-- dump date 20140619_140218 -- class Genbank::misc_feature -- table misc_feature_note -- id note 643867000001 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 643867000002 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 643867000003 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 643867000004 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 643867000005 Initiator Replication protein; Region: Rep_3; pfam01051 643867000006 DnaA N-terminal domain; Region: DnaA_N; pfam11638 643867000007 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 643867000008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867000009 Walker A motif; other site 643867000010 ATP binding site [chemical binding]; other site 643867000011 Walker B motif; other site 643867000012 arginine finger; other site 643867000013 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 643867000014 DnaA box-binding interface [nucleotide binding]; other site 643867000015 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 643867000016 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 643867000017 active site 643867000018 catalytic site [active] 643867000019 substrate binding site [chemical binding]; other site 643867000020 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 643867000021 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 643867000022 GIY-YIG motif/motif A; other site 643867000023 active site 643867000024 catalytic site [active] 643867000025 putative DNA binding site [nucleotide binding]; other site 643867000026 metal binding site [ion binding]; metal-binding site 643867000027 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 643867000028 oligomeric interface; other site 643867000029 putative active site [active] 643867000030 homodimer interface [polypeptide binding]; other site 643867000031 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 643867000032 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 643867000033 C-terminal peptidase (prc); Region: prc; TIGR00225 643867000034 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 643867000035 protein binding site [polypeptide binding]; other site 643867000036 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 643867000037 Catalytic dyad [active] 643867000038 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 643867000039 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 643867000040 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 643867000041 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 643867000042 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 643867000043 active site 643867000044 catalytic residues [active] 643867000045 metal binding site [ion binding]; metal-binding site 643867000046 TPR repeat; Region: TPR_11; pfam13414 643867000047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000048 binding surface 643867000049 TPR repeat; Region: TPR_11; pfam13414 643867000050 TPR motif; other site 643867000051 TPR repeat; Region: TPR_11; pfam13414 643867000052 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 643867000053 PHB binding site; other site 643867000054 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 643867000055 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 643867000056 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 643867000057 catalytic site [active] 643867000058 putative active site [active] 643867000059 putative substrate binding site [chemical binding]; other site 643867000060 ATPase involved in DNA repair; Region: DUF3686; pfam12458 643867000061 AAA domain; Region: AAA_22; pfam13401 643867000062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867000063 Walker A motif; other site 643867000064 ATP binding site [chemical binding]; other site 643867000065 Walker B motif; other site 643867000066 arginine finger; other site 643867000067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 643867000068 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 643867000069 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 643867000070 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 643867000071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867000072 non-specific DNA binding site [nucleotide binding]; other site 643867000073 salt bridge; other site 643867000074 sequence-specific DNA binding site [nucleotide binding]; other site 643867000075 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 643867000076 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 643867000077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 643867000078 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867000079 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867000080 ligand binding site [chemical binding]; other site 643867000081 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 643867000082 active site 643867000083 catalytic triad [active] 643867000084 oxyanion hole [active] 643867000085 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 643867000086 DsrE/DsrF-like family; Region: DrsE; pfam02635 643867000087 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 643867000088 putative ligand binding site [chemical binding]; other site 643867000089 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 643867000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867000091 active site 643867000092 phosphorylation site [posttranslational modification] 643867000093 intermolecular recognition site; other site 643867000094 PAS domain S-box; Region: sensory_box; TIGR00229 643867000095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867000096 putative active site [active] 643867000097 heme pocket [chemical binding]; other site 643867000098 CheB methylesterase; Region: CheB_methylest; pfam01339 643867000099 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 643867000100 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 643867000101 PAS domain; Region: PAS_10; pfam13596 643867000102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867000103 PAS domain; Region: PAS_9; pfam13426 643867000104 putative active site [active] 643867000105 heme pocket [chemical binding]; other site 643867000106 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 643867000107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867000108 putative active site [active] 643867000109 heme pocket [chemical binding]; other site 643867000110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000111 ATP binding site [chemical binding]; other site 643867000112 Mg2+ binding site [ion binding]; other site 643867000113 G-X-G motif; other site 643867000114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867000115 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 643867000116 putative active site [active] 643867000117 heme pocket [chemical binding]; other site 643867000118 PAS fold; Region: PAS_4; pfam08448 643867000119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867000120 putative active site [active] 643867000121 heme pocket [chemical binding]; other site 643867000122 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 643867000123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867000124 putative active site [active] 643867000125 heme pocket [chemical binding]; other site 643867000126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867000127 dimer interface [polypeptide binding]; other site 643867000128 phosphorylation site [posttranslational modification] 643867000129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000130 ATP binding site [chemical binding]; other site 643867000131 Mg2+ binding site [ion binding]; other site 643867000132 G-X-G motif; other site 643867000133 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 643867000134 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 643867000135 folate binding site [chemical binding]; other site 643867000136 NADP+ binding site [chemical binding]; other site 643867000137 Fructosamine kinase; Region: Fructosamin_kin; cl17579 643867000138 Phosphotransferase enzyme family; Region: APH; pfam01636 643867000139 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 643867000140 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 643867000141 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 643867000142 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 643867000143 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 643867000144 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 643867000145 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 643867000146 active site 643867000147 cysteine synthase B; Region: cysM; TIGR01138 643867000148 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 643867000149 dimer interface [polypeptide binding]; other site 643867000150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867000151 catalytic residue [active] 643867000152 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 643867000153 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 643867000154 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 643867000155 serine O-acetyltransferase; Region: cysE; TIGR01172 643867000156 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 643867000157 trimer interface [polypeptide binding]; other site 643867000158 active site 643867000159 substrate binding site [chemical binding]; other site 643867000160 CoA binding site [chemical binding]; other site 643867000161 Pirin; Region: Pirin; pfam02678 643867000162 Pirin-related protein [General function prediction only]; Region: COG1741 643867000163 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 643867000164 Ion transport protein; Region: Ion_trans; pfam00520 643867000165 Ion channel; Region: Ion_trans_2; pfam07885 643867000166 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 643867000167 Double zinc ribbon; Region: DZR; pfam12773 643867000168 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 643867000169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 643867000170 substrate binding pocket [chemical binding]; other site 643867000171 membrane-bound complex binding site; other site 643867000172 hinge residues; other site 643867000173 PAS domain S-box; Region: sensory_box; TIGR00229 643867000174 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867000175 putative active site [active] 643867000176 heme pocket [chemical binding]; other site 643867000177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867000178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 643867000179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000180 ATP binding site [chemical binding]; other site 643867000181 Mg2+ binding site [ion binding]; other site 643867000182 G-X-G motif; other site 643867000183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000184 binding surface 643867000185 TPR motif; other site 643867000186 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867000189 binding surface 643867000190 TPR motif; other site 643867000191 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867000193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000194 ATP binding site [chemical binding]; other site 643867000195 Mg2+ binding site [ion binding]; other site 643867000196 G-X-G motif; other site 643867000197 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 643867000198 Response regulator receiver domain; Region: Response_reg; pfam00072 643867000199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867000200 active site 643867000201 phosphorylation site [posttranslational modification] 643867000202 intermolecular recognition site; other site 643867000203 dimerization interface [polypeptide binding]; other site 643867000204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867000205 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 643867000206 Walker A motif; other site 643867000207 ATP binding site [chemical binding]; other site 643867000208 Walker B motif; other site 643867000209 arginine finger; other site 643867000210 Smr domain; Region: Smr; pfam01713 643867000211 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 643867000212 DNA photolyase; Region: DNA_photolyase; pfam00875 643867000213 Family of unknown function (DUF490); Region: DUF490; pfam04357 643867000214 Family of unknown function (DUF490); Region: DUF490; pfam04357 643867000215 UGMP family protein; Validated; Region: PRK09604 643867000216 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 643867000217 Predicted thioesterase [General function prediction only]; Region: COG5496 643867000218 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 643867000219 SmpB-tmRNA interface; other site 643867000220 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 643867000221 NlpC/P60 family; Region: NLPC_P60; pfam00877 643867000222 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 643867000223 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 643867000224 active site 643867000225 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 643867000226 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 643867000227 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 643867000228 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 643867000229 Sulfatase; Region: Sulfatase; pfam00884 643867000230 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 643867000231 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 643867000232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 643867000233 FeS/SAM binding site; other site 643867000234 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 643867000235 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 643867000236 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 643867000237 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 643867000238 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 643867000239 Walker A/P-loop; other site 643867000240 ATP binding site [chemical binding]; other site 643867000241 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 643867000242 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 643867000243 ABC transporter signature motif; other site 643867000244 Walker B; other site 643867000245 D-loop; other site 643867000246 H-loop/switch region; other site 643867000247 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 643867000248 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 643867000249 Penicillinase repressor; Region: Pencillinase_R; pfam03965 643867000250 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 643867000251 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 643867000252 TrkA-N domain; Region: TrkA_N; pfam02254 643867000253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000254 TPR motif; other site 643867000255 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000256 binding surface 643867000257 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867000259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000260 ATP binding site [chemical binding]; other site 643867000261 Mg2+ binding site [ion binding]; other site 643867000262 G-X-G motif; other site 643867000263 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 643867000264 ADP-ribose binding site [chemical binding]; other site 643867000265 dimer interface [polypeptide binding]; other site 643867000266 active site 643867000267 nudix motif; other site 643867000268 metal binding site [ion binding]; metal-binding site 643867000269 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 643867000270 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 643867000271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867000272 homodimer interface [polypeptide binding]; other site 643867000273 catalytic residue [active] 643867000274 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 643867000275 histidinol dehydrogenase; Region: hisD; TIGR00069 643867000276 NAD binding site [chemical binding]; other site 643867000277 dimerization interface [polypeptide binding]; other site 643867000278 product binding site; other site 643867000279 substrate binding site [chemical binding]; other site 643867000280 zinc binding site [ion binding]; other site 643867000281 catalytic residues [active] 643867000282 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 643867000283 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 643867000284 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 643867000285 Protein of unknown function (DUF962); Region: DUF962; cl01879 643867000286 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 643867000287 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 643867000288 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 643867000289 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 643867000290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 643867000291 active site 643867000292 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 643867000293 Low molecular weight phosphatase family; Region: LMWPc; cd00115 643867000294 active site 643867000295 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 643867000296 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 643867000297 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 643867000298 active site 643867000299 metal binding site [ion binding]; metal-binding site 643867000300 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 643867000301 mce related protein; Region: MCE; pfam02470 643867000302 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 643867000303 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 643867000304 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 643867000305 FOG: WD40 repeat [General function prediction only]; Region: COG2319 643867000306 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 643867000307 structural tetrad; other site 643867000308 DivIVA protein; Region: DivIVA; pfam05103 643867000309 DivIVA domain; Region: DivI1A_domain; TIGR03544 643867000310 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 643867000311 active site 643867000312 urocanate hydratase; Provisional; Region: PRK05414 643867000313 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 643867000314 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 643867000315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 643867000316 putative DNA binding site [nucleotide binding]; other site 643867000317 putative Zn2+ binding site [ion binding]; other site 643867000318 AsnC family; Region: AsnC_trans_reg; pfam01037 643867000319 methionine gamma-lyase; Validated; Region: PRK07049 643867000320 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 643867000321 homodimer interface [polypeptide binding]; other site 643867000322 substrate-cofactor binding pocket; other site 643867000323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867000324 catalytic residue [active] 643867000325 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 643867000326 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 643867000327 Sulfate transporter family; Region: Sulfate_transp; pfam00916 643867000328 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 643867000329 Bacterial Ig-like domain; Region: Big_5; pfam13205 643867000330 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 643867000331 Helix-turn-helix domain; Region: HTH_18; pfam12833 643867000332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 643867000333 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 643867000334 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 643867000335 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 643867000336 Putative esterase; Region: Esterase; pfam00756 643867000337 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 643867000338 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 643867000339 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 643867000340 active site 643867000341 DNA binding site [nucleotide binding] 643867000342 Int/Topo IB signature motif; other site 643867000343 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 643867000344 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 643867000345 NAD(P) binding site [chemical binding]; other site 643867000346 Fic/DOC family; Region: