding site [chemical binding]; other site
443254000470	dimerization interface [polypeptide binding]; other site
443254000471	allosteric effector site; other site
443254000472	fructose-1,6-bisphosphate binding site; other site
443254000473	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
443254000474	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
443254000475	domain interfaces; other site
443254000476	active site
443254000477	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
443254000478	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
443254000479	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
443254000480	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
443254000481	Protein of unknown function (DUF401); Region: DUF401; cl00830
443254000482	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
443254000483	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
443254000484	dimer interface [polypeptide binding]; other site
443254000485	active site
443254000486	glycine-pyridoxal phosphate binding site [chemical binding]; other site
443254000487	folate binding site [chemical binding]; other site
443254000488	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
443254000489	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
443254000490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254000491	homodimer interface [polypeptide binding]; other site
443254000492	catalytic residue [active]
443254000493	butyrate kinase; Provisional; Region: PRK03011
443254000494	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
443254000495	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
443254000496	nucleotide binding site [chemical binding]; other site
443254000497	Acetokinase family; Region: Acetate_kinase; cl17229
443254000498	Ferredoxin [Energy production and conversion]; Region: COG1146
443254000499	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
443254000500	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
443254000501	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
443254000502	dimer interface [polypeptide binding]; other site
443254000503	PYR/PP interface [polypeptide binding]; other site
443254000504	TPP binding site [chemical binding]; other site
443254000505	substrate binding site [chemical binding]; other site
443254000506	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
443254000507	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
443254000508	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
443254000509	TPP-binding site [chemical binding]; other site
443254000510	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
443254000511	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
443254000512	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
443254000513	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
443254000514	Substrate-binding site [chemical binding]; other site
443254000515	Substrate specificity [chemical binding]; other site
443254000516	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
443254000517	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
443254000518	Substrate-binding site [chemical binding]; other site
443254000519	Substrate specificity [chemical binding]; other site
443254000520	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
443254000521	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
443254000522	DNA methylase; Region: N6_N4_Mtase; pfam01555
443254000523	DNA methylase; Region: N6_N4_Mtase; cl17433
443254000524	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
443254000525	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254000526	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
443254000527	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
443254000528	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254000529	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
443254000530	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
443254000531	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
443254000532	Part of AAA domain; Region: AAA_19; pfam13245
443254000533	Family description; Region: UvrD_C_2; pfam13538
443254000534	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
443254000535	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
443254000536	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
443254000537	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
443254000538	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
443254000539	purine nucleoside phosphorylase; Provisional; Region: PRK08202
443254000540	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
443254000541	DHH family; Region: DHH; pfam01368
443254000542	DHHA1 domain; Region: DHHA1; pfam02272
443254000543	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
443254000544	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
443254000545	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
443254000546	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
443254000547	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
443254000548	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
443254000549	substrate binding pocket [chemical binding]; other site
443254000550	membrane-bound complex binding site; other site
443254000551	hinge residues; other site
443254000552	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
443254000553	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
443254000554	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
443254000555	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
443254000556	structural tetrad; other site
443254000557	PQQ-like domain; Region: PQQ_2; pfam13360
443254000558	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
443254000559	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
443254000560	G1 box; other site
443254000561	GTP/Mg2+ binding site [chemical binding]; other site
443254000562	Switch I region; other site
443254000563	G2 box; other site
443254000564	G3 box; other site
443254000565	Switch II region; other site
443254000566	G4 box; other site
443254000567	G5 box; other site
443254000568	Nucleoside recognition; Region: Gate; pfam07670
443254000569	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
443254000570	Nucleoside recognition; Region: Gate; pfam07670
443254000571	FeoA domain; Region: FeoA; pfam04023
443254000572	O-Antigen ligase; Region: Wzy_C; pfam04932
443254000573	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
443254000574	EDD domain protein, DegV family; Region: DegV; TIGR00762
443254000575	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
443254000576	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
443254000577	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
443254000578	ssDNA binding site; other site
443254000579	generic binding surface II; other site
443254000580	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
443254000581	ATP binding site [chemical binding]; other site
443254000582	putative Mg++ binding site [ion binding]; other site
443254000583	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
443254000584	nucleotide binding region [chemical binding]; other site
443254000585	ATP-binding site [chemical binding]; other site
443254000586	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
443254000587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254000588	S-adenosylmethionine binding site [chemical binding]; other site
443254000589	Late competence development protein ComFB; Region: ComFB; pfam10719
443254000590	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
443254000591	FOG: CBS domain [General function prediction only]; Region: COG0517
443254000592	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
443254000593	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
443254000594	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
443254000595	active site
443254000596	NTP binding site [chemical binding]; other site
443254000597	metal binding triad [ion binding]; metal-binding site
443254000598	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
443254000599	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
443254000600	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
443254000601	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
443254000602	active site
443254000603	homodimer interface [polypeptide binding]; other site
443254000604	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
443254000605	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
443254000606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254000607	Walker A motif; other site
443254000608	ATP binding site [chemical binding]; other site
443254000609	Walker B motif; other site
443254000610	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
443254000611	UGMP family protein; Validated; Region: PRK09604
443254000612	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
443254000613	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
443254000614	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
443254000615	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
443254000616	FMN binding site [chemical binding]; other site
443254000617	active site
443254000618	catalytic residues [active]
443254000619	substrate binding site [chemical binding]; other site
443254000620	GAF domain; Region: GAF; pfam01590
443254000621	GAF domain; Region: GAF_2; pfam13185
443254000622	Response regulator receiver domain; Region: Response_reg; pfam00072
443254000623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254000624	active site
443254000625	phosphorylation site [posttranslational modification]
443254000626	intermolecular recognition site; other site
443254000627	dimerization interface [polypeptide binding]; other site
443254000628	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254000629	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
443254000630	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
443254000631	Walker A/P-loop; other site
443254000632	ATP binding site [chemical binding]; other site
443254000633	Q-loop/lid; other site
443254000634	ABC transporter signature motif; other site
443254000635	Walker B; other site
443254000636	D-loop; other site
443254000637	H-loop/switch region; other site
443254000638	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
443254000639	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254000640	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254000641	Walker A/P-loop; other site
443254000642	ATP binding site [chemical binding]; other site
443254000643	Q-loop/lid; other site
443254000644	ABC transporter signature motif; other site
443254000645	Walker B; other site
443254000646	D-loop; other site
443254000647	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
443254000648	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254000649	FeS/SAM binding site; other site
443254000650	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
443254000651	Archaeal ATPase; Region: Arch_ATPase; pfam01637
443254000652	AAA ATPase domain; Region: AAA_16; pfam13191
443254000653	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
443254000654	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
443254000655	A new structural DNA glycosylase; Region: AlkD_like; cd06561
443254000656	active site
443254000657	Archaeal ATPase; Region: Arch_ATPase; pfam01637
443254000658	AAA domain; Region: AAA_14; pfam13173
443254000659	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
443254000660	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
443254000661	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
443254000662	V-type ATP synthase subunit I; Validated; Region: PRK05771
443254000663	Response regulator receiver domain; Region: Response_reg; pfam00072
443254000664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254000665	active site
443254000666	phosphorylation site [posttranslational modification]
443254000667	intermolecular recognition site; other site
443254000668	dimerization interface [polypeptide binding]; other site
443254000669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254000670	ATP binding site [chemical binding]; other site
443254000671	Mg2+ binding site [ion binding]; other site
443254000672	G-X-G motif; other site
443254000673	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
443254000674	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254000675	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254000676	metal binding site [ion binding]; metal-binding site
443254000677	active site
443254000678	I-site; other site
443254000679	Cache domain; Region: Cache_1; pfam02743
443254000680	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
443254000681	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
443254000682	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
443254000683	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
443254000684	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
443254000685	nucleotide binding pocket [chemical binding]; other site
443254000686	K-X-D-G motif; other site
443254000687	catalytic site [active]
443254000688	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
443254000689	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
443254000690	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
443254000691	Dimer interface [polypeptide binding]; other site
443254000692	BRCT sequence motif; other site
443254000693	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
443254000694	MgtC family; Region: MgtC; pfam02308
443254000695	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
443254000696	Cell division protein FtsA; Region: FtsA; smart00842
443254000697	Cell division protein FtsA; Region: FtsA; pfam14450
443254000698	MutS domain III; Region: MutS_III; pfam05192
443254000699	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254000700	Walker A/P-loop; other site
443254000701	ATP binding site [chemical binding]; other site
443254000702	Q-loop/lid; other site
443254000703	ABC transporter signature motif; other site
443254000704	Walker B; other site
443254000705	D-loop; other site
443254000706	H-loop/switch region; other site
443254000707	Smr domain; Region: Smr; pfam01713
443254000708	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
443254000709	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
443254000710	TPP-binding site; other site
443254000711	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
443254000712	PYR/PP interface [polypeptide binding]; other site
443254000713	dimer interface [polypeptide binding]; other site
443254000714	TPP binding site [chemical binding]; other site
443254000715	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
443254000716	transcription antitermination factor NusB; Region: nusB; TIGR01951
443254000717	putative RNA binding site [nucleotide binding]; other site
443254000718	Asp23 family; Region: Asp23; pfam03780
443254000719	elongation factor P; Validated; Region: PRK00529
443254000720	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
443254000721	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
443254000722	RNA binding site [nucleotide binding]; other site
443254000723	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
443254000724	RNA binding site [nucleotide binding]; other site
443254000725	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
443254000726	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
443254000727	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
443254000728	active site
443254000729	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
443254000730	MutS domain I; Region: MutS_I; pfam01624
443254000731	MutS domain III; Region: MutS_III; pfam05192
443254000732	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
443254000733	Walker A/P-loop; other site
443254000734	ATP binding site [chemical binding]; other site
443254000735	Q-loop/lid; other site
443254000736	ABC transporter signature motif; other site
443254000737	Walker B; other site
443254000738	D-loop; other site
443254000739	H-loop/switch region; other site
443254000740	Clp protease; Region: CLP_protease; pfam00574
443254000741	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
443254000742	oligomer interface [polypeptide binding]; other site
443254000743	active site residues [active]
443254000744	Domain of unknown function (DUF370); Region: DUF370; cl00898
443254000745	GTPase CgtA; Reviewed; Region: obgE; PRK12297
443254000746	GTP1/OBG; Region: GTP1_OBG; pfam01018
443254000747	Obg GTPase; Region: Obg; cd01898
443254000748	G1 box; other site
443254000749	GTP/Mg2+ binding site [chemical binding]; other site
443254000750	Switch I region; other site
443254000751	G2 box; other site
443254000752	G3 box; other site
443254000753	Switch II region; other site
443254000754	G4 box; other site
443254000755	G5 box; other site
443254000756	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
443254000757	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
443254000758	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
443254000759	active site
443254000760	(T/H)XGH motif; other site
443254000761	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
443254000762	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
443254000763	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
443254000764	shikimate binding site; other site
443254000765	NAD(P) binding site [chemical binding]; other site
443254000766	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
443254000767	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
443254000768	putative RNA binding site [nucleotide binding]; other site
443254000769	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254000770	S-adenosylmethionine binding site [chemical binding]; other site
443254000771	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
443254000772	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
443254000773	DRTGG domain; Region: DRTGG; pfam07085
443254000774	CBS domain; Region: CBS; pfam00571
443254000775	DHHA2 domain; Region: DHHA2; pfam02833
443254000776	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
443254000777	periplasmic chaperone; Provisional; Region: PRK10780
443254000778	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
443254000779	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254000780	Walker A/P-loop; other site
443254000781	ATP binding site [chemical binding]; other site
443254000782	Q-loop/lid; other site
443254000783	ABC transporter signature motif; other site
443254000784	Walker B; other site
443254000785	D-loop; other site
443254000786	H-loop/switch region; other site
443254000787	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
443254000788	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
443254000789	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
443254000790	HIGH motif; other site
443254000791	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
443254000792	active site
443254000793	KMSKS motif; other site
443254000794	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
443254000795	Flavoprotein; Region: Flavoprotein; pfam02441
443254000796	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
443254000797	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
443254000798	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
443254000799	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
443254000800	Predicted permeases [General function prediction only]; Region: COG0679
443254000801	CoA binding domain; Region: CoA_binding; cl17356
443254000802	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
443254000803	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
443254000804	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
443254000805	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
443254000806	putative substrate binding site [chemical binding]; other site
443254000807	putative ATP binding site [chemical binding]; other site
443254000808	FOG: CBS domain [General function prediction only]; Region: COG0517
443254000809	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
443254000810	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
443254000811	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
443254000812	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
443254000813	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
443254000814	homodimer interface [polypeptide binding]; other site
443254000815	substrate-cofactor binding pocket; other site
443254000816	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254000817	catalytic residue [active]
443254000818	Protein of unknown function (DUF721); Region: DUF721; cl02324
443254000819	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
443254000820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254000821	ATP binding site [chemical binding]; other site
443254000822	Mg2+ binding site [ion binding]; other site
443254000823	G-X-G motif; other site
443254000824	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
443254000825	anchoring element; other site
443254000826	dimer interface [polypeptide binding]; other site
443254000827	ATP binding site [chemical binding]; other site
443254000828	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
443254000829	active site
443254000830	putative metal-binding site [ion binding]; other site
443254000831	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
443254000832	cell division protein FtsA; Region: ftsA; TIGR01174
443254000833	Cell division protein FtsA; Region: FtsA; cl17206
443254000834	Cell division protein FtsA; Region: FtsA; pfam14450
443254000835	cell division protein FtsZ; Region: ftsZ; TIGR00065
443254000836	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
443254000837	nucleotide binding site [chemical binding]; other site
443254000838	SulA interaction site; other site
443254000839	Type II/IV secretion system protein; Region: T2SE; pfam00437
443254000840	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
443254000841	Walker A motif; other site
443254000842	ATP binding site [chemical binding]; other site
443254000843	Walker B motif; other site
443254000844	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
443254000845	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
443254000846	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
443254000847	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
443254000848	CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895
443254000849	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
443254000850	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
443254000851	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
443254000852	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
443254000853	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
443254000854	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
443254000855	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
443254000856	DDE domain; Region: DDE_Tnp_IS240; pfam13610
443254000857	Integrase core domain; Region: rve; pfam00665
443254000858	Integrase core domain; Region: rve_3; pfam13683
443254000859	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
443254000860	Transposase; Region: HTH_Tnp_1; pfam01527
443254000861	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254000862	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254000863	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254000864	Walker A/P-loop; other site
443254000865	ATP binding site [chemical binding]; other site
443254000866	Q-loop/lid; other site
443254000867	ABC transporter signature motif; other site
443254000868	Walker B; other site
443254000869	D-loop; other site
443254000870	H-loop/switch region; other site
443254000871	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254000872	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254000873	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
443254000874	Walker A/P-loop; other site
443254000875	ATP binding site [chemical binding]; other site
443254000876	Q-loop/lid; other site
443254000877	ABC transporter signature motif; other site
443254000878	Walker B; other site
443254000879	D-loop; other site
443254000880	H-loop/switch region; other site
443254000881	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
443254000882	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
443254000883	catalytic residue [active]
443254000884	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
443254000885	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
443254000886	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
443254000887	catalytic residues [active]
443254000888	catalytic nucleophile [active]
443254000889	Recombinase; Region: Recombinase; pfam07508
443254000890	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
443254000891	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
443254000892	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
443254000893	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
443254000894	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
443254000895	DNA methylase; Region: N6_N4_Mtase; pfam01555
443254000896	Restriction endonuclease; Region: Mrr_cat; pfam04471
443254000897	Predicted transcriptional regulator [Transcription]; Region: COG2932
443254000898	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
443254000899	sequence-specific DNA binding site [nucleotide binding]; other site
443254000900	salt bridge; other site
443254000901	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
443254000902	Catalytic site [active]
443254000903	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
443254000904	non-specific DNA binding site [nucleotide binding]; other site
443254000905	salt bridge; other site
443254000906	sequence-specific DNA binding site [nucleotide binding]; other site
443254000907	AAA domain; Region: AAA_23; pfam13476
443254000908	RecT family; Region: RecT; pfam03837
443254000909	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
443254000910	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524
443254000911	replicative DNA helicase; Region: DnaB; TIGR00665
443254000912	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
443254000913	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
443254000914	Walker A motif; other site
443254000915	ATP binding site [chemical binding]; other site
443254000916	Walker B motif; other site
443254000917	DNA binding loops [nucleotide binding]
443254000918	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
443254000919	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
443254000920	dimer interface [polypeptide binding]; other site
443254000921	ssDNA binding site [nucleotide binding]; other site
443254000922	tetramer (dimer of dimers) interface [polypeptide binding]; other site
443254000923	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
443254000924	trimer interface [polypeptide binding]; other site
443254000925	active site
443254000926	Shugoshin N-terminal coiled-coil region; Region: Shugoshin_N; pfam07558
443254000927	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
443254000928	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
443254000929	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
443254000930	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
443254000931	non-specific DNA binding site [nucleotide binding]; other site
443254000932	salt bridge; other site
443254000933	sequence-specific DNA binding site [nucleotide binding]; other site
443254000934	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
443254000935	Homeodomain-like domain; Region: HTH_23; cl17451
443254000936	Phage terminase large subunit; Region: Terminase_3; cl12054
443254000937	Terminase-like family; Region: Terminase_6; pfam03237
443254000938	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
443254000939	Uncharacterized protein conserved in archaea (DUF2115); Region: DUF2115; cl01681
443254000940	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
443254000941	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
443254000942	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
443254000943	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
443254000944	Interdomain contacts; other site
443254000945	Cytokine receptor motif; other site
443254000946	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
443254000947	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
443254000948	active site
443254000949	metal binding site [ion binding]; metal-binding site
443254000950	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
443254000951	Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890
443254000952	Bacterial sugar transferase; Region: Bac_transf; pfam02397
443254000953	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
443254000954	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254000955	Walker A/P-loop; other site
443254000956	ATP binding site [chemical binding]; other site
443254000957	Q-loop/lid; other site
443254000958	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
443254000959	ABC transporter signature motif; other site
443254000960	Walker B; other site
443254000961	D-loop; other site
443254000962	H-loop/switch region; other site
443254000963	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
443254000964	FAD binding domain; Region: FAD_binding_4; pfam01565
443254000965	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
443254000966	Uncharacterized conserved protein [Function unknown]; Region: COG1434
443254000967	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
443254000968	putative active site [active]
443254000969	ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597
443254000970	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
443254000971	GTP/Mg2+ binding site [chemical binding]; other site
443254000972	G4 box; other site
443254000973	G5 box; other site
443254000974	G1 box; other site
443254000975	Switch I region; other site
443254000976	G2 box; other site
443254000977	G3 box; other site
443254000978	Switch II region; other site
443254000979	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
443254000980	Propanediol utilisation protein PduL; Region: PduL; pfam06130
443254000981	Propanediol utilisation protein PduL; Region: PduL; pfam06130
443254000982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254000983	S-adenosylmethionine binding site [chemical binding]; other site
443254000984	RNA polymerase factor sigma-70; Validated; Region: PRK08295
443254000985	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
443254000986	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
443254000987	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
443254000988	HIGH motif; other site
443254000989	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
443254000990	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
443254000991	active site
443254000992	KMSKS motif; other site
443254000993	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
443254000994	tRNA binding surface [nucleotide binding]; other site
443254000995	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
443254000996	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
443254000997	CoA binding domain; Region: CoA_binding; smart00881
443254000998	Predicted methyltransferases [General function prediction only]; Region: COG0313
443254000999	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
443254001000	putative SAM binding site [chemical binding]; other site
443254001001	putative homodimer interface [polypeptide binding]; other site
443254001002	Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601
443254001003	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
443254001004	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
443254001005	DXD motif; other site
443254001006	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
443254001007	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
443254001008	active site
443254001009	catalytic tetrad [active]
443254001010	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
443254001011	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
443254001012	putative substrate binding site [chemical binding]; other site
443254001013	putative ATP binding site [chemical binding]; other site
443254001014	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
443254001015	active site
443254001016	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
443254001017	active site
443254001018	dimer interface [polypeptide binding]; other site
443254001019	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
443254001020	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
443254001021	heterodimer interface [polypeptide binding]; other site
443254001022	active site
443254001023	FMN binding site [chemical binding]; other site
443254001024	homodimer interface [polypeptide binding]; other site
443254001025	substrate binding site [chemical binding]; other site
443254001026	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
443254001027	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
443254001028	FAD binding pocket [chemical binding]; other site
443254001029	conserved FAD binding motif [chemical binding]; other site
443254001030	phosphate binding motif [ion binding]; other site
443254001031	beta-alpha-beta structure motif; other site
443254001032	NAD binding pocket [chemical binding]; other site
443254001033	dihydroorotase; Validated; Region: pyrC; PRK09357
443254001034	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
443254001035	active site
443254001036	bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376
443254001037	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
443254001038	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
443254001039	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
443254001040	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
443254001041	AIR carboxylase; Region: AIRC; smart01001
443254001042	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
443254001043	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
443254001044	ATP binding site [chemical binding]; other site
443254001045	active site
443254001046	substrate binding site [chemical binding]; other site
443254001047	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
443254001048	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
443254001049	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
443254001050	putative active site [active]
443254001051	catalytic triad [active]
443254001052	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
443254001053	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
443254001054	dimerization interface [polypeptide binding]; other site
443254001055	ATP binding site [chemical binding]; other site
443254001056	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
443254001057	dimerization interface [polypeptide binding]; other site
443254001058	ATP binding site [chemical binding]; other site
443254001059	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
443254001060	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
443254001061	active site
443254001062	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
443254001063	active site
443254001064	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
443254001065	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
443254001066	dimerization interface [polypeptide binding]; other site
443254001067	putative ATP binding site [chemical binding]; other site
443254001068	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
443254001069	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
443254001070	active site
443254001071	substrate binding site [chemical binding]; other site
443254001072	cosubstrate binding site; other site
443254001073	catalytic site [active]
443254001074	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
443254001075	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
443254001076	purine monophosphate binding site [chemical binding]; other site
443254001077	dimer interface [polypeptide binding]; other site
443254001078	putative catalytic residues [active]
443254001079	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
443254001080	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
443254001081	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
443254001082	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
443254001083	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
443254001084	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
443254001085	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
443254001086	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
443254001087	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
443254001088	Na2 binding site [ion binding]; other site
443254001089	putative substrate binding site 1 [chemical binding]; other site
443254001090	Na binding site 1 [ion binding]; other site
443254001091	putative substrate binding site 2 [chemical binding]; other site
443254001092	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
443254001093	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
443254001094	transmembrane helices; other site
443254001095	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
443254001096	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
443254001097	dimer interface [polypeptide binding]; other site
443254001098	phosphorylation site [posttranslational modification]
443254001099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254001100	ATP binding site [chemical binding]; other site
443254001101	Mg2+ binding site [ion binding]; other site
443254001102	G-X-G motif; other site
443254001103	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
443254001104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254001105	active site
443254001106	phosphorylation site [posttranslational modification]
443254001107	intermolecular recognition site; other site
443254001108	dimerization interface [polypeptide binding]; other site
443254001109	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
443254001110	DNA binding site [nucleotide binding]
443254001111	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
443254001112	PhoU domain; Region: PhoU; pfam01895
443254001113	PhoU domain; Region: PhoU; pfam01895
443254001114	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
443254001115	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
443254001116	Walker A/P-loop; other site
443254001117	ATP binding site [chemical binding]; other site
443254001118	Q-loop/lid; other site
443254001119	ABC transporter signature motif; other site
443254001120	Walker B; other site
443254001121	D-loop; other site
443254001122	H-loop/switch region; other site
443254001123	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
443254001124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254001125	dimer interface [polypeptide binding]; other site
443254001126	conserved gate region; other site
443254001127	putative PBP binding loops; other site
443254001128	ABC-ATPase subunit interface; other site
443254001129	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
443254001130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254001131	dimer interface [polypeptide binding]; other site
443254001132	conserved gate region; other site
443254001133	putative PBP binding loops; other site
443254001134	ABC-ATPase subunit interface; other site
443254001135	PBP superfamily domain; Region: PBP_like_2; cl17296
443254001136	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
443254001137	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
443254001138	Domain of unknown function (DUF2828); Region: DUF2828; pfam11443
443254001139	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
443254001140	metal ion-dependent adhesion site (MIDAS); other site
443254001141	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
443254001142	binding surface
443254001143	TPR motif; other site
443254001144	Tetratricopeptide repeat; Region: TPR_12; pfam13424
443254001145	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cd00525
443254001146	nucleotide binding site [chemical binding]; other site
443254001147	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
443254001148	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
443254001149	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
443254001150	active site
443254001151	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
443254001152	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
443254001153	Domain of unknown function (DUF1874); Region: DUF1874; cl07531
443254001154	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
443254001155	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
443254001156	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
443254001157	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
443254001158	CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749
443254001159	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
443254001160	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
443254001161	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
443254001162	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679
443254001163	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
443254001164	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
443254001165	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254001166	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
443254001167	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
443254001168	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
443254001169	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
443254001170	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
443254001171	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
443254001172	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
443254001173	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
443254001174	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254001175	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
443254001176	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
443254001177	ligand binding site [chemical binding]; other site
443254001178	flexible hinge region; other site
443254001179	Transcriptional regulators [Transcription]; Region: PurR; COG1609
443254001180	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
443254001181	DNA binding site [nucleotide binding]
443254001182	domain linker motif; other site
443254001183	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
443254001184	dimerization interface [polypeptide binding]; other site
443254001185	ligand binding site [chemical binding]; other site
443254001186	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
443254001187	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
443254001188	active site
443254001189	metal binding site [ion binding]; metal-binding site
443254001190	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
443254001191	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254001192	dimer interface [polypeptide binding]; other site
443254001193	conserved gate region; other site
443254001194	putative PBP binding loops; other site
443254001195	ABC-ATPase subunit interface; other site
443254001196	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254001197	dimer interface [polypeptide binding]; other site
443254001198	conserved gate region; other site
443254001199	putative PBP binding loops; other site
443254001200	ABC-ATPase subunit interface; other site
443254001201	peptide chain release factor 1; Validated; Region: prfA; PRK00591
443254001202	This domain is found in peptide chain release factors; Region: PCRF; smart00937
443254001203	RF-1 domain; Region: RF-1; pfam00472
443254001204	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
443254001205	homotrimer interaction site [polypeptide binding]; other site
443254001206	putative active site [active]
443254001207	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
443254001208	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
443254001209	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
443254001210	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
443254001211	active site
443254001212	dimer interface [polypeptide binding]; other site
443254001213	motif 1; other site
443254001214	motif 2; other site
443254001215	motif 3; other site
443254001216	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
443254001217	anticodon binding site; other site
443254001218	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
443254001219	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
443254001220	ligand binding site [chemical binding]; other site
443254001221	flexible hinge region; other site
443254001222	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
443254001223	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
443254001224	ligand binding site [chemical binding]; other site
443254001225	flexible hinge region; other site
443254001226	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
