-- dump date   	20140619_135852
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
490759000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
490759000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
490759000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759000004	Walker A motif; other site
490759000005	ATP binding site [chemical binding]; other site
490759000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
490759000007	Walker B motif; other site
490759000008	arginine finger; other site
490759000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
490759000010	DnaA box-binding interface [nucleotide binding]; other site
490759000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
490759000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
490759000013	putative DNA binding surface [nucleotide binding]; other site
490759000014	dimer interface [polypeptide binding]; other site
490759000015	beta-clamp/clamp loader binding surface; other site
490759000016	beta-clamp/translesion DNA polymerase binding surface; other site
490759000017	ABC1 family; Region: ABC1; cl17513
490759000018	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
490759000019	recombination protein F; Reviewed; Region: recF; PRK00064
490759000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759000021	Walker A/P-loop; other site
490759000022	ATP binding site [chemical binding]; other site
490759000023	Q-loop/lid; other site
490759000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759000025	ABC transporter signature motif; other site
490759000026	Walker B; other site
490759000027	D-loop; other site
490759000028	H-loop/switch region; other site
490759000029	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
490759000030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759000031	Mg2+ binding site [ion binding]; other site
490759000032	G-X-G motif; other site
490759000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
490759000034	anchoring element; other site
490759000035	dimer interface [polypeptide binding]; other site
490759000036	ATP binding site [chemical binding]; other site
490759000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
490759000038	active site
490759000039	putative metal-binding site [ion binding]; other site
490759000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
490759000041	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
490759000042	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
490759000043	inhibitor-cofactor binding pocket; inhibition site
490759000044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759000045	catalytic residue [active]
490759000046	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
490759000047	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
490759000048	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759000049	Walker A/P-loop; other site
490759000050	ATP binding site [chemical binding]; other site
490759000051	Q-loop/lid; other site
490759000052	ABC transporter signature motif; other site
490759000053	Walker B; other site
490759000054	D-loop; other site
490759000055	H-loop/switch region; other site
490759000056	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
490759000057	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
490759000058	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
490759000059	Walker A/P-loop; other site
490759000060	ATP binding site [chemical binding]; other site
490759000061	Q-loop/lid; other site
490759000062	ABC transporter signature motif; other site
490759000063	Walker B; other site
490759000064	D-loop; other site
490759000065	H-loop/switch region; other site
490759000066	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
490759000067	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
490759000068	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
490759000069	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
490759000070	molybdopterin cofactor binding site [chemical binding]; other site
490759000071	substrate binding site [chemical binding]; other site
490759000072	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
490759000073	molybdopterin cofactor binding site; other site
490759000074	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
490759000075	AAA domain; Region: AAA_30; pfam13604
490759000076	Family description; Region: UvrD_C_2; pfam13538
490759000077	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
490759000078	Family description; Region: UvrD_C_2; pfam13538
490759000079	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
490759000080	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
490759000081	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
490759000082	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
490759000083	DEAD_2; Region: DEAD_2; pfam06733
490759000084	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
490759000085	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
490759000086	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
490759000087	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
490759000088	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
490759000089	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
490759000090	HlyD family secretion protein; Region: HlyD_3; pfam13437
490759000091	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
490759000092	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
490759000093	Walker A/P-loop; other site
490759000094	ATP binding site [chemical binding]; other site
490759000095	Q-loop/lid; other site
490759000096	ABC transporter signature motif; other site
490759000097	Walker B; other site
490759000098	D-loop; other site
490759000099	H-loop/switch region; other site
490759000100	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
490759000101	Walker A/P-loop; other site
490759000102	ATP binding site [chemical binding]; other site
490759000103	Q-loop/lid; other site
490759000104	ABC transporter signature motif; other site
490759000105	Walker B; other site
490759000106	D-loop; other site
490759000107	H-loop/switch region; other site
490759000108	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
490759000109	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
490759000110	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
490759000111	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
490759000112	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
490759000113	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
490759000114	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
490759000115	homotrimer interaction site [polypeptide binding]; other site
490759000116	putative active site [active]
490759000117	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
490759000118	putative active site pocket [active]
490759000119	dimerization interface [polypeptide binding]; other site
490759000120	putative catalytic residue [active]
490759000121	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
490759000122	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
490759000123	MPT binding site; other site
490759000124	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
490759000125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759000126	active site
490759000127	motif I; other site
490759000128	motif II; other site
490759000129	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
490759000130	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
490759000131	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
490759000132	dimer interface [polypeptide binding]; other site
490759000133	motif 1; other site
490759000134	active site
490759000135	motif 2; other site
490759000136	motif 3; other site
490759000137	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
490759000138	TrkA-N domain; Region: TrkA_N; pfam02254
490759000139	TrkA-C domain; Region: TrkA_C; pfam02080
490759000140	TrkA-N domain; Region: TrkA_N; pfam02254
490759000141	TrkA-C domain; Region: TrkA_C; pfam02080
490759000142	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
490759000143	putative RNA binding site [nucleotide binding]; other site
490759000144	16S rRNA methyltransferase B; Provisional; Region: PRK10901
490759000145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759000146	S-adenosylmethionine binding site [chemical binding]; other site
490759000147	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
490759000148	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
490759000149	putative active site [active]
490759000150	substrate binding site [chemical binding]; other site
490759000151	putative cosubstrate binding site; other site
490759000152	catalytic site [active]
490759000153	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
490759000154	substrate binding site [chemical binding]; other site
490759000155	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
490759000156	active site
490759000157	catalytic residues [active]
490759000158	metal binding site [ion binding]; metal-binding site
490759000159	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
490759000160	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
490759000161	DNA protecting protein DprA; Region: dprA; TIGR00732
490759000162	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
490759000163	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
490759000164	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
490759000165	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
490759000166	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
490759000167	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
490759000168	shikimate binding site; other site
490759000169	NAD(P) binding site [chemical binding]; other site
490759000170	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
490759000171	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
490759000172	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
490759000173	ligand binding site [chemical binding]; other site
490759000174	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
490759000175	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
490759000176	trimer interface [polypeptide binding]; other site
490759000177	putative metal binding site [ion binding]; other site
490759000178	oligopeptidase A; Provisional; Region: PRK10911
490759000179	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
490759000180	active site
490759000181	Zn binding site [ion binding]; other site
490759000182	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
490759000183	Predicted permease [General function prediction only]; Region: COG2056
490759000184	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
490759000185	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
490759000186	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
490759000187	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759000188	metal binding site [ion binding]; metal-binding site
490759000189	active site
490759000190	I-site; other site
490759000191	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759000192	Predicted membrane protein [Function unknown]; Region: COG2259
490759000193	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
490759000194	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
490759000195	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
490759000196	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
490759000197	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
490759000198	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
490759000199	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
490759000200	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
490759000201	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
490759000202	Subunit I/III interface [polypeptide binding]; other site
490759000203	D-pathway; other site
490759000204	Subunit I/VIIc interface [polypeptide binding]; other site
490759000205	Subunit I/IV interface [polypeptide binding]; other site
490759000206	Subunit I/II interface [polypeptide binding]; other site
490759000207	Low-spin heme (heme a) binding site [chemical binding]; other site
490759000208	Subunit I/VIIa interface [polypeptide binding]; other site
490759000209	Subunit I/VIa interface [polypeptide binding]; other site
490759000210	Dimer interface; other site
490759000211	Putative water exit pathway; other site
490759000212	Binuclear center (heme a3/CuB) [ion binding]; other site
490759000213	K-pathway; other site
490759000214	Subunit I/Vb interface [polypeptide binding]; other site
490759000215	Putative proton exit pathway; other site
490759000216	Subunit I/VIb interface; other site
490759000217	Subunit I/VIc interface [polypeptide binding]; other site
490759000218	Electron transfer pathway; other site
490759000219	Subunit I/VIIIb interface [polypeptide binding]; other site
490759000220	Subunit I/VIIb interface [polypeptide binding]; other site
490759000221	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
490759000222	Subunit III/VIIa interface [polypeptide binding]; other site
490759000223	Phospholipid binding site [chemical binding]; other site
490759000224	Subunit I/III interface [polypeptide binding]; other site
490759000225	Subunit III/VIb interface [polypeptide binding]; other site
490759000226	Subunit III/VIa interface; other site
490759000227	Subunit III/Vb interface [polypeptide binding]; other site
490759000228	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
490759000229	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
490759000230	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
490759000231	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
490759000232	UbiA prenyltransferase family; Region: UbiA; pfam01040
490759000233	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
490759000234	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
490759000235	Cu(I) binding site [ion binding]; other site
490759000236	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
490759000237	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
490759000238	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
490759000239	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
490759000240	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
490759000241	sequence-specific DNA binding site [nucleotide binding]; other site
490759000242	salt bridge; other site
490759000243	Cupin domain; Region: Cupin_2; pfam07883
490759000244	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
490759000245	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
490759000246	dimerization interface [polypeptide binding]; other site
490759000247	ligand binding site [chemical binding]; other site
490759000248	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
490759000249	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
490759000250	TM-ABC transporter signature motif; other site
490759000251	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
490759000252	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
490759000253	TM-ABC transporter signature motif; other site
490759000254	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
490759000255	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
490759000256	Walker A/P-loop; other site
490759000257	ATP binding site [chemical binding]; other site
490759000258	Q-loop/lid; other site
490759000259	ABC transporter signature motif; other site
490759000260	Walker B; other site
490759000261	D-loop; other site
490759000262	H-loop/switch region; other site
490759000263	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
490759000264	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
490759000265	Walker A/P-loop; other site
490759000266	ATP binding site [chemical binding]; other site
490759000267	Q-loop/lid; other site
490759000268	ABC transporter signature motif; other site
490759000269	Walker B; other site
490759000270	D-loop; other site
490759000271	H-loop/switch region; other site
490759000272	acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910
490759000273	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
490759000274	metal binding site [ion binding]; metal-binding site
490759000275	dimer interface [polypeptide binding]; other site
490759000276	indole-3-acetamide amidohydrolase; Region: PLN02722
490759000277	Amidase; Region: Amidase; cl11426
490759000278	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759000279	transposase/IS protein; Provisional; Region: PRK09183
490759000280	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759000281	Walker A motif; other site
490759000282	ATP binding site [chemical binding]; other site
490759000283	Walker B motif; other site
490759000284	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
490759000285	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
490759000286	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
490759000287	ATP binding site [chemical binding]; other site
490759000288	putative Mg++ binding site [ion binding]; other site
490759000289	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759000290	nucleotide binding region [chemical binding]; other site
490759000291	ATP-binding site [chemical binding]; other site
490759000292	Helicase associated domain (HA2); Region: HA2; pfam04408
490759000293	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
490759000294	ATP-grasp domain; Region: ATP-grasp_4; cl17255
490759000295	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
490759000296	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
490759000297	dimer interface [polypeptide binding]; other site
490759000298	active site
490759000299	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
490759000300	catalytic residues [active]
490759000301	substrate binding site [chemical binding]; other site
490759000302	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
490759000303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759000304	putative substrate translocation pore; other site
490759000305	L-ectoine synthase; Reviewed; Region: ectC; PRK13290
490759000306	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
490759000307	G1 box; other site
490759000308	GTP/Mg2+ binding site [chemical binding]; other site
490759000309	G2 box; other site
490759000310	Switch I region; other site
490759000311	G3 box; other site
490759000312	Switch II region; other site
490759000313	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
490759000314	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
490759000315	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
490759000316	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
490759000317	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
490759000318	PAS fold; Region: PAS_4; pfam08448
490759000319	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759000320	putative active site [active]
490759000321	heme pocket [chemical binding]; other site
490759000322	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
490759000323	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759000324	Walker A motif; other site
490759000325	ATP binding site [chemical binding]; other site
490759000326	Walker B motif; other site
490759000327	arginine finger; other site
490759000328	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759000329	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
490759000330	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759000331	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
490759000332	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
490759000333	DctM-like transporters; Region: DctM; pfam06808
490759000334	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
490759000335	classical (c) SDRs; Region: SDR_c; cd05233
490759000336	NAD(P) binding site [chemical binding]; other site
490759000337	active site
490759000338	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
490759000339	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
490759000340	acyl-activating enzyme (AAE) consensus motif; other site
490759000341	AMP binding site [chemical binding]; other site
490759000342	active site
490759000343	CoA binding site [chemical binding]; other site
490759000344	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
490759000345	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
490759000346	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
490759000347	putative deacylase active site [active]
490759000348	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
490759000349	putative active site [active]
490759000350	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759000351	TPR repeat; Region: TPR_11; pfam13414
490759000352	binding surface
490759000353	TPR motif; other site
490759000354	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
490759000355	Beta-lactamase; Region: Beta-lactamase; pfam00144
490759000356	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
490759000357	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
490759000358	Ligand Binding Site [chemical binding]; other site
490759000359	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
490759000360	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
490759000361	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
490759000362	generic binding surface II; other site
490759000363	generic binding surface I; other site
490759000364	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
490759000365	putative catalytic site [active]
490759000366	putative metal binding site [ion binding]; other site
490759000367	putative phosphate binding site [ion binding]; other site
490759000368	Predicted transcriptional regulator [Transcription]; Region: COG2378
490759000369	WYL domain; Region: WYL; pfam13280
490759000370	Major Facilitator Superfamily; Region: MFS_1; pfam07690
490759000371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759000372	putative substrate translocation pore; other site
490759000373	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
490759000374	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
490759000375	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759000376	Major Facilitator Superfamily; Region: MFS_1; pfam07690
490759000377	putative substrate translocation pore; other site
490759000378	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759000379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
490759000380	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
490759000381	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
490759000382	potassium/proton antiporter; Reviewed; Region: PRK05326
490759000383	Transporter associated domain; Region: CorC_HlyC; smart01091
490759000384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759000385	putative substrate translocation pore; other site
490759000386	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759000387	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
490759000388	PBP superfamily domain; Region: PBP_like; pfam12727
490759000389	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
490759000390	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
490759000391	putative dimer interface [polypeptide binding]; other site
490759000392	[2Fe-2S] cluster binding site [ion binding]; other site
490759000393	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
490759000394	putative dimer interface [polypeptide binding]; other site
490759000395	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
490759000396	SLBB domain; Region: SLBB; pfam10531
490759000397	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
490759000398	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
490759000399	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
490759000400	catalytic loop [active]
490759000401	iron binding site [ion binding]; other site
490759000402	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
490759000403	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
490759000404	[4Fe-4S] binding site [ion binding]; other site
490759000405	molybdopterin cofactor binding site; other site
490759000406	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
490759000407	molybdopterin cofactor binding site; other site
490759000408	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
490759000409	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
490759000410	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
490759000411	GAF domain; Region: GAF; pfam01590
490759000412	GAF domain; Region: GAF_2; pfam13185
490759000413	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759000414	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759000415	metal binding site [ion binding]; metal-binding site
490759000416	active site
490759000417	I-site; other site
490759000418	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759000419	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
490759000420	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759000421	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
490759000422	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
490759000423	substrate binding site [chemical binding]; other site
490759000424	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
490759000425	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
490759000426	active site residue [active]
490759000427	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
490759000428	active site residue [active]
490759000429	putative inner membrane protein; Provisional; Region: PRK11099
490759000430	Uncharacterized conserved protein [Function unknown]; Region: COG0398
490759000431	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
490759000432	Phosphotransferase enzyme family; Region: APH; pfam01636
490759000433	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
490759000434	active site
490759000435	ATP binding site [chemical binding]; other site
490759000436	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
490759000437	substrate binding site [chemical binding]; other site
490759000438	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
490759000439	hypothetical protein; Provisional; Region: PRK11622
490759000440	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
490759000441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759000442	putative PBP binding loops; other site
490759000443	dimer interface [polypeptide binding]; other site
490759000444	ABC-ATPase subunit interface; other site
490759000445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759000446	Walker A/P-loop; other site
490759000447	ATP binding site [chemical binding]; other site
490759000448	ABC transporter; Region: ABC_tran; pfam00005
490759000449	Q-loop/lid; other site
490759000450	ABC transporter signature motif; other site
490759000451	Walker B; other site
490759000452	D-loop; other site
490759000453	H-loop/switch region; other site
490759000454	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
490759000455	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759000456	NAD(P) binding site [chemical binding]; other site
490759000457	active site
490759000458	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
490759000459	acetolactate synthase; Reviewed; Region: PRK08322
490759000460	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
490759000461	PYR/PP interface [polypeptide binding]; other site
490759000462	dimer interface [polypeptide binding]; other site
490759000463	TPP binding site [chemical binding]; other site
490759000464	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
490759000465	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
490759000466	TPP-binding site [chemical binding]; other site
490759000467	dimer interface [polypeptide binding]; other site
490759000468	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
490759000469	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
490759000470	DNA binding residues [nucleotide binding]
490759000471	dimer interface [polypeptide binding]; other site
490759000472	mercury binding site [ion binding]; other site
490759000473	MerT mercuric transport protein; Region: MerT; cl03578
490759000474	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
490759000475	metal-binding site [ion binding]
490759000476	Membrane transport protein MerF; Region: Transport_MerF; pfam11431
490759000477	putative mercuric reductase; Provisional; Region: PRK14694
490759000478	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759000479	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
490759000480	Tubulin-tyrosine ligase family; Region: TTL; pfam03133
490759000481	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
490759000482	Cytochrome c [Energy production and conversion]; Region: COG3258
490759000483	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
490759000484	EthD domain; Region: EthD; cl17553
490759000485	Putative zinc-finger; Region: zf-HC2; pfam13490
490759000486	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
490759000487	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
490759000488	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
490759000489	DNA binding residues [nucleotide binding]
490759000490	Uncharacterized conserved protein [Function unknown]; Region: COG0398
490759000491	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
490759000492	mercuric reductase; Validated; Region: PRK06370
490759000493	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759000494	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
490759000495	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
490759000496	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
490759000497	FeS/SAM binding site; other site
490759000498	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
490759000499	dimer interaction site [polypeptide binding]; other site
490759000500	substrate-binding tunnel; other site
490759000501	active site
490759000502	catalytic site [active]
490759000503	substrate binding site [chemical binding]; other site
490759000504	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
490759000505	Coenzyme A binding pocket [chemical binding]; other site
490759000506	aspartate kinase; Validated; Region: PRK09181
490759000507	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
490759000508	nucleotide binding site [chemical binding]; other site
490759000509	substrate binding site [chemical binding]; other site
490759000510	ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_1; cd04910
490759000511	allosteric regulatory residue; other site
490759000512	ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_2; cd04915
490759000513	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
490759000514	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
490759000515	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
490759000516	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
490759000517	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
490759000518	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
490759000519	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
490759000520	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
490759000521	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
490759000522	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
490759000523	ligand binding site [chemical binding]; other site
490759000524	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
490759000525	Zn2+ binding site [ion binding]; other site
490759000526	Mg2+ binding site [ion binding]; other site
490759000527	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
490759000528	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
490759000529	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
490759000530	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
490759000531	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
490759000532	putative active site [active]
490759000533	putative dimer interface [polypeptide binding]; other site
490759000534	TM2 domain; Region: TM2; cl00984
490759000535	Protein of unknown function (DUF796); Region: DUF796; cl01226
490759000536	Protein of unknown function (DUF796); Region: DUF796; cl01226
490759000537	Cache domain; Region: Cache_1; pfam02743
490759000538	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759000539	PAS domain; Region: PAS_9; pfam13426
490759000540	putative active site [active]
490759000541	heme pocket [chemical binding]; other site
490759000542	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759000543	PAS domain; Region: PAS_9; pfam13426
490759000544	putative active site [active]
490759000545	heme pocket [chemical binding]; other site
490759000546	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759000547	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759000548	metal binding site [ion binding]; metal-binding site
490759000549	active site
490759000550	I-site; other site
490759000551	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
490759000552	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
490759000553	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
490759000554	Walker A/P-loop; other site
490759000555	ATP binding site [chemical binding]; other site
490759000556	Q-loop/lid; other site
490759000557	ABC transporter signature motif; other site
490759000558	Walker B; other site
490759000559	D-loop; other site
490759000560	H-loop/switch region; other site
490759000561	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
490759000562	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759000563	dimer interface [polypeptide binding]; other site
490759000564	conserved gate region; other site
490759000565	putative PBP binding loops; other site
490759000566	ABC-ATPase subunit interface; other site
490759000567	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
490759000568	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
490759000569	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
490759000570	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
490759000571	FOG: CBS domain [General function prediction only]; Region: COG0517
490759000572	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
490759000573	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
490759000574	S-formylglutathione hydrolase; Region: PLN02442
490759000575	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
490759000576	multidrug efflux protein; Reviewed; Region: PRK01766
490759000577	cation binding site [ion binding]; other site
490759000578	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
490759000579	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
490759000580	Na2 binding site [ion binding]; other site
490759000581	putative substrate binding site 1 [chemical binding]; other site
490759000582	Na binding site 1 [ion binding]; other site
490759000583	putative substrate binding site 2 [chemical binding]; other site
490759000584	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
490759000585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759000586	active site
490759000587	phosphorylation site [posttranslational modification]
490759000588	intermolecular recognition site; other site
490759000589	dimerization interface [polypeptide binding]; other site
490759000590	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
490759000591	DNA binding site [nucleotide binding]
490759000592	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
490759000593	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759000594	dimer interface [polypeptide binding]; other site
490759000595	phosphorylation site [posttranslational modification]
490759000596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759000597	ATP binding site [chemical binding]; other site
490759000598	Mg2+ binding site [ion binding]; other site
490759000599	G-X-G motif; other site
490759000600	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
490759000601	methionine sulfoxide reductase B; Provisional; Region: PRK00222
490759000602	SelR domain; Region: SelR; pfam01641
490759000603	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
490759000604	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
490759000605	active site
490759000606	catalytic site [active]
490759000607	substrate binding site [chemical binding]; other site
490759000608	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
490759000609	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
490759000610	ligand binding site [chemical binding]; other site
490759000611	flexible hinge region; other site
490759000612	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
490759000613	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
490759000614	metal binding triad; other site
490759000615	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
490759000616	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759000617	putative active site [active]
490759000618	heme pocket [chemical binding]; other site
490759000619	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759000620	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759000621	metal binding site [ion binding]; metal-binding site
490759000622	active site
490759000623	I-site; other site
490759000624	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759000625	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
490759000626	catalytic core [active]
490759000627	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
490759000628	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
490759000629	putative dimer interface [polypeptide binding]; other site
490759000630	active site pocket [active]
490759000631	putative cataytic base [active]
490759000632	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
490759000633	homotrimer interface [polypeptide binding]; other site
490759000634	Walker A motif; other site
490759000635	GTP binding site [chemical binding]; other site
490759000636	Walker B motif; other site
490759000637	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
490759000638	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
490759000639	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
490759000640	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759000641	homodimer interface [polypeptide binding]; other site
490759000642	catalytic residue [active]
490759000643	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
490759000644	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
490759000645	N-terminal plug; other site
490759000646	ligand-binding site [chemical binding]; other site
490759000647	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
490759000648	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
490759000649	cobalamin binding residues [chemical binding]; other site
490759000650	putative BtuC binding residues; other site
490759000651	dimer interface [polypeptide binding]; other site
490759000652	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
490759000653	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
490759000654	ABC-ATPase subunit  interface; other site
490759000655	dimer interface [polypeptide binding]; other site
490759000656	putative PBP binding regions; other site
490759000657	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
490759000658	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
490759000659	Walker A/P-loop; other site
490759000660	ATP binding site [chemical binding]; other site
490759000661	Q-loop/lid; other site
490759000662	ABC transporter signature motif; other site
490759000663	Walker B; other site
490759000664	D-loop; other site
490759000665	H-loop/switch region; other site
490759000666	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
490759000667	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
490759000668	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
490759000669	catalytic triad [active]
490759000670	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
490759000671	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
490759000672	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
490759000673	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
490759000674	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
490759000675	homodimer interface [polypeptide binding]; other site
490759000676	Walker A motif; other site
490759000677	ATP binding site [chemical binding]; other site
490759000678	hydroxycobalamin binding site [chemical binding]; other site
490759000679	Walker B motif; other site
490759000680	cobyric acid synthase; Provisional; Region: PRK00784
490759000681	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
490759000682	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
490759000683	catalytic triad [active]
490759000684	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
490759000685	putative FMN binding site [chemical binding]; other site
490759000686	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759000687	dimer interface [polypeptide binding]; other site
490759000688	phosphorylation site [posttranslational modification]
490759000689	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759000690	ATP binding site [chemical binding]; other site
490759000691	Mg2+ binding site [ion binding]; other site
490759000692	G-X-G motif; other site
490759000693	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
490759000694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759000695	active site
490759000696	phosphorylation site [posttranslational modification]
490759000697	intermolecular recognition site; other site
490759000698	dimerization interface [polypeptide binding]; other site
490759000699	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
490759000700	DNA binding site [nucleotide binding]
490759000701	Thermostable hemolysin; Region: T_hemolysin; pfam12261
490759000702	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
490759000703	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914
490759000704	acyl-activating enzyme (AAE) consensus motif; other site
490759000705	putative AMP binding site [chemical binding]; other site
490759000706	putative active site [active]
490759000707	putative CoA binding site [chemical binding]; other site
490759000708	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
490759000709	heme binding pocket [chemical binding]; other site
490759000710	heme ligand [chemical binding]; other site
490759000711	short chain dehydrogenase; Provisional; Region: PRK09072
490759000712	classical (c) SDRs; Region: SDR_c; cd05233
490759000713	NAD(P) binding site [chemical binding]; other site
490759000714	active site
490759000715	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
490759000716	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
490759000717	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
490759000718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
490759000719	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
490759000720	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
490759000721	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
490759000722	Walker A motif; other site
490759000723	ATP binding site [chemical binding]; other site
490759000724	Walker B motif; other site
490759000725	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
490759000726	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
490759000727	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
490759000728	F0F1 ATP synthase subunit C; Provisional; Region: PRK13468
490759000729	ATP synthase A chain; Region: ATP-synt_A; cl00413
490759000730	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
490759000731	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
490759000732	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
490759000733	gamma subunit interface [polypeptide binding]; other site
490759000734	epsilon subunit interface [polypeptide binding]; other site
490759000735	LBP interface [polypeptide binding]; other site
490759000736	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
490759000737	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
490759000738	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
490759000739	alpha subunit interaction interface [polypeptide binding]; other site
490759000740	Walker A motif; other site
490759000741	ATP binding site [chemical binding]; other site
490759000742	Walker B motif; other site
490759000743	inhibitor binding site; inhibition site
490759000744	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
490759000745	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
490759000746	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
490759000747	putative substrate binding site [chemical binding]; other site
490759000748	nucleotide binding site [chemical binding]; other site
490759000749	nucleotide binding site [chemical binding]; other site
490759000750	homodimer interface [polypeptide binding]; other site
490759000751	ornithine carbamoyltransferase; Validated; Region: PRK02102
490759000752	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
490759000753	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
490759000754	arginine deiminase; Provisional; Region: PRK01388
490759000755	Predicted membrane protein [Function unknown]; Region: COG1288
490759000756	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
490759000757	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
490759000758	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
490759000759	cobalamin synthase; Reviewed; Region: cobS; PRK00235
490759000760	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
490759000761	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759000762	substrate binding pocket [chemical binding]; other site
490759000763	membrane-bound complex binding site; other site
490759000764	hinge residues; other site
490759000765	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
490759000766	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759000767	Walker A/P-loop; other site
490759000768	ATP binding site [chemical binding]; other site
490759000769	Q-loop/lid; other site
490759000770	ABC transporter signature motif; other site
490759000771	Walker B; other site
490759000772	D-loop; other site
490759000773	H-loop/switch region; other site
490759000774	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759000775	dimer interface [polypeptide binding]; other site
490759000776	conserved gate region; other site
490759000777	putative PBP binding loops; other site
490759000778	ABC-ATPase subunit interface; other site
490759000779	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
490759000780	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759000781	dimer interface [polypeptide binding]; other site
490759000782	conserved gate region; other site
490759000783	putative PBP binding loops; other site
490759000784	ABC-ATPase subunit interface; other site
490759000785	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
490759000786	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
490759000787	high affinity sulphate transporter 1; Region: sulP; TIGR00815
490759000788	Sulfate transporter family; Region: Sulfate_transp; pfam00916
490759000789	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
490759000790	Predicted membrane protein [Function unknown]; Region: COG3235
490759000791	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
490759000792	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759000793	I-site; other site
490759000794	active site
490759000795	metal binding site [ion binding]; metal-binding site
490759000796	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759000797	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
490759000798	GAF domain; Region: GAF; pfam01590
490759000799	PAS domain; Region: PAS; smart00091
490759000800	PAS fold; Region: PAS_4; pfam08448
490759000801	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759000802	PAS domain; Region: PAS_9; pfam13426
490759000803	putative active site [active]
490759000804	heme pocket [chemical binding]; other site
490759000805	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759000806	PAS fold; Region: PAS_3; pfam08447
490759000807	putative active site [active]
490759000808	heme pocket [chemical binding]; other site
490759000809	PAS domain S-box; Region: sensory_box; TIGR00229
490759000810	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759000811	putative active site [active]
490759000812	heme pocket [chemical binding]; other site
490759000813	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759000814	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
490759000815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759000816	active site
490759000817	dimerization interface [polypeptide binding]; other site
490759000818	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759000819	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
490759000820	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
490759000821	HlyD family secretion protein; Region: HlyD_3; pfam13437
490759000822	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
490759000823	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
490759000824	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
490759000825	Walker A/P-loop; other site
490759000826	ATP binding site [chemical binding]; other site
490759000827	Q-loop/lid; other site
490759000828	ABC transporter signature motif; other site
490759000829	Walker B; other site
490759000830	D-loop; other site
490759000831	H-loop/switch region; other site
490759000832	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
490759000833	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
490759000834	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
490759000835	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
490759000836	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
490759000837	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
490759000838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
490759000839	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
490759000840	Uncharacterized conserved protein [Function unknown]; Region: COG2308
490759000841	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
490759000842	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
490759000843	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
490759000844	ligand binding site [chemical binding]; other site
490759000845	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
490759000846	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
490759000847	Uncharacterized conserved protein [Function unknown]; Region: COG3339
490759000848	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
490759000849	DNA photolyase; Region: DNA_photolyase; pfam00875
490759000850	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
490759000851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759000852	NAD(P) binding site [chemical binding]; other site
490759000853	active site
490759000854	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
490759000855	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
490759000856	FMN binding site [chemical binding]; other site
490759000857	active site
490759000858	substrate binding site [chemical binding]; other site
490759000859	catalytic residue [active]
490759000860	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
490759000861	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
490759000862	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
490759000863	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
490759000864	substrate binding site [chemical binding]; other site
490759000865	catalytic Zn binding site [ion binding]; other site
490759000866	NAD binding site [chemical binding]; other site
490759000867	structural Zn binding site [ion binding]; other site
490759000868	dimer interface [polypeptide binding]; other site
490759000869	hypothetical protein; Validated; Region: PRK09039
490759000870	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
490759000871	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
490759000872	ligand binding site [chemical binding]; other site
490759000873	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
490759000874	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
490759000875	potential catalytic triad [active]
490759000876	conserved cys residue [active]
490759000877	conserved hypothetical protein; Region: MG423; TIGR00649
490759000878	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
490759000879	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
490759000880	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
490759000881	PHB binding site; other site
490759000882	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
490759000883	active site residue [active]
490759000884	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
490759000885	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
490759000886	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759000887	dimerization interface [polypeptide binding]; other site
490759000888	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
490759000889	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759000890	dimer interface [polypeptide binding]; other site
490759000891	putative CheW interface [polypeptide binding]; other site
490759000892	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
490759000893	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759000894	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
490759000895	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
490759000896	Walker A/P-loop; other site
490759000897	ATP binding site [chemical binding]; other site
490759000898	Q-loop/lid; other site
490759000899	ABC transporter signature motif; other site
490759000900	Walker B; other site
490759000901	D-loop; other site
490759000902	H-loop/switch region; other site
490759000903	TOBE domain; Region: TOBE_2; pfam08402
490759000904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759000905	dimer interface [polypeptide binding]; other site
490759000906	conserved gate region; other site
490759000907	putative PBP binding loops; other site
490759000908	ABC-ATPase subunit interface; other site
490759000909	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
490759000910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759000911	dimer interface [polypeptide binding]; other site
490759000912	conserved gate region; other site
490759000913	putative PBP binding loops; other site
490759000914	ABC-ATPase subunit interface; other site
490759000915	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
490759000916	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
490759000917	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759000918	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759000919	metal binding site [ion binding]; metal-binding site
490759000920	active site
490759000921	I-site; other site
490759000922	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
490759000923	Ligand Binding Site [chemical binding]; other site
490759000924	DctM-like transporters; Region: DctM; pfam06808
490759000925	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
490759000926	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
490759000927	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
490759000928	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759000929	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
490759000930	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
490759000931	catalytic residues [active]
490759000932	dimer interface [polypeptide binding]; other site
490759000933	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
490759000934	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
490759000935	Methyltransferase domain; Region: Methyltransf_31; pfam13847
490759000936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759000937	S-adenosylmethionine binding site [chemical binding]; other site
490759000938	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
490759000939	dimer interface [polypeptide binding]; other site
490759000940	FMN binding site [chemical binding]; other site
490759000941	NADPH bind site [chemical binding]; other site
490759000942	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
490759000943	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
490759000944	dimerization domain [polypeptide binding]; other site
490759000945	dimer interface [polypeptide binding]; other site
490759000946	catalytic residues [active]
490759000947	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
490759000948	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
490759000949	catalytic residues [active]
490759000950	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
490759000951	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
490759000952	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
490759000953	Protein export membrane protein; Region: SecD_SecF; cl14618
490759000954	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
490759000955	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
490759000956	hexamer interface [polypeptide binding]; other site
490759000957	ligand binding site [chemical binding]; other site
490759000958	putative active site [active]
490759000959	NAD(P) binding site [chemical binding]; other site
490759000960	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
490759000961	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
490759000962	putative DNA binding site [nucleotide binding]; other site
490759000963	putative Zn2+ binding site [ion binding]; other site
490759000964	AsnC family; Region: AsnC_trans_reg; pfam01037
490759000965	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759000966	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
490759000967	substrate binding pocket [chemical binding]; other site
490759000968	membrane-bound complex binding site; other site
490759000969	hinge residues; other site
490759000970	Predicted permeases [General function prediction only]; Region: COG0679
490759000971	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
490759000972	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
490759000973	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
490759000974	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
490759000975	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
490759000976	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
490759000977	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
490759000978	Zn2+ binding site [ion binding]; other site
490759000979	Mg2+ binding site [ion binding]; other site
490759000980	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
490759000981	GAF domain; Region: GAF; pfam01590
490759000982	PAS domain S-box; Region: sensory_box; TIGR00229
490759000983	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759000984	putative active site [active]
490759000985	heme pocket [chemical binding]; other site
490759000986	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759000987	PAS domain; Region: PAS_9; pfam13426
490759000988	putative active site [active]
490759000989	heme pocket [chemical binding]; other site
490759000990	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759000991	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759000992	metal binding site [ion binding]; metal-binding site
490759000993	active site
490759000994	I-site; other site
490759000995	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759000996	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
490759000997	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
490759000998	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
490759000999	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
490759001000	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
490759001001	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759001002	dimerization interface [polypeptide binding]; other site
490759001003	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759001004	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759001005	metal binding site [ion binding]; metal-binding site
490759001006	active site
490759001007	I-site; other site
490759001008	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759001009	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
490759001010	Helix-turn-helix domain; Region: HTH_18; pfam12833
490759001011	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
490759001012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759001013	active site
490759001014	phosphorylation site [posttranslational modification]
490759001015	intermolecular recognition site; other site
490759001016	dimerization interface [polypeptide binding]; other site
490759001017	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
490759001018	Zn2+ binding site [ion binding]; other site
490759001019	Mg2+ binding site [ion binding]; other site
490759001020	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759001021	PAS domain; Region: PAS_9; pfam13426
490759001022	putative active site [active]
490759001023	heme pocket [chemical binding]; other site
490759001024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759001025	putative active site [active]
490759001026	heme pocket [chemical binding]; other site
490759001027	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
490759001028	GAF domain; Region: GAF; pfam01590
490759001029	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759001030	dimer interface [polypeptide binding]; other site
490759001031	phosphorylation site [posttranslational modification]
490759001032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759001033	ATP binding site [chemical binding]; other site
490759001034	Mg2+ binding site [ion binding]; other site
490759001035	G-X-G motif; other site
490759001036	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
490759001037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759001038	active site
490759001039	phosphorylation site [posttranslational modification]
490759001040	intermolecular recognition site; other site
490759001041	dimerization interface [polypeptide binding]; other site
490759001042	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759001043	PAS domain; Region: PAS_9; pfam13426
490759001044	putative active site [active]
490759001045	heme pocket [chemical binding]; other site
490759001046	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
490759001047	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759001048	dimer interface [polypeptide binding]; other site
490759001049	putative CheW interface [polypeptide binding]; other site
490759001050	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
490759001051	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
490759001052	succinic semialdehyde dehydrogenase; Region: PLN02278
490759001053	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
490759001054	tetramerization interface [polypeptide binding]; other site
490759001055	NAD(P) binding site [chemical binding]; other site
490759001056	catalytic residues [active]
490759001057	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
490759001058	CoA-transferase family III; Region: CoA_transf_3; pfam02515
490759001059	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
490759001060	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
490759001061	FAD binding site [chemical binding]; other site
490759001062	substrate binding pocket [chemical binding]; other site
490759001063	catalytic base [active]
490759001064	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
490759001065	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
490759001066	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759001067	DNA-binding site [nucleotide binding]; DNA binding site
490759001068	FCD domain; Region: FCD; pfam07729
490759001069	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
490759001070	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
490759001071	Cysteine-rich domain; Region: CCG; pfam02754
490759001072	Cysteine-rich domain; Region: CCG; pfam02754
490759001073	FAD binding domain; Region: FAD_binding_4; pfam01565
490759001074	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
490759001075	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
490759001076	FAD binding domain; Region: FAD_binding_4; pfam01565
490759001077	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
490759001078	DctM-like transporters; Region: DctM; pfam06808
490759001079	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
490759001080	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759001081	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
490759001082	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759001083	DNA-binding site [nucleotide binding]; DNA binding site
490759001084	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
490759001085	LrgA family; Region: LrgA; pfam03788
490759001086	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
490759001087	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
490759001088	PAS domain S-box; Region: sensory_box; TIGR00229
490759001089	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759001090	putative active site [active]
490759001091	heme pocket [chemical binding]; other site
490759001092	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759001093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759001094	metal binding site [ion binding]; metal-binding site
490759001095	active site
490759001096	I-site; other site
490759001097	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759001098	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759001099	PAS domain; Region: PAS_9; pfam13426
490759001100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759001101	putative active site [active]
490759001102	heme pocket [chemical binding]; other site
490759001103	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759001104	dimer interface [polypeptide binding]; other site
490759001105	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
490759001106	putative CheW interface [polypeptide binding]; other site
490759001107	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
490759001108	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759001109	dimerization interface [polypeptide binding]; other site
490759001110	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759001111	dimer interface [polypeptide binding]; other site
490759001112	putative CheW interface [polypeptide binding]; other site
490759001113	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759001114	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
490759001115	DctM-like transporters; Region: DctM; pfam06808
490759001116	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
490759001117	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
490759001118	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
490759001119	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
490759001120	Predicted dehydrogenase [General function prediction only]; Region: COG0579
490759001121	hydroxyglutarate oxidase; Provisional; Region: PRK11728
490759001122	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
490759001123	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
490759001124	Proteobacterial glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK_like_proteobact; cd07794
490759001125	N- and C-terminal domain interface [polypeptide binding]; other site
490759001126	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
490759001127	active site
490759001128	MgATP binding site [chemical binding]; other site
490759001129	catalytic site [active]
490759001130	metal binding site [ion binding]; metal-binding site
490759001131	putative homotetramer interface [polypeptide binding]; other site
490759001132	putative homodimer interface [polypeptide binding]; other site
490759001133	putative glycerol binding site [chemical binding]; other site
490759001134	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
490759001135	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
490759001136	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
490759001137	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759001138	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759001139	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759001140	dimerization interface [polypeptide binding]; other site
490759001141	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
490759001142	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
490759001143	serine racemase; Region: PLN02970
490759001144	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
490759001145	tetramer interface [polypeptide binding]; other site
490759001146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759001147	catalytic residue [active]
490759001148	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
490759001149	homodimer interface [polypeptide binding]; other site
490759001150	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759001151	catalytic residue [active]
490759001152	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
490759001153	Transcriptional regulator [Transcription]; Region: IclR; COG1414
490759001154	Bacterial transcriptional regulator; Region: IclR; pfam01614
490759001155	Transcriptional regulators [Transcription]; Region: FadR; COG2186
490759001156	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759001157	DNA-binding site [nucleotide binding]; DNA binding site
490759001158	FCD domain; Region: FCD; pfam07729
490759001159	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
490759001160	Amidase; Region: Amidase; cl11426
490759001161	DctM-like transporters; Region: DctM; pfam06808
490759001162	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
490759001163	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
490759001164	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
490759001165	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
490759001166	Predicted amidohydrolase [General function prediction only]; Region: COG0388
490759001167	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
490759001168	active site
490759001169	catalytic triad [active]
490759001170	dimer interface [polypeptide binding]; other site
490759001171	Transcriptional regulators [Transcription]; Region: FadR; COG2186
490759001172	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759001173	DNA-binding site [nucleotide binding]; DNA binding site
490759001174	FCD domain; Region: FCD; pfam07729
490759001175	Domain of unknown function (DUF336); Region: DUF336; cl01249
490759001176	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
490759001177	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
490759001178	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
490759001179	DctM-like transporters; Region: DctM; pfam06808
490759001180	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
490759001181	enoyl-CoA hydratase; Provisional; Region: PRK06144
490759001182	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759001183	substrate binding site [chemical binding]; other site
490759001184	oxyanion hole (OAH) forming residues; other site
490759001185	trimer interface [polypeptide binding]; other site
490759001186	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
490759001187	homodimer interface [polypeptide binding]; other site
490759001188	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759001189	catalytic residue [active]
490759001190	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
490759001191	FAD binding domain; Region: FAD_binding_4; pfam01565
490759001192	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
490759001193	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
490759001194	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
490759001195	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
490759001196	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
490759001197	homotrimer interaction site [polypeptide binding]; other site
490759001198	putative active site [active]
490759001199	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
490759001200	TPP binding site [chemical binding]; other site
490759001201	succinic semialdehyde dehydrogenase; Region: PLN02278
490759001202	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
490759001203	tetramerization interface [polypeptide binding]; other site
490759001204	NAD(P) binding site [chemical binding]; other site
490759001205	catalytic residues [active]
490759001206	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
490759001207	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
490759001208	putative active site [active]
490759001209	metal binding site [ion binding]; metal-binding site
490759001210	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
490759001211	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
490759001212	Walker A/P-loop; other site
490759001213	ATP binding site [chemical binding]; other site
490759001214	Q-loop/lid; other site
490759001215	ABC transporter signature motif; other site
490759001216	Walker B; other site
490759001217	D-loop; other site
490759001218	H-loop/switch region; other site
490759001219	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
490759001220	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
490759001221	Walker A/P-loop; other site
490759001222	ATP binding site [chemical binding]; other site
490759001223	Q-loop/lid; other site
490759001224	ABC transporter signature motif; other site
490759001225	Walker B; other site
490759001226	D-loop; other site
490759001227	H-loop/switch region; other site
490759001228	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
490759001229	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
490759001230	TM-ABC transporter signature motif; other site
490759001231	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
490759001232	TM-ABC transporter signature motif; other site
490759001233	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
490759001234	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
490759001235	putative ligand binding site [chemical binding]; other site
490759001236	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
490759001237	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
490759001238	putative ligand binding site [chemical binding]; other site
490759001239	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
490759001240	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759001241	active site
490759001242	phosphorylation site [posttranslational modification]
490759001243	intermolecular recognition site; other site
490759001244	dimerization interface [polypeptide binding]; other site
490759001245	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759001246	Walker A motif; other site
490759001247	ATP binding site [chemical binding]; other site
490759001248	Walker B motif; other site
490759001249	arginine finger; other site
490759001250	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
490759001251	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759001252	dimerization interface [polypeptide binding]; other site
490759001253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759001254	dimer interface [polypeptide binding]; other site
490759001255	phosphorylation site [posttranslational modification]
490759001256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759001257	ATP binding site [chemical binding]; other site
490759001258	Mg2+ binding site [ion binding]; other site
490759001259	G-X-G motif; other site
490759001260	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759001261	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
490759001262	Domain of unknown function (DUF373); Region: DUF373; cl12079
490759001263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759001264	dimer interface [polypeptide binding]; other site
490759001265	conserved gate region; other site
490759001266	putative PBP binding loops; other site
490759001267	ABC-ATPase subunit interface; other site
490759001268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759001269	dimer interface [polypeptide binding]; other site
490759001270	conserved gate region; other site
490759001271	putative PBP binding loops; other site
490759001272	ABC-ATPase subunit interface; other site
490759001273	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
490759001274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759001275	Walker A/P-loop; other site
490759001276	ATP binding site [chemical binding]; other site
490759001277	Q-loop/lid; other site
490759001278	ABC transporter signature motif; other site
490759001279	Walker B; other site
490759001280	D-loop; other site
490759001281	H-loop/switch region; other site
490759001282	TOBE domain; Region: TOBE_2; pfam08402
490759001283	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
490759001284	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
490759001285	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
490759001286	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
490759001287	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
490759001288	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
490759001289	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
490759001290	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759001291	DNA-binding site [nucleotide binding]; DNA binding site
490759001292	FCD domain; Region: FCD; pfam07729
490759001293	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
490759001294	succinic semialdehyde dehydrogenase; Region: PLN02278
490759001295	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
490759001296	tetramerization interface [polypeptide binding]; other site
490759001297	NAD(P) binding site [chemical binding]; other site
490759001298	catalytic residues [active]
490759001299	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759001300	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759001301	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
490759001302	dimerization interface [polypeptide binding]; other site
490759001303	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
490759001304	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
490759001305	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
490759001306	active site
490759001307	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
490759001308	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
490759001309	homodimer interface [polypeptide binding]; other site
490759001310	NAD binding pocket [chemical binding]; other site
490759001311	ATP binding pocket [chemical binding]; other site
490759001312	Mg binding site [ion binding]; other site
490759001313	active-site loop [active]
490759001314	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
490759001315	Isochorismatase family; Region: Isochorismatase; pfam00857
490759001316	catalytic triad [active]
490759001317	metal binding site [ion binding]; metal-binding site
490759001318	conserved cis-peptide bond; other site
490759001319	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
490759001320	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
490759001321	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
490759001322	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
490759001323	ANTAR domain; Region: ANTAR; pfam03861
490759001324	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
490759001325	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759001326	dimer interface [polypeptide binding]; other site
490759001327	conserved gate region; other site
490759001328	putative PBP binding loops; other site
490759001329	ABC-ATPase subunit interface; other site
490759001330	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
490759001331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759001332	dimer interface [polypeptide binding]; other site
490759001333	conserved gate region; other site
490759001334	ABC-ATPase subunit interface; other site
490759001335	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
490759001336	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
490759001337	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
490759001338	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
490759001339	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
490759001340	Walker A/P-loop; other site
490759001341	ATP binding site [chemical binding]; other site
490759001342	Q-loop/lid; other site
490759001343	ABC transporter signature motif; other site
490759001344	Walker B; other site
490759001345	D-loop; other site
490759001346	H-loop/switch region; other site
490759001347	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
490759001348	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
490759001349	Walker A/P-loop; other site
490759001350	ATP binding site [chemical binding]; other site
490759001351	Q-loop/lid; other site
490759001352	ABC transporter signature motif; other site
490759001353	Walker B; other site
490759001354	D-loop; other site
490759001355	H-loop/switch region; other site
490759001356	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
490759001357	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
490759001358	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759001359	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
490759001360	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
490759001361	DctM-like transporters; Region: DctM; pfam06808
490759001362	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
490759001363	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759001364	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
490759001365	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
490759001366	active site
490759001367	V4R domain; Region: V4R; cl15268
490759001368	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
490759001369	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
490759001370	putative active site [active]
490759001371	putative FMN binding site [chemical binding]; other site
490759001372	putative substrate binding site [chemical binding]; other site
490759001373	putative catalytic residue [active]
490759001374	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
490759001375	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
490759001376	Cysteine-rich domain; Region: CCG; pfam02754
490759001377	Cysteine-rich domain; Region: CCG; pfam02754
490759001378	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
490759001379	Electron transfer flavoprotein domain; Region: ETF; smart00893
490759001380	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
490759001381	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
490759001382	Electron transfer flavoprotein domain; Region: ETF; pfam01012
490759001383	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
490759001384	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
490759001385	[2Fe-2S] cluster binding site [ion binding]; other site
490759001386	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
490759001387	putative alpha subunit interface [polypeptide binding]; other site
490759001388	putative active site [active]
490759001389	putative substrate binding site [chemical binding]; other site
490759001390	Fe binding site [ion binding]; other site
490759001391	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
490759001392	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
490759001393	FAD binding pocket [chemical binding]; other site
490759001394	FAD binding motif [chemical binding]; other site
490759001395	phosphate binding motif [ion binding]; other site
490759001396	beta-alpha-beta structure motif; other site
490759001397	NAD binding pocket [chemical binding]; other site
490759001398	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
490759001399	catalytic loop [active]
490759001400	iron binding site [ion binding]; other site
490759001401	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
490759001402	hydroxyglutarate oxidase; Provisional; Region: PRK11728
490759001403	hydroxyglutarate oxidase; Provisional; Region: PRK11728
490759001404	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
490759001405	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
490759001406	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
490759001407	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
490759001408	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
490759001409	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
490759001410	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
490759001411	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
490759001412	NAD binding site [chemical binding]; other site
490759001413	catalytic Zn binding site [ion binding]; other site
490759001414	structural Zn binding site [ion binding]; other site
490759001415	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
490759001416	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
490759001417	conserved cys residue [active]
490759001418	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
490759001419	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
490759001420	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
490759001421	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
490759001422	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
490759001423	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
490759001424	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
490759001425	putative active site [active]
490759001426	putative substrate binding site [chemical binding]; other site
490759001427	putative cosubstrate binding site; other site
490759001428	catalytic site [active]
490759001429	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
490759001430	active site
490759001431	catalytic residues [active]
490759001432	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
490759001433	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
490759001434	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
490759001435	active site
490759001436	DNA binding site [nucleotide binding]
490759001437	Int/Topo IB signature motif; other site
490759001438	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759001439	PAS fold; Region: PAS_3; pfam08447
490759001440	putative active site [active]
490759001441	heme pocket [chemical binding]; other site
490759001442	Protein of unknown function DUF45; Region: DUF45; pfam01863
490759001443	YaeQ protein; Region: YaeQ; pfam07152
490759001444	LrgB-like family; Region: LrgB; pfam04172
490759001445	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
490759001446	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
490759001447	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
490759001448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759001449	dimer interface [polypeptide binding]; other site
490759001450	conserved gate region; other site
490759001451	putative PBP binding loops; other site
490759001452	ABC-ATPase subunit interface; other site
490759001453	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
490759001454	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
490759001455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759001456	dimer interface [polypeptide binding]; other site
490759001457	conserved gate region; other site
490759001458	putative PBP binding loops; other site
490759001459	ABC-ATPase subunit interface; other site
490759001460	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
490759001461	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
490759001462	Walker A/P-loop; other site
490759001463	ATP binding site [chemical binding]; other site
490759001464	Q-loop/lid; other site
490759001465	ABC transporter signature motif; other site
490759001466	Walker B; other site
490759001467	D-loop; other site
490759001468	H-loop/switch region; other site
490759001469	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
490759001470	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
490759001471	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
490759001472	Walker A/P-loop; other site
490759001473	ATP binding site [chemical binding]; other site
490759001474	Q-loop/lid; other site
490759001475	ABC transporter signature motif; other site
490759001476	Walker B; other site
490759001477	D-loop; other site
490759001478	H-loop/switch region; other site
490759001479	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
490759001480	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759001481	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759001482	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759001483	proline dipeptidase; Provisional; Region: PRK13607
490759001484	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
490759001485	active site
490759001486	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