Fic; cl00960 643867000347 replicative DNA helicase; Region: DnaB; TIGR00665 643867000348 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 643867000349 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 643867000350 Walker A motif; other site 643867000351 ATP binding site [chemical binding]; other site 643867000352 Walker B motif; other site 643867000353 DNA binding loops [nucleotide binding] 643867000354 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 643867000355 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 643867000356 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 643867000357 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 643867000358 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 643867000359 active site 643867000360 catalytic site [active] 643867000361 substrate binding site [chemical binding]; other site 643867000362 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 643867000363 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 643867000364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867000365 putative active site [active] 643867000366 heme pocket [chemical binding]; other site 643867000367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867000368 dimer interface [polypeptide binding]; other site 643867000369 phosphorylation site [posttranslational modification] 643867000370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000371 ATP binding site [chemical binding]; other site 643867000372 Mg2+ binding site [ion binding]; other site 643867000373 G-X-G motif; other site 643867000374 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 643867000375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867000376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000377 ATP binding site [chemical binding]; other site 643867000378 Mg2+ binding site [ion binding]; other site 643867000379 G-X-G motif; other site 643867000380 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 643867000381 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 643867000382 transmembrane helices; other site 643867000383 TrkA-C domain; Region: TrkA_C; pfam02080 643867000384 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 643867000385 TrkA-C domain; Region: TrkA_C; pfam02080 643867000386 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 643867000387 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000388 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000390 binding surface 643867000391 TPR motif; other site 643867000392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867000393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867000394 dimer interface [polypeptide binding]; other site 643867000395 phosphorylation site [posttranslational modification] 643867000396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000397 ATP binding site [chemical binding]; other site 643867000398 G-X-G motif; other site 643867000399 DNA helicase, putative; Region: TIGR00376 643867000400 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867000401 ATP binding site [chemical binding]; other site 643867000402 AAA domain; Region: AAA_12; pfam13087 643867000403 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 643867000404 putative catalytic site [active] 643867000405 putative phosphate binding site [ion binding]; other site 643867000406 putative metal binding site [ion binding]; other site 643867000407 DinB superfamily; Region: DinB_2; pfam12867 643867000408 Transcriptional regulators [Transcription]; Region: PurR; COG1609 643867000409 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 643867000410 DNA binding site [nucleotide binding] 643867000411 domain linker motif; other site 643867000412 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 643867000413 dimerization interface [polypeptide binding]; other site 643867000414 ligand binding site [chemical binding]; other site 643867000415 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 643867000416 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867000417 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 643867000418 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867000419 starch binding outer membrane protein SusD; Region: SusD; cl17845 643867000420 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 643867000421 SusD family; Region: SusD; pfam07980 643867000422 Family description; Region: VCBS; pfam13517 643867000423 Family description; Region: VCBS; pfam13517 643867000424 Family description; Region: VCBS; pfam13517 643867000425 Family description; Region: VCBS; pfam13517 643867000426 Family description; Region: VCBS; pfam13517 643867000427 Family description; Region: VCBS; pfam13517 643867000428 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 643867000429 Family description; Region: VCBS; pfam13517 643867000430 Family description; Region: VCBS; pfam13517 643867000431 Family description; Region: VCBS; pfam13517 643867000432 Family description; Region: VCBS; pfam13517 643867000433 Family description; Region: VCBS; pfam13517 643867000434 Family description; Region: VCBS; pfam13517 643867000435 Family description; Region: VCBS; pfam13517 643867000436 Family description; Region: VCBS; pfam13517 643867000437 Family description; Region: VCBS; pfam13517 643867000438 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 643867000439 Family description; Region: VCBS; pfam13517 643867000440 Family description; Region: VCBS; pfam13517 643867000441 Family description; Region: VCBS; pfam13517 643867000442 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 643867000443 active site 643867000444 Trehalase; Region: Trehalase; cl17346 643867000445 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 643867000446 Na binding site [ion binding]; other site 643867000447 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 643867000448 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 643867000449 Ca binding site [ion binding]; other site 643867000450 active site 643867000451 catalytic site [active] 643867000452 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 643867000453 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 643867000454 dimer interface [polypeptide binding]; other site 643867000455 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 643867000456 Na binding site [ion binding]; other site 643867000457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000458 binding surface 643867000459 TPR motif; other site 643867000460 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867000461 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867000462 ligand binding site [chemical binding]; other site 643867000463 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 643867000464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867000465 TPR motif; other site 643867000466 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 643867000467 active site 643867000468 DNA binding site [nucleotide binding] 643867000469 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867000470 Ligand Binding Site [chemical binding]; other site 643867000471 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867000472 Ligand Binding Site [chemical binding]; other site 643867000473 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867000474 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867000475 ligand binding site [chemical binding]; other site 643867000476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867000477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 643867000478 Deoxyhypusine synthase; Region: DS; cl00826 643867000479 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 643867000480 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 643867000481 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 643867000482 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 643867000483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000484 binding surface 643867000485 TPR motif; other site 643867000486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000487 binding surface 643867000488 TPR repeat; Region: TPR_11; pfam13414 643867000489 TPR motif; other site 643867000490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867000491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867000492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867000493 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 643867000494 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 643867000495 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867000496 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 643867000497 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 643867000498 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 643867000499 starch binding outer membrane protein SusD; Region: SusD; cd08977 643867000500 SusD family; Region: SusD; pfam07980 643867000501 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 643867000502 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867000503 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867000504 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867000505 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 643867000506 active site 643867000507 catalytic residues [active] 643867000508 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 643867000509 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 643867000510 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 643867000511 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 643867000512 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 643867000513 active site 643867000514 catalytic residues [active] 643867000515 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 643867000516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867000517 putative substrate translocation pore; other site 643867000518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867000519 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 643867000520 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 643867000521 putative acyl-acceptor binding pocket; other site 643867000522 methionine sulfoxide reductase B; Provisional; Region: PRK00222 643867000523 SelR domain; Region: SelR; pfam01641 643867000524 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 643867000525 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 643867000526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867000527 Walker A/P-loop; other site 643867000528 ATP binding site [chemical binding]; other site 643867000529 Q-loop/lid; other site 643867000530 ABC transporter signature motif; other site 643867000531 Walker B; other site 643867000532 D-loop; other site 643867000533 H-loop/switch region; other site 643867000534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 643867000535 putative PBP binding loops; other site 643867000536 dimer interface [polypeptide binding]; other site 643867000537 ABC-ATPase subunit interface; other site 643867000538 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867000539 Ligand Binding Site [chemical binding]; other site 643867000540 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867000541 Ligand Binding Site [chemical binding]; other site 643867000542 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 643867000543 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 643867000544 putative rRNA binding site [nucleotide binding]; other site 643867000545 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 643867000546 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 643867000547 active site 643867000548 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 643867000549 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 643867000550 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 643867000551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867000552 Walker A/P-loop; other site 643867000553 ATP binding site [chemical binding]; other site 643867000554 Q-loop/lid; other site 643867000555 ABC transporter signature motif; other site 643867000556 Walker B; other site 643867000557 D-loop; other site 643867000558 H-loop/switch region; other site 643867000559 ABC transporter; Region: ABC_tran_2; pfam12848 643867000560 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 643867000561 AAA ATPase domain; Region: AAA_16; pfam13191 643867000562 Mechanosensitive ion channel; Region: MS_channel; pfam00924 643867000563 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 643867000564 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867000565 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867000566 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867000567 ligand binding site [chemical binding]; other site 643867000568 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867000569 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867000570 ligand binding site [chemical binding]; other site 643867000571 PLD-like domain; Region: PLDc_2; pfam13091 643867000572 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 643867000573 putative homodimer interface [polypeptide binding]; other site 643867000574 putative active site [active] 643867000575 catalytic site [active] 643867000576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867000577 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 643867000578 Walker A motif; other site 643867000579 ATP binding site [chemical binding]; other site 643867000580 Walker B motif; other site 643867000581 arginine finger; other site 643867000582 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 643867000583 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 643867000584 active site 643867000585 catalytic triad [active] 643867000586 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 643867000587 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 643867000588 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 643867000589 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 643867000590 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 643867000591 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 643867000592 PQQ-like domain; Region: PQQ_2; pfam13360 643867000593 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 643867000594 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 643867000595 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 643867000596 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 643867000597 active site 643867000598 nucleophile elbow; other site 643867000599 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 643867000600 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 643867000601 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 643867000602 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 643867000603 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 643867000604 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 643867000605 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 643867000606 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 643867000607 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867000608 ligand binding site [chemical binding]; other site 643867000609 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 643867000610 active site 643867000611 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 643867000612 NMT1/THI5 like; Region: NMT1; pfam09084 643867000613 Transglycosylase; Region: Transgly; pfam00912 643867000614 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 643867000615 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 643867000616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000617 binding surface 643867000618 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000619 TPR motif; other site 643867000620 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000622 binding surface 643867000623 TPR motif; other site 643867000624 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000625 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 643867000626 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 643867000627 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 643867000628 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 643867000629 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 643867000630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 643867000631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 643867000632 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 643867000633 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 643867000634 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 643867000635 active site 643867000636 substrate-binding site [chemical binding]; other site 643867000637 metal-binding site [ion binding] 643867000638 ATP binding site [chemical binding]; other site 643867000639 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 643867000640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867000641 putative substrate translocation pore; other site 643867000642 POT family; Region: PTR2; cl17359 643867000643 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 643867000644 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 643867000645 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867000646 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 643867000647 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 643867000648 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867000649 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867000650 PKD domain; Region: PKD; pfam00801 643867000651 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867000652 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 643867000653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867000654 ATP binding site [chemical binding]; other site 643867000655 putative Mg++ binding site [ion binding]; other site 643867000656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867000657 nucleotide binding region [chemical binding]; other site 643867000658 ATP-binding site [chemical binding]; other site 643867000659 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 643867000660 TPR repeat; Region: TPR_11; pfam13414 643867000661 TPR repeat; Region: TPR_11; pfam13414 643867000662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000663 binding surface 643867000664 TPR motif; other site 643867000665 TPR repeat; Region: TPR_11; pfam13414 643867000666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000667 TPR motif; other site 643867000668 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 643867000669 Transcriptional regulators [Transcription]; Region: MarR; COG1846 643867000670 MarR family; Region: MarR; pfam01047 643867000671 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 643867000672 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 643867000673 Uncharacterized conserved protein [Function unknown]; Region: COG5276 643867000674 LVIVD repeat; Region: LVIVD; pfam08309 643867000675 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 643867000676 Predicted permeases [General function prediction only]; Region: COG0795 643867000677 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 643867000678 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 643867000679 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 643867000680 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 643867000681 16S/18S rRNA binding site [nucleotide binding]; other site 643867000682 S13e-L30e interaction site [polypeptide binding]; other site 643867000683 25S rRNA binding site [nucleotide binding]; other site 643867000684 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 643867000685 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 643867000686 RNase E interface [polypeptide binding]; other site 643867000687 trimer interface [polypeptide binding]; other site 643867000688 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 643867000689 RNase E interface [polypeptide binding]; other site 643867000690 trimer interface [polypeptide binding]; other site 643867000691 active site 643867000692 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 