443254001227	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254001228	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
443254001229	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254001230	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
443254001231	putative ADP-binding pocket [chemical binding]; other site
443254001232	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
443254001233	AAA domain; Region: AAA_14; pfam13173
443254001234	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
443254001235	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
443254001236	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
443254001237	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
443254001238	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
443254001239	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
443254001240	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
443254001241	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
443254001242	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
443254001243	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
443254001244	dimer interface [polypeptide binding]; other site
443254001245	ssDNA binding site [nucleotide binding]; other site
443254001246	tetramer (dimer of dimers) interface [polypeptide binding]; other site
443254001247	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
443254001248	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
443254001249	active site
443254001250	catalytic site [active]
443254001251	substrate binding site [chemical binding]; other site
443254001252	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
443254001253	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
443254001254	putative active site [active]
443254001255	PhoH-like protein; Region: PhoH; pfam02562
443254001256	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
443254001257	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
443254001258	motif II; other site
443254001259	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
443254001260	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
443254001261	motif II; other site
443254001262	Uncharacterized conserved protein [Function unknown]; Region: COG0432
443254001263	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
443254001264	beta-galactosidase; Region: BGL; TIGR03356
443254001265	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
443254001266	dimerization interface [polypeptide binding]; other site
443254001267	putative DNA binding site [nucleotide binding]; other site
443254001268	putative Zn2+ binding site [ion binding]; other site
443254001269	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
443254001270	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
443254001271	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
443254001272	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
443254001273	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
443254001274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254001275	Walker A/P-loop; other site
443254001276	ATP binding site [chemical binding]; other site
443254001277	Q-loop/lid; other site
443254001278	ABC transporter signature motif; other site
443254001279	Walker B; other site
443254001280	D-loop; other site
443254001281	H-loop/switch region; other site
443254001282	Protein of unknown function DUF45; Region: DUF45; pfam01863
443254001283	alanine-tRNA ligase; Region: PLN02961
443254001284	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
443254001285	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
443254001286	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
443254001287	nucleotide binding site [chemical binding]; other site
443254001288	NEF interaction site [polypeptide binding]; other site
443254001289	SBD interface [polypeptide binding]; other site
443254001290	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
443254001291	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
443254001292	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
443254001293	active site
443254001294	HIGH motif; other site
443254001295	KMSK motif region; other site
443254001296	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
443254001297	tRNA binding surface [nucleotide binding]; other site
443254001298	anticodon binding site; other site
443254001299	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
443254001300	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
443254001301	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254001302	FeS/SAM binding site; other site
443254001303	Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632
443254001304	putative inhibitory loop; other site
443254001305	Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186
443254001306	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
443254001307	putative active site [active]
443254001308	metal binding site [ion binding]; metal-binding site
443254001309	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
443254001310	Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085
443254001311	active site
443254001312	putative catalytic site [active]
443254001313	phosphate binding site A [ion binding]; other site
443254001314	DNA binding site [nucleotide binding]
443254001315	metal binding site A [ion binding]; metal-binding site
443254001316	putative AP binding site [nucleotide binding]; other site
443254001317	putative metal binding site B [ion binding]; other site
443254001318	phosphate binding site B [ion binding]; other site
443254001319	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
443254001320	EamA-like transporter family; Region: EamA; pfam00892
443254001321	EamA-like transporter family; Region: EamA; pfam00892
443254001322	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
443254001323	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
443254001324	GTP-binding protein YchF; Reviewed; Region: PRK09601
443254001325	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
443254001326	G1 box; other site
443254001327	GTP/Mg2+ binding site [chemical binding]; other site
443254001328	Switch I region; other site
443254001329	G3 box; other site
443254001330	Switch II region; other site
443254001331	G4 box; other site
443254001332	G5 box; other site
443254001333	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
443254001334	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
443254001335	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
443254001336	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
443254001337	nucleotide binding site [chemical binding]; other site
443254001338	Coenzyme A transferase; Region: CoA_trans; cl17247
443254001339	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
443254001340	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
443254001341	active site 2 [active]
443254001342	active site 1 [active]
443254001343	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
443254001344	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
443254001345	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
443254001346	NAD(P) binding site [chemical binding]; other site
443254001347	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
443254001348	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254001349	FeS/SAM binding site; other site
443254001350	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
443254001351	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
443254001352	dimer interaction site [polypeptide binding]; other site
443254001353	substrate-binding tunnel; other site
443254001354	active site
443254001355	catalytic site [active]
443254001356	substrate binding site [chemical binding]; other site
443254001357	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254001358	Walker A/P-loop; other site
443254001359	ATP binding site [chemical binding]; other site
443254001360	Q-loop/lid; other site
443254001361	ABC transporter signature motif; other site
443254001362	Walker B; other site
443254001363	D-loop; other site
443254001364	H-loop/switch region; other site
443254001365	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
443254001366	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
443254001367	B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067
443254001368	B12 binding site [chemical binding]; other site
443254001369	cobalt ligand [ion binding]; other site
443254001370	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
443254001371	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
443254001372	NAD(P) binding site [chemical binding]; other site
443254001373	homotetramer interface [polypeptide binding]; other site
443254001374	homodimer interface [polypeptide binding]; other site
443254001375	active site
443254001376	putative acyltransferase; Provisional; Region: PRK05790
443254001377	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
443254001378	dimer interface [polypeptide binding]; other site
443254001379	active site
443254001380	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
443254001381	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
443254001382	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
443254001383	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
443254001384	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
443254001385	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
443254001386	Walker A/P-loop; other site
443254001387	ATP binding site [chemical binding]; other site
443254001388	Q-loop/lid; other site
443254001389	ABC transporter signature motif; other site
443254001390	Walker B; other site
443254001391	D-loop; other site
443254001392	H-loop/switch region; other site
443254001393	Peptidase family S41; Region: Peptidase_S41; pfam03572
443254001394	Active site serine [active]
443254001395	PspC domain; Region: PspC; pfam04024
443254001396	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
443254001397	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
443254001398	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
443254001399	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
443254001400	metal-dependent hydrolase; Provisional; Region: PRK00685
443254001401	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
443254001402	catalytic residues [active]
443254001403	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
443254001404	Protein of unknown function (DUF503); Region: DUF503; pfam04456
443254001405	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
443254001406	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
443254001407	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
443254001408	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
443254001409	FtsX-like permease family; Region: FtsX; pfam02687
443254001410	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
443254001411	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
443254001412	Walker A/P-loop; other site
443254001413	ATP binding site [chemical binding]; other site
443254001414	Q-loop/lid; other site
443254001415	ABC transporter signature motif; other site
443254001416	Walker B; other site
443254001417	D-loop; other site
443254001418	H-loop/switch region; other site
443254001419	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
443254001420	active site
443254001421	multimer interface [polypeptide binding]; other site
443254001422	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
443254001423	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
443254001424	putative RNA binding site [nucleotide binding]; other site
443254001425	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254001426	S-adenosylmethionine binding site [chemical binding]; other site
443254001427	ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448
443254001428	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
443254001429	ligand binding site; other site
443254001430	oligomer interface; other site
443254001431	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
443254001432	dimer interface [polypeptide binding]; other site
443254001433	N-terminal domain interface [polypeptide binding]; other site
443254001434	sulfate 1 binding site; other site
443254001435	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
443254001436	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
443254001437	ligand binding site; other site
443254001438	oligomer interface; other site
443254001439	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
443254001440	dimer interface [polypeptide binding]; other site
443254001441	N-terminal domain interface [polypeptide binding]; other site
443254001442	sulfate 1 binding site; other site
443254001443	Biotin synthase-related enzyme [General function prediction only]; Region: COG2516
443254001444	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254001445	FeS/SAM binding site; other site
443254001446	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
443254001447	SLBB domain; Region: SLBB; pfam10531
443254001448	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
443254001449	FMN-binding domain; Region: FMN_bind; cl01081
443254001450	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
443254001451	electron transport complex RsxE subunit; Provisional; Region: PRK12405
443254001452	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
443254001453	Putative Fe-S cluster; Region: FeS; cl17515
443254001454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
443254001455	putative substrate translocation pore; other site
443254001456	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
443254001457	C-terminal peptidase (prc); Region: prc; TIGR00225
443254001458	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
443254001459	protein binding site [polypeptide binding]; other site
443254001460	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
443254001461	Catalytic dyad [active]
443254001462	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
443254001463	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
443254001464	active site
443254001465	Transcriptional regulator [Transcription]; Region: LysR; COG0583
443254001466	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
443254001467	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
443254001468	dimerization interface [polypeptide binding]; other site
443254001469	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293
443254001470	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
443254001471	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
443254001472	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
443254001473	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
443254001474	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
443254001475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254001476	dimer interface [polypeptide binding]; other site
443254001477	conserved gate region; other site
443254001478	putative PBP binding loops; other site
443254001479	ABC-ATPase subunit interface; other site
443254001480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254001481	dimer interface [polypeptide binding]; other site
443254001482	conserved gate region; other site
443254001483	putative PBP binding loops; other site
443254001484	ABC-ATPase subunit interface; other site
443254001485	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
443254001486	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254001487	Walker A/P-loop; other site
443254001488	ATP binding site [chemical binding]; other site
443254001489	Q-loop/lid; other site
443254001490	ABC transporter signature motif; other site
443254001491	Walker B; other site
443254001492	D-loop; other site
443254001493	H-loop/switch region; other site
443254001494	TOBE domain; Region: TOBE_2; pfam08402
443254001495	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
443254001496	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
443254001497	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
443254001498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254001499	dimer interface [polypeptide binding]; other site
443254001500	conserved gate region; other site
443254001501	putative PBP binding loops; other site
443254001502	ABC-ATPase subunit interface; other site
443254001503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254001504	dimer interface [polypeptide binding]; other site
443254001505	conserved gate region; other site
443254001506	putative PBP binding loops; other site
443254001507	ABC-ATPase subunit interface; other site
443254001508	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
443254001509	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254001510	Walker A/P-loop; other site
443254001511	ATP binding site [chemical binding]; other site
443254001512	Q-loop/lid; other site
443254001513	ABC transporter signature motif; other site
443254001514	Walker B; other site
443254001515	D-loop; other site
443254001516	H-loop/switch region; other site
443254001517	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
443254001518	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
443254001519	RNA binding surface [nucleotide binding]; other site
443254001520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254001521	S-adenosylmethionine binding site [chemical binding]; other site
443254001522	GMP synthase; Reviewed; Region: guaA; PRK00074
443254001523	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
443254001524	AMP/PPi binding site [chemical binding]; other site
443254001525	candidate oxyanion hole; other site
443254001526	catalytic triad [active]
443254001527	potential glutamine specificity residues [chemical binding]; other site
443254001528	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
443254001529	ATP Binding subdomain [chemical binding]; other site
443254001530	Ligand Binding sites [chemical binding]; other site
443254001531	Dimerization subdomain; other site
443254001532	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
443254001533	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
443254001534	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
443254001535	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
443254001536	active site
443254001537	Major Facilitator Superfamily; Region: MFS_1; pfam07690
443254001538	ChaB; Region: ChaB; cl01887
443254001539	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
443254001540	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
443254001541	active site
443254001542	Zn binding site [ion binding]; other site
443254001543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254001544	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
443254001545	Walker A/P-loop; other site
443254001546	ATP binding site [chemical binding]; other site
443254001547	Q-loop/lid; other site
443254001548	ABC transporter signature motif; other site
443254001549	Walker B; other site
443254001550	D-loop; other site
443254001551	H-loop/switch region; other site
443254001552	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
443254001553	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
443254001554	active site
443254001555	Na/Ca binding site [ion binding]; other site
443254001556	catalytic site [active]
443254001557	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
443254001558	Zn binding site [ion binding]; other site
443254001559	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
443254001560	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
443254001561	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
443254001562	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
443254001563	Isochorismatase family; Region: Isochorismatase; pfam00857
443254001564	catalytic triad [active]
443254001565	conserved cis-peptide bond; other site
443254001566	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
443254001567	homodimer interface [polypeptide binding]; other site
443254001568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254001569	catalytic residue [active]
443254001570	Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303
443254001571	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
443254001572	putative ligand binding site [chemical binding]; other site
443254001573	NAD binding site [chemical binding]; other site
443254001574	dimerization interface [polypeptide binding]; other site
443254001575	catalytic site [active]
443254001576	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
443254001577	septum site-determining protein MinD; Region: minD_bact; TIGR01968
443254001578	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
443254001579	Switch I; other site
443254001580	Switch II; other site
443254001581	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
443254001582	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
443254001583	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
443254001584	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254001585	dimerization interface [polypeptide binding]; other site
443254001586	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254001587	dimer interface [polypeptide binding]; other site
443254001588	putative CheW interface [polypeptide binding]; other site
443254001589	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
443254001590	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
443254001591	substrate binding pocket [chemical binding]; other site
443254001592	membrane-bound complex binding site; other site
443254001593	PAS domain S-box; Region: sensory_box; TIGR00229
443254001594	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254001595	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254001596	metal binding site [ion binding]; metal-binding site
443254001597	active site
443254001598	I-site; other site
443254001599	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
443254001600	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
443254001601	ligand binding site [chemical binding]; other site
443254001602	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
443254001603	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
443254001604	putative active site [active]
443254001605	catalytic site [active]
443254001606	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
443254001607	PLD-like domain; Region: PLDc_2; pfam13091
443254001608	putative active site [active]
443254001609	catalytic site [active]
443254001610	Haemolysin-III related; Region: HlyIII; cl03831
443254001611	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
443254001612	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
443254001613	active site
443254001614	dimer interfaces [polypeptide binding]; other site
443254001615	catalytic residues [active]
443254001616	ATP synthase subunit D; Region: ATP-synt_D; pfam01813
443254001617	V-type ATP synthase subunit B; Provisional; Region: PRK04196
443254001618	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
443254001619	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
443254001620	Walker A motif homologous position; other site
443254001621	Walker B motif; other site
443254001622	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
443254001623	V-type ATP synthase subunit A; Provisional; Region: PRK04192
443254001624	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
443254001625	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
443254001626	Walker A motif/ATP binding site; other site
443254001627	Walker B motif; other site
443254001628	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
443254001629	V-type ATP synthase subunit E; Provisional; Region: PRK02292
443254001630	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990
443254001631	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
443254001632	V-type ATP synthase subunit I; Validated; Region: PRK05771
443254001633	ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992
443254001634	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
443254001635	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
443254001636	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
443254001637	active site
443254001638	metal binding site [ion binding]; metal-binding site
443254001639	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254001640	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254001641	metal binding site [ion binding]; metal-binding site
443254001642	active site
443254001643	I-site; other site
443254001644	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
443254001645	active site
443254001646	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254001647	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254001648	metal binding site [ion binding]; metal-binding site
443254001649	active site
443254001650	I-site; other site
443254001651	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
443254001652	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
443254001653	metal-binding site [ion binding]
443254001654	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
443254001655	Soluble P-type ATPase [General function prediction only]; Region: COG4087
443254001656	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
443254001657	dimerization interface [polypeptide binding]; other site
443254001658	putative DNA binding site [nucleotide binding]; other site
443254001659	putative Zn2+ binding site [ion binding]; other site
443254001660	Protein of unknown function (DUF996); Region: DUF996; cl00970
443254001661	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
443254001662	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
443254001663	active site
443254001664	substrate binding site [chemical binding]; other site
443254001665	metal binding site [ion binding]; metal-binding site
443254001666	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
443254001667	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
443254001668	metal binding site [ion binding]; metal-binding site
443254001669	dimer interface [polypeptide binding]; other site
443254001670	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
443254001671	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
443254001672	inhibitor-cofactor binding pocket; inhibition site
443254001673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254001674	catalytic residue [active]
443254001675	aspartate kinase; Reviewed; Region: PRK06635
443254001676	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
443254001677	putative nucleotide binding site [chemical binding]; other site
443254001678	putative catalytic residues [active]
443254001679	putative Mg ion binding site [ion binding]; other site
443254001680	putative aspartate binding site [chemical binding]; other site
443254001681	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
443254001682	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
443254001683	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
443254001684	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
443254001685	trimer interface [polypeptide binding]; other site
443254001686	active site
443254001687	substrate binding site [chemical binding]; other site
443254001688	CoA binding site [chemical binding]; other site
443254001689	dihydrodipicolinate reductase; Provisional; Region: PRK00048
443254001690	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
443254001691	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
443254001692	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
443254001693	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
443254001694	dimer interface [polypeptide binding]; other site
443254001695	active site
443254001696	catalytic residue [active]
443254001697	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
443254001698	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
443254001699	active site
443254001700	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
443254001701	substrate binding site [chemical binding]; other site
443254001702	catalytic residues [active]
443254001703	dimer interface [polypeptide binding]; other site
443254001704	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
443254001705	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
443254001706	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254001707	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254001708	metal binding site [ion binding]; metal-binding site
443254001709	active site
443254001710	I-site; other site
443254001711	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
443254001712	Uncharacterized conserved protein [Function unknown]; Region: COG2006
443254001713	4Fe-4S binding domain; Region: Fer4_6; pfam12837
443254001714	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
443254001715	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
443254001716	substrate binding site [chemical binding]; other site
443254001717	ATP binding site [chemical binding]; other site
443254001718	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254001719	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254001720	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
443254001721	Walker A/P-loop; other site
443254001722	ATP binding site [chemical binding]; other site
443254001723	Q-loop/lid; other site
443254001724	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254001725	ABC transporter signature motif; other site
443254001726	Walker B; other site
443254001727	D-loop; other site
443254001728	H-loop/switch region; other site
443254001729	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
443254001730	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254001731	Walker A/P-loop; other site
443254001732	ATP binding site [chemical binding]; other site
443254001733	Q-loop/lid; other site
443254001734	ABC transporter signature motif; other site
443254001735	Walker B; other site
443254001736	D-loop; other site
443254001737	H-loop/switch region; other site
443254001738	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
443254001739	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
443254001740	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
443254001741	motif II; other site
443254001742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254001743	S-adenosylmethionine binding site [chemical binding]; other site
443254001744	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
443254001745	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
443254001746	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
443254001747	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
443254001748	Protein of unknown function (DUF3919); Region: DUF3919; pfam13057
443254001749	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
443254001750	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254001751	dimerization interface [polypeptide binding]; other site
443254001752	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
443254001753	dimer interface [polypeptide binding]; other site
443254001754	phosphorylation site [posttranslational modification]
443254001755	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254001756	ATP binding site [chemical binding]; other site
443254001757	Mg2+ binding site [ion binding]; other site
443254001758	G-X-G motif; other site
443254001759	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
443254001760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254001761	active site
443254001762	phosphorylation site [posttranslational modification]
443254001763	intermolecular recognition site; other site
443254001764	dimerization interface [polypeptide binding]; other site
443254001765	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
443254001766	DNA binding site [nucleotide binding]
443254001767	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254001768	Zn2+ binding site [ion binding]; other site
443254001769	Mg2+ binding site [ion binding]; other site
443254001770	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
443254001771	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
443254001772	Ligand Binding Site [chemical binding]; other site
443254001773	FtsH Extracellular; Region: FtsH_ext; pfam06480
443254001774	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
443254001775	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254001776	Walker A motif; other site
443254001777	ATP binding site [chemical binding]; other site
443254001778	Walker B motif; other site
443254001779	arginine finger; other site
443254001780	Peptidase family M41; Region: Peptidase_M41; pfam01434
443254001781	Predicted thioesterase [General function prediction only]; Region: COG5496
443254001782	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
443254001783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254001784	active site
443254001785	phosphorylation site [posttranslational modification]
443254001786	intermolecular recognition site; other site
443254001787	dimerization interface [polypeptide binding]; other site
443254001788	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
443254001789	DNA binding site [nucleotide binding]
443254001790	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
443254001791	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
443254001792	dimer interface [polypeptide binding]; other site
443254001793	phosphorylation site [posttranslational modification]
443254001794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254001795	ATP binding site [chemical binding]; other site
443254001796	Mg2+ binding site [ion binding]; other site
443254001797	G-X-G motif; other site
443254001798	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
443254001799	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
443254001800	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
443254001801	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
443254001802	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
443254001803	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
443254001804	elongation factor G; Reviewed; Region: PRK12740
443254001805	G1 box; other site
443254001806	putative GEF interaction site [polypeptide binding]; other site
443254001807	GTP/Mg2+ binding site [chemical binding]; other site
443254001808	Switch I region; other site
443254001809	G2 box; other site
443254001810	G3 box; other site
443254001811	Switch II region; other site
443254001812	G4 box; other site
443254001813	G5 box; other site
443254001814	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
443254001815	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
443254001816	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
443254001817	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
443254001818	dimerization interface [polypeptide binding]; other site
443254001819	putative DNA binding site [nucleotide binding]; other site
443254001820	putative Zn2+ binding site [ion binding]; other site
443254001821	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
443254001822	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
443254001823	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
443254001824	hypothetical protein; Provisional; Region: PRK08378
443254001825	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
443254001826	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
443254001827	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
443254001828	NADH dehydrogenase subunit M; Validated; Region: PRK08668
443254001829	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
443254001830	NADH dehydrogenase; Region: NADHdh; cl00469
443254001831	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
443254001832	NADH dehydrogenase subunit B; Validated; Region: PRK06411
443254001833	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
443254001834	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
443254001835	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
443254001836	NADH dehydrogenase subunit D; Validated; Region: PRK06075
443254001837	putative oxidoreductase; Provisional; Region: PRK13984
443254001838	4Fe-4S binding domain; Region: Fer4; pfam00037
443254001839	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
443254001840	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
443254001841	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
443254001842	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
443254001843	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
443254001844	putative substrate binding site [chemical binding]; other site
443254001845	putative ATP binding site [chemical binding]; other site
443254001846	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
443254001847	Thiamine pyrophosphokinase; Region: TPK; cd07995
443254001848	active site
443254001849	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
443254001850	dimerization interface [polypeptide binding]; other site
443254001851	thiamine binding site [chemical binding]; other site
443254001852	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
443254001853	MarR family; Region: MarR; pfam01047
443254001854	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
443254001855	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
443254001856	NAD(P) binding site [chemical binding]; other site
443254001857	active site
443254001858	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254001859	dimer interface [polypeptide binding]; other site
443254001860	putative CheW interface [polypeptide binding]; other site
443254001861	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
443254001862	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
443254001863	Uncharacterized conserved protein [Function unknown]; Region: COG5276
443254001864	LVIVD repeat; Region: LVIVD; pfam08309
443254001865	LVIVD repeat; Region: LVIVD; pfam08309
443254001866	LVIVD repeat; Region: LVIVD; pfam08309
443254001867	Uncharacterized conserved protein [Function unknown]; Region: COG5276
443254001868	LVIVD repeat; Region: LVIVD; pfam08309
443254001869	Chromate transporter; Region: Chromate_transp; pfam02417
443254001870	Chromate transporter; Region: Chromate_transp; pfam02417
443254001871	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
443254001872	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
443254001873	Uncharacterized conserved protein [Function unknown]; Region: COG3379
443254001874	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
443254001875	benzoate transport; Region: 2A0115; TIGR00895
443254001876	LVIVD repeat; Region: LVIVD; pfam08309
443254001877	LVIVD repeat; Region: LVIVD; pfam08309
443254001878	LVIVD repeat; Region: LVIVD; pfam08309
443254001879	LVIVD repeat; Region: LVIVD; pfam08309
443254001880	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
443254001881	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
443254001882	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
443254001883	DNA binding residues [nucleotide binding]
443254001884	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
443254001885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
443254001886	Major Facilitator Superfamily; Region: MFS_1; pfam07690
443254001887	putative substrate translocation pore; other site
443254001888	excinuclease ABC subunit B; Provisional; Region: PRK05298
443254001889	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
443254001890	ATP binding site [chemical binding]; other site
443254001891	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
443254001892	nucleotide binding region [chemical binding]; other site
443254001893	ATP-binding site [chemical binding]; other site
443254001894	Ultra-violet resistance protein B; Region: UvrB; pfam12344
443254001895	UvrB/uvrC motif; Region: UVR; pfam02151
443254001896	Fibronectin type 3 domain; Region: FN3; smart00060
443254001897	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
443254001898	active site
443254001899	FOG: WD40-like repeat [Function unknown]; Region: COG1520
443254001900	6-phosphofructokinase; Provisional; Region: PRK14072
443254001901	active site
443254001902	ADP/pyrophosphate binding site [chemical binding]; other site
443254001903	fructose-1,6-bisphosphate binding site; other site
443254001904	dimerization interface [polypeptide binding]; other site
443254001905	allosteric effector site; other site
443254001906	Phosphate transporter family; Region: PHO4; pfam01384
443254001907	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
443254001908	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
443254001909	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
443254001910	HSP70 interaction site [polypeptide binding]; other site
443254001911	CAAX protease self-immunity; Region: Abi; pfam02517
443254001912	CTP synthetase; Validated; Region: pyrG; PRK05380
443254001913	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
443254001914	Catalytic site [active]
443254001915	active site
443254001916	UTP binding site [chemical binding]; other site
443254001917	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
443254001918	active site
443254001919	putative oxyanion hole; other site
443254001920	catalytic triad [active]
443254001921	acyl carrier protein; Provisional; Region: acpP; PRK00982
443254001922	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
443254001923	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
443254001924	dimer interface [polypeptide binding]; other site
443254001925	motif 1; other site
443254001926	active site
443254001927	motif 2; other site
443254001928	motif 3; other site
443254001929	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
443254001930	anticodon binding site; other site
443254001931	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
443254001932	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
443254001933	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
443254001934	TrkA-N domain; Region: TrkA_N; pfam02254
443254001935	TrkA-C domain; Region: TrkA_C; pfam02080
443254001936	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
443254001937	TrkA-N domain; Region: TrkA_N; pfam02254
443254001938	Response regulator receiver domain; Region: Response_reg; pfam00072
443254001939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254001940	active site
443254001941	phosphorylation site [posttranslational modification]
443254001942	intermolecular recognition site; other site
443254001943	dimerization interface [polypeptide binding]; other site
443254001944	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
443254001945	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254001946	Walker A motif; other site
443254001947	ATP binding site [chemical binding]; other site
443254001948	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
443254001949	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
443254001950	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
443254001951	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
443254001952	TPR repeat; Region: TPR_11; pfam13414
443254001953	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
443254001954	binding surface
443254001955	TPR motif; other site
443254001956	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
443254001957	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
443254001958	GTP-binding protein Der; Reviewed; Region: PRK00093
443254001959	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
443254001960	G1 box; other site
443254001961	GTP/Mg2+ binding site [chemical binding]; other site
443254001962	Switch I region; other site
443254001963	G2 box; other site
443254001964	Switch II region; other site
443254001965	G3 box; other site
443254001966	G4 box; other site
443254001967	G5 box; other site
443254001968	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
443254001969	G1 box; other site
443254001970	GTP/Mg2+ binding site [chemical binding]; other site
443254001971	Switch I region; other site
443254001972	G2 box; other site
443254001973	G3 box; other site
443254001974	Switch II region; other site
443254001975	G4 box; other site
443254001976	G5 box; other site
443254001977	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
443254001978	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
443254001979	RNA binding site [nucleotide binding]; other site
443254001980	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
443254001981	RNA binding site [nucleotide binding]; other site
443254001982	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
443254001983	RNA binding site [nucleotide binding]; other site
443254001984	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
443254001985	RNA binding site [nucleotide binding]; other site
443254001986	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
443254001987	RNA binding site [nucleotide binding]; other site
443254001988	LytB protein; Region: LYTB; cl00507
443254001989	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
443254001990	cytidylate kinase; Provisional; Region: cmk; PRK00023
443254001991	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
443254001992	CMP-binding site; other site
443254001993	The sites determining sugar specificity; other site
443254001994	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