490759001487	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
490759001488	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
490759001489	heme binding site [chemical binding]; other site
490759001490	ferroxidase pore; other site
490759001491	ferroxidase diiron center [ion binding]; other site
490759001492	phosphomannomutase CpsG; Provisional; Region: PRK15414
490759001493	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
490759001494	active site
490759001495	substrate binding site [chemical binding]; other site
490759001496	metal binding site [ion binding]; metal-binding site
490759001497	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
490759001498	substrate binding site [chemical binding]; other site
490759001499	dimerization interface [polypeptide binding]; other site
490759001500	active site
490759001501	calcium binding site [ion binding]; other site
490759001502	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
490759001503	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
490759001504	Part of AAA domain; Region: AAA_19; pfam13245
490759001505	Family description; Region: UvrD_C_2; pfam13538
490759001506	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759001507	metal binding site [ion binding]; metal-binding site
490759001508	active site
490759001509	I-site; other site
490759001510	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759001511	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
490759001512	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
490759001513	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
490759001514	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
490759001515	RNA binding site [nucleotide binding]; other site
490759001516	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
490759001517	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
490759001518	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
490759001519	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; pfam04353
490759001520	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
490759001521	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
490759001522	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
490759001523	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
490759001524	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
490759001525	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
490759001526	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
490759001527	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
490759001528	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
490759001529	ABC transporter; Region: ABC_tran_2; pfam12848
490759001530	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
490759001531	exopolyphosphatase; Provisional; Region: PRK10854
490759001532	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
490759001533	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
490759001534	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
490759001535	catalytic residues [active]
490759001536	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
490759001537	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
490759001538	GTP binding site; other site
490759001539	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
490759001540	MoaE homodimer interface [polypeptide binding]; other site
490759001541	MoaD interaction [polypeptide binding]; other site
490759001542	active site residues [active]
490759001543	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
490759001544	MoaE interaction surface [polypeptide binding]; other site
490759001545	MoeB interaction surface [polypeptide binding]; other site
490759001546	thiocarboxylated glycine; other site
490759001547	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
490759001548	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
490759001549	dimer interface [polypeptide binding]; other site
490759001550	putative functional site; other site
490759001551	putative MPT binding site; other site
490759001552	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
490759001553	MPT binding site; other site
490759001554	trimer interface [polypeptide binding]; other site
490759001555	transcription termination factor Rho; Provisional; Region: rho; PRK09376
490759001556	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
490759001557	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
490759001558	RNA binding site [nucleotide binding]; other site
490759001559	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
490759001560	multimer interface [polypeptide binding]; other site
490759001561	Walker A motif; other site
490759001562	ATP binding site [chemical binding]; other site
490759001563	Walker B motif; other site
490759001564	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
490759001565	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
490759001566	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
490759001567	catalytic loop [active]
490759001568	iron binding site [ion binding]; other site
490759001569	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
490759001570	FAD binding pocket [chemical binding]; other site
490759001571	FAD binding motif [chemical binding]; other site
490759001572	phosphate binding motif [ion binding]; other site
490759001573	beta-alpha-beta structure motif; other site
490759001574	NAD binding pocket [chemical binding]; other site
490759001575	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
490759001576	HemY protein N-terminus; Region: HemY_N; pfam07219
490759001577	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
490759001578	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
490759001579	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
490759001580	active site
490759001581	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
490759001582	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
490759001583	domain interfaces; other site
490759001584	active site
490759001585	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
490759001586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759001587	active site
490759001588	phosphorylation site [posttranslational modification]
490759001589	intermolecular recognition site; other site
490759001590	dimerization interface [polypeptide binding]; other site
490759001591	LytTr DNA-binding domain; Region: LytTR; smart00850
490759001592	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
490759001593	Histidine kinase; Region: His_kinase; pfam06580
490759001594	argininosuccinate lyase; Provisional; Region: PRK00855
490759001595	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
490759001596	active sites [active]
490759001597	tetramer interface [polypeptide binding]; other site
490759001598	diaminopimelate decarboxylase; Region: lysA; TIGR01048
490759001599	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
490759001600	active site
490759001601	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
490759001602	substrate binding site [chemical binding]; other site
490759001603	catalytic residues [active]
490759001604	dimer interface [polypeptide binding]; other site
490759001605	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
490759001606	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
490759001607	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
490759001608	Protein of unknown function, DUF484; Region: DUF484; cl17449
490759001609	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
490759001610	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
490759001611	active site
490759001612	DNA binding site [nucleotide binding]
490759001613	Int/Topo IB signature motif; other site
490759001614	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759001615	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759001616	metal binding site [ion binding]; metal-binding site
490759001617	active site
490759001618	I-site; other site
490759001619	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759001620	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759001621	substrate binding pocket [chemical binding]; other site
490759001622	membrane-bound complex binding site; other site
490759001623	hinge residues; other site
490759001624	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759001625	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759001626	substrate binding pocket [chemical binding]; other site
490759001627	membrane-bound complex binding site; other site
490759001628	hinge residues; other site
490759001629	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759001630	dimer interface [polypeptide binding]; other site
490759001631	phosphorylation site [posttranslational modification]
490759001632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759001633	ATP binding site [chemical binding]; other site
490759001634	Mg2+ binding site [ion binding]; other site
490759001635	G-X-G motif; other site
490759001636	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
490759001637	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
490759001638	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
490759001639	putative active site [active]
490759001640	catalytic site [active]
490759001641	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
490759001642	putative active site [active]
490759001643	catalytic site [active]
490759001644	acyl-CoA esterase; Provisional; Region: PRK10673
490759001645	PGAP1-like protein; Region: PGAP1; pfam07819
490759001646	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
490759001647	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
490759001648	putative NAD(P) binding site [chemical binding]; other site
490759001649	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
490759001650	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
490759001651	TrkA-N domain; Region: TrkA_N; pfam02254
490759001652	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
490759001653	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
490759001654	putative ATP binding site [chemical binding]; other site
490759001655	putative substrate interface [chemical binding]; other site
490759001656	C factor cell-cell signaling protein; Provisional; Region: PRK09009
490759001657	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
490759001658	NADP binding site [chemical binding]; other site
490759001659	homodimer interface [polypeptide binding]; other site
490759001660	active site
490759001661	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
490759001662	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
490759001663	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
490759001664	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
490759001665	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
490759001666	DNA binding residues [nucleotide binding]
490759001667	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
490759001668	Nitrogen regulatory protein P-II; Region: P-II; cl00412
490759001669	Nitrogen regulatory protein P-II; Region: P-II; smart00938
490759001670	Membrane fusogenic activity; Region: BMFP; pfam04380
490759001671	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
490759001672	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
490759001673	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
490759001674	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
490759001675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759001676	S-adenosylmethionine binding site [chemical binding]; other site
490759001677	HemN family oxidoreductase; Provisional; Region: PRK05660
490759001678	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
490759001679	FeS/SAM binding site; other site
490759001680	HemN C-terminal domain; Region: HemN_C; pfam06969
490759001681	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
490759001682	active site
490759001683	dimerization interface [polypeptide binding]; other site
490759001684	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
490759001685	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759001686	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
490759001687	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
490759001688	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
490759001689	Dynamin family; Region: Dynamin_N; pfam00350
490759001690	G1 box; other site
490759001691	GTP/Mg2+ binding site [chemical binding]; other site
490759001692	G2 box; other site
490759001693	Switch I region; other site
490759001694	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
490759001695	G3 box; other site
490759001696	Switch II region; other site
490759001697	GTP/Mg2+ binding site [chemical binding]; other site
490759001698	G4 box; other site
490759001699	G5 box; other site
490759001700	YGGT family; Region: YGGT; pfam02325
490759001701	YGGT family; Region: YGGT; pfam02325
490759001702	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
490759001703	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
490759001704	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
490759001705	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
490759001706	catalytic residue [active]
490759001707	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
490759001708	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
490759001709	Walker A motif; other site
490759001710	ATP binding site [chemical binding]; other site
490759001711	Walker B motif; other site
490759001712	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
490759001713	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
490759001714	Walker A motif; other site
490759001715	ATP binding site [chemical binding]; other site
490759001716	Walker B motif; other site
490759001717	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
490759001718	DNA polymerase I; Provisional; Region: PRK05755
490759001719	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
490759001720	active site
490759001721	metal binding site 1 [ion binding]; metal-binding site
490759001722	putative 5' ssDNA interaction site; other site
490759001723	metal binding site 3; metal-binding site
490759001724	metal binding site 2 [ion binding]; metal-binding site
490759001725	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
490759001726	putative DNA binding site [nucleotide binding]; other site
490759001727	putative metal binding site [ion binding]; other site
490759001728	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
490759001729	active site
490759001730	catalytic site [active]
490759001731	substrate binding site [chemical binding]; other site
490759001732	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
490759001733	active site
490759001734	DNA binding site [nucleotide binding]
490759001735	catalytic site [active]
490759001736	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
490759001737	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
490759001738	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
490759001739	active site
490759001740	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
490759001741	putative active site [active]
490759001742	putative catalytic site [active]
490759001743	putative DNA binding site [nucleotide binding]; other site
490759001744	putative phosphate binding site [ion binding]; other site
490759001745	metal binding site A [ion binding]; metal-binding site
490759001746	putative AP binding site [nucleotide binding]; other site
490759001747	putative metal binding site B [ion binding]; other site
490759001748	ribonuclease PH; Reviewed; Region: rph; PRK00173
490759001749	Ribonuclease PH; Region: RNase_PH_bact; cd11362
490759001750	hexamer interface [polypeptide binding]; other site
490759001751	active site
490759001752	hypothetical protein; Provisional; Region: PRK11820
490759001753	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
490759001754	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
490759001755	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
490759001756	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
490759001757	DNA photolyase; Region: DNA_photolyase; pfam00875
490759001758	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
490759001759	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
490759001760	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
490759001761	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
490759001762	catalytic site [active]
490759001763	G-X2-G-X-G-K; other site
490759001764	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
490759001765	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
490759001766	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
490759001767	Zn2+ binding site [ion binding]; other site
490759001768	Mg2+ binding site [ion binding]; other site
490759001769	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
490759001770	synthetase active site [active]
490759001771	NTP binding site [chemical binding]; other site
490759001772	metal binding site [ion binding]; metal-binding site
490759001773	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
490759001774	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
490759001775	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
490759001776	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
490759001777	putative NAD(P) binding site [chemical binding]; other site
490759001778	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759001779	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759001780	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
490759001781	dimerization interface [polypeptide binding]; other site
490759001782	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
490759001783	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
490759001784	generic binding surface II; other site
490759001785	ssDNA binding site; other site
490759001786	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
490759001787	ATP binding site [chemical binding]; other site
490759001788	putative Mg++ binding site [ion binding]; other site
490759001789	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759001790	nucleotide binding region [chemical binding]; other site
490759001791	ATP-binding site [chemical binding]; other site
490759001792	HDOD domain; Region: HDOD; pfam08668
490759001793	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
490759001794	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
490759001795	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
490759001796	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
490759001797	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
490759001798	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
490759001799	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
490759001800	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
490759001801	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
490759001802	DNA binding residues [nucleotide binding]
490759001803	DNA primase; Validated; Region: dnaG; PRK05667
490759001804	CHC2 zinc finger; Region: zf-CHC2; pfam01807
490759001805	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
490759001806	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
490759001807	active site
490759001808	metal binding site [ion binding]; metal-binding site
490759001809	interdomain interaction site; other site
490759001810	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
490759001811	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
490759001812	UGMP family protein; Validated; Region: PRK09604
490759001813	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
490759001814	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
490759001815	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
490759001816	active site
490759001817	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
490759001818	catalytic center binding site [active]
490759001819	ATP binding site [chemical binding]; other site
490759001820	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
490759001821	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
490759001822	active site
490759001823	dimer interface [polypeptide binding]; other site
490759001824	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
490759001825	dimer interface [polypeptide binding]; other site
490759001826	active site
490759001827	Pantoate-beta-alanine ligase; Region: PanC; cd00560
490759001828	pantoate--beta-alanine ligase; Region: panC; TIGR00018
490759001829	active site
490759001830	ATP-binding site [chemical binding]; other site
490759001831	pantoate-binding site; other site
490759001832	HXXH motif; other site
490759001833	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
490759001834	oligomerization interface [polypeptide binding]; other site
490759001835	active site
490759001836	metal binding site [ion binding]; metal-binding site
490759001837	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
490759001838	catalytic center binding site [active]
490759001839	ATP binding site [chemical binding]; other site
490759001840	poly(A) polymerase; Region: pcnB; TIGR01942
490759001841	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
490759001842	active site
490759001843	NTP binding site [chemical binding]; other site
490759001844	metal binding triad [ion binding]; metal-binding site
490759001845	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
490759001846	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
490759001847	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
490759001848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759001849	active site
490759001850	phosphorylation site [posttranslational modification]
490759001851	intermolecular recognition site; other site
490759001852	dimerization interface [polypeptide binding]; other site
490759001853	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759001854	Walker A motif; other site
490759001855	ATP binding site [chemical binding]; other site
490759001856	Walker B motif; other site
490759001857	arginine finger; other site
490759001858	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
490759001859	Na binding site [ion binding]; other site
490759001860	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
490759001861	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759001862	putative active site [active]
490759001863	heme pocket [chemical binding]; other site
490759001864	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759001865	dimer interface [polypeptide binding]; other site
490759001866	phosphorylation site [posttranslational modification]
490759001867	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759001868	ATP binding site [chemical binding]; other site
490759001869	Mg2+ binding site [ion binding]; other site
490759001870	G-X-G motif; other site
490759001871	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
490759001872	active site
490759001873	HIGH motif; other site
490759001874	nucleotide binding site [chemical binding]; other site
490759001875	KMSKS motif; other site
490759001876	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
490759001877	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
490759001878	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
490759001879	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
490759001880	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
490759001881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
490759001882	Predicted kinase [General function prediction only]; Region: COG0645
490759001883	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
490759001884	active site
490759001885	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
490759001886	Transglycosylase; Region: Transgly; pfam00912
490759001887	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
490759001888	Tetratricopeptide repeat; Region: TPR_12; pfam13424
490759001889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759001890	binding surface
490759001891	TPR motif; other site
490759001892	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
490759001893	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
490759001894	inhibitor-cofactor binding pocket; inhibition site
490759001895	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759001896	catalytic residue [active]
490759001897	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
490759001898	thiamine phosphate binding site [chemical binding]; other site
490759001899	active site
490759001900	pyrophosphate binding site [ion binding]; other site
490759001901	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
490759001902	substrate binding site [chemical binding]; other site
490759001903	dimer interface [polypeptide binding]; other site
490759001904	ATP binding site [chemical binding]; other site
490759001905	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
490759001906	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
490759001907	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
490759001908	Cl- selectivity filter; other site
490759001909	Cl- binding residues [ion binding]; other site
490759001910	pore gating glutamate residue; other site
490759001911	dimer interface [polypeptide binding]; other site
490759001912	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
490759001913	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
490759001914	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
490759001915	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
490759001916	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
490759001917	Peptidase family M23; Region: Peptidase_M23; pfam01551
490759001918	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
490759001919	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
490759001920	active site
490759001921	HIGH motif; other site
490759001922	dimer interface [polypeptide binding]; other site
490759001923	KMSKS motif; other site
490759001924	Biotin operon repressor [Transcription]; Region: BirA; COG1654
490759001925	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
490759001926	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
490759001927	Type III pantothenate kinase; Region: Pan_kinase; cl17198
490759001928	elongation factor Tu; Reviewed; Region: PRK00049
490759001929	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
490759001930	G1 box; other site
490759001931	GEF interaction site [polypeptide binding]; other site
490759001932	GTP/Mg2+ binding site [chemical binding]; other site
490759001933	Switch I region; other site
490759001934	G2 box; other site
490759001935	G3 box; other site
490759001936	Switch II region; other site
490759001937	G4 box; other site
490759001938	G5 box; other site
490759001939	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
490759001940	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
490759001941	Antibiotic Binding Site [chemical binding]; other site
490759001942	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
490759001943	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
490759001944	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
490759001945	putative homodimer interface [polypeptide binding]; other site
490759001946	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
490759001947	heterodimer interface [polypeptide binding]; other site
490759001948	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
490759001949	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
490759001950	23S rRNA interface [nucleotide binding]; other site
490759001951	L7/L12 interface [polypeptide binding]; other site
490759001952	putative thiostrepton binding site; other site
490759001953	L25 interface [polypeptide binding]; other site
490759001954	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
490759001955	mRNA/rRNA interface [nucleotide binding]; other site
490759001956	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
490759001957	23S rRNA interface [nucleotide binding]; other site
490759001958	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
490759001959	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
490759001960	peripheral dimer interface [polypeptide binding]; other site
490759001961	core dimer interface [polypeptide binding]; other site
490759001962	L10 interface [polypeptide binding]; other site
490759001963	L11 interface [polypeptide binding]; other site
490759001964	putative EF-Tu interaction site [polypeptide binding]; other site
490759001965	putative EF-G interaction site [polypeptide binding]; other site
490759001966	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
490759001967	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
490759001968	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
490759001969	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
490759001970	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
490759001971	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
490759001972	RPB3 interaction site [polypeptide binding]; other site
490759001973	RPB1 interaction site [polypeptide binding]; other site
490759001974	RPB11 interaction site [polypeptide binding]; other site
490759001975	RPB10 interaction site [polypeptide binding]; other site
490759001976	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
490759001977	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
490759001978	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
490759001979	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
490759001980	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
490759001981	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
490759001982	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
490759001983	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
490759001984	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
490759001985	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
490759001986	DNA binding site [nucleotide binding]
490759001987	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
490759001988	30S ribosomal protein S7; Validated; Region: PRK05302
490759001989	elongation factor G; Reviewed; Region: PRK00007
490759001990	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
490759001991	G1 box; other site
490759001992	putative GEF interaction site [polypeptide binding]; other site
490759001993	GTP/Mg2+ binding site [chemical binding]; other site
490759001994	Switch I region; other site
490759001995	G2 box; other site
490759001996	G3 box; other site
490759001997	Switch II region; other site
490759001998	G4 box; other site
490759001999	G5 box; other site
490759002000	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
490759002001	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
490759002002	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
490759002003	elongation factor Tu; Reviewed; Region: PRK00049
490759002004	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
490759002005	G1 box; other site
490759002006	GEF interaction site [polypeptide binding]; other site
490759002007	GTP/Mg2+ binding site [chemical binding]; other site
490759002008	Switch I region; other site
490759002009	G2 box; other site
490759002010	G3 box; other site
490759002011	Switch II region; other site
490759002012	G4 box; other site
490759002013	G5 box; other site
490759002014	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
490759002015	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
490759002016	Antibiotic Binding Site [chemical binding]; other site
490759002017	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
490759002018	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
490759002019	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
490759002020	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
490759002021	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
490759002022	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
490759002023	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
490759002024	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
490759002025	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
490759002026	protein-rRNA interface [nucleotide binding]; other site
490759002027	putative translocon binding site; other site
490759002028	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
490759002029	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
490759002030	G-X-X-G motif; other site
490759002031	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
490759002032	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
490759002033	23S rRNA interface [nucleotide binding]; other site
490759002034	5S rRNA interface [nucleotide binding]; other site
490759002035	putative antibiotic binding site [chemical binding]; other site
490759002036	L25 interface [polypeptide binding]; other site
490759002037	L27 interface [polypeptide binding]; other site
490759002038	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
490759002039	23S rRNA interface [nucleotide binding]; other site
490759002040	putative translocon interaction site; other site
490759002041	signal recognition particle (SRP54) interaction site; other site
490759002042	L23 interface [polypeptide binding]; other site
490759002043	trigger factor interaction site; other site
490759002044	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
490759002045	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
490759002046	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
490759002047	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
490759002048	RNA binding site [nucleotide binding]; other site
490759002049	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
490759002050	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
490759002051	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
490759002052	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
490759002053	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
490759002054	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
490759002055	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
490759002056	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
490759002057	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
490759002058	5S rRNA interface [nucleotide binding]; other site
490759002059	23S rRNA interface [nucleotide binding]; other site
490759002060	L5 interface [polypeptide binding]; other site
490759002061	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
490759002062	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
490759002063	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
490759002064	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
490759002065	23S rRNA binding site [nucleotide binding]; other site
490759002066	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
490759002067	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
490759002068	SecY translocase; Region: SecY; pfam00344
490759002069	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
490759002070	30S ribosomal protein S13; Region: bact_S13; TIGR03631
490759002071	30S ribosomal protein S11; Validated; Region: PRK05309
490759002072	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
490759002073	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
490759002074	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
490759002075	RNA binding surface [nucleotide binding]; other site
490759002076	DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027
490759002077	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
490759002078	alphaNTD - beta interaction site [polypeptide binding]; other site
490759002079	alphaNTD - beta' interaction site [polypeptide binding]; other site
490759002080	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
490759002081	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
490759002082	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
490759002083	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
490759002084	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
490759002085	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
490759002086	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759002087	Major Facilitator Superfamily; Region: MFS_1; pfam07690
490759002088	putative substrate translocation pore; other site
490759002089	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
490759002090	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
490759002091	dimer interface [polypeptide binding]; other site
490759002092	ssDNA binding site [nucleotide binding]; other site
490759002093	tetramer (dimer of dimers) interface [polypeptide binding]; other site
490759002094	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
490759002095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759002096	active site
490759002097	phosphorylation site [posttranslational modification]
490759002098	intermolecular recognition site; other site
490759002099	dimerization interface [polypeptide binding]; other site
490759002100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759002101	Walker A motif; other site
490759002102	ATP binding site [chemical binding]; other site
490759002103	Walker B motif; other site
490759002104	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
490759002105	arginine finger; other site
490759002106	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759002107	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
490759002108	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759002109	dimer interface [polypeptide binding]; other site
490759002110	phosphorylation site [posttranslational modification]
490759002111	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759002112	ATP binding site [chemical binding]; other site
490759002113	G-X-G motif; other site
490759002114	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
490759002115	glutamine synthetase; Provisional; Region: glnA; PRK09469
490759002116	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
490759002117	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
490759002118	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
490759002119	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
490759002120	G1 box; other site
490759002121	putative GEF interaction site [polypeptide binding]; other site
490759002122	GTP/Mg2+ binding site [chemical binding]; other site
490759002123	Switch I region; other site
490759002124	G2 box; other site
490759002125	G3 box; other site
490759002126	Switch II region; other site
490759002127	G4 box; other site
490759002128	G5 box; other site
490759002129	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
490759002130	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
490759002131	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
490759002132	TAP-like protein; Region: Abhydrolase_4; pfam08386
490759002133	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
490759002134	putative active site [active]
490759002135	dimerization interface [polypeptide binding]; other site
490759002136	putative tRNAtyr binding site [nucleotide binding]; other site
490759002137	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
490759002138	eyelet of channel; other site
490759002139	trimer interface [polypeptide binding]; other site
490759002140	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
490759002141	Protein of unknown function, DUF547; Region: DUF547; pfam04784
490759002142	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
490759002143	putative active site [active]
490759002144	putative metal binding residues [ion binding]; other site
490759002145	signature motif; other site
490759002146	putative triphosphate binding site [ion binding]; other site
490759002147	Ion channel; Region: Ion_trans_2; pfam07885
490759002148	TrkA-N domain; Region: TrkA_N; pfam02254
490759002149	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
490759002150	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
490759002151	metal binding triad; other site
490759002152	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
490759002153	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
490759002154	metal binding triad; other site
490759002155	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
490759002156	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
490759002157	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
490759002158	homodimer interface [polypeptide binding]; other site
490759002159	substrate-cofactor binding pocket; other site
490759002160	catalytic residue [active]
490759002161	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
490759002162	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
490759002163	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
490759002164	putative active site [active]
490759002165	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
490759002166	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
490759002167	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
490759002168	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
490759002169	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
490759002170	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
490759002171	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
490759002172	O-Antigen ligase; Region: Wzy_C; pfam04932
490759002173	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
490759002174	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
490759002175	putative metal binding site; other site
490759002176	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
490759002177	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
490759002178	putative acyl-acceptor binding pocket; other site
490759002179	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
490759002180	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
490759002181	Substrate binding site; other site
490759002182	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
490759002183	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
490759002184	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
490759002185	putative metal binding site; other site
490759002186	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
490759002187	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
490759002188	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
490759002189	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
490759002190	putative ADP-binding pocket [chemical binding]; other site
490759002191	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
490759002192	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
490759002193	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
490759002194	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
490759002195	putative acyl-acceptor binding pocket; other site
490759002196	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
490759002197	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
490759002198	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
490759002199	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
490759002200	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
490759002201	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
490759002202	dimer interface [polypeptide binding]; other site
490759002203	ADP-ribose binding site [chemical binding]; other site
490759002204	active site
490759002205	nudix motif; other site
490759002206	metal binding site [ion binding]; metal-binding site
490759002207	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
490759002208	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
490759002209	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
490759002210	active site
490759002211	metal binding site [ion binding]; metal-binding site
490759002212	hexamer interface [polypeptide binding]; other site
490759002213	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
490759002214	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
490759002215	THF binding site; other site
490759002216	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
490759002217	substrate binding site [chemical binding]; other site
490759002218	THF binding site; other site
490759002219	zinc-binding site [ion binding]; other site
490759002220	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759002221	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759002222	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
490759002223	putative dimerization interface [polypeptide binding]; other site
490759002224	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
490759002225	lipoyl attachment site [posttranslational modification]; other site
490759002226	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
490759002227	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
490759002228	putative RNA binding site [nucleotide binding]; other site
490759002229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759002230	S-adenosylmethionine binding site [chemical binding]; other site
490759002231	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
490759002232	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
490759002233	RNA pyrophosphohydrolase; Reviewed; Region: PRK00714
490759002234	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
490759002235	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
490759002236	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
490759002237	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
490759002238	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
490759002239	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
490759002240	nucleophile elbow; other site
490759002241	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
490759002242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759002243	Walker A motif; other site
490759002244	ATP binding site [chemical binding]; other site
490759002245	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
490759002246	Walker B motif; other site
490759002247	arginine finger; other site
490759002248	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
490759002249	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
490759002250	active site
490759002251	HslU subunit interaction site [polypeptide binding]; other site
490759002252	Sporulation related domain; Region: SPOR; pfam05036
490759002253	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
490759002254	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
490759002255	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
490759002256	active site
490759002257	HIGH motif; other site
490759002258	KMSK motif region; other site
490759002259	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
490759002260	tRNA binding surface [nucleotide binding]; other site
490759002261	anticodon binding site; other site
490759002262	primosome assembly protein PriA; Validated; Region: PRK05580
490759002263	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
490759002264	ATP binding site [chemical binding]; other site
490759002265	putative Mg++ binding site [ion binding]; other site
490759002266	helicase superfamily c-terminal domain; Region: HELICc; smart00490
490759002267	ATP-binding site [chemical binding]; other site
490759002268	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
490759002269	Malic enzyme, N-terminal domain; Region: malic; pfam00390
490759002270	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
490759002271	putative NAD(P) binding site [chemical binding]; other site
490759002272	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
490759002273	Transglycosylase; Region: Transgly; pfam00912
490759002274	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
490759002275	Competence protein A; Region: Competence_A; pfam11104
490759002276	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
490759002277	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
490759002278	Pilus assembly protein, PilO; Region: PilO; pfam04350
490759002279	Pilus assembly protein, PilP; Region: PilP; pfam04351
490759002280	AMIN domain; Region: AMIN; pfam11741
490759002281	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
490759002282	Secretin and TonB N terminus short domain; Region: STN; smart00965
490759002283	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
490759002284	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
490759002285	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
490759002286	Shikimate kinase; Region: SKI; pfam01202
490759002287	ADP binding site [chemical binding]; other site
490759002288	magnesium binding site [ion binding]; other site
490759002289	putative shikimate binding site; other site
490759002290	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
490759002291	active site
490759002292	dimer interface [polypeptide binding]; other site
490759002293	metal binding site [ion binding]; metal-binding site
490759002294	AAA ATPase domain; Region: AAA_16; pfam13191
490759002295	AAA domain; Region: AAA_22; pfam13401
490759002296	Sporulation related domain; Region: SPOR; pfam05036
490759002297	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
490759002298	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
490759002299	active site
490759002300	dimer interface [polypeptide binding]; other site
490759002301	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
490759002302	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
490759002303	active site
490759002304	FMN binding site [chemical binding]; other site
490759002305	substrate binding site [chemical binding]; other site
490759002306	3Fe-4S cluster binding site [ion binding]; other site
490759002307	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
490759002308	domain interface; other site
490759002309	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
490759002310	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
490759002311	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
490759002312	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759002313	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
490759002314	substrate binding site [chemical binding]; other site
490759002315	active site
490759002316	DNA repair protein RadA; Provisional; Region: PRK11823
490759002317	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
490759002318	Walker A motif; other site
490759002319	ATP binding site [chemical binding]; other site
490759002320	Walker B motif; other site
490759002321	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
490759002322	PilZ domain; Region: PilZ; pfam07238
490759002323	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
490759002324	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759002325	Walker A/P-loop; other site
490759002326	ATP binding site [chemical binding]; other site
490759002327	Q-loop/lid; other site
490759002328	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
490759002329	ABC transporter signature motif; other site
490759002330	Walker B; other site
490759002331	ABC transporter; Region: ABC_tran_2; pfam12848
490759002332	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
490759002333	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
490759002334	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
490759002335	dimer interface [polypeptide binding]; other site
490759002336	active site
490759002337	glycine-pyridoxal phosphate binding site [chemical binding]; other site
490759002338	folate binding site [chemical binding]; other site
490759002339	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
490759002340	ATP cone domain; Region: ATP-cone; pfam03477
490759002341	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
490759002342	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
490759002343	catalytic motif [active]
490759002344	Zn binding site [ion binding]; other site
490759002345	RibD C-terminal domain; Region: RibD_C; cl17279
490759002346	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
490759002347	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
490759002348	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
490759002349	dimerization interface [polypeptide binding]; other site
490759002350	active site
490759002351	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
490759002352	homopentamer interface [polypeptide binding]; other site
490759002353	active site
490759002354	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
490759002355	thiamine monophosphate kinase; Provisional; Region: PRK05731
490759002356	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
490759002357	ATP binding site [chemical binding]; other site
490759002358	dimerization interface [polypeptide binding]; other site
490759002359	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
490759002360	tetramer interfaces [polypeptide binding]; other site
490759002361	binuclear metal-binding site [ion binding]; other site
490759002362	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
490759002363	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
490759002364	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
490759002365	substrate binding pocket [chemical binding]; other site
490759002366	chain length determination region; other site
490759002367	substrate-Mg2+ binding site; other site
490759002368	catalytic residues [active]
490759002369	aspartate-rich region 1; other site
490759002370	active site lid residues [active]
490759002371	aspartate-rich region 2; other site
490759002372	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
490759002373	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
490759002374	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
490759002375	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
490759002376	GTP1/OBG; Region: GTP1_OBG; pfam01018
490759002377	Obg GTPase; Region: Obg; cd01898
490759002378	G1 box; other site
490759002379	GTP/Mg2+ binding site [chemical binding]; other site
490759002380	Switch I region; other site
490759002381	G2 box; other site
490759002382	G3 box; other site
490759002383	Switch II region; other site
490759002384	G4 box; other site
490759002385	G5 box; other site
490759002386	gamma-glutamyl kinase; Provisional; Region: PRK05429
490759002387	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
490759002388	nucleotide binding site [chemical binding]; other site
490759002389	homotetrameric interface [polypeptide binding]; other site
490759002390	putative phosphate binding site [ion binding]; other site
490759002391	putative allosteric binding site; other site
490759002392	PUA domain; Region: PUA; pfam01472
490759002393	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
490759002394	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
490759002395	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
490759002396	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
490759002397	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
490759002398	active site
490759002399	Riboflavin kinase; Region: Flavokinase; pfam01687
490759002400	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
490759002401	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
490759002402	active site
490759002403	HIGH motif; other site
490759002404	nucleotide binding site [chemical binding]; other site
490759002405	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
490759002406	active site
490759002407	KMSKS motif; other site
490759002408	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
490759002409	tRNA binding surface [nucleotide binding]; other site
490759002410	anticodon binding site; other site
490759002411	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
490759002412	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
490759002413	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
490759002414	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
490759002415	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
490759002416	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
490759002417	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
490759002418	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
490759002419	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
490759002420	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
490759002421	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
490759002422	Type II transport protein GspH; Region: GspH; pfam12019
490759002423	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
490759002424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759002425	active site
490759002426	phosphorylation site [posttranslational modification]
490759002427	intermolecular recognition site; other site
490759002428	dimerization interface [polypeptide binding]; other site
490759002429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759002430	Walker A motif; other site
490759002431	ATP binding site [chemical binding]; other site
490759002432	Walker B motif; other site
490759002433	arginine finger; other site
490759002434	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759002435	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
490759002436	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759002437	dimer interface [polypeptide binding]; other site
490759002438	phosphorylation site [posttranslational modification]
490759002439	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759002440	ATP binding site [chemical binding]; other site
490759002441	Mg2+ binding site [ion binding]; other site
490759002442	G-X-G motif; other site
490759002443	NAD synthetase; Provisional; Region: PRK13981
490759002444	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
490759002445	multimer interface [polypeptide binding]; other site
490759002446	active site
490759002447	catalytic triad [active]
490759002448	protein interface 1 [polypeptide binding]; other site
490759002449	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
490759002450	homodimer interface [polypeptide binding]; other site
490759002451	NAD binding pocket [chemical binding]; other site
490759002452	ATP binding pocket [chemical binding]; other site
490759002453	Mg binding site [ion binding]; other site
490759002454	active-site loop [active]
490759002455	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
490759002456	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
490759002457	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
490759002458	RNA binding surface [nucleotide binding]; other site
490759002459	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
490759002460	active site
490759002461	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
490759002462	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
490759002463	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
490759002464	Clp amino terminal domain; Region: Clp_N; pfam02861
490759002465	Clp amino terminal domain; Region: Clp_N; pfam02861
490759002466	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759002467	Walker A motif; other site
490759002468	ATP binding site [chemical binding]; other site
490759002469	Walker B motif; other site
490759002470	arginine finger; other site
490759002471	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759002472	Walker A motif; other site
490759002473	ATP binding site [chemical binding]; other site
490759002474	Walker B motif; other site
490759002475	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
490759002476	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
490759002477	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
490759002478	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
490759002479	PYR/PP interface [polypeptide binding]; other site
490759002480	dimer interface [polypeptide binding]; other site
490759002481	TPP binding site [chemical binding]; other site
490759002482	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
490759002483	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
490759002484	TPP-binding site [chemical binding]; other site
490759002485	dimer interface [polypeptide binding]; other site
490759002486	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
490759002487	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
490759002488	putative valine binding site [chemical binding]; other site
490759002489	dimer interface [polypeptide binding]; other site
490759002490	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
490759002491	ketol-acid reductoisomerase; Provisional; Region: PRK05479
490759002492	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
490759002493	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
490759002494	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
490759002495	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
490759002496	2-isopropylmalate synthase; Validated; Region: PRK00915
490759002497	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
490759002498	active site
490759002499	catalytic residues [active]
490759002500	metal binding site [ion binding]; metal-binding site
490759002501	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
490759002502	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
490759002503	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
490759002504	Coenzyme A binding pocket [chemical binding]; other site
490759002505	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
490759002506	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
490759002507	G1 box; other site
490759002508	putative GEF interaction site [polypeptide binding]; other site
490759002509	GTP/Mg2+ binding site [chemical binding]; other site
490759002510	Switch I region; other site
490759002511	G2 box; other site
490759002512	G3 box; other site
490759002513	Switch II region; other site
490759002514	G4 box; other site
490759002515	G5 box; other site
490759002516	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
490759002517	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
490759002518	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
490759002519	active site
490759002520	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
490759002521	23S rRNA interface [nucleotide binding]; other site
490759002522	L3 interface [polypeptide binding]; other site
490759002523	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
490759002524	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
490759002525	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
490759002526	[2Fe-2S] cluster binding site [ion binding]; other site
490759002527	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
490759002528	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
490759002529	Qi binding site; other site
490759002530	intrachain domain interface; other site
490759002531	interchain domain interface [polypeptide binding]; other site
490759002532	heme bH binding site [chemical binding]; other site
490759002533	heme bL binding site [chemical binding]; other site
490759002534	Qo binding site; other site
490759002535	interchain domain interface [polypeptide binding]; other site
490759002536	intrachain domain interface; other site
490759002537	Qi binding site; other site
490759002538	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
490759002539	Qo binding site; other site
490759002540	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
490759002541	stringent starvation protein A; Provisional; Region: sspA; PRK09481
490759002542	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
490759002543	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
490759002544	dimer interface [polypeptide binding]; other site
490759002545	N-terminal domain interface [polypeptide binding]; other site
490759002546	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
490759002547	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
490759002548	dimer interface [polypeptide binding]; other site
490759002549	active site
490759002550	hypothetical protein; Reviewed; Region: PRK12497
490759002551	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
490759002552	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
490759002553	putative ligand binding site [chemical binding]; other site
490759002554	Predicted methyltransferases [General function prediction only]; Region: COG0313
490759002555	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
490759002556	putative SAM binding site [chemical binding]; other site
490759002557	putative homodimer interface [polypeptide binding]; other site
490759002558	cell division protein MraZ; Reviewed; Region: PRK00326
490759002559	MraZ protein; Region: MraZ; pfam02381
490759002560	MraZ protein; Region: MraZ; pfam02381
490759002561	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
490759002562	MraW methylase family; Region: Methyltransf_5; cl17771
490759002563	Cell division protein FtsL; Region: FtsL; pfam04999
490759002564	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
490759002565	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
490759002566	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
490759002567	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
490759002568	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
490759002569	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
490759002570	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
490759002571	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
490759002572	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
490759002573	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
490759002574	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
490759002575	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
490759002576	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
490759002577	Mg++ binding site [ion binding]; other site
490759002578	putative catalytic motif [active]
490759002579	putative substrate binding site [chemical binding]; other site
490759002580	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
490759002581	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
490759002582	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
490759002583	cell division protein FtsW; Region: ftsW; TIGR02614
490759002584	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
490759002585	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
490759002586	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
490759002587	active site
490759002588	homodimer interface [polypeptide binding]; other site
490759002589	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
490759002590	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
490759002591	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
490759002592	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
490759002593	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
490759002594	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
490759002595	ATP-grasp domain; Region: ATP-grasp_4; cl17255
490759002596	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
490759002597	Cell division protein FtsQ; Region: FtsQ; pfam03799
490759002598	cell division protein FtsA; Region: ftsA; TIGR01174
490759002599	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
490759002600	nucleotide binding site [chemical binding]; other site
490759002601	Cell division protein FtsA; Region: FtsA; pfam14450
490759002602	cell division protein FtsZ; Validated; Region: PRK09330
490759002603	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
490759002604	nucleotide binding site [chemical binding]; other site
490759002605	SulA interaction site; other site
490759002606	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
490759002607	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
490759002608	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
490759002609	Protein of unknown function (DUF721); Region: DUF721; pfam05258
490759002610	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
490759002611	Peptidase family M23; Region: Peptidase_M23; pfam01551
490759002612	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
490759002613	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
490759002614	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759002615	nucleotide binding region [chemical binding]; other site
490759002616	ATP-binding site [chemical binding]; other site
490759002617	SEC-C motif; Region: SEC-C; pfam02810
490759002618	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
490759002619	heterotetramer interface [polypeptide binding]; other site
490759002620	active site pocket [active]
490759002621	cleavage site
490759002622	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
490759002623	hypothetical protein; Provisional; Region: PRK08999
490759002624	active site
490759002625	8-oxo-dGMP binding site [chemical binding]; other site
490759002626	nudix motif; other site
490759002627	metal binding site [ion binding]; metal-binding site
490759002628	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
490759002629	active site
490759002630	thiamine phosphate binding site [chemical binding]; other site
490759002631	pyrophosphate binding site [ion binding]; other site
490759002632	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
490759002633	trimer interface [polypeptide binding]; other site
490759002634	dimer interface [polypeptide binding]; other site
490759002635	putative active site [active]
490759002636	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
490759002637	dimerization interface [polypeptide binding]; other site
490759002638	active site
490759002639	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
490759002640	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
490759002641	TPP-binding site; other site
490759002642	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
490759002643	PYR/PP interface [polypeptide binding]; other site
490759002644	dimer interface [polypeptide binding]; other site
490759002645	TPP binding site [chemical binding]; other site
490759002646	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
490759002647	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
490759002648	NRDE protein; Region: NRDE; cl01315
490759002649	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
490759002650	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
490759002651	thymidylate synthase; Reviewed; Region: thyA; PRK01827
490759002652	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
490759002653	dimerization interface [polypeptide binding]; other site
490759002654	active site
490759002655	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
490759002656	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
490759002657	folate binding site [chemical binding]; other site
490759002658	NADP+ binding site [chemical binding]; other site
490759002659	helicase 45; Provisional; Region: PTZ00424
490759002660	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
490759002661	ATP binding site [chemical binding]; other site
490759002662	Mg++ binding site [ion binding]; other site
490759002663	motif III; other site
490759002664	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759002665	nucleotide binding region [chemical binding]; other site
490759002666	ATP-binding site [chemical binding]; other site
490759002667	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
490759002668	Domain of unknown function DUF20; Region: UPF0118; pfam01594
490759002669	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
490759002670	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
490759002671	ligand binding site [chemical binding]; other site
490759002672	flexible hinge region; other site
490759002673	HDOD domain; Region: HDOD; pfam08668
490759002674	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
490759002675	Zn2+ binding site [ion binding]; other site
490759002676	Mg2+ binding site [ion binding]; other site
490759002677	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
490759002678	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
490759002679	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
490759002680	active site
490759002681	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759002682	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759002683	metal binding site [ion binding]; metal-binding site
490759002684	active site
490759002685	I-site; other site
490759002686	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759002687	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759002688	metal binding site [ion binding]; metal-binding site
490759002689	active site
490759002690	I-site; other site
490759002691	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
490759002692	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
490759002693	putative catalytic cysteine [active]
490759002694	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
490759002695	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
490759002696	active site
490759002697	(T/H)XGH motif; other site
490759002698	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
490759002699	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
490759002700	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
490759002701	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
490759002702	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
490759002703	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
490759002704	rare lipoprotein A; Provisional; Region: PRK10672
490759002705	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
490759002706	Sporulation related domain; Region: SPOR; pfam05036
490759002707	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
490759002708	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
490759002709	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
490759002710	Protein of unknown function (DUF493); Region: DUF493; pfam04359
490759002711	lipoate-protein ligase B; Provisional; Region: PRK14342
490759002712	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
490759002713	ABC1 family; Region: ABC1; cl17513
490759002714	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
490759002715	GSH binding site [chemical binding]; other site
490759002716	catalytic residues [active]
490759002717	EAL domain; Region: EAL; pfam00563
490759002718	6-phosphofructokinase; Provisional; Region: PRK14072
490759002719	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
490759002720	active site
490759002721	ADP/pyrophosphate binding site [chemical binding]; other site
490759002722	dimerization interface [polypeptide binding]; other site
490759002723	allosteric effector site; other site
490759002724	fructose-1,6-bisphosphate binding site; other site
490759002725	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
490759002726	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
490759002727	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
490759002728	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
490759002729	aromatic acid decarboxylase; Validated; Region: PRK05920
490759002730	Flavoprotein; Region: Flavoprotein; pfam02441
490759002731	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
490759002732	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
490759002733	putative NAD(P) binding site [chemical binding]; other site
490759002734	putative substrate binding site [chemical binding]; other site
490759002735	catalytic Zn binding site [ion binding]; other site
490759002736	structural Zn binding site [ion binding]; other site
490759002737	dimer interface [polypeptide binding]; other site
490759002738	ribonuclease R; Region: RNase_R; TIGR02063
490759002739	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
490759002740	RNB domain; Region: RNB; pfam00773
490759002741	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
490759002742	RNA binding site [nucleotide binding]; other site
490759002743	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
490759002744	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
490759002745	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
490759002746	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
490759002747	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
490759002748	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
490759002749	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
490759002750	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
490759002751	replicative DNA helicase; Provisional; Region: PRK05748
490759002752	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
490759002753	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
490759002754	Walker A motif; other site
490759002755	ATP binding site [chemical binding]; other site
490759002756	Walker B motif; other site
490759002757	DNA binding loops [nucleotide binding]
490759002758	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
490759002759	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
490759002760	active site
490759002761	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
490759002762	substrate binding site [chemical binding]; other site
490759002763	catalytic residues [active]
490759002764	dimer interface [polypeptide binding]; other site
490759002765	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
490759002766	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759002767	NAD(P) binding site [chemical binding]; other site
490759002768	active site
490759002769	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
490759002770	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
490759002771	ligand binding site [chemical binding]; other site
490759002772	flexible hinge region; other site
490759002773	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
490759002774	non-specific DNA interactions [nucleotide binding]; other site
490759002775	DNA binding site [nucleotide binding]
490759002776	sequence specific DNA binding site [nucleotide binding]; other site
490759002777	putative cAMP binding site [chemical binding]; other site
490759002778	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
490759002779	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
490759002780	dimer interface [polypeptide binding]; other site
490759002781	active site
490759002782	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
490759002783	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
490759002784	GTP/Mg2+ binding site [chemical binding]; other site
490759002785	G4 box; other site
490759002786	G5 box; other site
490759002787	G1 box; other site
490759002788	Switch I region; other site
490759002789	G2 box; other site
490759002790	G3 box; other site
490759002791	Switch II region; other site
490759002792	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
490759002793	dimer interface [polypeptide binding]; other site
490759002794	lipoyl synthase; Provisional; Region: PRK05481
490759002795	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
490759002796	FeS/SAM binding site; other site
490759002797	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
490759002798	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
490759002799	homodimer interface [polypeptide binding]; other site
490759002800	substrate-cofactor binding pocket; other site
490759002801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759002802	catalytic residue [active]
490759002803	Predicted membrane protein [Function unknown]; Region: COG2860
490759002804	UPF0126 domain; Region: UPF0126; pfam03458
490759002805	UPF0126 domain; Region: UPF0126; pfam03458
490759002806	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
490759002807	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
490759002808	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759002809	S-adenosylmethionine binding site [chemical binding]; other site
490759002810	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759002811	PAS domain; Region: PAS_9; pfam13426
490759002812	putative active site [active]
490759002813	heme pocket [chemical binding]; other site
490759002814	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759002815	PAS domain; Region: PAS_9; pfam13426
490759002816	putative active site [active]
490759002817	heme pocket [chemical binding]; other site
490759002818	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759002819	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759002820	metal binding site [ion binding]; metal-binding site
490759002821	active site
490759002822	I-site; other site
490759002823	PAS domain S-box; Region: sensory_box; TIGR00229
490759002824	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759002825	putative active site [active]
490759002826	heme pocket [chemical binding]; other site
490759002827	PAS domain S-box; Region: sensory_box; TIGR00229
490759002828	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759002829	putative active site [active]
490759002830	heme pocket [chemical binding]; other site
490759002831	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759002832	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759002833	metal binding site [ion binding]; metal-binding site
490759002834	active site
490759002835	I-site; other site
490759002836	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759002837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759002838	putative active site [active]
490759002839	heme pocket [chemical binding]; other site
490759002840	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
490759002841	active site
490759002842	homotetramer interface [polypeptide binding]; other site
490759002843	homodimer interface [polypeptide binding]; other site
490759002844	Transcriptional regulators [Transcription]; Region: FadR; COG2186
490759002845	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759002846	DNA-binding site [nucleotide binding]; DNA binding site
490759002847	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
490759002848	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
490759002849	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
490759002850	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
490759002851	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
490759002852	active site
490759002853	catalytic site [active]
490759002854	tetramer interface [polypeptide binding]; other site
490759002855	hypothetical protein; Provisional; Region: PRK11171
490759002856	Cupin domain; Region: Cupin_2; pfam07883
490759002857	Cupin domain; Region: Cupin_2; pfam07883
490759002858	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115
490759002859	GTP-binding protein YchF; Reviewed; Region: PRK09601
490759002860	YchF GTPase; Region: YchF; cd01900
490759002861	G1 box; other site
490759002862	GTP/Mg2+ binding site [chemical binding]; other site
490759002863	Switch I region; other site
490759002864	G2 box; other site
490759002865	Switch II region; other site
490759002866	G3 box; other site
490759002867	G4 box; other site
490759002868	G5 box; other site
490759002869	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
490759002870	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
490759002871	putative active site [active]
490759002872	catalytic residue [active]
490759002873	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
490759002874	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
490759002875	5S rRNA interface [nucleotide binding]; other site
490759002876	CTC domain interface [polypeptide binding]; other site
490759002877	L16 interface [polypeptide binding]; other site
490759002878	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
490759002879	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
490759002880	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
490759002881	active site
490759002882	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
490759002883	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
490759002884	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
490759002885	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
490759002886	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759002887	binding surface
490759002888	TPR motif; other site
490759002889	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
490759002890	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
490759002891	tRNA; other site
490759002892	putative tRNA binding site [nucleotide binding]; other site
490759002893	putative NADP binding site [chemical binding]; other site
490759002894	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
490759002895	peptide chain release factor 1; Validated; Region: prfA; PRK00591
490759002896	This domain is found in peptide chain release factors; Region: PCRF; smart00937
490759002897	RF-1 domain; Region: RF-1; pfam00472
490759002898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
490759002899	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
490759002900	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
490759002901	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
490759002902	ATP binding site [chemical binding]; other site
490759002903	substrate interface [chemical binding]; other site
490759002904	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
490759002905	DNA photolyase; Region: DNA_photolyase; pfam00875
490759002906	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
490759002907	Mechanosensitive ion channel; Region: MS_channel; pfam00924
490759002908	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
490759002909	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
490759002910	RimK-like ATP-grasp domain; Region: RimK; pfam08443
490759002911	Predicted deacylase [General function prediction only]; Region: COG3608
490759002912	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
490759002913	putative active site [active]
490759002914	Zn binding site [ion binding]; other site
490759002915	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
490759002916	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
490759002917	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
490759002918	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
490759002919	DNA binding residues [nucleotide binding]
490759002920	dimerization interface [polypeptide binding]; other site
490759002921	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
490759002922	YfaZ precursor; Region: YfaZ; pfam07437
490759002923	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
490759002924	Domain of unknown function (DUF329); Region: DUF329; pfam03884
490759002925	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
490759002926	homodimer interaction site [polypeptide binding]; other site
490759002927	cofactor binding site; other site
490759002928	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
490759002929	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
490759002930	CoA-binding site [chemical binding]; other site
490759002931	ATP-binding [chemical binding]; other site
490759002932	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
490759002933	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
490759002934	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
490759002935	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
490759002936	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
490759002937	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
490759002938	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
490759002939	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
490759002940	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
490759002941	Walker A motif; other site
490759002942	ATP binding site [chemical binding]; other site
490759002943	Walker B motif; other site
490759002944	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
490759002945	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
490759002946	Pilin (bacterial filament); Region: Pilin; pfam00114
490759002947	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
490759002948	Sulfatase; Region: Sulfatase; cl17466
490759002949	Beta-lactamase; Region: Beta-lactamase; pfam00144
490759002950	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
490759002951	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
490759002952	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
490759002953	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
490759002954	catalytic core [active]
490759002955	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
490759002956	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
490759002957	P-loop; other site
490759002958	Magnesium ion binding site [ion binding]; other site
490759002959	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
490759002960	Magnesium ion binding site [ion binding]; other site
490759002961	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
490759002962	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
490759002963	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759002964	active site
490759002965	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
490759002966	bile acid transporter; Region: bass; TIGR00841