643867000693 putative nucleic acid binding region [nucleotide binding]; other site 643867000694 G-X-X-G motif; other site 643867000695 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 643867000696 RNA binding site [nucleotide binding]; other site 643867000697 domain interface; other site 643867000698 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 643867000699 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 643867000700 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867000701 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 643867000702 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867000703 DNA binding residues [nucleotide binding] 643867000704 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 643867000705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 643867000706 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 643867000707 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 643867000708 active site 643867000709 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 643867000710 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 643867000711 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 643867000712 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 643867000713 active site 643867000714 dinuclear metal binding site [ion binding]; other site 643867000715 dimerization interface [polypeptide binding]; other site 643867000716 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 643867000717 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 643867000718 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 643867000719 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 643867000720 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 643867000721 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 643867000722 Helix-turn-helix domain; Region: HTH_17; pfam12728 643867000723 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867000724 non-specific DNA binding site [nucleotide binding]; other site 643867000725 salt bridge; other site 643867000726 sequence-specific DNA binding site [nucleotide binding]; other site 643867000727 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 643867000728 HsdM N-terminal domain; Region: HsdM_N; pfam12161 643867000729 Methyltransferase domain; Region: Methyltransf_26; pfam13659 643867000730 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 643867000731 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 643867000732 Divergent AAA domain; Region: AAA_4; pfam04326 643867000733 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 643867000734 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 643867000735 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 643867000736 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 643867000737 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 643867000738 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 643867000739 FeS/SAM binding site; other site 643867000740 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 643867000741 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 643867000742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867000743 ATP binding site [chemical binding]; other site 643867000744 putative Mg++ binding site [ion binding]; other site 643867000745 fructoselysine 3-epimerase; Provisional; Region: PRK09856 643867000746 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 643867000747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867000748 non-specific DNA binding site [nucleotide binding]; other site 643867000749 salt bridge; other site 643867000750 sequence-specific DNA binding site [nucleotide binding]; other site 643867000751 HipA N-terminal domain; Region: Couple_hipA; pfam13657 643867000752 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 643867000753 HipA-like N-terminal domain; Region: HipA_N; pfam07805 643867000754 HipA-like C-terminal domain; Region: HipA_C; pfam07804 643867000755 periplasmic chaperone; Provisional; Region: PRK10780 643867000756 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 643867000757 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867000758 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 643867000759 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 643867000760 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 643867000761 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 643867000762 active site 643867000763 DNA binding site [nucleotide binding] 643867000764 Int/Topo IB signature motif; other site 643867000765 PQQ-like domain; Region: PQQ_2; pfam13360 643867000766 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867000767 PKD domain; Region: PKD; pfam00801 643867000768 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 643867000769 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 643867000770 Protein of unknown function (DUF418); Region: DUF418; cl12135 643867000771 Protein of unknown function (DUF418); Region: DUF418; pfam04235 643867000772 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 643867000773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867000774 active site 643867000775 phosphorylation site [posttranslational modification] 643867000776 intermolecular recognition site; other site 643867000777 dimerization interface [polypeptide binding]; other site 643867000778 LytTr DNA-binding domain; Region: LytTR; smart00850 643867000779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000780 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000781 binding surface 643867000782 TPR motif; other site 643867000783 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 643867000785 Histidine kinase; Region: HisKA_2; pfam07568 643867000786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000787 ATP binding site [chemical binding]; other site 643867000788 Mg2+ binding site [ion binding]; other site 643867000789 G-X-G motif; other site 643867000790 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 643867000791 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 643867000792 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 643867000793 Phenylacetic acid degradation B; Region: PaaB; cl01371 643867000794 Phenylacetic acid degradation B; Region: PaaB; cl01371 643867000795 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 643867000796 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 643867000797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867000798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 643867000799 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 643867000800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867000801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867000802 dimer interface [polypeptide binding]; other site 643867000803 phosphorylation site [posttranslational modification] 643867000804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000805 ATP binding site [chemical binding]; other site 643867000806 Mg2+ binding site [ion binding]; other site 643867000807 G-X-G motif; other site 643867000808 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000809 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000811 binding surface 643867000812 TPR motif; other site 643867000813 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000815 binding surface 643867000816 TPR motif; other site 643867000817 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867000818 CHAT domain; Region: CHAT; pfam12770 643867000819 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 643867000820 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 643867000821 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 643867000822 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 643867000823 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 643867000824 GAF domain; Region: GAF_3; pfam13492 643867000825 GAF domain; Region: GAF_2; pfam13185 643867000826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867000827 PAS domain; Region: PAS_9; pfam13426 643867000828 putative active site [active] 643867000829 heme pocket [chemical binding]; other site 643867000830 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 643867000831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867000832 S-adenosylmethionine binding site [chemical binding]; other site 643867000833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867000834 S-adenosylmethionine binding site [chemical binding]; other site 643867000835 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 643867000836 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 643867000837 ligand binding site [chemical binding]; other site 643867000838 active site 643867000839 UGI interface [polypeptide binding]; other site 643867000840 catalytic site [active] 643867000841 Leucine rich repeat; Region: LRR_8; pfam13855 643867000842 Leucine rich repeat; Region: LRR_8; pfam13855 643867000843 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 643867000844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000845 ATP binding site [chemical binding]; other site 643867000846 Mg2+ binding site [ion binding]; other site 643867000847 G-X-G motif; other site 643867000848 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 643867000849 anchoring element; other site 643867000850 dimer interface [polypeptide binding]; other site 643867000851 ATP binding site [chemical binding]; other site 643867000852 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 643867000853 active site 643867000854 putative metal-binding site [ion binding]; other site 643867000855 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 643867000856 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 643867000857 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 643867000858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867000859 homodimer interface [polypeptide binding]; other site 643867000860 catalytic residue [active] 643867000861 prephenate dehydrogenase; Validated; Region: PRK08507 643867000862 Prephenate dehydrogenase; Region: PDH; pfam02153 643867000863 Methyltransferase domain; Region: Methyltransf_23; pfam13489 643867000864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867000865 S-adenosylmethionine binding site [chemical binding]; other site 643867000866 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 643867000867 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 643867000868 Predicted transcriptional regulators [Transcription]; Region: COG1695 643867000869 Transcriptional regulator PadR-like family; Region: PadR; cl17335 643867000870 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867000871 polyphosphate kinase; Provisional; Region: PRK05443 643867000872 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 643867000873 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 643867000874 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 643867000875 putative active site [active] 643867000876 catalytic site [active] 643867000877 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 643867000878 putative domain interface [polypeptide binding]; other site 643867000879 putative active site [active] 643867000880 catalytic site [active] 643867000881 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 643867000882 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 643867000883 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867000884 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 643867000885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 643867000886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867000887 active site 643867000888 phosphorylation site [posttranslational modification] 643867000889 intermolecular recognition site; other site 643867000890 dimerization interface [polypeptide binding]; other site 643867000891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 643867000892 DNA binding residues [nucleotide binding] 643867000893 dimerization interface [polypeptide binding]; other site 643867000894 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 643867000895 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 643867000896 Histidine kinase; Region: HisKA_2; pfam07568 643867000897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867000898 ATP binding site [chemical binding]; other site 643867000899 Mg2+ binding site [ion binding]; other site 643867000900 G-X-G motif; other site 643867000901 membrane protein insertase; Provisional; Region: PRK01318 643867000902 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 643867000903 CTP synthetase; Validated; Region: pyrG; PRK05380 643867000904 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 643867000905 Catalytic site [active] 643867000906 active site 643867000907 UTP binding site [chemical binding]; other site 643867000908 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 643867000909 active site 643867000910 putative oxyanion hole; other site 643867000911 catalytic triad [active] 643867000912 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 643867000913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867000914 S-adenosylmethionine binding site [chemical binding]; other site 643867000915 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 643867000916 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867000917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867000918 DNA binding residues [nucleotide binding] 643867000919 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 643867000920 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 643867000921 active site 643867000922 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 643867000923 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 643867000924 Predicted permeases [General function prediction only]; Region: COG0795 643867000925 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 643867000926 EamA-like transporter family; Region: EamA; pfam00892 643867000927 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 643867000928 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 643867000929 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 643867000930 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 643867000931 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 643867000932 NAD binding site [chemical binding]; other site 643867000933 homotetramer interface [polypeptide binding]; other site 643867000934 homodimer interface [polypeptide binding]; other site 643867000935 substrate binding site [chemical binding]; other site 643867000936 active site 643867000937 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 643867000938 Mechanosensitive ion channel; Region: MS_channel; pfam00924 643867000939 Predicted dehydrogenase [General function prediction only]; Region: COG0579 643867000940 hydroxyglutarate oxidase; Provisional; Region: PRK11728 643867000941 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 643867000942 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 643867000943 active site 643867000944 HIGH motif; other site 643867000945 dimer interface [polypeptide binding]; other site 643867000946 KMSKS motif; other site 643867000947 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 643867000948 RNA binding surface [nucleotide binding]; other site 643867000949 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 643867000950 S1 domain; Region: S1_2; pfam13509 643867000951 S1 domain; Region: S1_2; pfam13509 643867000952 Flagellin N-methylase; Region: FliB; pfam03692 643867000953 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 643867000954 DNA polymerase III, delta subunit; Region: holA; TIGR01128 643867000955 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 643867000956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000957 binding surface 643867000958 TPR motif; other site 643867000959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000960 binding surface 643867000961 TPR motif; other site 643867000962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867000963 binding surface 643867000964 TPR motif; other site 643867000965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867000966 binding surface 643867000967 TPR motif; other site 643867000968 Sporulation related domain; Region: SPOR; pfam05036 643867000969 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 643867000970 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 643867000971 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 643867000972 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 643867000973 Putative methyltransferase; Region: Methyltransf_4; cl17290 643867000974 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 643867000975 active site 643867000976 Predicted deacylase [General function prediction only]; Region: COG3608 643867000977 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 643867000978 putative active site [active] 643867000979 Zn binding site [ion binding]; other site 643867000980 Bacterial sugar transferase; Region: Bac_transf; pfam02397 643867000981 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 643867000982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867000983 active site 643867000984 phosphorylation site [posttranslational modification] 643867000985 intermolecular recognition site; other site 643867000986 dimerization interface [polypeptide binding]; other site 643867000987 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 643867000988 DNA binding site [nucleotide binding] 643867000989 short chain dehydrogenase; Provisional; Region: PRK07326 643867000990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867000991 NAD(P) binding site [chemical binding]; other site 643867000992 active site 643867000993 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 643867000994 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 643867000995 MoxR-like ATPases [General function prediction only]; Region: COG0714 643867000996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867000997 Walker A motif; other site 643867000998 ATP binding site [chemical binding]; other site 643867000999 Walker B motif; other site 643867001000 arginine finger; other site 643867001001 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 643867001002 Protein of unknown function DUF58; Region: DUF58; pfam01882 643867001003 von Willebrand factor type A domain; Region: VWA_2; pfam13519 643867001004 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 643867001005 hypothetical protein; Provisional; Region: PRK08262 643867001006 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 643867001007 metal binding site [ion binding]; metal-binding site 643867001008 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 643867001009 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 643867001010 aspartate racemase; Region: asp_race; TIGR00035 643867001011 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 643867001012 hypothetical protein; Provisional; Region: PRK09256 643867001013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867001014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 643867001015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867001016 ATP binding site [chemical binding]; other site 643867001017 Mg2+ binding site [ion binding]; other site 643867001018 G-X-G motif; other site 643867001019 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 643867001020 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 643867001021 PhnA protein; Region: PhnA; pfam03831 643867001022 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 643867001023 metal binding site [ion binding]; metal-binding site 643867001024 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 643867001025 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 643867001026 active site 643867001027 HIGH motif; other site 643867001028 nucleotide binding site [chemical binding]; other site 643867001029 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 643867001030 active site 643867001031 KMSKS motif; other site 643867001032 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 643867001033 