443254001995	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
443254001996	dimer interface [polypeptide binding]; other site
443254001997	anticodon binding site; other site
443254001998	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
443254001999	homodimer interface [polypeptide binding]; other site
443254002000	motif 1; other site
443254002001	active site
443254002002	motif 2; other site
443254002003	GAD domain; Region: GAD; pfam02938
443254002004	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
443254002005	active site
443254002006	motif 3; other site
443254002007	S-layer homology domain; Region: SLH; pfam00395
443254002008	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254002009	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254002010	Zn2+ binding site [ion binding]; other site
443254002011	Mg2+ binding site [ion binding]; other site
443254002012	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
443254002013	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
443254002014	Ca binding site [ion binding]; other site
443254002015	active site
443254002016	catalytic site [active]
443254002017	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
443254002018	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
443254002019	N-acetyl-D-glucosamine binding site [chemical binding]; other site
443254002020	catalytic residue [active]
443254002021	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
443254002022	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
443254002023	MOFRL family; Region: MOFRL; pfam05161
443254002024	glycogen branching enzyme; Provisional; Region: PRK05402
443254002025	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
443254002026	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
443254002027	active site
443254002028	catalytic site [active]
443254002029	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
443254002030	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
443254002031	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
443254002032	substrate binding site [chemical binding]; other site
443254002033	dimer interface [polypeptide binding]; other site
443254002034	ATP binding site [chemical binding]; other site
443254002035	ornithine carbamoyltransferase; Validated; Region: PRK02102
443254002036	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
443254002037	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
443254002038	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
443254002039	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
443254002040	putative substrate binding site [chemical binding]; other site
443254002041	nucleotide binding site [chemical binding]; other site
443254002042	nucleotide binding site [chemical binding]; other site
443254002043	homodimer interface [polypeptide binding]; other site
443254002044	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
443254002045	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
443254002046	active site
443254002047	metal binding site [ion binding]; metal-binding site
443254002048	flavoprotein, HI0933 family; Region: TIGR00275
443254002049	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
443254002050	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
443254002051	intersubunit interface [polypeptide binding]; other site
443254002052	AAA domain; Region: AAA_11; pfam13086
443254002053	AAA domain; Region: AAA_30; pfam13604
443254002054	Family description; Region: UvrD_C_2; pfam13538
443254002055	Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277
443254002056	RNA/DNA hybrid binding site [nucleotide binding]; other site
443254002057	active site
443254002058	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
443254002059	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
443254002060	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
443254002061	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
443254002062	4Fe-4S binding domain; Region: Fer4_5; pfam12801
443254002063	4Fe-4S binding domain; Region: Fer4; pfam00037
443254002064	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
443254002065	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
443254002066	Response regulator receiver domain; Region: Response_reg; pfam00072
443254002067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254002068	active site
443254002069	phosphorylation site [posttranslational modification]
443254002070	intermolecular recognition site; other site
443254002071	dimerization interface [polypeptide binding]; other site
443254002072	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254002073	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254002074	metal binding site [ion binding]; metal-binding site
443254002075	active site
443254002076	I-site; other site
443254002077	N-glycosylase/DNA lyase; Provisional; Region: PRK01229
443254002078	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
443254002079	minor groove reading motif; other site
443254002080	helix-hairpin-helix signature motif; other site
443254002081	substrate binding pocket [chemical binding]; other site
443254002082	active site
443254002083	Protein of unknown function (DUF554); Region: DUF554; pfam04474
443254002084	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
443254002085	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
443254002086	Radical SAM superfamily; Region: Radical_SAM; pfam04055
443254002087	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254002088	FeS/SAM binding site; other site
443254002089	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
443254002090	Class III ribonucleotide reductase; Region: RNR_III; cd01675
443254002091	effector binding site; other site
443254002092	active site
443254002093	Zn binding site [ion binding]; other site
443254002094	glycine loop; other site
443254002095	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
443254002096	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
443254002097	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
443254002098	active site
443254002099	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
443254002100	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
443254002101	TM-ABC transporter signature motif; other site
443254002102	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
443254002103	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
443254002104	TM-ABC transporter signature motif; other site
443254002105	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
443254002106	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
443254002107	Walker A/P-loop; other site
443254002108	ATP binding site [chemical binding]; other site
443254002109	Q-loop/lid; other site
443254002110	ABC transporter signature motif; other site
443254002111	Walker B; other site
443254002112	D-loop; other site
443254002113	H-loop/switch region; other site
443254002114	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
443254002115	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
443254002116	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
443254002117	ligand binding site [chemical binding]; other site
443254002118	Survival protein SurE; Region: SurE; cl00448
443254002119	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
443254002120	active site
443254002121	catalytic residues [active]
443254002122	metal binding site [ion binding]; metal-binding site
443254002123	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
443254002124	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
443254002125	putative active site [active]
443254002126	substrate binding site [chemical binding]; other site
443254002127	putative cosubstrate binding site; other site
443254002128	catalytic site [active]
443254002129	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
443254002130	substrate binding site [chemical binding]; other site
443254002131	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
443254002132	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
443254002133	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
443254002134	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254002135	Walker A/P-loop; other site
443254002136	ATP binding site [chemical binding]; other site
443254002137	Q-loop/lid; other site
443254002138	ABC transporter signature motif; other site
443254002139	Walker B; other site
443254002140	D-loop; other site
443254002141	H-loop/switch region; other site
443254002142	Predicted dehydrogenase [General function prediction only]; Region: COG0579
443254002143	hydroxyglutarate oxidase; Provisional; Region: PRK11728
443254002144	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
443254002145	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
443254002146	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
443254002147	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
443254002148	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
443254002149	active site
443254002150	catalytic site [active]
443254002151	competence damage-inducible protein A; Provisional; Region: PRK00549
443254002152	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
443254002153	putative MPT binding site; other site
443254002154	Competence-damaged protein; Region: CinA; pfam02464
443254002155	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
443254002156	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
443254002157	putative binding surface; other site
443254002158	active site
443254002159	P2 response regulator binding domain; Region: P2; pfam07194
443254002160	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
443254002161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254002162	ATP binding site [chemical binding]; other site
443254002163	Mg2+ binding site [ion binding]; other site
443254002164	G-X-G motif; other site
443254002165	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
443254002166	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
443254002167	Response regulator receiver domain; Region: Response_reg; pfam00072
443254002168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254002169	active site
443254002170	phosphorylation site [posttranslational modification]
443254002171	intermolecular recognition site; other site
443254002172	dimerization interface [polypeptide binding]; other site
443254002173	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
443254002174	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
443254002175	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
443254002176	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
443254002177	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
443254002178	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
443254002179	FHIPEP family; Region: FHIPEP; pfam00771
443254002180	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
443254002181	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
443254002182	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
443254002183	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
443254002184	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
443254002185	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
443254002186	CheC-like family; Region: CheC; pfam04509
443254002187	CheC-like family; Region: CheC; pfam04509
443254002188	CheD chemotactic sensory transduction; Region: CheD; cl00810
443254002189	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
443254002190	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
443254002191	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
443254002192	DNA binding residues [nucleotide binding]
443254002193	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
443254002194	DEAD-like helicases superfamily; Region: DEXDc; smart00487
443254002195	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
443254002196	ATP binding site [chemical binding]; other site
443254002197	putative Mg++ binding site [ion binding]; other site
443254002198	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
443254002199	nucleotide binding region [chemical binding]; other site
443254002200	ATP-binding site [chemical binding]; other site
443254002201	TRCF domain; Region: TRCF; pfam03461
443254002202	Staphylococcal nuclease homologues; Region: SNc; smart00318
443254002203	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
443254002204	Catalytic site; other site
443254002205	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
443254002206	dimer interface [polypeptide binding]; other site
443254002207	ADP-ribose binding site [chemical binding]; other site
443254002208	active site
443254002209	nudix motif; other site
443254002210	metal binding site [ion binding]; metal-binding site
443254002211	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
443254002212	active site
443254002213	nucleotide-binding site [chemical binding]; other site
443254002214	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
443254002215	tetramerization interface [polypeptide binding]; other site
443254002216	active site
443254002217	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
443254002218	hypothetical protein; Provisional; Region: PRK13670
443254002219	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
443254002220	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
443254002221	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
443254002222	active site
443254002223	homodimer interface [polypeptide binding]; other site
443254002224	catalytic site [active]
443254002225	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
443254002226	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
443254002227	ATP binding site [chemical binding]; other site
443254002228	putative Mg++ binding site [ion binding]; other site
443254002229	helicase superfamily c-terminal domain; Region: HELICc; smart00490
443254002230	ATP-binding site [chemical binding]; other site
443254002231	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
443254002232	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
443254002233	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254002234	dimerization interface [polypeptide binding]; other site
443254002235	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254002236	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254002237	dimer interface [polypeptide binding]; other site
443254002238	putative CheW interface [polypeptide binding]; other site
443254002239	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
443254002240	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
443254002241	Yqey-like protein; Region: YqeY; pfam09424
443254002242	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
443254002243	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
443254002244	WHG domain; Region: WHG; pfam13305
443254002245	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
443254002246	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
443254002247	FMN binding site [chemical binding]; other site
443254002248	substrate binding site [chemical binding]; other site
443254002249	putative catalytic residue [active]
443254002250	acyl carrier protein; Provisional; Region: acpP; PRK00982
443254002251	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
443254002252	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
443254002253	Walker A/P-loop; other site
443254002254	ATP binding site [chemical binding]; other site
443254002255	Q-loop/lid; other site
443254002256	ABC transporter signature motif; other site
443254002257	Walker B; other site
443254002258	D-loop; other site
443254002259	H-loop/switch region; other site
443254002260	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
443254002261	anti sigma factor interaction site; other site
443254002262	regulatory phosphorylation site [posttranslational modification]; other site
443254002263	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14330
443254002264	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
443254002265	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254002266	FeS/SAM binding site; other site
443254002267	TRAM domain; Region: TRAM; pfam01938
443254002268	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
443254002269	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
443254002270	dimer interface [polypeptide binding]; other site
443254002271	active site
443254002272	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
443254002273	catalytic residues [active]
443254002274	substrate binding site [chemical binding]; other site
443254002275	16S rRNA methyltransferase B; Provisional; Region: PRK14903
443254002276	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
443254002277	putative RNA binding site [nucleotide binding]; other site
443254002278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254002279	S-adenosylmethionine binding site [chemical binding]; other site
443254002280	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
443254002281	active site
443254002282	homotetramer interface [polypeptide binding]; other site
443254002283	homodimer interface [polypeptide binding]; other site
443254002284	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
443254002285	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
443254002286	Tetratricopeptide repeat; Region: TPR_16; pfam13432
443254002287	TPR motif; other site
443254002288	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
443254002289	Glycoprotease family; Region: Peptidase_M22; pfam00814
443254002290	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
443254002291	Interdomain contacts; other site
443254002292	Cytokine receptor motif; other site
443254002293	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
443254002294	Interdomain contacts; other site
443254002295	Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606
443254002296	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
443254002297	active site
443254002298	S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100...; Region: S-100; cl08302
443254002299	Ca2+ binding site [ion binding]; other site
443254002300	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
443254002301	Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335
443254002302	homodimer interface [polypeptide binding]; other site
443254002303	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
443254002304	active site
443254002305	catalytic site [active]
443254002306	maltose binding site 2 [chemical binding]; other site
443254002307	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
443254002308	signal recognition particle protein; Provisional; Region: PRK10867
443254002309	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
443254002310	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
443254002311	P loop; other site
443254002312	GTP binding site [chemical binding]; other site
443254002313	Signal peptide binding domain; Region: SRP_SPB; pfam02978
443254002314	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14524
443254002315	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
443254002316	KH domain; Region: KH_4; pfam13083
443254002317	G-X-X-G motif; other site
443254002318	RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806
443254002319	RimM N-terminal domain; Region: RimM; pfam01782
443254002320	PRC-barrel domain; Region: PRC; pfam05239
443254002321	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
443254002322	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
443254002323	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
443254002324	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
443254002325	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
443254002326	Catalytic site [active]
443254002327	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
443254002328	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
443254002329	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
443254002330	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
443254002331	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254002332	dimerization interface [polypeptide binding]; other site
443254002333	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254002334	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254002335	dimer interface [polypeptide binding]; other site
443254002336	putative CheW interface [polypeptide binding]; other site
443254002337	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
443254002338	transmembrane helices; other site
443254002339	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
443254002340	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
443254002341	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
443254002342	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
443254002343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254002344	dimer interface [polypeptide binding]; other site
443254002345	conserved gate region; other site
443254002346	putative PBP binding loops; other site
443254002347	ABC-ATPase subunit interface; other site
443254002348	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
443254002349	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254002350	dimer interface [polypeptide binding]; other site
443254002351	conserved gate region; other site
443254002352	putative PBP binding loops; other site
443254002353	ABC-ATPase subunit interface; other site
443254002354	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254002355	Zn2+ binding site [ion binding]; other site
443254002356	Mg2+ binding site [ion binding]; other site
443254002357	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
443254002358	active site
443254002359	dimerization interface [polypeptide binding]; other site
443254002360	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
443254002361	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
443254002362	substrate binding site [chemical binding]; other site
443254002363	hexamer interface [polypeptide binding]; other site
443254002364	metal binding site [ion binding]; metal-binding site
443254002365	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
443254002366	RNA binding site [nucleotide binding]; other site
443254002367	homodimer interface [polypeptide binding]; other site
443254002368	GTPase RsgA; Reviewed; Region: PRK00098
443254002369	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
443254002370	GTPase/Zn-binding domain interface [polypeptide binding]; other site
443254002371	GTP/Mg2+ binding site [chemical binding]; other site
443254002372	G4 box; other site
443254002373	G5 box; other site
443254002374	G1 box; other site
443254002375	Switch I region; other site
443254002376	G2 box; other site
443254002377	G3 box; other site
443254002378	Switch II region; other site
443254002379	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
443254002380	PASTA domain; Region: PASTA; pfam03793
443254002381	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14469
443254002382	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254002383	FeS/SAM binding site; other site
443254002384	Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856
443254002385	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
443254002386	FeS/SAM binding site; other site
443254002387	ribonuclease III; Reviewed; Region: rnc; PRK00102
443254002388	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
443254002389	dimerization interface [polypeptide binding]; other site
443254002390	active site
443254002391	metal binding site [ion binding]; metal-binding site
443254002392	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
443254002393	dsRNA binding site [nucleotide binding]; other site
443254002394	transketolase; Reviewed; Region: PRK05899
443254002395	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
443254002396	TPP-binding site [chemical binding]; other site
443254002397	dimer interface [polypeptide binding]; other site
443254002398	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
443254002399	PYR/PP interface [polypeptide binding]; other site
443254002400	dimer interface [polypeptide binding]; other site
443254002401	TPP binding site [chemical binding]; other site
443254002402	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
443254002403	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
443254002404	PSP1 C-terminal conserved region; Region: PSP1; cl00770
443254002405	DNA polymerase III subunit delta'; Validated; Region: PRK08485
443254002406	Protein of unknown function (DUF327); Region: DUF327; pfam03885
443254002407	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
443254002408	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
443254002409	G-X-X-G motif; other site
443254002410	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
443254002411	RxxxH motif; other site
443254002412	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
443254002413	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
443254002414	Uncharacterized conserved protein [Function unknown]; Region: COG0759
443254002415	Ribonuclease P; Region: Ribonuclease_P; pfam00825
443254002416	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
443254002417	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254002418	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254002419	Zn2+ binding site [ion binding]; other site
443254002420	Mg2+ binding site [ion binding]; other site
443254002421	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
443254002422	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
443254002423	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
443254002424	Uncharacterized conserved protein [Function unknown]; Region: COG0327
443254002425	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
443254002426	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
443254002427	Walker A/P-loop; other site
443254002428	ATP binding site [chemical binding]; other site
443254002429	Q-loop/lid; other site
443254002430	ABC transporter signature motif; other site
443254002431	Walker B; other site
443254002432	D-loop; other site
443254002433	H-loop/switch region; other site
443254002434	TOBE domain; Region: TOBE_2; pfam08402
443254002435	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
443254002436	PQQ-like domain; Region: PQQ_2; pfam13360
443254002437	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
443254002438	Trp docking motif [polypeptide binding]; other site
443254002439	PQQ-like domain; Region: PQQ_2; pfam13360
443254002440	active site
443254002441	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
443254002442	Interdomain contacts; other site
443254002443	Cytokine receptor motif; other site
443254002444	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
443254002445	Trp docking motif [polypeptide binding]; other site
443254002446	FOG: WD40-like repeat [Function unknown]; Region: COG1520
443254002447	active site
443254002448	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
443254002449	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
443254002450	Dimer interface [polypeptide binding]; other site
443254002451	anticodon binding site; other site
443254002452	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
443254002453	homodimer interface [polypeptide binding]; other site
443254002454	motif 1; other site
443254002455	motif 2; other site
443254002456	active site
443254002457	motif 3; other site
443254002458	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
443254002459	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254002460	Zn2+ binding site [ion binding]; other site
443254002461	Mg2+ binding site [ion binding]; other site
443254002462	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
443254002463	dimerization interface [polypeptide binding]; other site
443254002464	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254002465	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254002466	dimer interface [polypeptide binding]; other site
443254002467	putative CheW interface [polypeptide binding]; other site
443254002468	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
443254002469	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
443254002470	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
443254002471	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254002472	dimer interface [polypeptide binding]; other site
443254002473	conserved gate region; other site
443254002474	putative PBP binding loops; other site
443254002475	ABC-ATPase subunit interface; other site
443254002476	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
443254002477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254002478	dimer interface [polypeptide binding]; other site
443254002479	conserved gate region; other site
443254002480	putative PBP binding loops; other site
443254002481	ABC-ATPase subunit interface; other site
443254002482	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
443254002483	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
443254002484	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
443254002485	putative active site [active]
443254002486	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
443254002487	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
443254002488	active site
443254002489	homodimer interface [polypeptide binding]; other site
443254002490	catalytic site [active]
443254002491	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
443254002492	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
443254002493	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
443254002494	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
443254002495	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
443254002496	ligand binding site [chemical binding]; other site
443254002497	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254002498	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
443254002499	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254002500	Walker A/P-loop; other site
443254002501	ATP binding site [chemical binding]; other site
443254002502	Q-loop/lid; other site
443254002503	ABC transporter signature motif; other site
443254002504	Walker B; other site
443254002505	D-loop; other site
443254002506	H-loop/switch region; other site
443254002507	pyruvate phosphate dikinase; Provisional; Region: PRK09279
443254002508	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
443254002509	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
443254002510	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
443254002511	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
443254002512	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
443254002513	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
443254002514	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
443254002515	metal binding site [ion binding]; metal-binding site
443254002516	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
443254002517	Protein of unknown function (DUF3834); Region: DUF3834; pfam12916
443254002518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
443254002519	putative substrate translocation pore; other site
443254002520	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
443254002521	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
443254002522	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
443254002523	alphaNTD - beta interaction site [polypeptide binding]; other site
443254002524	alphaNTD homodimer interface [polypeptide binding]; other site
443254002525	alphaNTD - beta' interaction site [polypeptide binding]; other site
443254002526	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
443254002527	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
443254002528	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
443254002529	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
443254002530	RNA binding surface [nucleotide binding]; other site
443254002531	30S ribosomal protein S11; Validated; Region: PRK05309
443254002532	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
443254002533	30S ribosomal protein S13; Region: bact_S13; TIGR03631
443254002534	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
443254002535	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
443254002536	rRNA binding site [nucleotide binding]; other site
443254002537	predicted 30S ribosome binding site; other site
443254002538	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
443254002539	active site
443254002540	adenylate kinase; Reviewed; Region: adk; PRK00279
443254002541	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
443254002542	AMP-binding site [chemical binding]; other site
443254002543	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
443254002544	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
443254002545	SecY translocase; Region: SecY; pfam00344
443254002546	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
443254002547	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
443254002548	23S rRNA binding site [nucleotide binding]; other site
443254002549	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
443254002550	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
443254002551	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
443254002552	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
443254002553	5S rRNA interface [nucleotide binding]; other site
443254002554	L27 interface [polypeptide binding]; other site
443254002555	23S rRNA interface [nucleotide binding]; other site
443254002556	L5 interface [polypeptide binding]; other site
443254002557	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
443254002558	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
443254002559	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
443254002560	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
443254002561	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
443254002562	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
443254002563	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
443254002564	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
443254002565	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
443254002566	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
443254002567	RNA binding site [nucleotide binding]; other site
443254002568	Protein of unknown function (DUF2614); Region: DUF2614; cl07936
443254002569	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
443254002570	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
443254002571	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
443254002572	L23 interface [polypeptide binding]; other site
443254002573	trigger factor interaction site; other site
443254002574	23S rRNA interface [nucleotide binding]; other site
443254002575	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
443254002576	23S rRNA interface [nucleotide binding]; other site
443254002577	5S rRNA interface [nucleotide binding]; other site
443254002578	putative antibiotic binding site [chemical binding]; other site
443254002579	L25 interface [polypeptide binding]; other site
443254002580	L27 interface [polypeptide binding]; other site
443254002581	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
443254002582	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
443254002583	G-X-X-G motif; other site
443254002584	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
443254002585	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
443254002586	putative translocon binding site; other site
443254002587	protein-rRNA interface [nucleotide binding]; other site
443254002588	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
443254002589	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
443254002590	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
443254002591	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
443254002592	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
443254002593	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
443254002594	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
443254002595	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
443254002596	elongation factor Tu; Reviewed; Region: PRK00049
443254002597	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
443254002598	G1 box; other site
443254002599	GEF interaction site [polypeptide binding]; other site
443254002600	GTP/Mg2+ binding site [chemical binding]; other site
443254002601	Switch I region; other site
443254002602	G2 box; other site
443254002603	G3 box; other site
443254002604	Switch II region; other site
443254002605	G4 box; other site
443254002606	G5 box; other site
443254002607	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
443254002608	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
443254002609	Antibiotic Binding Site [chemical binding]; other site
443254002610	elongation factor G; Reviewed; Region: PRK00007
443254002611	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
443254002612	G1 box; other site
443254002613	putative GEF interaction site [polypeptide binding]; other site
443254002614	GTP/Mg2+ binding site [chemical binding]; other site
443254002615	Switch I region; other site
443254002616	G2 box; other site
443254002617	G3 box; other site
443254002618	Switch II region; other site
443254002619	G4 box; other site
443254002620	G5 box; other site
443254002621	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
443254002622	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
443254002623	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
443254002624	30S ribosomal protein S7; Validated; Region: PRK05302
443254002625	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
443254002626	S17 interaction site [polypeptide binding]; other site
443254002627	S8 interaction site; other site
443254002628	16S rRNA interaction site [nucleotide binding]; other site
443254002629	streptomycin interaction site [chemical binding]; other site
443254002630	23S rRNA interaction site [nucleotide binding]; other site
443254002631	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
443254002632	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
443254002633	thiS-thiF/thiG interaction site; other site
443254002634	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
443254002635	ThiS interaction site; other site
443254002636	putative active site [active]
443254002637	tetramer interface [polypeptide binding]; other site
443254002638	thiazole biosynthesis protein ThiH; Region: thiH; TIGR02351
443254002639	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254002640	FeS/SAM binding site; other site
443254002641	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
443254002642	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
443254002643	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
443254002644	phosphomethylpyrimidine kinase; Provisional; Region: PRK08573
443254002645	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
443254002646	substrate binding site [chemical binding]; other site
443254002647	ATP binding site [chemical binding]; other site
443254002648	Putative aldolase; Region: Aldolase_2; pfam10120
443254002649	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
443254002650	active site
443254002651	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
443254002652	Major Facilitator Superfamily; Region: MFS_1; pfam07690
443254002653	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
443254002654	putative substrate translocation pore; other site
443254002655	hypothetical protein; Validated; Region: PRK06840
443254002656	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
443254002657	active site
443254002658	4Fe-4S binding domain; Region: Fer4_6; pfam12837
443254002659	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
443254002660	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
443254002661	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254002662	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254002663	dimer interface [polypeptide binding]; other site
443254002664	putative CheW interface [polypeptide binding]; other site
443254002665	myosin-cross-reactive antigen; Provisional; Region: PRK13977
443254002666	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
443254002667	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
443254002668	Fic family protein [Function unknown]; Region: COG3177
443254002669	Fic/DOC family; Region: Fic; pfam02661
443254002670	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254002671	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254002672	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
443254002673	Walker A/P-loop; other site
443254002674	ATP binding site [chemical binding]; other site
443254002675	Q-loop/lid; other site
443254002676	ABC transporter signature motif; other site
443254002677	Walker B; other site
443254002678	D-loop; other site
443254002679	H-loop/switch region; other site
443254002680	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254002681	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254002682	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254002683	Walker A/P-loop; other site
443254002684	ATP binding site [chemical binding]; other site
443254002685	Q-loop/lid; other site
443254002686	ABC transporter signature motif; other site
443254002687	Walker B; other site
443254002688	D-loop; other site
443254002689	H-loop/switch region; other site
443254002690	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
443254002691	MarR family; Region: MarR; pfam01047
443254002692	Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031
443254002693	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254002694	FeS/SAM binding site; other site
443254002695	Helix-hairpin-helix motif; Region: HHH; pfam00633
443254002696	Transposase, Mutator family; Region: Transposase_mut; pfam00872
443254002697	MULE transposase domain; Region: MULE; pfam10551
443254002698	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
443254002699	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254002700	ATP binding site [chemical binding]; other site
443254002701	Mg2+ binding site [ion binding]; other site
443254002702	G-X-G motif; other site
443254002703	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
443254002704	ATP binding site [chemical binding]; other site
443254002705	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
443254002706	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
443254002707	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
443254002708	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
443254002709	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
443254002710	active site
443254002711	metal binding site [ion binding]; metal-binding site
443254002712	dimerization interface [polypeptide binding]; other site
443254002713	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254002714	FeS/SAM binding site; other site
443254002715	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
443254002716	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254002717	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254002718	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
443254002719	Walker A/P-loop; other site
443254002720	ATP binding site [chemical binding]; other site
443254002721	Q-loop/lid; other site
443254002722	ABC transporter signature motif; other site
443254002723	Walker B; other site
443254002724	D-loop; other site
443254002725	H-loop/switch region; other site
443254002726	Archaeal ATPase; Region: Arch_ATPase; pfam01637
443254002727	AAA ATPase domain; Region: AAA_16; pfam13191
443254002728	radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115
443254002729	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254002730	FeS/SAM binding site; other site
443254002731	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
443254002732	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
443254002733	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
443254002734	Walker A/P-loop; other site
443254002735	ATP binding site [chemical binding]; other site
443254002736	Q-loop/lid; other site
443254002737	ABC transporter signature motif; other site
443254002738	Walker B; other site
443254002739	D-loop; other site
443254002740	H-loop/switch region; other site
443254002741	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
443254002742	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254002743	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
443254002744	Walker A/P-loop; other site
443254002745	ATP binding site [chemical binding]; other site
443254002746	Q-loop/lid; other site
443254002747	ABC transporter signature motif; other site
443254002748	Walker B; other site
443254002749	D-loop; other site
443254002750	H-loop/switch region; other site
443254002751	Archaeal ATPase; Region: Arch_ATPase; pfam01637
443254002752	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254002753	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
443254002754	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254002755	Walker A/P-loop; other site
443254002756	ATP binding site [chemical binding]; other site