490759002967	Sodium Bile acid symporter family; Region: SBF; cl17470
490759002968	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
490759002969	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
490759002970	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
490759002971	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
490759002972	C-terminal domain interface [polypeptide binding]; other site
490759002973	GSH binding site (G-site) [chemical binding]; other site
490759002974	dimer interface [polypeptide binding]; other site
490759002975	putative efflux protein, MATE family; Region: matE; TIGR00797
490759002976	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
490759002977	CHASE3 domain; Region: CHASE3; cl05000
490759002978	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
490759002979	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759002980	dimerization interface [polypeptide binding]; other site
490759002981	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759002982	dimer interface [polypeptide binding]; other site
490759002983	putative CheW interface [polypeptide binding]; other site
490759002984	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
490759002985	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
490759002986	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
490759002987	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
490759002988	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
490759002989	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
490759002990	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
490759002991	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
490759002992	dimer interface [polypeptide binding]; other site
490759002993	active site
490759002994	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
490759002995	catalytic residues [active]
490759002996	substrate binding site [chemical binding]; other site
490759002997	Cache domain; Region: Cache_1; pfam02743
490759002998	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759002999	dimerization interface [polypeptide binding]; other site
490759003000	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
490759003001	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759003002	dimer interface [polypeptide binding]; other site
490759003003	putative CheW interface [polypeptide binding]; other site
490759003004	Class I aldolases; Region: Aldolase_Class_I; cl17187
490759003005	catalytic residue [active]
490759003006	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
490759003007	Mechanosensitive ion channel; Region: MS_channel; pfam00924
490759003008	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
490759003009	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
490759003010	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
490759003011	NAD(P) binding site [chemical binding]; other site
490759003012	catalytic residues [active]
490759003013	CHASE3 domain; Region: CHASE3; pfam05227
490759003014	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
490759003015	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
490759003016	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759003017	dimer interface [polypeptide binding]; other site
490759003018	putative CheW interface [polypeptide binding]; other site
490759003019	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
490759003020	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
490759003021	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
490759003022	transmembrane helices; other site
490759003023	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
490759003024	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
490759003025	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
490759003026	putative active site [active]
490759003027	PhoH-like protein; Region: PhoH; pfam02562
490759003028	FOG: CBS domain [General function prediction only]; Region: COG0517
490759003029	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
490759003030	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
490759003031	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
490759003032	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
490759003033	Switch I; other site
490759003034	Switch II; other site
490759003035	septum formation inhibitor; Reviewed; Region: minC; PRK00339
490759003036	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
490759003037	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
490759003038	Protein of unknown function (DUF1244); Region: DUF1244; cl01385
490759003039	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
490759003040	active site
490759003041	DNA polymerase IV; Validated; Region: PRK02406
490759003042	DNA binding site [nucleotide binding]
490759003043	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
490759003044	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
490759003045	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
490759003046	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
490759003047	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
490759003048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759003049	active site
490759003050	phosphorylation site [posttranslational modification]
490759003051	intermolecular recognition site; other site
490759003052	dimerization interface [polypeptide binding]; other site
490759003053	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
490759003054	DNA binding site [nucleotide binding]
490759003055	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759003056	dimerization interface [polypeptide binding]; other site
490759003057	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759003058	dimer interface [polypeptide binding]; other site
490759003059	phosphorylation site [posttranslational modification]
490759003060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759003061	ATP binding site [chemical binding]; other site
490759003062	Mg2+ binding site [ion binding]; other site
490759003063	G-X-G motif; other site
490759003064	ornithine carbamoyltransferase; Provisional; Region: PRK00779
490759003065	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
490759003066	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
490759003067	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
490759003068	putative GSH binding site [chemical binding]; other site
490759003069	catalytic residues [active]
490759003070	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
490759003071	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
490759003072	Domain of unknown function DUF21; Region: DUF21; pfam01595
490759003073	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
490759003074	Transporter associated domain; Region: CorC_HlyC; smart01091
490759003075	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
490759003076	signal recognition particle protein; Provisional; Region: PRK10867
490759003077	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
490759003078	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
490759003079	P loop; other site
490759003080	GTP binding site [chemical binding]; other site
490759003081	Signal peptide binding domain; Region: SRP_SPB; pfam02978
490759003082	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
490759003083	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
490759003084	RimM N-terminal domain; Region: RimM; pfam01782
490759003085	PRC-barrel domain; Region: PRC; pfam05239
490759003086	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
490759003087	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
490759003088	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
490759003089	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
490759003090	active site
490759003091	Int/Topo IB signature motif; other site
490759003092	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
490759003093	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
490759003094	dimerization domain [polypeptide binding]; other site
490759003095	dimer interface [polypeptide binding]; other site
490759003096	catalytic residues [active]
490759003097	homoserine dehydrogenase; Provisional; Region: PRK06349
490759003098	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
490759003099	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
490759003100	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
490759003101	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
490759003102	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
490759003103	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759003104	catalytic residue [active]
490759003105	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
490759003106	DHH family; Region: DHH; pfam01368
490759003107	DHHA1 domain; Region: DHHA1; pfam02272
490759003108	flagellin; Reviewed; Region: PRK08869
490759003109	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
490759003110	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
490759003111	flagellin; Reviewed; Region: PRK08869
490759003112	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
490759003113	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
490759003114	FlaG protein; Region: FlaG; pfam03646
490759003115	flagellar capping protein; Provisional; Region: PRK12765
490759003116	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
490759003117	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
490759003118	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
490759003119	flagellar protein FliS; Validated; Region: fliS; PRK05685
490759003120	argininosuccinate synthase; Provisional; Region: PRK13820
490759003121	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
490759003122	ANP binding site [chemical binding]; other site
490759003123	Substrate Binding Site II [chemical binding]; other site
490759003124	Substrate Binding Site I [chemical binding]; other site
490759003125	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
490759003126	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
490759003127	muropeptide transporter; Reviewed; Region: ampG; PRK11902
490759003128	muropeptide transporter; Validated; Region: ampG; cl17669
490759003129	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
490759003130	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
490759003131	active site
490759003132	DNA binding site [nucleotide binding]
490759003133	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
490759003134	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759003135	NAD(P) binding site [chemical binding]; other site
490759003136	active site
490759003137	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
490759003138	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
490759003139	oligomerisation interface [polypeptide binding]; other site
490759003140	mobile loop; other site
490759003141	roof hairpin; other site
490759003142	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
490759003143	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
490759003144	ring oligomerisation interface [polypeptide binding]; other site
490759003145	ATP/Mg binding site [chemical binding]; other site
490759003146	stacking interactions; other site
490759003147	hinge regions; other site
490759003148	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
490759003149	type II secretion system protein D; Region: type_II_gspD; TIGR02517
490759003150	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
490759003151	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
490759003152	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
490759003153	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
490759003154	Peptidase family M48; Region: Peptidase_M48; cl12018
490759003155	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
490759003156	superoxide dismutase; Provisional; Region: PRK10543
490759003157	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
490759003158	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
490759003159	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
490759003160	ATP-grasp domain; Region: ATP-grasp; pfam02222
490759003161	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
490759003162	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
490759003163	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
490759003164	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759003165	NAD(P) binding site [chemical binding]; other site
490759003166	active site
490759003167	SapC; Region: SapC; pfam07277
490759003168	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
490759003169	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
490759003170	Surface antigen; Region: Bac_surface_Ag; pfam01103
490759003171	GAF domain; Region: GAF; pfam01590
490759003172	PAS domain S-box; Region: sensory_box; TIGR00229
490759003173	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759003174	putative active site [active]
490759003175	heme pocket [chemical binding]; other site
490759003176	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759003177	PAS domain; Region: PAS_9; pfam13426
490759003178	putative active site [active]
490759003179	heme pocket [chemical binding]; other site
490759003180	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759003181	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759003182	metal binding site [ion binding]; metal-binding site
490759003183	active site
490759003184	I-site; other site
490759003185	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759003186	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
490759003187	Surface antigen; Region: Bac_surface_Ag; pfam01103
490759003188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
490759003189	Family of unknown function (DUF490); Region: DUF490; pfam04357
490759003190	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
490759003191	catalytic triad [active]
490759003192	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
490759003193	LexA repressor; Validated; Region: PRK00215
490759003194	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
490759003195	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
490759003196	Catalytic site [active]
490759003197	Cell division inhibitor SulA; Region: SulA; cl01880
490759003198	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
490759003199	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
490759003200	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759003201	Walker A motif; other site
490759003202	ATP binding site [chemical binding]; other site
490759003203	Walker B motif; other site
490759003204	arginine finger; other site
490759003205	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759003206	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
490759003207	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759003208	putative active site [active]
490759003209	heme pocket [chemical binding]; other site
490759003210	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759003211	dimer interface [polypeptide binding]; other site
490759003212	phosphorylation site [posttranslational modification]
490759003213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759003214	ATP binding site [chemical binding]; other site
490759003215	Mg2+ binding site [ion binding]; other site
490759003216	G-X-G motif; other site
490759003217	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
490759003218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759003219	active site
490759003220	phosphorylation site [posttranslational modification]
490759003221	intermolecular recognition site; other site
490759003222	dimerization interface [polypeptide binding]; other site
490759003223	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759003224	Walker A motif; other site
490759003225	ATP binding site [chemical binding]; other site
490759003226	Walker B motif; other site
490759003227	arginine finger; other site
490759003228	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759003229	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
490759003230	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
490759003231	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
490759003232	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
490759003233	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
490759003234	MgtE intracellular N domain; Region: MgtE_N; smart00924
490759003235	FliG C-terminal domain; Region: FliG_C; pfam01706
490759003236	flagellar assembly protein H; Validated; Region: fliH; PRK05687
490759003237	Flagellar assembly protein FliH; Region: FliH; pfam02108
490759003238	flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688
490759003239	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
490759003240	Walker A motif/ATP binding site; other site
490759003241	Walker B motif; other site
490759003242	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
490759003243	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
490759003244	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
490759003245	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
490759003246	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
490759003247	flagellar motor switch protein; Validated; Region: fliN; PRK05698
490759003248	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
490759003249	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
490759003250	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
490759003251	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
490759003252	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
490759003253	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
490759003254	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
490759003255	enoyl-CoA hydratase; Provisional; Region: PRK06688
490759003256	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759003257	substrate binding site [chemical binding]; other site
490759003258	oxyanion hole (OAH) forming residues; other site
490759003259	trimer interface [polypeptide binding]; other site
490759003260	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
490759003261	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
490759003262	CoA binding domain; Region: CoA_binding_2; pfam13380
490759003263	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
490759003264	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
490759003265	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
490759003266	enoyl-CoA hydratase; Provisional; Region: PRK09245
490759003267	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759003268	substrate binding site [chemical binding]; other site
490759003269	oxyanion hole (OAH) forming residues; other site
490759003270	trimer interface [polypeptide binding]; other site
490759003271	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
490759003272	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
490759003273	Cu(I) binding site [ion binding]; other site
490759003274	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
490759003275	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
490759003276	Multicopper oxidase; Region: Cu-oxidase; pfam00394
490759003277	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
490759003278	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
490759003279	active site
490759003280	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
490759003281	FHIPEP family; Region: FHIPEP; pfam00771
490759003282	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
490759003283	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759003284	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
490759003285	Walker A/P-loop; other site
490759003286	ATP binding site [chemical binding]; other site
490759003287	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
490759003288	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
490759003289	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
490759003290	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
490759003291	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
490759003292	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
490759003293	DNA binding residues [nucleotide binding]
490759003294	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
490759003295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759003296	active site
490759003297	phosphorylation site [posttranslational modification]
490759003298	intermolecular recognition site; other site
490759003299	dimerization interface [polypeptide binding]; other site
490759003300	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
490759003301	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
490759003302	putative binding surface; other site
490759003303	active site
490759003304	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
490759003305	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
490759003306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759003307	ATP binding site [chemical binding]; other site
490759003308	Mg2+ binding site [ion binding]; other site
490759003309	G-X-G motif; other site
490759003310	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
490759003311	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
490759003312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759003313	active site
490759003314	phosphorylation site [posttranslational modification]
490759003315	intermolecular recognition site; other site
490759003316	dimerization interface [polypeptide binding]; other site
490759003317	CheB methylesterase; Region: CheB_methylest; pfam01339
490759003318	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
490759003319	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
490759003320	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
490759003321	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
490759003322	ligand binding site [chemical binding]; other site
490759003323	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
490759003324	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
490759003325	P-loop; other site
490759003326	Magnesium ion binding site [ion binding]; other site
490759003327	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
490759003328	Magnesium ion binding site [ion binding]; other site
490759003329	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
490759003330	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
490759003331	putative CheA interaction surface; other site
490759003332	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
490759003333	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
490759003334	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
490759003335	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
490759003336	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759003337	Walker A/P-loop; other site
490759003338	ATP binding site [chemical binding]; other site
490759003339	Q-loop/lid; other site
490759003340	ABC transporter signature motif; other site
490759003341	Walker B; other site
490759003342	D-loop; other site
490759003343	H-loop/switch region; other site
490759003344	heme exporter protein CcmB; Region: ccmB; TIGR01190
490759003345	heme exporter protein CcmC; Region: ccmC; TIGR01191
490759003346	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
490759003347	CcmE; Region: CcmE; pfam03100
490759003348	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
490759003349	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
490759003350	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
490759003351	catalytic residues [active]
490759003352	central insert; other site
490759003353	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
490759003354	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
490759003355	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
490759003356	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759003357	binding surface
490759003358	TPR motif; other site
490759003359	Oxygen tolerance; Region: BatD; pfam13584
490759003360	von Willebrand factor type A domain; Region: VWA_2; pfam13519
490759003361	metal ion-dependent adhesion site (MIDAS); other site
490759003362	TPR repeat; Region: TPR_11; pfam13414
490759003363	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759003364	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
490759003365	metal ion-dependent adhesion site (MIDAS); other site
490759003366	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
490759003367	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
490759003368	Protein of unknown function DUF58; Region: DUF58; pfam01882
490759003369	MoxR-like ATPases [General function prediction only]; Region: COG0714
490759003370	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759003371	Walker A motif; other site
490759003372	ATP binding site [chemical binding]; other site
490759003373	Walker B motif; other site
490759003374	arginine finger; other site
490759003375	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
490759003376	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
490759003377	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
490759003378	active site clefts [active]
490759003379	zinc binding site [ion binding]; other site
490759003380	dimer interface [polypeptide binding]; other site
490759003381	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
490759003382	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
490759003383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759003384	S-adenosylmethionine binding site [chemical binding]; other site
490759003385	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
490759003386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759003387	S-adenosylmethionine binding site [chemical binding]; other site
490759003388	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
490759003389	Lumazine binding domain; Region: Lum_binding; pfam00677
490759003390	Lumazine binding domain; Region: Lum_binding; pfam00677
490759003391	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
490759003392	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
490759003393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
490759003394	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
490759003395	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
490759003396	Mechanosensitive ion channel; Region: MS_channel; pfam00924
490759003397	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
490759003398	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
490759003399	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
490759003400	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
490759003401	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
490759003402	ATP binding site [chemical binding]; other site
490759003403	putative Mg++ binding site [ion binding]; other site
490759003404	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759003405	nucleotide binding region [chemical binding]; other site
490759003406	ATP-binding site [chemical binding]; other site
490759003407	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
490759003408	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
490759003409	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
490759003410	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
490759003411	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
490759003412	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
490759003413	E3 interaction surface; other site
490759003414	lipoyl attachment site [posttranslational modification]; other site
490759003415	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
490759003416	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
490759003417	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
490759003418	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
490759003419	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
490759003420	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
490759003421	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
490759003422	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
490759003423	catalytic loop [active]
490759003424	iron binding site [ion binding]; other site
490759003425	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
490759003426	FAD binding pocket [chemical binding]; other site
490759003427	FAD binding motif [chemical binding]; other site
490759003428	phosphate binding motif [ion binding]; other site
490759003429	beta-alpha-beta structure motif; other site
490759003430	NAD binding pocket [chemical binding]; other site
490759003431	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
490759003432	ApbE family; Region: ApbE; pfam02424
490759003433	Protein of unknown function (DUF539); Region: DUF539; cl01129
490759003434	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
490759003435	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
490759003436	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759003437	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
490759003438	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
490759003439	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
490759003440	active site
490759003441	catalytic site [active]
490759003442	metal binding site [ion binding]; metal-binding site
490759003443	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
490759003444	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
490759003445	transaldolase-like protein; Provisional; Region: PTZ00411
490759003446	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
490759003447	active site
490759003448	dimer interface [polypeptide binding]; other site
490759003449	catalytic residue [active]
490759003450	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
490759003451	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
490759003452	FMN binding site [chemical binding]; other site
490759003453	active site
490759003454	catalytic residues [active]
490759003455	substrate binding site [chemical binding]; other site
490759003456	Hemerythrin family; Region: Hemerythrin-like; cl15774
490759003457	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
490759003458	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
490759003459	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
490759003460	Walker A/P-loop; other site
490759003461	ATP binding site [chemical binding]; other site
490759003462	Q-loop/lid; other site
490759003463	ABC transporter signature motif; other site
490759003464	Walker B; other site
490759003465	D-loop; other site
490759003466	H-loop/switch region; other site
490759003467	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
490759003468	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
490759003469	Walker A/P-loop; other site
490759003470	ATP binding site [chemical binding]; other site
490759003471	Q-loop/lid; other site
490759003472	ABC transporter signature motif; other site
490759003473	Walker B; other site
490759003474	D-loop; other site
490759003475	H-loop/switch region; other site
490759003476	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
490759003477	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
490759003478	putative ligand binding site [chemical binding]; other site
490759003479	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
490759003480	TM-ABC transporter signature motif; other site
490759003481	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
490759003482	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
490759003483	TM-ABC transporter signature motif; other site
490759003484	ornithine cyclodeaminase; Validated; Region: PRK06141
490759003485	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
490759003486	Methyltransferase domain; Region: Methyltransf_23; pfam13489
490759003487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759003488	S-adenosylmethionine binding site [chemical binding]; other site
490759003489	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205
490759003490	PLD-like domain; Region: PLDc_2; pfam13091
490759003491	putative homodimer interface [polypeptide binding]; other site
490759003492	putative active site [active]
490759003493	catalytic site [active]
490759003494	DEAD-like helicases superfamily; Region: DEXDc; smart00487
490759003495	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
490759003496	ATP binding site [chemical binding]; other site
490759003497	putative Mg++ binding site [ion binding]; other site
490759003498	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759003499	nucleotide binding region [chemical binding]; other site
490759003500	ATP-binding site [chemical binding]; other site
490759003501	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
490759003502	Catalytic site [active]
490759003503	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
490759003504	Putative transcription activator [Transcription]; Region: TenA; COG0819
490759003505	conserved hypothetical protein; Region: TIGR02231
490759003506	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
490759003507	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
490759003508	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
490759003509	catalytic triad [active]
490759003510	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
490759003511	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
490759003512	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
490759003513	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
490759003514	dimer interface [polypeptide binding]; other site
490759003515	active site
490759003516	metal binding site [ion binding]; metal-binding site
490759003517	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
490759003518	homotrimer interaction site [polypeptide binding]; other site
490759003519	putative active site [active]
490759003520	Protein of unknown function (DUF3726); Region: DUF3726; pfam12525
490759003521	BCCT family transporter; Region: BCCT; pfam02028
490759003522	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
490759003523	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
490759003524	active site
490759003525	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
490759003526	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
490759003527	NAD(P) binding site [chemical binding]; other site
490759003528	catalytic residues [active]
490759003529	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759003530	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759003531	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
490759003532	putative dimerization interface [polypeptide binding]; other site
490759003533	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
490759003534	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
490759003535	Coenzyme A transferase; Region: CoA_trans; cl17247
490759003536	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
490759003537	DctM-like transporters; Region: DctM; pfam06808
490759003538	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
490759003539	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759003540	membrane-bound complex binding site; other site
490759003541	Transcriptional regulator [Transcription]; Region: IclR; COG1414
490759003542	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
490759003543	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
490759003544	ligand binding site [chemical binding]; other site
490759003545	flexible hinge region; other site
490759003546	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
490759003547	putative switch regulator; other site
490759003548	non-specific DNA interactions [nucleotide binding]; other site
490759003549	DNA binding site [nucleotide binding]
490759003550	sequence specific DNA binding site [nucleotide binding]; other site
490759003551	putative cAMP binding site [chemical binding]; other site
490759003552	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
490759003553	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
490759003554	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
490759003555	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
490759003556	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
490759003557	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
490759003558	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
490759003559	hydroxyglutarate oxidase; Provisional; Region: PRK11728
490759003560	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
490759003561	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
490759003562	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
490759003563	active site
490759003564	FMN binding site [chemical binding]; other site
490759003565	substrate binding site [chemical binding]; other site
490759003566	3Fe-4S cluster binding site [ion binding]; other site
490759003567	BCCT family transporter; Region: BCCT; pfam02028
490759003568	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
490759003569	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
490759003570	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
490759003571	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
490759003572	RmuC family; Region: RmuC; pfam02646
490759003573	enoyl-CoA hydratase; Provisional; Region: PRK06688
490759003574	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759003575	substrate binding site [chemical binding]; other site
490759003576	oxyanion hole (OAH) forming residues; other site
490759003577	trimer interface [polypeptide binding]; other site
490759003578	putative fumarate hydratase; Provisional; Region: PRK15392
490759003579	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
490759003580	Fumarase C-terminus; Region: Fumerase_C; pfam05683
490759003581	Uncharacterized conserved protein [Function unknown]; Region: COG0397
490759003582	hypothetical protein; Validated; Region: PRK00029
490759003583	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
490759003584	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759003585	active site
490759003586	motif I; other site
490759003587	motif II; other site
490759003588	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
490759003589	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
490759003590	trehalose synthase; Region: treS_nterm; TIGR02456
490759003591	active site
490759003592	homodimer interface [polypeptide binding]; other site
490759003593	catalytic site [active]
490759003594	Domain of unknown function (DUF3524); Region: DUF3524; pfam12038
490759003595	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
490759003596	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
490759003597	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
490759003598	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
490759003599	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
490759003600	dimer interface [polypeptide binding]; other site
490759003601	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
490759003602	active site
490759003603	metal binding site [ion binding]; metal-binding site
490759003604	glutathione binding site [chemical binding]; other site
490759003605	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
490759003606	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
490759003607	DNA-binding site [nucleotide binding]; DNA binding site
490759003608	RNA-binding motif; other site
490759003609	SlyX; Region: SlyX; pfam04102
490759003610	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
490759003611	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
490759003612	metal binding site [ion binding]; metal-binding site
490759003613	dimer interface [polypeptide binding]; other site
490759003614	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
490759003615	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
490759003616	putative trimer interface [polypeptide binding]; other site
490759003617	putative CoA binding site [chemical binding]; other site
490759003618	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
490759003619	ArsC family; Region: ArsC; pfam03960
490759003620	putative catalytic residues [active]
490759003621	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
490759003622	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
490759003623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759003624	homodimer interface [polypeptide binding]; other site
490759003625	catalytic residue [active]
490759003626	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
490759003627	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
490759003628	metal binding triad; other site
490759003629	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
490759003630	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
490759003631	Zn2+ binding site [ion binding]; other site
490759003632	Mg2+ binding site [ion binding]; other site
490759003633	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
490759003634	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
490759003635	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
490759003636	active site
490759003637	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
490759003638	rRNA interaction site [nucleotide binding]; other site
490759003639	S8 interaction site; other site
490759003640	putative laminin-1 binding site; other site
490759003641	elongation factor Ts; Provisional; Region: tsf; PRK09377
490759003642	UBA/TS-N domain; Region: UBA; pfam00627
490759003643	Elongation factor TS; Region: EF_TS; pfam00889
490759003644	Elongation factor TS; Region: EF_TS; pfam00889
490759003645	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
490759003646	putative nucleotide binding site [chemical binding]; other site
490759003647	uridine monophosphate binding site [chemical binding]; other site
490759003648	homohexameric interface [polypeptide binding]; other site
490759003649	ribosome recycling factor; Reviewed; Region: frr; PRK00083
490759003650	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
490759003651	hinge region; other site
490759003652	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
490759003653	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
490759003654	catalytic residue [active]
490759003655	putative FPP diphosphate  binding site; other site
490759003656	putative FPP binding hydrophobic cleft; other site
490759003657	dimer interface [polypeptide binding]; other site
490759003658	putative IPP diphosphate binding site; other site
490759003659	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
490759003660	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
490759003661	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
490759003662	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
490759003663	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
490759003664	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
490759003665	zinc metallopeptidase RseP; Provisional; Region: PRK10779
490759003666	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
490759003667	active site
490759003668	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
490759003669	protein binding site [polypeptide binding]; other site
490759003670	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
490759003671	protein binding site [polypeptide binding]; other site
490759003672	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
490759003673	putative substrate binding region [chemical binding]; other site
490759003674	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
490759003675	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
490759003676	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
490759003677	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
490759003678	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
490759003679	Surface antigen; Region: Bac_surface_Ag; pfam01103
490759003680	periplasmic chaperone; Provisional; Region: PRK10780
490759003681	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
490759003682	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
490759003683	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
490759003684	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
490759003685	trimer interface [polypeptide binding]; other site
490759003686	active site
490759003687	UDP-GlcNAc binding site [chemical binding]; other site
490759003688	lipid binding site [chemical binding]; lipid-binding site
490759003689	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
490759003690	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
490759003691	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
490759003692	active site
490759003693	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
490759003694	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
490759003695	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
490759003696	RNA/DNA hybrid binding site [nucleotide binding]; other site
490759003697	active site
490759003698	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759003699	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
490759003700	HipA-like N-terminal domain; Region: HipA_N; pfam07805
490759003701	Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560
490759003702	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
490759003703	putative active site [active]
490759003704	catalytic site [active]
490759003705	putative metal binding site [ion binding]; other site
490759003706	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
490759003707	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
490759003708	Domain of unknown function (DUF1850); Region: DUF1850; cl01950
490759003709	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
490759003710	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
490759003711	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
490759003712	conserved cys residue [active]
490759003713	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
490759003714	Isochorismatase family; Region: Isochorismatase; pfam00857
490759003715	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
490759003716	catalytic triad [active]
490759003717	conserved cis-peptide bond; other site
490759003718	FMN-binding domain; Region: FMN_bind; cl01081
490759003719	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
490759003720	4Fe-4S binding domain; Region: Fer4_5; pfam12801
490759003721	4Fe-4S binding domain; Region: Fer4_5; pfam12801
490759003722	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
490759003723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759003724	Response regulator receiver domain; Region: Response_reg; pfam00072
490759003725	active site
490759003726	phosphorylation site [posttranslational modification]
490759003727	intermolecular recognition site; other site
490759003728	dimerization interface [polypeptide binding]; other site
490759003729	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
490759003730	DNA binding residues [nucleotide binding]
490759003731	dimerization interface [polypeptide binding]; other site
490759003732	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
490759003733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
490759003734	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759003735	dimer interface [polypeptide binding]; other site
490759003736	phosphorylation site [posttranslational modification]
490759003737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759003738	ATP binding site [chemical binding]; other site
490759003739	Mg2+ binding site [ion binding]; other site
490759003740	G-X-G motif; other site
490759003741	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
490759003742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759003743	active site
490759003744	phosphorylation site [posttranslational modification]
490759003745	intermolecular recognition site; other site
490759003746	dimerization interface [polypeptide binding]; other site
490759003747	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
490759003748	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
490759003749	putative ligand binding site [chemical binding]; other site
490759003750	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
490759003751	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
490759003752	TM-ABC transporter signature motif; other site
490759003753	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
490759003754	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
490759003755	TM-ABC transporter signature motif; other site
490759003756	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
490759003757	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
490759003758	Walker A/P-loop; other site
490759003759	ATP binding site [chemical binding]; other site
490759003760	Q-loop/lid; other site
490759003761	ABC transporter signature motif; other site
490759003762	Walker B; other site
490759003763	D-loop; other site
490759003764	H-loop/switch region; other site
490759003765	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
490759003766	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
490759003767	Walker A/P-loop; other site
490759003768	ATP binding site [chemical binding]; other site
490759003769	Q-loop/lid; other site
490759003770	ABC transporter signature motif; other site
490759003771	Walker B; other site
490759003772	D-loop; other site
490759003773	H-loop/switch region; other site
490759003774	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
490759003775	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
490759003776	multimer interface [polypeptide binding]; other site
490759003777	active site
490759003778	catalytic triad [active]
490759003779	dimer interface [polypeptide binding]; other site
490759003780	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
490759003781	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759003782	Walker A motif; other site
490759003783	ATP binding site [chemical binding]; other site
490759003784	Walker B motif; other site
490759003785	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
490759003786	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
490759003787	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
490759003788	Gram-negative porin; Region: Porin_4; pfam13609
490759003789	Uncharacterized conserved protein [Function unknown]; Region: COG3287
490759003790	FIST N domain; Region: FIST; pfam08495
490759003791	FIST C domain; Region: FIST_C; pfam10442
490759003792	PAS fold; Region: PAS_7; pfam12860
490759003793	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
490759003794	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759003795	putative active site [active]
490759003796	heme pocket [chemical binding]; other site
490759003797	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759003798	dimer interface [polypeptide binding]; other site
490759003799	phosphorylation site [posttranslational modification]
490759003800	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759003801	ATP binding site [chemical binding]; other site
490759003802	Mg2+ binding site [ion binding]; other site
490759003803	G-X-G motif; other site
490759003804	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
490759003805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759003806	active site
490759003807	phosphorylation site [posttranslational modification]
490759003808	intermolecular recognition site; other site
490759003809	dimerization interface [polypeptide binding]; other site
490759003810	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
490759003811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759003812	active site
490759003813	phosphorylation site [posttranslational modification]
490759003814	intermolecular recognition site; other site
490759003815	dimerization interface [polypeptide binding]; other site
490759003816	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
490759003817	DNA binding residues [nucleotide binding]
490759003818	dimerization interface [polypeptide binding]; other site
490759003819	alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861
490759003820	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
490759003821	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
490759003822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759003823	Walker A/P-loop; other site
490759003824	ATP binding site [chemical binding]; other site
490759003825	Q-loop/lid; other site
490759003826	ABC transporter signature motif; other site
490759003827	Walker B; other site
490759003828	D-loop; other site
490759003829	H-loop/switch region; other site
490759003830	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
490759003831	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
490759003832	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
490759003833	structural tetrad; other site
490759003834	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
490759003835	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
490759003836	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
490759003837	ligand binding site [chemical binding]; other site
490759003838	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
490759003839	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759003840	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759003841	substrate binding pocket [chemical binding]; other site
490759003842	membrane-bound complex binding site; other site
490759003843	hinge residues; other site
490759003844	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
490759003845	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
490759003846	dimer interface [polypeptide binding]; other site
490759003847	Trp docking motif [polypeptide binding]; other site
490759003848	active site
490759003849	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
490759003850	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
490759003851	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
490759003852	Walker A/P-loop; other site
490759003853	ATP binding site [chemical binding]; other site
490759003854	Q-loop/lid; other site
490759003855	ABC transporter signature motif; other site
490759003856	Walker B; other site
490759003857	D-loop; other site
490759003858	H-loop/switch region; other site
490759003859	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
490759003860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759003861	dimer interface [polypeptide binding]; other site
490759003862	conserved gate region; other site
490759003863	putative PBP binding loops; other site
490759003864	ABC-ATPase subunit interface; other site
490759003865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759003866	dimer interface [polypeptide binding]; other site
490759003867	ABC-ATPase subunit interface; other site
490759003868	putative PBP binding loops; other site
490759003869	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759003870	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759003871	substrate binding pocket [chemical binding]; other site
490759003872	membrane-bound complex binding site; other site
490759003873	hinge residues; other site
490759003874	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
490759003875	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
490759003876	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
490759003877	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
490759003878	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
490759003879	NAD(P) binding site [chemical binding]; other site
490759003880	catalytic residues [active]
490759003881	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
490759003882	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
490759003883	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
490759003884	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
490759003885	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
490759003886	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
490759003887	FeS/SAM binding site; other site
490759003888	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
490759003889	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
490759003890	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
490759003891	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
490759003892	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
490759003893	putative active site [active]
490759003894	metal binding site [ion binding]; metal-binding site
490759003895	PAS domain S-box; Region: sensory_box; TIGR00229
490759003896	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759003897	putative active site [active]
490759003898	heme pocket [chemical binding]; other site
490759003899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
490759003900	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759003901	dimer interface [polypeptide binding]; other site
490759003902	phosphorylation site [posttranslational modification]
490759003903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759003904	ATP binding site [chemical binding]; other site
490759003905	Mg2+ binding site [ion binding]; other site
490759003906	G-X-G motif; other site
490759003907	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
490759003908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759003909	active site
490759003910	phosphorylation site [posttranslational modification]
490759003911	intermolecular recognition site; other site
490759003912	dimerization interface [polypeptide binding]; other site
490759003913	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
490759003914	Interdomain contacts; other site
490759003915	Cytokine receptor motif; other site
490759003916	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
490759003917	FecR protein; Region: FecR; pfam04773
490759003918	DNA topoisomerase III; Provisional; Region: PRK07726
490759003919	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
490759003920	active site
490759003921	putative interdomain interaction site [polypeptide binding]; other site
490759003922	putative metal-binding site [ion binding]; other site
490759003923	putative nucleotide binding site [chemical binding]; other site
490759003924	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
490759003925	DNA binding groove [nucleotide binding]
490759003926	domain I; other site
490759003927	phosphate binding site [ion binding]; other site
490759003928	domain II; other site
490759003929	domain III; other site
490759003930	nucleotide binding site [chemical binding]; other site
490759003931	catalytic site [active]
490759003932	domain IV; other site
490759003933	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
490759003934	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
490759003935	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
490759003936	BolA-like protein; Region: BolA; cl00386
490759003937	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
490759003938	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759003939	dimerization interface [polypeptide binding]; other site
490759003940	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
490759003941	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759003942	dimer interface [polypeptide binding]; other site
490759003943	putative CheW interface [polypeptide binding]; other site
490759003944	Predicted membrane protein [Function unknown]; Region: COG2855
490759003945	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759003946	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759003947	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
490759003948	putative dimerization interface [polypeptide binding]; other site
490759003949	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
490759003950	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
490759003951	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
490759003952	arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693
490759003953	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
490759003954	molybdopterin cofactor binding site; other site
490759003955	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
490759003956	molybdopterin cofactor binding site; other site
490759003957	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
490759003958	iron-sulfur cluster [ion binding]; other site
490759003959	[2Fe-2S] cluster binding site [ion binding]; other site
490759003960	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
490759003961	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
490759003962	HEAT repeats; Region: HEAT_2; pfam13646
490759003963	HEAT repeats; Region: HEAT_2; pfam13646
490759003964	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
490759003965	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759003966	putative active site [active]
490759003967	heme pocket [chemical binding]; other site
490759003968	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759003969	dimer interface [polypeptide binding]; other site
490759003970	phosphorylation site [posttranslational modification]
490759003971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759003972	ATP binding site [chemical binding]; other site
490759003973	Mg2+ binding site [ion binding]; other site
490759003974	G-X-G motif; other site
490759003975	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
490759003976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759003977	active site
490759003978	phosphorylation site [posttranslational modification]
490759003979	intermolecular recognition site; other site
490759003980	dimerization interface [polypeptide binding]; other site
490759003981	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759003982	Walker A motif; other site
490759003983	ATP binding site [chemical binding]; other site
490759003984	Walker B motif; other site
490759003985	arginine finger; other site
490759003986	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759003987	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
490759003988	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
490759003989	XdhC Rossmann domain; Region: XdhC_C; pfam13478
490759003990	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
490759003991	Ligand binding site; other site
490759003992	metal-binding site
490759003993	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
490759003994	homodimer interface [polypeptide binding]; other site
490759003995	chemical substrate binding site [chemical binding]; other site
490759003996	oligomer interface [polypeptide binding]; other site
490759003997	metal binding site [ion binding]; metal-binding site
490759003998	GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439
490759003999	GIY-YIG motif/motif A; other site
490759004000	putative active site [active]
490759004001	putative metal binding site [ion binding]; other site
490759004002	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
490759004003	Uncharacterized conserved protein [Function unknown]; Region: COG3410
490759004004	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
490759004005	Catalytic site [active]
490759004006	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
490759004007	PAS domain S-box; Region: sensory_box; TIGR00229
490759004008	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759004009	putative active site [active]
490759004010	heme pocket [chemical binding]; other site
490759004011	PAS fold; Region: PAS_4; pfam08448
490759004012	PAS domain; Region: PAS; smart00091
490759004013	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759004014	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759004015	metal binding site [ion binding]; metal-binding site
490759004016	active site
490759004017	I-site; other site
490759004018	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759004019	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
490759004020	diiron binding motif [ion binding]; other site
490759004021	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
490759004022	Integrase core domain; Region: rve; pfam00665
490759004023	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
490759004024	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
490759004025	Isochorismatase family; Region: Isochorismatase; pfam00857
490759004026	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
490759004027	catalytic triad [active]
490759004028	conserved cis-peptide bond; other site
490759004029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759004030	putative substrate translocation pore; other site
490759004031	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
490759004032	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759004033	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759004034	dimerization interface [polypeptide binding]; other site
490759004035	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
490759004036	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
490759004037	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
490759004038	NAD(P) binding site [chemical binding]; other site
490759004039	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
490759004040	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
490759004041	P-loop, Walker A motif; other site
490759004042	Base recognition motif; other site
490759004043	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
490759004044	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
490759004045	Amidohydrolase; Region: Amidohydro_2; pfam04909
490759004046	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
490759004047	oligomerization interface [polypeptide binding]; other site
490759004048	active site
490759004049	metal binding site [ion binding]; metal-binding site
490759004050	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
490759004051	Cupin domain; Region: Cupin_2; pfam07883
490759004052	Cupin domain; Region: Cupin_2; cl17218
490759004053	Cupin domain; Region: Cupin_2; pfam07883
490759004054	Cupin domain; Region: Cupin_2; pfam07883
490759004055	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
490759004056	acetolactate synthase catalytic subunit; Validated; Region: PRK08327
490759004057	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
490759004058	PYR/PP interface [polypeptide binding]; other site
490759004059	dimer interface [polypeptide binding]; other site
490759004060	TPP binding site [chemical binding]; other site
490759004061	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
490759004062	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
490759004063	TPP-binding site [chemical binding]; other site
490759004064	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
490759004065	Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107
490759004066	NAD(P) binding site [chemical binding]; other site
490759004067	catalytic residues [active]
490759004068	catalytic residues [active]
490759004069	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
490759004070	EamA-like transporter family; Region: EamA; cl17759
490759004071	EamA-like transporter family; Region: EamA; pfam00892
490759004072	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
490759004073	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
490759004074	homotrimer interaction site [polypeptide binding]; other site
490759004075	putative active site [active]
490759004076	Ethanolamine utilisation protein EutA; Region: EutA; pfam06277
490759004077	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
490759004078	Cupin domain; Region: Cupin_2; cl17218
490759004079	Cupin domain; Region: Cupin_2; pfam07883
490759004080	Cupin domain; Region: Cupin_2; cl17218
490759004081	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
490759004082	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
490759004083	Cupin domain; Region: Cupin_2; cl17218
490759004084	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
490759004085	substrate binding pocket [chemical binding]; other site
490759004086	active site
490759004087	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
490759004088	Cupin domain; Region: Cupin_2; cl17218
490759004089	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
490759004090	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
490759004091	phosphate binding site [ion binding]; other site
490759004092	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
490759004093	Ethanolamine utilisation protein EutA; Region: EutA; pfam06277
490759004094	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
490759004095	nucleotide binding site [chemical binding]; other site
490759004096	Cupin domain; Region: Cupin_2; pfam07883
490759004097	Major Facilitator Superfamily; Region: MFS_1; pfam07690
490759004098	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759004099	putative substrate translocation pore; other site
490759004100	Ethanolamine utilisation protein EutA; Region: EutA; pfam06277
490759004101	Cupin domain; Region: Cupin_2; cl17218
490759004102	Chromate transporter; Region: Chromate_transp; pfam02417
490759004103	Chromate transporter; Region: Chromate_transp; pfam02417
490759004104	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
490759004105	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
490759004106	Walker A/P-loop; other site
490759004107	ATP binding site [chemical binding]; other site
490759004108	Q-loop/lid; other site
490759004109	ABC transporter signature motif; other site
490759004110	Walker B; other site
490759004111	D-loop; other site
490759004112	H-loop/switch region; other site
490759004113	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
490759004114	cobalt transport protein CbiM; Validated; Region: PRK06265
490759004115	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
490759004116	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
490759004117	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
490759004118	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
490759004119	catalytic loop [active]
490759004120	iron binding site [ion binding]; other site
490759004121	Toluene-4-monoxygenase electron transfer component of Pseudomonas mendocina hydroxylates toluene and forms p-cresol as part of a three component toluene-4-monoxygenase system. Electron transfer is from NADH to an NADH:ferredoxin oxidoreductase (TmoF in P; Region: T4MO_e_transfer_like; cd06190
490759004122	FAD binding pocket [chemical binding]; other site
490759004123	FAD binding motif [chemical binding]; other site
490759004124	phosphate binding motif [ion binding]; other site
490759004125	beta-alpha-beta structure motif; other site
490759004126	NAD binding pocket [chemical binding]; other site
490759004127	Transcriptional regulator [Transcription]; Region: IclR; COG1414
490759004128	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
490759004129	Bacterial transcriptional regulator; Region: IclR; pfam01614
490759004130	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
490759004131	[2Fe-2S] cluster binding site [ion binding]; other site
490759004132	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
490759004133	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
490759004134	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
490759004135	alpha subunit interface [polypeptide binding]; other site
490759004136	active site
490759004137	substrate binding site [chemical binding]; other site
490759004138	Fe binding site [ion binding]; other site
490759004139	intersubunit interface [polypeptide binding]; other site
490759004140	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
490759004141	active site
490759004142	Zn2+ binding site [ion binding]; other site
490759004143	Predicted permease; Region: DUF318; cl17795
490759004144	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
490759004145	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
490759004146	acetolactate synthase catalytic subunit; Validated; Region: PRK08327
490759004147	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
490759004148	PYR/PP interface [polypeptide binding]; other site
490759004149	dimer interface [polypeptide binding]; other site
490759004150	TPP binding site [chemical binding]; other site
490759004151	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
490759004152	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
490759004153	dimer interface [polypeptide binding]; other site
490759004154	TPP-binding site [chemical binding]; other site
490759004155	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
490759004156	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
490759004157	TAP-like protein; Region: Abhydrolase_4; pfam08386
490759004158	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
490759004159	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
490759004160	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
490759004161	active site
490759004162	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
490759004163	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
490759004164	heterodimer interface [polypeptide binding]; other site
490759004165	active site
490759004166	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
490759004167	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
490759004168	tetramer interface [polypeptide binding]; other site
490759004169	active site
490759004170	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
490759004171	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
490759004172	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
490759004173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
490759004174	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
490759004175	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
490759004176	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
490759004177	Isochorismatase family; Region: Isochorismatase; pfam00857
490759004178	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
490759004179	catalytic triad [active]
490759004180	conserved cis-peptide bond; other site
490759004181	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
490759004182	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
490759004183	active site
490759004184	catalytic tetrad [active]
490759004185	NMT1/THI5 like; Region: NMT1; pfam09084
490759004186	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
490759004187	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
490759004188	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
490759004189	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
490759004190	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
490759004191	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
490759004192	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759004193	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759004194	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
490759004195	putative dimerization interface [polypeptide binding]; other site
490759004196	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
490759004197	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
490759004198	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
490759004199	classical (c) SDRs; Region: SDR_c; cd05233
490759004200	NAD(P) binding site [chemical binding]; other site
490759004201	active site
490759004202	EamA-like transporter family; Region: EamA; cl17759
490759004203	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
490759004204	active site residue [active]
490759004205	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
490759004206	Cupin domain; Region: Cupin_2; pfam07883
490759004207	Cupin domain; Region: Cupin_2; pfam07883
490759004208	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
490759004209	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
490759004210	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
490759004211	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
490759004212	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
490759004213	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
490759004214	classical (c) SDRs; Region: SDR_c; cd05233
490759004215	NAD(P) binding site [chemical binding]; other site
490759004216	active site
490759004217	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
490759004218	Predicted permease; Region: DUF318; cl17795
490759004219	Predicted permease; Region: DUF318; cl17795
490759004220	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
490759004221	Ligand Binding Site [chemical binding]; other site
490759004222	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
490759004223	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
490759004224	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
490759004225	classical (c) SDRs; Region: SDR_c; cd05233
490759004226	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
490759004227	NAD(P) binding site [chemical binding]; other site
490759004228	active site
490759004229	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
490759004230	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
490759004231	active site
490759004232	iron coordination sites [ion binding]; other site
490759004233	substrate binding pocket [chemical binding]; other site
490759004234	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
490759004235	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
490759004236	DinB family; Region: DinB; cl17821
490759004237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759004238	putative substrate translocation pore; other site
490759004239	Major Facilitator Superfamily; Region: MFS_1; pfam07690
490759004240	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
490759004241	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
490759004242	Transposase; Region: HTH_Tnp_1; pfam01527
490759004243	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
490759004244	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
490759004245	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
490759004246	Probable Catalytic site; other site
490759004247	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
490759004248	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
490759004249	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
490759004250	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
490759004251	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
490759004252	short chain dehydrogenase; Provisional; Region: PRK07201
490759004253	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
490759004254	putative NAD(P) binding site [chemical binding]; other site
490759004255	active site
490759004256	putative substrate binding site [chemical binding]; other site
490759004257	classical (c) SDRs; Region: SDR_c; cd05233
490759004258	NAD(P) binding site [chemical binding]; other site
490759004259	active site
490759004260	ribonuclease T; Provisional; Region: PRK05168
490759004261	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
490759004262	active site
490759004263	catalytic site [active]
490759004264	substrate binding site [chemical binding]; other site
490759004265	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
490759004266	active site
490759004267	substrate binding pocket [chemical binding]; other site
490759004268	dimer interface [polypeptide binding]; other site
490759004269	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
490759004270	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
490759004271	ligand binding site [chemical binding]; other site
490759004272	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
490759004273	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
490759004274	putative active site [active]
490759004275	Zn binding site [ion binding]; other site
490759004276	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
490759004277	CoA binding domain; Region: CoA_binding_2; pfam13380
490759004278	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
490759004279	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
490759004280	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
490759004281	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
490759004282	Putative exonuclease, RdgC; Region: RdgC; pfam04381
490759004283	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
490759004284	hypothetical protein; Validated; Region: PRK02101
490759004285	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
490759004286	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
490759004287	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759004288	NAD(P) binding site [chemical binding]; other site
490759004289	active site
490759004290	phosphoglycolate phosphatase; Provisional; Region: PRK13222
490759004291	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759004292	motif II; other site
490759004293	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
490759004294	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759004295	S-adenosylmethionine binding site [chemical binding]; other site
490759004296	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
490759004297	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
490759004298	active site
490759004299	putative substrate binding pocket [chemical binding]; other site
490759004300	carboxy-terminal protease; Provisional; Region: PRK11186
490759004301	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
490759004302	protein binding site [polypeptide binding]; other site
490759004303	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
490759004304	Catalytic dyad [active]
490759004305	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
490759004306	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
490759004307	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
490759004308	recombination regulator RecX; Reviewed; Region: recX; PRK00117
490759004309	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
490759004310	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759004311	substrate binding pocket [chemical binding]; other site
490759004312	membrane-bound complex binding site; other site
490759004313	hinge residues; other site
490759004314	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
490759004315	N-acetyl-D-glucosamine binding site [chemical binding]; other site
490759004316	catalytic residue [active]
490759004317	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
490759004318	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
490759004319	dimerization interface [polypeptide binding]; other site
490759004320	ATP binding site [chemical binding]; other site
490759004321	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
490759004322	dimerization interface [polypeptide binding]; other site
490759004323	ATP binding site [chemical binding]; other site
490759004324	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
490759004325	putative active site [active]
490759004326	catalytic triad [active]
490759004327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
490759004328	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
490759004329	nudix motif; other site
490759004330	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
490759004331	putative active site [active]
490759004332	putative CoA binding site [chemical binding]; other site
490759004333	nudix motif; other site
490759004334	metal binding site [ion binding]; metal-binding site
490759004335	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
490759004336	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
490759004337	trimer interface [polypeptide binding]; other site
490759004338	putative metal binding site [ion binding]; other site
490759004339	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
490759004340	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
490759004341	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759004342	ATP-grasp domain; Region: ATP-grasp; pfam02222
490759004343	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
490759004344	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759004345	ATP binding site [chemical binding]; other site
490759004346	Mg2+ binding site [ion binding]; other site
490759004347	G-X-G motif; other site
490759004348	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
490759004349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759004350	active site
490759004351	phosphorylation site [posttranslational modification]
490759004352	intermolecular recognition site; other site
490759004353	dimerization interface [polypeptide binding]; other site
490759004354	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759004355	binding surface
490759004356	TPR repeat; Region: TPR_11; pfam13414
490759004357	TPR motif; other site
490759004358	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
490759004359	Na binding site [ion binding]; other site
490759004360	PAS fold; Region: PAS_7; pfam12860
490759004361	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
490759004362	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759004363	dimer interface [polypeptide binding]; other site
490759004364	phosphorylation site [posttranslational modification]
490759004365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759004366	ATP binding site [chemical binding]; other site
490759004367	Mg2+ binding site [ion binding]; other site
490759004368	G-X-G motif; other site
490759004369	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
490759004370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759004371	active site
490759004372	phosphorylation site [posttranslational modification]
490759004373	intermolecular recognition site; other site
490759004374	dimerization interface [polypeptide binding]; other site
490759004375	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
490759004376	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
490759004377	Na binding site [ion binding]; other site
490759004378	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
490759004379	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
490759004380	active site
490759004381	catalytic site [active]
490759004382	substrate binding site [chemical binding]; other site
490759004383	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
490759004384	metal binding triad; other site
490759004385	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
490759004386	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
490759004387	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
490759004388	ligand binding site [chemical binding]; other site
490759004389	flexible hinge region; other site
490759004390	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
490759004391	FOG: CBS domain [General function prediction only]; Region: COG0517
490759004392	FOG: CBS domain [General function prediction only]; Region: COG0517
490759004393	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
490759004394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
490759004395	Smr domain; Region: Smr; pfam01713
490759004396	Protein of unknown function (DUF3080); Region: DUF3080; pfam11279
490759004397	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
490759004398	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
490759004399	Walker A motif; other site
490759004400	ATP binding site [chemical binding]; other site
490759004401	Walker B motif; other site
490759004402	Predicted membrane protein (DUF2069); Region: DUF2069; cl01299
490759004403	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
490759004404	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
490759004405	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
490759004406	ArsC family; Region: ArsC; pfam03960
490759004407	catalytic residues [active]
490759004408	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
490759004409	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
490759004410	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
490759004411	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
490759004412	putative active site [active]
490759004413	putative PHP Thumb interface [polypeptide binding]; other site
490759004414	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
490759004415	generic binding surface II; other site
490759004416	generic binding surface I; other site
490759004417	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
490759004418	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
490759004419	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
490759004420	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
490759004421	TilS substrate binding domain; Region: TilS; pfam09179
490759004422	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
490759004423	CTP synthetase; Validated; Region: pyrG; PRK05380
490759004424	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
490759004425	Catalytic site [active]
490759004426	active site
490759004427	UTP binding site [chemical binding]; other site
490759004428	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