HYR domain; Region: HYR; pfam02494 643867001034 HYR domain; Region: HYR; pfam02494 643867001035 HYR domain; Region: HYR; pfam02494 643867001036 HYR domain; Region: HYR; pfam02494 643867001037 HYR domain; Region: HYR; pfam02494 643867001038 HYR domain; Region: HYR; pfam02494 643867001039 HYR domain; Region: HYR; pfam02494 643867001040 HYR domain; Region: HYR; pfam02494 643867001041 HYR domain; Region: HYR; pfam02494 643867001042 HYR domain; Region: HYR; pfam02494 643867001043 HYR domain; Region: HYR; pfam02494 643867001044 HYR domain; Region: HYR; pfam02494 643867001045 HYR domain; Region: HYR; pfam02494 643867001046 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867001047 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 643867001048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867001049 binding surface 643867001050 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 643867001051 TPR motif; other site 643867001052 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867001053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867001054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 643867001055 dimer interface [polypeptide binding]; other site 643867001056 phosphorylation site [posttranslational modification] 643867001057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867001058 ATP binding site [chemical binding]; other site 643867001059 Mg2+ binding site [ion binding]; other site 643867001060 G-X-G motif; other site 643867001061 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 643867001062 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 643867001063 glycerol-3-phosphate dehydrogenase; Provisional; Region: PTZ00345 643867001064 VPS10 domain; Region: VPS10; smart00602 643867001065 VPS10 domain; Region: VPS10; smart00602 643867001066 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 643867001067 Fasciclin domain; Region: Fasciclin; pfam02469 643867001068 DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135 643867001069 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 643867001070 active site 643867001071 PHP Thumb interface [polypeptide binding]; other site 643867001072 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 643867001073 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 643867001074 active site 643867001075 DNA binding site [nucleotide binding] 643867001076 Ecdysteroid kinase; Region: EcKinase; cl17738 643867001077 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 643867001078 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 643867001079 active site 643867001080 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 643867001081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867001082 NAD(P) binding site [chemical binding]; other site 643867001083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867001084 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 643867001085 active site 643867001086 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 643867001087 RNA/DNA hybrid binding site [nucleotide binding]; other site 643867001088 active site 643867001089 Amidohydrolase; Region: Amidohydro_2; pfam04909 643867001090 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 643867001091 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867001092 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867001093 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867001094 ligand binding site [chemical binding]; other site 643867001095 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 643867001096 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 643867001097 cofactor binding site; other site 643867001098 DNA binding site [nucleotide binding] 643867001099 substrate interaction site [chemical binding]; other site 643867001100 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 643867001101 substrate interaction site [chemical binding]; other site 643867001102 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 643867001103 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 643867001104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867001105 ATP binding site [chemical binding]; other site 643867001106 putative Mg++ binding site [ion binding]; other site 643867001107 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 643867001108 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 643867001109 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 643867001110 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 643867001111 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 643867001112 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 643867001113 putative NAD(P) binding site [chemical binding]; other site 643867001114 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 643867001115 Transglycosylase; Region: Transgly; pfam00912 643867001116 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 643867001117 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 643867001118 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 643867001119 putative active site [active] 643867001120 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 643867001121 MG2 domain; Region: A2M_N; pfam01835 643867001122 Alpha-2-macroglobulin family; Region: A2M; pfam00207 643867001123 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 643867001124 surface patch; other site 643867001125 thioester region; other site 643867001126 specificity defining residues; other site 643867001127 Membrane protein of unknown function; Region: DUF360; pfam04020 643867001128 carboxy-terminal protease; Provisional; Region: PRK11186 643867001129 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 643867001130 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 643867001131 protein binding site [polypeptide binding]; other site 643867001132 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 643867001133 Catalytic dyad [active] 643867001134 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 643867001135 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 643867001136 Beta-lactamase; Region: Beta-lactamase; pfam00144 643867001137 lycopene cyclase; Region: lycopene_cycl; TIGR01789 643867001138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867001139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867001140 dimer interface [polypeptide binding]; other site 643867001141 phosphorylation site [posttranslational modification] 643867001142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867001143 ATP binding site [chemical binding]; other site 643867001144 Mg2+ binding site [ion binding]; other site 643867001145 G-X-G motif; other site 643867001146 signal recognition particle protein; Provisional; Region: PRK10867 643867001147 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 643867001148 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 643867001149 P loop; other site 643867001150 GTP binding site [chemical binding]; other site 643867001151 Signal peptide binding domain; Region: SRP_SPB; pfam02978 643867001152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867001153 binding surface 643867001154 TPR repeat; Region: TPR_11; pfam13414 643867001155 TPR motif; other site 643867001156 Tetratricopeptide repeat; Region: TPR_16; pfam13432 643867001157 TPR repeat; Region: TPR_11; pfam13414 643867001158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867001159 TPR motif; other site 643867001160 binding surface 643867001161 TPR repeat; Region: TPR_11; pfam13414 643867001162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867001163 binding surface 643867001164 TPR motif; other site 643867001165 TPR repeat; Region: TPR_11; pfam13414 643867001166 TPR repeat; Region: TPR_11; pfam13414 643867001167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867001168 binding surface 643867001169 TPR motif; other site 643867001170 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867001171 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867001172 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867001173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867001174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867001175 dimer interface [polypeptide binding]; other site 643867001176 phosphorylation site [posttranslational modification] 643867001177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 643867001178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867001179 active site 643867001180 phosphorylation site [posttranslational modification] 643867001181 intermolecular recognition site; other site 643867001182 dimerization interface [polypeptide binding]; other site 643867001183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 643867001184 DNA binding site [nucleotide binding] 643867001185 PAS fold; Region: PAS_3; pfam08447 643867001186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867001187 putative active site [active] 643867001188 heme pocket [chemical binding]; other site 643867001189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867001190 PAS fold; Region: PAS_3; pfam08447 643867001191 putative active site [active] 643867001192 heme pocket [chemical binding]; other site 643867001193 PAS domain; Region: PAS; smart00091 643867001194 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 643867001195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867001196 dimer interface [polypeptide binding]; other site 643867001197 phosphorylation site [posttranslational modification] 643867001198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867001199 ATP binding site [chemical binding]; other site 643867001200 Mg2+ binding site [ion binding]; other site 643867001201 G-X-G motif; other site 643867001202 Response regulator receiver domain; Region: Response_reg; pfam00072 643867001203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867001204 active site 643867001205 phosphorylation site [posttranslational modification] 643867001206 intermolecular recognition site; other site 643867001207 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 643867001208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867001209 active site 643867001210 phosphorylation site [posttranslational modification] 643867001211 intermolecular recognition site; other site 643867001212 dimerization interface [polypeptide binding]; other site 643867001213 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 643867001214 metal ion-dependent adhesion site (MIDAS); other site 643867001215 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 643867001216 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 643867001217 metal ion-dependent adhesion site (MIDAS); other site 643867001218 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 643867001219 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 643867001220 MutS domain III; Region: MutS_III; pfam05192 643867001221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867001222 Walker A/P-loop; other site 643867001223 ATP binding site [chemical binding]; other site 643867001224 Q-loop/lid; other site 643867001225 ABC transporter signature motif; other site 643867001226 Walker B; other site 643867001227 D-loop; other site 643867001228 H-loop/switch region; other site 643867001229 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 643867001230 Smr domain; Region: Smr; pfam01713 643867001231 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 643867001232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867001233 active site 643867001234 phosphorylation site [posttranslational modification] 643867001235 intermolecular recognition site; other site 643867001236 dimerization interface [polypeptide binding]; other site 643867001237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 643867001238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867001239 ATP binding site [chemical binding]; other site 643867001240 Mg2+ binding site [ion binding]; other site 643867001241 G-X-G motif; other site 643867001242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867001243 PAS domain; Region: PAS_9; pfam13426 643867001244 putative active site [active] 643867001245 heme pocket [chemical binding]; other site 643867001246 GAF domain; Region: GAF_3; pfam13492 643867001247 GAF domain; Region: GAF_2; pfam13185 643867001248 PAS domain S-box; Region: sensory_box; TIGR00229 643867001249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867001250 putative active site [active] 643867001251 heme pocket [chemical binding]; other site 643867001252 PAS domain; Region: PAS_9; pfam13426 643867001253 PAS domain S-box; Region: sensory_box; TIGR00229 643867001254 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867001255 putative active site [active] 643867001256 heme pocket [chemical binding]; other site 643867001257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867001258 PAS fold; Region: PAS_3; pfam08447 643867001259 putative active site [active] 643867001260 heme pocket [chemical binding]; other site 643867001261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867001262 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 643867001263 putative active site [active] 643867001264 heme pocket [chemical binding]; other site 643867001265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867001266 putative active site [active] 643867001267 heme pocket [chemical binding]; other site 643867001268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867001269 dimer interface [polypeptide binding]; other site 643867001270 phosphorylation site [posttranslational modification] 643867001271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867001272 ATP binding site [chemical binding]; other site 643867001273 Mg2+ binding site [ion binding]; other site 643867001274 G-X-G motif; other site 643867001275 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 643867001276 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 643867001277 ligand binding surface [chemical binding]; other site 643867001278 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001279 Ca2+ binding site [ion binding]; other site 643867001280 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001281 Ca2+ binding site [ion binding]; other site 643867001282 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001283 Ca2+ binding site [ion binding]; other site 643867001284 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001285 Ca2+ binding site [ion binding]; other site 643867001286 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001287 Ca2+ binding site [ion binding]; other site 643867001288 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001289 Ca2+ binding site [ion binding]; other site 643867001290 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001291 Ca2+ binding site [ion binding]; other site 643867001292 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001293 Ca2+ binding site [ion binding]; other site 643867001294 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001295 Ca2+ binding site [ion binding]; other site 643867001296 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001297 Ca2+ binding site [ion binding]; other site 643867001298 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001299 Ca2+ binding site [ion binding]; other site 643867001300 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001301 Ca2+ binding site [ion binding]; other site 643867001302 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867001303 Ca2+ binding site [ion binding]; other site 643867001304 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867001305 potential frameshift: common BLAST hit: gi|258514802|ref|YP_003191024.1| transcriptional regulator 643867001306 Divergent AAA domain; Region: AAA_4; pfam04326 643867001307 potential frameshift: common BLAST hit: gi|150389397|ref|YP_001319446.1| transcriptional regulator 643867001308 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 643867001309 UPF0489 domain; Region: UPF0489; pfam12640 643867001310 Endonuclease I; Region: Endonuclease_1; pfam04231 643867001311 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867001312 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 643867001313 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 643867001314 cofactor binding site; other site 643867001315 DNA binding site [nucleotide binding] 643867001316 substrate interaction site [chemical binding]; other site 643867001317 HpaII restriction endonuclease; Region: RE_HpaII; pfam09561 643867001318 Restriction endonuclease; Region: Mrr_cat; pfam04471 643867001319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867001320 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 643867001321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 643867001322 Walker A/P-loop; other site 643867001323 ATP binding site [chemical binding]; other site 643867001324 Helix-turn-helix domain; Region: HTH_17; pfam12728 643867001325 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 643867001326 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 643867001327 Int/Topo IB signature motif; other site 643867001328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 643867001329 MoxR-like ATPases [General function prediction only]; Region: COG0714 643867001330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867001331 Walker A motif; other site 643867001332 ATP binding site [chemical binding]; other site 643867001333 Walker B motif; other site 643867001334 arginine finger; other site 643867001335 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 643867001336 MASE1; Region: MASE1; pfam05231 643867001337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867001338 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 643867001339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867001340 dimer interface [polypeptide binding]; other site 643867001341 phosphorylation site [posttranslational modification] 643867001342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867001343 ATP binding site [chemical binding]; other site 643867001344 Mg2+ binding site [ion binding]; other site 643867001345 G-X-G motif; other site 643867001346 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 643867001347 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 643867001348 Peptidase family M23; Region: Peptidase_M23; pfam01551 643867001349 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 643867001350 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 643867001351 active site 643867001352 metal binding site [ion binding]; metal-binding site 643867001353 Penicillinase repressor; Region: Pencillinase_R; pfam03965 643867001354 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867001355 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 643867001356 E3 interaction surface; other site 643867001357 lipoyl attachment site [posttranslational modification]; other site 643867001358 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 643867001359 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 643867001360 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 643867001361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867001362 active site 643867001363 phosphorylation site [posttranslational modification] 643867001364 intermolecular recognition site; other site 643867001365 dimerization interface [polypeptide binding]; other site 643867001366 LytTr DNA-binding domain; Region: LytTR; smart00850 643867001367 Histidine kinase; Region: His_kinase; pfam06580 643867001368 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 643867001369 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 643867001370 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867001371 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867001372 Amidohydrolase; Region: Amidohydro_4; pfam13147 643867001373 active site 643867001374 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 643867001375 Beta-lactamase; Region: Beta-lactamase; pfam00144 643867001376 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 643867001377 catalytic motif [active] 643867001378 Catalytic residue [active] 643867001379 LytTr DNA-binding