443254002757	Q-loop/lid; other site
443254002758	ABC transporter signature motif; other site
443254002759	Walker B; other site
443254002760	D-loop; other site
443254002761	H-loop/switch region; other site
443254002762	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09318
443254002763	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
443254002764	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
443254002765	dimerization interface [polypeptide binding]; other site
443254002766	active site
443254002767	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
443254002768	homopentamer interface [polypeptide binding]; other site
443254002769	active site
443254002770	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
443254002771	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
443254002772	catalytic motif [active]
443254002773	Zn binding site [ion binding]; other site
443254002774	RibD C-terminal domain; Region: RibD_C; cl17279
443254002775	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
443254002776	Lumazine binding domain; Region: Lum_binding; pfam00677
443254002777	Lumazine binding domain; Region: Lum_binding; pfam00677
443254002778	asparagine synthetase A; Reviewed; Region: PRK06462
443254002779	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
443254002780	motif 1; other site
443254002781	dimer interface [polypeptide binding]; other site
443254002782	active site
443254002783	motif 2; other site
443254002784	motif 3; other site
443254002785	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
443254002786	Protein of unknown function DUF58; Region: DUF58; pfam01882
443254002787	MoxR-like ATPases [General function prediction only]; Region: COG0714
443254002788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254002789	Walker A motif; other site
443254002790	ATP binding site [chemical binding]; other site
443254002791	Walker B motif; other site
443254002792	arginine finger; other site
443254002793	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
443254002794	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
443254002795	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
443254002796	IHF dimer interface [polypeptide binding]; other site
443254002797	IHF - DNA interface [nucleotide binding]; other site
443254002798	Methyltransferase domain; Region: Methyltransf_31; pfam13847
443254002799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254002800	S-adenosylmethionine binding site [chemical binding]; other site
443254002801	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
443254002802	Fe-S cluster binding site [ion binding]; other site
443254002803	active site
443254002804	Predicted permeases [General function prediction only]; Region: COG0795
443254002805	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
443254002806	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
443254002807	PhoU domain; Region: PhoU; pfam01895
443254002808	PhoU domain; Region: PhoU; pfam01895
443254002809	ATP-NAD kinase; Region: NAD_kinase; pfam01513
443254002810	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
443254002811	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
443254002812	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
443254002813	catalytic residue [active]
443254002814	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
443254002815	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254002816	Walker A motif; other site
443254002817	ATP binding site [chemical binding]; other site
443254002818	Walker B motif; other site
443254002819	arginine finger; other site
443254002820	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
443254002821	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
443254002822	RIP metalloprotease RseP; Region: TIGR00054
443254002823	active site
443254002824	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
443254002825	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
443254002826	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
443254002827	putative substrate binding region [chemical binding]; other site
443254002828	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
443254002829	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
443254002830	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
443254002831	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254002832	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254002833	metal binding site [ion binding]; metal-binding site
443254002834	active site
443254002835	I-site; other site
443254002836	diaminopimelate aminotransferase; Provisional; Region: PRK13983
443254002837	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650
443254002838	metal binding site [ion binding]; metal-binding site
443254002839	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
443254002840	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
443254002841	metal binding site [ion binding]; metal-binding site
443254002842	dimer interface [polypeptide binding]; other site
443254002843	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
443254002844	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
443254002845	active site
443254002846	putative substrate binding pocket [chemical binding]; other site
443254002847	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
443254002848	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
443254002849	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
443254002850	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
443254002851	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
443254002852	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
443254002853	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
443254002854	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
443254002855	PHP domain; Region: PHP; pfam02811
443254002856	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
443254002857	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
443254002858	Coenzyme A binding pocket [chemical binding]; other site
443254002859	oxaloacetate decarboxylase; Provisional; Region: PRK14041
443254002860	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
443254002861	active site
443254002862	catalytic residues [active]
443254002863	metal binding site [ion binding]; metal-binding site
443254002864	homodimer binding site [polypeptide binding]; other site
443254002865	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
443254002866	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
443254002867	ligand binding site [chemical binding]; other site
443254002868	flexible hinge region; other site
443254002869	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
443254002870	putative switch regulator; other site
443254002871	non-specific DNA interactions [nucleotide binding]; other site
443254002872	DNA binding site [nucleotide binding]
443254002873	sequence specific DNA binding site [nucleotide binding]; other site
443254002874	putative cAMP binding site [chemical binding]; other site
443254002875	Predicted permease; Region: DUF318; cl17795
443254002876	Putative Fe-S cluster; Region: FeS; pfam04060
443254002877	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
443254002878	metal binding site 2 [ion binding]; metal-binding site
443254002879	putative DNA binding helix; other site
443254002880	metal binding site 1 [ion binding]; metal-binding site
443254002881	dimer interface [polypeptide binding]; other site
443254002882	structural Zn2+ binding site [ion binding]; other site
443254002883	transcription termination factor NusA; Region: NusA; TIGR01953
443254002884	NusA N-terminal domain; Region: NusA_N; pfam08529
443254002885	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
443254002886	RNA binding site [nucleotide binding]; other site
443254002887	homodimer interface [polypeptide binding]; other site
443254002888	NusA-like KH domain; Region: KH_5; pfam13184
443254002889	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
443254002890	G-X-X-G motif; other site
443254002891	ribosome maturation protein RimP; Reviewed; Region: PRK00092
443254002892	Sm and related proteins; Region: Sm_like; cl00259
443254002893	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
443254002894	putative oligomer interface [polypeptide binding]; other site
443254002895	putative RNA binding site [nucleotide binding]; other site
443254002896	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
443254002897	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
443254002898	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
443254002899	Domain of unknown function (DUF814); Region: DUF814; pfam05670
443254002900	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
443254002901	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
443254002902	active site
443254002903	FMN binding site [chemical binding]; other site
443254002904	substrate binding site [chemical binding]; other site
443254002905	putative catalytic residue [active]
443254002906	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
443254002907	Ferredoxin [Energy production and conversion]; Region: COG1146
443254002908	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
443254002909	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
443254002910	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
443254002911	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
443254002912	P loop nucleotide binding; other site
443254002913	switch II; other site
443254002914	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
443254002915	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
443254002916	switch II; other site
443254002917	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
443254002918	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
443254002919	GDP-binding site [chemical binding]; other site
443254002920	ACT binding site; other site
443254002921	IMP binding site; other site
443254002922	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
443254002923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254002924	S-adenosylmethionine binding site [chemical binding]; other site
443254002925	Domain of unknown function DUF20; Region: UPF0118; pfam01594
443254002926	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
443254002927	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
443254002928	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
443254002929	DHH family; Region: DHH; pfam01368
443254002930	DHHA1 domain; Region: DHHA1; pfam02272
443254002931	Clp protease ATP binding subunit; Region: clpC; CHL00095
443254002932	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254002933	Walker A motif; other site
443254002934	ATP binding site [chemical binding]; other site
443254002935	Walker B motif; other site
443254002936	arginine finger; other site
443254002937	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254002938	Walker A motif; other site
443254002939	ATP binding site [chemical binding]; other site
443254002940	Walker B motif; other site
443254002941	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
443254002942	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
443254002943	Flagellar L-ring protein; Region: FlgH; cl17277
443254002944	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
443254002945	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
443254002946	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
443254002947	anti sigma factor interaction site; other site
443254002948	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
443254002949	regulatory phosphorylation site [posttranslational modification]; other site
443254002950	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
443254002951	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
443254002952	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
443254002953	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
443254002954	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
443254002955	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
443254002956	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
443254002957	Mechanosensitive ion channel; Region: MS_channel; pfam00924
443254002958	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
443254002959	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
443254002960	homotetramer interface [polypeptide binding]; other site
443254002961	ligand binding site [chemical binding]; other site
443254002962	catalytic site [active]
443254002963	NAD binding site [chemical binding]; other site
443254002964	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254002965	Radical SAM superfamily; Region: Radical_SAM; pfam04055
443254002966	FeS/SAM binding site; other site
443254002967	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
443254002968	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
443254002969	Walker A/P-loop; other site
443254002970	ATP binding site [chemical binding]; other site
443254002971	Q-loop/lid; other site
443254002972	ABC transporter signature motif; other site
443254002973	Walker B; other site
443254002974	D-loop; other site
443254002975	H-loop/switch region; other site
443254002976	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
443254002977	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
443254002978	ABC-ATPase subunit  interface; other site
443254002979	dimer interface [polypeptide binding]; other site
443254002980	putative PBP binding regions; other site
443254002981	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
443254002982	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
443254002983	intersubunit interface [polypeptide binding]; other site
443254002984	FOG: WD40-like repeat [Function unknown]; Region: COG1520
443254002985	LVIVD repeat; Region: LVIVD; pfam08309
443254002986	LVIVD repeat; Region: LVIVD; pfam08309
443254002987	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
443254002988	Interdomain contacts; other site
443254002989	Cytokine receptor motif; other site
443254002990	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
443254002991	Trp docking motif [polypeptide binding]; other site
443254002992	FOG: WD40-like repeat [Function unknown]; Region: COG1520
443254002993	active site
443254002994	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
443254002995	Interdomain contacts; other site
443254002996	Cytokine receptor motif; other site
443254002997	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
443254002998	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
443254002999	Carbon starvation protein CstA; Region: CstA; pfam02554
443254003000	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
443254003001	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
443254003002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254003003	active site
443254003004	phosphorylation site [posttranslational modification]
443254003005	intermolecular recognition site; other site
443254003006	dimerization interface [polypeptide binding]; other site
443254003007	LytTr DNA-binding domain; Region: LytTR; smart00850
443254003008	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
443254003009	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
443254003010	Histidine kinase; Region: His_kinase; pfam06580
443254003011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
443254003012	ATP binding site [chemical binding]; other site
443254003013	Mg2+ binding site [ion binding]; other site
443254003014	G-X-G motif; other site
443254003015	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
443254003016	catalytic loop [active]
443254003017	iron binding site [ion binding]; other site
443254003018	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
443254003019	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
443254003020	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
443254003021	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
443254003022	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
443254003023	SLBB domain; Region: SLBB; pfam10531
443254003024	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
443254003025	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
443254003026	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
443254003027	putative dimer interface [polypeptide binding]; other site
443254003028	[2Fe-2S] cluster binding site [ion binding]; other site
443254003029	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
443254003030	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
443254003031	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
443254003032	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
443254003033	dimer interface [polypeptide binding]; other site
443254003034	active site
443254003035	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
443254003036	dimer interface [polypeptide binding]; other site
443254003037	active site
443254003038	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
443254003039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254003040	dimer interface [polypeptide binding]; other site
443254003041	conserved gate region; other site
443254003042	putative PBP binding loops; other site
443254003043	ABC-ATPase subunit interface; other site
443254003044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254003045	dimer interface [polypeptide binding]; other site
443254003046	conserved gate region; other site
443254003047	putative PBP binding loops; other site
443254003048	ABC-ATPase subunit interface; other site
443254003049	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
443254003050	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
443254003051	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
443254003052	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
443254003053	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
443254003054	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
443254003055	nucleotide binding site [chemical binding]; other site
443254003056	AAA domain; Region: AAA_14; pfam13173
443254003057	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254003058	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
443254003059	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
443254003060	substrate binding site [chemical binding]; other site
443254003061	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
443254003062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254003063	dimer interface [polypeptide binding]; other site
443254003064	conserved gate region; other site
443254003065	putative PBP binding loops; other site
443254003066	ABC-ATPase subunit interface; other site
443254003067	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
443254003068	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254003069	dimer interface [polypeptide binding]; other site
443254003070	conserved gate region; other site
443254003071	putative PBP binding loops; other site
443254003072	ABC-ATPase subunit interface; other site
443254003073	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
443254003074	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
443254003075	Walker A/P-loop; other site
443254003076	ATP binding site [chemical binding]; other site
443254003077	Q-loop/lid; other site
443254003078	ABC transporter signature motif; other site
443254003079	Walker B; other site
443254003080	D-loop; other site
443254003081	H-loop/switch region; other site
443254003082	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
443254003083	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
443254003084	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
443254003085	Walker A/P-loop; other site
443254003086	ATP binding site [chemical binding]; other site
443254003087	Q-loop/lid; other site
443254003088	ABC transporter signature motif; other site
443254003089	Walker B; other site
443254003090	D-loop; other site
443254003091	H-loop/switch region; other site
443254003092	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
443254003093	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
443254003094	beta-galactosidase; Region: BGL; TIGR03356
443254003095	Transcriptional regulators [Transcription]; Region: PurR; COG1609
443254003096	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
443254003097	DNA binding site [nucleotide binding]
443254003098	domain linker motif; other site
443254003099	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
443254003100	dimerization interface [polypeptide binding]; other site
443254003101	ligand binding site [chemical binding]; other site
443254003102	EDD domain protein, DegV family; Region: DegV; TIGR00762
443254003103	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
443254003104	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
443254003105	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
443254003106	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
443254003107	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
443254003108	minor groove reading motif; other site
443254003109	helix-hairpin-helix signature motif; other site
443254003110	substrate binding pocket [chemical binding]; other site
443254003111	active site
443254003112	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
443254003113	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
443254003114	binding surface
443254003115	TPR motif; other site
443254003116	Tetratricopeptide repeat; Region: TPR_16; pfam13432
443254003117	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254003118	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254003119	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
443254003120	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
443254003121	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
443254003122	active site
443254003123	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
443254003124	AAA domain; Region: AAA_14; pfam13173
443254003125	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
443254003126	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254003127	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
443254003128	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
443254003129	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
443254003130	motif II; other site
443254003131	Transcriptional regulators [Transcription]; Region: PurR; COG1609
443254003132	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
443254003133	DNA binding site [nucleotide binding]
443254003134	domain linker motif; other site
443254003135	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
443254003136	dimerization interface [polypeptide binding]; other site
443254003137	ligand binding site [chemical binding]; other site
443254003138	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
443254003139	beta-galactosidase; Region: BGL; TIGR03356
443254003140	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
443254003141	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
443254003142	Walker A/P-loop; other site
443254003143	ATP binding site [chemical binding]; other site
443254003144	Q-loop/lid; other site
443254003145	ABC transporter signature motif; other site
443254003146	Walker B; other site
443254003147	D-loop; other site
443254003148	H-loop/switch region; other site
443254003149	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
443254003150	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
443254003151	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
443254003152	Walker A/P-loop; other site
443254003153	ATP binding site [chemical binding]; other site
443254003154	Q-loop/lid; other site
443254003155	ABC transporter signature motif; other site
443254003156	Walker B; other site
443254003157	D-loop; other site
443254003158	H-loop/switch region; other site
443254003159	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
443254003160	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
443254003161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254003162	dimer interface [polypeptide binding]; other site
443254003163	conserved gate region; other site
443254003164	putative PBP binding loops; other site
443254003165	ABC-ATPase subunit interface; other site
443254003166	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
443254003167	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254003168	dimer interface [polypeptide binding]; other site
443254003169	conserved gate region; other site
443254003170	putative PBP binding loops; other site
443254003171	ABC-ATPase subunit interface; other site
443254003172	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
443254003173	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
443254003174	substrate binding site [chemical binding]; other site
443254003175	AAA domain; Region: AAA_32; pfam13654
443254003176	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
443254003177	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
443254003178	active site
443254003179	DNA binding site [nucleotide binding]
443254003180	Int/Topo IB signature motif; other site
443254003181	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
443254003182	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
443254003183	substrate binding pocket [chemical binding]; other site
443254003184	membrane-bound complex binding site; other site
443254003185	hinge residues; other site
443254003186	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254003187	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254003188	Zn2+ binding site [ion binding]; other site
443254003189	Mg2+ binding site [ion binding]; other site
443254003190	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
443254003191	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254003192	dimerization interface [polypeptide binding]; other site
443254003193	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254003194	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254003195	dimer interface [polypeptide binding]; other site
443254003196	putative CheW interface [polypeptide binding]; other site
443254003197	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
443254003198	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
443254003199	Substrate binding site; other site
443254003200	Cupin domain; Region: Cupin_2; cl17218
443254003201	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
443254003202	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
443254003203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
443254003204	Uncharacterized conserved protein [Function unknown]; Region: COG1739
443254003205	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
443254003206	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
443254003207	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
443254003208	alanine racemase; Reviewed; Region: alr; PRK00053
443254003209	active site
443254003210	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
443254003211	dimer interface [polypeptide binding]; other site
443254003212	substrate binding site [chemical binding]; other site
443254003213	catalytic residues [active]
443254003214	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
443254003215	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
443254003216	generic binding surface I; other site
443254003217	generic binding surface II; other site
443254003218	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254003219	Zn2+ binding site [ion binding]; other site
443254003220	Mg2+ binding site [ion binding]; other site
443254003221	DNA topoisomerase I; Validated; Region: PRK06599
443254003222	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
443254003223	active site
443254003224	interdomain interaction site; other site
443254003225	putative metal-binding site [ion binding]; other site
443254003226	nucleotide binding site [chemical binding]; other site
443254003227	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
443254003228	domain I; other site
443254003229	DNA binding groove [nucleotide binding]
443254003230	phosphate binding site [ion binding]; other site
443254003231	domain II; other site
443254003232	domain III; other site
443254003233	nucleotide binding site [chemical binding]; other site
443254003234	catalytic site [active]
443254003235	domain IV; other site
443254003236	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
443254003237	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
443254003238	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
443254003239	D-alanyl-alanine synthetase A; Provisional; Region: PRK14571
443254003240	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
443254003241	ATP-grasp domain; Region: ATP-grasp_4; cl17255
443254003242	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
443254003243	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254003244	FeS/SAM binding site; other site
443254003245	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
443254003246	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
443254003247	active site
443254003248	NAD binding site [chemical binding]; other site
443254003249	metal binding site [ion binding]; metal-binding site
443254003250	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
443254003251	catalytic core [active]
443254003252	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
443254003253	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
443254003254	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
443254003255	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
443254003256	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
443254003257	CoA-ligase; Region: Ligase_CoA; pfam00549
443254003258	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
443254003259	CoA binding domain; Region: CoA_binding; smart00881
443254003260	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
443254003261	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
443254003262	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
443254003263	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
443254003264	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
443254003265	GAF domain; Region: GAF_3; pfam13492
443254003266	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254003267	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254003268	Zn2+ binding site [ion binding]; other site
443254003269	Mg2+ binding site [ion binding]; other site
443254003270	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
443254003271	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
443254003272	substrate binding pocket [chemical binding]; other site
443254003273	membrane-bound complex binding site; other site
443254003274	hinge residues; other site
443254003275	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
443254003276	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
443254003277	oligomerization interface [polypeptide binding]; other site
443254003278	active site
443254003279	metal binding site [ion binding]; metal-binding site
443254003280	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
443254003281	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
443254003282	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
443254003283	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
443254003284	active site
443254003285	purine nucleoside phosphorylase; Provisional; Region: PRK08202
443254003286	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
443254003287	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
443254003288	N-acetyl-D-glucosamine binding site [chemical binding]; other site
443254003289	catalytic residue [active]
443254003290	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
443254003291	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
443254003292	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
443254003293	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
443254003294	MgtE intracellular N domain; Region: MgtE_N; cl15244
443254003295	FliG C-terminal domain; Region: FliG_C; pfam01706
443254003296	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
443254003297	Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157
443254003298	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
443254003299	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
443254003300	Walker A motif/ATP binding site; other site
443254003301	Walker B motif; other site
443254003302	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
443254003303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254003304	dimer interface [polypeptide binding]; other site
443254003305	conserved gate region; other site
443254003306	putative PBP binding loops; other site
443254003307	ABC-ATPase subunit interface; other site
443254003308	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
443254003309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254003310	dimer interface [polypeptide binding]; other site
443254003311	conserved gate region; other site
443254003312	putative PBP binding loops; other site
443254003313	ABC-ATPase subunit interface; other site
443254003314	Brix domain; Region: Brix; cl00935
443254003315	MraW methylase family; Region: Methyltransf_5; cl17771
443254003316	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
443254003317	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
443254003318	bacterial Hfq-like; Region: Hfq; cd01716
443254003319	hexamer interface [polypeptide binding]; other site
443254003320	Sm1 motif; other site
443254003321	RNA binding site [nucleotide binding]; other site
443254003322	Sm2 motif; other site
443254003323	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
443254003324	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
443254003325	HflX GTPase family; Region: HflX; cd01878
443254003326	G1 box; other site
443254003327	GTP/Mg2+ binding site [chemical binding]; other site
443254003328	Switch I region; other site
443254003329	G2 box; other site
443254003330	G3 box; other site
443254003331	Switch II region; other site
443254003332	G4 box; other site
443254003333	G5 box; other site
443254003334	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
443254003335	Peptidase family M23; Region: Peptidase_M23; pfam01551
443254003336	S-adenosylmethionine synthetase; Validated; Region: PRK05250
443254003337	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
443254003338	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
443254003339	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
443254003340	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
443254003341	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
443254003342	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
443254003343	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
443254003344	NAD(P) binding pocket [chemical binding]; other site
443254003345	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
443254003346	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
443254003347	active site
443254003348	metal binding site [ion binding]; metal-binding site
443254003349	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
443254003350	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
443254003351	predicted active site [active]
443254003352	catalytic triad [active]
443254003353	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
443254003354	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
443254003355	active site
443254003356	multimer interface [polypeptide binding]; other site
443254003357	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
443254003358	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
443254003359	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
443254003360	active site
443254003361	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
443254003362	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
443254003363	DNA binding site [nucleotide binding]
443254003364	active site
443254003365	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
443254003366	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
443254003367	active site
443254003368	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
443254003369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254003370	dimer interface [polypeptide binding]; other site
443254003371	conserved gate region; other site
443254003372	putative PBP binding loops; other site
443254003373	ABC-ATPase subunit interface; other site
443254003374	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
443254003375	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254003376	dimer interface [polypeptide binding]; other site
443254003377	conserved gate region; other site
443254003378	putative PBP binding loops; other site
443254003379	ABC-ATPase subunit interface; other site
443254003380	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
443254003381	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
443254003382	LabA_like proteins; Region: LabA_like; cd06167
443254003383	Uncharacterized conserved protein [Function unknown]; Region: COG1432
443254003384	putative metal binding site [ion binding]; other site
443254003385	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
443254003386	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
443254003387	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
443254003388	dimer interface [polypeptide binding]; other site
443254003389	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254003390	catalytic residue [active]
443254003391	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
443254003392	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
443254003393	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
443254003394	Uncharacterized conserved protein [Function unknown]; Region: COG2006
443254003395	Domain of unknown function (DUF362); Region: DUF362; pfam04015
443254003396	4Fe-4S binding domain; Region: Fer4; pfam00037
443254003397	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
443254003398	4Fe-4S binding domain; Region: Fer4; pfam00037
443254003399	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
443254003400	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
443254003401	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
443254003402	non-specific DNA binding site [nucleotide binding]; other site
443254003403	salt bridge; other site
443254003404	sequence-specific DNA binding site [nucleotide binding]; other site
443254003405	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
443254003406	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
443254003407	phosphate binding site [ion binding]; other site
443254003408	4Fe-4S binding domain; Region: Fer4; pfam00037
443254003409	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
443254003410	4Fe-4S binding domain; Region: Fer4; pfam00037
443254003411	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
443254003412	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
443254003413	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
443254003414	active site
443254003415	nucleophile elbow; other site
443254003416	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254003417	Walker A motif; other site
443254003418	ATP binding site [chemical binding]; other site
443254003419	Walker B motif; other site
443254003420	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
443254003421	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
443254003422	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
443254003423	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
443254003424	ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879
443254003425	L-serine binding site [chemical binding]; other site
443254003426	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
443254003427	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
443254003428	peroxiredoxin; Provisional; Region: PRK13189
443254003429	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
443254003430	dimer interface [polypeptide binding]; other site
443254003431	decamer (pentamer of dimers) interface [polypeptide binding]; other site
443254003432	catalytic triad [active]
443254003433	Cache domain; Region: Cache_1; pfam02743
443254003434	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254003435	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254003436	Zn2+ binding site [ion binding]; other site
443254003437	Mg2+ binding site [ion binding]; other site
443254003438	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
443254003439	Heme NO binding; Region: HNOB; pfam07700
443254003440	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254003441	dimer interface [polypeptide binding]; other site
443254003442	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254003443	putative CheW interface [polypeptide binding]; other site
443254003444	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
443254003445	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
443254003446	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
443254003447	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
443254003448	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
443254003449	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
443254003450	active site
443254003451	homodimer interface [polypeptide binding]; other site
443254003452	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
443254003453	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
443254003454	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
443254003455	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
443254003456	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
443254003457	putative trimer interface [polypeptide binding]; other site
443254003458	putative CoA binding site [chemical binding]; other site
443254003459	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
443254003460	putative CoA binding site [chemical binding]; other site
443254003461	putative trimer interface [polypeptide binding]; other site
443254003462	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
443254003463	putative trimer interface [polypeptide binding]; other site
443254003464	putative active site [active]
443254003465	putative substrate binding site [chemical binding]; other site
443254003466	putative CoA binding site [chemical binding]; other site
443254003467	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
443254003468	HAMP domain; Region: HAMP; pfam00672
443254003469	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254003470	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254003471	dimer interface [polypeptide binding]; other site
443254003472	putative CheW interface [polypeptide binding]; other site
443254003473	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
443254003474	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
443254003475	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
443254003476	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
443254003477	MoaE interaction surface [polypeptide binding]; other site
443254003478	MoeB interaction surface [polypeptide binding]; other site
443254003479	thiocarboxylated glycine; other site
443254003480	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
443254003481	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
443254003482	dimer interface [polypeptide binding]; other site
443254003483	putative functional site; other site
443254003484	putative MPT binding site; other site
443254003485	PBP superfamily domain; Region: PBP_like; pfam12727
443254003486	threonine synthase; Validated; Region: PRK06260
443254003487	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
443254003488	iron binding site [ion binding]; other site
443254003489	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
443254003490	homodimer interface [polypeptide binding]; other site
443254003491	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254003492	catalytic residue [active]
443254003493	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
443254003494	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
443254003495	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
443254003496	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
443254003497	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
443254003498	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
443254003499	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
443254003500	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
443254003501	catalytic loop [active]
443254003502	iron binding site [ion binding]; other site
443254003503	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
443254003504	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
443254003505	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
443254003506	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
443254003507	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
443254003508	homotrimer interaction site [polypeptide binding]; other site
443254003509	putative active site [active]
443254003510	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
443254003511	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