490759004429	active site
490759004430	putative oxyanion hole; other site
490759004431	catalytic triad [active]
490759004432	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
490759004433	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
490759004434	enolase; Provisional; Region: eno; PRK00077
490759004435	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
490759004436	dimer interface [polypeptide binding]; other site
490759004437	metal binding site [ion binding]; metal-binding site
490759004438	substrate binding pocket [chemical binding]; other site
490759004439	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
490759004440	Septum formation initiator; Region: DivIC; cl17659
490759004441	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
490759004442	substrate binding site; other site
490759004443	dimer interface; other site
490759004444	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
490759004445	homotrimer interaction site [polypeptide binding]; other site
490759004446	zinc binding site [ion binding]; other site
490759004447	CDP-binding sites; other site
490759004448	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
490759004449	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
490759004450	Permutation of conserved domain; other site
490759004451	active site
490759004452	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
490759004453	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
490759004454	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759004455	S-adenosylmethionine binding site [chemical binding]; other site
490759004456	Domain of unknown function (DUF368); Region: DUF368; pfam04018
490759004457	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
490759004458	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
490759004459	Peptidase family M23; Region: Peptidase_M23; pfam01551
490759004460	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
490759004461	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
490759004462	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
490759004463	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
490759004464	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
490759004465	DNA binding residues [nucleotide binding]
490759004466	endonuclease III; Provisional; Region: PRK10702
490759004467	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
490759004468	minor groove reading motif; other site
490759004469	helix-hairpin-helix signature motif; other site
490759004470	substrate binding pocket [chemical binding]; other site
490759004471	active site
490759004472	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
490759004473	electron transport complex RsxE subunit; Provisional; Region: PRK12405
490759004474	FMN-binding domain; Region: FMN_bind; cl01081
490759004475	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
490759004476	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
490759004477	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
490759004478	SLBB domain; Region: SLBB; pfam10531
490759004479	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
490759004480	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
490759004481	ferredoxin; Provisional; Region: PRK08764
490759004482	Putative Fe-S cluster; Region: FeS; pfam04060
490759004483	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
490759004484	electron transport complex protein RsxA; Provisional; Region: PRK05151
490759004485	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
490759004486	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
490759004487	active site
490759004488	HIGH motif; other site
490759004489	KMSKS motif; other site
490759004490	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
490759004491	tRNA binding surface [nucleotide binding]; other site
490759004492	anticodon binding site; other site
490759004493	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
490759004494	dimer interface [polypeptide binding]; other site
490759004495	putative tRNA-binding site [nucleotide binding]; other site
490759004496	antiporter inner membrane protein; Provisional; Region: PRK11670
490759004497	Domain of unknown function DUF59; Region: DUF59; pfam01883
490759004498	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
490759004499	Walker A motif; other site
490759004500	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
490759004501	trimer interface [polypeptide binding]; other site
490759004502	active site
490759004503	Protein of unknown function (DUF416); Region: DUF416; pfam04222
490759004504	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
490759004505	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
490759004506	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759004507	homodimer interface [polypeptide binding]; other site
490759004508	catalytic residue [active]
490759004509	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
490759004510	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
490759004511	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
490759004512	active site
490759004513	substrate binding site [chemical binding]; other site
490759004514	cosubstrate binding site; other site
490759004515	catalytic site [active]
490759004516	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
490759004517	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
490759004518	dimerization interface [polypeptide binding]; other site
490759004519	putative ATP binding site [chemical binding]; other site
490759004520	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
490759004521	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
490759004522	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
490759004523	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
490759004524	Walker A motif; other site
490759004525	ATP binding site [chemical binding]; other site
490759004526	Walker B motif; other site
490759004527	arginine finger; other site
490759004528	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
490759004529	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
490759004530	P-loop; other site
490759004531	Magnesium ion binding site [ion binding]; other site
490759004532	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
490759004533	Magnesium ion binding site [ion binding]; other site
490759004534	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
490759004535	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
490759004536	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
490759004537	dimerization interface [polypeptide binding]; other site
490759004538	active site
490759004539	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
490759004540	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
490759004541	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
490759004542	amidase catalytic site [active]
490759004543	substrate binding site [chemical binding]; other site
490759004544	Zn binding residues [ion binding]; other site
490759004545	CobD/Cbib protein; Region: CobD_Cbib; cl00561
490759004546	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759004547	dimerization interface [polypeptide binding]; other site
490759004548	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
490759004549	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759004550	dimer interface [polypeptide binding]; other site
490759004551	putative CheW interface [polypeptide binding]; other site
490759004552	siroheme synthase; Provisional; Region: cysG; PRK10637
490759004553	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
490759004554	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
490759004555	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
490759004556	active site
490759004557	SAM binding site [chemical binding]; other site
490759004558	homodimer interface [polypeptide binding]; other site
490759004559	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
490759004560	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
490759004561	Active Sites [active]
490759004562	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
490759004563	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
490759004564	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
490759004565	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
490759004566	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
490759004567	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
490759004568	Active Sites [active]
490759004569	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
490759004570	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
490759004571	CysD dimerization site [polypeptide binding]; other site
490759004572	G1 box; other site
490759004573	putative GEF interaction site [polypeptide binding]; other site
490759004574	GTP/Mg2+ binding site [chemical binding]; other site
490759004575	Switch I region; other site
490759004576	G2 box; other site
490759004577	G3 box; other site
490759004578	Switch II region; other site
490759004579	G4 box; other site
490759004580	G5 box; other site
490759004581	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
490759004582	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
490759004583	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
490759004584	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
490759004585	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
490759004586	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
490759004587	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
490759004588	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
490759004589	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
490759004590	HIGH motif; other site
490759004591	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
490759004592	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
490759004593	active site
490759004594	KMSKS motif; other site
490759004595	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
490759004596	tRNA binding surface [nucleotide binding]; other site
490759004597	anticodon binding site; other site
490759004598	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
490759004599	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
490759004600	multifunctional aminopeptidase A; Provisional; Region: PRK00913
490759004601	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
490759004602	interface (dimer of trimers) [polypeptide binding]; other site
490759004603	Substrate-binding/catalytic site; other site
490759004604	Zn-binding sites [ion binding]; other site
490759004605	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
490759004606	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
490759004607	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
490759004608	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
490759004609	RDD family; Region: RDD; pfam06271
490759004610	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
490759004611	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
490759004612	motif 1; other site
490759004613	active site
490759004614	motif 2; other site
490759004615	motif 3; other site
490759004616	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
490759004617	DHHA1 domain; Region: DHHA1; pfam02272
490759004618	aspartate kinase; Reviewed; Region: PRK06635
490759004619	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
490759004620	putative nucleotide binding site [chemical binding]; other site
490759004621	putative catalytic residues [active]
490759004622	putative Mg ion binding site [ion binding]; other site
490759004623	putative aspartate binding site [chemical binding]; other site
490759004624	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
490759004625	putative allosteric regulatory site; other site
490759004626	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
490759004627	putative allosteric regulatory residue; other site
490759004628	carbon storage regulator; Provisional; Region: PRK01712
490759004629	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
490759004630	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
490759004631	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
490759004632	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
490759004633	DctM-like transporters; Region: DctM; pfam06808
490759004634	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
490759004635	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
490759004636	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759004637	dimer interface [polypeptide binding]; other site
490759004638	phosphorylation site [posttranslational modification]
490759004639	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759004640	ATP binding site [chemical binding]; other site
490759004641	Mg2+ binding site [ion binding]; other site
490759004642	G-X-G motif; other site
490759004643	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
490759004644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759004645	active site
490759004646	phosphorylation site [posttranslational modification]
490759004647	intermolecular recognition site; other site
490759004648	dimerization interface [polypeptide binding]; other site
490759004649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759004650	Walker A motif; other site
490759004651	ATP binding site [chemical binding]; other site
490759004652	Walker B motif; other site
490759004653	arginine finger; other site
490759004654	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759004655	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
490759004656	putative Zn2+ binding site [ion binding]; other site
490759004657	putative DNA binding site [nucleotide binding]; other site
490759004658	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
490759004659	DctM-like transporters; Region: DctM; pfam06808
490759004660	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
490759004661	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
490759004662	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759004663	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
490759004664	putative active site [active]
490759004665	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
490759004666	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
490759004667	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
490759004668	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
490759004669	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
490759004670	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
490759004671	ATP binding site [chemical binding]; other site
490759004672	Mg++ binding site [ion binding]; other site
490759004673	motif III; other site
490759004674	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759004675	nucleotide binding region [chemical binding]; other site
490759004676	ATP-binding site [chemical binding]; other site
490759004677	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
490759004678	putative RNA binding site [nucleotide binding]; other site
490759004679	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
490759004680	oxaloacetate decarboxylase; Provisional; Region: PRK14040
490759004681	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
490759004682	active site
490759004683	catalytic residues [active]
490759004684	metal binding site [ion binding]; metal-binding site
490759004685	homodimer binding site [polypeptide binding]; other site
490759004686	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
490759004687	carboxyltransferase (CT) interaction site; other site
490759004688	biotinylation site [posttranslational modification]; other site
490759004689	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
490759004690	Pirin-related protein [General function prediction only]; Region: COG1741
490759004691	Pirin; Region: Pirin; pfam02678
490759004692	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
490759004693	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
490759004694	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
490759004695	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
490759004696	putative dimer interface [polypeptide binding]; other site
490759004697	N-terminal domain interface [polypeptide binding]; other site
490759004698	putative substrate binding pocket (H-site) [chemical binding]; other site
490759004699	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
490759004700	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
490759004701	Predicted membrane protein [Function unknown]; Region: COG2259
490759004702	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759004703	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759004704	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759004705	dimerization interface [polypeptide binding]; other site
490759004706	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
490759004707	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
490759004708	putative active site [active]
490759004709	putative PHP Thumb interface [polypeptide binding]; other site
490759004710	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
490759004711	generic binding surface I; other site
490759004712	generic binding surface II; other site
490759004713	DNA Polymerase Y-family; Region: PolY_like; cd03468
490759004714	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
490759004715	active site
490759004716	DNA binding site [nucleotide binding]
490759004717	Cell division inhibitor SulA; Region: SulA; cl01880
490759004718	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
490759004719	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
490759004720	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
490759004721	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
490759004722	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
490759004723	HlyD family secretion protein; Region: HlyD_3; pfam13437
490759004724	Fusaric acid resistance protein family; Region: FUSC; pfam04632
490759004725	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
490759004726	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
490759004727	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
490759004728	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
490759004729	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
490759004730	putative active site [active]
490759004731	putative substrate binding site [chemical binding]; other site
490759004732	putative cosubstrate binding site; other site
490759004733	catalytic site [active]
490759004734	DNA gyrase subunit A; Validated; Region: PRK05560
490759004735	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
490759004736	CAP-like domain; other site
490759004737	active site
490759004738	primary dimer interface [polypeptide binding]; other site
490759004739	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
490759004740	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
490759004741	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
490759004742	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
490759004743	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
490759004744	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
490759004745	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
490759004746	homodimer interface [polypeptide binding]; other site
490759004747	substrate-cofactor binding pocket; other site
490759004748	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759004749	catalytic residue [active]
490759004750	Chorismate mutase type II; Region: CM_2; cl00693
490759004751	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
490759004752	Prephenate dehydratase; Region: PDT; pfam00800
490759004753	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
490759004754	putative L-Phe binding site [chemical binding]; other site
490759004755	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
490759004756	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
490759004757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759004758	homodimer interface [polypeptide binding]; other site
490759004759	catalytic residue [active]
490759004760	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
490759004761	prephenate dehydrogenase; Validated; Region: PRK08507
490759004762	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
490759004763	hinge; other site
490759004764	active site
490759004765	cytidylate kinase; Provisional; Region: cmk; PRK00023
490759004766	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
490759004767	CMP-binding site; other site
490759004768	The sites determining sugar specificity; other site
490759004769	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
490759004770	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
490759004771	RNA binding site [nucleotide binding]; other site
490759004772	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
490759004773	RNA binding site [nucleotide binding]; other site
490759004774	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
490759004775	RNA binding site [nucleotide binding]; other site
490759004776	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
490759004777	RNA binding site [nucleotide binding]; other site
490759004778	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
490759004779	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
490759004780	RNA binding site [nucleotide binding]; other site
490759004781	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
490759004782	IHF - DNA interface [nucleotide binding]; other site
490759004783	IHF dimer interface [polypeptide binding]; other site
490759004784	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
490759004785	tetratricopeptide repeat protein; Provisional; Region: PRK11788
490759004786	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
490759004787	active site
490759004788	dimer interface [polypeptide binding]; other site
490759004789	aspartate aminotransferase; Provisional; Region: PRK05764
490759004790	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
490759004791	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759004792	homodimer interface [polypeptide binding]; other site
490759004793	catalytic residue [active]
490759004794	excinuclease ABC subunit B; Provisional; Region: PRK05298
490759004795	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
490759004796	ATP binding site [chemical binding]; other site
490759004797	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759004798	nucleotide binding region [chemical binding]; other site
490759004799	ATP-binding site [chemical binding]; other site
490759004800	Ultra-violet resistance protein B; Region: UvrB; pfam12344
490759004801	UvrB/uvrC motif; Region: UVR; pfam02151
490759004802	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
490759004803	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
490759004804	Coenzyme A binding pocket [chemical binding]; other site
490759004805	Peptidase_C39 like family; Region: DUF3335; pfam11814
490759004806	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
490759004807	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
490759004808	ATP-grasp domain; Region: ATP-grasp_4; cl17255
490759004809	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
490759004810	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
490759004811	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
490759004812	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
490759004813	quinone interaction residues [chemical binding]; other site
490759004814	active site
490759004815	catalytic residues [active]
490759004816	FMN binding site [chemical binding]; other site
490759004817	substrate binding site [chemical binding]; other site
490759004818	Ribosome modulation factor; Region: RMF; pfam04957
490759004819	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
490759004820	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
490759004821	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
490759004822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759004823	S-adenosylmethionine binding site [chemical binding]; other site
490759004824	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
490759004825	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
490759004826	active site
490759004827	metal binding site [ion binding]; metal-binding site
490759004828	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
490759004829	active site
490759004830	catalytic triad [active]
490759004831	oxyanion hole [active]
490759004832	switch loop; other site
490759004833	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
490759004834	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
490759004835	Walker A/P-loop; other site
490759004836	ATP binding site [chemical binding]; other site
490759004837	Q-loop/lid; other site
490759004838	ABC transporter signature motif; other site
490759004839	Walker B; other site
490759004840	D-loop; other site
490759004841	H-loop/switch region; other site
490759004842	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
490759004843	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
490759004844	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189
490759004845	putative active site [active]
490759004846	metal binding site [ion binding]; metal-binding site
490759004847	Peptidase family M48; Region: Peptidase_M48; pfam01435
490759004848	TPR repeat; Region: TPR_11; pfam13414
490759004849	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759004850	TPR motif; other site
490759004851	binding surface
490759004852	heat shock protein 90; Provisional; Region: PRK05218
490759004853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759004854	ATP binding site [chemical binding]; other site
490759004855	Mg2+ binding site [ion binding]; other site
490759004856	G-X-G motif; other site
490759004857	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
490759004858	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
490759004859	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
490759004860	FMN binding site [chemical binding]; other site
490759004861	active site
490759004862	catalytic residues [active]
490759004863	substrate binding site [chemical binding]; other site
490759004864	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
490759004865	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
490759004866	dimer interface [polypeptide binding]; other site
490759004867	active site
490759004868	heme binding site [chemical binding]; other site
490759004869	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
490759004870	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
490759004871	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
490759004872	FMN binding site [chemical binding]; other site
490759004873	substrate binding site [chemical binding]; other site
490759004874	putative catalytic residue [active]
490759004875	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
490759004876	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
490759004877	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
490759004878	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
490759004879	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
490759004880	High potential iron-sulfur protein; Region: HIPIP; pfam01355
490759004881	Predicted integral membrane protein [Function unknown]; Region: COG5615
490759004882	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
490759004883	hypothetical protein; Provisional; Region: PRK11295
490759004884	YcaO domain protein; Region: TIGR03549
490759004885	OsmC-like protein; Region: OsmC; pfam02566
490759004886	YcaO-like family; Region: YcaO; pfam02624
490759004887	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
490759004888	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
490759004889	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
490759004890	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
490759004891	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
490759004892	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
490759004893	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759004894	dimer interface [polypeptide binding]; other site
490759004895	conserved gate region; other site
490759004896	ABC-ATPase subunit interface; other site
490759004897	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
490759004898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759004899	dimer interface [polypeptide binding]; other site
490759004900	conserved gate region; other site
490759004901	ABC-ATPase subunit interface; other site
490759004902	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
490759004903	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
490759004904	Walker A/P-loop; other site
490759004905	ATP binding site [chemical binding]; other site
490759004906	Q-loop/lid; other site
490759004907	ABC transporter signature motif; other site
490759004908	Walker B; other site
490759004909	D-loop; other site
490759004910	H-loop/switch region; other site
490759004911	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
490759004912	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
490759004913	von Willebrand factor type A domain; Region: VWA_2; pfam13519
490759004914	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
490759004915	HSP70 interaction site [polypeptide binding]; other site
490759004916	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
490759004917	homotrimer interaction site [polypeptide binding]; other site
490759004918	putative active site [active]
490759004919	ornithine cyclodeaminase; Validated; Region: PRK06141
490759004920	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
490759004921	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
490759004922	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
490759004923	substrate binding pocket [chemical binding]; other site
490759004924	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
490759004925	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
490759004926	oligomer interface [polypeptide binding]; other site
490759004927	metal binding site [ion binding]; metal-binding site
490759004928	metal binding site [ion binding]; metal-binding site
490759004929	Cl binding site [ion binding]; other site
490759004930	aspartate ring; other site
490759004931	basic sphincter; other site
490759004932	putative hydrophobic gate; other site
490759004933	periplasmic entrance; other site
490759004934	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
490759004935	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
490759004936	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
490759004937	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
490759004938	active site
490759004939	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
490759004940	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
490759004941	Walker A/P-loop; other site
490759004942	ATP binding site [chemical binding]; other site
490759004943	Q-loop/lid; other site
490759004944	ABC transporter signature motif; other site
490759004945	Walker B; other site
490759004946	D-loop; other site
490759004947	H-loop/switch region; other site
490759004948	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
490759004949	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
490759004950	Walker A/P-loop; other site
490759004951	ATP binding site [chemical binding]; other site
490759004952	Q-loop/lid; other site
490759004953	ABC transporter signature motif; other site
490759004954	Walker B; other site
490759004955	D-loop; other site
490759004956	H-loop/switch region; other site
490759004957	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
490759004958	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
490759004959	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
490759004960	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
490759004961	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
490759004962	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
490759004963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759004964	dimer interface [polypeptide binding]; other site
490759004965	conserved gate region; other site
490759004966	putative PBP binding loops; other site
490759004967	ABC-ATPase subunit interface; other site
490759004968	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
490759004969	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
490759004970	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
490759004971	Walker A/P-loop; other site
490759004972	ATP binding site [chemical binding]; other site
490759004973	Q-loop/lid; other site
490759004974	ABC transporter signature motif; other site
490759004975	Walker B; other site
490759004976	D-loop; other site
490759004977	H-loop/switch region; other site
490759004978	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
490759004979	putative hydrolase; Provisional; Region: PRK02113
490759004980	EamA-like transporter family; Region: EamA; pfam00892
490759004981	Flagellin N-methylase; Region: FliB; pfam03692
490759004982	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
490759004983	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
490759004984	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
490759004985	Mechanosensitive ion channel; Region: MS_channel; pfam00924
490759004986	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
490759004987	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
490759004988	CHAD domain; Region: CHAD; pfam05235
490759004989	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
490759004990	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759004991	Walker A/P-loop; other site
490759004992	ATP binding site [chemical binding]; other site
490759004993	Q-loop/lid; other site
490759004994	ABC transporter signature motif; other site
490759004995	Walker B; other site
490759004996	D-loop; other site
490759004997	H-loop/switch region; other site
490759004998	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
490759004999	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759005000	dimer interface [polypeptide binding]; other site
490759005001	conserved gate region; other site
490759005002	putative PBP binding loops; other site
490759005003	ABC-ATPase subunit interface; other site
490759005004	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
490759005005	Fatty acid desaturase; Region: FA_desaturase; pfam00487
490759005006	Di-iron ligands [ion binding]; other site
490759005007	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
490759005008	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
490759005009	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
490759005010	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
490759005011	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
490759005012	dimer interface [polypeptide binding]; other site
490759005013	decamer (pentamer of dimers) interface [polypeptide binding]; other site
490759005014	catalytic triad [active]
490759005015	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
490759005016	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
490759005017	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
490759005018	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
490759005019	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
490759005020	catalytic residue [active]
490759005021	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
490759005022	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
490759005023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759005024	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
490759005025	Walker A/P-loop; other site
490759005026	ATP binding site [chemical binding]; other site
490759005027	Q-loop/lid; other site
490759005028	ABC transporter signature motif; other site
490759005029	Walker B; other site
490759005030	D-loop; other site
490759005031	H-loop/switch region; other site
490759005032	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
490759005033	Patatin-like phospholipase; Region: Patatin; pfam01734
490759005034	active site
490759005035	nucleophile elbow; other site
490759005036	short chain dehydrogenase; Provisional; Region: PRK07576
490759005037	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
490759005038	NAD(P) binding site [chemical binding]; other site
490759005039	substrate binding site [chemical binding]; other site
490759005040	homotetramer interface [polypeptide binding]; other site
490759005041	active site
490759005042	homodimer interface [polypeptide binding]; other site
490759005043	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
490759005044	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
490759005045	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
490759005046	putative N-terminal domain interface [polypeptide binding]; other site
490759005047	putative dimer interface [polypeptide binding]; other site
490759005048	putative substrate binding pocket (H-site) [chemical binding]; other site
490759005049	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
490759005050	putative active site [active]
490759005051	Zn binding site [ion binding]; other site
490759005052	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
490759005053	Protein of unknown function DUF262; Region: DUF262; pfam03235
490759005054	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
490759005055	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
490759005056	GIY-YIG motif/motif A; other site
490759005057	putative active site [active]
490759005058	putative metal binding site [ion binding]; other site
490759005059	Part of AAA domain; Region: AAA_19; pfam13245
490759005060	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
490759005061	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
490759005062	AAA ATPase domain; Region: AAA_15; pfam13175
490759005063	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
490759005064	putative active site [active]
490759005065	putative metal-binding site [ion binding]; other site
490759005066	TSCPD domain; Region: TSCPD; pfam12637
490759005067	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
490759005068	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
490759005069	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
490759005070	active site
490759005071	dimer interface [polypeptide binding]; other site
490759005072	effector binding site; other site
490759005073	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
490759005074	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
490759005075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759005076	Walker A/P-loop; other site
490759005077	ATP binding site [chemical binding]; other site
490759005078	Q-loop/lid; other site
490759005079	ABC transporter signature motif; other site
490759005080	Walker B; other site
490759005081	D-loop; other site
490759005082	H-loop/switch region; other site
490759005083	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
490759005084	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
490759005085	TM-ABC transporter signature motif; other site
490759005086	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
490759005087	zinc binding site [ion binding]; other site
490759005088	putative ligand binding site [chemical binding]; other site
490759005089	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
490759005090	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
490759005091	acyl-activating enzyme (AAE) consensus motif; other site
490759005092	putative AMP binding site [chemical binding]; other site
490759005093	putative active site [active]
490759005094	putative CoA binding site [chemical binding]; other site
490759005095	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
490759005096	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
490759005097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759005098	dimer interface [polypeptide binding]; other site
490759005099	conserved gate region; other site
490759005100	putative PBP binding loops; other site
490759005101	ABC-ATPase subunit interface; other site
490759005102	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759005103	dimer interface [polypeptide binding]; other site
490759005104	conserved gate region; other site
490759005105	putative PBP binding loops; other site
490759005106	ABC-ATPase subunit interface; other site
490759005107	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
490759005108	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
490759005109	PilZ domain; Region: PilZ; pfam07238
490759005110	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
490759005111	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
490759005112	Walker A/P-loop; other site
490759005113	ATP binding site [chemical binding]; other site
490759005114	Q-loop/lid; other site
490759005115	ABC transporter signature motif; other site
490759005116	Walker B; other site
490759005117	D-loop; other site
490759005118	H-loop/switch region; other site
490759005119	inner membrane transport permease; Provisional; Region: PRK15066
490759005120	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
490759005121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
490759005122	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
490759005123	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
490759005124	MASE2 domain; Region: MASE2; pfam05230
490759005125	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
490759005126	cyclase homology domain; Region: CHD; cd07302
490759005127	nucleotidyl binding site; other site
490759005128	metal binding site [ion binding]; metal-binding site
490759005129	dimer interface [polypeptide binding]; other site
490759005130	Protein of unknown function (DUF962); Region: DUF962; cl01879
490759005131	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
490759005132	putative FMN binding site [chemical binding]; other site
490759005133	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
490759005134	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
490759005135	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
490759005136	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
490759005137	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
490759005138	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
490759005139	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
490759005140	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
490759005141	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
490759005142	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
490759005143	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
490759005144	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
490759005145	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
490759005146	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
490759005147	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
490759005148	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
490759005149	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
490759005150	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
490759005151	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
490759005152	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
490759005153	Flagellar L-ring protein; Region: FlgH; pfam02107
490759005154	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
490759005155	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
490759005156	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
490759005157	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
490759005158	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
490759005159	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
490759005160	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
490759005161	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
490759005162	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
490759005163	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
490759005164	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
490759005165	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
490759005166	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
490759005167	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
490759005168	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
490759005169	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
490759005170	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
490759005171	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
490759005172	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
490759005173	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
490759005174	Protein export membrane protein; Region: SecD_SecF; pfam02355
490759005175	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
490759005176	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
490759005177	active site
490759005178	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
490759005179	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
490759005180	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
490759005181	serine O-acetyltransferase; Region: cysE; TIGR01172
490759005182	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
490759005183	trimer interface [polypeptide binding]; other site
490759005184	active site
490759005185	substrate binding site [chemical binding]; other site
490759005186	CoA binding site [chemical binding]; other site
490759005187	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
490759005188	Rrf2 family protein; Region: rrf2_super; TIGR00738
490759005189	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
490759005190	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
490759005191	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
490759005192	catalytic residue [active]
490759005193	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
490759005194	active site
490759005195	multimer interface [polypeptide binding]; other site
490759005196	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
490759005197	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
490759005198	FeS/SAM binding site; other site
490759005199	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
490759005200	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759005201	binding surface
490759005202	TPR motif; other site
490759005203	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759005204	binding surface
490759005205	TPR motif; other site
490759005206	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
490759005207	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
490759005208	non-specific DNA binding site [nucleotide binding]; other site
490759005209	salt bridge; other site
490759005210	sequence-specific DNA binding site [nucleotide binding]; other site
490759005211	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
490759005212	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
490759005213	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
490759005214	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
490759005215	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
490759005216	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
490759005217	dimer interface [polypeptide binding]; other site
490759005218	motif 1; other site
490759005219	active site
490759005220	motif 2; other site
490759005221	motif 3; other site
490759005222	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
490759005223	anticodon binding site; other site
490759005224	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
490759005225	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
490759005226	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
490759005227	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
490759005228	Trp docking motif [polypeptide binding]; other site
490759005229	active site
490759005230	GTP-binding protein Der; Reviewed; Region: PRK00093
490759005231	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
490759005232	G1 box; other site
490759005233	GTP/Mg2+ binding site [chemical binding]; other site
490759005234	Switch I region; other site
490759005235	G2 box; other site
490759005236	Switch II region; other site
490759005237	G3 box; other site
490759005238	G4 box; other site
490759005239	G5 box; other site
490759005240	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
490759005241	G1 box; other site
490759005242	GTP/Mg2+ binding site [chemical binding]; other site
490759005243	Switch I region; other site
490759005244	G2 box; other site
490759005245	G3 box; other site
490759005246	Switch II region; other site
490759005247	G4 box; other site
490759005248	G5 box; other site
490759005249	phosphate acetyltransferase; Reviewed; Region: PRK05632
490759005250	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
490759005251	DRTGG domain; Region: DRTGG; pfam07085
490759005252	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
490759005253	propionate/acetate kinase; Provisional; Region: PRK12379
490759005254	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
490759005255	HAMP domain; Region: HAMP; pfam00672
490759005256	dimerization interface [polypeptide binding]; other site
490759005257	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759005258	PAS domain; Region: PAS_9; pfam13426
490759005259	putative active site [active]
490759005260	heme pocket [chemical binding]; other site
490759005261	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759005262	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759005263	metal binding site [ion binding]; metal-binding site
490759005264	active site
490759005265	I-site; other site
490759005266	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759005267	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
490759005268	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
490759005269	putative NAD(P) binding site [chemical binding]; other site
490759005270	putative active site [active]
490759005271	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
490759005272	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
490759005273	GAF domain; Region: GAF; pfam01590
490759005274	PAS domain S-box; Region: sensory_box; TIGR00229
490759005275	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759005276	putative active site [active]
490759005277	heme pocket [chemical binding]; other site
490759005278	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759005279	PAS domain; Region: PAS_9; pfam13426
490759005280	putative active site [active]
490759005281	heme pocket [chemical binding]; other site
490759005282	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759005283	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759005284	metal binding site [ion binding]; metal-binding site
490759005285	active site
490759005286	I-site; other site
490759005287	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759005288	YebG protein; Region: YebG; pfam07130
490759005289	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
490759005290	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
490759005291	active site
490759005292	metal binding site [ion binding]; metal-binding site
490759005293	DNA binding site [nucleotide binding]
490759005294	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759005295	AAA domain; Region: AAA_23; pfam13476
490759005296	Walker A/P-loop; other site
490759005297	ATP binding site [chemical binding]; other site
490759005298	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
490759005299	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
490759005300	MOSC domain; Region: MOSC; pfam03473
490759005301	ABC transporter ATPase component; Reviewed; Region: PRK11147
490759005302	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
490759005303	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
490759005304	ABC transporter; Region: ABC_tran_2; pfam12848
490759005305	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
490759005306	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
490759005307	Ligand Binding Site [chemical binding]; other site
490759005308	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
490759005309	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759005310	substrate binding site [chemical binding]; other site
490759005311	oxyanion hole (OAH) forming residues; other site
490759005312	trimer interface [polypeptide binding]; other site
490759005313	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
490759005314	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
490759005315	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
490759005316	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
490759005317	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
490759005318	dimer interface [polypeptide binding]; other site
490759005319	active site
490759005320	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
490759005321	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
490759005322	active site
490759005323	interdomain interaction site; other site
490759005324	putative metal-binding site [ion binding]; other site
490759005325	nucleotide binding site [chemical binding]; other site
490759005326	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
490759005327	domain I; other site
490759005328	DNA binding groove [nucleotide binding]
490759005329	phosphate binding site [ion binding]; other site
490759005330	domain II; other site
490759005331	domain III; other site
490759005332	nucleotide binding site [chemical binding]; other site
490759005333	catalytic site [active]
490759005334	domain IV; other site
490759005335	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
490759005336	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
490759005337	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
490759005338	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
490759005339	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
490759005340	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
490759005341	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
490759005342	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
490759005343	dimer interface [polypeptide binding]; other site
490759005344	active site
490759005345	citrylCoA binding site [chemical binding]; other site
490759005346	NADH binding [chemical binding]; other site
490759005347	cationic pore residues; other site
490759005348	oxalacetate/citrate binding site [chemical binding]; other site
490759005349	coenzyme A binding site [chemical binding]; other site
490759005350	catalytic triad [active]
490759005351	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
490759005352	Iron-sulfur protein interface; other site
490759005353	proximal quinone binding site [chemical binding]; other site
490759005354	SdhD (CybS) interface [polypeptide binding]; other site
490759005355	proximal heme binding site [chemical binding]; other site
490759005356	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
490759005357	cardiolipin binding site; other site
490759005358	SdhC subunit interface [polypeptide binding]; other site
490759005359	proximal heme binding site [chemical binding]; other site
490759005360	Iron-sulfur protein interface; other site
490759005361	proximal quinone binding site [chemical binding]; other site
490759005362	L-aspartate oxidase; Provisional; Region: PRK06175
490759005363	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675
490759005364	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
490759005365	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
490759005366	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
490759005367	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
490759005368	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
490759005369	TPP-binding site [chemical binding]; other site
490759005370	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
490759005371	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
490759005372	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
490759005373	E3 interaction surface; other site
490759005374	lipoyl attachment site [posttranslational modification]; other site
490759005375	e3 binding domain; Region: E3_binding; pfam02817
490759005376	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
490759005377	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
490759005378	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
490759005379	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759005380	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
490759005381	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
490759005382	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
490759005383	CoA-ligase; Region: Ligase_CoA; pfam00549
490759005384	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
490759005385	CoA binding domain; Region: CoA_binding; pfam02629
490759005386	CoA-ligase; Region: Ligase_CoA; pfam00549
490759005387	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
490759005388	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
490759005389	active site
490759005390	HIGH motif; other site
490759005391	dimer interface [polypeptide binding]; other site
490759005392	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
490759005393	active site
490759005394	KMSKS motif; other site
490759005395	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
490759005396	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
490759005397	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
490759005398	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
490759005399	RNA binding surface [nucleotide binding]; other site
490759005400	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
490759005401	probable active site [active]
490759005402	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759005403	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759005404	metal binding site [ion binding]; metal-binding site
490759005405	active site
490759005406	I-site; other site
490759005407	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759005408	Q-loop/lid; other site
490759005409	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
490759005410	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
490759005411	ABC transporter signature motif; other site
490759005412	Walker B; other site
490759005413	D-loop; other site
490759005414	H-loop/switch region; other site
490759005415	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
490759005416	FtsZ protein binding site [polypeptide binding]; other site
490759005417	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
490759005418	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
490759005419	nucleotide binding pocket [chemical binding]; other site
490759005420	K-X-D-G motif; other site
490759005421	catalytic site [active]
490759005422	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
490759005423	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
490759005424	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
490759005425	Dimer interface [polypeptide binding]; other site
490759005426	BRCT sequence motif; other site
490759005427	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
490759005428	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
490759005429	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
490759005430	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
490759005431	active site
490759005432	FlgN protein; Region: FlgN; pfam05130
490759005433	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
490759005434	SAF-like; Region: SAF_2; pfam13144
490759005435	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
490759005436	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
490759005437	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
490759005438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759005439	active site
490759005440	phosphorylation site [posttranslational modification]
490759005441	intermolecular recognition site; other site
490759005442	dimerization interface [polypeptide binding]; other site
490759005443	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
490759005444	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
490759005445	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
490759005446	Major Facilitator Superfamily; Region: MFS_1; pfam07690
490759005447	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
490759005448	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
490759005449	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
490759005450	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
490759005451	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
490759005452	Isochorismatase family; Region: Isochorismatase; pfam00857
490759005453	catalytic triad [active]
490759005454	dimer interface [polypeptide binding]; other site
490759005455	conserved cis-peptide bond; other site
490759005456	hypothetical protein; Provisional; Region: PRK03641
490759005457	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
490759005458	Gram-negative porin; Region: Porin_4; pfam13609
490759005459	sensor protein PhoQ; Provisional; Region: PRK10815
490759005460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759005461	ATP binding site [chemical binding]; other site
490759005462	Mg2+ binding site [ion binding]; other site
490759005463	G-X-G motif; other site
490759005464	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
490759005465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759005466	active site
490759005467	phosphorylation site [posttranslational modification]
490759005468	intermolecular recognition site; other site
490759005469	dimerization interface [polypeptide binding]; other site
490759005470	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
490759005471	DNA binding site [nucleotide binding]
490759005472	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
490759005473	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
490759005474	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
490759005475	Multicopper oxidase; Region: Cu-oxidase; pfam00394
490759005476	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
490759005477	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
490759005478	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
490759005479	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
490759005480	YHS domain; Region: YHS; pfam04945
490759005481	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
490759005482	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
490759005483	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759005484	motif II; other site
490759005485	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
490759005486	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
490759005487	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
490759005488	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
490759005489	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
490759005490	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
490759005491	CopC domain; Region: CopC; pfam04234
490759005492	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
490759005493	Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154
490759005494	putative homodimer interface [polypeptide binding]; other site
490759005495	putative homotetramer interface [polypeptide binding]; other site
490759005496	putative metal binding site [ion binding]; other site
490759005497	putative homodimer-homodimer interface [polypeptide binding]; other site
490759005498	putative allosteric switch controlling residues; other site
490759005499	hypothetical protein; Provisional; Region: PRK09272
490759005500	Domain of unknown function DUF; Region: DUF204; pfam02659
490759005501	Predicted membrane protein [Function unknown]; Region: COG1971
490759005502	Domain of unknown function DUF; Region: DUF204; pfam02659
490759005503	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
490759005504	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
490759005505	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
490759005506	putative homodimer-homodimer interface [polypeptide binding]; other site
490759005507	putative allosteric switch controlling residues; other site
490759005508	putative metal binding site [ion binding]; other site
490759005509	Outer membrane efflux protein; Region: OEP; pfam02321
490759005510	Outer membrane efflux protein; Region: OEP; pfam02321
490759005511	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
490759005512	HlyD family secretion protein; Region: HlyD_3; pfam13437
490759005513	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
490759005514	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
490759005515	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
490759005516	DctM-like transporters; Region: DctM; pfam06808
490759005517	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
490759005518	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
490759005519	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759005520	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
490759005521	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
490759005522	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
490759005523	active site
490759005524	NAD binding site [chemical binding]; other site
490759005525	metal binding site [ion binding]; metal-binding site
490759005526	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
490759005527	Transcriptional regulators [Transcription]; Region: FadR; COG2186
490759005528	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759005529	DNA-binding site [nucleotide binding]; DNA binding site
490759005530	FCD domain; Region: FCD; pfam07729
490759005531	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759005532	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
490759005533	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759005534	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759005535	metal binding site [ion binding]; metal-binding site
490759005536	active site
490759005537	I-site; other site
490759005538	HAMP domain; Region: HAMP; pfam00672
490759005539	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
490759005540	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759005541	dimer interface [polypeptide binding]; other site
490759005542	putative CheW interface [polypeptide binding]; other site
490759005543	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759005544	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
490759005545	FOG: CBS domain [General function prediction only]; Region: COG0517
490759005546	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759005547	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759005548	metal binding site [ion binding]; metal-binding site
490759005549	active site
490759005550	I-site; other site
490759005551	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759005552	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759005553	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
490759005554	dimerization interface [polypeptide binding]; other site
490759005555	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
490759005556	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
490759005557	active site
490759005558	metal binding site [ion binding]; metal-binding site
490759005559	PAS fold; Region: PAS_4; pfam08448
490759005560	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759005561	putative active site [active]
490759005562	heme pocket [chemical binding]; other site
490759005563	PAS domain S-box; Region: sensory_box; TIGR00229
490759005564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759005565	heme pocket [chemical binding]; other site
490759005566	putative active site [active]
490759005567	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759005568	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759005569	metal binding site [ion binding]; metal-binding site
490759005570	active site
490759005571	I-site; other site
490759005572	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
490759005573	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
490759005574	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
490759005575	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
490759005576	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
490759005577	Uncharacterized conserved protein [Function unknown]; Region: COG2353
490759005578	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
490759005579	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
490759005580	putative NAD(P) binding site [chemical binding]; other site
490759005581	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
490759005582	active site
490759005583	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
490759005584	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
490759005585	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
490759005586	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
490759005587	RibD C-terminal domain; Region: RibD_C; cl17279
490759005588	Predicted permeases [General function prediction only]; Region: COG0679
490759005589	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
490759005590	AzlC protein; Region: AzlC; cl00570
490759005591	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
490759005592	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
490759005593	Phasin protein; Region: Phasin_2; cl11491
490759005594	Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180
490759005595	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
490759005596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759005597	active site
490759005598	phosphorylation site [posttranslational modification]
490759005599	intermolecular recognition site; other site
490759005600	dimerization interface [polypeptide binding]; other site
490759005601	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
490759005602	DNA binding residues [nucleotide binding]
490759005603	dimerization interface [polypeptide binding]; other site
490759005604	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
490759005605	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
490759005606	active site
490759005607	catalytic site [active]
490759005608	putative DNA binding site [nucleotide binding]; other site
490759005609	GIY-YIG motif/motif A; other site
490759005610	metal binding site [ion binding]; metal-binding site
490759005611	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
490759005612	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
490759005613	Protein of unknown function (DUF330); Region: DUF330; cl01135
490759005614	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
490759005615	mce related protein; Region: MCE; pfam02470
490759005616	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
490759005617	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759005618	Walker A/P-loop; other site
490759005619	ATP binding site [chemical binding]; other site
490759005620	Q-loop/lid; other site
490759005621	ABC transporter signature motif; other site
490759005622	Walker B; other site
490759005623	D-loop; other site
490759005624	H-loop/switch region; other site
490759005625	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
490759005626	Permease; Region: Permease; pfam02405
490759005627	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
490759005628	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759005629	Walker A/P-loop; other site
490759005630	ATP binding site [chemical binding]; other site
490759005631	Q-loop/lid; other site
490759005632	ABC transporter signature motif; other site
490759005633	Walker B; other site
490759005634	D-loop; other site
490759005635	H-loop/switch region; other site
490759005636	thiamine ABC transporter, permease protein; Region: thiP; TIGR01253
490759005637	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759005638	dimer interface [polypeptide binding]; other site
490759005639	conserved gate region; other site
490759005640	putative PBP binding loops; other site
490759005641	ABC-ATPase subunit interface; other site
490759005642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759005643	dimer interface [polypeptide binding]; other site
490759005644	conserved gate region; other site
490759005645	putative PBP binding loops; other site
490759005646	ABC-ATPase subunit interface; other site
490759005647	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
490759005648	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
490759005649	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
490759005650	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
490759005651	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
490759005652	C-terminal domain interface [polypeptide binding]; other site
490759005653	GSH binding site (G-site) [chemical binding]; other site
490759005654	dimer interface [polypeptide binding]; other site
490759005655	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
490759005656	dimer interface [polypeptide binding]; other site
490759005657	N-terminal domain interface [polypeptide binding]; other site
490759005658	active site
490759005659	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
490759005660	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
490759005661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
490759005662	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
490759005663	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
490759005664	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
490759005665	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
490759005666	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
490759005667	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
490759005668	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759005669	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759005670	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
490759005671	putative dimerization interface [polypeptide binding]; other site
490759005672	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
490759005673	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
490759005674	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
490759005675	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
490759005676	nucleotide binding site [chemical binding]; other site
490759005677	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
490759005678	FAD binding domain; Region: FAD_binding_4; pfam01565
490759005679	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
490759005680	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
490759005681	type II secretion system protein E; Region: type_II_gspE; TIGR02533
490759005682	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
490759005683	Walker A motif; other site
490759005684	ATP binding site [chemical binding]; other site
490759005685	Walker B motif; other site
490759005686	type II secretion system protein F; Region: GspF; TIGR02120
490759005687	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
490759005688	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
490759005689	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
490759005690	Type II transport protein GspH; Region: GspH; pfam12019
490759005691	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
490759005692	type II secretion system protein I; Region: gspI; TIGR01707
490759005693	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
490759005694	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
490759005695	type II secretion system protein J; Region: gspJ; TIGR01711
490759005696	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
490759005697	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
490759005698	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
490759005699	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
490759005700	GspL periplasmic domain; Region: GspL_C; pfam12693
490759005701	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
490759005702	glutathione reductase; Validated; Region: PRK06116
490759005703	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
490759005704	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759005705	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
490759005706	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759005707	dimer interface [polypeptide binding]; other site
490759005708	phosphorylation site [posttranslational modification]
490759005709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759005710	ATP binding site [chemical binding]; other site
490759005711	Mg2+ binding site [ion binding]; other site
490759005712	G-X-G motif; other site
490759005713	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
490759005714	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
490759005715	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
490759005716	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759005717	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759005718	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
490759005719	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
490759005720	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
490759005721	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
490759005722	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
490759005723	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
490759005724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759005725	dimer interface [polypeptide binding]; other site
490759005726	conserved gate region; other site
490759005727	putative PBP binding loops; other site
490759005728	ABC-ATPase subunit interface; other site
490759005729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759005730	dimer interface [polypeptide binding]; other site
490759005731	conserved gate region; other site
490759005732	putative PBP binding loops; other site
490759005733	ABC-ATPase subunit interface; other site
490759005734	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
490759005735	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
490759005736	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
490759005737	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
490759005738	dimer interface [polypeptide binding]; other site
490759005739	active site
490759005740	CoA binding pocket [chemical binding]; other site
490759005741	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
490759005742	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
490759005743	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
490759005744	Walker A/P-loop; other site
490759005745	ATP binding site [chemical binding]; other site
490759005746	Q-loop/lid; other site
490759005747	ABC transporter signature motif; other site
490759005748	Walker B; other site
490759005749	D-loop; other site
490759005750	H-loop/switch region; other site
490759005751	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
490759005752	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
490759005753	putative peptidase; Provisional; Region: PRK11649
490759005754	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
490759005755	Peptidase family M23; Region: Peptidase_M23; pfam01551
490759005756	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
490759005757	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
490759005758	ABC-ATPase subunit  interface; other site
490759005759	dimer interface [polypeptide binding]; other site
490759005760	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
490759005761	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
490759005762	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
490759005763	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
490759005764	metal binding site [ion binding]; metal-binding site
490759005765	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
490759005766	active site
490759005767	DNA binding site [nucleotide binding]
490759005768	Int/Topo IB signature motif; other site
490759005769	Response regulator receiver domain; Region: Response_reg; pfam00072
490759005770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759005771	active site
490759005772	phosphorylation site [posttranslational modification]
490759005773	intermolecular recognition site; other site
490759005774	dimerization interface [polypeptide binding]; other site
490759005775	PAS domain S-box; Region: sensory_box; TIGR00229
490759005776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759005777	putative active site [active]
490759005778	heme pocket [chemical binding]; other site
490759005779	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759005780	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759005781	metal binding site [ion binding]; metal-binding site
490759005782	active site
490759005783	I-site; other site
490759005784	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759005785	HDOD domain; Region: HDOD; pfam08668
490759005786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759005787	phosphorylation site [posttranslational modification]
490759005788	dimer interface [polypeptide binding]; other site
490759005789	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
490759005790	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759005791	ATP binding site [chemical binding]; other site
490759005792	Mg2+ binding site [ion binding]; other site
490759005793	G-X-G motif; other site
490759005794	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
490759005795	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
490759005796	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
490759005797	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
490759005798	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
490759005799	active site
490759005800	DNA binding site [nucleotide binding]
490759005801	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
490759005802	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
490759005803	Catalytic site [active]
490759005804	hypothetical protein; Provisional; Region: PRK11171
490759005805	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
490759005806	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
490759005807	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759005808	dimer interface [polypeptide binding]; other site
490759005809	conserved gate region; other site
490759005810	putative PBP binding loops; other site
490759005811	ABC-ATPase subunit interface; other site
490759005812	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
490759005813	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
490759005814	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
490759005815	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759005816	Walker A/P-loop; other site
490759005817	ATP binding site [chemical binding]; other site
490759005818	Q-loop/lid; other site
490759005819	ABC transporter signature motif; other site
490759005820	Walker B; other site
490759005821	D-loop; other site
490759005822	H-loop/switch region; other site
490759005823	TOBE domain; Region: TOBE_2; pfam08402
490759005824	Transcriptional regulators [Transcription]; Region: GntR; COG1802
490759005825	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759005826	DNA-binding site [nucleotide binding]; DNA binding site
490759005827	FCD domain; Region: FCD; pfam07729
490759005828	Transcriptional regulators [Transcription]; Region: GntR; COG1802
490759005829	FCD domain; Region: FCD; pfam07729
490759005830	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
490759005831	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
490759005832	putative active site [active]
490759005833	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
490759005834	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
490759005835	active site
490759005836	catalytic site [active]
490759005837	tetramer interface [polypeptide binding]; other site
490759005838	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
490759005839	homotrimer interaction site [polypeptide binding]; other site
490759005840	putative active site [active]
490759005841	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
490759005842	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
490759005843	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
490759005844	hydroxyglutarate oxidase; Provisional; Region: PRK11728
490759005845	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759005846	DctM-like transporters; Region: DctM; pfam06808
490759005847	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
490759005848	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
490759005849	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759005850	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
490759005851	putative dimerization interface [polypeptide binding]; other site
490759005852	HTH-like domain; Region: HTH_21; pfam13276
490759005853	Dynactin p62 family; Region: Dynactin_p62; pfam05502
490759005854	Integrase core domain; Region: rve_3; pfam13683
490759005855	Homeodomain-like domain; Region: HTH_32; pfam13565
490759005856	Integrase core domain; Region: rve; pfam00665
490759005857	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
490759005858	Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379
490759005859	putative active site [active]
490759005860	putative metal binding site [ion binding]; other site
490759005861	Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379
490759005862	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
490759005863	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
490759005864	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
490759005865	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
490759005866	RHS Repeat; Region: RHS_repeat; pfam05593
490759005867	RHS Repeat; Region: RHS_repeat; pfam05593
490759005868	RHS Repeat; Region: RHS_repeat; pfam05593
490759005869	RHS Repeat; Region: RHS_repeat; pfam05593
490759005870	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
490759005871	RHS protein; Region: RHS; pfam03527
490759005872	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
490759005873	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
490759005874	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
490759005875	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
490759005876	putative active site [active]
490759005877	putative NTP binding site [chemical binding]; other site
490759005878	putative nucleic acid binding site [nucleotide binding]; other site
490759005879	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
490759005880	aconitate hydratase; Validated; Region: PRK07229
490759005881	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
490759005882	substrate binding site [chemical binding]; other site
490759005883	ligand binding site [chemical binding]; other site
490759005884	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
490759005885	substrate binding site [chemical binding]; other site
490759005886	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
490759005887	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
490759005888	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
490759005889	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
490759005890	active site
490759005891	dimer interface [polypeptide binding]; other site
490759005892	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
490759005893	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
490759005894	active site
490759005895	FMN binding site [chemical binding]; other site
490759005896	substrate binding site [chemical binding]; other site
490759005897	3Fe-4S cluster binding site [ion binding]; other site
490759005898	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
490759005899	domain interface; other site
490759005900	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
490759005901	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
490759005902	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
490759005903	putative ABC transporter; Region: ycf24; CHL00085
490759005904	FeS assembly ATPase SufC; Region: sufC; TIGR01978
490759005905	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
490759005906	Walker A/P-loop; other site
490759005907	ATP binding site [chemical binding]; other site
490759005908	Q-loop/lid; other site
490759005909	ABC transporter signature motif; other site
490759005910	Walker B; other site
490759005911	D-loop; other site
490759005912	H-loop/switch region; other site
490759005913	FeS assembly protein SufD; Region: sufD; TIGR01981
490759005914	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
490759005915	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