domain; Region: LytTR; pfam04397 643867001380 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 643867001381 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 643867001382 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 643867001383 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 643867001384 active site 643867001385 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 643867001386 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 643867001387 Peptidase family M23; Region: Peptidase_M23; pfam01551 643867001388 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 643867001389 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 643867001390 putative NAD(P) binding site [chemical binding]; other site 643867001391 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 643867001392 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 643867001393 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 643867001394 RNA methyltransferase, RsmE family; Region: TIGR00046 643867001395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867001396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867001397 dimer interface [polypeptide binding]; other site 643867001398 phosphorylation site [posttranslational modification] 643867001399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867001400 ATP binding site [chemical binding]; other site 643867001401 Mg2+ binding site [ion binding]; other site 643867001402 G-X-G motif; other site 643867001403 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 643867001404 active site 643867001405 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 643867001406 phosphate binding site [ion binding]; other site 643867001407 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 643867001408 MarR family; Region: MarR; pfam01047 643867001409 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 643867001410 catalytic residues [active] 643867001411 dimer interface [polypeptide binding]; other site 643867001412 Predicted membrane protein [Function unknown]; Region: COG4270 643867001413 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 643867001414 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 643867001415 active site 643867001416 Ca binding site [ion binding]; other site 643867001417 catalytic site [active] 643867001418 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 643867001419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867001420 Response regulator receiver domain; Region: Response_reg; pfam00072 643867001421 active site 643867001422 phosphorylation site [posttranslational modification] 643867001423 intermolecular recognition site; other site 643867001424 dimerization interface [polypeptide binding]; other site 643867001425 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 643867001426 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 643867001427 putative NAD(P) binding site [chemical binding]; other site 643867001428 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 643867001429 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 643867001430 Ligand Binding Site [chemical binding]; other site 643867001431 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 643867001432 putative catalytic residues [active] 643867001433 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 643867001434 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 643867001435 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 643867001436 putative active site [active] 643867001437 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 643867001438 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 643867001439 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 643867001440 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 643867001441 ArsC family; Region: ArsC; pfam03960 643867001442 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 643867001443 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867001444 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867001445 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 643867001446 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 643867001447 substrate binding site [chemical binding]; other site 643867001448 hexamer interface [polypeptide binding]; other site 643867001449 metal binding site [ion binding]; metal-binding site 643867001450 fructokinase; Reviewed; Region: PRK09557 643867001451 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 643867001452 nucleotide binding site [chemical binding]; other site 643867001453 helicase 45; Provisional; Region: PTZ00424 643867001454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 643867001455 ATP binding site [chemical binding]; other site 643867001456 putative Mg++ binding site [ion binding]; other site 643867001457 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867001458 nucleotide binding region [chemical binding]; other site 643867001459 ATP-binding site [chemical binding]; other site 643867001460 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 643867001461 DEAD-like helicases superfamily; Region: DEXDc; smart00487 643867001462 ATP binding site [chemical binding]; other site 643867001463 Mg++ binding site [ion binding]; other site 643867001464 motif III; other site 643867001465 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867001466 nucleotide binding region [chemical binding]; other site 643867001467 ATP-binding site [chemical binding]; other site 643867001468 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 643867001469 PAS fold; Region: PAS_4; pfam08448 643867001470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867001471 putative active site [active] 643867001472 heme pocket [chemical binding]; other site 643867001473 PAS domain; Region: PAS; smart00091 643867001474 PAS domain; Region: PAS_9; pfam13426 643867001475 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 643867001476 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 643867001477 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 643867001478 active site 643867001479 DNA polymerase IV; Validated; Region: PRK02406 643867001480 DNA binding site [nucleotide binding] 643867001481 Caspase domain; Region: Peptidase_C14; pfam00656 643867001482 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 643867001483 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 643867001484 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 643867001485 starch binding site [chemical binding]; other site 643867001486 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 643867001487 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 643867001488 Family description; Region: VCBS; pfam13517 643867001489 Family description; Region: VCBS; pfam13517 643867001490 Family description; Region: VCBS; pfam13517 643867001491 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 643867001492 Interdomain contacts; other site 643867001493 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867001494 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 643867001495 methionine sulfoxide reductase A; Provisional; Region: PRK14054 643867001496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867001497 binding surface 643867001498 TPR motif; other site 643867001499 Tetratricopeptide repeat; Region: TPR_16; pfam13432 643867001500 DNA gyrase subunit A; Validated; Region: PRK05560 643867001501 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 643867001502 CAP-like domain; other site 643867001503 active site 643867001504 primary dimer interface [polypeptide binding]; other site 643867001505 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 643867001506 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 643867001507 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 643867001508 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 643867001509 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 643867001510 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 643867001511 dimer interface [polypeptide binding]; other site 643867001512 active site 643867001513 metal binding site [ion binding]; metal-binding site 643867001514 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 643867001515 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 643867001516 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 643867001517 23S rRNA binding site [nucleotide binding]; other site 643867001518 L21 binding site [polypeptide binding]; other site 643867001519 L13 binding site [polypeptide binding]; other site 643867001520 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 643867001521 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 643867001522 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 643867001523 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 643867001524 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 643867001525 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 643867001526 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 643867001527 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 643867001528 active site 643867001529 dimer interface [polypeptide binding]; other site 643867001530 motif 1; other site 643867001531 motif 2; other site 643867001532 motif 3; other site 643867001533 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 643867001534 anticodon binding site; other site 643867001535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 643867001536 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 643867001537 active site 643867001538 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 643867001539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 643867001540 putative DNA binding site [nucleotide binding]; other site 643867001541 putative Zn2+ binding site [ion binding]; other site 643867001542 AsnC family; Region: AsnC_trans_reg; pfam01037 643867001543 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 643867001544 acyl-activating enzyme (AAE) consensus motif; other site 643867001545 AMP binding site [chemical binding]; other site 643867001546 active site 643867001547 CoA binding site [chemical binding]; other site 643867001548 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 643867001549 PGAP1-like protein; Region: PGAP1; pfam07819 643867001550 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 643867001551 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 643867001552 hypothetical protein; Provisional; Region: PRK13665 643867001553 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 643867001554 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 643867001555 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 643867001556 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 643867001557 NAD-dependent deacetylase; Provisional; Region: PRK00481 643867001558 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 643867001559 NAD+ binding site [chemical binding]; other site 643867001560 substrate binding site [chemical binding]; other site 643867001561 Zn binding site [ion binding]; other site 643867001562 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 643867001563 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 643867001564 E3 interaction surface; other site 643867001565 lipoyl attachment site [posttranslational modification]; other site 643867001566 e3 binding domain; Region: E3_binding; pfam02817 643867001567 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 643867001568 competence damage-inducible protein A; Provisional; Region: PRK00549 643867001569 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 643867001570 putative MPT binding site; other site 643867001571 Competence-damaged protein; Region: CinA; pfam02464 643867001572 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 643867001573 active site 643867001574 catalytic residues [active] 643867001575 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 643867001576 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867001577 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 643867001578 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 643867001579 NAD(P) binding site [chemical binding]; other site 643867001580 catalytic residues [active] 643867001581 Response regulator receiver domain; Region: Response_reg; pfam00072 643867001582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867001583 active site 643867001584 phosphorylation site [posttranslational modification] 643867001585 intermolecular recognition site; other site 643867001586 dimerization interface [polypeptide binding]; other site 643867001587 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 643867001588 Mechanosensitive ion channel; Region: MS_channel; pfam00924 643867001589 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 643867001590 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 643867001591 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 643867001592 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 643867001593 ABC transporter; Region: ABC_tran_2; pfam12848 643867001594 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 643867001595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867001596 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 643867001597 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 643867001598 RHS Repeat; Region: RHS_repeat; pfam05593 643867001599 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 643867001600 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 643867001601 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 643867001602 putative active site [active] 643867001603 putative metal binding site [ion binding]; other site 643867001604 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 643867001605 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 643867001606 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 643867001607 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 643867001608 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867001609 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 643867001610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867001611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 643867001612 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 643867001613 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 643867001614 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 643867001615 dimerization interface [polypeptide binding]; other site 643867001616 ATP binding site [chemical binding]; other site 643867001617 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 643867001618 dimerization interface [polypeptide binding]; other site 643867001619 ATP binding site [chemical binding]; other site 643867001620 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 643867001621 putative active site [active] 643867001622 catalytic triad [active] 643867001623 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 643867001624 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 643867001625 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 643867001626 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 643867001627 active site 643867001628 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 643867001629 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 643867001630 5S rRNA interface [nucleotide binding]; other site 643867001631 CTC domain interface [polypeptide binding]; other site 643867001632 L16 interface [polypeptide binding]; other site 643867001633 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 643867001634 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 643867001635 RNA binding surface [nucleotide binding]; other site 643867001636 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 643867001637 probable active site [active] 643867001638 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 643867001639 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 643867001640 putative active site [active] 643867001641 catalytic residue [active] 643867001642 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 643867001643 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 643867001644 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 643867001645 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 643867001646 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 643867001647 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 643867001648 Zn binding site [ion binding]; other site 643867001649 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 643867001650 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 643867001651 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 643867001652 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 643867001653 Transposase; Region: DEDD_Tnp_IS110; pfam01548 643867001654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 643867001655 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 643867001656 GxxExxY protein; Region: GxxExxY; TIGR04256 643867001657 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 643867001658 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 643867001659 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 643867001660 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 643867001661 putative trimer interface [polypeptide binding]; other site 643867001662 putative CoA binding site [chemical binding]; other site 643867001663 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 643867001664 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 643867001665 putative trimer interface [polypeptide binding]; other site 643867001666 putative CoA binding site [chemical binding]; other site 643867001667 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 643867001668 catalytic residues [active] 643867001669 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 643867001670 Zn binding site [ion binding]; other site 643867001671 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 643867001672 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 643867001673 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 643867001674 hinge; other site 643867001675 active site 643867001676 tRNA-specific 2-thiouridylase MnmA; Reviewed; Region: mnmA; PRK00143 643867001677 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 643867001678 Interdomain contacts; other site 643867001679 Cytokine receptor motif; other site 643867001680 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 643867001681 oligomeric interface; other site 643867001682 putative active site [active] 643867001683 homodimer interface [polypeptide binding]; other site 643867001684 Methyltransferase domain; Region: Methyltransf_24; pfam13578 643867001685 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 643867001686 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 643867001687 putative trimer interface [polypeptide binding]; other site 643867001688 putative CoA binding site [chemical binding]; other site 643867001689 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 643867001690 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867001691 putative ADP-binding pocket [chemical binding]; other site 643867001692 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867001693 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 643867001694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867001695 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 643867001696 putative ADP-binding pocket [chemical binding]; other site 643867001697 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 643867001698 Methyltransferase domain; Region: Methyltransf_24; pfam13578 643867001699 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 643867001700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867001701 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 643867001702 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867001703 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 643867001704 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 643867001705 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 643867001706 active site 643867001707 