443254003512	RNA binding surface [nucleotide binding]; other site
443254003513	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
443254003514	active site
443254003515	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
443254003516	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
443254003517	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
443254003518	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
443254003519	trimer interface [polypeptide binding]; other site
443254003520	active site
443254003521	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
443254003522	catalytic site [active]
443254003523	AAA domain; Region: AAA_23; pfam13476
443254003524	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
443254003525	Walker A/P-loop; other site
443254003526	ATP binding site [chemical binding]; other site
443254003527	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
443254003528	Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654
443254003529	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
443254003530	ABC transporter signature motif; other site
443254003531	Walker B; other site
443254003532	D-loop; other site
443254003533	H-loop/switch region; other site
443254003534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
443254003535	putative substrate translocation pore; other site
443254003536	Major Facilitator Superfamily; Region: MFS_1; pfam07690
443254003537	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
443254003538	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
443254003539	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
443254003540	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
443254003541	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254003542	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
443254003543	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
443254003544	RloB-like protein; Region: RloB; pfam13707
443254003545	AAA domain; Region: AAA_21; pfam13304
443254003546	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254003547	Walker B; other site
443254003548	D-loop; other site
443254003549	H-loop/switch region; other site
443254003550	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254003551	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
443254003552	Protein of unknown function (DUF524); Region: DUF524; pfam04411
443254003553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
443254003554	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
443254003555	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
443254003556	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
443254003557	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254003558	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
443254003559	Radical SAM superfamily; Region: Radical_SAM; pfam04055
443254003560	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254003561	FeS/SAM binding site; other site
443254003562	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
443254003563	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254003564	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254003565	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254003566	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
443254003567	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
443254003568	NADP binding site [chemical binding]; other site
443254003569	active site
443254003570	putative substrate binding site [chemical binding]; other site
443254003571	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
443254003572	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
443254003573	NADP-binding site; other site
443254003574	homotetramer interface [polypeptide binding]; other site
443254003575	substrate binding site [chemical binding]; other site
443254003576	homodimer interface [polypeptide binding]; other site
443254003577	active site
443254003578	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254003579	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254003580	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254003581	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
443254003582	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
443254003583	NADP binding site [chemical binding]; other site
443254003584	active site
443254003585	putative substrate binding site [chemical binding]; other site
443254003586	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
443254003587	trimer interface [polypeptide binding]; other site
443254003588	active site
443254003589	substrate binding site [chemical binding]; other site
443254003590	CoA binding site [chemical binding]; other site
443254003591	putative glycosyl transferase; Provisional; Region: PRK10307
443254003592	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
443254003593	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
443254003594	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
443254003595	Bacterial sugar transferase; Region: Bac_transf; pfam02397
443254003596	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
443254003597	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
443254003598	active site
443254003599	HIGH motif; other site
443254003600	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
443254003601	KMSKS motif; other site
443254003602	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
443254003603	tRNA binding surface [nucleotide binding]; other site
443254003604	anticodon binding site; other site
443254003605	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
443254003606	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
443254003607	active site
443254003608	HIGH motif; other site
443254003609	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
443254003610	active site
443254003611	KMSKS motif; other site
443254003612	flagellar assembly protein H; Provisional; Region: fliH; PRK13386
443254003613	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
443254003614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254003615	active site
443254003616	phosphorylation site [posttranslational modification]
443254003617	intermolecular recognition site; other site
443254003618	dimerization interface [polypeptide binding]; other site
443254003619	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
443254003620	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
443254003621	active site
443254003622	catalytic motif [active]
443254003623	Zn binding site [ion binding]; other site
443254003624	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
443254003625	Domain of unknown function DUF21; Region: DUF21; pfam01595
443254003626	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
443254003627	Transporter associated domain; Region: CorC_HlyC; smart01091
443254003628	Uncharacterized conserved protein [Function unknown]; Region: COG1284
443254003629	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
443254003630	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
443254003631	chaperone protein DnaJ; Provisional; Region: PRK14282
443254003632	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
443254003633	HSP70 interaction site [polypeptide binding]; other site
443254003634	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
443254003635	Zn binding sites [ion binding]; other site
443254003636	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
443254003637	dimer interface [polypeptide binding]; other site
443254003638	GrpE; Region: GrpE; pfam01025
443254003639	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
443254003640	dimer interface [polypeptide binding]; other site
443254003641	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
443254003642	Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420
443254003643	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
443254003644	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
443254003645	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
443254003646	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
443254003647	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
443254003648	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
443254003649	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
443254003650	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
443254003651	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
443254003652	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
443254003653	Mg++ binding site [ion binding]; other site
443254003654	putative catalytic motif [active]
443254003655	putative substrate binding site [chemical binding]; other site
443254003656	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
443254003657	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
443254003658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254003659	ATP binding site [chemical binding]; other site
443254003660	Mg2+ binding site [ion binding]; other site
443254003661	G-X-G motif; other site
443254003662	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
443254003663	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
443254003664	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
443254003665	putative active site [active]
443254003666	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
443254003667	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
443254003668	oligomer interface [polypeptide binding]; other site
443254003669	putative active site [active]
443254003670	metal binding site [ion binding]; metal-binding site
443254003671	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
443254003672	Chain length determinant protein; Region: Wzz; pfam02706
443254003673	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
443254003674	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
443254003675	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
443254003676	PHP domain; Region: PHP; pfam02811
443254003677	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
443254003678	Chain length determinant protein; Region: Wzz; pfam02706
443254003679	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
443254003680	Bacterial sugar transferase; Region: Bac_transf; pfam02397
443254003681	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
443254003682	active site
443254003683	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
443254003684	GDP-Fucose binding site [chemical binding]; other site
443254003685	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
443254003686	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
443254003687	NADP-binding site; other site
443254003688	homotetramer interface [polypeptide binding]; other site
443254003689	substrate binding site [chemical binding]; other site
443254003690	homodimer interface [polypeptide binding]; other site
443254003691	active site
443254003692	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
443254003693	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
443254003694	NADP binding site [chemical binding]; other site
443254003695	active site
443254003696	putative substrate binding site [chemical binding]; other site
443254003697	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254003698	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
443254003699	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254003700	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
443254003701	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
443254003702	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
443254003703	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
443254003704	dimer interface [polypeptide binding]; other site
443254003705	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
443254003706	active site
443254003707	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
443254003708	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
443254003709	Substrate binding site; other site
443254003710	Mg++ binding site; other site
443254003711	metal-binding site
443254003712	Mg++ binding site; other site
443254003713	metal-binding site
443254003714	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
443254003715	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
443254003716	active site
443254003717	motif I; other site
443254003718	motif II; other site
443254003719	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
443254003720	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254003721	putative glycosyl transferase; Provisional; Region: PRK10073
443254003722	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
443254003723	active site
443254003724	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
443254003725	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
443254003726	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
443254003727	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
443254003728	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
443254003729	Bacterial sugar transferase; Region: Bac_transf; pfam02397
443254003730	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254003731	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
443254003732	putative ADP-binding pocket [chemical binding]; other site
443254003733	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254003734	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
443254003735	O-Antigen ligase; Region: Wzy_C; pfam04932
443254003736	chain length determinant protein EpsF; Region: EpsF; TIGR03017
443254003737	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254003738	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254003739	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931
443254003740	putative active site [active]
443254003741	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
443254003742	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254003743	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254003744	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
443254003745	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
443254003746	Ligand Binding Site [chemical binding]; other site
443254003747	Molecular Tunnel; other site
443254003748	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
443254003749	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
443254003750	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
443254003751	active site
443254003752	homodimer interface [polypeptide binding]; other site
443254003753	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254003754	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254003755	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
443254003756	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
443254003757	active site
443254003758	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
443254003759	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
443254003760	NAD binding site [chemical binding]; other site
443254003761	substrate binding site [chemical binding]; other site
443254003762	active site
443254003763	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
443254003764	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
443254003765	inhibitor-cofactor binding pocket; inhibition site
443254003766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254003767	catalytic residue [active]
443254003768	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
443254003769	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
443254003770	putative trimer interface [polypeptide binding]; other site
443254003771	putative CoA binding site [chemical binding]; other site
443254003772	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
443254003773	Ligand Binding Site [chemical binding]; other site
443254003774	Molecular Tunnel; other site
443254003775	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
443254003776	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
443254003777	putative active site [active]
443254003778	putative metal binding site [ion binding]; other site
443254003779	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254003780	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
443254003781	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
443254003782	Ligand binding site; other site
443254003783	UDP-glucose 4-epimerase; Region: PLN02240
443254003784	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
443254003785	NAD binding site [chemical binding]; other site
443254003786	homodimer interface [polypeptide binding]; other site
443254003787	active site
443254003788	substrate binding site [chemical binding]; other site
443254003789	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
443254003790	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
443254003791	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
443254003792	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
443254003793	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
443254003794	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
443254003795	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
443254003796	GatB domain; Region: GatB_Yqey; smart00845
443254003797	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
443254003798	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
443254003799	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
443254003800	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
443254003801	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254003802	Zn2+ binding site [ion binding]; other site
443254003803	Mg2+ binding site [ion binding]; other site
443254003804	Rhomboid family; Region: Rhomboid; pfam01694
443254003805	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
443254003806	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
443254003807	nucleotide binding site [chemical binding]; other site
443254003808	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
443254003809	substrate binding site; other site
443254003810	dimer interface; other site
443254003811	endonuclease IV; Provisional; Region: PRK01060
443254003812	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
443254003813	AP (apurinic/apyrimidinic) site pocket; other site
443254003814	DNA interaction; other site
443254003815	Metal-binding active site; metal-binding site
443254003816	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
443254003817	HflK protein; Region: hflK; TIGR01933
443254003818	HflC protein; Region: hflC; TIGR01932
443254003819	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
443254003820	Methyltransferase domain; Region: Methyltransf_31; pfam13847
443254003821	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254003822	S-adenosylmethionine binding site [chemical binding]; other site
443254003823	thymidylate kinase; Validated; Region: tmk; PRK00698
443254003824	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
443254003825	TMP-binding site; other site
443254003826	ATP-binding site [chemical binding]; other site
443254003827	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
443254003828	4Fe-4S binding domain; Region: Fer4_5; pfam12801
443254003829	4Fe-4S binding domain; Region: Fer4_5; pfam12801
443254003830	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
443254003831	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
443254003832	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
443254003833	hypothetical protein; Provisional; Region: PRK00967
443254003834	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
443254003835	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
443254003836	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
443254003837	Walker A/P-loop; other site
443254003838	ATP binding site [chemical binding]; other site
443254003839	Q-loop/lid; other site
443254003840	ABC transporter signature motif; other site
443254003841	Walker B; other site
443254003842	D-loop; other site
443254003843	H-loop/switch region; other site
443254003844	Predicted transcriptional regulators [Transcription]; Region: COG1725
443254003845	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
443254003846	DNA-binding site [nucleotide binding]; DNA binding site
443254003847	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
443254003848	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
443254003849	active site
443254003850	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254003851	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254003852	Zn2+ binding site [ion binding]; other site
443254003853	Mg2+ binding site [ion binding]; other site
443254003854	Major Facilitator Superfamily; Region: MFS_1; pfam07690
443254003855	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
443254003856	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
443254003857	Interdomain contacts; other site
443254003858	Cytokine receptor motif; other site
443254003859	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
443254003860	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
443254003861	active site
443254003862	metal binding site [ion binding]; metal-binding site
443254003863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254003864	S-adenosylmethionine binding site [chemical binding]; other site
443254003865	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
443254003866	HAMP domain; Region: HAMP; pfam00672
443254003867	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254003868	dimer interface [polypeptide binding]; other site
443254003869	putative CheW interface [polypeptide binding]; other site
443254003870	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
443254003871	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
443254003872	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254003873	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254003874	dimer interface [polypeptide binding]; other site
443254003875	putative CheW interface [polypeptide binding]; other site
443254003876	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
443254003877	DNA polymerase type-B family; Region: POLBc; smart00486
443254003878	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
443254003879	active site
443254003880	catalytic site [active]
443254003881	substrate binding site [chemical binding]; other site
443254003882	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023
443254003883	active site
443254003884	metal-binding site
443254003885	L-aspartate dehydrogenase; Provisional; Region: PRK13303
443254003886	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
443254003887	Domain of unknown function DUF108; Region: DUF108; pfam01958
443254003888	Quinolinate synthetase A protein; Region: NadA; pfam02445
443254003889	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
443254003890	nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078
443254003891	dimerization interface [polypeptide binding]; other site
443254003892	active site
443254003893	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
443254003894	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
443254003895	Walker A/P-loop; other site
443254003896	ATP binding site [chemical binding]; other site
443254003897	Q-loop/lid; other site
443254003898	ABC transporter signature motif; other site
443254003899	Walker B; other site
443254003900	D-loop; other site
443254003901	H-loop/switch region; other site
443254003902	FeS assembly protein SufB; Region: sufB; TIGR01980
443254003903	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
443254003904	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
443254003905	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
443254003906	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
443254003907	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
443254003908	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
443254003909	catalytic residue [active]
443254003910	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
443254003911	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
443254003912	trimerization site [polypeptide binding]; other site
443254003913	active site
443254003914	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
443254003915	hypothetical protein; Reviewed; Region: PRK09588
443254003916	Protein of unknown function DUF89; Region: DUF89; cl15397
443254003917	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
443254003918	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
443254003919	active site
443254003920	metal binding site [ion binding]; metal-binding site
443254003921	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
443254003922	Archaeal ATPase; Region: Arch_ATPase; pfam01637
443254003923	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
443254003924	DNA-binding site [nucleotide binding]; DNA binding site
443254003925	RNA-binding motif; other site
443254003926	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
443254003927	DNA-binding site [nucleotide binding]; DNA binding site
443254003928	RNA-binding motif; other site
443254003929	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
443254003930	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
443254003931	intersubunit interface [polypeptide binding]; other site
443254003932	active site
443254003933	catalytic residue [active]
443254003934	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
443254003935	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
443254003936	hypothetical protein; Reviewed; Region: PRK00024
443254003937	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
443254003938	MPN+ (JAMM) motif; other site
443254003939	Zinc-binding site [ion binding]; other site
443254003940	Maf-like protein; Region: Maf; pfam02545
443254003941	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
443254003942	active site
443254003943	dimer interface [polypeptide binding]; other site
443254003944	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
443254003945	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
443254003946	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
443254003947	ApbE family; Region: ApbE; pfam02424
443254003948	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
443254003949	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254003950	FeS/SAM binding site; other site
443254003951	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
443254003952	AMMECR1; Region: AMMECR1; pfam01871
443254003953	tRNA pseudouridine synthase B; Provisional; Region: PRK14124
443254003954	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
443254003955	RNA binding site [nucleotide binding]; other site
443254003956	active site
443254003957	PUA domain; Region: PUA; cl00607
443254003958	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
443254003959	HDOD domain; Region: HDOD; pfam08668
443254003960	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254003961	Zn2+ binding site [ion binding]; other site
443254003962	Mg2+ binding site [ion binding]; other site
443254003963	Dopey, N-terminal; Region: Dopey_N; cl04407
443254003964	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
443254003965	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
443254003966	dimer interface [polypeptide binding]; other site
443254003967	phosphorylation site [posttranslational modification]
443254003968	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254003969	ATP binding site [chemical binding]; other site
443254003970	Mg2+ binding site [ion binding]; other site
443254003971	G-X-G motif; other site
443254003972	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
443254003973	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
443254003974	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
443254003975	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
443254003976	Predicted dehydrogenase [General function prediction only]; Region: COG0579
443254003977	hydroxyglutarate oxidase; Provisional; Region: PRK11728
443254003978	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
443254003979	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
443254003980	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254003981	active site
443254003982	phosphorylation site [posttranslational modification]
443254003983	intermolecular recognition site; other site
443254003984	dimerization interface [polypeptide binding]; other site
443254003985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254003986	Walker A motif; other site
443254003987	ATP binding site [chemical binding]; other site
443254003988	Walker B motif; other site
443254003989	arginine finger; other site
443254003990	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
443254003991	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
443254003992	Tetratricopeptide repeat; Region: TPR_12; pfam13424
443254003993	binding surface
443254003994	TPR motif; other site
443254003995	Tetratricopeptide repeat; Region: TPR_12; pfam13424
443254003996	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
443254003997	TPR motif; other site
443254003998	binding surface
443254003999	Tetratricopeptide repeat; Region: TPR_12; pfam13424
443254004000	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
443254004001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
443254004002	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
443254004003	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
443254004004	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
443254004005	metal binding site [ion binding]; metal-binding site
443254004006	substrate binding pocket [chemical binding]; other site
443254004007	Uncharacterized conserved protein [Function unknown]; Region: COG5276
443254004008	LVIVD repeat; Region: LVIVD; pfam08309
443254004009	Uncharacterized conserved protein [Function unknown]; Region: COG5276
443254004010	LVIVD repeat; Region: LVIVD; pfam08309
443254004011	LVIVD repeat; Region: LVIVD; pfam08309
443254004012	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
443254004013	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
443254004014	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
443254004015	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
443254004016	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
443254004017	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
443254004018	G1 box; other site
443254004019	putative GEF interaction site [polypeptide binding]; other site
443254004020	GTP/Mg2+ binding site [chemical binding]; other site
443254004021	Switch I region; other site
443254004022	G2 box; other site
443254004023	G3 box; other site
443254004024	Switch II region; other site
443254004025	G4 box; other site
443254004026	G5 box; other site
443254004027	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
443254004028	Translation-initiation factor 2; Region: IF-2; pfam11987
443254004029	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
443254004030	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
443254004031	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
443254004032	inhibitor-cofactor binding pocket; inhibition site
443254004033	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254004034	catalytic residue [active]
443254004035	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
443254004036	CoA binding domain; Region: CoA_binding; cl17356
443254004037	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
443254004038	NAD(P) binding site [chemical binding]; other site
443254004039	homodimer interface [polypeptide binding]; other site
443254004040	substrate binding site [chemical binding]; other site
443254004041	active site
443254004042	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
443254004043	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
443254004044	Mg++ binding site [ion binding]; other site
443254004045	putative catalytic motif [active]
443254004046	substrate binding site [chemical binding]; other site
443254004047	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
443254004048	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
443254004049	active site
443254004050	metal-binding site [ion binding]
443254004051	active site
443254004052	nucleotide-binding site [chemical binding]; other site
443254004053	nucleotide-binding site [chemical binding]; other site
443254004054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
443254004055	Major Facilitator Superfamily; Region: MFS_1; pfam07690
443254004056	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
443254004057	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
443254004058	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
443254004059	NAD(P) binding site [chemical binding]; other site
443254004060	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
443254004061	propionate/acetate kinase; Provisional; Region: PRK12379
443254004062	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
443254004063	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
443254004064	Walker A/P-loop; other site
443254004065	ATP binding site [chemical binding]; other site
443254004066	Q-loop/lid; other site
443254004067	ABC transporter signature motif; other site
443254004068	Walker B; other site
443254004069	D-loop; other site
443254004070	H-loop/switch region; other site
443254004071	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
443254004072	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
443254004073	FtsX-like permease family; Region: FtsX; pfam02687
443254004074	FtsX-like permease family; Region: FtsX; pfam02687
443254004075	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
443254004076	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
443254004077	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
443254004078	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
443254004079	Walker A/P-loop; other site
443254004080	ATP binding site [chemical binding]; other site
443254004081	Q-loop/lid; other site
443254004082	ABC transporter signature motif; other site
443254004083	Walker B; other site
443254004084	D-loop; other site
443254004085	H-loop/switch region; other site
443254004086	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
443254004087	active site
443254004088	metal binding site [ion binding]; metal-binding site
443254004089	homotetramer interface [polypeptide binding]; other site
443254004090	rod shape-determining protein MreB; Provisional; Region: PRK13930
443254004091	MreB and similar proteins; Region: MreB_like; cd10225
443254004092	nucleotide binding site [chemical binding]; other site
443254004093	Mg binding site [ion binding]; other site
443254004094	putative protofilament interaction site [polypeptide binding]; other site
443254004095	RodZ interaction site [polypeptide binding]; other site
443254004096	Clostripain family; Region: Peptidase_C11; pfam03415
443254004097	phosphodiesterase; Provisional; Region: PRK12704
443254004098	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254004099	Zn2+ binding site [ion binding]; other site
443254004100	Mg2+ binding site [ion binding]; other site
443254004101	RecX family; Region: RecX; cl00936
443254004102	recombinase A; Provisional; Region: recA; PRK09354
443254004103	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
443254004104	hexamer interface [polypeptide binding]; other site
443254004105	Walker A motif; other site
443254004106	ATP binding site [chemical binding]; other site
443254004107	Walker B motif; other site
443254004108	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
443254004109	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
443254004110	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
443254004111	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
443254004112	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
443254004113	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
443254004114	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254004115	FeS/SAM binding site; other site
443254004116	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
443254004117	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
443254004118	dimer interface [polypeptide binding]; other site
443254004119	active site
443254004120	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
443254004121	substrate binding site [chemical binding]; other site
443254004122	catalytic residue [active]
443254004123	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
443254004124	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
443254004125	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
443254004126	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
443254004127	active site
443254004128	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
443254004129	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
443254004130	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
443254004131	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
443254004132	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
443254004133	putative ligand binding pocket/active site [active]
443254004134	putative metal binding site [ion binding]; other site
443254004135	Asp23 family; Region: Asp23; pfam03780
443254004136	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
443254004137	DAK2 domain; Region: Dak2; pfam02734
443254004138	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
443254004139	motif 1; other site
443254004140	dimer interface [polypeptide binding]; other site
443254004141	active site
443254004142	motif 2; other site
443254004143	motif 3; other site
443254004144	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
443254004145	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
443254004146	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
443254004147	RNase_H superfamily; Region: RNase_H_2; pfam13482
443254004148	GTPase Era; Reviewed; Region: era; PRK00089
443254004149	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
443254004150	G1 box; other site
443254004151	GTP/Mg2+ binding site [chemical binding]; other site
443254004152	Switch I region; other site
443254004153	G2 box; other site
443254004154	Switch II region; other site
443254004155	G3 box; other site
443254004156	G4 box; other site
443254004157	G5 box; other site
443254004158	KH domain; Region: KH_2; pfam07650
443254004159	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
443254004160	active site
443254004161	tetramer interface [polypeptide binding]; other site
443254004162	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
443254004163	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
443254004164	FtsX-like permease family; Region: FtsX; pfam02687
443254004165	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
443254004166	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
443254004167	Walker A/P-loop; other site
443254004168	ATP binding site [chemical binding]; other site
443254004169	Q-loop/lid; other site
443254004170	ABC transporter signature motif; other site
443254004171	Walker B; other site
443254004172	D-loop; other site
443254004173	H-loop/switch region; other site
443254004174	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
443254004175	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
443254004176	HlyD family secretion protein; Region: HlyD_3; pfam13437
443254004177	Outer membrane efflux protein; Region: OEP; pfam02321
443254004178	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
443254004179	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
443254004180	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
443254004181	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
443254004182	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
443254004183	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
443254004184	putative active site [active]
443254004185	catalytic triad [active]
443254004186	putative dimer interface [polypeptide binding]; other site
443254004187	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
443254004188	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
443254004189	Ligand Binding Site [chemical binding]; other site
443254004190	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
443254004191	active site
443254004192	metal binding site [ion binding]; metal-binding site
443254004193	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
443254004194	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
443254004195	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
443254004196	motif II; other site
443254004197	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
443254004198	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
443254004199	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
443254004200	rod shape-determining protein MreB; Provisional; Region: PRK13930
443254004201	MreB and similar proteins; Region: MreB_like; cd10225
443254004202	nucleotide binding site [chemical binding]; other site
443254004203	Mg binding site [ion binding]; other site
443254004204	putative protofilament interaction site [polypeptide binding]; other site
443254004205	RodZ interaction site [polypeptide binding]; other site
443254004206	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
443254004207	active site
443254004208	putative DNA-binding cleft [nucleotide binding]; other site
443254004209	dimer interface [polypeptide binding]; other site
443254004210	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
443254004211	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
443254004212	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
443254004213	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
443254004214	nucleotide binding region [chemical binding]; other site
443254004215	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
443254004216	ATP-binding site [chemical binding]; other site
443254004217	peptide chain release factor 2; Validated; Region: prfB; PRK00578
443254004218	This domain is found in peptide chain release factors; Region: PCRF; smart00937
443254004219	RF-1 domain; Region: RF-1; pfam00472
443254004220	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
443254004221	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_12; cd13142
443254004222	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
443254004223	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
443254004224	NAD synthetase; Provisional; Region: PRK13981
443254004225	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
443254004226	multimer interface [polypeptide binding]; other site
443254004227	active site
443254004228	catalytic triad [active]
443254004229	protein interface 1 [polypeptide binding]; other site
443254004230	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
443254004231	homodimer interface [polypeptide binding]; other site
443254004232	NAD binding pocket [chemical binding]; other site
443254004233	ATP binding pocket [chemical binding]; other site
443254004234	Mg binding site [ion binding]; other site
443254004235	active-site loop [active]
443254004236	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
443254004237	Methyltransferase domain; Region: Methyltransf_26; pfam13659
443254004238	Methyltransferase domain; Region: Methyltransf_26; pfam13659
443254004239	Ion channel; Region: Ion_trans_2; pfam07885
443254004240	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
443254004241	TrkA-N domain; Region: TrkA_N; pfam02254
443254004242	TrkA-C domain; Region: TrkA_C; pfam02080
443254004243	PQQ-like domain; Region: PQQ_2; pfam13360
443254004244	PQQ-like domain; Region: PQQ_2; pfam13360
443254004245	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
443254004246	active site
443254004247	Trp docking motif [polypeptide binding]; other site
443254004248	FOG: WD40-like repeat [Function unknown]; Region: COG1520
443254004249	FOG: WD40-like repeat [Function unknown]; Region: COG1520
443254004250	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
443254004251	active site
443254004252	Trp docking motif [polypeptide binding]; other site
443254004253	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
443254004254	dimer interface [polypeptide binding]; other site
443254004255	phosphorylation site [posttranslational modification]
443254004256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254004257	ATP binding site [chemical binding]; other site
443254004258	Mg2+ binding site [ion binding]; other site
443254004259	G-X-G motif; other site
443254004260	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
443254004261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254004262	active site
443254004263	phosphorylation site [posttranslational modification]
443254004264	intermolecular recognition site; other site
443254004265	dimerization interface [polypeptide binding]; other site
443254004266	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
443254004267	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
443254004268	ligand binding site [chemical binding]; other site
443254004269	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
443254004270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254004271	active site
443254004272	phosphorylation site [posttranslational modification]
443254004273	intermolecular recognition site; other site