490759005916	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
490759005917	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
490759005918	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
490759005919	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
490759005920	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
490759005921	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
490759005922	Domain of unknown function DUF59; Region: DUF59; cl00941
490759005923	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
490759005924	diphosphomevalonate decarboxylase; Region: PLN02407
490759005925	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
490759005926	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
490759005927	homodimer interface [polypeptide binding]; other site
490759005928	catalytic residues [active]
490759005929	NAD binding site [chemical binding]; other site
490759005930	substrate binding pocket [chemical binding]; other site
490759005931	flexible flap; other site
490759005932	mevalonate kinase; Region: mevalon_kin; TIGR00549
490759005933	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
490759005934	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
490759005935	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
490759005936	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
490759005937	Sel1-like repeats; Region: SEL1; smart00671
490759005938	Sel1-like repeats; Region: SEL1; smart00671
490759005939	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
490759005940	NifU-like domain; Region: NifU; cl00484
490759005941	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
490759005942	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
490759005943	Walker A motif; other site
490759005944	Protein of unknown function (DUF971); Region: DUF971; pfam06155
490759005945	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
490759005946	active site residue [active]
490759005947	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
490759005948	putative GSH binding site [chemical binding]; other site
490759005949	catalytic residues [active]
490759005950	BolA-like protein; Region: BolA; pfam01722
490759005951	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
490759005952	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759005953	substrate binding pocket [chemical binding]; other site
490759005954	membrane-bound complex binding site; other site
490759005955	hinge residues; other site
490759005956	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
490759005957	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759005958	conserved gate region; other site
490759005959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759005960	dimer interface [polypeptide binding]; other site
490759005961	conserved gate region; other site
490759005962	putative PBP binding loops; other site
490759005963	ABC-ATPase subunit interface; other site
490759005964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759005965	dimer interface [polypeptide binding]; other site
490759005966	conserved gate region; other site
490759005967	putative PBP binding loops; other site
490759005968	ABC-ATPase subunit interface; other site
490759005969	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
490759005970	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
490759005971	Walker A/P-loop; other site
490759005972	ATP binding site [chemical binding]; other site
490759005973	Q-loop/lid; other site
490759005974	ABC transporter signature motif; other site
490759005975	Walker B; other site
490759005976	D-loop; other site
490759005977	H-loop/switch region; other site
490759005978	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
490759005979	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
490759005980	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759005981	dimer interface [polypeptide binding]; other site
490759005982	phosphorylation site [posttranslational modification]
490759005983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759005984	ATP binding site [chemical binding]; other site
490759005985	Mg2+ binding site [ion binding]; other site
490759005986	G-X-G motif; other site
490759005987	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
490759005988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759005989	active site
490759005990	phosphorylation site [posttranslational modification]
490759005991	intermolecular recognition site; other site
490759005992	dimerization interface [polypeptide binding]; other site
490759005993	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
490759005994	DNA binding site [nucleotide binding]
490759005995	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
490759005996	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
490759005997	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
490759005998	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
490759005999	Ligand binding site; other site
490759006000	Putative Catalytic site; other site
490759006001	DXD motif; other site
490759006002	Predicted membrane protein [Function unknown]; Region: COG2246
490759006003	GtrA-like protein; Region: GtrA; pfam04138
490759006004	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
490759006005	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
490759006006	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
490759006007	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
490759006008	FAD binding pocket [chemical binding]; other site
490759006009	FAD binding motif [chemical binding]; other site
490759006010	phosphate binding motif [ion binding]; other site
490759006011	beta-alpha-beta structure motif; other site
490759006012	NAD binding pocket [chemical binding]; other site
490759006013	sensor protein QseC; Provisional; Region: PRK10337
490759006014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759006015	ATP binding site [chemical binding]; other site
490759006016	Mg2+ binding site [ion binding]; other site
490759006017	G-X-G motif; other site
490759006018	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
490759006019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759006020	active site
490759006021	phosphorylation site [posttranslational modification]
490759006022	intermolecular recognition site; other site
490759006023	dimerization interface [polypeptide binding]; other site
490759006024	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
490759006025	DNA binding site [nucleotide binding]
490759006026	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
490759006027	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
490759006028	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide.  Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201
490759006029	FAD binding pocket [chemical binding]; other site
490759006030	FAD binding motif [chemical binding]; other site
490759006031	catalytic residues [active]
490759006032	NAD binding pocket [chemical binding]; other site
490759006033	phosphate binding motif [ion binding]; other site
490759006034	beta-alpha-beta structure motif; other site
490759006035	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
490759006036	arsenical-resistance protein; Region: acr3; TIGR00832
490759006037	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
490759006038	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
490759006039	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
490759006040	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
490759006041	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
490759006042	Fatty acid desaturase; Region: FA_desaturase; pfam00487
490759006043	putative di-iron ligands [ion binding]; other site
490759006044	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
490759006045	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
490759006046	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
490759006047	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
490759006048	malate:quinone oxidoreductase; Validated; Region: PRK05257
490759006049	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
490759006050	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
490759006051	cyanate transporter; Region: CynX; TIGR00896
490759006052	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759006053	Protein of unknown function, DUF479; Region: DUF479; cl01203
490759006054	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
490759006055	putative hydrolase; Provisional; Region: PRK11460
490759006056	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
490759006057	DNA replication terminus site-binding protein (Ter protein); Region: Ter; pfam05472
490759006058	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
490759006059	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
490759006060	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
490759006061	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
490759006062	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
490759006063	putative acyl-acceptor binding pocket; other site
490759006064	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
490759006065	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
490759006066	ATP binding site [chemical binding]; other site
490759006067	putative Mg++ binding site [ion binding]; other site
490759006068	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759006069	nucleotide binding region [chemical binding]; other site
490759006070	ATP-binding site [chemical binding]; other site
490759006071	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
490759006072	HRDC domain; Region: HRDC; pfam00570
490759006073	Predicted amidohydrolase [General function prediction only]; Region: COG0388
490759006074	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
490759006075	putative active site [active]
490759006076	catalytic triad [active]
490759006077	putative dimer interface [polypeptide binding]; other site
490759006078	Y-family of DNA polymerases; Region: PolY; cl12025
490759006079	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
490759006080	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759006081	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
490759006082	Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709
490759006083	dimerization interface [polypeptide binding]; other site
490759006084	putative ATP binding site [chemical binding]; other site
490759006085	rusticyanin; Region: rusti_cyanin; TIGR03095
490759006086	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
490759006087	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
490759006088	Walker A/P-loop; other site
490759006089	ATP binding site [chemical binding]; other site
490759006090	Q-loop/lid; other site
490759006091	ABC transporter signature motif; other site
490759006092	Walker B; other site
490759006093	D-loop; other site
490759006094	H-loop/switch region; other site
490759006095	ABC-2 type transporter; Region: ABC2_membrane; cl17235
490759006096	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
490759006097	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
490759006098	enoyl-CoA hydratase; Validated; Region: PRK08139
490759006099	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759006100	substrate binding site [chemical binding]; other site
490759006101	oxyanion hole (OAH) forming residues; other site
490759006102	trimer interface [polypeptide binding]; other site
490759006103	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
490759006104	tellurium resistance terB-like protein; Region: terB_like; cd07177
490759006105	metal binding site [ion binding]; metal-binding site
490759006106	Alternative oxidase; Region: AOX; pfam01786
490759006107	dinuclear metal binding motif [ion binding]; other site
490759006108	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
490759006109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759006110	putative substrate translocation pore; other site
490759006111	Protein of unknown function (DUF1569); Region: DUF1569; pfam07606
490759006112	NHL repeat; Region: NHL; pfam01436
490759006113	Major royal jelly protein; Region: MRJP; pfam03022
490759006114	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
490759006115	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
490759006116	putative ligand binding site [chemical binding]; other site
490759006117	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
490759006118	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
490759006119	TM-ABC transporter signature motif; other site
490759006120	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
490759006121	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
490759006122	TM-ABC transporter signature motif; other site
490759006123	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759006124	Walker A/P-loop; other site
490759006125	ATP binding site [chemical binding]; other site
490759006126	ABC transporter; Region: ABC_tran; pfam00005
490759006127	Q-loop/lid; other site
490759006128	ABC transporter signature motif; other site
490759006129	Walker B; other site
490759006130	D-loop; other site
490759006131	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
490759006132	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
490759006133	Walker A/P-loop; other site
490759006134	ATP binding site [chemical binding]; other site
490759006135	Q-loop/lid; other site
490759006136	ABC transporter signature motif; other site
490759006137	Walker B; other site
490759006138	D-loop; other site
490759006139	H-loop/switch region; other site
490759006140	Predicted amidohydrolase [General function prediction only]; Region: COG0388
490759006141	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580
490759006142	putative active site [active]
490759006143	catalytic triad [active]
490759006144	putative dimer interface [polypeptide binding]; other site
490759006145	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
490759006146	putative effector binding pocket; other site
490759006147	dimerization interface [polypeptide binding]; other site
490759006148	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759006149	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759006150	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
490759006151	dimerization interface [polypeptide binding]; other site
490759006152	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
490759006153	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
490759006154	putative C-terminal domain interface [polypeptide binding]; other site
490759006155	putative GSH binding site (G-site) [chemical binding]; other site
490759006156	putative dimer interface [polypeptide binding]; other site
490759006157	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
490759006158	putative substrate binding pocket (H-site) [chemical binding]; other site
490759006159	putative N-terminal domain interface [polypeptide binding]; other site
490759006160	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
490759006161	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
490759006162	tetramer interface [polypeptide binding]; other site
490759006163	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759006164	catalytic residue [active]
490759006165	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759006166	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
490759006167	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759006168	dimerization interface [polypeptide binding]; other site
490759006169	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
490759006170	Predicted amidohydrolase [General function prediction only]; Region: COG0388
490759006171	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
490759006172	putative active site [active]
490759006173	catalytic triad [active]
490759006174	putative dimer interface [polypeptide binding]; other site
490759006175	hypothetical protein; Provisional; Region: PRK08317
490759006176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759006177	S-adenosylmethionine binding site [chemical binding]; other site
490759006178	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759006179	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759006180	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759006181	dimerization interface [polypeptide binding]; other site
490759006182	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
490759006183	active site
490759006184	NTP binding site [chemical binding]; other site
490759006185	nucleic acid binding site [nucleotide binding]; other site
490759006186	NIPSNAP; Region: NIPSNAP; pfam07978
490759006187	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
490759006188	active site
490759006189	Int/Topo IB signature motif; other site
490759006190	DNA binding site [nucleotide binding]
490759006191	UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186
490759006192	Methyltransferase domain; Region: Methyltransf_23; pfam13489
490759006193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759006194	S-adenosylmethionine binding site [chemical binding]; other site
490759006195	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
490759006196	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
490759006197	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
490759006198	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
490759006199	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
490759006200	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
490759006201	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759006202	Walker A/P-loop; other site
490759006203	ATP binding site [chemical binding]; other site
490759006204	ABC transporter signature motif; other site
490759006205	Walker B; other site
490759006206	D-loop; other site
490759006207	H-loop/switch region; other site
490759006208	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
490759006209	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759006210	Walker A/P-loop; other site
490759006211	ATP binding site [chemical binding]; other site
490759006212	Q-loop/lid; other site
490759006213	ABC transporter signature motif; other site
490759006214	Walker B; other site
490759006215	D-loop; other site
490759006216	H-loop/switch region; other site
490759006217	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
490759006218	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
490759006219	putative active site [active]
490759006220	metal binding site [ion binding]; metal-binding site
490759006221	Uncharacterized conserved protein [Function unknown]; Region: COG3268
490759006222	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
490759006223	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
490759006224	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
490759006225	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
490759006226	Ligand binding site [chemical binding]; other site
490759006227	Electron transfer flavoprotein domain; Region: ETF; pfam01012
490759006228	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
490759006229	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
490759006230	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
490759006231	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
490759006232	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
490759006233	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
490759006234	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
490759006235	catalytic core [active]
490759006236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
490759006237	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
490759006238	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
490759006239	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
490759006240	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
490759006241	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
490759006242	anti sigma factor interaction site; other site
490759006243	regulatory phosphorylation site [posttranslational modification]; other site
490759006244	Response regulator receiver domain; Region: Response_reg; pfam00072
490759006245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759006246	active site
490759006247	phosphorylation site [posttranslational modification]
490759006248	dimerization interface [polypeptide binding]; other site
490759006249	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
490759006250	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
490759006251	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
490759006252	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
490759006253	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
490759006254	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
490759006255	putative di-iron ligands [ion binding]; other site
490759006256	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
490759006257	SnoaL-like domain; Region: SnoaL_2; pfam12680
490759006258	short chain dehydrogenase; Provisional; Region: PRK06101
490759006259	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759006260	NAD(P) binding site [chemical binding]; other site
490759006261	active site
490759006262	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
490759006263	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
490759006264	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
490759006265	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
490759006266	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
490759006267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759006268	S-adenosylmethionine binding site [chemical binding]; other site
490759006269	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
490759006270	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
490759006271	putative catalytic site [active]
490759006272	putative phosphate binding site [ion binding]; other site
490759006273	active site
490759006274	metal binding site A [ion binding]; metal-binding site
490759006275	DNA binding site [nucleotide binding]
490759006276	putative AP binding site [nucleotide binding]; other site
490759006277	putative metal binding site B [ion binding]; other site
490759006278	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
490759006279	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
490759006280	Bacterial transcriptional repressor; Region: TetR; pfam13972
490759006281	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
490759006282	Putative phosphatase (DUF442); Region: DUF442; cl17385
490759006283	ferrochelatase; Reviewed; Region: hemH; PRK00035
490759006284	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
490759006285	C-terminal domain interface [polypeptide binding]; other site
490759006286	active site
490759006287	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
490759006288	active site
490759006289	N-terminal domain interface [polypeptide binding]; other site
490759006290	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
490759006291	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
490759006292	Transcriptional regulator [Transcription]; Region: IclR; COG1414
490759006293	Bacterial transcriptional regulator; Region: IclR; pfam01614
490759006294	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
490759006295	DctM-like transporters; Region: DctM; pfam06808
490759006296	Domain of unknown function (DUF1850); Region: DUF1850; cl01950
490759006297	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
490759006298	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
490759006299	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
490759006300	putative active site [active]
490759006301	putative metal binding site [ion binding]; other site
490759006302	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
490759006303	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
490759006304	oxidoreductase; Validated; Region: PRK05717
490759006305	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759006306	NAD(P) binding site [chemical binding]; other site
490759006307	active site
490759006308	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
490759006309	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
490759006310	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
490759006311	DsrE/DsrF-like family; Region: DrsE; cl00672
490759006312	DsrH like protein; Region: DsrH; cl17347
490759006313	DsrC like protein; Region: DsrC; pfam04358
490759006314	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
490759006315	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
490759006316	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
490759006317	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
490759006318	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
490759006319	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
490759006320	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
490759006321	substrate binding pocket [chemical binding]; other site
490759006322	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
490759006323	B12 binding site [chemical binding]; other site
490759006324	cobalt ligand [ion binding]; other site
490759006325	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
490759006326	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
490759006327	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
490759006328	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
490759006329	NADP binding site [chemical binding]; other site
490759006330	dimer interface [polypeptide binding]; other site
490759006331	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
490759006332	putative inner membrane peptidase; Provisional; Region: PRK11778
490759006333	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
490759006334	tandem repeat interface [polypeptide binding]; other site
490759006335	oligomer interface [polypeptide binding]; other site
490759006336	active site residues [active]
490759006337	SCP-2 sterol transfer family; Region: SCP2; pfam02036
490759006338	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
490759006339	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
490759006340	active site
490759006341	catalytic site [active]
490759006342	substrate binding site [chemical binding]; other site
490759006343	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
490759006344	RNA/DNA hybrid binding site [nucleotide binding]; other site
490759006345	active site
490759006346	Methyltransferase domain; Region: Methyltransf_11; pfam08241
490759006347	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
490759006348	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
490759006349	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
490759006350	N-acetyl-D-glucosamine binding site [chemical binding]; other site
490759006351	catalytic residue [active]
490759006352	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
490759006353	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
490759006354	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
490759006355	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
490759006356	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
490759006357	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
490759006358	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
490759006359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759006360	dimer interface [polypeptide binding]; other site
490759006361	conserved gate region; other site
490759006362	putative PBP binding loops; other site
490759006363	ABC-ATPase subunit interface; other site
490759006364	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
490759006365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759006366	dimer interface [polypeptide binding]; other site
490759006367	conserved gate region; other site
490759006368	ABC-ATPase subunit interface; other site
490759006369	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
490759006370	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
490759006371	Walker A/P-loop; other site
490759006372	ATP binding site [chemical binding]; other site
490759006373	Q-loop/lid; other site
490759006374	ABC transporter signature motif; other site
490759006375	Walker B; other site
490759006376	D-loop; other site
490759006377	H-loop/switch region; other site
490759006378	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
490759006379	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
490759006380	Walker A/P-loop; other site
490759006381	ATP binding site [chemical binding]; other site
490759006382	Q-loop/lid; other site
490759006383	ABC transporter signature motif; other site
490759006384	Walker B; other site
490759006385	D-loop; other site
490759006386	H-loop/switch region; other site
490759006387	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
490759006388	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
490759006389	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
490759006390	NAD binding site [chemical binding]; other site
490759006391	homotetramer interface [polypeptide binding]; other site
490759006392	homodimer interface [polypeptide binding]; other site
490759006393	substrate binding site [chemical binding]; other site
490759006394	active site
490759006395	PilZ domain; Region: PilZ; pfam07238
490759006396	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
490759006397	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
490759006398	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
490759006399	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
490759006400	seryl-tRNA synthetase; Provisional; Region: PRK05431
490759006401	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
490759006402	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
490759006403	dimer interface [polypeptide binding]; other site
490759006404	active site
490759006405	motif 1; other site
490759006406	motif 2; other site
490759006407	motif 3; other site
490759006408	recombination factor protein RarA; Reviewed; Region: PRK13342
490759006409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759006410	Walker A motif; other site
490759006411	ATP binding site [chemical binding]; other site
490759006412	Walker B motif; other site
490759006413	arginine finger; other site
490759006414	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
490759006415	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
490759006416	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
490759006417	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
490759006418	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
490759006419	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
490759006420	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
490759006421	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
490759006422	homodimer interface [polypeptide binding]; other site
490759006423	substrate-cofactor binding pocket; other site
490759006424	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759006425	catalytic residue [active]
490759006426	amidophosphoribosyltransferase; Provisional; Region: PRK09246
490759006427	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
490759006428	active site
490759006429	tetramer interface [polypeptide binding]; other site
490759006430	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
490759006431	active site
490759006432	Colicin V production protein; Region: Colicin_V; cl00567
490759006433	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
490759006434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
490759006435	Sporulation related domain; Region: SPOR; pfam05036
490759006436	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
490759006437	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
490759006438	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
490759006439	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
490759006440	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
490759006441	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
490759006442	active site
490759006443	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
490759006444	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
490759006445	dimerization interface 3.5A [polypeptide binding]; other site
490759006446	active site
490759006447	FimV N-terminal domain; Region: FimV_core; TIGR03505
490759006448	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
490759006449	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
490759006450	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
490759006451	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
490759006452	tartrate dehydrogenase; Region: TTC; TIGR02089
490759006453	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
490759006454	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
490759006455	substrate binding site [chemical binding]; other site
490759006456	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
490759006457	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
490759006458	substrate binding site [chemical binding]; other site
490759006459	ligand binding site [chemical binding]; other site
490759006460	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759006461	putative substrate translocation pore; other site
490759006462	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
490759006463	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
490759006464	Tetramer interface [polypeptide binding]; other site
490759006465	active site
490759006466	FMN-binding site [chemical binding]; other site
490759006467	HemK family putative methylases; Region: hemK_fam; TIGR00536
490759006468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759006469	S-adenosylmethionine binding site [chemical binding]; other site
490759006470	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
490759006471	active site
490759006472	nucleophile elbow; other site
490759006473	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
490759006474	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
490759006475	PGAP1-like protein; Region: PGAP1; pfam07819
490759006476	PilZ domain; Region: PilZ; cl01260
490759006477	DNA polymerase III subunit delta'; Validated; Region: PRK05707
490759006478	DNA polymerase III subunit delta'; Validated; Region: PRK08485
490759006479	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
490759006480	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
490759006481	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
490759006482	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
490759006483	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551
490759006484	Protein of unknown function DUF58; Region: DUF58; pfam01882
490759006485	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
490759006486	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
490759006487	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
490759006488	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759006489	motif II; other site
490759006490	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
490759006491	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759006492	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
490759006493	substrate binding site [chemical binding]; other site
490759006494	dimerization interface [polypeptide binding]; other site
490759006495	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
490759006496	DEAD/DEAH box helicase; Region: DEAD; pfam00270
490759006497	DEAD_2; Region: DEAD_2; pfam06733
490759006498	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
490759006499	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
490759006500	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759006501	Walker A motif; other site
490759006502	ATP binding site [chemical binding]; other site
490759006503	Walker B motif; other site
490759006504	arginine finger; other site
490759006505	VacJ like lipoprotein; Region: VacJ; cl01073
490759006506	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
490759006507	active site
490759006508	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
490759006509	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
490759006510	dimer interface [polypeptide binding]; other site
490759006511	active site
490759006512	CoA binding pocket [chemical binding]; other site
490759006513	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
490759006514	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
490759006515	ATP binding site [chemical binding]; other site
490759006516	putative Mg++ binding site [ion binding]; other site
490759006517	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759006518	nucleotide binding region [chemical binding]; other site
490759006519	ATP-binding site [chemical binding]; other site
490759006520	Helicase associated domain (HA2); Region: HA2; pfam04408
490759006521	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
490759006522	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
490759006523	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
490759006524	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
490759006525	acyl-activating enzyme (AAE) consensus motif; other site
490759006526	putative AMP binding site [chemical binding]; other site
490759006527	putative active site [active]
490759006528	putative CoA binding site [chemical binding]; other site
490759006529	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
490759006530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759006531	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
490759006532	Walker A motif; other site
490759006533	ATP binding site [chemical binding]; other site
490759006534	Walker B motif; other site
490759006535	arginine finger; other site
490759006536	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
490759006537	metal ion-dependent adhesion site (MIDAS); other site
490759006538	TIGR03503 family protein; Region: TIGR03503
490759006539	hypothetical protein; Provisional; Region: PRK05170
490759006540	YcgL domain; Region: YcgL; pfam05166
490759006541	ribonuclease D; Region: rnd; TIGR01388
490759006542	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
490759006543	catalytic site [active]
490759006544	putative active site [active]
490759006545	putative substrate binding site [chemical binding]; other site
490759006546	HRDC domain; Region: HRDC; pfam00570
490759006547	recombination protein RecR; Reviewed; Region: recR; PRK00076
490759006548	RecR protein; Region: RecR; pfam02132
490759006549	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
490759006550	putative active site [active]
490759006551	putative metal-binding site [ion binding]; other site
490759006552	tetramer interface [polypeptide binding]; other site
490759006553	hypothetical protein; Validated; Region: PRK00153
490759006554	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
490759006555	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759006556	Walker A motif; other site
490759006557	ATP binding site [chemical binding]; other site
490759006558	Walker B motif; other site
490759006559	arginine finger; other site
490759006560	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
490759006561	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
490759006562	GAF domain; Region: GAF_3; pfam13492
490759006563	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759006564	ATP binding site [chemical binding]; other site
490759006565	Mg2+ binding site [ion binding]; other site
490759006566	G-X-G motif; other site
490759006567	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
490759006568	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759006569	active site
490759006570	phosphorylation site [posttranslational modification]
490759006571	intermolecular recognition site; other site
490759006572	dimerization interface [polypeptide binding]; other site
490759006573	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759006574	Walker A motif; other site
490759006575	ATP binding site [chemical binding]; other site
490759006576	Walker B motif; other site
490759006577	arginine finger; other site
490759006578	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759006579	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759006580	Tetratricopeptide repeat; Region: TPR_16; pfam13432
490759006581	binding surface
490759006582	TPR motif; other site
490759006583	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759006584	TPR motif; other site
490759006585	binding surface
490759006586	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
490759006587	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
490759006588	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
490759006589	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
490759006590	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
490759006591	Substrate binding site; other site
490759006592	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
490759006593	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
490759006594	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
490759006595	putative ADP-binding pocket [chemical binding]; other site
490759006596	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
490759006597	PA14 domain; Region: PA14; cl08459
490759006598	PA14 domain; Region: PA14; cl08459
490759006599	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
490759006600	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
490759006601	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
490759006602	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
490759006603	active site
490759006604	Transposase; Region: HTH_Tnp_1; cl17663
490759006605	Integrase core domain; Region: rve; pfam00665
490759006606	Integrase core domain; Region: rve_3; pfam13683
490759006607	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
490759006608	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
490759006609	Active Sites [active]
490759006610	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
490759006611	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
490759006612	CysD dimerization site [polypeptide binding]; other site
490759006613	G1 box; other site
490759006614	putative GEF interaction site [polypeptide binding]; other site
490759006615	GTP/Mg2+ binding site [chemical binding]; other site
490759006616	Switch I region; other site
490759006617	G2 box; other site
490759006618	G3 box; other site
490759006619	Switch II region; other site
490759006620	G4 box; other site
490759006621	G5 box; other site
490759006622	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
490759006623	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
490759006624	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
490759006625	ligand-binding site [chemical binding]; other site
490759006626	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
490759006627	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
490759006628	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
490759006629	TrkA-C domain; Region: TrkA_C; pfam02080
490759006630	TrkA-C domain; Region: TrkA_C; pfam02080
490759006631	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
490759006632	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
490759006633	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
490759006634	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
490759006635	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
490759006636	O-Antigen ligase; Region: Wzy_C; cl04850
490759006637	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
490759006638	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
490759006639	active site
490759006640	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
490759006641	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
490759006642	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
490759006643	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
490759006644	active site
490759006645	Methyltransferase domain; Region: Methyltransf_12; pfam08242
490759006646	Methyltransferase domain; Region: Methyltransf_23; pfam13489
490759006647	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
490759006648	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
490759006649	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
490759006650	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
490759006651	dimer interface [polypeptide binding]; other site
490759006652	active site
490759006653	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
490759006654	Ligand Binding Site [chemical binding]; other site
490759006655	Molecular Tunnel; other site
490759006656	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
490759006657	Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935
490759006658	putative active site [active]
490759006659	putative catalytic site [active]
490759006660	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
490759006661	putative ADP-binding pocket [chemical binding]; other site
490759006662	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
490759006663	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
490759006664	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
490759006665	active site
490759006666	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
490759006667	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
490759006668	active site
490759006669	trimer interface [polypeptide binding]; other site
490759006670	substrate binding site [chemical binding]; other site
490759006671	CoA binding site [chemical binding]; other site
490759006672	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
490759006673	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
490759006674	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
490759006675	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
490759006676	uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016
490759006677	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
490759006678	Chain length determinant protein; Region: Wzz; cl15801
490759006679	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
490759006680	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
490759006681	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
490759006682	SLBB domain; Region: SLBB; pfam10531
490759006683	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
490759006684	Bacterial sugar transferase; Region: Bac_transf; pfam02397
490759006685	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
490759006686	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
490759006687	putative active site [active]
490759006688	putative catalytic site [active]
490759006689	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
490759006690	AAA ATPase domain; Region: AAA_16; pfam13191
490759006691	Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236
490759006692	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
490759006693	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
490759006694	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
490759006695	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
490759006696	2-methylcitrate dehydratase; Region: prpD; TIGR02330
490759006697	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
490759006698	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
490759006699	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
490759006700	substrate binding site [chemical binding]; other site
490759006701	ligand binding site [chemical binding]; other site
490759006702	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
490759006703	substrate binding site [chemical binding]; other site
490759006704	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
490759006705	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
490759006706	dimer interface [polypeptide binding]; other site
490759006707	active site
490759006708	citrylCoA binding site [chemical binding]; other site
490759006709	oxalacetate/citrate binding site [chemical binding]; other site
490759006710	coenzyme A binding site [chemical binding]; other site
490759006711	catalytic triad [active]
490759006712	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
490759006713	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
490759006714	tetramer interface [polypeptide binding]; other site
490759006715	active site
490759006716	Mg2+/Mn2+ binding site [ion binding]; other site
490759006717	Transcriptional regulators [Transcription]; Region: GntR; COG1802
490759006718	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759006719	DNA-binding site [nucleotide binding]; DNA binding site
490759006720	FCD domain; Region: FCD; pfam07729
490759006721	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
490759006722	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
490759006723	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
490759006724	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
490759006725	Ligand binding site; other site
490759006726	DXD motif; other site
490759006727	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
490759006728	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
490759006729	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
490759006730	active site
490759006731	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
490759006732	tetramer interface; other site
490759006733	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
490759006734	DNA binding site [nucleotide binding]
490759006735	active site
490759006736	Int/Topo IB signature motif; other site
490759006737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759006738	PAS fold; Region: PAS_3; pfam08447
490759006739	putative active site [active]
490759006740	heme pocket [chemical binding]; other site
490759006741	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
490759006742	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
490759006743	homotrimer interaction site [polypeptide binding]; other site
490759006744	putative active site [active]
490759006745	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759006746	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759006747	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
490759006748	dimerization interface [polypeptide binding]; other site
490759006749	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759006750	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759006751	substrate binding pocket [chemical binding]; other site
490759006752	membrane-bound complex binding site; other site
490759006753	hinge residues; other site
490759006754	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
490759006755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759006756	ABC-ATPase subunit interface; other site
490759006757	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
490759006758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759006759	dimer interface [polypeptide binding]; other site
490759006760	conserved gate region; other site
490759006761	putative PBP binding loops; other site
490759006762	ABC-ATPase subunit interface; other site
490759006763	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
490759006764	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
490759006765	Walker A/P-loop; other site
490759006766	ATP binding site [chemical binding]; other site
490759006767	Q-loop/lid; other site
490759006768	ABC transporter signature motif; other site
490759006769	Walker B; other site
490759006770	D-loop; other site
490759006771	H-loop/switch region; other site
490759006772	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
490759006773	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
490759006774	allantoate amidohydrolase; Reviewed; Region: PRK09290
490759006775	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
490759006776	active site
490759006777	metal binding site [ion binding]; metal-binding site
490759006778	dimer interface [polypeptide binding]; other site
490759006779	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
490759006780	metal binding site [ion binding]; metal-binding site
490759006781	succinic semialdehyde dehydrogenase; Region: PLN02278
490759006782	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
490759006783	tetramerization interface [polypeptide binding]; other site
490759006784	NAD(P) binding site [chemical binding]; other site
490759006785	catalytic residues [active]
490759006786	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
490759006787	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
490759006788	Walker A/P-loop; other site
490759006789	ATP binding site [chemical binding]; other site
490759006790	Q-loop/lid; other site
490759006791	ABC transporter signature motif; other site
490759006792	Walker B; other site
490759006793	D-loop; other site
490759006794	H-loop/switch region; other site
490759006795	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
490759006796	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
490759006797	Walker A/P-loop; other site
490759006798	ATP binding site [chemical binding]; other site
490759006799	Q-loop/lid; other site
490759006800	ABC transporter signature motif; other site
490759006801	Walker B; other site
490759006802	D-loop; other site
490759006803	H-loop/switch region; other site
490759006804	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
490759006805	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
490759006806	TM-ABC transporter signature motif; other site
490759006807	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
490759006808	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
490759006809	TM-ABC transporter signature motif; other site
490759006810	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
490759006811	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
490759006812	putative ligand binding site [chemical binding]; other site
490759006813	acyl-CoA synthetase; Validated; Region: PRK08162
490759006814	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
490759006815	acyl-activating enzyme (AAE) consensus motif; other site
490759006816	putative active site [active]
490759006817	AMP binding site [chemical binding]; other site
490759006818	putative CoA binding site [chemical binding]; other site
490759006819	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
490759006820	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
490759006821	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
490759006822	dimer interface [polypeptide binding]; other site
490759006823	acyl-activating enzyme (AAE) consensus motif; other site
490759006824	putative active site [active]
490759006825	AMP binding site [chemical binding]; other site
490759006826	putative CoA binding site [chemical binding]; other site
490759006827	Propionate catabolism activator; Region: PrpR_N; pfam06506
490759006828	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
490759006829	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759006830	Walker A motif; other site
490759006831	ATP binding site [chemical binding]; other site
490759006832	Walker B motif; other site
490759006833	arginine finger; other site
490759006834	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759006835	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
490759006836	Phosphotransferase enzyme family; Region: APH; pfam01636
490759006837	putative active site [active]
490759006838	putative substrate binding site [chemical binding]; other site
490759006839	ATP binding site [chemical binding]; other site
490759006840	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
490759006841	catalytic core [active]
490759006842	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
490759006843	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759006844	active site
490759006845	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
490759006846	classical (c) SDRs; Region: SDR_c; cd05233
490759006847	NAD(P) binding site [chemical binding]; other site
490759006848	active site
490759006849	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
490759006850	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
490759006851	active site
490759006852	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
490759006853	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
490759006854	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759006855	dimer interface [polypeptide binding]; other site
490759006856	conserved gate region; other site
490759006857	putative PBP binding loops; other site
490759006858	ABC-ATPase subunit interface; other site
490759006859	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
490759006860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759006861	dimer interface [polypeptide binding]; other site
490759006862	conserved gate region; other site
490759006863	putative PBP binding loops; other site
490759006864	ABC-ATPase subunit interface; other site
490759006865	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
490759006866	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
490759006867	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
490759006868	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
490759006869	Walker A/P-loop; other site
490759006870	ATP binding site [chemical binding]; other site
490759006871	Q-loop/lid; other site
490759006872	ABC transporter signature motif; other site
490759006873	Walker B; other site
490759006874	D-loop; other site
490759006875	H-loop/switch region; other site
490759006876	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
490759006877	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
490759006878	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
490759006879	Walker A/P-loop; other site
490759006880	ATP binding site [chemical binding]; other site
490759006881	Q-loop/lid; other site
490759006882	ABC transporter signature motif; other site
490759006883	Walker B; other site
490759006884	D-loop; other site
490759006885	H-loop/switch region; other site
490759006886	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
490759006887	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
490759006888	nucleoside/Zn binding site; other site
490759006889	dimer interface [polypeptide binding]; other site
490759006890	catalytic motif [active]
490759006891	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
490759006892	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
490759006893	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
490759006894	Amidase; Region: Amidase; pfam01425
490759006895	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
490759006896	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
490759006897	active site
490759006898	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
490759006899	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759006900	dimer interface [polypeptide binding]; other site
490759006901	conserved gate region; other site
490759006902	putative PBP binding loops; other site
490759006903	ABC-ATPase subunit interface; other site
490759006904	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
490759006905	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
490759006906	Walker A/P-loop; other site
490759006907	ATP binding site [chemical binding]; other site
490759006908	Q-loop/lid; other site
490759006909	ABC transporter signature motif; other site
490759006910	Walker B; other site
490759006911	D-loop; other site
490759006912	H-loop/switch region; other site
490759006913	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
490759006914	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759006915	substrate binding pocket [chemical binding]; other site
490759006916	membrane-bound complex binding site; other site
490759006917	hinge residues; other site
490759006918	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
490759006919	allantoate amidohydrolase; Reviewed; Region: PRK12890
490759006920	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
490759006921	active site
490759006922	metal binding site [ion binding]; metal-binding site
490759006923	dimer interface [polypeptide binding]; other site
490759006924	Transcriptional regulators [Transcription]; Region: FadR; COG2186
490759006925	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759006926	DNA-binding site [nucleotide binding]; DNA binding site
490759006927	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
490759006928	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
490759006929	Amidase; Region: Amidase; pfam01425
490759006930	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
490759006931	Protein of unknown function (DUF3830); Region: DUF3830; pfam12903
490759006932	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759006933	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759006934	active site
490759006935	I-site; other site
490759006936	metal binding site [ion binding]; metal-binding site
490759006937	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759006938	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
490759006939	EamA-like transporter family; Region: EamA; pfam00892
490759006940	fructokinase; Reviewed; Region: PRK09557
490759006941	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
490759006942	nucleotide binding site [chemical binding]; other site
490759006943	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
490759006944	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
490759006945	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
490759006946	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
490759006947	Walker A/P-loop; other site
490759006948	ATP binding site [chemical binding]; other site
490759006949	Q-loop/lid; other site
490759006950	ABC transporter signature motif; other site
490759006951	Walker B; other site
490759006952	D-loop; other site
490759006953	H-loop/switch region; other site
490759006954	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
490759006955	FtsX-like permease family; Region: FtsX; pfam02687
490759006956	macrolide transporter subunit MacA; Provisional; Region: PRK11578
490759006957	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
490759006958	HlyD family secretion protein; Region: HlyD_3; pfam13437
490759006959	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
490759006960	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
490759006961	active site
490759006962	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
490759006963	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
490759006964	putative NAD(P) binding site [chemical binding]; other site
490759006965	active site
490759006966	putative substrate binding site [chemical binding]; other site
490759006967	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
490759006968	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
490759006969	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
490759006970	ATP binding site [chemical binding]; other site
490759006971	active site
490759006972	substrate binding site [chemical binding]; other site
490759006973	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
490759006974	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
490759006975	dihydrodipicolinate synthase; Region: dapA; TIGR00674
490759006976	dimer interface [polypeptide binding]; other site
490759006977	active site
490759006978	catalytic residue [active]
490759006979	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
490759006980	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
490759006981	catalytic triad [active]
490759006982	Domain of unknown function DUF20; Region: UPF0118; pfam01594
490759006983	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
490759006984	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
490759006985	CPxP  motif; other site
490759006986	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
490759006987	Peptidase family M48; Region: Peptidase_M48; pfam01435
490759006988	quinolinate synthetase; Provisional; Region: PRK09375
490759006989	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
490759006990	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
490759006991	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
490759006992	ligand binding site [chemical binding]; other site
490759006993	translocation protein TolB; Provisional; Region: tolB; PRK00178
490759006994	TolB amino-terminal domain; Region: TolB_N; pfam04052
490759006995	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
490759006996	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
490759006997	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
490759006998	TolA protein; Region: tolA_full; TIGR02794
490759006999	TonB C terminal; Region: TonB_2; pfam13103
490759007000	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
490759007001	TolR protein; Region: tolR; TIGR02801
490759007002	TolQ protein; Region: tolQ; TIGR02796
490759007003	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
490759007004	active site
490759007005	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
490759007006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759007007	Walker A motif; other site
490759007008	ATP binding site [chemical binding]; other site
490759007009	Walker B motif; other site
490759007010	arginine finger; other site
490759007011	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
490759007012	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
490759007013	RuvA N terminal domain; Region: RuvA_N; pfam01330
490759007014	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
490759007015	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
490759007016	dimer interface [polypeptide binding]; other site
490759007017	putative DNA-binding cleft [nucleotide binding]; other site
490759007018	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
490759007019	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
490759007020	dimer interface [polypeptide binding]; other site
490759007021	anticodon binding site; other site
490759007022	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
490759007023	homodimer interface [polypeptide binding]; other site
490759007024	motif 1; other site
490759007025	active site
490759007026	motif 2; other site
490759007027	GAD domain; Region: GAD; pfam02938
490759007028	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
490759007029	active site
490759007030	motif 3; other site
490759007031	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
490759007032	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
490759007033	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
490759007034	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
490759007035	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
490759007036	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
490759007037	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
490759007038	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
490759007039	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
490759007040	NAD binding site [chemical binding]; other site
490759007041	homodimer interface [polypeptide binding]; other site
490759007042	active site
490759007043	substrate binding site [chemical binding]; other site
490759007044	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
490759007045	nucleoside/Zn binding site; other site
490759007046	dimer interface [polypeptide binding]; other site
490759007047	catalytic motif [active]
490759007048	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
490759007049	ATP-grasp domain; Region: ATP-grasp_4; cl17255
490759007050	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
490759007051	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
490759007052	putative metal binding site [ion binding]; other site
490759007053	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
490759007054	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
490759007055	putative metal binding site [ion binding]; other site
490759007056	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
490759007057	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
490759007058	putative metal binding site [ion binding]; other site
490759007059	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
490759007060	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
490759007061	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
490759007062	tellurite resistance protein terB; Region: terB; cd07176
490759007063	putative metal binding site [ion binding]; other site
490759007064	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
490759007065	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
490759007066	putative metal binding site [ion binding]; other site
490759007067	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
490759007068	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
490759007069	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
490759007070	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
490759007071	GMP synthase; Reviewed; Region: guaA; PRK00074
490759007072	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
490759007073	AMP/PPi binding site [chemical binding]; other site
490759007074	candidate oxyanion hole; other site
490759007075	catalytic triad [active]
490759007076	potential glutamine specificity residues [chemical binding]; other site
490759007077	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
490759007078	ATP Binding subdomain [chemical binding]; other site
490759007079	Ligand Binding sites [chemical binding]; other site
490759007080	Dimerization subdomain; other site
490759007081	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
490759007082	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
490759007083	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
490759007084	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
490759007085	active site
490759007086	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
490759007087	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
490759007088	generic binding surface II; other site
490759007089	generic binding surface I; other site
490759007090	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
490759007091	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
490759007092	acyl-activating enzyme (AAE) consensus motif; other site
490759007093	putative AMP binding site [chemical binding]; other site
490759007094	putative active site [active]
490759007095	putative CoA binding site [chemical binding]; other site
490759007096	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
490759007097	DNA-binding site [nucleotide binding]; DNA binding site
490759007098	RNA-binding motif; other site
490759007099	2-isopropylmalate synthase; Validated; Region: PRK03739
490759007100	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
490759007101	active site
490759007102	catalytic residues [active]
490759007103	metal binding site [ion binding]; metal-binding site
490759007104	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
490759007105	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
490759007106	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
490759007107	putative DNA binding site [nucleotide binding]; other site
490759007108	putative Zn2+ binding site [ion binding]; other site
490759007109	AsnC family; Region: AsnC_trans_reg; pfam01037
490759007110	prolyl-tRNA synthetase; Provisional; Region: PRK09194
490759007111	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
490759007112	dimer interface [polypeptide binding]; other site
490759007113	motif 1; other site
490759007114	active site
490759007115	motif 2; other site
490759007116	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
490759007117	putative deacylase active site [active]
490759007118	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
490759007119	active site
490759007120	motif 3; other site
490759007121	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
490759007122	anticodon binding site; other site
490759007123	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
490759007124	FAD binding domain; Region: FAD_binding_4; pfam01565
490759007125	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
490759007126	Low molecular weight phosphatase family; Region: LMWPc; cd00115
490759007127	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
490759007128	active site
490759007129	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
490759007130	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
490759007131	Ligand binding site; other site
490759007132	oligomer interface; other site
490759007133	Trm112p-like protein; Region: Trm112p; cl01066
490759007134	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
490759007135	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
490759007136	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
490759007137	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
490759007138	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
490759007139	Walker A/P-loop; other site
490759007140	ATP binding site [chemical binding]; other site
490759007141	Q-loop/lid; other site
490759007142	ABC transporter signature motif; other site
490759007143	Walker B; other site
490759007144	D-loop; other site
490759007145	H-loop/switch region; other site
490759007146	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
490759007147	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
490759007148	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
490759007149	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
490759007150	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
490759007151	Competence protein; Region: Competence; pfam03772
490759007152	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
490759007153	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
490759007154	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
490759007155	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
490759007156	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
490759007157	Walker A/P-loop; other site
490759007158	ATP binding site [chemical binding]; other site
490759007159	Q-loop/lid; other site
490759007160	ABC transporter signature motif; other site
490759007161	Walker B; other site
490759007162	D-loop; other site
490759007163	H-loop/switch region; other site
490759007164	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
490759007165	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
490759007166	FtsX-like permease family; Region: FtsX; pfam02687
490759007167	PilZ domain; Region: PilZ; pfam07238
490759007168	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
490759007169	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
490759007170	MoxR-like ATPases [General function prediction only]; Region: COG0714
490759007171	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759007172	Walker A motif; other site
490759007173	ATP binding site [chemical binding]; other site
490759007174	Walker B motif; other site
490759007175	arginine finger; other site
490759007176	thioredoxin reductase; Provisional; Region: PRK10262
490759007177	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
490759007178	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759007179	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
490759007180	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
490759007181	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
490759007182	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
490759007183	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
490759007184	rRNA binding site [nucleotide binding]; other site
490759007185	predicted 30S ribosome binding site; other site
490759007186	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
490759007187	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
490759007188	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
490759007189	Clp amino terminal domain; Region: Clp_N; pfam02861
490759007190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759007191	Walker A motif; other site
490759007192	ATP binding site [chemical binding]; other site
490759007193	Walker B motif; other site
490759007194	arginine finger; other site
490759007195	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759007196	Walker A motif; other site
490759007197	ATP binding site [chemical binding]; other site
490759007198	Walker B motif; other site
490759007199	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
490759007200	Uncharacterized conserved protein [Function unknown]; Region: COG2127
490759007201	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
490759007202	DNA-binding site [nucleotide binding]; DNA binding site
490759007203	RNA-binding motif; other site
490759007204	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
490759007205	pseudouridine synthase; Region: TIGR00093
490759007206	active site
490759007207	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
490759007208	nudix motif; other site
490759007209	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
490759007210	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
490759007211	Ligand Binding Site [chemical binding]; other site
490759007212	putative lysogenization regulator; Reviewed; Region: PRK00218
490759007213	adenylosuccinate lyase; Provisional; Region: PRK09285
490759007214	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
490759007215	tetramer interface [polypeptide binding]; other site
490759007216	active site
490759007217	Uncharacterized conserved protein [Function unknown]; Region: COG2850
490759007218	Cupin-like domain; Region: Cupin_8; pfam13621
490759007219	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
490759007220	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
490759007221	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
490759007222	Coenzyme A binding pocket [chemical binding]; other site
490759007223	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759007224	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759007225	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
490759007226	substrate binding pocket [chemical binding]; other site
490759007227	dimerization interface [polypeptide binding]; other site
490759007228	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
490759007229	catalytic residues [active]
490759007230	dimer interface [polypeptide binding]; other site
490759007231	aminotransferase AlaT; Validated; Region: PRK09265
490759007232	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
490759007233	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759007234	homodimer interface [polypeptide binding]; other site
490759007235	catalytic residue [active]
490759007236	heat shock protein HtpX; Provisional; Region: PRK05457
490759007237	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
490759007238	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759007239	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759007240	dimerization interface [polypeptide binding]; other site
490759007241	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
490759007242	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
490759007243	ligand binding site [chemical binding]; other site
490759007244	NAD binding site [chemical binding]; other site
490759007245	catalytic site [active]
490759007246	homodimer interface [polypeptide binding]; other site
490759007247	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
490759007248	DEAD-like helicases superfamily; Region: DEXDc; smart00487
490759007249	ATP binding site [chemical binding]; other site
490759007250	Mg++ binding site [ion binding]; other site
490759007251	motif III; other site
490759007252	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759007253	nucleotide binding region [chemical binding]; other site
490759007254	ATP-binding site [chemical binding]; other site
490759007255	Protein of unknown function, DUF462; Region: DUF462; pfam04315
490759007256	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
490759007257	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
490759007258	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
490759007259	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
490759007260	DsbD alpha interface [polypeptide binding]; other site
490759007261	catalytic residues [active]
490759007262	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
490759007263	CPxP  motif; other site
490759007264	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
490759007265	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
490759007266	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
490759007267	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
490759007268	Low-spin heme binding site [chemical binding]; other site
490759007269	Putative water exit pathway; other site
490759007270	Binuclear center (active site) [active]
490759007271	Putative proton exit pathway; other site
490759007272	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
490759007273	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
490759007274	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
490759007275	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
490759007276	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
490759007277	Cytochrome c; Region: Cytochrom_C; pfam00034
490759007278	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
490759007279	4Fe-4S binding domain; Region: Fer4_5; pfam12801
490759007280	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
490759007281	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
490759007282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
490759007283	FixH; Region: FixH; pfam05751
490759007284	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
490759007285	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
490759007286	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
490759007287	metal-binding site [ion binding]
490759007288	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
490759007289	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759007290	motif II; other site
490759007291	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
490759007292	Family description; Region: DsbD_2; pfam13386
490759007293	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
490759007294	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
490759007295	Ligand Binding Site [chemical binding]; other site
490759007296	DNA-J related protein; Region: DNAJ_related; pfam12339
490759007297	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
490759007298	HSP70 interaction site [polypeptide binding]; other site
490759007299	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973
490759007300	putative active site [active]
490759007301	putative metal binding site [ion binding]; other site
490759007302	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
490759007303	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
490759007304	FOG: CBS domain [General function prediction only]; Region: COG0517
490759007305	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
490759007306	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759007307	PAS domain; Region: PAS_9; pfam13426
490759007308	putative active site [active]
490759007309	heme pocket [chemical binding]; other site
490759007310	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759007311	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759007312	metal binding site [ion binding]; metal-binding site
490759007313	active site
490759007314	I-site; other site
490759007315	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
490759007316	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
490759007317	DNA binding site [nucleotide binding]
490759007318	active site
490759007319	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
490759007320	HAMP domain; Region: HAMP; pfam00672
490759007321	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759007322	dimer interface [polypeptide binding]; other site
490759007323	putative CheW interface [polypeptide binding]; other site
490759007324	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
490759007325	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
490759007326	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
490759007327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759007328	putative PBP binding loops; other site
490759007329	dimer interface [polypeptide binding]; other site
490759007330	ABC-ATPase subunit interface; other site
490759007331	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
490759007332	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
490759007333	Walker A/P-loop; other site
490759007334	ATP binding site [chemical binding]; other site
490759007335	Q-loop/lid; other site
490759007336	ABC transporter signature motif; other site
490759007337	Walker B; other site
490759007338	D-loop; other site
490759007339	H-loop/switch region; other site
490759007340	TOBE domain; Region: TOBE_2; pfam08402
490759007341	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
490759007342	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
490759007343	Walker A/P-loop; other site
490759007344	ATP binding site [chemical binding]; other site
490759007345	Q-loop/lid; other site
490759007346	ABC transporter signature motif; other site
490759007347	Walker B; other site
490759007348	D-loop; other site
490759007349	H-loop/switch region; other site
490759007350	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
490759007351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759007352	Walker A motif; other site
490759007353	ATP binding site [chemical binding]; other site
490759007354	Walker B motif; other site
490759007355	arginine finger; other site
490759007356	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759007357	glycerol kinase; Provisional; Region: glpK; PRK00047
490759007358	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
490759007359	N- and C-terminal domain interface [polypeptide binding]; other site
490759007360	active site
490759007361	MgATP binding site [chemical binding]; other site
490759007362	catalytic site [active]
490759007363	metal binding site [ion binding]; metal-binding site
490759007364	glycerol binding site [chemical binding]; other site
490759007365	homotetramer interface [polypeptide binding]; other site
490759007366	homodimer interface [polypeptide binding]; other site
490759007367	FBP binding site [chemical binding]; other site
490759007368	protein IIAGlc interface [polypeptide binding]; other site
490759007369	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
490759007370	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
490759007371	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
490759007372	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
490759007373	phosphogluconate dehydratase; Validated; Region: PRK09054
490759007374	6-phosphogluconate dehydratase; Region: edd; TIGR01196
490759007375	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
490759007376	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
490759007377	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
490759007378	pyruvate kinase; Provisional; Region: PRK05826
490759007379	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
490759007380	domain interfaces; other site
490759007381	active site
490759007382	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
490759007383	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
490759007384	active site
490759007385	intersubunit interface [polypeptide binding]; other site
490759007386	catalytic residue [active]
490759007387	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
490759007388	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
490759007389	putative active site [active]
490759007390	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
490759007391	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
490759007392	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
490759007393	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
490759007394	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
490759007395	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
490759007396	putative active site [active]
490759007397	SurA N-terminal domain; Region: SurA_N_3; cl07813
490759007398	periplasmic folding chaperone; Provisional; Region: PRK10788
490759007399	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
490759007400	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
490759007401	IHF dimer interface [polypeptide binding]; other site
490759007402	IHF - DNA interface [nucleotide binding]; other site
490759007403	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
490759007404	Found in ATP-dependent protease La (LON); Region: LON; smart00464
490759007405	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759007406	Walker A motif; other site