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 643867001708 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 643867001709 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 643867001710 active site 643867001711 hypothetical protein; Provisional; Region: PRK07579 643867001712 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 643867001713 active site 643867001714 substrate binding site [chemical binding]; other site 643867001715 cosubstrate binding site; other site 643867001716 catalytic site [active] 643867001717 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 643867001718 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 643867001719 inhibitor-cofactor binding pocket; inhibition site 643867001720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867001721 catalytic residue [active] 643867001722 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 643867001723 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 643867001724 Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171 643867001725 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 643867001726 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 643867001727 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 643867001728 putative NAD(P) binding site [chemical binding]; other site 643867001729 active site 643867001730 putative substrate binding site [chemical binding]; other site 643867001731 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 643867001732 tyrosine kinase; Provisional; Region: PRK11519 643867001733 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 643867001734 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 643867001735 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 643867001736 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 643867001737 putative transposase OrfB; Reviewed; Region: PHA02517 643867001738 Integrase core domain; Region: rve; pfam00665 643867001739 Integrase core domain; Region: rve_3; pfam13683 643867001740 Transposase; Region: HTH_Tnp_1; pfam01527 643867001741 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 643867001742 active site residue [active] 643867001743 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 643867001744 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 643867001745 NAD(P) binding site [chemical binding]; other site 643867001746 catalytic residues [active] 643867001747 MFS/sugar transport protein; Region: MFS_2; pfam13347 643867001748 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 643867001749 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867001750 active site 643867001751 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867001752 Amidohydrolase; Region: Amidohydro_4; pfam13147 643867001753 active site 643867001754 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 643867001755 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 643867001756 active site 643867001757 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 643867001758 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 643867001759 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 643867001760 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 643867001761 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 643867001762 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 643867001763 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 643867001764 active site 643867001765 homodimer interface [polypeptide binding]; other site 643867001766 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 643867001767 active site 643867001768 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 643867001769 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 643867001770 active site 643867001771 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 643867001772 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 643867001773 NodB motif; other site 643867001774 active site 643867001775 catalytic site [active] 643867001776 metal binding site [ion binding]; metal-binding site 643867001777 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 643867001778 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 643867001779 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 643867001780 active site 643867001781 hypothetical protein; Provisional; Region: PRK02237 643867001782 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 643867001783 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 643867001784 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 643867001785 active site 643867001786 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 643867001787 Predicted membrane protein [Function unknown]; Region: COG4270 643867001788 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 643867001789 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 643867001790 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 643867001791 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867001792 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867001793 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867001794 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 643867001795 putative active site [active] 643867001796 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 643867001797 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 643867001798 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 643867001799 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 643867001800 CAP-like domain; other site 643867001801 active site 643867001802 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 643867001803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867001804 ATP binding site [chemical binding]; other site 643867001805 Mg2+ binding site [ion binding]; other site 643867001806 G-X-G motif; other site 643867001807 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 643867001808 ATP binding site [chemical binding]; other site 643867001809 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 643867001810 active site 643867001811 putative metal-binding site [ion binding]; other site 643867001812 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 643867001813 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 643867001814 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 643867001815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 643867001816 dimerization interface [polypeptide binding]; other site 643867001817 GAF domain; Region: GAF_3; pfam13492 643867001818 GAF domain; Region: GAF_2; pfam13185 643867001819 PAS fold; Region: PAS_4; pfam08448 643867001820 PAS domain; Region: PAS_9; pfam13426 643867001821 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 643867001822 putative active site [active] 643867001823 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 643867001824 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 643867001825 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 643867001826 alanine racemase; Reviewed; Region: alr; PRK00053 643867001827 active site 643867001828 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 643867001829 dimer interface [polypeptide binding]; other site 643867001830 substrate binding site [chemical binding]; other site 643867001831 catalytic residues [active] 643867001832 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 643867001833 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 643867001834 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 643867001835 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 643867001836 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 643867001837 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 643867001838 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 643867001839 RNA binding site [nucleotide binding]; other site 643867001840 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 643867001841 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 643867001842 active site 643867001843 HIGH motif; other site 643867001844 dimer interface [polypeptide binding]; other site 643867001845 KMSKS motif; other site 643867001846 Predicted membrane protein [Function unknown]; Region: COG2259 643867001847 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 643867001848 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 643867001849 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867001850 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867001851 Amidohydrolase; Region: Amidohydro_4; pfam13147 643867001852 active site 643867001853 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 643867001854 Na2 binding site [ion binding]; other site 643867001855 putative substrate binding site 1 [chemical binding]; other site 643867001856 Na binding site 1 [ion binding]; other site 643867001857 putative substrate binding site 2 [chemical binding]; other site 643867001858 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 643867001859 Sodium Bile acid symporter family; Region: SBF; pfam01758 643867001860 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 643867001861 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867001862 catalytic residues [active] 643867001863 Predicted transcriptional regulators [Transcription]; Region: COG1695 643867001864 Transcriptional regulator PadR-like family; Region: PadR; cl17335 643867001865 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 643867001866 active site 643867001867 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 643867001868 GTP cyclohydrolase I; Provisional; Region: PLN03044 643867001869 active site 643867001870 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 643867001871 classical (c) SDRs; Region: SDR_c; cd05233 643867001872 NAD(P) binding site [chemical binding]; other site 643867001873 active site 643867001874 HflC protein; Region: hflC; TIGR01932 643867001875 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 643867001876 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 643867001877 HflK protein; Region: hflK; TIGR01933 643867001878 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 643867001879 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 643867001880 PA/protease or protease-like domain interface [polypeptide binding]; other site 643867001881 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 643867001882 Peptidase family M28; Region: Peptidase_M28; pfam04389 643867001883 metal binding site [ion binding]; metal-binding site 643867001884 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 643867001885 nucleoside/Zn binding site; other site 643867001886 dimer interface [polypeptide binding]; other site 643867001887 catalytic motif [active] 643867001888 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 643867001889 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 643867001890 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 643867001891 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 643867001892 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 643867001893 GIY-YIG motif/motif A; other site 643867001894 putative active site [active] 643867001895 putative metal binding site [ion binding]; other site 643867001896 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 643867001897 GIY-YIG motif/motif A; other site 643867001898 putative active site [active] 643867001899 putative metal binding site [ion binding]; other site 643867001900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867001901 binding surface 643867001902 TPR repeat; Region: TPR_11; pfam13414 643867001903 TPR motif; other site 643867001904 TPR repeat; Region: TPR_11; pfam13414 643867001905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867001906 binding surface 643867001907 TPR repeat; Region: TPR_11; pfam13414 643867001908 TPR motif; other site 643867001909 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 643867001910 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 643867001911 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 643867001912 trimer interface [polypeptide binding]; other site 643867001913 active site 643867001914 substrate binding site [chemical binding]; other site 643867001915 CoA binding site [chemical binding]; other site 643867001916 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 643867001917 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867001918 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 643867001919 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 643867001920 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 643867001921 FeoA domain; Region: FeoA; pfam04023 643867001922 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 643867001923 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 643867001924 intersubunit interface [polypeptide binding]; other site 643867001925 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 643867001926 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 643867001927 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 643867001928 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 643867001929 ABC-ATPase subunit interface; other site 643867001930 dimer interface [polypeptide binding]; other site 643867001931 putative PBP binding regions; other site 643867001932 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 643867001933 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 643867001934 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 643867001935 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 643867001936 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 643867001937 ABC-ATPase subunit interface; other site 643867001938 dimer interface [polypeptide binding]; other site 643867001939 putative PBP binding regions; other site 643867001940 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 643867001941 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 643867001942 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 643867001943 active site 643867001944 FMN binding site [chemical binding]; other site 643867001945 2,4-decadienoyl-CoA binding site; other site 643867001946 catalytic residue [active] 643867001947 4Fe-4S cluster binding site [ion binding]; other site 643867001948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 643867001949 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 643867001950 DinB superfamily; Region: DinB_2; pfam12867 643867001951 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 643867001952 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 643867001953 active site 643867001954 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 643867001955 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 643867001956 Mechanosensitive ion channel; Region: MS_channel; pfam00924 643867001957 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 643867001958 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 643867001959 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 643867001960 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 643867001961 ligand binding site [chemical binding]; other site 643867001962 NAD binding site [chemical binding]; other site 643867001963 tetramer interface [polypeptide binding]; other site 643867001964 catalytic site [active] 643867001965 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 643867001966 L-serine binding site [chemical binding]; other site 643867001967 ACT domain interface; other site 643867001968 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867001969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867001970 binding surface 643867001971 TPR motif; other site 643867001972 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867001973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867001974 binding surface 643867001975 TPR motif; other site 643867001976 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867001977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867001978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867001979 dimer interface [polypeptide binding]; other site 643867001980 phosphorylation site [posttranslational modification] 643867001981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867001982 ATP binding site [chemical binding]; other site 643867001983 Mg2+ binding site [ion binding]; other site 643867001984 G-X-G motif; other site 643867001985 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 643867001986 TraB family; Region: TraB; cl12050 643867001987 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867001988 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 643867001989 ligand binding site [chemical binding]; other site 643867001990 flexible hinge region; other site 643867001991 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867001992 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 643867001993 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867001994 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 643867001995 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 643867001996 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 643867001997 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 643867001998 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 643867001999 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 643867002000 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 643867002001 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 643867002002 Helix-turn-helix domain; Region: HTH_18; pfam12833 643867002003 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 643867002004 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 643867002005 CoA-ligase; Region: Ligase_CoA; pfam00549 643867002006 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 643867002007 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 643867002008 Walker A/P-loop; other site 643867002009 ATP binding site [chemical binding]; other site 643867002010 Q-loop/lid; other site 643867002011 ABC transporter signature motif; other site 643867002012 Walker B; other site 643867002013 D-loop; other site 643867002014 H-loop/switch region; other site 643867002015 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 643867002016 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 643867002017 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 643867002018 dimer interface [polypeptide binding]; other site 643867002019 active site 643867002020 thymidylate synthase; Reviewed; Region: thyA; PRK01827 643867002021 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 643867002022 dimerization interface [polypeptide binding]; other site 643867002023 active site 643867002024 large tegument protein UL36; Provisional; Region: PHA03246 643867002025 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 643867002026 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 643867002027 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 643867002028 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 643867002029 catalytic residue [active] 643867002030 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 643867002031 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 643867002032 metal binding site [ion binding]; metal-binding site 643867002033 putative dimer interface [polypeptide binding]; other site 643867002034 hypothetical protein; Validated; Region: PRK02101 643867002035 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 643867002036 active site 643867002037 trehalose synthase; Region: treS_nterm; TIGR02456 643867002038 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 643867002039 Ca binding site [ion binding]; other site 643867002040 active site 643867002041 catalytic site [active] 643867002042 PIN domain; Region: PIN; pfam01850 643867002043 putative active site [active] 643867002044 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 643867002045 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 643867002046 active site 643867002047 intersubunit interface [polypeptide binding]; other site 643867002048 zinc binding site [ion binding]; other site 643867002049 Na+ binding site [ion binding]; other site 643867002050 starch binding outer membrane protein