443254004274	dimerization interface [polypeptide binding]; other site
443254004275	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254004276	Zn2+ binding site [ion binding]; other site
443254004277	Mg2+ binding site [ion binding]; other site
443254004278	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
443254004279	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
443254004280	intersubunit interface [polypeptide binding]; other site
443254004281	active site
443254004282	zinc binding site [ion binding]; other site
443254004283	Na+ binding site [ion binding]; other site
443254004284	Flagellar protein FliT; Region: FliT; pfam05400
443254004285	B12 binding domain; Region: B12-binding; pfam02310
443254004286	B12 binding site [chemical binding]; other site
443254004287	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
443254004288	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
443254004289	FeS/SAM binding site; other site
443254004290	pantothenate kinase; Reviewed; Region: PRK13318
443254004291	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
443254004292	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
443254004293	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
443254004294	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
443254004295	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
443254004296	non-specific DNA binding site [nucleotide binding]; other site
443254004297	salt bridge; other site
443254004298	sequence-specific DNA binding site [nucleotide binding]; other site
443254004299	Cupin domain; Region: Cupin_2; pfam07883
443254004300	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
443254004301	spermidine synthase; Provisional; Region: PRK00811
443254004302	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254004303	S-adenosylmethionine binding site [chemical binding]; other site
443254004304	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
443254004305	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
443254004306	DNA protecting protein DprA; Region: dprA; TIGR00732
443254004307	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
443254004308	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
443254004309	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
443254004310	putative hydrolase; Provisional; Region: PRK02113
443254004311	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
443254004312	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
443254004313	active site
443254004314	metal binding site [ion binding]; metal-binding site
443254004315	homotetramer interface [polypeptide binding]; other site
443254004316	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
443254004317	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
443254004318	putative dimer interface [polypeptide binding]; other site
443254004319	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
443254004320	Transposase; Region: DEDD_Tnp_IS110; pfam01548
443254004321	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
443254004322	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
443254004323	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
443254004324	AAA domain; Region: AAA_18; pfam13238
443254004325	ATP-binding site [chemical binding]; other site
443254004326	Sugar specificity; other site
443254004327	Pyrimidine base specificity; other site
443254004328	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
443254004329	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
443254004330	ligand binding site [chemical binding]; other site
443254004331	flexible hinge region; other site
443254004332	Ion channel; Region: Ion_trans_2; pfam07885
443254004333	TrkA-N domain; Region: TrkA_N; pfam02254
443254004334	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
443254004335	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254004336	dimerization interface [polypeptide binding]; other site
443254004337	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254004338	dimer interface [polypeptide binding]; other site
443254004339	putative CheW interface [polypeptide binding]; other site
443254004340	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
443254004341	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
443254004342	RNase E interface [polypeptide binding]; other site
443254004343	trimer interface [polypeptide binding]; other site
443254004344	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
443254004345	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
443254004346	RNase E interface [polypeptide binding]; other site
443254004347	trimer interface [polypeptide binding]; other site
443254004348	active site
443254004349	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
443254004350	putative nucleic acid binding region [nucleotide binding]; other site
443254004351	G-X-X-G motif; other site
443254004352	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
443254004353	RNA binding site [nucleotide binding]; other site
443254004354	domain interface; other site
443254004355	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
443254004356	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
443254004357	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
443254004358	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254004359	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254004360	Zn2+ binding site [ion binding]; other site
443254004361	Mg2+ binding site [ion binding]; other site
443254004362	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254004363	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254004364	Zn2+ binding site [ion binding]; other site
443254004365	Mg2+ binding site [ion binding]; other site
443254004366	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254004367	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254004368	Zn2+ binding site [ion binding]; other site
443254004369	Mg2+ binding site [ion binding]; other site
443254004370	Transcriptional regulators [Transcription]; Region: MarR; COG1846
443254004371	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
443254004372	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
443254004373	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
443254004374	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
443254004375	inhibitor-cofactor binding pocket; inhibition site
443254004376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254004377	catalytic residue [active]
443254004378	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
443254004379	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
443254004380	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
443254004381	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
443254004382	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
443254004383	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
443254004384	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
443254004385	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
443254004386	30S subunit binding site; other site
443254004387	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
443254004388	Ligand binding site; other site
443254004389	metal-binding site
443254004390	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
443254004391	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
443254004392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254004393	dimer interface [polypeptide binding]; other site
443254004394	conserved gate region; other site
443254004395	putative PBP binding loops; other site
443254004396	ABC-ATPase subunit interface; other site
443254004397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
443254004398	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
443254004399	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
443254004400	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
443254004401	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
443254004402	active site
443254004403	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
443254004404	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
443254004405	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
443254004406	ligand binding site [chemical binding]; other site
443254004407	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
443254004408	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
443254004409	Walker A/P-loop; other site
443254004410	ATP binding site [chemical binding]; other site
443254004411	Q-loop/lid; other site
443254004412	ABC transporter signature motif; other site
443254004413	Walker B; other site
443254004414	D-loop; other site
443254004415	H-loop/switch region; other site
443254004416	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
443254004417	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
443254004418	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
443254004419	TM-ABC transporter signature motif; other site
443254004420	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
443254004421	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
443254004422	TM-ABC transporter signature motif; other site
443254004423	BioY family; Region: BioY; pfam02632
443254004424	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
443254004425	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
443254004426	transmembrane helices; other site
443254004427	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
443254004428	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
443254004429	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254004430	homodimer interface [polypeptide binding]; other site
443254004431	catalytic residue [active]
443254004432	ADP-glucose phosphorylase; Region: PLN02643
443254004433	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
443254004434	nucleotide binding site/active site [active]
443254004435	HIT family signature motif; other site
443254004436	catalytic residue [active]
443254004437	glycogen synthase; Provisional; Region: glgA; PRK00654
443254004438	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
443254004439	ADP-binding pocket [chemical binding]; other site
443254004440	homodimer interface [polypeptide binding]; other site
443254004441	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
443254004442	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
443254004443	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
443254004444	EDD domain protein, DegV family; Region: DegV; TIGR00762
443254004445	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
443254004446	recombination factor protein RarA; Reviewed; Region: PRK13342
443254004447	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254004448	Walker A motif; other site
443254004449	ATP binding site [chemical binding]; other site
443254004450	Walker B motif; other site
443254004451	arginine finger; other site
443254004452	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
443254004453	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis]; Region: COG1188
443254004454	RNA binding surface [nucleotide binding]; other site
443254004455	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
443254004456	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
443254004457	Walker A/P-loop; other site
443254004458	ATP binding site [chemical binding]; other site
443254004459	Q-loop/lid; other site
443254004460	ABC transporter signature motif; other site
443254004461	Walker B; other site
443254004462	D-loop; other site
443254004463	H-loop/switch region; other site
443254004464	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
443254004465	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
443254004466	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254004467	Walker A/P-loop; other site
443254004468	ATP binding site [chemical binding]; other site
443254004469	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
443254004470	Q-loop/lid; other site
443254004471	ABC transporter signature motif; other site
443254004472	Walker B; other site
443254004473	D-loop; other site
443254004474	H-loop/switch region; other site
443254004475	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
443254004476	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
443254004477	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
443254004478	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
443254004479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254004480	putative PBP binding loops; other site
443254004481	dimer interface [polypeptide binding]; other site
443254004482	ABC-ATPase subunit interface; other site
443254004483	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
443254004484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254004485	dimer interface [polypeptide binding]; other site
443254004486	conserved gate region; other site
443254004487	putative PBP binding loops; other site
443254004488	ABC-ATPase subunit interface; other site
443254004489	Starch binding domain; Region: CBM_2; smart01065
443254004490	Starch binding domain; Region: CBM_2; smart01065
443254004491	starch-binding site 2 [chemical binding]; other site
443254004492	starch-binding site 1 [chemical binding]; other site
443254004493	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
443254004494	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
443254004495	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
443254004496	putative active site [active]
443254004497	catalytic site [active]
443254004498	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
443254004499	putative ligand binding site [chemical binding]; other site
443254004500	pantoate--beta-alanine ligase; Region: panC; TIGR00018
443254004501	Pantoate-beta-alanine ligase; Region: PanC; cd00560
443254004502	active site
443254004503	ATP-binding site [chemical binding]; other site
443254004504	pantoate-binding site; other site
443254004505	HXXH motif; other site
443254004506	Cache domain; Region: Cache_1; pfam02743
443254004507	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
443254004508	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254004509	dimer interface [polypeptide binding]; other site
443254004510	putative CheW interface [polypeptide binding]; other site
443254004511	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
443254004512	MOSC domain; Region: MOSC; pfam03473
443254004513	molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168
443254004514	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
443254004515	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
443254004516	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254004517	Walker A/P-loop; other site
443254004518	ATP binding site [chemical binding]; other site
443254004519	Q-loop/lid; other site
443254004520	ABC transporter signature motif; other site
443254004521	Walker B; other site
443254004522	D-loop; other site
443254004523	H-loop/switch region; other site
443254004524	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
443254004525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254004526	dimer interface [polypeptide binding]; other site
443254004527	conserved gate region; other site
443254004528	putative PBP binding loops; other site
443254004529	ABC-ATPase subunit interface; other site
443254004530	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
443254004531	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254004532	FeS/SAM binding site; other site
443254004533	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
443254004534	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
443254004535	trimer interface [polypeptide binding]; other site
443254004536	dimer interface [polypeptide binding]; other site
443254004537	putative active site [active]
443254004538	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
443254004539	MPT binding site; other site
443254004540	trimer interface [polypeptide binding]; other site
443254004541	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
443254004542	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
443254004543	dimer interface [polypeptide binding]; other site
443254004544	putative functional site; other site
443254004545	putative MPT binding site; other site
443254004546	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
443254004547	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254004548	FeS/SAM binding site; other site
443254004549	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
443254004550	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK13951
443254004551	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
443254004552	ADP binding site [chemical binding]; other site
443254004553	magnesium binding site [ion binding]; other site
443254004554	putative shikimate binding site; other site
443254004555	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
443254004556	active site
443254004557	NAD binding site [chemical binding]; other site
443254004558	metal binding site [ion binding]; metal-binding site
443254004559	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
443254004560	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
443254004561	Tetramer interface [polypeptide binding]; other site
443254004562	active site
443254004563	FMN-binding site [chemical binding]; other site
443254004564	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
443254004565	diiron binding motif [ion binding]; other site
443254004566	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
443254004567	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
443254004568	Coenzyme A binding pocket [chemical binding]; other site
443254004569	radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115
443254004570	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254004571	FeS/SAM binding site; other site
443254004572	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
443254004573	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
443254004574	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254004575	FeS/SAM binding site; other site
443254004576	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
443254004577	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
443254004578	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254004579	FeS/SAM binding site; other site
443254004580	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
443254004581	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
443254004582	ABC-2 type transporter; Region: ABC2_membrane; cl17235
443254004583	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
443254004584	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
443254004585	Walker A/P-loop; other site
443254004586	ATP binding site [chemical binding]; other site
443254004587	Q-loop/lid; other site
443254004588	ABC transporter signature motif; other site
443254004589	Walker B; other site
443254004590	D-loop; other site
443254004591	H-loop/switch region; other site
443254004592	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
443254004593	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
443254004594	GTP/Mg2+ binding site [chemical binding]; other site
443254004595	G4 box; other site
443254004596	G5 box; other site
443254004597	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
443254004598	G1 box; other site
443254004599	Switch I region; other site
443254004600	G2 box; other site
443254004601	G3 box; other site
443254004602	Switch II region; other site
443254004603	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
443254004604	TPR repeat; Region: TPR_11; pfam13414
443254004605	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
443254004606	binding surface
443254004607	TPR motif; other site
443254004608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
443254004609	binding surface
443254004610	TPR repeat; Region: TPR_11; pfam13414
443254004611	TPR motif; other site
443254004612	Tetratricopeptide repeat; Region: TPR_12; pfam13424
443254004613	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
443254004614	Interdomain contacts; other site
443254004615	Cytokine receptor motif; other site
443254004616	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254004617	dimerization interface [polypeptide binding]; other site
443254004618	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254004619	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254004620	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254004621	dimer interface [polypeptide binding]; other site
443254004622	putative CheW interface [polypeptide binding]; other site
443254004623	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
443254004624	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
443254004625	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
443254004626	active site
443254004627	dimer interface [polypeptide binding]; other site
443254004628	effector binding site; other site
443254004629	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
443254004630	TSCPD domain; Region: TSCPD; pfam12637
443254004631	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
443254004632	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
443254004633	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
443254004634	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
443254004635	flagellin; Reviewed; Region: PRK08869
443254004636	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
443254004637	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
443254004638	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
443254004639	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
443254004640	dimerization interface [polypeptide binding]; other site
443254004641	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254004642	dimer interface [polypeptide binding]; other site
443254004643	putative CheW interface [polypeptide binding]; other site
443254004644	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
443254004645	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
443254004646	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
443254004647	Found in ATP-dependent protease La (LON); Region: LON; smart00464
443254004648	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254004649	Walker A motif; other site
443254004650	ATP binding site [chemical binding]; other site
443254004651	Walker B motif; other site
443254004652	arginine finger; other site
443254004653	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
443254004654	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
443254004655	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
443254004656	G1 box; other site
443254004657	GTP/Mg2+ binding site [chemical binding]; other site
443254004658	Switch I region; other site
443254004659	G2 box; other site
443254004660	G3 box; other site
443254004661	Switch II region; other site
443254004662	G4 box; other site
443254004663	G5 box; other site
443254004664	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
443254004665	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
443254004666	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
443254004667	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
443254004668	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
443254004669	catalytic residue [active]
443254004670	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
443254004671	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
443254004672	B12 binding site [chemical binding]; other site
443254004673	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
443254004674	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
443254004675	trmE is a tRNA modification GTPase; Region: trmE; cd04164
443254004676	G1 box; other site
443254004677	GTP/Mg2+ binding site [chemical binding]; other site
443254004678	Switch I region; other site
443254004679	G2 box; other site
443254004680	Switch II region; other site
443254004681	G3 box; other site
443254004682	G4 box; other site
443254004683	G5 box; other site
443254004684	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
443254004685	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
443254004686	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
443254004687	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
443254004688	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
443254004689	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
443254004690	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
443254004691	nudix motif; other site
443254004692	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
443254004693	active site
443254004694	HslU subunit interaction site [polypeptide binding]; other site
443254004695	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
443254004696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254004697	active site
443254004698	phosphorylation site [posttranslational modification]
443254004699	intermolecular recognition site; other site
443254004700	dimerization interface [polypeptide binding]; other site
443254004701	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
443254004702	DNA binding site [nucleotide binding]
443254004703	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
443254004704	HAMP domain; Region: HAMP; pfam00672
443254004705	dimerization interface [polypeptide binding]; other site
443254004706	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
443254004707	dimer interface [polypeptide binding]; other site
443254004708	phosphorylation site [posttranslational modification]
443254004709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254004710	ATP binding site [chemical binding]; other site
443254004711	Mg2+ binding site [ion binding]; other site
443254004712	G-X-G motif; other site
443254004713	hypothetical protein; Provisional; Region: PRK11820
443254004714	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
443254004715	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
443254004716	hypothetical protein; Provisional; Region: PRK04323
443254004717	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
443254004718	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
443254004719	catalytic site [active]
443254004720	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
443254004721	HEAT repeats; Region: HEAT_2; pfam13646
443254004722	comF family protein; Region: comF; TIGR00201
443254004723	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
443254004724	active site
443254004725	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
443254004726	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
443254004727	Uncharacterized conserved protein [Function unknown]; Region: COG1543
443254004728	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
443254004729	active site
443254004730	substrate binding site [chemical binding]; other site
443254004731	catalytic site [active]
443254004732	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
443254004733	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175
443254004734	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
443254004735	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144
443254004736	4Fe-4S binding domain; Region: Fer4; pfam00037
443254004737	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
443254004738	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
443254004739	dimer interface [polypeptide binding]; other site
443254004740	PYR/PP interface [polypeptide binding]; other site
443254004741	TPP binding site [chemical binding]; other site
443254004742	substrate binding site [chemical binding]; other site
443254004743	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
443254004744	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
443254004745	TPP-binding site [chemical binding]; other site
443254004746	putative dimer interface [polypeptide binding]; other site
443254004747	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
443254004748	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
443254004749	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
443254004750	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
443254004751	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
443254004752	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
443254004753	substrate binding pocket [chemical binding]; other site
443254004754	dimer interface [polypeptide binding]; other site
443254004755	inhibitor binding site; inhibition site
443254004756	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
443254004757	B12 binding site [chemical binding]; other site
443254004758	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
443254004759	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
443254004760	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
443254004761	putative active site [active]
443254004762	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
443254004763	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
443254004764	active site
443254004765	metal binding site [ion binding]; metal-binding site
443254004766	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
443254004767	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
443254004768	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
443254004769	Peptidase family M23; Region: Peptidase_M23; pfam01551
443254004770	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
443254004771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254004772	active site
443254004773	phosphorylation site [posttranslational modification]
443254004774	intermolecular recognition site; other site
443254004775	dimerization interface [polypeptide binding]; other site
443254004776	CheB methylesterase; Region: CheB_methylest; pfam01339
443254004777	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
443254004778	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
443254004779	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
443254004780	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
443254004781	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
443254004782	TPP-binding site [chemical binding]; other site
443254004783	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
443254004784	catalytic motif [active]
443254004785	Zn binding site [ion binding]; other site
443254004786	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
443254004787	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254004788	FeS/SAM binding site; other site
443254004789	HemN C-terminal domain; Region: HemN_C; pfam06969
443254004790	GTP-binding protein LepA; Provisional; Region: PRK05433
443254004791	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
443254004792	G1 box; other site
443254004793	putative GEF interaction site [polypeptide binding]; other site
443254004794	GTP/Mg2+ binding site [chemical binding]; other site
443254004795	Switch I region; other site
443254004796	G2 box; other site
443254004797	G3 box; other site
443254004798	Switch II region; other site
443254004799	G4 box; other site
443254004800	G5 box; other site
443254004801	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
443254004802	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
443254004803	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
443254004804	C-terminal peptidase (prc); Region: prc; TIGR00225
443254004805	PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992
443254004806	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
443254004807	Active site serine [active]
443254004808	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
443254004809	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
443254004810	active site
443254004811	Riboflavin kinase; Region: Flavokinase; pfam01687
443254004812	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
443254004813	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
443254004814	active site
443254004815	ADP/pyrophosphate binding site [chemical binding]; other site
443254004816	dimerization interface [polypeptide binding]; other site
443254004817	allosteric effector site; other site
443254004818	fructose-1,6-bisphosphate binding site; other site
443254004819	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
443254004820	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
443254004821	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
443254004822	F0F1 ATP synthase subunit C; Provisional; Region: PRK13471
443254004823	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
443254004824	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
443254004825	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
443254004826	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
443254004827	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
443254004828	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
443254004829	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
443254004830	beta subunit interaction interface [polypeptide binding]; other site
443254004831	Walker A motif; other site
443254004832	ATP binding site [chemical binding]; other site
443254004833	Walker B motif; other site
443254004834	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
443254004835	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
443254004836	core domain interface [polypeptide binding]; other site
443254004837	delta subunit interface [polypeptide binding]; other site
443254004838	epsilon subunit interface [polypeptide binding]; other site
443254004839	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
443254004840	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
443254004841	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
443254004842	alpha subunit interaction interface [polypeptide binding]; other site
443254004843	Walker A motif; other site
443254004844	ATP binding site [chemical binding]; other site
443254004845	Walker B motif; other site
443254004846	inhibitor binding site; inhibition site
443254004847	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
443254004848	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
443254004849	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
443254004850	gamma subunit interface [polypeptide binding]; other site
443254004851	epsilon subunit interface [polypeptide binding]; other site
443254004852	LBP interface [polypeptide binding]; other site
443254004853	adenylosuccinate lyase; Provisional; Region: PRK07492
443254004854	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
443254004855	tetramer interface [polypeptide binding]; other site
443254004856	active site
443254004857	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
443254004858	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
443254004859	HAMP domain; Region: HAMP; pfam00672
443254004860	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254004861	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254004862	metal binding site [ion binding]; metal-binding site
443254004863	active site
443254004864	I-site; other site
443254004865	trigger factor; Region: tig; TIGR00115
443254004866	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
443254004867	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
443254004868	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
443254004869	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
443254004870	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
443254004871	RNA binding site [nucleotide binding]; other site
443254004872	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
443254004873	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
443254004874	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
443254004875	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
443254004876	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
443254004877	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
443254004878	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
443254004879	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
443254004880	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
443254004881	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
443254004882	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
443254004883	Walker A motif; other site
443254004884	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
443254004885	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
443254004886	Archaeal ATPase; Region: Arch_ATPase; pfam01637
443254004887	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254004888	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254004889	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
443254004890	Walker A/P-loop; other site
443254004891	ATP binding site [chemical binding]; other site
443254004892	Q-loop/lid; other site
443254004893	ABC transporter signature motif; other site
443254004894	Walker B; other site
443254004895	D-loop; other site
443254004896	H-loop/switch region; other site
443254004897	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254004898	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254004899	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254004900	Walker A/P-loop; other site
443254004901	ATP binding site [chemical binding]; other site
443254004902	Q-loop/lid; other site
443254004903	ABC transporter signature motif; other site
443254004904	Walker B; other site
443254004905	D-loop; other site
443254004906	H-loop/switch region; other site
443254004907	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
443254004908	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
443254004909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254004910	dimer interface [polypeptide binding]; other site
443254004911	conserved gate region; other site
443254004912	putative PBP binding loops; other site
443254004913	ABC-ATPase subunit interface; other site
443254004914	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
443254004915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254004916	dimer interface [polypeptide binding]; other site
443254004917	conserved gate region; other site
443254004918	ABC-ATPase subunit interface; other site
443254004919	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
443254004920	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
443254004921	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
443254004922	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254004923	Zn2+ binding site [ion binding]; other site
443254004924	Mg2+ binding site [ion binding]; other site
443254004925	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
443254004926	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
443254004927	active site
443254004928	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
443254004929	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
443254004930	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
443254004931	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
443254004932	substrate-cofactor binding pocket; other site
443254004933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254004934	catalytic residue [active]
443254004935	Threonine dehydrogenase; Region: TDH; cd05281
443254004936	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
443254004937	structural Zn binding site [ion binding]; other site
443254004938	catalytic Zn binding site [ion binding]; other site
443254004939	tetramer interface [polypeptide binding]; other site
443254004940	NADP binding site [chemical binding]; other site
443254004941	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
443254004942	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
443254004943	ligand binding site [chemical binding]; other site
443254004944	flexible hinge region; other site
443254004945	Transglycosylase; Region: Transgly; pfam00912
443254004946	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
443254004947	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
443254004948	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
443254004949	Response regulator receiver domain; Region: Response_reg; pfam00072
443254004950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254004951	active site
443254004952	phosphorylation site [posttranslational modification]
443254004953	intermolecular recognition site; other site
443254004954	dimerization interface [polypeptide binding]; other site
443254004955	GAF domain; Region: GAF_3; pfam13492
443254004956	GAF domain; Region: GAF_2; pfam13185
443254004957	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
443254004958	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
443254004959	hypothetical protein; Validated; Region: PRK00110
443254004960	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
443254004961	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
443254004962	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
443254004963	lipoprotein signal peptidase; Provisional; Region: PRK14787
443254004964	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
443254004965	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
443254004966	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
443254004967	RNA binding surface [nucleotide binding]; other site
443254004968	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
443254004969	active site
443254004970	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
443254004971	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
443254004972	putative phosphate acyltransferase; Provisional; Region: PRK05331
443254004973	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
443254004974	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
443254004975	glutaminase active site [active]
443254004976	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
443254004977	dimer interface [polypeptide binding]; other site
443254004978	active site
443254004979	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
443254004980	dimer interface [polypeptide binding]; other site
443254004981	active site
443254004982	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
443254004983	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
443254004984	rRNA interaction site [nucleotide binding]; other site
443254004985	S8 interaction site; other site
443254004986	putative laminin-1 binding site; other site
443254004987	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
443254004988	homotrimer interface [polypeptide binding]; other site
443254004989	Walker A motif; other site
443254004990	GTP binding site [chemical binding]; other site
443254004991	Walker B motif; other site
443254004992	cobalamin synthase; Reviewed; Region: cobS; PRK00235
443254004993	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
443254004994	catalytic core [active]
443254004995	Histidine kinase; Region: His_kinase; pfam06580
443254004996	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
443254004997	Mg2+ binding site [ion binding]; other site
443254004998	G-X-G motif; other site
443254004999	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
443254005000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254005001	active site
443254005002	phosphorylation site [posttranslational modification]
443254005003	intermolecular recognition site; other site
443254005004	dimerization interface [polypeptide binding]; other site
443254005005	LytTr DNA-binding domain; Region: LytTR; smart00850
443254005006	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
443254005007	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
443254005008	Walker A/P-loop; other site
443254005009	ATP binding site [chemical binding]; other site
443254005010	Q-loop/lid; other site
443254005011	ABC transporter signature motif; other site
443254005012	Walker B; other site
443254005013	D-loop; other site
443254005014	H-loop/switch region; other site
443254005015	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
443254005016	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254005017	FeS/SAM binding site; other site
443254005018	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
443254005019	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
443254005020	ABC-2 type transporter; Region: ABC2_membrane; cl17235
443254005021	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
443254005022	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
443254005023	Walker A/P-loop; other site
443254005024	ATP binding site [chemical binding]; other site
443254005025	Q-loop/lid; other site
443254005026	ABC transporter signature motif; other site
443254005027	Walker B; other site
443254005028	D-loop; other site
443254005029	H-loop/switch region; other site
443254005030	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
443254005031	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
443254005032	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
443254005033	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
443254005034	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
443254005035	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
443254005036	Protein of unknown function (DUF464); Region: DUF464; pfam04327
443254005037	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
443254005038	Predicted membrane protein [Function unknown]; Region: COG3601