490759007407	ATP binding site [chemical binding]; other site
490759007408	Walker B motif; other site
490759007409	arginine finger; other site
490759007410	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
490759007411	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
490759007412	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
490759007413	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759007414	Walker A motif; other site
490759007415	ATP binding site [chemical binding]; other site
490759007416	Walker B motif; other site
490759007417	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
490759007418	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
490759007419	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
490759007420	oligomer interface [polypeptide binding]; other site
490759007421	active site residues [active]
490759007422	trigger factor; Provisional; Region: tig; PRK01490
490759007423	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
490759007424	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
490759007425	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
490759007426	active site 2 [active]
490759007427	active site 1 [active]
490759007428	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
490759007429	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
490759007430	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
490759007431	homodimer interface [polypeptide binding]; other site
490759007432	NADP binding site [chemical binding]; other site
490759007433	substrate binding site [chemical binding]; other site
490759007434	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
490759007435	malonyl-CoA synthase; Validated; Region: PRK07514
490759007436	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
490759007437	acyl-activating enzyme (AAE) consensus motif; other site
490759007438	active site
490759007439	AMP binding site [chemical binding]; other site
490759007440	CoA binding site [chemical binding]; other site
490759007441	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
490759007442	DctM-like transporters; Region: DctM; pfam06808
490759007443	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
490759007444	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
490759007445	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
490759007446	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759007447	Transcriptional regulators [Transcription]; Region: FadR; COG2186
490759007448	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759007449	DNA-binding site [nucleotide binding]; DNA binding site
490759007450	FCD domain; Region: FCD; pfam07729
490759007451	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
490759007452	active site
490759007453	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
490759007454	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
490759007455	active site
490759007456	HIGH motif; other site
490759007457	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
490759007458	KMSKS motif; other site
490759007459	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
490759007460	tRNA binding surface [nucleotide binding]; other site
490759007461	anticodon binding site; other site
490759007462	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
490759007463	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
490759007464	active site
490759007465	HIGH motif; other site
490759007466	nucleotide binding site [chemical binding]; other site
490759007467	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
490759007468	KMSKS motif; other site
490759007469	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
490759007470	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
490759007471	substrate binding site [chemical binding]; other site
490759007472	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
490759007473	putative active site [active]
490759007474	putative metal binding site [ion binding]; other site
490759007475	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
490759007476	dimer interaction site [polypeptide binding]; other site
490759007477	substrate-binding tunnel; other site
490759007478	active site
490759007479	catalytic site [active]
490759007480	substrate binding site [chemical binding]; other site
490759007481	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
490759007482	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
490759007483	NAD(P) binding site [chemical binding]; other site
490759007484	homotetramer interface [polypeptide binding]; other site
490759007485	homodimer interface [polypeptide binding]; other site
490759007486	active site
490759007487	putative S-transferase; Provisional; Region: PRK11752
490759007488	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
490759007489	C-terminal domain interface [polypeptide binding]; other site
490759007490	GSH binding site (G-site) [chemical binding]; other site
490759007491	dimer interface [polypeptide binding]; other site
490759007492	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
490759007493	dimer interface [polypeptide binding]; other site
490759007494	N-terminal domain interface [polypeptide binding]; other site
490759007495	active site
490759007496	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
490759007497	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
490759007498	FAD binding pocket [chemical binding]; other site
490759007499	FAD binding motif [chemical binding]; other site
490759007500	phosphate binding motif [ion binding]; other site
490759007501	beta-alpha-beta structure motif; other site
490759007502	NAD binding pocket [chemical binding]; other site
490759007503	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
490759007504	active site
490759007505	dinuclear metal binding site [ion binding]; other site
490759007506	dimerization interface [polypeptide binding]; other site
490759007507	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
490759007508	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
490759007509	substrate binding site [chemical binding]; other site
490759007510	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
490759007511	substrate binding site [chemical binding]; other site
490759007512	ligand binding site [chemical binding]; other site
490759007513	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
490759007514	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
490759007515	Na binding site [ion binding]; other site
490759007516	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
490759007517	Proline dehydrogenase; Region: Pro_dh; pfam01619
490759007518	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
490759007519	Glutamate binding site [chemical binding]; other site
490759007520	NAD binding site [chemical binding]; other site
490759007521	catalytic residues [active]
490759007522	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
490759007523	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
490759007524	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
490759007525	thymidylate kinase; Validated; Region: tmk; PRK00698
490759007526	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
490759007527	TMP-binding site; other site
490759007528	ATP-binding site [chemical binding]; other site
490759007529	YceG-like family; Region: YceG; pfam02618
490759007530	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
490759007531	dimerization interface [polypeptide binding]; other site
490759007532	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
490759007533	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
490759007534	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759007535	catalytic residue [active]
490759007536	acyl carrier protein; Provisional; Region: acpP; PRK00982
490759007537	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
490759007538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759007539	NAD(P) binding site [chemical binding]; other site
490759007540	active site
490759007541	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
490759007542	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
490759007543	putative phosphate acyltransferase; Provisional; Region: PRK05331
490759007544	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
490759007545	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
490759007546	Maf-like protein; Region: Maf; pfam02545
490759007547	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
490759007548	active site
490759007549	dimer interface [polypeptide binding]; other site
490759007550	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
490759007551	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
490759007552	tandem repeat interface [polypeptide binding]; other site
490759007553	oligomer interface [polypeptide binding]; other site
490759007554	active site residues [active]
490759007555	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
490759007556	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759007557	active site
490759007558	motif I; other site
490759007559	motif II; other site
490759007560	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
490759007561	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
490759007562	RNA binding surface [nucleotide binding]; other site
490759007563	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
490759007564	active site
490759007565	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
490759007566	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
490759007567	homodimer interface [polypeptide binding]; other site
490759007568	oligonucleotide binding site [chemical binding]; other site
490759007569	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
490759007570	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
490759007571	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
490759007572	active site
490759007573	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
490759007574	YciI-like protein; Reviewed; Region: PRK11370
490759007575	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
490759007576	Bacterial SH3 domain; Region: SH3_3; pfam08239
490759007577	PilZ domain; Region: PilZ; pfam07238
490759007578	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
490759007579	phosphoenolpyruvate synthase; Validated; Region: PRK06464
490759007580	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
490759007581	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
490759007582	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
490759007583	PEP synthetase regulatory protein; Provisional; Region: PRK05339
490759007584	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
490759007585	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
490759007586	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
490759007587	Peptidase M16C associated; Region: M16C_assoc; pfam08367
490759007588	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
490759007589	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
490759007590	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
490759007591	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
490759007592	HIGH motif; other site
490759007593	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
490759007594	active site
490759007595	KMSKS motif; other site
490759007596	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
490759007597	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
490759007598	metal binding site [ion binding]; metal-binding site
490759007599	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
490759007600	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
490759007601	homodimer interface [polypeptide binding]; other site
490759007602	substrate-cofactor binding pocket; other site
490759007603	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759007604	catalytic residue [active]
490759007605	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
490759007606	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
490759007607	non-specific DNA binding site [nucleotide binding]; other site
490759007608	salt bridge; other site
490759007609	sequence-specific DNA binding site [nucleotide binding]; other site
490759007610	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
490759007611	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
490759007612	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
490759007613	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
490759007614	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
490759007615	Walker A/P-loop; other site
490759007616	ATP binding site [chemical binding]; other site
490759007617	Q-loop/lid; other site
490759007618	ABC transporter signature motif; other site
490759007619	Walker B; other site
490759007620	D-loop; other site
490759007621	H-loop/switch region; other site
490759007622	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
490759007623	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
490759007624	HlyD family secretion protein; Region: HlyD_3; pfam13437
490759007625	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
490759007626	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
490759007627	Beta-Casp domain; Region: Beta-Casp; smart01027
490759007628	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
490759007629	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
490759007630	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
490759007631	NAD(P) binding site [chemical binding]; other site
490759007632	homodimer interface [polypeptide binding]; other site
490759007633	substrate binding site [chemical binding]; other site
490759007634	active site
490759007635	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
490759007636	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
490759007637	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
490759007638	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
490759007639	putative trimer interface [polypeptide binding]; other site
490759007640	putative CoA binding site [chemical binding]; other site
490759007641	Bacterial sugar transferase; Region: Bac_transf; pfam02397
490759007642	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
490759007643	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
490759007644	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
490759007645	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
490759007646	active site
490759007647	homodimer interface [polypeptide binding]; other site
490759007648	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759007649	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
490759007650	NAD(P) binding site [chemical binding]; other site
490759007651	active site
490759007652	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
490759007653	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
490759007654	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
490759007655	NAD(P) binding site [chemical binding]; other site
490759007656	homodimer interface [polypeptide binding]; other site
490759007657	substrate binding site [chemical binding]; other site
490759007658	active site
490759007659	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
490759007660	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
490759007661	active site
490759007662	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
490759007663	Integrase core domain; Region: rve; pfam00665
490759007664	Integrase core domain; Region: rve_3; pfam13683
490759007665	Integrase core domain; Region: rve; pfam00665
490759007666	Transposase; Region: HTH_Tnp_1; cl17663
490759007667	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
490759007668	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
490759007669	Probable Catalytic site; other site
490759007670	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
490759007671	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
490759007672	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
490759007673	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
490759007674	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
490759007675	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
490759007676	substrate binding site; other site
490759007677	tetramer interface; other site
490759007678	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
490759007679	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
490759007680	NADP binding site [chemical binding]; other site
490759007681	active site
490759007682	putative substrate binding site [chemical binding]; other site
490759007683	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
490759007684	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
490759007685	NAD binding site [chemical binding]; other site
490759007686	substrate binding site [chemical binding]; other site
490759007687	homodimer interface [polypeptide binding]; other site
490759007688	active site
490759007689	Chain length determinant protein; Region: Wzz; cl15801
490759007690	Chain length determinant protein; Region: Wzz; pfam02706
490759007691	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
490759007692	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
490759007693	SLBB domain; Region: SLBB; pfam10531
490759007694	SLBB domain; Region: SLBB; pfam10531
490759007695	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
490759007696	HipA-like N-terminal domain; Region: HipA_N; pfam07805
490759007697	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
490759007698	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
490759007699	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
490759007700	IHF dimer interface [polypeptide binding]; other site
490759007701	IHF - DNA interface [nucleotide binding]; other site
490759007702	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
490759007703	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
490759007704	putative tRNA-binding site [nucleotide binding]; other site
490759007705	B3/4 domain; Region: B3_4; pfam03483
490759007706	tRNA synthetase B5 domain; Region: B5; smart00874
490759007707	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
490759007708	dimer interface [polypeptide binding]; other site
490759007709	motif 1; other site
490759007710	motif 3; other site
490759007711	motif 2; other site
490759007712	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
490759007713	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
490759007714	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
490759007715	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
490759007716	dimer interface [polypeptide binding]; other site
490759007717	motif 1; other site
490759007718	active site
490759007719	motif 2; other site
490759007720	motif 3; other site
490759007721	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
490759007722	23S rRNA binding site [nucleotide binding]; other site
490759007723	L21 binding site [polypeptide binding]; other site
490759007724	L13 binding site [polypeptide binding]; other site
490759007725	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
490759007726	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
490759007727	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
490759007728	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
490759007729	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
490759007730	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
490759007731	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
490759007732	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
490759007733	active site
490759007734	dimer interface [polypeptide binding]; other site
490759007735	motif 1; other site
490759007736	motif 2; other site
490759007737	motif 3; other site
490759007738	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
490759007739	anticodon binding site; other site
490759007740	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
490759007741	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
490759007742	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
490759007743	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
490759007744	aminopeptidase N; Provisional; Region: pepN; PRK14015
490759007745	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
490759007746	active site
490759007747	Zn binding site [ion binding]; other site
490759007748	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
490759007749	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
490759007750	Rhomboid family; Region: Rhomboid; pfam01694
490759007751	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
490759007752	active site
490759007753	metal binding site [ion binding]; metal-binding site
490759007754	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
490759007755	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
490759007756	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
490759007757	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
490759007758	active site
490759007759	FMN binding site [chemical binding]; other site
490759007760	2,4-decadienoyl-CoA binding site; other site
490759007761	catalytic residue [active]
490759007762	4Fe-4S cluster binding site [ion binding]; other site
490759007763	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
490759007764	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
490759007765	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
490759007766	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
490759007767	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
490759007768	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
490759007769	Walker A/P-loop; other site
490759007770	ATP binding site [chemical binding]; other site
490759007771	Q-loop/lid; other site
490759007772	ABC transporter signature motif; other site
490759007773	Walker B; other site
490759007774	D-loop; other site
490759007775	H-loop/switch region; other site
490759007776	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
490759007777	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
490759007778	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759007779	dimer interface [polypeptide binding]; other site
490759007780	conserved gate region; other site
490759007781	putative PBP binding loops; other site
490759007782	ABC-ATPase subunit interface; other site
490759007783	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759007784	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759007785	substrate binding pocket [chemical binding]; other site
490759007786	membrane-bound complex binding site; other site
490759007787	hinge residues; other site
490759007788	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
490759007789	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
490759007790	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
490759007791	Response regulator receiver domain; Region: Response_reg; pfam00072
490759007792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759007793	active site
490759007794	phosphorylation site [posttranslational modification]
490759007795	intermolecular recognition site; other site
490759007796	dimerization interface [polypeptide binding]; other site
490759007797	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
490759007798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759007799	putative active site [active]
490759007800	heme pocket [chemical binding]; other site
490759007801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759007802	dimer interface [polypeptide binding]; other site
490759007803	phosphorylation site [posttranslational modification]
490759007804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759007805	ATP binding site [chemical binding]; other site
490759007806	Mg2+ binding site [ion binding]; other site
490759007807	G-X-G motif; other site
490759007808	response regulator FixJ; Provisional; Region: fixJ; PRK09390
490759007809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759007810	active site
490759007811	phosphorylation site [posttranslational modification]
490759007812	intermolecular recognition site; other site
490759007813	dimerization interface [polypeptide binding]; other site
490759007814	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
490759007815	DNA binding residues [nucleotide binding]
490759007816	dimerization interface [polypeptide binding]; other site
490759007817	AAA domain; Region: AAA_32; pfam13654
490759007818	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
490759007819	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
490759007820	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
490759007821	recombinase A; Provisional; Region: recA; PRK09354
490759007822	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
490759007823	hexamer interface [polypeptide binding]; other site
490759007824	Walker A motif; other site
490759007825	ATP binding site [chemical binding]; other site
490759007826	Walker B motif; other site
490759007827	Competence-damaged protein; Region: CinA; cl00666
490759007828	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
490759007829	MutS domain I; Region: MutS_I; pfam01624
490759007830	MutS domain II; Region: MutS_II; pfam05188
490759007831	MutS domain III; Region: MutS_III; pfam05192
490759007832	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
490759007833	Walker A/P-loop; other site
490759007834	ATP binding site [chemical binding]; other site
490759007835	Q-loop/lid; other site
490759007836	ABC transporter signature motif; other site
490759007837	Walker B; other site
490759007838	D-loop; other site
490759007839	H-loop/switch region; other site
490759007840	acyl-CoA synthetase; Validated; Region: PRK08162
490759007841	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
490759007842	acyl-activating enzyme (AAE) consensus motif; other site
490759007843	putative active site [active]
490759007844	AMP binding site [chemical binding]; other site
490759007845	putative CoA binding site [chemical binding]; other site
490759007846	PAS domain S-box; Region: sensory_box; TIGR00229
490759007847	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759007848	putative active site [active]
490759007849	heme pocket [chemical binding]; other site
490759007850	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759007851	dimer interface [polypeptide binding]; other site
490759007852	phosphorylation site [posttranslational modification]
490759007853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759007854	ATP binding site [chemical binding]; other site
490759007855	Mg2+ binding site [ion binding]; other site
490759007856	G-X-G motif; other site
490759007857	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
490759007858	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759007859	active site
490759007860	phosphorylation site [posttranslational modification]
490759007861	intermolecular recognition site; other site
490759007862	dimerization interface [polypeptide binding]; other site
490759007863	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
490759007864	DNA binding residues [nucleotide binding]
490759007865	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
490759007866	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759007867	DNA-binding site [nucleotide binding]; DNA binding site
490759007868	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
490759007869	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759007870	homodimer interface [polypeptide binding]; other site
490759007871	catalytic residue [active]
490759007872	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
490759007873	HI0933-like protein; Region: HI0933_like; pfam03486
490759007874	hydroxyglutarate oxidase; Provisional; Region: PRK11728
490759007875	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
490759007876	Ligand Binding Site [chemical binding]; other site
490759007877	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
490759007878	Ligand Binding Site [chemical binding]; other site
490759007879	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
490759007880	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
490759007881	Sulfate transporter family; Region: Sulfate_transp; pfam00916
490759007882	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
490759007883	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
490759007884	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
490759007885	putative metal binding site [ion binding]; other site
490759007886	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
490759007887	HSP70 interaction site [polypeptide binding]; other site
490759007888	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
490759007889	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
490759007890	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
490759007891	HlyD family secretion protein; Region: HlyD_3; pfam13437
490759007892	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
490759007893	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
490759007894	PYR/PP interface [polypeptide binding]; other site
490759007895	dimer interface [polypeptide binding]; other site
490759007896	TPP binding site [chemical binding]; other site
490759007897	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
490759007898	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
490759007899	TPP-binding site [chemical binding]; other site
490759007900	dimer interface [polypeptide binding]; other site
490759007901	ACT domain; Region: ACT_5; pfam13710
490759007902	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
490759007903	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
490759007904	dimer interface [polypeptide binding]; other site
490759007905	active site
490759007906	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
490759007907	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759007908	active site
490759007909	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
490759007910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759007911	NAD(P) binding site [chemical binding]; other site
490759007912	active site
490759007913	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
490759007914	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
490759007915	DNA binding residues [nucleotide binding]
490759007916	putative dimer interface [polypeptide binding]; other site
490759007917	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
490759007918	isovaleryl-CoA dehydrogenase; Region: PLN02519
490759007919	substrate binding site [chemical binding]; other site
490759007920	FAD binding site [chemical binding]; other site
490759007921	catalytic base [active]
490759007922	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
490759007923	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
490759007924	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759007925	enoyl-CoA hydratase; Provisional; Region: PRK05995
490759007926	substrate binding site [chemical binding]; other site
490759007927	oxyanion hole (OAH) forming residues; other site
490759007928	trimer interface [polypeptide binding]; other site
490759007929	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
490759007930	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
490759007931	ATP-grasp domain; Region: ATP-grasp_4; cl17255
490759007932	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
490759007933	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
490759007934	carboxyltransferase (CT) interaction site; other site
490759007935	biotinylation site [posttranslational modification]; other site
490759007936	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
490759007937	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
490759007938	active site
490759007939	catalytic residues [active]
490759007940	metal binding site [ion binding]; metal-binding site
490759007941	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
490759007942	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
490759007943	AMP-binding domain protein; Validated; Region: PRK08315
490759007944	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
490759007945	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
490759007946	acyl-activating enzyme (AAE) consensus motif; other site
490759007947	putative AMP binding site [chemical binding]; other site
490759007948	putative active site [active]
490759007949	putative CoA binding site [chemical binding]; other site
490759007950	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
490759007951	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
490759007952	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
490759007953	aspartate racemase; Region: asp_race; TIGR00035
490759007954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
490759007955	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
490759007956	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
490759007957	TM-ABC transporter signature motif; other site
490759007958	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
490759007959	TM-ABC transporter signature motif; other site
490759007960	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
490759007961	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
490759007962	putative ligand binding site [chemical binding]; other site
490759007963	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
490759007964	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
490759007965	Walker A/P-loop; other site
490759007966	ATP binding site [chemical binding]; other site
490759007967	Q-loop/lid; other site
490759007968	ABC transporter signature motif; other site
490759007969	Walker B; other site
490759007970	D-loop; other site
490759007971	H-loop/switch region; other site
490759007972	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
490759007973	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
490759007974	Walker A/P-loop; other site
490759007975	ATP binding site [chemical binding]; other site
490759007976	Q-loop/lid; other site
490759007977	ABC transporter signature motif; other site
490759007978	Walker B; other site
490759007979	D-loop; other site
490759007980	H-loop/switch region; other site
490759007981	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
490759007982	CoenzymeA binding site [chemical binding]; other site
490759007983	subunit interaction site [polypeptide binding]; other site
490759007984	PHB binding site; other site
490759007985	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
490759007986	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
490759007987	acyl-activating enzyme (AAE) consensus motif; other site
490759007988	AMP binding site [chemical binding]; other site
490759007989	active site
490759007990	CoA binding site [chemical binding]; other site
490759007991	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
490759007992	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759007993	Walker A motif; other site
490759007994	ATP binding site [chemical binding]; other site
490759007995	Walker B motif; other site
490759007996	arginine finger; other site
490759007997	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
490759007998	DNA-binding interface [nucleotide binding]; DNA binding site
490759007999	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
490759008000	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
490759008001	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
490759008002	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
490759008003	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759008004	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
490759008005	substrate binding site [chemical binding]; other site
490759008006	oxyanion hole (OAH) forming residues; other site
490759008007	trimer interface [polypeptide binding]; other site
490759008008	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
490759008009	enoyl-CoA hydratase; Provisional; Region: PRK09076
490759008010	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759008011	substrate binding site [chemical binding]; other site
490759008012	oxyanion hole (OAH) forming residues; other site
490759008013	trimer interface [polypeptide binding]; other site
490759008014	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
490759008015	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759008016	active site
490759008017	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
490759008018	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
490759008019	tetrameric interface [polypeptide binding]; other site
490759008020	NAD binding site [chemical binding]; other site
490759008021	catalytic residues [active]
490759008022	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
490759008023	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
490759008024	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
490759008025	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
490759008026	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
490759008027	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
490759008028	hypothetical protein; Provisional; Region: PRK12378
490759008029	Methyltransferase domain; Region: Methyltransf_23; pfam13489
490759008030	Methyltransferase domain; Region: Methyltransf_12; pfam08242
490759008031	S-adenosylmethionine binding site [chemical binding]; other site
490759008032	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
490759008033	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
490759008034	RNA binding surface [nucleotide binding]; other site
490759008035	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
490759008036	probable active site [active]
490759008037	pteridine reductase; Provisional; Region: PRK09135
490759008038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759008039	NAD(P) binding site [chemical binding]; other site
490759008040	active site
490759008041	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
490759008042	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
490759008043	Cation efflux family; Region: Cation_efflux; cl00316
490759008044	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759008045	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759008046	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
490759008047	dimerization interface [polypeptide binding]; other site
490759008048	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
490759008049	CoenzymeA binding site [chemical binding]; other site
490759008050	subunit interaction site [polypeptide binding]; other site
490759008051	PHB binding site; other site
490759008052	Lysine efflux permease [General function prediction only]; Region: COG1279
490759008053	Protein of unknown function (DUF461); Region: DUF461; pfam04314
490759008054	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759008055	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759008056	metal binding site [ion binding]; metal-binding site
490759008057	active site
490759008058	I-site; other site
490759008059	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759008060	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
490759008061	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
490759008062	PhnA protein; Region: PhnA; pfam03831
490759008063	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
490759008064	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
490759008065	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
490759008066	short chain dehydrogenase; Provisional; Region: PRK07035
490759008067	classical (c) SDRs; Region: SDR_c; cd05233
490759008068	NAD(P) binding site [chemical binding]; other site
490759008069	active site
490759008070	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
490759008071	catalytic core [active]
490759008072	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
490759008073	Phosphotransferase enzyme family; Region: APH; pfam01636
490759008074	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
490759008075	putative active site [active]
490759008076	putative substrate binding site [chemical binding]; other site
490759008077	ATP binding site [chemical binding]; other site
490759008078	short chain dehydrogenase; Provisional; Region: PRK05650
490759008079	classical (c) SDRs; Region: SDR_c; cd05233
490759008080	NAD(P) binding site [chemical binding]; other site
490759008081	active site
490759008082	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
490759008083	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759008084	active site
490759008085	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759008086	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759008087	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
490759008088	substrate binding pocket [chemical binding]; other site
490759008089	dimerization interface [polypeptide binding]; other site
490759008090	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
490759008091	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
490759008092	tartrate dehydrogenase; Region: TTC; TIGR02089
490759008093	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
490759008094	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
490759008095	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
490759008096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759008097	homodimer interface [polypeptide binding]; other site
490759008098	catalytic residue [active]
490759008099	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
490759008100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759008101	active site
490759008102	phosphorylation site [posttranslational modification]
490759008103	intermolecular recognition site; other site
490759008104	dimerization interface [polypeptide binding]; other site
490759008105	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
490759008106	DNA binding residues [nucleotide binding]
490759008107	dimerization interface [polypeptide binding]; other site
490759008108	acetyl-CoA synthetase; Provisional; Region: PRK00174
490759008109	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
490759008110	active site
490759008111	CoA binding site [chemical binding]; other site
490759008112	acyl-activating enzyme (AAE) consensus motif; other site
490759008113	AMP binding site [chemical binding]; other site
490759008114	acetate binding site [chemical binding]; other site
490759008115	glutamate racemase; Provisional; Region: PRK00865
490759008116	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
490759008117	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
490759008118	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
490759008119	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
490759008120	putative NADH binding site [chemical binding]; other site
490759008121	putative active site [active]
490759008122	nudix motif; other site
490759008123	putative metal binding site [ion binding]; other site
490759008124	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
490759008125	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
490759008126	putative acyl-acceptor binding pocket; other site
490759008127	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
490759008128	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
490759008129	Glycoprotease family; Region: Peptidase_M22; pfam00814
490759008130	adenylate kinase; Reviewed; Region: adk; PRK00279
490759008131	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
490759008132	AMP-binding site [chemical binding]; other site
490759008133	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
490759008134	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
490759008135	putative deacylase active site [active]
490759008136	HDOD domain; Region: HDOD; pfam08668
490759008137	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
490759008138	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
490759008139	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
490759008140	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
490759008141	homodimer interface [polypeptide binding]; other site
490759008142	metal binding site [ion binding]; metal-binding site
490759008143	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
490759008144	homodimer interface [polypeptide binding]; other site
490759008145	active site
490759008146	putative chemical substrate binding site [chemical binding]; other site
490759008147	metal binding site [ion binding]; metal-binding site
490759008148	HD domain; Region: HD_4; pfam13328
490759008149	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
490759008150	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
490759008151	synthetase active site [active]
490759008152	NTP binding site [chemical binding]; other site
490759008153	metal binding site [ion binding]; metal-binding site
490759008154	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
490759008155	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
490759008156	TRAM domain; Region: TRAM; pfam01938
490759008157	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
490759008158	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759008159	S-adenosylmethionine binding site [chemical binding]; other site
490759008160	cysteine synthase B; Region: cysM; TIGR01138
490759008161	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
490759008162	dimer interface [polypeptide binding]; other site
490759008163	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759008164	catalytic residue [active]
490759008165	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
490759008166	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
490759008167	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759008168	dimer interface [polypeptide binding]; other site
490759008169	phosphorylation site [posttranslational modification]
490759008170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759008171	ATP binding site [chemical binding]; other site
490759008172	Mg2+ binding site [ion binding]; other site
490759008173	G-X-G motif; other site
490759008174	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759008175	active site
490759008176	phosphorylation site [posttranslational modification]
490759008177	intermolecular recognition site; other site
490759008178	dimerization interface [polypeptide binding]; other site
490759008179	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
490759008180	putative binding surface; other site
490759008181	active site
490759008182	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
490759008183	active site
490759008184	hydrophilic channel; other site
490759008185	dimerization interface [polypeptide binding]; other site
490759008186	catalytic residues [active]
490759008187	active site lid [active]
490759008188	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
490759008189	Recombination protein O N terminal; Region: RecO_N; pfam11967
490759008190	Recombination protein O C terminal; Region: RecO_C; pfam02565
490759008191	GTPase Era; Reviewed; Region: era; PRK00089
490759008192	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
490759008193	G1 box; other site
490759008194	GTP/Mg2+ binding site [chemical binding]; other site
490759008195	Switch I region; other site
490759008196	G2 box; other site
490759008197	Switch II region; other site
490759008198	G3 box; other site
490759008199	G4 box; other site
490759008200	G5 box; other site
490759008201	KH domain; Region: KH_2; pfam07650
490759008202	ribonuclease III; Reviewed; Region: rnc; PRK00102
490759008203	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
490759008204	dimerization interface [polypeptide binding]; other site
490759008205	active site
490759008206	metal binding site [ion binding]; metal-binding site
490759008207	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
490759008208	dsRNA binding site [nucleotide binding]; other site
490759008209	signal peptidase I; Provisional; Region: PRK10861
490759008210	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
490759008211	Catalytic site [active]
490759008212	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
490759008213	GTP-binding protein LepA; Provisional; Region: PRK05433
490759008214	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
490759008215	G1 box; other site
490759008216	putative GEF interaction site [polypeptide binding]; other site
490759008217	GTP/Mg2+ binding site [chemical binding]; other site
490759008218	Switch I region; other site
490759008219	G2 box; other site
490759008220	G3 box; other site
490759008221	Switch II region; other site
490759008222	G4 box; other site
490759008223	G5 box; other site
490759008224	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
490759008225	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
490759008226	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
490759008227	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
490759008228	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
490759008229	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
490759008230	protein binding site [polypeptide binding]; other site
490759008231	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
490759008232	protein binding site [polypeptide binding]; other site
490759008233	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
490759008234	anti-sigma E factor; Provisional; Region: rseB; PRK09455
490759008235	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
490759008236	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
490759008237	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
490759008238	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
490759008239	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
490759008240	DNA binding residues [nucleotide binding]
490759008241	L-aspartate oxidase; Provisional; Region: PRK09077
490759008242	L-aspartate oxidase; Provisional; Region: PRK06175
490759008243	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
490759008244	Uncharacterized conserved protein [Function unknown]; Region: COG2938
490759008245	putative global regulator; Reviewed; Region: PRK09559
490759008246	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
490759008247	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
490759008248	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
490759008249	ligand binding site [chemical binding]; other site
490759008250	active site
490759008251	UGI interface [polypeptide binding]; other site
490759008252	catalytic site [active]
490759008253	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
490759008254	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
490759008255	dimer interface [polypeptide binding]; other site
490759008256	putative anticodon binding site; other site
490759008257	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
490759008258	motif 1; other site
490759008259	active site
490759008260	motif 2; other site
490759008261	motif 3; other site
490759008262	peptide chain release factor 2; Validated; Region: prfB; PRK00578
490759008263	This domain is found in peptide chain release factors; Region: PCRF; smart00937
490759008264	RF-1 domain; Region: RF-1; pfam00472
490759008265	TPR repeat; Region: TPR_11; pfam13414
490759008266	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
490759008267	TPR motif; other site
490759008268	binding surface
490759008269	TPR repeat; Region: TPR_11; pfam13414
490759008270	exonuclease I; Provisional; Region: sbcB; PRK11779
490759008271	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
490759008272	active site
490759008273	catalytic site [active]
490759008274	substrate binding site [chemical binding]; other site
490759008275	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
490759008276	Response regulator receiver domain; Region: Response_reg; pfam00072
490759008277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759008278	active site
490759008279	phosphorylation site [posttranslational modification]
490759008280	intermolecular recognition site; other site
490759008281	dimerization interface [polypeptide binding]; other site
490759008282	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
490759008283	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
490759008284	PAS fold; Region: PAS_4; pfam08448
490759008285	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759008286	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759008287	metal binding site [ion binding]; metal-binding site
490759008288	active site
490759008289	I-site; other site
490759008290	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
490759008291	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
490759008292	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
490759008293	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
490759008294	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
490759008295	active site
490759008296	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
490759008297	dimer interface [polypeptide binding]; other site
490759008298	Predicted ATPase [General function prediction only]; Region: COG1485
490759008299	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
490759008300	Uncharacterized conserved protein [Function unknown]; Region: COG0327
490759008301	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
490759008302	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
490759008303	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
490759008304	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759008305	homodimer interface [polypeptide binding]; other site
490759008306	catalytic residue [active]
490759008307	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
490759008308	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
490759008309	NAD binding site [chemical binding]; other site
490759008310	dimerization interface [polypeptide binding]; other site
490759008311	product binding site; other site
490759008312	substrate binding site [chemical binding]; other site
490759008313	zinc binding site [ion binding]; other site
490759008314	catalytic residues [active]
490759008315	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
490759008316	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
490759008317	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
490759008318	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
490759008319	hinge; other site
490759008320	active site
490759008321	BolA-like protein; Region: BolA; cl00386
490759008322	STAS domain; Region: STAS_2; pfam13466
490759008323	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
490759008324	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
490759008325	mce related protein; Region: MCE; pfam02470
490759008326	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
490759008327	Permease; Region: Permease; cl00510
490759008328	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
490759008329	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
490759008330	Walker A/P-loop; other site
490759008331	ATP binding site [chemical binding]; other site
490759008332	Q-loop/lid; other site
490759008333	ABC transporter signature motif; other site
490759008334	Walker B; other site
490759008335	D-loop; other site
490759008336	H-loop/switch region; other site
490759008337	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
490759008338	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
490759008339	putative active site [active]
490759008340	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
490759008341	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
490759008342	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759008343	active site
490759008344	motif I; other site
490759008345	motif II; other site
490759008346	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
490759008347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
490759008348	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
490759008349	OstA-like protein; Region: OstA; pfam03968
490759008350	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
490759008351	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
490759008352	Walker A/P-loop; other site
490759008353	ATP binding site [chemical binding]; other site
490759008354	Q-loop/lid; other site
490759008355	ABC transporter signature motif; other site
490759008356	Walker B; other site
490759008357	D-loop; other site
490759008358	H-loop/switch region; other site
490759008359	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
490759008360	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
490759008361	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
490759008362	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
490759008363	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
490759008364	active site
490759008365	phosphorylation site [posttranslational modification]
490759008366	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
490759008367	AAA domain; Region: AAA_18; pfam13238
490759008368	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
490759008369	dimerization domain swap beta strand [polypeptide binding]; other site
490759008370	regulatory protein interface [polypeptide binding]; other site
490759008371	active site
490759008372	regulatory phosphorylation site [posttranslational modification]; other site
490759008373	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
490759008374	MgtE intracellular N domain; Region: MgtE_N; smart00924
490759008375	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
490759008376	Divalent cation transporter; Region: MgtE; cl00786
490759008377	Protein of unknown function (DUF615); Region: DUF615; pfam04751
490759008378	nitrilase; Region: PLN02798
490759008379	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
490759008380	putative active site [active]
490759008381	catalytic triad [active]
490759008382	dimer interface [polypeptide binding]; other site
490759008383	Protein of unknown function; Region: DUF3971; pfam13116
490759008384	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
490759008385	ribonuclease G; Provisional; Region: PRK11712
490759008386	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
490759008387	homodimer interface [polypeptide binding]; other site
490759008388	oligonucleotide binding site [chemical binding]; other site
490759008389	Maf-like protein; Region: Maf; pfam02545
490759008390	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
490759008391	active site
490759008392	dimer interface [polypeptide binding]; other site
490759008393	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
490759008394	rod shape-determining protein MreC; Provisional; Region: PRK13922
490759008395	rod shape-determining protein MreC; Region: MreC; pfam04085
490759008396	rod shape-determining protein MreB; Provisional; Region: PRK13927
490759008397	MreB and similar proteins; Region: MreB_like; cd10225
490759008398	nucleotide binding site [chemical binding]; other site
490759008399	Mg binding site [ion binding]; other site
490759008400	putative protofilament interaction site [polypeptide binding]; other site
490759008401	RodZ interaction site [polypeptide binding]; other site
490759008402	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
490759008403	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
490759008404	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
490759008405	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
490759008406	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
490759008407	GatB domain; Region: GatB_Yqey; smart00845
490759008408	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759008409	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759008410	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
490759008411	putative dimerization interface [polypeptide binding]; other site
490759008412	pyruvate carboxylase subunit A; Validated; Region: PRK07178
490759008413	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
490759008414	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
490759008415	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
490759008416	pyruvate carboxylase subunit B; Validated; Region: PRK09282
490759008417	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
490759008418	active site
490759008419	catalytic residues [active]
490759008420	metal binding site [ion binding]; metal-binding site
490759008421	homodimer binding site [polypeptide binding]; other site
490759008422	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
490759008423	carboxyltransferase (CT) interaction site; other site
490759008424	biotinylation site [posttranslational modification]; other site
490759008425	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
490759008426	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
490759008427	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
490759008428	FeS/SAM binding site; other site
490759008429	Nucleoid-associated protein [General function prediction only]; Region: COG3081
490759008430	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
490759008431	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
490759008432	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
490759008433	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
490759008434	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
490759008435	FeS/SAM binding site; other site
490759008436	TRAM domain; Region: TRAM; pfam01938
490759008437	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
490759008438	PhoH-like protein; Region: PhoH; pfam02562
490759008439	metal-binding heat shock protein; Provisional; Region: PRK00016
490759008440	FOG: CBS domain [General function prediction only]; Region: COG0517
490759008441	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
490759008442	Transporter associated domain; Region: CorC_HlyC; smart01091
490759008443	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
490759008444	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
490759008445	putative active site [active]
490759008446	catalytic triad [active]
490759008447	putative dimer interface [polypeptide binding]; other site
490759008448	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
490759008449	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
490759008450	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
490759008451	HIGH motif; other site
490759008452	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
490759008453	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
490759008454	active site
490759008455	KMSKS motif; other site
490759008456	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
490759008457	tRNA binding surface [nucleotide binding]; other site
490759008458	Lipopolysaccharide-assembly; Region: LptE; pfam04390
490759008459	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
490759008460	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
490759008461	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
490759008462	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
490759008463	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759008464	active site
490759008465	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
490759008466	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
490759008467	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
490759008468	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759008469	active site
490759008470	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
490759008471	SprA-related family; Region: SprA-related; pfam12118
490759008472	AAA domain; Region: AAA_26; pfam13500
490759008473	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
490759008474	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
490759008475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759008476	S-adenosylmethionine binding site [chemical binding]; other site
490759008477	RNA polymerase sigma factor; Provisional; Region: PRK12530
490759008478	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
490759008479	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
490759008480	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
490759008481	substrate-cofactor binding pocket; other site
490759008482	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759008483	catalytic residue [active]
490759008484	biotin synthase; Provisional; Region: PRK15108
490759008485	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
490759008486	FeS/SAM binding site; other site
490759008487	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
490759008488	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
490759008489	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
490759008490	active site
490759008491	Predicted dehydrogenase [General function prediction only]; Region: COG0579
490759008492	hydroxyglutarate oxidase; Provisional; Region: PRK11728
490759008493	serine/threonine protein kinase; Provisional; Region: PRK11768
490759008494	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
490759008495	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759008496	S-adenosylmethionine binding site [chemical binding]; other site
490759008497	Methyltransferase domain; Region: Methyltransf_31; pfam13847
490759008498	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759008499	S-adenosylmethionine binding site [chemical binding]; other site
490759008500	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
490759008501	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
490759008502	GDP-binding site [chemical binding]; other site
490759008503	ACT binding site; other site
490759008504	IMP binding site; other site
490759008505	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
490759008506	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
490759008507	dimer interface [polypeptide binding]; other site
490759008508	motif 1; other site
490759008509	active site
490759008510	motif 2; other site
490759008511	motif 3; other site
490759008512	HflC protein; Region: hflC; TIGR01932
490759008513	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
490759008514	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
490759008515	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
490759008516	HflK protein; Region: hflK; TIGR01933
490759008517	GTPase HflX; Provisional; Region: PRK11058
490759008518	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
490759008519	HflX GTPase family; Region: HflX; cd01878
490759008520	G1 box; other site
490759008521	GTP/Mg2+ binding site [chemical binding]; other site
490759008522	Switch I region; other site
490759008523	G2 box; other site
490759008524	G3 box; other site
490759008525	Switch II region; other site
490759008526	G4 box; other site
490759008527	G5 box; other site
490759008528	bacterial Hfq-like; Region: Hfq; cd01716
490759008529	hexamer interface [polypeptide binding]; other site
490759008530	Sm1 motif; other site
490759008531	RNA binding site [nucleotide binding]; other site
490759008532	Sm2 motif; other site
490759008533	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
490759008534	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
490759008535	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
490759008536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759008537	ATP binding site [chemical binding]; other site
490759008538	Mg2+ binding site [ion binding]; other site
490759008539	G-X-G motif; other site
490759008540	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
490759008541	ATP binding site [chemical binding]; other site
490759008542	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
490759008543	AMIN domain; Region: AMIN; pfam11741
490759008544	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
490759008545	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
490759008546	active site
490759008547	metal binding site [ion binding]; metal-binding site
490759008548	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
490759008549	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
490759008550	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
490759008551	Uncharacterized conserved protein [Function unknown]; Region: COG0062
490759008552	putative carbohydrate kinase; Provisional; Region: PRK10565
490759008553	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
490759008554	putative substrate binding site [chemical binding]; other site
490759008555	putative ATP binding site [chemical binding]; other site
490759008556	epoxyqueuosine reductase; Region: TIGR00276
490759008557	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
490759008558	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
490759008559	catalytic site [active]
490759008560	putative active site [active]
490759008561	putative substrate binding site [chemical binding]; other site
490759008562	dimer interface [polypeptide binding]; other site
490759008563	GTPase RsgA; Reviewed; Region: PRK12288
490759008564	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
490759008565	RNA binding site [nucleotide binding]; other site
490759008566	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
490759008567	GTPase/Zn-binding domain interface [polypeptide binding]; other site
490759008568	GTP/Mg2+ binding site [chemical binding]; other site
490759008569	G4 box; other site
490759008570	G5 box; other site
490759008571	G1 box; other site
490759008572	Switch I region; other site
490759008573	G2 box; other site
490759008574	G3 box; other site
490759008575	Switch II region; other site
490759008576	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
490759008577	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
490759008578	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
490759008579	motif 1; other site
490759008580	dimer interface [polypeptide binding]; other site
490759008581	active site
490759008582	motif 2; other site
490759008583	motif 3; other site
490759008584	elongation factor P; Validated; Region: PRK00529
490759008585	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
490759008586	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
490759008587	RNA binding site [nucleotide binding]; other site
490759008588	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
490759008589	RNA binding site [nucleotide binding]; other site
490759008590	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
490759008591	Radical SAM superfamily; Region: Radical_SAM; pfam04055
490759008592	FeS/SAM binding site; other site
490759008593	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
490759008594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
490759008595	active site
490759008596	phosphorylation site [posttranslational modification]
490759008597	dimerization interface [polypeptide binding]; other site
490759008598	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
490759008599	PAS fold; Region: PAS; pfam00989
490759008600	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759008601	metal binding site [ion binding]; metal-binding site
490759008602	active site
490759008603	I-site; other site
490759008604	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759008605	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
490759008606	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
490759008607	phosphoserine phosphatase SerB; Region: serB; TIGR00338
490759008608	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759008609	motif II; other site
490759008610	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
490759008611	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
490759008612	CAP-like domain; other site
490759008613	active site
490759008614	primary dimer interface [polypeptide binding]; other site
490759008615	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
490759008616	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759008617	dimer interface [polypeptide binding]; other site
490759008618	putative CheW interface [polypeptide binding]; other site
490759008619	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
490759008620	YceI-like domain; Region: YceI; cl01001
490759008621	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
490759008622	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
490759008623	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759008624	Mg2+ binding site [ion binding]; other site
490759008625	G-X-G motif; other site
490759008626	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
490759008627	anchoring element; other site
490759008628	dimer interface [polypeptide binding]; other site
490759008629	ATP binding site [chemical binding]; other site
490759008630	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
490759008631	active site
490759008632	metal binding site [ion binding]; metal-binding site
490759008633	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
490759008634	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
490759008635	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
490759008636	NAD(P) binding site [chemical binding]; other site
490759008637	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
490759008638	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
490759008639	active site
490759008640	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
490759008641	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
490759008642	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
490759008643	ABC1 family; Region: ABC1; cl17513
490759008644	NAD-dependent deacetylase; Provisional; Region: PRK00481
490759008645	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
490759008646	NAD+ binding site [chemical binding]; other site
490759008647	substrate binding site [chemical binding]; other site
490759008648	Zn binding site [ion binding]; other site
490759008649	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
490759008650	FAD binding domain; Region: FAD_binding_4; pfam01565
490759008651	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
490759008652	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
490759008653	ligand binding site [chemical binding]; other site
490759008654	NAD binding site [chemical binding]; other site
490759008655	tetramer interface [polypeptide binding]; other site
490759008656	catalytic site [active]
490759008657	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
490759008658	L-serine binding site [chemical binding]; other site
490759008659	ACT domain interface; other site
490759008660	beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753
490759008661	lycopene cyclase; Region: lycopene_cycl; TIGR01789
490759008662	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
490759008663	active site lid residues [active]
490759008664	substrate binding pocket [chemical binding]; other site
490759008665	catalytic residues [active]
490759008666	substrate-Mg2+ binding site; other site
490759008667	aspartate-rich region 1; other site
490759008668	aspartate-rich region 2; other site
490759008669	phytoene desaturase; Region: crtI_fam; TIGR02734
490759008670	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
490759008671	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
490759008672	substrate binding pocket [chemical binding]; other site
490759008673	substrate-Mg2+ binding site; other site
490759008674	aspartate-rich region 1; other site
490759008675	aspartate-rich region 2; other site
490759008676	MOSC domain; Region: MOSC; pfam03473
490759008677	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
490759008678	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
490759008679	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
490759008680	substrate binding site [chemical binding]; other site
490759008681	active site
490759008682	catalytic residues [active]
490759008683	heterodimer interface [polypeptide binding]; other site
490759008684	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
490759008685	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
490759008686	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759008687	catalytic residue [active]
490759008688	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759008689	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759008690	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759008691	dimerization interface [polypeptide binding]; other site
490759008692	putative outer membrane lipoprotein; Provisional; Region: PRK10510
490759008693	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
490759008694	ligand binding site [chemical binding]; other site
490759008695	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
490759008696	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
490759008697	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
490759008698	EamA-like transporter family; Region: EamA; pfam00892
490759008699	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
490759008700	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
490759008701	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
490759008702	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759008703	dimer interface [polypeptide binding]; other site
490759008704	putative CheW interface [polypeptide binding]; other site
490759008705	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
490759008706	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
490759008707	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759008708	active site
490759008709	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
490759008710	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
490759008711	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
490759008712	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
490759008713	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
490759008714	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
490759008715	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
490759008716	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
490759008717	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
490759008718	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
490759008719	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
490759008720	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
490759008721	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
490759008722	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
490759008723	dimer interface [polypeptide binding]; other site
490759008724	acyl-activating enzyme (AAE) consensus motif; other site
490759008725	putative active site [active]
490759008726	AMP binding site [chemical binding]; other site
490759008727	putative CoA binding site [chemical binding]; other site
490759008728	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
490759008729	translation initiation factor Sui1; Validated; Region: PRK06824
490759008730	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
490759008731	putative rRNA binding site [nucleotide binding]; other site
490759008732	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
490759008733	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
490759008734	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
490759008735	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
490759008736	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
490759008737	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759008738	dimerization interface [polypeptide binding]; other site
490759008739	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
490759008740	dimer interface [polypeptide binding]; other site
490759008741	phosphorylation site [posttranslational modification]
490759008742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759008743	ATP binding site [chemical binding]; other site
490759008744	Mg2+ binding site [ion binding]; other site
490759008745	G-X-G motif; other site
490759008746	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
490759008747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759008748	active site
490759008749	phosphorylation site [posttranslational modification]
490759008750	intermolecular recognition site; other site
490759008751	dimerization interface [polypeptide binding]; other site
490759008752	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
490759008753	DNA binding site [nucleotide binding]
490759008754	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
490759008755	Protein of unknown function, DUF482; Region: DUF482; pfam04339
490759008756	Dodecin; Region: Dodecin; pfam07311
490759008757	NAD-dependent deacetylase; Provisional; Region: PRK05333
490759008758	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
490759008759	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
490759008760	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
490759008761	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
490759008762	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759008763	Walker A/P-loop; other site
490759008764	ATP binding site [chemical binding]; other site
490759008765	Q-loop/lid; other site
490759008766	ABC transporter signature motif; other site
490759008767	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
490759008768	Walker B; other site
490759008769	ABC transporter; Region: ABC_tran_2; pfam12848
490759008770	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
490759008771	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
490759008772	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
490759008773	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
490759008774	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759008775	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759008776	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759008777	dimerization interface [polypeptide binding]; other site
490759008778	Predicted permeases [General function prediction only]; Region: RarD; COG2962
490759008779	EamA-like transporter family; Region: EamA; pfam00892
490759008780	Phosphate-starvation-inducible E; Region: PsiE; cl01264
490759008781	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
490759008782	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
490759008783	RNA binding surface [nucleotide binding]; other site
490759008784	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
490759008785	active site
490759008786	uracil binding [chemical binding]; other site
490759008787	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
490759008788	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
490759008789	N-acetyl-D-glucosamine binding site [chemical binding]; other site
490759008790	catalytic residue [active]
490759008791	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
490759008792	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
490759008793	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
490759008794	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
490759008795	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
490759008796	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759008797	putative active site [active]
490759008798	heme pocket [chemical binding]; other site
490759008799	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759008800	ATP binding site [chemical binding]; other site
490759008801	Mg2+ binding site [ion binding]; other site
490759008802	G-X-G motif; other site
490759008803	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
490759008804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759008805	active site
490759008806	phosphorylation site [posttranslational modification]
490759008807	intermolecular recognition site; other site
490759008808	dimerization interface [polypeptide binding]; other site
490759008809	BCCT family transporter; Region: BCCT; pfam02028
490759008810	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
490759008811	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
490759008812	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
490759008813	elongation factor P; Provisional; Region: PRK04542
490759008814	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
490759008815	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
490759008816	RNA binding site [nucleotide binding]; other site
490759008817	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
490759008818	RNA binding site [nucleotide binding]; other site
490759008819	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
490759008820	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
490759008821	ATP binding site [chemical binding]; other site
490759008822	C factor cell-cell signaling protein; Provisional; Region: PRK09009
490759008823	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
490759008824	NADP binding site [chemical binding]; other site
490759008825	homodimer interface [polypeptide binding]; other site
490759008826	active site
490759008827	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
490759008828	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
490759008829	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
490759008830	thioredoxin 2; Provisional; Region: PRK10996
490759008831	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
490759008832	catalytic residues [active]
490759008833	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
490759008834	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
490759008835	tetramer interface [polypeptide binding]; other site
490759008836	TPP-binding site [chemical binding]; other site
490759008837	heterodimer interface [polypeptide binding]; other site
490759008838	phosphorylation loop region [posttranslational modification]
490759008839	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
490759008840	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
490759008841	alpha subunit interface [polypeptide binding]; other site
490759008842	TPP binding site [chemical binding]; other site
490759008843	heterodimer interface [polypeptide binding]; other site
490759008844	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
490759008845	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
490759008846	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
490759008847	E3 interaction surface; other site
490759008848	lipoyl attachment site [posttranslational modification]; other site
490759008849	e3 binding domain; Region: E3_binding; pfam02817
490759008850	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
490759008851	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
490759008852	Catalytic domain of Protein Kinases; Region: PKc; cd00180
490759008853	active site
490759008854	ATP binding site [chemical binding]; other site
490759008855	substrate binding site [chemical binding]; other site
490759008856	activation loop (A-loop); other site
490759008857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759008858	S-adenosylmethionine binding site [chemical binding]; other site
490759008859	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
490759008860	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
490759008861	Protein of unknown function DUF72; Region: DUF72; cl00777
490759008862	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
490759008863	endonuclease III; Region: ENDO3c; smart00478
490759008864	minor groove reading motif; other site
490759008865	helix-hairpin-helix signature motif; other site
490759008866	substrate binding pocket [chemical binding]; other site
490759008867	active site
490759008868	endonuclease VIII; Provisional; Region: PRK10445
490759008869	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
490759008870	DNA binding site [nucleotide binding]
490759008871	catalytic residue [active]
490759008872	H2TH interface [polypeptide binding]; other site
490759008873	putative catalytic residues [active]
490759008874	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
490759008875	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
490759008876	NADH(P)-binding; Region: NAD_binding_10; pfam13460
490759008877	NAD(P) binding site [chemical binding]; other site
490759008878	putative active site [active]
490759008879	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
490759008880	EamA-like transporter family; Region: EamA; pfam00892
490759008881	EamA-like transporter family; Region: EamA; pfam00892
490759008882	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
490759008883	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
490759008884	dimer interface [polypeptide binding]; other site
490759008885	active site
490759008886	metal binding site [ion binding]; metal-binding site
490759008887	glutathione binding site [chemical binding]; other site
490759008888	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
490759008889	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
490759008890	active site residue [active]
490759008891	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
490759008892	Thioredoxin; Region: Thioredoxin_4; pfam13462