SusD; Region: SusD; cd08977 643867002051 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 643867002052 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867002053 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 643867002054 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 643867002055 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 643867002056 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 643867002057 active site 643867002058 catalytic site [active] 643867002059 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867002060 Transcriptional regulators [Transcription]; Region: PurR; COG1609 643867002061 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 643867002062 DNA binding site [nucleotide binding] 643867002063 domain linker motif; other site 643867002064 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 643867002065 dimerization interface [polypeptide binding]; other site 643867002066 ligand binding site [chemical binding]; other site 643867002067 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 643867002068 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 643867002069 putative active site [active] 643867002070 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 643867002071 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 643867002072 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 643867002073 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 643867002074 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 643867002075 trimer interface [polypeptide binding]; other site 643867002076 active site 643867002077 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 643867002078 catalytic site [active] 643867002079 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 643867002080 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 643867002081 active site 643867002082 catalytic site [active] 643867002083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867002084 Major Facilitator Superfamily; Region: MFS_1; pfam07690 643867002085 putative substrate translocation pore; other site 643867002086 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 643867002087 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 643867002088 Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935 643867002089 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 643867002090 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 643867002091 Interdomain contacts; other site 643867002092 Cytokine receptor motif; other site 643867002093 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 643867002094 Interdomain contacts; other site 643867002095 Cytokine receptor motif; other site 643867002096 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867002097 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 643867002098 active site 643867002099 HslU subunit interaction site [polypeptide binding]; other site 643867002100 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 643867002101 E3 interaction surface; other site 643867002102 lipoyl attachment site [posttranslational modification]; other site 643867002103 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 643867002104 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 643867002105 E3 interaction surface; other site 643867002106 lipoyl attachment site [posttranslational modification]; other site 643867002107 e3 binding domain; Region: E3_binding; pfam02817 643867002108 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 643867002109 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 643867002110 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 643867002111 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 643867002112 putative active site [active] 643867002113 Zn binding site [ion binding]; other site 643867002114 Membrane protein of unknown function; Region: DUF360; pfam04020 643867002115 DinB superfamily; Region: DinB_2; pfam12867 643867002116 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 643867002117 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 643867002118 dimer interface [polypeptide binding]; other site 643867002119 active site 643867002120 CoA binding pocket [chemical binding]; other site 643867002121 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 643867002122 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 643867002123 trimer interface [polypeptide binding]; other site 643867002124 putative metal binding site [ion binding]; other site 643867002125 YceI-like domain; Region: YceI; pfam04264 643867002126 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 643867002127 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 643867002128 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 643867002129 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 643867002130 TRAM domain; Region: TRAM; pfam01938 643867002131 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 643867002132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867002133 Walker A motif; other site 643867002134 ATP binding site [chemical binding]; other site 643867002135 Walker B motif; other site 643867002136 arginine finger; other site 643867002137 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 643867002138 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 643867002139 active site 643867002140 metal binding site [ion binding]; metal-binding site 643867002141 homotetramer interface [polypeptide binding]; other site 643867002142 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 643867002143 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 643867002144 active site 643867002145 substrate binding site [chemical binding]; other site 643867002146 metal binding site [ion binding]; metal-binding site 643867002147 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 643867002148 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 643867002149 dimer interface [polypeptide binding]; other site 643867002150 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 643867002151 active site 643867002152 Fe binding site [ion binding]; other site 643867002153 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 643867002154 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 643867002155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 643867002156 GAF domain; Region: GAF_3; pfam13492 643867002157 GAF domain; Region: GAF_2; pfam13185 643867002158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867002159 PAS domain; Region: PAS_9; pfam13426 643867002160 putative active site [active] 643867002161 heme pocket [chemical binding]; other site 643867002162 ATP-dependent DNA ligase; Validated; Region: PRK09247 643867002163 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 643867002164 active site 643867002165 DNA binding site [nucleotide binding] 643867002166 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 643867002167 DNA binding site [nucleotide binding] 643867002168 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 643867002169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 643867002170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867002171 ATP binding site [chemical binding]; other site 643867002172 putative Mg++ binding site [ion binding]; other site 643867002173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867002174 nucleotide binding region [chemical binding]; other site 643867002175 ATP-binding site [chemical binding]; other site 643867002176 DEAD/H associated; Region: DEAD_assoc; pfam08494 643867002177 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 643867002178 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 643867002179 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 643867002180 putative active site [active] 643867002181 putative metal binding site [ion binding]; other site 643867002182 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 643867002183 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867002184 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 643867002185 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 643867002186 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 643867002187 Bacitracin resistance protein BacA; Region: BacA; pfam02673 643867002188 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 643867002189 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 643867002190 RNA binding site [nucleotide binding]; other site 643867002191 active site 643867002192 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 643867002193 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 643867002194 active site 643867002195 Riboflavin kinase; Region: Flavokinase; pfam01687 643867002196 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 643867002197 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 643867002198 Peptidase family M48; Region: Peptidase_M48; pfam01435 643867002199 gliding motility-associated protein GldC; Region: GldC; TIGR03515 643867002200 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 643867002201 pentamer interface [polypeptide binding]; other site 643867002202 dodecaamer interface [polypeptide binding]; other site 643867002203 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867002204 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 643867002205 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 643867002206 DNA-binding site [nucleotide binding]; DNA binding site 643867002207 RNA-binding motif; other site 643867002208 methionine sulfoxide reductase B; Provisional; Region: PRK00222 643867002209 SelR domain; Region: SelR; pfam01641 643867002210 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 643867002211 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 643867002212 substrate binding pocket [chemical binding]; other site 643867002213 membrane-bound complex binding site; other site 643867002214 hinge residues; other site 643867002215 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 643867002216 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 643867002217 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 643867002218 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 643867002219 dimer interface [polypeptide binding]; other site 643867002220 active site 643867002221 hypothetical protein; Reviewed; Region: PRK12497 643867002222 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 643867002223 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 643867002224 putative active site [active] 643867002225 hypothetical protein; Provisional; Region: PRK08609 643867002226 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 643867002227 metal binding triad [ion binding]; metal-binding site 643867002228 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 643867002229 active site 643867002230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 643867002231 active site 643867002232 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 643867002233 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 643867002234 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 643867002235 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 643867002236 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 643867002237 dimer interface [polypeptide binding]; other site 643867002238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867002239 catalytic residue [active] 643867002240 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 643867002241 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 643867002242 TRAM domain; Region: TRAM; pfam01938 643867002243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867002244 S-adenosylmethionine binding site [chemical binding]; other site 643867002245 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867002246 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867002247 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867002248 ligand binding site [chemical binding]; other site 643867002249 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 643867002250 Found in ATP-dependent protease La (LON); Region: LON; smart00464 643867002251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867002252 Walker A motif; other site 643867002253 ATP binding site [chemical binding]; other site 643867002254 Walker B motif; other site 643867002255 arginine finger; other site 643867002256 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 643867002257 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 643867002258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867002259 Walker A motif; other site 643867002260 ATP binding site [chemical binding]; other site 643867002261 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 643867002262 Walker B motif; other site 643867002263 arginine finger; other site 643867002264 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 643867002265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867002266 short chain dehydrogenase; Provisional; Region: PRK06924 643867002267 NAD(P) binding site [chemical binding]; other site 643867002268 active site 643867002269 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867002270 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 643867002271 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867002272 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 643867002273 Family description; Region: UvrD_C_2; pfam13538 643867002274 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 643867002275 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867002276 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867002277 ligand binding site [chemical binding]; other site 643867002278 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 643867002279 Beta-lactamase; Region: Beta-lactamase; pfam00144 643867002280 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 643867002281 dihydrodipicolinate synthase; Region: dapA; TIGR00674 643867002282 dimer interface [polypeptide binding]; other site 643867002283 active site 643867002284 catalytic residue [active] 643867002285 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 643867002286 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 643867002287 nucleotide binding pocket [chemical binding]; other site 643867002288 K-X-D-G motif; other site 643867002289 catalytic site [active] 643867002290 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 643867002291 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 643867002292 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 643867002293 Dimer interface [polypeptide binding]; other site 643867002294 BRCT sequence motif; other site 643867002295 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 643867002296 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 643867002297 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 643867002298 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 643867002299 fumarylacetoacetase; Region: PLN02856 643867002300 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 643867002301 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 643867002302 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 643867002303 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 643867002304 active site 643867002305 HIGH motif; other site 643867002306 nucleotide binding site [chemical binding]; other site 643867002307 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 643867002308 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 643867002309 active site 643867002310 KMSKS motif; other site 643867002311 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 643867002312 tRNA binding surface [nucleotide binding]; other site 643867002313 anticodon binding site; other site 643867002314 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 643867002315 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 643867002316 Outer membrane efflux protein; Region: OEP; pfam02321 643867002317 Outer membrane efflux protein; Region: OEP; pfam02321 643867002318 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 643867002319 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867002320 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 643867002321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867002322 S-adenosylmethionine binding site [chemical binding]; other site 643867002323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 643867002324 Coenzyme A binding pocket [chemical binding]; other site 643867002325 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 643867002326 B12 binding site [chemical binding]; other site 643867002327 cobalt ligand [ion binding]; other site 643867002328 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 643867002329 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 643867002330 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 643867002331 AAA domain; Region: AAA_30; pfam13604 643867002332 AAA domain; Region: AAA_22; pfam13401 643867002333 Family description; Region: UvrD_C_2; pfam13538 643867002334 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 643867002335 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 643867002336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867002337 PAS domain; Region: PAS_9; pfam13426 643867002338 putative active site [active] 643867002339 heme pocket [chemical binding]; other site 643867002340 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 643867002341 GAF domain; Region: GAF_3; pfam13492 643867002342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867002343 PAS domain; Region: PAS_9; pfam13426 643867002344 putative active site [active] 643867002345 heme pocket [chemical binding]; other site 643867002346 PAS domain S-box; Region: sensory_box; TIGR00229 643867002347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867002348 putative active site [active] 643867002349 heme pocket [chemical binding]; other site 643867002350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867002351 dimer interface [polypeptide binding]; other site 643867002352 phosphorylation site [posttranslational modification] 643867002353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867002354 ATP binding site [chemical binding]; other site 643867002355 Mg2+ binding site [ion binding]; other site 643867002356 G-X-G motif; other site 643867002357 Response regulator receiver domain; Region: Response_reg; pfam00072 643867002358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867002359 active site 643867002360 phosphorylation site [posttranslational modification] 643867002361 intermolecular recognition site; other site 643867002362 dimerization interface [polypeptide binding]; other site 643867002363 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 643867002364 putative binding surface; other site 643867002365 active site 643867002366 Response regulator receiver domain; Region: Response_reg; pfam00072 643867002367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867002368 active site 643867002369 phosphorylation site [posttranslational modification] 643867002370 intermolecular recognition site; other site 643867002371 dimerization interface [polypeptide binding]; other site 643867002372 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 643867002373 putative hydrolase; Provisional; Region: PRK02113 643867002374 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 643867002375 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 643867002376 Domain of unknown function (DUF814); Region: DUF814; pfam05670 643867002377 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 643867002378 Part of AAA domain; Region: AAA_19; pfam13245 643867002379 Family description; Region: UvrD_C_2; pfam13538 643867002380 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 643867002381 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 643867002382 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 643867002383 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 643867002384 Predicted oxidoreductase [General function prediction only]; Region: COG3573 643867002385 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 643867002386 