443254005039	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
443254005040	23S rRNA interface [nucleotide binding]; other site
443254005041	L3 interface [polypeptide binding]; other site
443254005042	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
443254005043	DNA primase; Validated; Region: dnaG; PRK05667
443254005044	CHC2 zinc finger; Region: zf-CHC2; pfam01807
443254005045	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
443254005046	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
443254005047	active site
443254005048	metal binding site [ion binding]; metal-binding site
443254005049	interdomain interaction site; other site
443254005050	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
443254005051	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
443254005052	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
443254005053	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
443254005054	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
443254005055	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
443254005056	DNA binding residues [nucleotide binding]
443254005057	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
443254005058	Part of AAA domain; Region: AAA_19; pfam13245
443254005059	Family description; Region: UvrD_C_2; pfam13538
443254005060	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
443254005061	Spore germination protein; Region: Spore_permease; cl17796
443254005062	Amidinotransferase; Region: Amidinotransf; cl12043
443254005063	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
443254005064	Zn binding site [ion binding]; other site
443254005065	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
443254005066	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
443254005067	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
443254005068	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
443254005069	catalytic loop [active]
443254005070	iron binding site [ion binding]; other site
443254005071	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
443254005072	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
443254005073	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
443254005074	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
443254005075	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
443254005076	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
443254005077	membrane protein FdrA; Validated; Region: PRK06091
443254005078	CoA binding domain; Region: CoA_binding; pfam02629
443254005079	CoA-ligase; Region: Ligase_CoA; pfam00549
443254005080	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
443254005081	Putative cyclase; Region: Cyclase; pfam04199
443254005082	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
443254005083	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
443254005084	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
443254005085	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
443254005086	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
443254005087	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
443254005088	catalytic residues [active]
443254005089	Predicted transcriptional regulators [Transcription]; Region: COG1695
443254005090	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
443254005091	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
443254005092	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
443254005093	substrate binding pocket [chemical binding]; other site
443254005094	membrane-bound complex binding site; other site
443254005095	hinge residues; other site
443254005096	PAS domain S-box; Region: sensory_box; TIGR00229
443254005097	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
443254005098	putative active site [active]
443254005099	heme pocket [chemical binding]; other site
443254005100	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254005101	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254005102	Zn2+ binding site [ion binding]; other site
443254005103	Mg2+ binding site [ion binding]; other site
443254005104	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254005105	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254005106	metal binding site [ion binding]; metal-binding site
443254005107	active site
443254005108	I-site; other site
443254005109	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
443254005110	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
443254005111	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
443254005112	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
443254005113	peptidase T; Region: peptidase-T; TIGR01882
443254005114	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
443254005115	metal binding site [ion binding]; metal-binding site
443254005116	dimer interface [polypeptide binding]; other site
443254005117	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
443254005118	Ferredoxin [Energy production and conversion]; Region: COG1146
443254005119	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
443254005120	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
443254005121	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
443254005122	dimer interface [polypeptide binding]; other site
443254005123	PYR/PP interface [polypeptide binding]; other site
443254005124	TPP binding site [chemical binding]; other site
443254005125	substrate binding site [chemical binding]; other site
443254005126	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
443254005127	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
443254005128	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
443254005129	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
443254005130	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
443254005131	16S/18S rRNA binding site [nucleotide binding]; other site
443254005132	S13e-L30e interaction site [polypeptide binding]; other site
443254005133	25S rRNA binding site [nucleotide binding]; other site
443254005134	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
443254005135	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
443254005136	active site
443254005137	phenylhydantoinase; Validated; Region: PRK08323
443254005138	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
443254005139	active site
443254005140	probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316
443254005141	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
443254005142	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
443254005143	peptidase; Reviewed; Region: PRK13004
443254005144	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
443254005145	putative metal binding site [ion binding]; other site
443254005146	putative dimer interface [polypeptide binding]; other site
443254005147	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
443254005148	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
443254005149	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
443254005150	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
443254005151	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
443254005152	ATP binding site [chemical binding]; other site
443254005153	putative Mg++ binding site [ion binding]; other site
443254005154	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
443254005155	nucleotide binding region [chemical binding]; other site
443254005156	ATP-binding site [chemical binding]; other site
443254005157	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
443254005158	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
443254005159	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
443254005160	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
443254005161	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
443254005162	heterodimer interface [polypeptide binding]; other site
443254005163	homodimer interface [polypeptide binding]; other site
443254005164	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
443254005165	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
443254005166	23S rRNA interface [nucleotide binding]; other site
443254005167	L7/L12 interface [polypeptide binding]; other site
443254005168	putative thiostrepton binding site; other site
443254005169	L25 interface [polypeptide binding]; other site
443254005170	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
443254005171	mRNA/rRNA interface [nucleotide binding]; other site
443254005172	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
443254005173	23S rRNA interface [nucleotide binding]; other site
443254005174	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
443254005175	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
443254005176	core dimer interface [polypeptide binding]; other site
443254005177	peripheral dimer interface [polypeptide binding]; other site
443254005178	L10 interface [polypeptide binding]; other site
443254005179	L11 interface [polypeptide binding]; other site
443254005180	putative EF-Tu interaction site [polypeptide binding]; other site
443254005181	putative EF-G interaction site [polypeptide binding]; other site
443254005182	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
443254005183	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
443254005184	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
443254005185	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
443254005186	RPB11 interaction site [polypeptide binding]; other site
443254005187	RPB12 interaction site [polypeptide binding]; other site
443254005188	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
443254005189	RPB10 interaction site [polypeptide binding]; other site
443254005190	RPB1 interaction site [polypeptide binding]; other site
443254005191	RPB11 interaction site [polypeptide binding]; other site
443254005192	RPB3 interaction site [polypeptide binding]; other site
443254005193	RPB12 interaction site [polypeptide binding]; other site
443254005194	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
443254005195	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
443254005196	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
443254005197	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
443254005198	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
443254005199	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
443254005200	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
443254005201	G-loop; other site
443254005202	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
443254005203	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
443254005204	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
443254005205	DNA binding site [nucleotide binding]
443254005206	clamp; other site
443254005207	Rpb1 - Rpb2 interaction site [polypeptide binding]; other site
443254005208	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
443254005209	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
443254005210	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
443254005211	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
443254005212	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
443254005213	probable molybdenum cofactor biosynthesis protein A, archaeal; Region: moaA_archaeal; TIGR02668
443254005214	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254005215	FeS/SAM binding site; other site
443254005216	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
443254005217	GAF domain; Region: GAF; cl17456
443254005218	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
443254005219	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
443254005220	dimer interface [polypeptide binding]; other site
443254005221	phosphorylation site [posttranslational modification]
443254005222	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254005223	ATP binding site [chemical binding]; other site
443254005224	Mg2+ binding site [ion binding]; other site
443254005225	G-X-G motif; other site
443254005226	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
443254005227	putative active site [active]
443254005228	putative CoA binding site [chemical binding]; other site
443254005229	nudix motif; other site
443254005230	metal binding site [ion binding]; metal-binding site
443254005231	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
443254005232	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
443254005233	EamA-like transporter family; Region: EamA; pfam00892
443254005234	hypothetical protein; Provisional; Region: PRK08328
443254005235	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
443254005236	ATP binding site [chemical binding]; other site
443254005237	substrate interface [chemical binding]; other site
443254005238	S-layer homology domain; Region: SLH; pfam00395
443254005239	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
443254005240	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
443254005241	active site
443254005242	HIGH motif; other site
443254005243	dimer interface [polypeptide binding]; other site
443254005244	KMSKS motif; other site
443254005245	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
443254005246	RNA binding surface [nucleotide binding]; other site
443254005247	Preprotein translocase SecG subunit; Region: SecG; pfam03840
443254005248	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
443254005249	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
443254005250	RNA binding site [nucleotide binding]; other site
443254005251	Ribosomal protein L31; Region: Ribosomal_L31; pfam01197
443254005252	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
443254005253	active site
443254005254	metal binding site [ion binding]; metal-binding site
443254005255	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
443254005256	binding surface
443254005257	TPR motif; other site
443254005258	TPR repeat; Region: TPR_11; pfam13414
443254005259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
443254005260	binding surface
443254005261	TPR motif; other site
443254005262	Tetratricopeptide repeat; Region: TPR_16; pfam13432
443254005263	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
443254005264	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
443254005265	RNA binding surface [nucleotide binding]; other site
443254005266	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
443254005267	active site
443254005268	uracil binding [chemical binding]; other site
443254005269	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
443254005270	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254005271	Walker A/P-loop; other site
443254005272	ATP binding site [chemical binding]; other site
443254005273	Q-loop/lid; other site
443254005274	ABC transporter signature motif; other site
443254005275	Walker B; other site
443254005276	D-loop; other site
443254005277	H-loop/switch region; other site
443254005278	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
443254005279	SmpB-tmRNA interface; other site
443254005280	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
443254005281	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
443254005282	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
443254005283	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
443254005284	DNA repair protein RadA; Provisional; Region: PRK11823
443254005285	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
443254005286	Walker A motif; other site
443254005287	ATP binding site [chemical binding]; other site
443254005288	Walker B motif; other site
443254005289	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
443254005290	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
443254005291	Clp amino terminal domain; Region: Clp_N; pfam02861
443254005292	Clp amino terminal domain; Region: Clp_N; pfam02861
443254005293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254005294	Walker A motif; other site
443254005295	ATP binding site [chemical binding]; other site
443254005296	Walker B motif; other site
443254005297	arginine finger; other site
443254005298	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254005299	Walker A motif; other site
443254005300	ATP binding site [chemical binding]; other site
443254005301	Walker B motif; other site
443254005302	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
443254005303	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
443254005304	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
443254005305	transmembrane helices; other site
443254005306	RNase III inhibitor; Provisional; Region: PRK00431
443254005307	ADP-ribose binding site [chemical binding]; other site
443254005308	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
443254005309	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
443254005310	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
443254005311	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
443254005312	DNA polymerase III PolC; Validated; Region: polC; PRK00448
443254005313	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
443254005314	generic binding surface I; other site
443254005315	generic binding surface II; other site
443254005316	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
443254005317	active site
443254005318	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
443254005319	active site
443254005320	catalytic site [active]
443254005321	substrate binding site [chemical binding]; other site
443254005322	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
443254005323	putative PHP Thumb interface [polypeptide binding]; other site
443254005324	Response regulator receiver domain; Region: Response_reg; pfam00072
443254005325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254005326	active site
443254005327	phosphorylation site [posttranslational modification]
443254005328	intermolecular recognition site; other site
443254005329	dimerization interface [polypeptide binding]; other site
443254005330	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
443254005331	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
443254005332	active site
443254005333	metal binding site [ion binding]; metal-binding site
443254005334	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
443254005335	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
443254005336	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
443254005337	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
443254005338	active site
443254005339	Rubredoxin [Energy production and conversion]; Region: COG1773
443254005340	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
443254005341	iron binding site [ion binding]; other site
443254005342	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254005343	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254005344	dimer interface [polypeptide binding]; other site
443254005345	putative CheW interface [polypeptide binding]; other site
443254005346	glutamine synthetase, type I; Region: GlnA; TIGR00653
443254005347	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
443254005348	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
443254005349	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
443254005350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254005351	S-adenosylmethionine binding site [chemical binding]; other site
443254005352	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
443254005353	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
443254005354	Walker A/P-loop; other site
443254005355	ATP binding site [chemical binding]; other site
443254005356	Q-loop/lid; other site
443254005357	ABC transporter signature motif; other site
443254005358	Walker B; other site
443254005359	D-loop; other site
443254005360	H-loop/switch region; other site
443254005361	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
443254005362	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
443254005363	Walker A/P-loop; other site
443254005364	ATP binding site [chemical binding]; other site
443254005365	Q-loop/lid; other site
443254005366	ABC transporter signature motif; other site
443254005367	Walker B; other site
443254005368	D-loop; other site
443254005369	H-loop/switch region; other site
443254005370	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
443254005371	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
443254005372	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
443254005373	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
443254005374	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
443254005375	23S rRNA binding site [nucleotide binding]; other site
443254005376	L21 binding site [polypeptide binding]; other site
443254005377	L13 binding site [polypeptide binding]; other site
443254005378	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
443254005379	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
443254005380	active site
443254005381	HIGH motif; other site
443254005382	nucleotide binding site [chemical binding]; other site
443254005383	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
443254005384	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
443254005385	active site
443254005386	KMSKS motif; other site
443254005387	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
443254005388	tRNA binding surface [nucleotide binding]; other site
443254005389	anticodon binding site; other site
443254005390	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
443254005391	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
443254005392	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
443254005393	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
443254005394	RuvA N terminal domain; Region: RuvA_N; pfam01330
443254005395	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14357
443254005396	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
443254005397	Substrate binding site; other site
443254005398	Mg++ binding site; other site
443254005399	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
443254005400	active site
443254005401	substrate binding site [chemical binding]; other site
443254005402	CoA binding site [chemical binding]; other site
443254005403	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
443254005404	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
443254005405	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
443254005406	active site
443254005407	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
443254005408	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
443254005409	5S rRNA interface [nucleotide binding]; other site
443254005410	CTC domain interface [polypeptide binding]; other site
443254005411	L16 interface [polypeptide binding]; other site
443254005412	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
443254005413	putative active site [active]
443254005414	catalytic residue [active]
443254005415	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
443254005416	anti sigma factor interaction site; other site
443254005417	regulatory phosphorylation site [posttranslational modification]; other site
443254005418	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
443254005419	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
443254005420	6-phosphofructokinase; Provisional; Region: PRK03202
443254005421	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
443254005422	active site
443254005423	ADP/pyrophosphate binding site [chemical binding]; other site
443254005424	dimerization interface [polypeptide binding]; other site
443254005425	allosteric effector site; other site
443254005426	fructose-1,6-bisphosphate binding site; other site
443254005427	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
443254005428	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
443254005429	putative active site [active]
443254005430	heme pocket [chemical binding]; other site
443254005431	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
443254005432	putative active site [active]
443254005433	heme pocket [chemical binding]; other site
443254005434	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254005435	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254005436	metal binding site [ion binding]; metal-binding site
443254005437	active site
443254005438	I-site; other site
443254005439	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
443254005440	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
443254005441	ABC transporter; Region: ABC_tran_2; pfam12848
443254005442	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
443254005443	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
443254005444	homodimer interface [polypeptide binding]; other site
443254005445	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
443254005446	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
443254005447	active site
443254005448	homodimer interface [polypeptide binding]; other site
443254005449	catalytic site [active]
443254005450	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
443254005451	anti sigma factor interaction site; other site
443254005452	regulatory phosphorylation site [posttranslational modification]; other site
443254005453	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
443254005454	catalytic residues [active]
443254005455	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
443254005456	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
443254005457	active site
443254005458	Predicted transcriptional regulators [Transcription]; Region: COG1695
443254005459	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
443254005460	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254005461	dimerization interface [polypeptide binding]; other site
443254005462	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254005463	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254005464	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254005465	dimer interface [polypeptide binding]; other site
443254005466	putative CheW interface [polypeptide binding]; other site
443254005467	Global regulator protein family; Region: CsrA; pfam02599
443254005468	flagellar assembly protein FliW; Provisional; Region: PRK13285
443254005469	flagellar assembly protein FliW; Provisional; Region: PRK13285
443254005470	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
443254005471	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
443254005472	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
443254005473	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
443254005474	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
443254005475	FlgN protein; Region: FlgN; pfam05130
443254005476	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
443254005477	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
443254005478	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
443254005479	putative tRNA-binding site [nucleotide binding]; other site
443254005480	B3/4 domain; Region: B3_4; pfam03483
443254005481	tRNA synthetase B5 domain; Region: B5; smart00874
443254005482	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
443254005483	dimer interface [polypeptide binding]; other site
443254005484	motif 1; other site
443254005485	motif 3; other site
443254005486	motif 2; other site
443254005487	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
443254005488	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
443254005489	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
443254005490	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
443254005491	dimer interface [polypeptide binding]; other site
443254005492	motif 1; other site
443254005493	active site
443254005494	motif 2; other site
443254005495	motif 3; other site
443254005496	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
443254005497	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
443254005498	active site
443254005499	intersubunit interactions; other site
443254005500	catalytic residue [active]
443254005501	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
443254005502	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
443254005503	homodimer interface [polypeptide binding]; other site
443254005504	oligonucleotide binding site [chemical binding]; other site
443254005505	Esterase/lipase [General function prediction only]; Region: COG1647
443254005506	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
443254005507	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
443254005508	flagellin; Reviewed; Region: PRK08869
443254005509	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
443254005510	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
443254005511	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
443254005512	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
443254005513	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
443254005514	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
443254005515	Protein export membrane protein; Region: SecD_SecF; pfam02355
443254005516	protein-export membrane protein SecD; Region: secD; TIGR01129
443254005517	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
443254005518	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
443254005519	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
443254005520	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
443254005521	shikimate kinase; Reviewed; Region: aroK; PRK00131
443254005522	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
443254005523	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
443254005524	ATP cone domain; Region: ATP-cone; pfam03477
443254005525	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
443254005526	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
443254005527	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
443254005528	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
443254005529	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
443254005530	dimer interface [polypeptide binding]; other site
443254005531	putative anticodon binding site; other site
443254005532	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
443254005533	motif 1; other site
443254005534	active site
443254005535	motif 2; other site
443254005536	motif 3; other site
443254005537	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
443254005538	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
443254005539	PilZ domain; Region: PilZ; pfam07238
443254005540	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
443254005541	GAF domain; Region: GAF_3; pfam13492
443254005542	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
443254005543	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254005544	Predicted membrane protein [Function unknown]; Region: COG4267
443254005545	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
443254005546	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
443254005547	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
443254005548	Predicted amidohydrolase [General function prediction only]; Region: COG0388
443254005549	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
443254005550	active site
443254005551	catalytic triad [active]
443254005552	dimer interface [polypeptide binding]; other site
443254005553	TM1410 hypothetical-related protein; Region: DUF297; cl00997
443254005554	NTPase; Region: NTPase_1; cl17478
443254005555	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
443254005556	Bacitracin resistance protein BacA; Region: BacA; pfam02673
443254005557	Domain of unknown function (DUF368); Region: DUF368; pfam04018
443254005558	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
443254005559	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
443254005560	Cache domain; Region: Cache_1; pfam02743
443254005561	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254005562	dimerization interface [polypeptide binding]; other site
443254005563	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254005564	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254005565	dimer interface [polypeptide binding]; other site
443254005566	putative CheW interface [polypeptide binding]; other site
443254005567	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
443254005568	Dehydroquinase class II; Region: DHquinase_II; pfam01220
443254005569	trimer interface [polypeptide binding]; other site
443254005570	active site
443254005571	dimer interface [polypeptide binding]; other site
443254005572	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
443254005573	DEAD-like helicases superfamily; Region: DEXDc; smart00487
443254005574	ATP binding site [chemical binding]; other site
443254005575	Mg++ binding site [ion binding]; other site
443254005576	motif III; other site
443254005577	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
443254005578	nucleotide binding region [chemical binding]; other site
443254005579	ATP-binding site [chemical binding]; other site
443254005580	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
443254005581	RNA binding site [nucleotide binding]; other site
443254005582	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
443254005583	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
443254005584	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
443254005585	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
443254005586	Peptidase family U32; Region: Peptidase_U32; pfam01136
443254005587	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
443254005588	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
443254005589	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
443254005590	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
443254005591	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
443254005592	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
443254005593	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
443254005594	Peptidase family M23; Region: Peptidase_M23; pfam01551
443254005595	3D domain; Region: 3D; cl01439
443254005596	Predicted transcriptional regulator [Transcription]; Region: COG1959
443254005597	Transcriptional regulator; Region: Rrf2; cl17282
443254005598	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
443254005599	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
443254005600	Ligand Binding Site [chemical binding]; other site
443254005601	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
443254005602	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
443254005603	active site
443254005604	(T/H)XGH motif; other site
443254005605	elongation factor Ts; Reviewed; Region: tsf; PRK12332
443254005606	UBA/TS-N domain; Region: UBA; pfam00627
443254005607	Elongation factor TS; Region: EF_TS; pfam00889
443254005608	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
443254005609	putative nucleotide binding site [chemical binding]; other site
443254005610	uridine monophosphate binding site [chemical binding]; other site
443254005611	homohexameric interface [polypeptide binding]; other site
443254005612	enolase; Provisional; Region: eno; PRK00077
443254005613	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
443254005614	dimer interface [polypeptide binding]; other site
443254005615	metal binding site [ion binding]; metal-binding site
443254005616	substrate binding pocket [chemical binding]; other site
443254005617	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
443254005618	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
443254005619	oligomer interface [polypeptide binding]; other site
443254005620	active site
443254005621	metal binding site [ion binding]; metal-binding site
443254005622	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
443254005623	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
443254005624	oligomer interface [polypeptide binding]; other site
443254005625	active site
443254005626	metal binding site [ion binding]; metal-binding site
443254005627	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
443254005628	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
443254005629	oligomer interface [polypeptide binding]; other site
443254005630	active site
443254005631	metal binding site [ion binding]; metal-binding site
443254005632	septum formation inhibitor; Provisional; Region: minC; PRK13992
443254005633	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
443254005634	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
443254005635	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
443254005636	B12 binding site [chemical binding]; other site
443254005637	cobalt ligand [ion binding]; other site
443254005638	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
443254005639	Walker A; other site
443254005640	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
443254005641	G4 box; other site
443254005642	G5 box; other site
443254005643	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
443254005644	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
443254005645	dimer interface [polypeptide binding]; other site
443254005646	substrate binding site [chemical binding]; other site
443254005647	metal binding site [ion binding]; metal-binding site
443254005648	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
443254005649	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
443254005650	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
443254005651	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
443254005652	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
443254005653	carboxyltransferase (CT) interaction site; other site
443254005654	biotinylation site [posttranslational modification]; other site
443254005655	hypothetical protein; Provisional; Region: PRK04860
443254005656	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
443254005657	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
443254005658	putative NAD(P) binding site [chemical binding]; other site
443254005659	putative active site [active]
443254005660	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
443254005661	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
443254005662	active site
443254005663	HIGH motif; other site
443254005664	nucleotide binding site [chemical binding]; other site
443254005665	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
443254005666	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
443254005667	active site
443254005668	KMSKS motif; other site
443254005669	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
443254005670	tRNA binding surface [nucleotide binding]; other site
443254005671	anticodon binding site; other site
443254005672	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
443254005673	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
443254005674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254005675	active site
443254005676	phosphorylation site [posttranslational modification]
443254005677	intermolecular recognition site; other site
443254005678	dimerization interface [polypeptide binding]; other site
443254005679	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
443254005680	GAF domain; Region: GAF_3; pfam13492
443254005681	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
443254005682	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
443254005683	putative active site [active]
443254005684	heme pocket [chemical binding]; other site
443254005685	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
443254005686	dimer interface [polypeptide binding]; other site
443254005687	phosphorylation site [posttranslational modification]
443254005688	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254005689	ATP binding site [chemical binding]; other site
443254005690	Mg2+ binding site [ion binding]; other site
443254005691	G-X-G motif; other site
443254005692	Uncharacterized conserved protein [Function unknown]; Region: COG1284
443254005693	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
443254005694	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
443254005695	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
443254005696	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
443254005697	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
443254005698	Ligand Binding Site [chemical binding]; other site
443254005699	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
443254005700	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
443254005701	putative acyl-acceptor binding pocket; other site
443254005702	Bifunctional nuclease; Region: DNase-RNase; pfam02577
443254005703	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
443254005704	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
443254005705	substrate binding pocket [chemical binding]; other site
443254005706	chain length determination region; other site
443254005707	substrate-Mg2+ binding site; other site
443254005708	catalytic residues [active]
443254005709	aspartate-rich region 1; other site
443254005710	active site lid residues [active]
443254005711	aspartate-rich region 2; other site
443254005712	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
443254005713	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
443254005714	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
443254005715	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
443254005716	active site
443254005717	glutamine synthetase, type I; Region: GlnA; TIGR00653
443254005718	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
443254005719	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
443254005720	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
443254005721	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
443254005722	substrate binding site; other site
443254005723	metal-binding site
443254005724	Oligomer interface; other site
443254005725	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
443254005726	putative CoA binding site [chemical binding]; other site
443254005727	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
443254005728	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
443254005729	active site
443254005730	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
443254005731	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
443254005732	B12 binding site [chemical binding]; other site
443254005733	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254005734	FeS/SAM binding site; other site
443254005735	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
443254005736	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
443254005737	putative ligand binding site [chemical binding]; other site
443254005738	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
443254005739	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
443254005740	TM-ABC transporter signature motif; other site
443254005741	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
443254005742	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
443254005743	TM-ABC transporter signature motif; other site
443254005744	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
443254005745	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
443254005746	Walker A/P-loop; other site
443254005747	ATP binding site [chemical binding]; other site
443254005748	Q-loop/lid; other site
443254005749	ABC transporter signature motif; other site
443254005750	Walker B; other site
443254005751	D-loop; other site
443254005752	H-loop/switch region; other site
443254005753	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
443254005754	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
443254005755	Walker A/P-loop; other site
443254005756	ATP binding site [chemical binding]; other site
443254005757	Q-loop/lid; other site
443254005758	ABC transporter signature motif; other site
443254005759	Walker B; other site
443254005760	D-loop; other site
443254005761	H-loop/switch region; other site
443254005762	QueT transporter; Region: QueT; pfam06177
443254005763	replicative DNA helicase; Region: DnaB; TIGR00665
443254005764	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
443254005765	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
443254005766	Walker A motif; other site
443254005767	ATP binding site [chemical binding]; other site
443254005768	Walker B motif; other site
443254005769	DNA binding loops [nucleotide binding]
443254005770	ribonuclease R; Region: RNase_R; TIGR02063
443254005771	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
443254005772	RNB domain; Region: RNB; pfam00773
443254005773	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
443254005774	RNA binding site [nucleotide binding]; other site
443254005775	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
443254005776	Ferritin-like domain; Region: Ferritin; pfam00210
443254005777	ferroxidase diiron center [ion binding]; other site
443254005778	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
443254005779	catalytic loop [active]
443254005780	iron binding site [ion binding]; other site
443254005781	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
443254005782	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
443254005783	4Fe-4S binding domain; Region: Fer4; pfam00037
443254005784	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
443254005785	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
443254005786	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