490759008893	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
490759008894	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
490759008895	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
490759008896	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
490759008897	HSP70 interaction site [polypeptide binding]; other site
490759008898	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
490759008899	substrate binding site [polypeptide binding]; other site
490759008900	Protein of unknown function (DUF2872); Region: DUF2872; pfam11071
490759008901	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
490759008902	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
490759008903	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
490759008904	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
490759008905	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
490759008906	SEC-C motif; Region: SEC-C; pfam02810
490759008907	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
490759008908	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
490759008909	putative NAD(P) binding site [chemical binding]; other site
490759008910	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
490759008911	CCGSCS motif protein; Region: CCGSCS; TIGR04101
490759008912	Major Facilitator Superfamily; Region: MFS_1; pfam07690
490759008913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759008914	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
490759008915	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
490759008916	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
490759008917	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
490759008918	putative NAD(P) binding site [chemical binding]; other site
490759008919	catalytic Zn binding site [ion binding]; other site
490759008920	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
490759008921	Prostaglandin dehydrogenases; Region: PGDH; cd05288
490759008922	NAD(P) binding site [chemical binding]; other site
490759008923	substrate binding site [chemical binding]; other site
490759008924	dimer interface [polypeptide binding]; other site
490759008925	myosin-cross-reactive antigen; Provisional; Region: PRK13977
490759008926	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
490759008927	putative cation:proton antiport protein; Provisional; Region: PRK10669
490759008928	TrkA-N domain; Region: TrkA_N; pfam02254
490759008929	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
490759008930	Fasciclin domain; Region: Fasciclin; pfam02469
490759008931	cytosine permease; Provisional; Region: codB; PRK11017
490759008932	Na binding site [ion binding]; other site
490759008933	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
490759008934	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
490759008935	cytosine deaminase; Provisional; Region: PRK09230
490759008936	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
490759008937	active site
490759008938	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
490759008939	Transglycosylase; Region: Transgly; cl17702
490759008940	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
490759008941	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
490759008942	catalytic residues [active]
490759008943	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
490759008944	Proline dehydrogenase; Region: Pro_dh; pfam01619
490759008945	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
490759008946	Glutamate binding site [chemical binding]; other site
490759008947	NAD binding site [chemical binding]; other site
490759008948	catalytic residues [active]
490759008949	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
490759008950	NAD(P) binding site [chemical binding]; other site
490759008951	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
490759008952	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
490759008953	putative DNA binding site [nucleotide binding]; other site
490759008954	putative Zn2+ binding site [ion binding]; other site
490759008955	AsnC family; Region: AsnC_trans_reg; pfam01037
490759008956	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
490759008957	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
490759008958	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
490759008959	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
490759008960	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509
490759008961	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659
490759008962	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
490759008963	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
490759008964	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
490759008965	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
490759008966	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
490759008967	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
490759008968	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759008969	Walker A/P-loop; other site
490759008970	ATP binding site [chemical binding]; other site
490759008971	Q-loop/lid; other site
490759008972	ABC transporter signature motif; other site
490759008973	Walker B; other site
490759008974	D-loop; other site
490759008975	H-loop/switch region; other site
490759008976	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
490759008977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759008978	dimer interface [polypeptide binding]; other site
490759008979	conserved gate region; other site
490759008980	putative PBP binding loops; other site
490759008981	ABC-ATPase subunit interface; other site
490759008982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759008983	dimer interface [polypeptide binding]; other site
490759008984	conserved gate region; other site
490759008985	putative PBP binding loops; other site
490759008986	ABC-ATPase subunit interface; other site
490759008987	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759008988	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759008989	substrate binding pocket [chemical binding]; other site
490759008990	membrane-bound complex binding site; other site
490759008991	hinge residues; other site
490759008992	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
490759008993	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
490759008994	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759008995	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
490759008996	substrate binding pocket [chemical binding]; other site
490759008997	dimerization interface [polypeptide binding]; other site
490759008998	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
490759008999	Ligand Binding Site [chemical binding]; other site
490759009000	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
490759009001	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
490759009002	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
490759009003	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
490759009004	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
490759009005	Domain of unknown function (DUF897); Region: DUF897; cl01312
490759009006	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
490759009007	Yqey-like protein; Region: YqeY; pfam09424
490759009008	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
490759009009	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
490759009010	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759009011	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759009012	metal binding site [ion binding]; metal-binding site
490759009013	active site
490759009014	I-site; other site
490759009015	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
490759009016	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
490759009017	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759009018	substrate binding pocket [chemical binding]; other site
490759009019	membrane-bound complex binding site; other site
490759009020	hinge residues; other site
490759009021	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
490759009022	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
490759009023	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
490759009024	enoyl-CoA hydratase; Provisional; Region: PRK07509
490759009025	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759009026	substrate binding site [chemical binding]; other site
490759009027	oxyanion hole (OAH) forming residues; other site
490759009028	trimer interface [polypeptide binding]; other site
490759009029	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
490759009030	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
490759009031	ATP binding site [chemical binding]; other site
490759009032	putative Mg++ binding site [ion binding]; other site
490759009033	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759009034	nucleotide binding region [chemical binding]; other site
490759009035	ATP-binding site [chemical binding]; other site
490759009036	Double zinc ribbon; Region: DZR; pfam12773
490759009037	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
490759009038	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
490759009039	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
490759009040	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
490759009041	NAD binding site [chemical binding]; other site
490759009042	catalytic Zn binding site [ion binding]; other site
490759009043	substrate binding site [chemical binding]; other site
490759009044	structural Zn binding site [ion binding]; other site
490759009045	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
490759009046	active site
490759009047	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
490759009048	classical (c) SDRs; Region: SDR_c; cd05233
490759009049	NAD(P) binding site [chemical binding]; other site
490759009050	active site
490759009051	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
490759009052	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
490759009053	cobalamin binding residues [chemical binding]; other site
490759009054	putative BtuC binding residues; other site
490759009055	dimer interface [polypeptide binding]; other site
490759009056	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
490759009057	dimerization interface [polypeptide binding]; other site
490759009058	putative DNA binding site [nucleotide binding]; other site
490759009059	putative Zn2+ binding site [ion binding]; other site
490759009060	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
490759009061	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
490759009062	putative NAD(P) binding site [chemical binding]; other site
490759009063	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
490759009064	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
490759009065	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
490759009066	Type II transport protein GspH; Region: GspH; pfam12019
490759009067	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
490759009068	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
490759009069	Walker A/P-loop; other site
490759009070	ATP binding site [chemical binding]; other site
490759009071	Q-loop/lid; other site
490759009072	ABC transporter signature motif; other site
490759009073	Walker B; other site
490759009074	D-loop; other site
490759009075	H-loop/switch region; other site
490759009076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009077	dimer interface [polypeptide binding]; other site
490759009078	conserved gate region; other site
490759009079	putative PBP binding loops; other site
490759009080	ABC-ATPase subunit interface; other site
490759009081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009082	dimer interface [polypeptide binding]; other site
490759009083	conserved gate region; other site
490759009084	putative PBP binding loops; other site
490759009085	ABC-ATPase subunit interface; other site
490759009086	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759009087	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759009088	substrate binding pocket [chemical binding]; other site
490759009089	membrane-bound complex binding site; other site
490759009090	hinge residues; other site
490759009091	Transcriptional regulators [Transcription]; Region: FadR; COG2186
490759009092	FCD domain; Region: FCD; pfam07729
490759009093	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
490759009094	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
490759009095	cytosine deaminase; Provisional; Region: PRK05985
490759009096	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
490759009097	active site
490759009098	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
490759009099	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
490759009100	TM-ABC transporter signature motif; other site
490759009101	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
490759009102	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
490759009103	Walker A/P-loop; other site
490759009104	ATP binding site [chemical binding]; other site
490759009105	Q-loop/lid; other site
490759009106	ABC transporter signature motif; other site
490759009107	Walker B; other site
490759009108	D-loop; other site
490759009109	H-loop/switch region; other site
490759009110	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
490759009111	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
490759009112	Walker A/P-loop; other site
490759009113	ATP binding site [chemical binding]; other site
490759009114	Q-loop/lid; other site
490759009115	ABC transporter signature motif; other site
490759009116	Walker B; other site
490759009117	D-loop; other site
490759009118	H-loop/switch region; other site
490759009119	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
490759009120	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
490759009121	TM-ABC transporter signature motif; other site
490759009122	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
490759009123	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
490759009124	putative ligand binding site [chemical binding]; other site
490759009125	SnoaL-like domain; Region: SnoaL_2; pfam12680
490759009126	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
490759009127	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
490759009128	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
490759009129	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759009130	short chain dehydrogenase; Provisional; Region: PRK07041
490759009131	NAD(P) binding site [chemical binding]; other site
490759009132	active site
490759009133	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759009134	active site
490759009135	Transcriptional regulators [Transcription]; Region: GntR; COG1802
490759009136	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759009137	DNA-binding site [nucleotide binding]; DNA binding site
490759009138	FCD domain; Region: FCD; pfam07729
490759009139	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759009140	putative CheW interface [polypeptide binding]; other site
490759009141	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
490759009142	ATP-grasp domain; Region: ATP-grasp_4; cl17255
490759009143	Nuclease-related domain; Region: NERD; pfam08378
490759009144	cyanate hydratase; Validated; Region: PRK02866
490759009145	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
490759009146	oligomer interface [polypeptide binding]; other site
490759009147	active site
490759009148	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
490759009149	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
490759009150	Walker A/P-loop; other site
490759009151	ATP binding site [chemical binding]; other site
490759009152	Q-loop/lid; other site
490759009153	ABC transporter signature motif; other site
490759009154	Walker B; other site
490759009155	D-loop; other site
490759009156	H-loop/switch region; other site
490759009157	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
490759009158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009159	dimer interface [polypeptide binding]; other site
490759009160	conserved gate region; other site
490759009161	putative PBP binding loops; other site
490759009162	ABC-ATPase subunit interface; other site
490759009163	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
490759009164	NMT1-like family; Region: NMT1_2; pfam13379
490759009165	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759009166	PAS domain; Region: PAS_9; pfam13426
490759009167	putative active site [active]
490759009168	heme pocket [chemical binding]; other site
490759009169	PAS fold; Region: PAS; pfam00989
490759009170	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759009171	putative active site [active]
490759009172	heme pocket [chemical binding]; other site
490759009173	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
490759009174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759009175	Walker A motif; other site
490759009176	ATP binding site [chemical binding]; other site
490759009177	Walker B motif; other site
490759009178	arginine finger; other site
490759009179	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
490759009180	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
490759009181	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
490759009182	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
490759009183	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
490759009184	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
490759009185	GAF domain; Region: GAF; pfam01590
490759009186	PAS domain S-box; Region: sensory_box; TIGR00229
490759009187	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759009188	putative active site [active]
490759009189	heme pocket [chemical binding]; other site
490759009190	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759009191	PAS domain; Region: PAS_9; pfam13426
490759009192	putative active site [active]
490759009193	heme pocket [chemical binding]; other site
490759009194	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759009195	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759009196	metal binding site [ion binding]; metal-binding site
490759009197	active site
490759009198	I-site; other site
490759009199	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759009200	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759009201	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
490759009202	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
490759009203	non-specific DNA binding site [nucleotide binding]; other site
490759009204	salt bridge; other site
490759009205	sequence-specific DNA binding site [nucleotide binding]; other site
490759009206	Transposase IS200 like; Region: Y1_Tnp; cl00848
490759009207	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
490759009208	classical (c) SDRs; Region: SDR_c; cd05233
490759009209	NAD(P) binding site [chemical binding]; other site
490759009210	active site
490759009211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759009212	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
490759009213	NAD(P) binding site [chemical binding]; other site
490759009214	active site
490759009215	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
490759009216	Integrase core domain; Region: rve_3; pfam13683
490759009217	PEP-CTERM family integral membrane protein; Region: PEP_integral; TIGR02921
490759009218	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
490759009219	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
490759009220	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
490759009221	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
490759009222	Walker A motif; other site
490759009223	ATP binding site [chemical binding]; other site
490759009224	Walker B motif; other site
490759009225	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
490759009226	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
490759009227	Short C-terminal domain; Region: SHOCT; pfam09851
490759009228	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759009229	ABC transporter signature motif; other site
490759009230	Walker B; other site
490759009231	D-loop; other site
490759009232	H-loop/switch region; other site
490759009233	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
490759009234	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
490759009235	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
490759009236	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
490759009237	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
490759009238	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
490759009239	UreF; Region: UreF; pfam01730
490759009240	urease accessory protein UreE; Provisional; Region: PRK14113
490759009241	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
490759009242	dimer interface [polypeptide binding]; other site
490759009243	catalytic residues [active]
490759009244	urease subunit alpha; Reviewed; Region: ureC; PRK13207
490759009245	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
490759009246	subunit interactions [polypeptide binding]; other site
490759009247	active site
490759009248	flap region; other site
490759009249	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
490759009250	gamma-beta subunit interface [polypeptide binding]; other site
490759009251	alpha-beta subunit interface [polypeptide binding]; other site
490759009252	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
490759009253	alpha-gamma subunit interface [polypeptide binding]; other site
490759009254	beta-gamma subunit interface [polypeptide binding]; other site
490759009255	UreD urease accessory protein; Region: UreD; pfam01774
490759009256	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
490759009257	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
490759009258	Walker A/P-loop; other site
490759009259	ATP binding site [chemical binding]; other site
490759009260	Q-loop/lid; other site
490759009261	ABC transporter signature motif; other site
490759009262	Walker B; other site
490759009263	D-loop; other site
490759009264	H-loop/switch region; other site
490759009265	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
490759009266	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
490759009267	Walker A/P-loop; other site
490759009268	ATP binding site [chemical binding]; other site
490759009269	Q-loop/lid; other site
490759009270	ABC transporter signature motif; other site
490759009271	Walker B; other site
490759009272	D-loop; other site
490759009273	H-loop/switch region; other site
490759009274	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
490759009275	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
490759009276	TM-ABC transporter signature motif; other site
490759009277	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
490759009278	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
490759009279	TM-ABC transporter signature motif; other site
490759009280	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
490759009281	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
490759009282	putative ligand binding site [chemical binding]; other site
490759009283	PAS fold; Region: PAS_4; pfam08448
490759009284	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759009285	putative active site [active]
490759009286	heme pocket [chemical binding]; other site
490759009287	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759009288	PAS domain; Region: PAS_9; pfam13426
490759009289	putative active site [active]
490759009290	heme pocket [chemical binding]; other site
490759009291	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759009292	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759009293	metal binding site [ion binding]; metal-binding site
490759009294	active site
490759009295	I-site; other site
490759009296	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
490759009297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009298	dimer interface [polypeptide binding]; other site
490759009299	conserved gate region; other site
490759009300	putative PBP binding loops; other site
490759009301	ABC-ATPase subunit interface; other site
490759009302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009303	dimer interface [polypeptide binding]; other site
490759009304	conserved gate region; other site
490759009305	putative PBP binding loops; other site
490759009306	ABC-ATPase subunit interface; other site
490759009307	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
490759009308	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759009309	Walker A/P-loop; other site
490759009310	ATP binding site [chemical binding]; other site
490759009311	Q-loop/lid; other site
490759009312	ABC transporter signature motif; other site
490759009313	Walker B; other site
490759009314	D-loop; other site
490759009315	H-loop/switch region; other site
490759009316	TOBE domain; Region: TOBE_2; pfam08402
490759009317	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
490759009318	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
490759009319	Predicted ATPase [General function prediction only]; Region: COG1485
490759009320	Predicted membrane protein [Function unknown]; Region: COG4541
490759009321	AzlC protein; Region: AzlC; pfam03591
490759009322	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
490759009323	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
490759009324	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
490759009325	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
490759009326	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
490759009327	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
490759009328	Predicted transcriptional regulators [Transcription]; Region: COG1733
490759009329	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
490759009330	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
490759009331	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
490759009332	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
490759009333	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
490759009334	ligand binding site [chemical binding]; other site
490759009335	homodimer interface [polypeptide binding]; other site
490759009336	NAD(P) binding site [chemical binding]; other site
490759009337	trimer interface B [polypeptide binding]; other site
490759009338	trimer interface A [polypeptide binding]; other site
490759009339	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
490759009340	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759009341	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
490759009342	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
490759009343	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759009344	dimer interface [polypeptide binding]; other site
490759009345	putative CheW interface [polypeptide binding]; other site
490759009346	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
490759009347	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
490759009348	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
490759009349	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
490759009350	NlpC/P60 family; Region: NLPC_P60; pfam00877
490759009351	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
490759009352	EamA-like transporter family; Region: EamA; pfam00892
490759009353	EamA-like transporter family; Region: EamA; pfam00892
490759009354	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
490759009355	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
490759009356	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
490759009357	NAD binding site [chemical binding]; other site
490759009358	Phe binding site; other site
490759009359	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
490759009360	Na2 binding site [ion binding]; other site
490759009361	putative substrate binding site 1 [chemical binding]; other site
490759009362	Na binding site 1 [ion binding]; other site
490759009363	putative substrate binding site 2 [chemical binding]; other site
490759009364	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
490759009365	Sel1-like repeats; Region: SEL1; smart00671
490759009366	choline dehydrogenase; Validated; Region: PRK02106
490759009367	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
490759009368	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
490759009369	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
490759009370	tetrameric interface [polypeptide binding]; other site
490759009371	NAD binding site [chemical binding]; other site
490759009372	catalytic residues [active]
490759009373	transcriptional regulator BetI; Validated; Region: PRK00767
490759009374	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
490759009375	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
490759009376	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
490759009377	Proline racemase; Region: Pro_racemase; pfam05544
490759009378	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
490759009379	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
490759009380	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
490759009381	NAD(P) binding site [chemical binding]; other site
490759009382	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
490759009383	PAS domain; Region: PAS_9; pfam13426
490759009384	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759009385	putative active site [active]
490759009386	heme pocket [chemical binding]; other site
490759009387	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
490759009388	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
490759009389	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
490759009390	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759009391	Walker A/P-loop; other site
490759009392	ATP binding site [chemical binding]; other site
490759009393	Q-loop/lid; other site
490759009394	ABC transporter signature motif; other site
490759009395	Walker B; other site
490759009396	D-loop; other site
490759009397	H-loop/switch region; other site
490759009398	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
490759009399	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
490759009400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009401	dimer interface [polypeptide binding]; other site
490759009402	conserved gate region; other site
490759009403	putative PBP binding loops; other site
490759009404	ABC-ATPase subunit interface; other site
490759009405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009406	dimer interface [polypeptide binding]; other site
490759009407	conserved gate region; other site
490759009408	putative PBP binding loops; other site
490759009409	ABC-ATPase subunit interface; other site
490759009410	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759009411	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759009412	metal binding site [ion binding]; metal-binding site
490759009413	active site
490759009414	I-site; other site
490759009415	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759009416	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
490759009417	Beta-lactamase; Region: Beta-lactamase; pfam00144
490759009418	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
490759009419	Mechanosensitive ion channel; Region: MS_channel; pfam00924
490759009420	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
490759009421	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
490759009422	NAD binding site [chemical binding]; other site
490759009423	catalytic residues [active]
490759009424	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
490759009425	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
490759009426	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
490759009427	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
490759009428	putative molybdopterin cofactor binding site [chemical binding]; other site
490759009429	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
490759009430	putative molybdopterin cofactor binding site; other site
490759009431	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
490759009432	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
490759009433	putative C-terminal domain interface [polypeptide binding]; other site
490759009434	putative GSH binding site (G-site) [chemical binding]; other site
490759009435	putative dimer interface [polypeptide binding]; other site
490759009436	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
490759009437	putative N-terminal domain interface [polypeptide binding]; other site
490759009438	putative dimer interface [polypeptide binding]; other site
490759009439	putative substrate binding pocket (H-site) [chemical binding]; other site
490759009440	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
490759009441	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
490759009442	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
490759009443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009444	dimer interface [polypeptide binding]; other site
490759009445	conserved gate region; other site
490759009446	putative PBP binding loops; other site
490759009447	ABC-ATPase subunit interface; other site
490759009448	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
490759009449	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759009450	Walker A/P-loop; other site
490759009451	ATP binding site [chemical binding]; other site
490759009452	Q-loop/lid; other site
490759009453	ABC transporter signature motif; other site
490759009454	Walker B; other site
490759009455	D-loop; other site
490759009456	H-loop/switch region; other site
490759009457	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
490759009458	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
490759009459	putative NAD(P) binding site [chemical binding]; other site
490759009460	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
490759009461	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
490759009462	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
490759009463	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
490759009464	metal binding site [ion binding]; metal-binding site
490759009465	Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378
490759009466	substrate binding pocket [chemical binding]; other site
490759009467	Isochorismatase family; Region: Isochorismatase; pfam00857
490759009468	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
490759009469	catalytic triad [active]
490759009470	conserved cis-peptide bond; other site
490759009471	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
490759009472	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
490759009473	putative acyl-acceptor binding pocket; other site
490759009474	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
490759009475	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
490759009476	intersubunit interface [polypeptide binding]; other site
490759009477	active site
490759009478	zinc binding site [ion binding]; other site
490759009479	Na+ binding site [ion binding]; other site
490759009480	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
490759009481	Phosphoglycerate kinase; Region: PGK; pfam00162
490759009482	substrate binding site [chemical binding]; other site
490759009483	hinge regions; other site
490759009484	ADP binding site [chemical binding]; other site
490759009485	catalytic site [active]
490759009486	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
490759009487	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
490759009488	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
490759009489	transketolase; Reviewed; Region: PRK12753
490759009490	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
490759009491	TPP-binding site [chemical binding]; other site
490759009492	dimer interface [polypeptide binding]; other site
490759009493	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
490759009494	PYR/PP interface [polypeptide binding]; other site
490759009495	dimer interface [polypeptide binding]; other site
490759009496	TPP binding site [chemical binding]; other site
490759009497	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
490759009498	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
490759009499	dimerization interface [polypeptide binding]; other site
490759009500	putative DNA binding site [nucleotide binding]; other site
490759009501	putative Zn2+ binding site [ion binding]; other site
490759009502	Methyltransferase domain; Region: Methyltransf_23; pfam13489
490759009503	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759009504	S-adenosylmethionine binding site [chemical binding]; other site
490759009505	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
490759009506	S-adenosylmethionine synthetase; Validated; Region: PRK05250
490759009507	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
490759009508	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
490759009509	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
490759009510	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
490759009511	homotetramer interface [polypeptide binding]; other site
490759009512	ligand binding site [chemical binding]; other site
490759009513	catalytic site [active]
490759009514	NAD binding site [chemical binding]; other site
490759009515	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
490759009516	FAD binding site [chemical binding]; other site
490759009517	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759009518	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759009519	substrate binding pocket [chemical binding]; other site
490759009520	membrane-bound complex binding site; other site
490759009521	hinge residues; other site
490759009522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009523	dimer interface [polypeptide binding]; other site
490759009524	conserved gate region; other site
490759009525	putative PBP binding loops; other site
490759009526	ABC-ATPase subunit interface; other site
490759009527	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
490759009528	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
490759009529	Walker A/P-loop; other site
490759009530	ATP binding site [chemical binding]; other site
490759009531	Q-loop/lid; other site
490759009532	ABC transporter signature motif; other site
490759009533	Walker B; other site
490759009534	D-loop; other site
490759009535	H-loop/switch region; other site
490759009536	PAAR motif; Region: PAAR_motif; pfam05488
490759009537	OsmC-like protein; Region: OsmC; pfam02566
490759009538	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
490759009539	TAP-like protein; Region: Abhydrolase_4; pfam08386
490759009540	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
490759009541	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
490759009542	DNA binding residues [nucleotide binding]
490759009543	dimerization interface [polypeptide binding]; other site
490759009544	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
490759009545	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
490759009546	inhibitor-cofactor binding pocket; inhibition site
490759009547	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759009548	catalytic residue [active]
490759009549	RNA methyltransferase, RsmE family; Region: TIGR00046
490759009550	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
490759009551	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
490759009552	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
490759009553	HDOD domain; Region: HDOD; pfam08668
490759009554	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
490759009555	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
490759009556	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
490759009557	putative dimer interface [polypeptide binding]; other site
490759009558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
490759009559	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
490759009560	PrkA family serine protein kinase; Provisional; Region: PRK15455
490759009561	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
490759009562	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
490759009563	hypothetical protein; Provisional; Region: PRK05325
490759009564	SpoVR family protein; Provisional; Region: PRK11767
490759009565	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
490759009566	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
490759009567	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
490759009568	Predicted transcriptional regulator [Transcription]; Region: COG1959
490759009569	Transcriptional regulator; Region: Rrf2; cl17282
490759009570	Protein of unknown function (DUF454); Region: DUF454; cl01063
490759009571	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
490759009572	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
490759009573	FeS/SAM binding site; other site
490759009574	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
490759009575	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
490759009576	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
490759009577	PYR/PP interface [polypeptide binding]; other site
490759009578	dimer interface [polypeptide binding]; other site
490759009579	TPP binding site [chemical binding]; other site
490759009580	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
490759009581	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
490759009582	TPP-binding site [chemical binding]; other site
490759009583	NosL; Region: NosL; pfam05573
490759009584	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
490759009585	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
490759009586	Walker A/P-loop; other site
490759009587	ATP binding site [chemical binding]; other site
490759009588	Q-loop/lid; other site
490759009589	ABC transporter signature motif; other site
490759009590	Walker B; other site
490759009591	D-loop; other site
490759009592	H-loop/switch region; other site
490759009593	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
490759009594	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
490759009595	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
490759009596	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
490759009597	nitrous-oxide reductase; Validated; Region: PRK02888
490759009598	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
490759009599	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
490759009600	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
490759009601	4Fe-4S binding domain; Region: Fer4_5; pfam12801
490759009602	4Fe-4S binding domain; Region: Fer4_5; pfam12801
490759009603	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
490759009604	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
490759009605	ligand binding site [chemical binding]; other site
490759009606	flexible hinge region; other site
490759009607	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
490759009608	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
490759009609	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
490759009610	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
490759009611	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
490759009612	4Fe-4S binding domain; Region: Fer4; cl02805
490759009613	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
490759009614	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
490759009615	[4Fe-4S] binding site [ion binding]; other site
490759009616	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
490759009617	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
490759009618	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
490759009619	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
490759009620	molybdopterin cofactor binding site; other site
490759009621	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759009622	putative substrate translocation pore; other site
490759009623	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
490759009624	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
490759009625	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759009626	dimerization interface [polypeptide binding]; other site
490759009627	GAF domain; Region: GAF_3; pfam13492
490759009628	Histidine kinase; Region: HisKA_3; pfam07730
490759009629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759009630	ATP binding site [chemical binding]; other site
490759009631	Mg2+ binding site [ion binding]; other site
490759009632	G-X-G motif; other site
490759009633	transcriptional regulator NarL; Provisional; Region: PRK10651
490759009634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759009635	active site
490759009636	phosphorylation site [posttranslational modification]
490759009637	intermolecular recognition site; other site
490759009638	dimerization interface [polypeptide binding]; other site
490759009639	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
490759009640	DNA binding residues [nucleotide binding]
490759009641	dimerization interface [polypeptide binding]; other site
490759009642	SCP-2 sterol transfer family; Region: SCP2; cl01225
490759009643	putative protease; Provisional; Region: PRK15447
490759009644	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
490759009645	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
490759009646	Peptidase family U32; Region: Peptidase_U32; pfam01136
490759009647	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
490759009648	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
490759009649	FeS/SAM binding site; other site
490759009650	HemN C-terminal domain; Region: HemN_C; pfam06969
490759009651	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
490759009652	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
490759009653	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
490759009654	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
490759009655	DNA binding residues [nucleotide binding]
490759009656	dimer interface [polypeptide binding]; other site
490759009657	putative metal binding site [ion binding]; other site
490759009658	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
490759009659	Cytochrome c; Region: Cytochrom_C; pfam00034
490759009660	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
490759009661	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
490759009662	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
490759009663	Putative water exit pathway; other site
490759009664	Putative proton exit pathway; other site
490759009665	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
490759009666	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
490759009667	metal ion-dependent adhesion site (MIDAS); other site
490759009668	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
490759009669	Subunit I/III interface [polypeptide binding]; other site
490759009670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759009671	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
490759009672	Walker A motif; other site
490759009673	ATP binding site [chemical binding]; other site
490759009674	Walker B motif; other site
490759009675	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
490759009676	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
490759009677	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
490759009678	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
490759009679	Cu(I) binding site [ion binding]; other site
490759009680	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
490759009681	Ligand Binding Site [chemical binding]; other site
490759009682	BCCT family transporter; Region: BCCT; pfam02028
490759009683	Membrane transport protein; Region: Mem_trans; cl09117
490759009684	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
490759009685	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
490759009686	ligand binding site [chemical binding]; other site
490759009687	flexible hinge region; other site
490759009688	glycerate dehydrogenase; Provisional; Region: PRK06487
490759009689	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
490759009690	putative ligand binding site [chemical binding]; other site
490759009691	putative NAD binding site [chemical binding]; other site
490759009692	catalytic site [active]
490759009693	NnrS protein; Region: NnrS; pfam05940
490759009694	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
490759009695	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
490759009696	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
490759009697	FMN binding site [chemical binding]; other site
490759009698	substrate binding site [chemical binding]; other site
490759009699	putative catalytic residue [active]
490759009700	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759009701	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
490759009702	active site
490759009703	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
490759009704	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
490759009705	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
490759009706	dimer interface [polypeptide binding]; other site
490759009707	active site
490759009708	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759009709	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
490759009710	substrate binding site [chemical binding]; other site
490759009711	oxyanion hole (OAH) forming residues; other site
490759009712	trimer interface [polypeptide binding]; other site
490759009713	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
490759009714	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
490759009715	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
490759009716	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
490759009717	Transcriptional regulator [Transcription]; Region: IclR; COG1414
490759009718	Bacterial transcriptional regulator; Region: IclR; pfam01614
490759009719	acetyl-CoA acetyltransferase; Provisional; Region: PRK08131
490759009720	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
490759009721	dimer interface [polypeptide binding]; other site
490759009722	active site
490759009723	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
490759009724	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
490759009725	FAD binding site [chemical binding]; other site
490759009726	substrate binding pocket [chemical binding]; other site
490759009727	catalytic base [active]
490759009728	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
490759009729	DctM-like transporters; Region: DctM; pfam06808
490759009730	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
490759009731	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
490759009732	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
490759009733	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759009734	active site
490759009735	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
490759009736	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
490759009737	active site
490759009738	aldolase II superfamily protein; Provisional; Region: PRK07044
490759009739	intersubunit interface [polypeptide binding]; other site
490759009740	active site
490759009741	Zn2+ binding site [ion binding]; other site
490759009742	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
490759009743	active site 1 [active]
490759009744	active site 2 [active]
490759009745	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
490759009746	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
490759009747	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
490759009748	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
490759009749	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
490759009750	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
490759009751	acyl-activating enzyme (AAE) consensus motif; other site
490759009752	putative AMP binding site [chemical binding]; other site
490759009753	putative active site [active]
490759009754	putative CoA binding site [chemical binding]; other site
490759009755	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
490759009756	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
490759009757	Phosphotransferase enzyme family; Region: APH; pfam01636
490759009758	putative active site [active]
490759009759	putative substrate binding site [chemical binding]; other site
490759009760	ATP binding site [chemical binding]; other site
490759009761	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
490759009762	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759009763	NAD(P) binding site [chemical binding]; other site
490759009764	active site
490759009765	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
490759009766	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
490759009767	FAD binding site [chemical binding]; other site
490759009768	substrate binding site [chemical binding]; other site
490759009769	catalytic base [active]
490759009770	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
490759009771	CoenzymeA binding site [chemical binding]; other site
490759009772	subunit interaction site [polypeptide binding]; other site
490759009773	PHB binding site; other site
490759009774	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
490759009775	classical (c) SDRs; Region: SDR_c; cd05233
490759009776	NAD(P) binding site [chemical binding]; other site
490759009777	active site
490759009778	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
490759009779	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
490759009780	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
490759009781	acyl-activating enzyme (AAE) consensus motif; other site
490759009782	putative AMP binding site [chemical binding]; other site
490759009783	putative active site [active]
490759009784	putative CoA binding site [chemical binding]; other site
490759009785	enoyl-CoA hydratase; Provisional; Region: PRK06688
490759009786	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759009787	substrate binding site [chemical binding]; other site
490759009788	oxyanion hole (OAH) forming residues; other site
490759009789	trimer interface [polypeptide binding]; other site
490759009790	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759009791	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
490759009792	DctM-like transporters; Region: DctM; pfam06808
490759009793	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
490759009794	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
490759009795	putative FMN binding site [chemical binding]; other site
490759009796	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
490759009797	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
490759009798	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
490759009799	active site
490759009800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759009801	putative substrate translocation pore; other site
490759009802	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759009803	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
490759009804	Ligand Binding Site [chemical binding]; other site
490759009805	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
490759009806	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
490759009807	NnrS protein; Region: NnrS; pfam05940
490759009808	3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174
490759009809	active site 2 [active]
490759009810	active site 1 [active]
490759009811	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
490759009812	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
490759009813	dimer interface [polypeptide binding]; other site
490759009814	active site
490759009815	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
490759009816	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
490759009817	putative protease; Provisional; Region: PRK15452
490759009818	Peptidase family U32; Region: Peptidase_U32; pfam01136
490759009819	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
490759009820	putative ABC transporter; Region: ycf24; CHL00085
490759009821	FeS assembly ATPase SufC; Region: sufC; TIGR01978
490759009822	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
490759009823	Walker A/P-loop; other site
490759009824	ATP binding site [chemical binding]; other site
490759009825	Q-loop/lid; other site
490759009826	ABC transporter signature motif; other site
490759009827	Walker B; other site
490759009828	D-loop; other site
490759009829	H-loop/switch region; other site
490759009830	FeS assembly protein SufD; Region: sufD; TIGR01981
490759009831	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
490759009832	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
490759009833	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
490759009834	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
490759009835	catalytic residue [active]
490759009836	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
490759009837	probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406
490759009838	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
490759009839	LPP20 lipoprotein; Region: LPP20; pfam02169
490759009840	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
490759009841	active site
490759009842	NTP binding site [chemical binding]; other site
490759009843	metal binding triad [ion binding]; metal-binding site
490759009844	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
490759009845	putative acyltransferase; Provisional; Region: PRK05790
490759009846	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
490759009847	dimer interface [polypeptide binding]; other site
490759009848	active site
490759009849	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
490759009850	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
490759009851	SecA binding site; other site
490759009852	Preprotein binding site; other site
490759009853	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
490759009854	active site residue [active]
490759009855	phosphoglyceromutase; Provisional; Region: PRK05434
490759009856	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
490759009857	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
490759009858	Peptidase family M23; Region: Peptidase_M23; pfam01551
490759009859	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
490759009860	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
490759009861	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
490759009862	protein binding site [polypeptide binding]; other site
490759009863	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
490759009864	Catalytic dyad [active]
490759009865	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
490759009866	NodB motif; other site
490759009867	putative active site [active]
490759009868	putative catalytic site [active]
490759009869	Zn binding site [ion binding]; other site
490759009870	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
490759009871	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
490759009872	substrate binding site [chemical binding]; other site
490759009873	glutamase interaction surface [polypeptide binding]; other site
490759009874	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
490759009875	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
490759009876	catalytic residues [active]
490759009877	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
490759009878	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
490759009879	putative active site [active]
490759009880	oxyanion strand; other site
490759009881	catalytic triad [active]
490759009882	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
490759009883	putative active site pocket [active]
490759009884	4-fold oligomerization interface [polypeptide binding]; other site
490759009885	metal binding residues [ion binding]; metal-binding site
490759009886	3-fold/trimer interface [polypeptide binding]; other site
490759009887	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
490759009888	putative hydrophobic ligand binding site [chemical binding]; other site
490759009889	AsmA family; Region: AsmA; pfam05170
490759009890	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
490759009891	adenine DNA glycosylase; Provisional; Region: PRK10880
490759009892	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
490759009893	minor groove reading motif; other site
490759009894	helix-hairpin-helix signature motif; other site
490759009895	substrate binding pocket [chemical binding]; other site
490759009896	active site
490759009897	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
490759009898	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
490759009899	DNA binding and oxoG recognition site [nucleotide binding]
490759009900	Bacterial Fe(2+) trafficking; Region: Iron_traffic; pfam04362
490759009901	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759009902	S-adenosylmethionine binding site [chemical binding]; other site
490759009903	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
490759009904	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
490759009905	Homeodomain-like domain; Region: HTH_32; pfam13565
490759009906	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
490759009907	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
490759009908	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
490759009909	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
490759009910	urea carboxylase; Region: urea_carbox; TIGR02712
490759009911	ATP-grasp domain; Region: ATP-grasp_4; cl17255
490759009912	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
490759009913	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
490759009914	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
490759009915	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
490759009916	carboxyltransferase (CT) interaction site; other site
490759009917	biotinylation site [posttranslational modification]; other site
490759009918	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
490759009919	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
490759009920	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
490759009921	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
490759009922	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
490759009923	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
490759009924	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
490759009925	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
490759009926	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
490759009927	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
490759009928	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009929	dimer interface [polypeptide binding]; other site
490759009930	conserved gate region; other site
490759009931	putative PBP binding loops; other site
490759009932	ABC-ATPase subunit interface; other site
490759009933	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
490759009934	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
490759009935	Walker A/P-loop; other site
490759009936	ATP binding site [chemical binding]; other site
490759009937	Q-loop/lid; other site
490759009938	ABC transporter signature motif; other site
490759009939	Walker B; other site
490759009940	D-loop; other site
490759009941	H-loop/switch region; other site
490759009942	allophanate hydrolase; Provisional; Region: PRK08186
490759009943	Amidase; Region: Amidase; pfam01425
490759009944	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
490759009945	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
490759009946	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
490759009947	Walker A/P-loop; other site
490759009948	ATP binding site [chemical binding]; other site
490759009949	Q-loop/lid; other site
490759009950	ABC transporter signature motif; other site
490759009951	Walker B; other site
490759009952	D-loop; other site
490759009953	H-loop/switch region; other site
490759009954	NMT1/THI5 like; Region: NMT1; pfam09084
490759009955	substrate binding pocket [chemical binding]; other site
490759009956	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
490759009957	membrane-bound complex binding site; other site
490759009958	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
490759009959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009960	dimer interface [polypeptide binding]; other site
490759009961	conserved gate region; other site
490759009962	putative PBP binding loops; other site
490759009963	ABC-ATPase subunit interface; other site
490759009964	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
490759009965	Fatty acid desaturase; Region: FA_desaturase; pfam00487
490759009966	putative di-iron ligands [ion binding]; other site
490759009967	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
490759009968	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
490759009969	putative transposase OrfB; Reviewed; Region: PHA02517
490759009970	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
490759009971	Amidase; Region: Amidase; cl11426
490759009972	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
490759009973	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759009974	substrate binding pocket [chemical binding]; other site
490759009975	membrane-bound complex binding site; other site
490759009976	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
490759009977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759009978	dimer interface [polypeptide binding]; other site
490759009979	conserved gate region; other site
490759009980	putative PBP binding loops; other site
490759009981	ABC-ATPase subunit interface; other site
490759009982	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
490759009983	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
490759009984	metal binding site [ion binding]; metal-binding site
490759009985	dimer interface [polypeptide binding]; other site
490759009986	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
490759009987	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
490759009988	Walker A/P-loop; other site
490759009989	ATP binding site [chemical binding]; other site
490759009990	Q-loop/lid; other site
490759009991	ABC transporter signature motif; other site
490759009992	Walker B; other site
490759009993	D-loop; other site
490759009994	H-loop/switch region; other site
490759009995	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
490759009996	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759009997	DNA-binding site [nucleotide binding]; DNA binding site
490759009998	UTRA domain; Region: UTRA; pfam07702
490759009999	serine/threonine transporter SstT; Provisional; Region: PRK13628
490759010000	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
490759010001	shikimate kinase; Reviewed; Region: aroK; PRK00131
490759010002	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
490759010003	ADP binding site [chemical binding]; other site
490759010004	magnesium binding site [ion binding]; other site
490759010005	putative shikimate binding site; other site
490759010006	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
490759010007	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
490759010008	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759010009	dimerization interface [polypeptide binding]; other site
490759010010	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759010011	dimer interface [polypeptide binding]; other site
490759010012	putative CheW interface [polypeptide binding]; other site
490759010013	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759010014	PAS domain; Region: PAS_9; pfam13426
490759010015	putative active site [active]
490759010016	heme pocket [chemical binding]; other site
490759010017	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
490759010018	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
490759010019	Chromate transporter; Region: Chromate_transp; pfam02417
490759010020	DNA photolyase; Region: DNA_photolyase; pfam00875
490759010021	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
490759010022	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
490759010023	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
490759010024	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
490759010025	active site
490759010026	Protein of unknown function (DUF465); Region: DUF465; cl01070
490759010027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759010028	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
490759010029	putative substrate translocation pore; other site
490759010030	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
490759010031	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
490759010032	Walker A/P-loop; other site
490759010033	ATP binding site [chemical binding]; other site
490759010034	Q-loop/lid; other site
490759010035	ABC transporter signature motif; other site
490759010036	Walker B; other site
490759010037	D-loop; other site
490759010038	H-loop/switch region; other site
490759010039	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
490759010040	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759010041	substrate binding pocket [chemical binding]; other site
490759010042	membrane-bound complex binding site; other site
490759010043	hinge residues; other site
490759010044	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
490759010045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759010046	dimer interface [polypeptide binding]; other site
490759010047	conserved gate region; other site
490759010048	putative PBP binding loops; other site
490759010049	ABC-ATPase subunit interface; other site
490759010050	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
490759010051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759010052	dimer interface [polypeptide binding]; other site
490759010053	conserved gate region; other site
490759010054	putative PBP binding loops; other site
490759010055	ABC-ATPase subunit interface; other site
490759010056	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
490759010057	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
490759010058	putative active site [active]
490759010059	Zn binding site [ion binding]; other site
490759010060	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
490759010061	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
490759010062	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
490759010063	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
490759010064	carboxyltransferase (CT) interaction site; other site
490759010065	biotinylation site [posttranslational modification]; other site
490759010066	succinylarginine dihydrolase; Provisional; Region: PRK13281
490759010067	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
490759010068	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
490759010069	NAD(P) binding site [chemical binding]; other site
490759010070	catalytic residues [active]
490759010071	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
490759010072	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
490759010073	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
490759010074	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
490759010075	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
490759010076	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
490759010077	inhibitor-cofactor binding pocket; inhibition site
490759010078	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759010079	catalytic residue [active]
490759010080	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
490759010081	active site
490759010082	catalytic site [active]
490759010083	substrate binding site [chemical binding]; other site
490759010084	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
490759010085	GIY-YIG motif/motif A; other site
490759010086	active site
490759010087	catalytic site [active]
490759010088	putative DNA binding site [nucleotide binding]; other site
490759010089	metal binding site [ion binding]; metal-binding site
490759010090	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
490759010091	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
490759010092	putative trimer interface [polypeptide binding]; other site
490759010093	putative metal binding site [ion binding]; other site
490759010094	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
490759010095	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759010096	substrate binding site [chemical binding]; other site
490759010097	oxyanion hole (OAH) forming residues; other site
490759010098	trimer interface [polypeptide binding]; other site
490759010099	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
490759010100	enoyl-CoA hydratase; Provisional; Region: PRK08140
490759010101	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
490759010102	substrate binding site [chemical binding]; other site
490759010103	oxyanion hole (OAH) forming residues; other site
490759010104	trimer interface [polypeptide binding]; other site
490759010105	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
490759010106	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
490759010107	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
490759010108	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
490759010109	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
490759010110	CoenzymeA binding site [chemical binding]; other site
490759010111	subunit interaction site [polypeptide binding]; other site
490759010112	PHB binding site; other site
490759010113	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
490759010114	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
490759010115	dimer interface [polypeptide binding]; other site
490759010116	active site
490759010117	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
490759010118	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
490759010119	acyl-activating enzyme (AAE) consensus motif; other site
490759010120	AMP binding site [chemical binding]; other site
490759010121	active site
490759010122	CoA binding site [chemical binding]; other site
490759010123	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
490759010124	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
490759010125	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
490759010126	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
490759010127	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
490759010128	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
490759010129	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
490759010130	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
490759010131	FAD binding pocket [chemical binding]; other site
490759010132	FAD binding motif [chemical binding]; other site
490759010133	phosphate binding motif [ion binding]; other site
490759010134	beta-alpha-beta structure motif; other site
490759010135	NAD(p) ribose binding residues [chemical binding]; other site
490759010136	NAD binding pocket [chemical binding]; other site
490759010137	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
490759010138	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
490759010139	catalytic loop [active]
490759010140	iron binding site [ion binding]; other site
490759010141	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
490759010142	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
490759010143	substrate binding site [chemical binding]; other site
490759010144	dimer interface [polypeptide binding]; other site
490759010145	NADP binding site [chemical binding]; other site
490759010146	catalytic residues [active]
490759010147	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
490759010148	substrate binding site [chemical binding]; other site
490759010149	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
490759010150	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
490759010151	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
490759010152	DctM-like transporters; Region: DctM; pfam06808
490759010153	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
490759010154	Hemerythrin-like domain; Region: Hr-like; cd12108
490759010155	Fe binding site [ion binding]; other site
490759010156	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
490759010157	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
490759010158	Walker A/P-loop; other site
490759010159	ATP binding site [chemical binding]; other site
490759010160	Q-loop/lid; other site
490759010161	ABC transporter signature motif; other site
490759010162	Walker B; other site
490759010163	D-loop; other site
490759010164	H-loop/switch region; other site
490759010165	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
490759010166	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
490759010167	Walker A/P-loop; other site
490759010168	ATP binding site [chemical binding]; other site
490759010169	Q-loop/lid; other site
490759010170	ABC transporter signature motif; other site
490759010171	Walker B; other site
490759010172	D-loop; other site
490759010173	H-loop/switch region; other site
490759010174	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
490759010175	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
490759010176	TM-ABC transporter signature motif; other site
490759010177	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
490759010178	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
490759010179	TM-ABC transporter signature motif; other site
490759010180	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
490759010181	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
490759010182	putative ligand binding site [chemical binding]; other site
490759010183	PaaX-like protein; Region: PaaX; pfam07848
490759010184	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
490759010185	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
490759010186	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
490759010187	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
490759010188	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
490759010189	E3 interaction surface; other site
490759010190	lipoyl attachment site [posttranslational modification]; other site
490759010191	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
490759010192	E3 interaction surface; other site
490759010193	lipoyl attachment site [posttranslational modification]; other site
490759010194	e3 binding domain; Region: E3_binding; pfam02817
490759010195	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
490759010196	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
490759010197	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
490759010198	dimer interface [polypeptide binding]; other site
490759010199	TPP-binding site [chemical binding]; other site
490759010200	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
490759010201	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
490759010202	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
490759010203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759010204	Walker A motif; other site
490759010205	ATP binding site [chemical binding]; other site
490759010206	Walker B motif; other site
490759010207	arginine finger; other site
490759010208	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
490759010209	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
490759010210	MarR family; Region: MarR; pfam01047
490759010211	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
490759010212	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
490759010213	dimerization interface [polypeptide binding]; other site
490759010214	ligand binding site [chemical binding]; other site
490759010215	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
490759010216	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
490759010217	TM-ABC transporter signature motif; other site
490759010218	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
490759010219	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
490759010220	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
490759010221	TM-ABC transporter signature motif; other site
490759010222	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
490759010223	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
490759010224	Walker A/P-loop; other site
490759010225	ATP binding site [chemical binding]; other site
490759010226	Q-loop/lid; other site
490759010227	ABC transporter signature motif; other site
490759010228	Walker B; other site
490759010229	D-loop; other site
490759010230	H-loop/switch region; other site
490759010231	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
490759010232	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
490759010233	Walker A/P-loop; other site
490759010234	ATP binding site [chemical binding]; other site
490759010235	Q-loop/lid; other site
490759010236	ABC transporter signature motif; other site
490759010237	Walker B; other site
490759010238	D-loop; other site
490759010239	H-loop/switch region; other site
490759010240	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
490759010241	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
490759010242	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
490759010243	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
490759010244	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
490759010245	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
490759010246	RNase E interface [polypeptide binding]; other site
490759010247	trimer interface [polypeptide binding]; other site
490759010248	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
490759010249	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
490759010250	RNase E interface [polypeptide binding]; other site
490759010251	trimer interface [polypeptide binding]; other site
490759010252	active site
490759010253	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
490759010254	putative nucleic acid binding region [nucleotide binding]; other site
490759010255	G-X-X-G motif; other site
490759010256	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
490759010257	RNA binding site [nucleotide binding]; other site
490759010258	domain interface; other site
490759010259	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
490759010260	16S/18S rRNA binding site [nucleotide binding]; other site
490759010261	S13e-L30e interaction site [polypeptide binding]; other site
490759010262	25S rRNA binding site [nucleotide binding]; other site
490759010263	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
490759010264	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
490759010265	RNA binding site [nucleotide binding]; other site
490759010266	active site
490759010267	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
490759010268	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
490759010269	translation initiation factor IF-2; Region: IF-2; TIGR00487
490759010270	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
490759010271	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
490759010272	G1 box; other site
490759010273	putative GEF interaction site [polypeptide binding]; other site
490759010274	GTP/Mg2+ binding site [chemical binding]; other site
490759010275	Switch I region; other site
490759010276	G2 box; other site
490759010277	G3 box; other site
490759010278	Switch II region; other site
490759010279	G4 box; other site
490759010280	G5 box; other site
490759010281	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
490759010282	Translation-initiation factor 2; Region: IF-2; pfam11987
490759010283	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
490759010284	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
490759010285	NusA N-terminal domain; Region: NusA_N; pfam08529
490759010286	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
490759010287	RNA binding site [nucleotide binding]; other site
490759010288	homodimer interface [polypeptide binding]; other site
490759010289	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
490759010290	G-X-X-G motif; other site
490759010291	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
490759010292	G-X-X-G motif; other site
490759010293	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
490759010294	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
490759010295	ribosome maturation protein RimP; Reviewed; Region: PRK00092
490759010296	Sm and related proteins; Region: Sm_like; cl00259
490759010297	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
490759010298	putative oligomer interface [polypeptide binding]; other site
490759010299	putative RNA binding site [nucleotide binding]; other site
490759010300	Preprotein translocase SecG subunit; Region: SecG; pfam03840
490759010301	triosephosphate isomerase; Provisional; Region: PRK14567
490759010302	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
490759010303	substrate binding site [chemical binding]; other site
490759010304	dimer interface [polypeptide binding]; other site
490759010305	catalytic triad [active]
490759010306	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
490759010307	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
490759010308	active site
490759010309	substrate binding site [chemical binding]; other site
490759010310	metal binding site [ion binding]; metal-binding site
490759010311	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
490759010312	dihydropteroate synthase; Region: DHPS; TIGR01496
490759010313	substrate binding pocket [chemical binding]; other site
490759010314	dimer interface [polypeptide binding]; other site
490759010315	inhibitor binding site; inhibition site
490759010316	FtsH Extracellular; Region: FtsH_ext; pfam06480
490759010317	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
490759010318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759010319	Walker A motif; other site
490759010320	ATP binding site [chemical binding]; other site
490759010321	Walker B motif; other site
490759010322	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
490759010323	NAD binding site [chemical binding]; other site
490759010324	arginine finger; other site
490759010325	Peptidase family M41; Region: Peptidase_M41; pfam01434
490759010326	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
490759010327	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
490759010328	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
490759010329	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
490759010330	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
490759010331	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
490759010332	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
490759010333	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
490759010334	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
490759010335	ATP-grasp domain; Region: ATP-grasp_4; cl17255
490759010336	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
490759010337	IMP binding site; other site
490759010338	dimer interface [polypeptide binding]; other site
490759010339	interdomain contacts; other site
490759010340	partial ornithine binding site; other site
490759010341	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
490759010342	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
490759010343	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
490759010344	catalytic site [active]
490759010345	subunit interface [polypeptide binding]; other site
490759010346	dihydrodipicolinate reductase; Provisional; Region: PRK00048
490759010347	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
490759010348	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
490759010349	chaperone protein DnaJ; Provisional; Region: PRK10767
490759010350	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
490759010351	HSP70 interaction site [polypeptide binding]; other site
490759010352	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
490759010353	substrate binding site [polypeptide binding]; other site
490759010354	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
490759010355	Zn binding sites [ion binding]; other site
490759010356	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
490759010357	dimer interface [polypeptide binding]; other site
490759010358	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
490759010359	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
490759010360	nucleotide binding site [chemical binding]; other site
490759010361	GrpE; Region: GrpE; pfam01025
490759010362	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
490759010363	dimer interface [polypeptide binding]; other site
490759010364	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
490759010365	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
490759010366	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
490759010367	Walker A/P-loop; other site
490759010368	ATP binding site [chemical binding]; other site
490759010369	Q-loop/lid; other site
490759010370	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
490759010371	ABC transporter signature motif; other site
490759010372	Walker B; other site
490759010373	D-loop; other site
490759010374	H-loop/switch region; other site
490759010375	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
490759010376	metal binding site 2 [ion binding]; metal-binding site
490759010377	putative DNA binding helix; other site
490759010378	metal binding site 1 [ion binding]; metal-binding site
490759010379	dimer interface [polypeptide binding]; other site
490759010380	structural Zn2+ binding site [ion binding]; other site
490759010381	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
490759010382	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
490759010383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
490759010384	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
490759010385	putative coenzyme Q binding site [chemical binding]; other site
490759010386	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
490759010387	Na2 binding site [ion binding]; other site
490759010388	putative substrate binding site 1 [chemical binding]; other site
490759010389	Na binding site 1 [ion binding]; other site
490759010390	putative substrate binding site 2 [chemical binding]; other site
490759010391	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
490759010392	SmpB-tmRNA interface; other site
490759010393	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
490759010394	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
490759010395	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
490759010396	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759010397	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759010398	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
490759010399	dimerization interface [polypeptide binding]; other site
490759010400	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
490759010401	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759010402	DctM-like transporters; Region: DctM; pfam06808
490759010403	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
490759010404	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
490759010405	Domain of unknown function (DUF932); Region: DUF932; pfam06067
490759010406	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
490759010407	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
490759010408	putative active site [active]
490759010409	putative NTP binding site [chemical binding]; other site
490759010410	putative nucleic acid binding site [nucleotide binding]; other site
490759010411	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
490759010412	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
490759010413	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
490759010414	Transcriptional regulators [Transcription]; Region: MarR; COG1846
490759010415	MarR family; Region: MarR_2; pfam12802
490759010416	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
490759010417	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
490759010418	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
490759010419	FMN-binding pocket [chemical binding]; other site
490759010420	flavin binding motif; other site
490759010421	phosphate binding motif [ion binding]; other site
490759010422	beta-alpha-beta structure motif; other site
490759010423	NAD binding pocket [chemical binding]; other site
490759010424	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
490759010425	catalytic loop [active]
490759010426	iron binding site [ion binding]; other site
490759010427	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
490759010428	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
490759010429	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759010430	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759010431	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
490759010432	putative effector binding pocket; other site
490759010433	putative dimerization interface [polypeptide binding]; other site
490759010434	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759010435	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759010436	LysR substrate binding domain; Region: LysR_substrate; pfam03466
490759010437	dimerization interface [polypeptide binding]; other site
490759010438	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
490759010439	2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291
490759010440	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
490759010441	NADP binding site [chemical binding]; other site
490759010442	dimer interface [polypeptide binding]; other site
490759010443	Integrase core domain; Region: rve_3; pfam13683
490759010444	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759010445	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759010446	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
490759010447	putative effector binding pocket; other site
490759010448	dimerization interface [polypeptide binding]; other site
490759010449	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
490759010450	glutathionine S-transferase; Provisional; Region: PRK10542
490759010451	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
490759010452	N-terminal domain interface [polypeptide binding]; other site
490759010453	dimer interface [polypeptide binding]; other site
490759010454	substrate binding pocket (H-site) [chemical binding]; other site
490759010455	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
490759010456	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
490759010457	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
490759010458	active site 1 [active]
490759010459	dimer interface [polypeptide binding]; other site
490759010460	hexamer interface [polypeptide binding]; other site
490759010461	active site 2 [active]
490759010462	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
490759010463	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
490759010464	WHG domain; Region: WHG; pfam13305
490759010465	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
490759010466	agmatinase; Region: agmatinase; TIGR01230
490759010467	oligomer interface [polypeptide binding]; other site
490759010468	putative active site [active]
490759010469	Mn binding site [ion binding]; other site
490759010470	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
490759010471	Nucleoside recognition; Region: Gate; pfam07670
490759010472	hypothetical protein; Provisional; Region: PRK07524
490759010473	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
490759010474	PYR/PP interface [polypeptide binding]; other site
490759010475	dimer interface [polypeptide binding]; other site
490759010476	TPP binding site [chemical binding]; other site
490759010477	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
490759010478	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
490759010479	TPP-binding site [chemical binding]; other site
490759010480	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
490759010481	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
490759010482	Na binding site [ion binding]; other site
490759010483	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
490759010484	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
490759010485	Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110
490759010486	NAD(P) binding site [chemical binding]; other site
490759010487	catalytic residues [active]
490759010488	catalytic residues [active]
490759010489	UTRA domain; Region: UTRA; cl17743
490759010490	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
490759010491	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
490759010492	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
490759010493	active site
490759010494	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
490759010495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759010496	ABC-ATPase subunit interface; other site
490759010497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759010498	dimer interface [polypeptide binding]; other site
490759010499	conserved gate region; other site
490759010500	putative PBP binding loops; other site
490759010501	ABC-ATPase subunit interface; other site
490759010502	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
490759010503	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759010504	Walker A/P-loop; other site
490759010505	ATP binding site [chemical binding]; other site
490759010506	Q-loop/lid; other site
490759010507	ABC transporter signature motif; other site
490759010508	Walker B; other site
490759010509	D-loop; other site
490759010510	H-loop/switch region; other site
490759010511	TOBE domain; Region: TOBE_2; pfam08402
490759010512	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
490759010513	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
490759010514	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
490759010515	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
490759010516	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759010517	motif II; other site
490759010518	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
490759010519	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
490759010520	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
490759010521	catalytic residue [active]
490759010522	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
490759010523	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
490759010524	putative metal binding site [ion binding]; other site
490759010525	Helix-turn-helix domain; Region: HTH_17; pfam12728
490759010526	PBP superfamily domain; Region: PBP_like; pfam12727
490759010527	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759010528	dimer interface [polypeptide binding]; other site
490759010529	conserved gate region; other site
490759010530	putative PBP binding loops; other site
490759010531	ABC-ATPase subunit interface; other site
490759010532	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
490759010533	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759010534	Q-loop/lid; other site
490759010535	ABC transporter signature motif; other site
490759010536	Walker B; other site
490759010537	D-loop; other site
490759010538	H-loop/switch region; other site
490759010539	PBP superfamily domain; Region: PBP_like_2; pfam12849
490759010540	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
490759010541	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
490759010542	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
490759010543	GTP binding site; other site
490759010544	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
490759010545	Walker A motif; other site
490759010546	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK14690
490759010547	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
490759010548	dimer interface [polypeptide binding]; other site
490759010549	putative functional site; other site
490759010550	putative MPT binding site; other site
490759010551	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
490759010552	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
490759010553	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
490759010554	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
490759010555	Ferredoxin [Energy production and conversion]; Region: COG1146
490759010556	4Fe-4S binding domain; Region: Fer4; pfam00037
490759010557	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
490759010558	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
490759010559	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
490759010560	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
490759010561	[4Fe-4S] binding site [ion binding]; other site
490759010562	molybdopterin cofactor binding site; other site
490759010563	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
490759010564	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
490759010565	molybdopterin cofactor binding site; other site
490759010566	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
490759010567	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
490759010568	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
490759010569	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
490759010570	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
490759010571	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
490759010572	putative metal binding site [ion binding]; other site
490759010573	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
490759010574	CoA-transferase family III; Region: CoA_transf_3; pfam02515
490759010575	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
490759010576	CoA-transferase family III; Region: CoA_transf_3; pfam02515
490759010577	BCCT family transporter; Region: BCCT; cl00569
490759010578	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
490759010579	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
490759010580	putative active site [active]
490759010581	metal binding site [ion binding]; metal-binding site
490759010582	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
490759010583	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
490759010584	tetrameric interface [polypeptide binding]; other site
490759010585	NAD binding site [chemical binding]; other site
490759010586	catalytic residues [active]
490759010587	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
490759010588	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759010589	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
490759010590	dimerization interface [polypeptide binding]; other site
490759010591	substrate binding pocket [chemical binding]; other site
490759010592	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
490759010593	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
490759010594	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
490759010595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759010596	active site
490759010597	phosphorylation site [posttranslational modification]
490759010598	intermolecular recognition site; other site
490759010599	dimerization interface [polypeptide binding]; other site
490759010600	malate:quinone oxidoreductase; Validated; Region: PRK05257
490759010601	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
490759010602	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
490759010603	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
490759010604	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
490759010605	methionine sulfoxide reductase B; Provisional; Region: PRK00222
490759010606	SelR domain; Region: SelR; pfam01641
490759010607	methionine sulfoxide reductase A; Provisional; Region: PRK14054
490759010608	fumarate hydratase; Reviewed; Region: fumC; PRK00485
490759010609	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
490759010610	tetramer interface [polypeptide binding]; other site
490759010611	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
490759010612	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
490759010613	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
490759010614	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650
490759010615	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
490759010616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759010617	S-adenosylmethionine binding site [chemical binding]; other site
490759010618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
490759010619	SCP-2 sterol transfer family; Region: SCP2; pfam02036
490759010620	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
490759010621	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
490759010622	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
490759010623	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
490759010624	metal binding site [ion binding]; metal-binding site
490759010625	twin arginine translocase protein A; Provisional; Region: tatA; PRK04598
490759010626	sec-independent translocase; Provisional; Region: tatB; PRK00404
490759010627	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
490759010628	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
490759010629	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
490759010630	Protein of unknown function (DUF808); Region: DUF808; pfam05661
490759010631	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714
490759010632	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
490759010633	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
490759010634	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
490759010635	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
490759010636	proline aminopeptidase P II; Provisional; Region: PRK10879
490759010637	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
490759010638	active site
490759010639	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
490759010640	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
490759010641	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
490759010642	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
490759010643	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
490759010644	Walker A/P-loop; other site
490759010645	ATP binding site [chemical binding]; other site
490759010646	Q-loop/lid; other site
490759010647	ABC transporter signature motif; other site
490759010648	Walker B; other site
490759010649	D-loop; other site
490759010650	H-loop/switch region; other site
490759010651	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
490759010652	TIGR02449 family protein; Region: TIGR02449
490759010653	Cell division protein ZapA; Region: ZapA; pfam05164
490759010654	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
490759010655	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
490759010656	threonine dehydratase; Reviewed; Region: PRK09224
490759010657	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
490759010658	tetramer interface [polypeptide binding]; other site
490759010659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759010660	catalytic residue [active]
490759010661	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
490759010662	putative Ile/Val binding site [chemical binding]; other site
490759010663	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
490759010664	putative Ile/Val binding site [chemical binding]; other site
490759010665	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
490759010666	tetramer (dimer of dimers) interface [polypeptide binding]; other site
490759010667	active site
490759010668	dimer interface [polypeptide binding]; other site
490759010669	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
490759010670	dimer interface [polypeptide binding]; other site
490759010671	substrate binding site [chemical binding]; other site
490759010672	metal binding sites [ion binding]; metal-binding site
490759010673	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
490759010674	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759010675	dimerization interface [polypeptide binding]; other site
490759010676	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759010677	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759010678	metal binding site [ion binding]; metal-binding site
490759010679	active site
490759010680	I-site; other site
490759010681	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759010682	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
490759010683	Dehydroquinase class II; Region: DHquinase_II; pfam01220
490759010684	active site
490759010685	trimer interface [polypeptide binding]; other site
490759010686	dimer interface [polypeptide binding]; other site
490759010687	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
490759010688	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
490759010689	carboxyltransferase (CT) interaction site; other site
490759010690	biotinylation site [posttranslational modification]; other site
490759010691	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
490759010692	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
490759010693	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
490759010694	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
490759010695	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
490759010696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
490759010697	thioredoxin 2; Provisional; Region: PRK10996
490759010698	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
490759010699	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
490759010700	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
490759010701	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
490759010702	FMN binding site [chemical binding]; other site
490759010703	active site
490759010704	catalytic residues [active]
490759010705	substrate binding site [chemical binding]; other site
490759010706	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
490759010707	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
490759010708	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
490759010709	purine monophosphate binding site [chemical binding]; other site
490759010710	dimer interface [polypeptide binding]; other site
490759010711	putative catalytic residues [active]
490759010712	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
490759010713	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
490759010714	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
490759010715	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
490759010716	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
490759010717	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
490759010718	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
490759010719	putative cation:proton antiport protein; Provisional; Region: PRK10669
490759010720	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
490759010721	TrkA-N domain; Region: TrkA_N; pfam02254
490759010722	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
490759010723	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759010724	Walker A motif; other site
490759010725	ATP binding site [chemical binding]; other site
490759010726	Walker B motif; other site
490759010727	arginine finger; other site
490759010728	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
490759010729	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
490759010730	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
490759010731	putative active site [active]
490759010732	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
490759010733	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
490759010734	transmembrane helices; other site
490759010735	TrkA-C domain; Region: TrkA_C; pfam02080
490759010736	TrkA-C domain; Region: TrkA_C; pfam02080
490759010737	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
490759010738	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
490759010739	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
490759010740	tetramer interface [polypeptide binding]; other site
490759010741	active site
490759010742	Mg2+/Mn2+ binding site [ion binding]; other site
490759010743	isocitrate lyase; Region: PLN02892
490759010744	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
490759010745	putative transporter; Provisional; Region: PRK11660
490759010746	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
490759010747	Sulfate transporter family; Region: Sulfate_transp; pfam00916
490759010748	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
490759010749	Protein of unknown function, DUF399; Region: DUF399; pfam04187
490759010750	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
490759010751	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
490759010752	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759010753	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
490759010754	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
490759010755	DctM-like transporters; Region: DctM; pfam06808
490759010756	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
490759010757	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
490759010758	dimerization interface [polypeptide binding]; other site
490759010759	DPS ferroxidase diiron center [ion binding]; other site
490759010760	ion pore; other site
490759010761	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
490759010762	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
490759010763	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759010764	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
490759010765	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
490759010766	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
490759010767	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
490759010768	HSP70 interaction site [polypeptide binding]; other site
490759010769	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
490759010770	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
490759010771	HlyD family secretion protein; Region: HlyD_3; pfam13437
490759010772	multidrug efflux protein; Reviewed; Region: PRK09579
490759010773	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
490759010774	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
490759010775	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
490759010776	active site
490759010777	dimerization interface [polypeptide binding]; other site
490759010778	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
490759010779	thiS-thiF/thiG interaction site; other site
490759010780	Protein of unknown function (DUF423); Region: DUF423; pfam04241
490759010781	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
490759010782	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
490759010783	active site
490759010784	metal binding site [ion binding]; metal-binding site
490759010785	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
490759010786	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
490759010787	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
490759010788	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
490759010789	SurA N-terminal domain; Region: SurA_N; pfam09312
490759010790	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
490759010791	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
490759010792	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
490759010793	Organic solvent tolerance protein; Region: OstA_C; pfam04453
490759010794	Phosphotransferase enzyme family; Region: APH; pfam01636
490759010795	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
490759010796	substrate binding site [chemical binding]; other site
490759010797	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
490759010798	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
490759010799	Substrate binding site; other site
490759010800	metal-binding site
490759010801	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
490759010802	putative metal binding site [ion binding]; other site
490759010803	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
490759010804	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
490759010805	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
490759010806	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
490759010807	substrate binding site [chemical binding]; other site
490759010808	hexamer interface [polypeptide binding]; other site
490759010809	metal binding site [ion binding]; metal-binding site
490759010810	phosphoglycolate phosphatase; Provisional; Region: PRK13222
490759010811	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759010812	motif II; other site
490759010813	anthranilate synthase component I; Provisional; Region: PRK13565
490759010814	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
490759010815	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
490759010816	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
490759010817	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
490759010818	glutamine binding [chemical binding]; other site
490759010819	catalytic triad [active]
490759010820	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
490759010821	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
490759010822	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
490759010823	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
490759010824	active site
490759010825	ribulose/triose binding site [chemical binding]; other site
490759010826	phosphate binding site [ion binding]; other site
490759010827	substrate (anthranilate) binding pocket [chemical binding]; other site
490759010828	product (indole) binding pocket [chemical binding]; other site
490759010829	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759010830	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759010831	metal binding site [ion binding]; metal-binding site
490759010832	active site
490759010833	I-site; other site
490759010834	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
490759010835	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
490759010836	putative C-terminal domain interface [polypeptide binding]; other site
490759010837	putative GSH binding site (G-site) [chemical binding]; other site
490759010838	putative dimer interface [polypeptide binding]; other site
490759010839	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
490759010840	N-terminal domain interface [polypeptide binding]; other site
490759010841	dimer interface [polypeptide binding]; other site
490759010842	substrate binding pocket (H-site) [chemical binding]; other site
490759010843	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
490759010844	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
490759010845	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
490759010846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759010847	dimer interface [polypeptide binding]; other site
490759010848	conserved gate region; other site
490759010849	putative PBP binding loops; other site
490759010850	ABC-ATPase subunit interface; other site
490759010851	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759010852	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
490759010853	Walker A/P-loop; other site
490759010854	ATP binding site [chemical binding]; other site
490759010855	Q-loop/lid; other site
490759010856	ABC transporter signature motif; other site
490759010857	Walker B; other site
490759010858	D-loop; other site
490759010859	H-loop/switch region; other site
490759010860	TOBE domain; Region: TOBE; pfam03459
490759010861	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
490759010862	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
490759010863	ligand binding site [chemical binding]; other site
490759010864	flexible hinge region; other site
490759010865	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
490759010866	putative switch regulator; other site
490759010867	non-specific DNA interactions [nucleotide binding]; other site
490759010868	DNA binding site [nucleotide binding]
490759010869	sequence specific DNA binding site [nucleotide binding]; other site
490759010870	putative cAMP binding site [chemical binding]; other site
490759010871	OsmC-like protein; Region: OsmC; cl00767
490759010872	phosphoribulokinase; Provisional; Region: PRK15453
490759010873	active site
490759010874	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
490759010875	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759010876	metal binding site [ion binding]; metal-binding site
490759010877	active site
490759010878	I-site; other site
490759010879	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759010880	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
490759010881	N-acetylglutamate synthase; Validated; Region: PRK05279
490759010882	putative feedback inhibition sensing region; other site
490759010883	putative nucleotide binding site [chemical binding]; other site
490759010884	putative substrate binding site [chemical binding]; other site
490759010885	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
490759010886	Coenzyme A binding pocket [chemical binding]; other site
490759010887	acetylornithine deacetylase; Provisional; Region: PRK05111
490759010888	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
490759010889	metal binding site [ion binding]; metal-binding site
490759010890	putative dimer interface [polypeptide binding]; other site
490759010891	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
490759010892	feedback inhibition sensing region; other site
490759010893	homohexameric interface [polypeptide binding]; other site
490759010894	nucleotide binding site [chemical binding]; other site
490759010895	N-acetyl-L-glutamate binding site [chemical binding]; other site
490759010896	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
490759010897	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
490759010898	active site
490759010899	substrate binding site [chemical binding]; other site
490759010900	metal binding site [ion binding]; metal-binding site
490759010901	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
490759010902	trimer interface [polypeptide binding]; other site
490759010903	active site
490759010904	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
490759010905	Flavoprotein; Region: Flavoprotein; pfam02441
490759010906	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
490759010907	S-formylglutathione hydrolase; Region: PLN02442
490759010908	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
490759010909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759010910	phosphorylation site [posttranslational modification]
490759010911	DNA repair protein radc; Region: radc; TIGR00608
490759010912	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
490759010913	MPN+ (JAMM) motif; other site
490759010914	Zinc-binding site [ion binding]; other site
490759010915	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
490759010916	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
490759010917	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
490759010918	putative catalytic site [active]
490759010919	putative metal binding site [ion binding]; other site
490759010920	putative phosphate binding site [ion binding]; other site
490759010921	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
490759010922	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
490759010923	catalytic residues [active]
490759010924	hinge region; other site
490759010925	alpha helical domain; other site
490759010926	Cytochrome c553 [Energy production and conversion]; Region: COG2863
490759010927	Cytochrome c; Region: Cytochrom_C; cl11414
490759010928	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
490759010929	G1 box; other site
490759010930	GTP/Mg2+ binding site [chemical binding]; other site
490759010931	Switch I region; other site
490759010932	G2 box; other site
490759010933	G3 box; other site
490759010934	Switch II region; other site
490759010935	G4 box; other site
490759010936	G5 box; other site
490759010937	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
490759010938	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
490759010939	Bacterial transcriptional repressor; Region: TetR; pfam13972
490759010940	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
490759010941	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
490759010942	NAD(P) binding site [chemical binding]; other site
490759010943	catalytic residues [active]
490759010944	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
490759010945	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
490759010946	active site
490759010947	(T/H)XGH motif; other site
490759010948	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
490759010949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
490759010950	polyphosphate kinase; Provisional; Region: PRK05443
490759010951	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
490759010952	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
490759010953	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
490759010954	putative active site [active]
490759010955	catalytic site [active]
490759010956	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
490759010957	putative domain interface [polypeptide binding]; other site
490759010958	putative active site [active]
490759010959	catalytic site [active]
490759010960	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
490759010961	dimer interface [polypeptide binding]; other site
490759010962	allosteric magnesium binding site [ion binding]; other site
490759010963	active site
490759010964	aspartate-rich active site metal binding site; other site
490759010965	Schiff base residues; other site
490759010966	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
490759010967	Protein of unknown function (DUF503); Region: DUF503; pfam04456
490759010968	putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799
490759010969	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
490759010970	catalytic residue [active]
490759010971	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
490759010972	Phosphate transporter family; Region: PHO4; pfam01384
490759010973	Phosphate transporter family; Region: PHO4; cl00396
490759010974	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
490759010975	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
490759010976	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
490759010977	active site
490759010978	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
490759010979	catalytic triad [active]
490759010980	dimer interface [polypeptide binding]; other site
490759010981	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
490759010982	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759010983	Rubredoxin [Energy production and conversion]; Region: COG1773
490759010984	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
490759010985	iron binding site [ion binding]; other site
490759010986	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
490759010987	active site
490759010988	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
490759010989	Chorismate lyase; Region: Chor_lyase; cl01230
490759010990	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
490759010991	UbiA prenyltransferase family; Region: UbiA; pfam01040
490759010992	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
490759010993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759010994	active site
490759010995	phosphorylation site [posttranslational modification]
490759010996	intermolecular recognition site; other site
490759010997	dimerization interface [polypeptide binding]; other site
490759010998	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
490759010999	DNA binding site [nucleotide binding]
490759011000	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
490759011001	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
490759011002	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759011003	dimer interface [polypeptide binding]; other site
490759011004	phosphorylation site [posttranslational modification]
490759011005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759011006	ATP binding site [chemical binding]; other site
490759011007	Mg2+ binding site [ion binding]; other site
490759011008	G-X-G motif; other site
490759011009	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
490759011010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759011011	active site
490759011012	phosphorylation site [posttranslational modification]
490759011013	intermolecular recognition site; other site
490759011014	dimerization interface [polypeptide binding]; other site
490759011015	Transglycosylase SLT domain; Region: SLT_2; pfam13406
490759011016	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
490759011017	N-acetyl-D-glucosamine binding site [chemical binding]; other site
490759011018	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
490759011019	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
490759011020	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
490759011021	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
490759011022	RNA binding surface [nucleotide binding]; other site
490759011023	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
490759011024	active site
490759011025	uracil binding [chemical binding]; other site
490759011026	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
490759011027	XFP N-terminal domain; Region: XFP_N; pfam09364
490759011028	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
490759011029	DNA-binding site [nucleotide binding]; DNA binding site
490759011030	RNA-binding motif; other site
490759011031	chromosome condensation membrane protein; Provisional; Region: PRK14196
490759011032	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
490759011033	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759011034	active site
490759011035	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
490759011036	ATP-dependent helicase HepA; Validated; Region: PRK04914
490759011037	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
490759011038	ATP binding site [chemical binding]; other site
490759011039	putative Mg++ binding site [ion binding]; other site
490759011040	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759011041	nucleotide binding region [chemical binding]; other site
490759011042	ATP-binding site [chemical binding]; other site
490759011043	putative sulfate transport protein CysZ; Validated; Region: PRK04949
490759011044	VanZ like family; Region: VanZ; pfam04892
490759011045	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
490759011046	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
490759011047	active site residue [active]
490759011048	mechanosensitive channel MscS; Provisional; Region: PRK10334
490759011049	Conserved TM helix; Region: TM_helix; pfam05552
490759011050	Mechanosensitive ion channel; Region: MS_channel; pfam00924
490759011051	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
490759011052	putative deacylase active site [active]
490759011053	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
490759011054	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
490759011055	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
490759011056	nucleotide binding site/active site [active]
490759011057	HIT family signature motif; other site
490759011058	catalytic residue [active]
490759011059	PAS fold; Region: PAS_4; pfam08448
490759011060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759011061	putative active site [active]
490759011062	heme pocket [chemical binding]; other site
490759011063	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759011064	PAS domain; Region: PAS_9; pfam13426
490759011065	putative active site [active]
490759011066	heme pocket [chemical binding]; other site
490759011067	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759011068	metal binding site [ion binding]; metal-binding site
490759011069	active site
490759011070	I-site; other site
490759011071	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759011072	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
490759011073	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
490759011074	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759011075	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759011076	metal binding site [ion binding]; metal-binding site
490759011077	active site
490759011078	I-site; other site
490759011079	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759011080	transcriptional regulator PhoU; Provisional; Region: PRK11115
490759011081	PhoU domain; Region: PhoU; pfam01895
490759011082	PhoU domain; Region: PhoU; pfam01895
490759011083	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
490759011084	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
490759011085	Walker A/P-loop; other site
490759011086	ATP binding site [chemical binding]; other site
490759011087	Q-loop/lid; other site
490759011088	ABC transporter signature motif; other site
490759011089	Walker B; other site
490759011090	D-loop; other site
490759011091	H-loop/switch region; other site
490759011092	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
490759011093	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
490759011094	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759011095	dimer interface [polypeptide binding]; other site
490759011096	conserved gate region; other site
490759011097	putative PBP binding loops; other site
490759011098	ABC-ATPase subunit interface; other site
490759011099	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
490759011100	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
490759011101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
490759011102	dimer interface [polypeptide binding]; other site
490759011103	conserved gate region; other site
490759011104	putative PBP binding loops; other site
490759011105	ABC-ATPase subunit interface; other site
490759011106	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
490759011107	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
490759011108	Bacitracin resistance protein BacA; Region: BacA; pfam02673
490759011109	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
490759011110	Part of AAA domain; Region: AAA_19; pfam13245
490759011111	Family description; Region: UvrD_C_2; pfam13538
490759011112	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
490759011113	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
490759011114	tetramerization interface [polypeptide binding]; other site
490759011115	NAD(P) binding site [chemical binding]; other site
490759011116	catalytic residues [active]
490759011117	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
490759011118	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
490759011119	active site
490759011120	Zn binding site [ion binding]; other site
490759011121	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
490759011122	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
490759011123	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
490759011124	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
490759011125	Helicase; Region: Helicase_RecD; pfam05127
490759011126	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
490759011127	Coenzyme A binding pocket [chemical binding]; other site
490759011128	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
490759011129	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
490759011130	Part of AAA domain; Region: AAA_19; pfam13245
490759011131	Family description; Region: UvrD_C_2; pfam13538
490759011132	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
490759011133	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
490759011134	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
490759011135	ligand binding site [chemical binding]; other site
490759011136	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
490759011137	hydroxyglutarate oxidase; Provisional; Region: PRK11728
490759011138	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
490759011139	active site
490759011140	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
490759011141	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
490759011142	Response regulator receiver domain; Region: Response_reg; pfam00072
490759011143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759011144	active site
490759011145	phosphorylation site [posttranslational modification]
490759011146	intermolecular recognition site; other site
490759011147	dimerization interface [polypeptide binding]; other site
490759011148	HDOD domain; Region: HDOD; pfam08668
490759011149	aconitate hydratase; Validated; Region: PRK09277
490759011150	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
490759011151	substrate binding site [chemical binding]; other site
490759011152	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
490759011153	ligand binding site [chemical binding]; other site
490759011154	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
490759011155	substrate binding site [chemical binding]; other site
490759011156	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034
490759011157	Rhomboid family; Region: Rhomboid; pfam01694
490759011158	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
490759011159	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
490759011160	ligand binding site [chemical binding]; other site
490759011161	MAPEG family; Region: MAPEG; cl09190
490759011162	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
490759011163	putative acyl-acceptor binding pocket; other site
490759011164	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
490759011165	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759011166	active site
490759011167	phosphorylation site [posttranslational modification]
490759011168	intermolecular recognition site; other site
490759011169	dimerization interface [polypeptide binding]; other site
490759011170	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
490759011171	DNA binding site [nucleotide binding]
490759011172	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
490759011173	proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785
490759011174	putative ligand binding site [chemical binding]; other site
490759011175	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
490759011176	dimer interface [polypeptide binding]; other site
490759011177	phosphorylation site [posttranslational modification]
490759011178	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759011179	ATP binding site [chemical binding]; other site
490759011180	Mg2+ binding site [ion binding]; other site
490759011181	G-X-G motif; other site
490759011182	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
490759011183	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
490759011184	Walker A motif; other site
490759011185	ATP binding site [chemical binding]; other site
490759011186	Walker B motif; other site
490759011187	DNA ligase; Provisional; Region: PRK09125
490759011188	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
490759011189	DNA binding site [nucleotide binding]
490759011190	active site
490759011191	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
490759011192	DNA binding site [nucleotide binding]
490759011193	Acyl CoA binding protein; Region: ACBP; pfam00887
490759011194	acyl-CoA binding pocket [chemical binding]; other site
490759011195	CoA binding site [chemical binding]; other site
490759011196	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
490759011197	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
490759011198	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
490759011199	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
490759011200	HAMP domain; Region: HAMP; pfam00672
490759011201	dimerization interface [polypeptide binding]; other site
490759011202	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
490759011203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759011204	ATP binding site [chemical binding]; other site
490759011205	Mg2+ binding site [ion binding]; other site
490759011206	G-X-G motif; other site
490759011207	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
490759011208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759011209	active site
490759011210	phosphorylation site [posttranslational modification]
490759011211	intermolecular recognition site; other site
490759011212	dimerization interface [polypeptide binding]; other site
490759011213	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
490759011214	DNA binding site [nucleotide binding]
490759011215	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
490759011216	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
490759011217	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
490759011218	DNA binding residues [nucleotide binding]
490759011219	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
490759011220	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
490759011221	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
490759011222	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
490759011223	Walker A/P-loop; other site
490759011224	ATP binding site [chemical binding]; other site
490759011225	Q-loop/lid; other site
490759011226	ABC transporter signature motif; other site
490759011227	Walker B; other site
490759011228	D-loop; other site
490759011229	H-loop/switch region; other site
490759011230	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
490759011231	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
490759011232	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
490759011233	P loop; other site
490759011234	GTP binding site [chemical binding]; other site
490759011235	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
490759011236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759011237	S-adenosylmethionine binding site [chemical binding]; other site
490759011238	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
490759011239	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
490759011240	DNA binding site [nucleotide binding]
490759011241	catalytic residue [active]
490759011242	H2TH interface [polypeptide binding]; other site
490759011243	putative catalytic residues [active]
490759011244	turnover-facilitating residue; other site
490759011245	intercalation triad [nucleotide binding]; other site
490759011246	8OG recognition residue [nucleotide binding]; other site
490759011247	putative reading head residues; other site
490759011248	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
490759011249	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
490759011250	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
490759011251	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
490759011252	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759011253	motif II; other site
490759011254	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
490759011255	RNA binding surface [nucleotide binding]; other site
490759011256	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
490759011257	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
490759011258	dimerization interface [polypeptide binding]; other site
490759011259	domain crossover interface; other site
490759011260	redox-dependent activation switch; other site
490759011261	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
490759011262	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
490759011263	active site
490759011264	substrate-binding site [chemical binding]; other site
490759011265	metal-binding site [ion binding]
490759011266	ATP binding site [chemical binding]; other site
490759011267	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
490759011268	dihydroorotase; Validated; Region: pyrC; PRK09357
490759011269	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
490759011270	active site
490759011271	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
490759011272	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
490759011273	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
490759011274	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
490759011275	active site
490759011276	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
490759011277	hypothetical protein; Validated; Region: PRK00228
490759011278	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
490759011279	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
490759011280	glutathione synthetase; Provisional; Region: PRK05246
490759011281	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
490759011282	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
490759011283	Response regulator receiver domain; Region: Response_reg; pfam00072
490759011284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759011285	active site
490759011286	phosphorylation site [posttranslational modification]
490759011287	intermolecular recognition site; other site
490759011288	dimerization interface [polypeptide binding]; other site
490759011289	Response regulator receiver domain; Region: Response_reg; pfam00072
490759011290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759011291	active site
490759011292	phosphorylation site [posttranslational modification]
490759011293	intermolecular recognition site; other site
490759011294	dimerization interface [polypeptide binding]; other site
490759011295	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
490759011296	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
490759011297	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
490759011298	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759011299	dimer interface [polypeptide binding]; other site
490759011300	putative CheW interface [polypeptide binding]; other site
490759011301	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
490759011302	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
490759011303	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
490759011304	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
490759011305	putative binding surface; other site
490759011306	active site
490759011307	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
490759011308	putative binding surface; other site
490759011309	active site
490759011310	Hpt domain; Region: Hpt; pfam01627
490759011311	putative binding surface; other site
490759011312	active site
490759011313	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
490759011314	putative binding surface; other site
490759011315	active site
490759011316	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
490759011317	putative binding surface; other site
490759011318	active site
490759011319	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
490759011320	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
490759011321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
490759011322	ATP binding site [chemical binding]; other site
490759011323	Mg2+ binding site [ion binding]; other site
490759011324	G-X-G motif; other site
490759011325	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
490759011326	Response regulator receiver domain; Region: Response_reg; pfam00072
490759011327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
490759011328	active site
490759011329	phosphorylation site [posttranslational modification]
490759011330	intermolecular recognition site; other site
490759011331	dimerization interface [polypeptide binding]; other site
490759011332	CheB methylesterase; Region: CheB_methylest; pfam01339
490759011333	CheW-like domain; Region: CheW; pfam01584
490759011334	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
490759011335	metal binding site 2 [ion binding]; metal-binding site
490759011336	putative DNA binding helix; other site
490759011337	metal binding site 1 [ion binding]; metal-binding site
490759011338	dimer interface [polypeptide binding]; other site
490759011339	structural Zn2+ binding site [ion binding]; other site
490759011340	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
490759011341	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
490759011342	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
490759011343	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
490759011344	ABC-ATPase subunit  interface; other site
490759011345	dimer interface [polypeptide binding]; other site
490759011346	putative PBP binding regions; other site
490759011347	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759011348	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
490759011349	homodecamer interface [polypeptide binding]; other site
490759011350	GTP cyclohydrolase I; Provisional; Region: PLN03044
490759011351	active site
490759011352	putative catalytic site residues [active]
490759011353	zinc binding site [ion binding]; other site
490759011354	GTP-CH-I/GFRP interaction surface; other site
490759011355	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
490759011356	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
490759011357	Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787
490759011358	DNA binding residues [nucleotide binding]
490759011359	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
490759011360	dimer interface [polypeptide binding]; other site
490759011361	copper exporting ATPase; Provisional; Region: copA; PRK10671
490759011362	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
490759011363	metal-binding site [ion binding]
490759011364	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
490759011365	metal-binding site [ion binding]
490759011366	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
490759011367	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759011368	motif II; other site
490759011369	Predicted metal-binding protein [General function prediction only]; Region: COG3019
490759011370	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759011371	dimerization interface [polypeptide binding]; other site
490759011372	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759011373	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759011374	metal binding site [ion binding]; metal-binding site
490759011375	active site
490759011376	I-site; other site
490759011377	VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358
490759011378	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
490759011379	RNA binding site [nucleotide binding]; other site
490759011380	RNB domain; Region: RNB; pfam00773
490759011381	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
490759011382	RNA binding site [nucleotide binding]; other site
490759011383	Transcriptional regulator [Transcription]; Region: LysR; COG0583
490759011384	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
490759011385	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
490759011386	substrate binding pocket [chemical binding]; other site
490759011387	dimerization interface [polypeptide binding]; other site
490759011388	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
490759011389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759011390	putative substrate translocation pore; other site
490759011391	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
490759011392	dimer interface [polypeptide binding]; other site
490759011393	catalytic triad [active]
490759011394	peroxidatic and resolving cysteines [active]
490759011395	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
490759011396	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
490759011397	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
490759011398	active site
490759011399	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
490759011400	nudix motif; other site
490759011401	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
490759011402	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
490759011403	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
490759011404	putative active site [active]
490759011405	Zn binding site [ion binding]; other site
490759011406	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
490759011407	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
490759011408	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759011409	homodimer interface [polypeptide binding]; other site
490759011410	catalytic residue [active]
490759011411	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
490759011412	UbiA prenyltransferase family; Region: UbiA; pfam01040
490759011413	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
490759011414	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
490759011415	active site
490759011416	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
490759011417	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
490759011418	MarC family integral membrane protein; Region: MarC; pfam01914
490759011419	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
490759011420	Ion channel; Region: Ion_trans_2; pfam07885
490759011421	OmpW family; Region: OmpW; cl17427
490759011422	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
490759011423	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
490759011424	ATP binding site [chemical binding]; other site
490759011425	Mg++ binding site [ion binding]; other site
490759011426	motif III; other site
490759011427	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
490759011428	nucleotide binding region [chemical binding]; other site
490759011429	ATP-binding site [chemical binding]; other site
490759011430	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
490759011431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759011432	S-adenosylmethionine binding site [chemical binding]; other site
490759011433	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
490759011434	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
490759011435	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
490759011436	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
490759011437	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
490759011438	catalytic residue [active]
490759011439	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
490759011440	catalytic residues [active]
490759011441	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
490759011442	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
490759011443	Protein of unknown function (DUF3581); Region: DUF3581; pfam12119
490759011444	peroxiredoxin; Region: AhpC; TIGR03137
490759011445	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
490759011446	dimer interface [polypeptide binding]; other site
490759011447	decamer (pentamer of dimers) interface [polypeptide binding]; other site
490759011448	catalytic triad [active]
490759011449	peroxidatic and resolving cysteines [active]
490759011450	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
490759011451	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759011452	S-adenosylmethionine binding site [chemical binding]; other site
490759011453	hypothetical protein; Provisional; Region: PRK11019
490759011454	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
490759011455	DNA-binding site [nucleotide binding]; DNA binding site
490759011456	RNA-binding motif; other site
490759011457	Protein of unknown function, DUF393; Region: DUF393; pfam04134
490759011458	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
490759011459	DctM-like transporters; Region: DctM; pfam06808
490759011460	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
490759011461	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
490759011462	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
490759011463	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
490759011464	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
490759011465	Mechanosensitive ion channel; Region: MS_channel; pfam00924
490759011466	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
490759011467	ThiS interaction site; other site
490759011468	putative active site [active]
490759011469	tetramer interface [polypeptide binding]; other site
490759011470	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
490759011471	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
490759011472	active site
490759011473	non-prolyl cis peptide bond; other site
490759011474	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
490759011475	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
490759011476	NAD(P) binding site [chemical binding]; other site
490759011477	active site
490759011478	Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476
490759011479	Na binding site [ion binding]; other site
490759011480	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
490759011481	SOUL heme-binding protein; Region: SOUL; pfam04832
490759011482	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
490759011483	Ligand Binding Site [chemical binding]; other site
490759011484	Peptidase family M23; Region: Peptidase_M23; pfam01551
490759011485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
490759011486	short chain dehydrogenase; Provisional; Region: PRK07454
490759011487	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
490759011488	NADP binding site [chemical binding]; other site
490759011489	homodimer interface [polypeptide binding]; other site
490759011490	active site
490759011491	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
490759011492	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
490759011493	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
490759011494	tetramer interface [polypeptide binding]; other site
490759011495	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759011496	catalytic residue [active]
490759011497	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
490759011498	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
490759011499	non-specific DNA binding site [nucleotide binding]; other site
490759011500	salt bridge; other site
490759011501	sequence-specific DNA binding site [nucleotide binding]; other site
490759011502	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
490759011503	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
490759011504	S-adenosylmethionine binding site [chemical binding]; other site
490759011505	PAS domain S-box; Region: sensory_box; TIGR00229
490759011506	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
490759011507	putative active site [active]
490759011508	heme pocket [chemical binding]; other site
490759011509	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759011510	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759011511	metal binding site [ion binding]; metal-binding site
490759011512	active site
490759011513	I-site; other site
490759011514	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
490759011515	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759011516	metal binding site [ion binding]; metal-binding site
490759011517	active site
490759011518	I-site; other site
490759011519	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
490759011520	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
490759011521	active site
490759011522	Zn binding site [ion binding]; other site
490759011523	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
490759011524	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759011525	Major Facilitator Superfamily; Region: MFS_1; pfam07690
490759011526	putative substrate translocation pore; other site
490759011527	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
490759011528	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
490759011529	active site
490759011530	motif I; other site
490759011531	motif II; other site
490759011532	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
490759011533	glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398
490759011534	active site
490759011535	homotetramer interface [polypeptide binding]; other site
490759011536	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
490759011537	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
490759011538	active site
490759011539	homodimer interface [polypeptide binding]; other site
490759011540	catalytic site [active]
490759011541	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
490759011542	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
490759011543	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
490759011544	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
490759011545	metal binding site [ion binding]; metal-binding site
490759011546	active site
490759011547	I-site; other site
490759011548	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
490759011549	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
490759011550	putative active site [active]
490759011551	metal binding site [ion binding]; metal-binding site
490759011552	hypothetical protein; Provisional; Region: PRK02237
490759011553	Transcriptional regulators [Transcription]; Region: MarR; COG1846
490759011554	MarR family; Region: MarR; pfam01047
490759011555	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
490759011556	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
490759011557	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
490759011558	inhibitor site; inhibition site
490759011559	active site
490759011560	dimer interface [polypeptide binding]; other site
490759011561	catalytic residue [active]
490759011562	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
490759011563	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
490759011564	active site
490759011565	catalytic triad [active]
490759011566	oxyanion hole [active]
490759011567	Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356
490759011568	substrate binding site [chemical binding]; other site
490759011569	Protein of unknown function (DUF521); Region: DUF521; pfam04412
490759011570	Putative Aconitase X catalytic domain; Region: AcnX; cd01355
490759011571	substrate binding site [chemical binding]; other site
490759011572	ligand binding site [chemical binding]; other site
490759011573	hypothetical protein; Provisional; Region: PRK07877
490759011574	MarR family; Region: MarR_2; pfam12802
490759011575	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
490759011576	aromatic arch; other site
490759011577	DCoH dimer interaction site [polypeptide binding]; other site
490759011578	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
490759011579	DCoH tetramer interaction site [polypeptide binding]; other site
490759011580	substrate binding site [chemical binding]; other site
490759011581	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
490759011582	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
490759011583	catalytic residue [active]
490759011584	Phospholipid methyltransferase; Region: PEMT; cl17370
490759011585	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
490759011586	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
490759011587	Electron transfer DM13; Region: DM13; pfam10517
490759011588	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
490759011589	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
490759011590	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
490759011591	HlyD family secretion protein; Region: HlyD_3; pfam13437
490759011592	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
490759011593	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
490759011594	sequence-specific DNA binding site [nucleotide binding]; other site
490759011595	salt bridge; other site
490759011596	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
490759011597	Peptidase M15; Region: Peptidase_M15_3; cl01194
490759011598	Protein of unknown function (DUF3237); Region: DUF3237; cl07905
490759011599	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
490759011600	YrhK-like protein; Region: YrhK; pfam14145
490759011601	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
490759011602	FAD binding domain; Region: FAD_binding_4; pfam01565
490759011603	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
490759011604	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
490759011605	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
490759011606	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
490759011607	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
490759011608	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
490759011609	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
490759011610	HlyD family secretion protein; Region: HlyD_3; pfam13437
490759011611	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
490759011612	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
490759011613	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
490759011614	active site
490759011615	DNA binding site [nucleotide binding]
490759011616	Int/Topo IB signature motif; other site
490759011617	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
490759011618	dimer interface [polypeptide binding]; other site
490759011619	putative radical transfer pathway; other site
490759011620	diiron center [ion binding]; other site
490759011621	tyrosyl radical; other site
490759011622	ATP cone domain; Region: ATP-cone; pfam03477
490759011623	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
490759011624	Class I ribonucleotide reductase; Region: RNR_I; cd01679
490759011625	active site
490759011626	dimer interface [polypeptide binding]; other site
490759011627	catalytic residues [active]
490759011628	effector binding site; other site
490759011629	R2 peptide binding site; other site
490759011630	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
490759011631	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
490759011632	FAD binding domain; Region: FAD_binding_4; pfam01565
490759011633	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
490759011634	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
490759011635	Cysteine-rich domain; Region: CCG; pfam02754
490759011636	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
490759011637	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
490759011638	active site
490759011639	substrate binding site [chemical binding]; other site
490759011640	FMN binding site [chemical binding]; other site
490759011641	putative catalytic residues [active]
490759011642	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
490759011643	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759011644	DNA-binding site [nucleotide binding]; DNA binding site
490759011645	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
490759011646	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
490759011647	RNA recognition motif; Region: RRM; smart00360
490759011648	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
490759011649	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
490759011650	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
490759011651	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
490759011652	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
490759011653	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
490759011654	DctM-like transporters; Region: DctM; pfam06808
490759011655	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
490759011656	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
490759011657	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759011658	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
490759011659	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
490759011660	putative DNA binding site [nucleotide binding]; other site
490759011661	putative Zn2+ binding site [ion binding]; other site
490759011662	AsnC family; Region: AsnC_trans_reg; pfam01037
490759011663	Flagellin N-methylase; Region: FliB; cl00497
490759011664	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
490759011665	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
490759011666	homotrimer interaction site [polypeptide binding]; other site
490759011667	putative active site [active]
490759011668	Cache domain; Region: Cache_1; pfam02743
490759011669	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
490759011670	dimerization interface [polypeptide binding]; other site
490759011671	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
490759011672	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
490759011673	dimer interface [polypeptide binding]; other site
490759011674	putative CheW interface [polypeptide binding]; other site
490759011675	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
490759011676	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
490759011677	DNA-binding site [nucleotide binding]; DNA binding site
490759011678	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
490759011679	pyridoxal 5'-phosphate binding site [chemical binding]; other site
490759011680	homodimer interface [polypeptide binding]; other site
490759011681	catalytic residue [active]
490759011682	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
490759011683	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
490759011684	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
490759011685	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
490759011686	Metallopeptidase family M24; Region: Peptidase_M24; pfam00557
490759011687	active site
490759011688	DctM-like transporters; Region: DctM; pfam06808
490759011689	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
490759011690	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
490759011691	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
490759011692	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
490759011693	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
490759011694	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
490759011695	metal binding site [ion binding]; metal-binding site
490759011696	putative dimer interface [polypeptide binding]; other site
490759011697	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
490759011698	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
490759011699	putative DNA binding site [nucleotide binding]; other site
490759011700	putative Zn2+ binding site [ion binding]; other site
490759011701	AsnC family; Region: AsnC_trans_reg; pfam01037
490759011702	diaminopropionate ammonia-lyase; Provisional; Region: PRK08206
490759011703	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
490759011704	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
490759011705	catalytic residue [active]
490759011706	DEAD-like helicases superfamily; Region: DEXDc; smart00487
490759011707	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
490759011708	ATP binding site [chemical binding]; other site
490759011709	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
490759011710	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
490759011711	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
490759011712	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
490759011713	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
490759011714	ATP binding site [chemical binding]; other site
490759011715	putative Mg++ binding site [ion binding]; other site
490759011716	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
490759011717	Methyltransferase domain; Region: Methyltransf_26; pfam13659
490759011718	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
490759011719	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
490759011720	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
490759011721	Fic/DOC family; Region: Fic; pfam02661
490759011722	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
490759011723	putative active site [active]
490759011724	putative NTP binding site [chemical binding]; other site
490759011725	putative nucleic acid binding site [nucleotide binding]; other site
490759011726	TniQ; Region: TniQ; pfam06527
490759011727	AAA domain; Region: AAA_22; pfam13401
490759011728	Tn7 transposition regulator TnsC; Region: Tn7_TnsC_Int; pfam11426
490759011729	Integrase core domain; Region: rve; pfam00665
490759011730	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
490759011731	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
490759011732	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
490759011733	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
490759011734	glutaminase active site [active]
490759011735	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
490759011736	dimer interface [polypeptide binding]; other site
490759011737	active site
490759011738	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
490759011739	dimer interface [polypeptide binding]; other site
490759011740	active site
490759011741	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
490759011742	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
490759011743	Substrate binding site; other site
490759011744	Mg++ binding site; other site
490759011745	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
490759011746	active site
490759011747	substrate binding site [chemical binding]; other site
490759011748	CoA binding site [chemical binding]; other site
490759011749	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
490759011750	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
490759011751	gamma subunit interface [polypeptide binding]; other site
490759011752	epsilon subunit interface [polypeptide binding]; other site
490759011753	LBP interface [polypeptide binding]; other site
490759011754	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
490759011755	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
490759011756	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
490759011757	alpha subunit interaction interface [polypeptide binding]; other site
490759011758	Walker A motif; other site
490759011759	ATP binding site [chemical binding]; other site
490759011760	Walker B motif; other site
490759011761	inhibitor binding site; inhibition site
490759011762	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
490759011763	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
490759011764	core domain interface [polypeptide binding]; other site
490759011765	delta subunit interface [polypeptide binding]; other site
490759011766	epsilon subunit interface [polypeptide binding]; other site
490759011767	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
490759011768	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
490759011769	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
490759011770	beta subunit interaction interface [polypeptide binding]; other site
490759011771	Walker A motif; other site
490759011772	ATP binding site [chemical binding]; other site
490759011773	Walker B motif; other site
490759011774	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
490759011775	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
490759011776	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
490759011777	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
490759011778	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
490759011779	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
490759011780	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
490759011781	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
490759011782	ATP synthase I chain; Region: ATP_synt_I; cl09170
490759011783	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
490759011784	ParB-like nuclease domain; Region: ParBc; pfam02195
490759011785	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
490759011786	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
490759011787	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
490759011788	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
490759011789	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
490759011790	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
490759011791	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
490759011792	Major Facilitator Superfamily; Region: MFS_1; pfam07690
490759011793	putative substrate translocation pore; other site
490759011794	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
490759011795	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
490759011796	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
490759011797	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
490759011798	HlyD family secretion protein; Region: HlyD_3; pfam13437
490759011799	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
490759011800	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
490759011801	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
490759011802	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
490759011803	hypothetical protein; Provisional; Region: PRK01617
490759011804	SEC-C motif; Region: SEC-C; pfam02810
490759011805	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
490759011806	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
490759011807	NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
490759011808	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
490759011809	NAD(P) binding site [chemical binding]; other site
490759011810	catalytic residues [active]
490759011811	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
490759011812	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
490759011813	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
490759011814	trmE is a tRNA modification GTPase; Region: trmE; cd04164
490759011815	G1 box; other site
490759011816	GTP/Mg2+ binding site [chemical binding]; other site
490759011817	Switch I region; other site
490759011818	G2 box; other site
490759011819	Switch II region; other site
490759011820	G3 box; other site
490759011821	G4 box; other site
490759011822	G5 box; other site
490759011823	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
490759011824	membrane protein insertase; Provisional; Region: PRK01318
490759011825	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
490759011826	Haemolytic domain; Region: Haemolytic; pfam01809
490759011827	Ribonuclease P; Region: Ribonuclease_P; cl00457