443254005787	dimer interface [polypeptide binding]; other site
443254005788	[2Fe-2S] cluster binding site [ion binding]; other site
443254005789	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
443254005790	SLBB domain; Region: SLBB; pfam10531
443254005791	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
443254005792	4Fe-4S binding domain; Region: Fer4; pfam00037
443254005793	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
443254005794	4Fe-4S binding domain; Region: Fer4; pfam00037
443254005795	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
443254005796	dimer interface [polypeptide binding]; other site
443254005797	[2Fe-2S] cluster binding site [ion binding]; other site
443254005798	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
443254005799	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
443254005800	putative dimer interface [polypeptide binding]; other site
443254005801	[2Fe-2S] cluster binding site [ion binding]; other site
443254005802	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
443254005803	oligomerisation interface [polypeptide binding]; other site
443254005804	mobile loop; other site
443254005805	roof hairpin; other site
443254005806	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
443254005807	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
443254005808	ring oligomerisation interface [polypeptide binding]; other site
443254005809	ATP/Mg binding site [chemical binding]; other site
443254005810	stacking interactions; other site
443254005811	hinge regions; other site
443254005812	hypothetical protein; Provisional; Region: PRK07205
443254005813	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
443254005814	active site
443254005815	metal binding site [ion binding]; metal-binding site
443254005816	Predicted membrane protein [Function unknown]; Region: COG1288
443254005817	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
443254005818	V-type ATP synthase subunit I; Validated; Region: PRK05771
443254005819	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
443254005820	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
443254005821	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
443254005822	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
443254005823	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
443254005824	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
443254005825	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
443254005826	Flagellar protein (FlbD); Region: FlbD; pfam06289
443254005827	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
443254005828	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
443254005829	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
443254005830	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
443254005831	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
443254005832	ligand binding site [chemical binding]; other site
443254005833	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
443254005834	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
443254005835	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
443254005836	flagellar motor switch protein; Validated; Region: PRK08119
443254005837	CheC-like family; Region: CheC; pfam04509
443254005838	CheC-like family; Region: CheC; pfam04509
443254005839	flagellar motor switch protein FliN; Region: fliN; TIGR02480
443254005840	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
443254005841	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254005842	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254005843	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254005844	Walker A/P-loop; other site
443254005845	ATP binding site [chemical binding]; other site
443254005846	Q-loop/lid; other site
443254005847	ABC transporter signature motif; other site
443254005848	Walker B; other site
443254005849	D-loop; other site
443254005850	H-loop/switch region; other site
443254005851	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
443254005852	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
443254005853	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
443254005854	Walker A/P-loop; other site
443254005855	ATP binding site [chemical binding]; other site
443254005856	Q-loop/lid; other site
443254005857	ABC transporter signature motif; other site
443254005858	Walker B; other site
443254005859	D-loop; other site
443254005860	H-loop/switch region; other site
443254005861	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254005862	S-adenosylmethionine binding site [chemical binding]; other site
443254005863	Major Facilitator Superfamily; Region: MFS_1; pfam07690
443254005864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
443254005865	putative substrate translocation pore; other site
443254005866	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
443254005867	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
443254005868	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
443254005869	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
443254005870	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
443254005871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254005872	dimer interface [polypeptide binding]; other site
443254005873	conserved gate region; other site
443254005874	putative PBP binding loops; other site
443254005875	ABC-ATPase subunit interface; other site
443254005876	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
443254005877	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
443254005878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254005879	dimer interface [polypeptide binding]; other site
443254005880	conserved gate region; other site
443254005881	putative PBP binding loops; other site
443254005882	ABC-ATPase subunit interface; other site
443254005883	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
443254005884	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
443254005885	Walker A/P-loop; other site
443254005886	ATP binding site [chemical binding]; other site
443254005887	Q-loop/lid; other site
443254005888	ABC transporter signature motif; other site
443254005889	Walker B; other site
443254005890	D-loop; other site
443254005891	H-loop/switch region; other site
443254005892	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
443254005893	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
443254005894	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
443254005895	Walker A/P-loop; other site
443254005896	ATP binding site [chemical binding]; other site
443254005897	Q-loop/lid; other site
443254005898	ABC transporter signature motif; other site
443254005899	Walker B; other site
443254005900	D-loop; other site
443254005901	H-loop/switch region; other site
443254005902	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
443254005903	Cache domain; Region: Cache_1; pfam02743
443254005904	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254005905	dimerization interface [polypeptide binding]; other site
443254005906	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254005907	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254005908	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254005909	dimer interface [polypeptide binding]; other site
443254005910	putative CheW interface [polypeptide binding]; other site
443254005911	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
443254005912	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254005913	dimerization interface [polypeptide binding]; other site
443254005914	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254005915	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254005916	dimer interface [polypeptide binding]; other site
443254005917	putative CheW interface [polypeptide binding]; other site
443254005918	Cache domain; Region: Cache_1; pfam02743
443254005919	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
443254005920	dimerization interface [polypeptide binding]; other site
443254005921	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254005922	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
443254005923	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254005924	dimer interface [polypeptide binding]; other site
443254005925	putative CheW interface [polypeptide binding]; other site
443254005926	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
443254005927	intersubunit interface [polypeptide binding]; other site
443254005928	active site
443254005929	Zn2+ binding site [ion binding]; other site
443254005930	aspartate aminotransferase; Provisional; Region: PRK07568
443254005931	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
443254005932	pyridoxal 5'-phosphate binding site [chemical binding]; other site
443254005933	homodimer interface [polypeptide binding]; other site
443254005934	catalytic residue [active]
443254005935	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
443254005936	RNA/DNA hybrid binding site [nucleotide binding]; other site
443254005937	active site
443254005938	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
443254005939	homodimer interface [polypeptide binding]; other site
443254005940	metal binding site [ion binding]; metal-binding site
443254005941	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
443254005942	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
443254005943	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
443254005944	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
443254005945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254005946	S-adenosylmethionine binding site [chemical binding]; other site
443254005947	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
443254005948	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
443254005949	substrate binding pocket [chemical binding]; other site
443254005950	membrane-bound complex binding site; other site
443254005951	hinge residues; other site
443254005952	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
443254005953	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
443254005954	substrate binding pocket [chemical binding]; other site
443254005955	membrane-bound complex binding site; other site
443254005956	hinge residues; other site
443254005957	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
443254005958	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
443254005959	dimer interface [polypeptide binding]; other site
443254005960	phosphorylation site [posttranslational modification]
443254005961	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254005962	ATP binding site [chemical binding]; other site
443254005963	Mg2+ binding site [ion binding]; other site
443254005964	G-X-G motif; other site
443254005965	Response regulator receiver domain; Region: Response_reg; pfam00072
443254005966	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254005967	active site
443254005968	phosphorylation site [posttranslational modification]
443254005969	intermolecular recognition site; other site
443254005970	Low molecular weight phosphatase family; Region: LMWPc; cl00105
443254005971	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254005972	Zn2+ binding site [ion binding]; other site
443254005973	Mg2+ binding site [ion binding]; other site
443254005974	prolyl-tRNA synthetase; Provisional; Region: PRK09194
443254005975	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
443254005976	dimer interface [polypeptide binding]; other site
443254005977	motif 1; other site
443254005978	active site
443254005979	motif 2; other site
443254005980	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
443254005981	putative deacylase active site [active]
443254005982	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
443254005983	active site
443254005984	motif 3; other site
443254005985	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
443254005986	anticodon binding site; other site
443254005987	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
443254005988	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
443254005989	active site
443254005990	HIGH motif; other site
443254005991	KMSKS motif; other site
443254005992	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
443254005993	tRNA binding surface [nucleotide binding]; other site
443254005994	anticodon binding site; other site
443254005995	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
443254005996	dimer interface [polypeptide binding]; other site
443254005997	putative tRNA-binding site [nucleotide binding]; other site
443254005998	DNA gyrase subunit A; Validated; Region: PRK05560
443254005999	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
443254006000	CAP-like domain; other site
443254006001	active site
443254006002	primary dimer interface [polypeptide binding]; other site
443254006003	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
443254006004	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
443254006005	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
443254006006	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
443254006007	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
443254006008	Archease protein family (MTH1598/TM1083); Region: Archease; cl00606
443254006009	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
443254006010	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
443254006011	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
443254006012	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
443254006013	active site
443254006014	Zn binding site [ion binding]; other site
443254006015	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
443254006016	active site
443254006017	NAD binding site [chemical binding]; other site
443254006018	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
443254006019	Helix-hairpin-helix motif; Region: HHH; pfam00633
443254006020	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
443254006021	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
443254006022	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
443254006023	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
443254006024	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
443254006025	Protein of unknown function (DUF342); Region: DUF342; pfam03961
443254006026	Peptidase C1-like family; Region: Peptidase_C1_2; cl17447
443254006027	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
443254006028	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
443254006029	FOG: CBS domain [General function prediction only]; Region: COG0517
443254006030	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
443254006031	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
443254006032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
443254006033	ATP binding site [chemical binding]; other site
443254006034	Mg2+ binding site [ion binding]; other site
443254006035	G-X-G motif; other site
443254006036	DRTGG domain; Region: DRTGG; pfam07085
443254006037	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
443254006038	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
443254006039	active site
443254006040	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
443254006041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254006042	ATP binding site [chemical binding]; other site
443254006043	Mg2+ binding site [ion binding]; other site
443254006044	G-X-G motif; other site
443254006045	Surface antigen; Region: Bac_surface_Ag; pfam01103
443254006046	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
443254006047	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
443254006048	active site
443254006049	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
443254006050	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
443254006051	diaminopimelate decarboxylase; Region: lysA; TIGR01048
443254006052	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
443254006053	active site
443254006054	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
443254006055	substrate binding site [chemical binding]; other site
443254006056	catalytic residues [active]
443254006057	dimer interface [polypeptide binding]; other site
443254006058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
443254006059	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
443254006060	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
443254006061	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
443254006062	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
443254006063	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
443254006064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254006065	dimer interface [polypeptide binding]; other site
443254006066	conserved gate region; other site
443254006067	ABC-ATPase subunit interface; other site
443254006068	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
443254006069	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254006070	dimer interface [polypeptide binding]; other site
443254006071	conserved gate region; other site
443254006072	putative PBP binding loops; other site
443254006073	ABC-ATPase subunit interface; other site
443254006074	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
443254006075	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
443254006076	Walker A/P-loop; other site
443254006077	ATP binding site [chemical binding]; other site
443254006078	Q-loop/lid; other site
443254006079	ABC transporter signature motif; other site
443254006080	Walker B; other site
443254006081	D-loop; other site
443254006082	H-loop/switch region; other site
443254006083	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
443254006084	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
443254006085	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
443254006086	Walker A/P-loop; other site
443254006087	ATP binding site [chemical binding]; other site
443254006088	Q-loop/lid; other site
443254006089	ABC transporter signature motif; other site
443254006090	Walker B; other site
443254006091	D-loop; other site
443254006092	H-loop/switch region; other site
443254006093	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
443254006094	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
443254006095	isocitrate dehydrogenase; Validated; Region: PRK06451
443254006096	gamma-glutamyl kinase; Provisional; Region: PRK05429
443254006097	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
443254006098	nucleotide binding site [chemical binding]; other site
443254006099	homotetrameric interface [polypeptide binding]; other site
443254006100	putative phosphate binding site [ion binding]; other site
443254006101	putative allosteric binding site; other site
443254006102	PUA domain; Region: PUA; pfam01472
443254006103	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
443254006104	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
443254006105	putative catalytic cysteine [active]
443254006106	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
443254006107	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
443254006108	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
443254006109	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
443254006110	substrate binding site [chemical binding]; other site
443254006111	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
443254006112	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
443254006113	substrate binding site [chemical binding]; other site
443254006114	ligand binding site [chemical binding]; other site
443254006115	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
443254006116	dimer interface [polypeptide binding]; other site
443254006117	Citrate synthase; Region: Citrate_synt; pfam00285
443254006118	active site
443254006119	coenzyme A binding site [chemical binding]; other site
443254006120	citrylCoA binding site [chemical binding]; other site
443254006121	oxalacetate/citrate binding site [chemical binding]; other site
443254006122	catalytic triad [active]
443254006123	Uncharacterized conserved protein [Function unknown]; Region: COG5276
443254006124	Uncharacterized conserved protein [Function unknown]; Region: COG5276
443254006125	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254006126	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
443254006127	Uncharacterized conserved protein [Function unknown]; Region: COG5276
443254006128	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
443254006129	Divergent AAA domain; Region: AAA_4; pfam04326
443254006130	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
443254006131	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254006132	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
443254006133	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
443254006134	Walker A/P-loop; other site
443254006135	ATP binding site [chemical binding]; other site
443254006136	Q-loop/lid; other site
443254006137	ABC transporter signature motif; other site
443254006138	Walker B; other site
443254006139	D-loop; other site
443254006140	H-loop/switch region; other site
443254006141	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
443254006142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254006143	dimer interface [polypeptide binding]; other site
443254006144	conserved gate region; other site
443254006145	putative PBP binding loops; other site
443254006146	ABC-ATPase subunit interface; other site
443254006147	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
443254006148	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
443254006149	substrate binding pocket [chemical binding]; other site
443254006150	membrane-bound complex binding site; other site
443254006151	hinge residues; other site
443254006152	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
443254006153	metal binding site 2 [ion binding]; metal-binding site
443254006154	putative DNA binding helix; other site
443254006155	metal binding site 1 [ion binding]; metal-binding site
443254006156	dimer interface [polypeptide binding]; other site
443254006157	structural Zn2+ binding site [ion binding]; other site
443254006158	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
443254006159	binding surface
443254006160	TPR motif; other site
443254006161	Tetratricopeptide repeat; Region: TPR_12; pfam13424
443254006162	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
443254006163	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
443254006164	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
443254006165	protein binding site [polypeptide binding]; other site
443254006166	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
443254006167	protein binding site [polypeptide binding]; other site
443254006168	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
443254006169	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254006170	dimer interface [polypeptide binding]; other site
443254006171	conserved gate region; other site
443254006172	putative PBP binding loops; other site
443254006173	ABC-ATPase subunit interface; other site
443254006174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
443254006175	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
443254006176	Walker A/P-loop; other site
443254006177	ATP binding site [chemical binding]; other site
443254006178	Q-loop/lid; other site
443254006179	ABC transporter signature motif; other site
443254006180	Walker B; other site
443254006181	D-loop; other site
443254006182	H-loop/switch region; other site
443254006183	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
443254006184	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
443254006185	GIY-YIG motif/motif A; other site
443254006186	active site
443254006187	catalytic site [active]
443254006188	putative DNA binding site [nucleotide binding]; other site
443254006189	metal binding site [ion binding]; metal-binding site
443254006190	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
443254006191	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
443254006192	DNA binding site [nucleotide binding]
443254006193	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254006194	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254006195	metal binding site [ion binding]; metal-binding site
443254006196	active site
443254006197	I-site; other site
443254006198	Protein of unknown function (DUF501); Region: DUF501; pfam04417
443254006199	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
443254006200	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254006201	S-adenosylmethionine binding site [chemical binding]; other site
443254006202	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
443254006203	active site
443254006204	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
443254006205	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
443254006206	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
443254006207	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
443254006208	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
443254006209	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
443254006210	catalytic triad [active]
443254006211	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
443254006212	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
443254006213	S-adenosylmethionine binding site [chemical binding]; other site
443254006214	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
443254006215	carbohydrate binding site [chemical binding]; other site
443254006216	pullulanase, type I; Region: pulA_typeI; TIGR02104
443254006217	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
443254006218	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
443254006219	Ca binding site [ion binding]; other site
443254006220	active site
443254006221	catalytic site [active]
443254006222	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
443254006223	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
443254006224	MraW methylase family; Region: Methyltransf_5; cl17771
443254006225	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
443254006226	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
443254006227	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
443254006228	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
443254006229	HD domain; Region: HD_3; cl17350
443254006230	Archaeal ATPase; Region: Arch_ATPase; pfam01637
443254006231	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254006232	metal binding site [ion binding]; metal-binding site
443254006233	active site
443254006234	I-site; other site
443254006235	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
443254006236	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
443254006237	active site
443254006238	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
443254006239	FlaG protein; Region: FlaG; pfam03646
443254006240	flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664
443254006241	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
443254006242	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
443254006243	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
443254006244	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
443254006245	active site
443254006246	Zn binding site [ion binding]; other site
443254006247	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
443254006248	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
443254006249	active site
443254006250	substrate binding site [chemical binding]; other site
443254006251	metal binding site [ion binding]; metal-binding site
443254006252	Response regulator receiver domain; Region: Response_reg; pfam00072
443254006253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254006254	active site
443254006255	phosphorylation site [posttranslational modification]
443254006256	intermolecular recognition site; other site
443254006257	dimerization interface [polypeptide binding]; other site
443254006258	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254006259	ATP binding site [chemical binding]; other site
443254006260	Mg2+ binding site [ion binding]; other site
443254006261	G-X-G motif; other site
443254006262	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
443254006263	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
443254006264	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
443254006265	homodimer interface [polypeptide binding]; other site
443254006266	NADP binding site [chemical binding]; other site
443254006267	substrate binding site [chemical binding]; other site
443254006268	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
443254006269	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
443254006270	Potassium binding sites [ion binding]; other site
443254006271	Cesium cation binding sites [ion binding]; other site
443254006272	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
443254006273	dimer interface [polypeptide binding]; other site
443254006274	putative CheW interface [polypeptide binding]; other site
443254006275	Response regulator receiver domain; Region: Response_reg; pfam00072
443254006276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254006277	active site
443254006278	phosphorylation site [posttranslational modification]
443254006279	intermolecular recognition site; other site
443254006280	dimerization interface [polypeptide binding]; other site
443254006281	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
443254006282	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
443254006283	metal binding site [ion binding]; metal-binding site
443254006284	active site
443254006285	I-site; other site
443254006286	CheB methylesterase; Region: CheB_methylest; pfam01339
443254006287	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
443254006288	putative binding surface; other site
443254006289	active site
443254006290	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
443254006291	ATP binding site [chemical binding]; other site
443254006292	Mg2+ binding site [ion binding]; other site
443254006293	G-X-G motif; other site
443254006294	Response regulator receiver domain; Region: Response_reg; pfam00072
443254006295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
443254006296	active site
443254006297	phosphorylation site [posttranslational modification]
443254006298	intermolecular recognition site; other site
443254006299	dimerization interface [polypeptide binding]; other site
443254006300	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
443254006301	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
443254006302	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
443254006303	Zn2+ binding site [ion binding]; other site
443254006304	Mg2+ binding site [ion binding]; other site
443254006305	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
443254006306	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
443254006307	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
443254006308	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
443254006309	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
443254006310	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
443254006311	putative ligand binding site [chemical binding]; other site
443254006312	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
443254006313	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
443254006314	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
443254006315	Predicted ATPase [General function prediction only]; Region: COG4637
443254006316	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
443254006317	Interdomain contacts; other site
443254006318	Cytokine receptor motif; other site
443254006319	Uncharacterized conserved protein [Function unknown]; Region: COG5276
443254006320	LVIVD repeat; Region: LVIVD; pfam08309
443254006321	LVIVD repeat; Region: LVIVD; pfam08309
443254006322	LVIVD repeat; Region: LVIVD; pfam08309
443254006323	LVIVD repeat; Region: LVIVD; pfam08309
443254006324	LVIVD repeat; Region: LVIVD; pfam08309
443254006325	LVIVD repeat; Region: LVIVD; pfam08309
443254006326	LVIVD repeat; Region: LVIVD; pfam08309
443254006327	TM1410 hypothetical-related protein; Region: DUF297; cl00997
443254006328	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
443254006329	EamA-like transporter family; Region: EamA; cl17759
443254006330	EamA-like transporter family; Region: EamA; pfam00892
443254006331	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769
443254006332	SxDxEG motif; other site
443254006333	putative active site [active]
443254006334	putative metal binding site [ion binding]; other site
443254006335	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
443254006336	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
443254006337	minor groove reading motif; other site
443254006338	helix-hairpin-helix signature motif; other site
443254006339	substrate binding pocket [chemical binding]; other site
443254006340	active site
443254006341	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
443254006342	glyoxylate reductase; Reviewed; Region: PRK13243
443254006343	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
443254006344	dimerization interface [polypeptide binding]; other site
443254006345	ligand binding site [chemical binding]; other site
443254006346	NADP binding site [chemical binding]; other site
443254006347	catalytic site [active]
443254006348	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
443254006349	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
443254006350	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
443254006351	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
443254006352	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
443254006353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
443254006354	putative substrate translocation pore; other site
443254006355	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
443254006356	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
443254006357	active site
443254006358	Zn binding site [ion binding]; other site
443254006359	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
443254006360	active site
443254006361	catalytic residues [active]
443254006362	galactokinase; Provisional; Region: PRK03817
443254006363	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
443254006364	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
443254006365	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
443254006366	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
443254006367	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
443254006368	dimer interface [polypeptide binding]; other site
443254006369	active site
443254006370	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
443254006371	Melibiase; Region: Melibiase; pfam02065
443254006372	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
443254006373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254006374	dimer interface [polypeptide binding]; other site
443254006375	conserved gate region; other site
443254006376	putative PBP binding loops; other site
443254006377	ABC-ATPase subunit interface; other site
443254006378	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254006379	dimer interface [polypeptide binding]; other site
443254006380	conserved gate region; other site
443254006381	putative PBP binding loops; other site
443254006382	ABC-ATPase subunit interface; other site
443254006383	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
443254006384	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
443254006385	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
443254006386	Transcriptional regulators [Transcription]; Region: PurR; COG1609
443254006387	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
443254006388	DNA binding site [nucleotide binding]
443254006389	domain linker motif; other site
443254006390	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
443254006391	dimerization interface [polypeptide binding]; other site
443254006392	ligand binding site [chemical binding]; other site
443254006393	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
443254006394	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
443254006395	Transcriptional regulators [Transcription]; Region: PurR; COG1609
443254006396	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
443254006397	DNA binding site [nucleotide binding]
443254006398	domain linker motif; other site
443254006399	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
443254006400	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
443254006401	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
443254006402	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
443254006403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254006404	dimer interface [polypeptide binding]; other site
443254006405	putative PBP binding loops; other site
443254006406	ABC-ATPase subunit interface; other site
443254006407	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
443254006408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254006409	dimer interface [polypeptide binding]; other site
443254006410	conserved gate region; other site
443254006411	putative PBP binding loops; other site
443254006412	ABC-ATPase subunit interface; other site
443254006413	Domain of unknown function (DUF377); Region: DUF377; pfam04041
443254006414	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
443254006415	active site
443254006416	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
443254006417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
443254006418	H+ Antiporter protein; Region: 2A0121; TIGR00900
443254006419	putative substrate translocation pore; other site
443254006420	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
443254006421	putative kinase; Provisional; Region: PRK09954
443254006422	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
443254006423	putative DNA binding site [nucleotide binding]; other site
443254006424	putative Zn2+ binding site [ion binding]; other site
443254006425	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
443254006426	substrate binding site [chemical binding]; other site
443254006427	ATP binding site [chemical binding]; other site
443254006428	Predicted membrane protein [Function unknown]; Region: COG3462
443254006429	Short C-terminal domain; Region: SHOCT; pfam09851
443254006430	Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968
443254006431	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048
443254006432	diiron binding motif [ion binding]; other site
443254006433	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
443254006434	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
443254006435	FeS/SAM binding site; other site
443254006436	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
443254006437	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cl10037
443254006438	homotrimer interaction site [polypeptide binding]; other site
443254006439	active site
443254006440	hybrid cluster protein; Provisional; Region: PRK05290
443254006441	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
443254006442	ACS interaction site; other site
443254006443	CODH interaction site; other site
443254006444	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
443254006445	ACS interaction site; other site
443254006446	CODH interaction site; other site
443254006447	metal cluster binding site [ion binding]; other site
443254006448	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
443254006449	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
443254006450	Flavodoxin domain; Region: Flavodoxin_5; cl17428
443254006451	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
443254006452	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
443254006453	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
443254006454	Major Facilitator Superfamily; Region: MFS_1; pfam07690
443254006455	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254006456	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
443254006457	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
443254006458	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
443254006459	Walker A/P-loop; other site
443254006460	ATP binding site [chemical binding]; other site
443254006461	Q-loop/lid; other site
443254006462	ABC transporter signature motif; other site
443254006463	Walker B; other site
443254006464	D-loop; other site
443254006465	H-loop/switch region; other site
443254006466	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
443254006467	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
443254006468	active site
443254006469	dimer interface [polypeptide binding]; other site
443254006470	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
443254006471	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
443254006472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254006473	dimer interface [polypeptide binding]; other site
443254006474	conserved gate region; other site
443254006475	putative PBP binding loops; other site
443254006476	ABC-ATPase subunit interface; other site
443254006477	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
443254006478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
443254006479	dimer interface [polypeptide binding]; other site
443254006480	conserved gate region; other site
443254006481	putative PBP binding loops; other site
443254006482	ABC-ATPase subunit interface; other site
443254006483	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
443254006484	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
443254006485	Walker A/P-loop; other site
443254006486	ATP binding site [chemical binding]; other site
443254006487	Q-loop/lid; other site
443254006488	ABC transporter signature motif; other site
443254006489	Walker B; other site
443254006490	D-loop; other site
443254006491	H-loop/switch region; other site
443254006492	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
443254006493	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
443254006494	Transcriptional regulators [Transcription]; Region: PurR; COG1609
443254006495	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
443254006496	DNA binding site [nucleotide binding]
443254006497	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
443254006498	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
443254006499	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
443254006500	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
443254006501	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
443254006502	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
443254006503	Walker A motif; other site
443254006504	ATP binding site [chemical binding]; other site
443254006505	Walker B motif; other site
443254006506	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
443254006507	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
443254006508	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
443254006509	intersubunit interface [polypeptide binding]; other site
443254006510	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
443254006511	metal binding site 2 [ion binding]; metal-binding site
443254006512	putative DNA binding helix; other site
443254006513	metal binding site 1 [ion binding]; metal-binding site
443254006514	dimer interface [polypeptide binding]; other site
443254006515	structural Zn2+ binding site [ion binding]; other site
443254006516	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
443254006517	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
443254006518	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
443254006519	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
443254006520	ABC-ATPase subunit  interface; other site
443254006521	dimer interface [polypeptide binding]; other site
443254006522	putative PBP binding regions; other site
443254006523	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
443254006524	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
443254006525	Cl binding site [ion binding]; other site
443254006526	oligomer interface [polypeptide binding]; other site
443254006527	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
443254006528	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
443254006529	Walker A/P-loop; other site
443254006530	ATP binding site [chemical binding]; other site
443254006531	Q-loop/lid; other site
443254006532	ABC transporter signature motif; other site
443254006533	Walker B; other site
443254006534	D-loop; other site
443254006535	H-loop/switch region; other site
443254006536	thymidine kinase; Provisional; Region: PRK04296
443254006537	Competence protein; Region: Competence; pfam03772
443254006538	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135
443254006539	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
443254006540	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
443254006541	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
443254006542	motif II; other site
443254006543	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
443254006544	Domain of unknown function (DUF364); Region: DUF364; pfam04016
443254006545	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956