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 643867002387 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 643867002388 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 643867002389 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 643867002390 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 643867002391 active site 643867002392 methionine sulfoxide reductase A; Provisional; Region: PRK14054 643867002393 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 643867002394 ArsC family; Region: ArsC; pfam03960 643867002395 catalytic residues [active] 643867002396 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 643867002397 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 643867002398 active site 643867002399 Int/Topo IB signature motif; other site 643867002400 Dehydroquinase class II; Region: DHquinase_II; pfam01220 643867002401 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 643867002402 active site 643867002403 trimer interface [polypeptide binding]; other site 643867002404 dimer interface [polypeptide binding]; other site 643867002405 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 643867002406 active site 643867002407 dimer interfaces [polypeptide binding]; other site 643867002408 catalytic residues [active] 643867002409 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 643867002410 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 643867002411 active site 643867002412 FMN binding site [chemical binding]; other site 643867002413 substrate binding site [chemical binding]; other site 643867002414 3Fe-4S cluster binding site [ion binding]; other site 643867002415 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 643867002416 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 643867002417 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 643867002418 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 643867002419 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 643867002420 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 643867002421 RNA binding site [nucleotide binding]; other site 643867002422 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 643867002423 RNA binding site [nucleotide binding]; other site 643867002424 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 643867002425 RNA binding site [nucleotide binding]; other site 643867002426 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 643867002427 RNA binding site [nucleotide binding]; other site 643867002428 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 643867002429 RNA binding site [nucleotide binding]; other site 643867002430 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 643867002431 RNA binding site [nucleotide binding]; other site 643867002432 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 643867002433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867002434 Walker A/P-loop; other site 643867002435 ATP binding site [chemical binding]; other site 643867002436 Q-loop/lid; other site 643867002437 ABC transporter signature motif; other site 643867002438 Walker B; other site 643867002439 D-loop; other site 643867002440 H-loop/switch region; other site 643867002441 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 643867002442 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 643867002443 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 643867002444 oligomerisation interface [polypeptide binding]; other site 643867002445 mobile loop; other site 643867002446 roof hairpin; other site 643867002447 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 643867002448 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 643867002449 ring oligomerisation interface [polypeptide binding]; other site 643867002450 ATP/Mg binding site [chemical binding]; other site 643867002451 stacking interactions; other site 643867002452 hinge regions; other site 643867002453 tellurium resistance terB-like protein; Region: terB_like; cd07177 643867002454 metal binding site [ion binding]; metal-binding site 643867002455 Haemolysin-III related; Region: HlyIII; cl03831 643867002456 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 643867002457 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 643867002458 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 643867002459 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 643867002460 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 643867002461 Catalytic dyad [active] 643867002462 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 643867002463 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 643867002464 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 643867002465 FOG: WD40 repeat [General function prediction only]; Region: COG2319 643867002466 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 643867002467 structural tetrad; other site 643867002468 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867002469 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867002470 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 643867002471 dimer interface [polypeptide binding]; other site 643867002472 Citrate synthase; Region: Citrate_synt; pfam00285 643867002473 active site 643867002474 citrylCoA binding site [chemical binding]; other site 643867002475 NADH binding [chemical binding]; other site 643867002476 cationic pore residues; other site 643867002477 oxalacetate/citrate binding site [chemical binding]; other site 643867002478 coenzyme A binding site [chemical binding]; other site 643867002479 catalytic triad [active] 643867002480 Acyl CoA binding protein; Region: ACBP; pfam00887 643867002481 acyl-CoA binding pocket [chemical binding]; other site 643867002482 CoA binding site [chemical binding]; other site 643867002483 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 643867002484 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 643867002485 inhibitor-cofactor binding pocket; inhibition site 643867002486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867002487 catalytic residue [active] 643867002488 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 643867002489 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867002490 catalytic residues [active] 643867002491 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 643867002492 Fatty acid desaturase; Region: FA_desaturase; pfam00487 643867002493 Di-iron ligands [ion binding]; other site 643867002494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867002495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 643867002496 putative substrate translocation pore; other site 643867002497 PspC domain; Region: PspC; cl00864 643867002498 OmpA family; Region: OmpA; pfam00691 643867002499 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867002500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867002501 TPR motif; other site 643867002502 binding surface 643867002503 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 643867002504 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 643867002505 alpha subunit interface [polypeptide binding]; other site 643867002506 TPP binding site [chemical binding]; other site 643867002507 heterodimer interface [polypeptide binding]; other site 643867002508 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 643867002509 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 643867002510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867002511 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867002512 DNA binding residues [nucleotide binding] 643867002513 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 643867002514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867002515 Walker A motif; other site 643867002516 ATP binding site [chemical binding]; other site 643867002517 Walker B motif; other site 643867002518 Family description; Region: UvrD_C_2; pfam13538 643867002519 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 643867002520 CoenzymeA binding site [chemical binding]; other site 643867002521 subunit interaction site [polypeptide binding]; other site 643867002522 PHB binding site; other site 643867002523 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 643867002524 nudix motif; other site 643867002525 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 643867002526 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 643867002527 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 643867002528 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 643867002529 active site 643867002530 nucleotide binding site [chemical binding]; other site 643867002531 HIGH motif; other site 643867002532 KMSKS motif; other site 643867002533 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 643867002534 active site 643867002535 catalytic residues [active] 643867002536 metal binding site [ion binding]; metal-binding site 643867002537 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 643867002538 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 643867002539 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 643867002540 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 643867002541 inhibitor-cofactor binding pocket; inhibition site 643867002542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867002543 catalytic residue [active] 643867002544 6-phosphofructokinase; Provisional; Region: PRK03202 643867002545 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 643867002546 active site 643867002547 ADP/pyrophosphate binding site [chemical binding]; other site 643867002548 dimerization interface [polypeptide binding]; other site 643867002549 allosteric effector site; other site 643867002550 fructose-1,6-bisphosphate binding site; other site 643867002551 GSCFA family; Region: GSCFA; pfam08885 643867002552 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 643867002553 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 643867002554 catalytic residues [active] 643867002555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867002556 primosomal protein N' Region: priA; TIGR00595 643867002557 ATP binding site [chemical binding]; other site 643867002558 putative Mg++ binding site [ion binding]; other site 643867002559 helicase superfamily c-terminal domain; Region: HELICc; smart00490 643867002560 ATP-binding site [chemical binding]; other site 643867002561 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 643867002562 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867002563 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 643867002564 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 643867002565 acyl-activating enzyme (AAE) consensus motif; other site 643867002566 putative AMP binding site [chemical binding]; other site 643867002567 putative active site [active] 643867002568 putative CoA binding site [chemical binding]; other site 643867002569 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 643867002570 putative ABC transporter; Region: ycf24; CHL00085 643867002571 FeS assembly ATPase SufC; Region: sufC; TIGR01978 643867002572 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 643867002573 Walker A/P-loop; other site 643867002574 ATP binding site [chemical binding]; other site 643867002575 Q-loop/lid; other site 643867002576 ABC transporter signature motif; other site 643867002577 Walker B; other site 643867002578 D-loop; other site 643867002579 H-loop/switch region; other site 643867002580 FeS assembly protein SufD; Region: sufD; TIGR01981 643867002581 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 643867002582 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 643867002583 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 643867002584 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867002585 catalytic residue [active] 643867002586 Fe-S metabolism associated domain; Region: SufE; cl00951 643867002587 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 643867002588 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 643867002589 amidase; Provisional; Region: PRK06707 643867002590 Amidase; Region: Amidase; cl11426 643867002591 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 643867002592 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 643867002593 ATP binding site [chemical binding]; other site 643867002594 Mg++ binding site [ion binding]; other site 643867002595 motif III; other site 643867002596 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867002597 nucleotide binding region [chemical binding]; other site 643867002598 ATP-binding site [chemical binding]; other site 643867002599 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 643867002600 RNA binding site [nucleotide binding]; other site 643867002601 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 643867002602 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 643867002603 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 643867002604 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 643867002605 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 643867002606 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 643867002607 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 643867002608 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 643867002609 catalytic motif [active] 643867002610 Zn binding site [ion binding]; other site 643867002611 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 643867002612 FAD binding domain; Region: FAD_binding_4; pfam01565 643867002613 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 643867002614 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 643867002615 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 643867002616 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 643867002617 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 643867002618 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 643867002619 dimerization interface [polypeptide binding]; other site 643867002620 active site 643867002621 DNA primase; Validated; Region: dnaG; PRK05667 643867002622 CHC2 zinc finger; Region: zf-CHC2; pfam01807 643867002623 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 643867002624 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 643867002625 active site 643867002626 metal binding site [ion binding]; metal-binding site 643867002627 interdomain interaction site; other site 643867002628 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 643867002629 antiporter inner membrane protein; Provisional; Region: PRK11670 643867002630 Domain of unknown function DUF59; Region: DUF59; pfam01883 643867002631 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 643867002632 NifU-like domain; Region: NifU; pfam01106 643867002633 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 643867002634 active site 643867002635 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867002636 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 643867002637 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 643867002638 ATP-grasp domain; Region: ATP-grasp_4; cl17255 643867002639 ATP-grasp domain; Region: ATP-grasp_4; cl17255 643867002640 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 643867002641 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 643867002642 ATP-grasp domain; Region: ATP-grasp_4; cl17255 643867002643 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 643867002644 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 643867002645 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 643867002646 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867002647 peptide chain release factor 2; Validated; Region: prfB; PRK00578 643867002648 This domain is found in peptide chain release factors; Region: PCRF; smart00937 643867002649 RF-1 domain; Region: RF-1; pfam00472 643867002650 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 643867002651 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 643867002652 homodimer interface [polypeptide binding]; other site 643867002653 substrate-cofactor binding pocket; other site 643867002654 catalytic residue [active] 643867002655 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 643867002656 SprT-like family; Region: SprT-like; pfam10263 643867002657 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 643867002658 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 643867002659 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 643867002660 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 643867002661 Protein of unknown function (DUF779); Region: DUF779; pfam05610 643867002662 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 643867002663 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 643867002664 NAD(P) binding site [chemical binding]; other site 643867002665 catalytic residues [active] 643867002666 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 643867002667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 643867002668 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 643867002669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 643867002670 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 643867002671 glutaminase; Provisional; Region: PRK00971 643867002672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867002673 putative substrate translocation pore; other site 643867002674 Major Facilitator Superfamily; Region: MFS_1; pfam07690 643867002675 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 643867002676 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 643867002677 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 643867002678 proline aminopeptidase P II; Provisional; Region: PRK10879 643867002679 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 643867002680 active site 643867002681 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 643867002682 Lamin Tail Domain; Region: LTD; pfam00932 643867002683 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867002684 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 643867002685 malate dehydrogenase; Reviewed; Region: PRK06223 643867002686 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 643867002687 dimer interface [polypeptide binding]; other site 643867002688 NAD(P) binding site [chemical binding]; other site 643867002689 tetramer (dimer of dimers) interface [polypeptide binding]; other site 643867002690 substrate binding site [chemical binding]; other site 643867002691 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867002692 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 643867002693 ligand binding site [chemical binding]; other site 643867002694 flexible hinge region; other site 643867002695 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 643867002696 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 643867002697 Ligand Binding Site [chemical binding]; other site 643867002698 TilS substrate C-terminal domain; Region: TilS_C; smart00977 643867002699 OstA-like protein; Region: OstA_2; pfam13100 643867002700 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867002701 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 643867002702 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 643867002703 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 643867002704 Peptidase family M48; Region: Peptidase_M48; pfam01435 643867002705 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 643867002706 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 643867002707 Peptidase family M23; Region: Peptidase_M23; pfam01551 643867002708 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 643867002709 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 643867002710 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 643867002711 catalytic triad [active] 643867002712 transketolase; Reviewed; Region: PRK05899 643867002713 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 643867002714 TPP-binding site [chemical binding]; other site 643867002715 dimer interface [polypeptide binding]; other site 643867002716 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 643867002717 metal ion-dependent adhesion site (MIDAS); other site 643867002718 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 643867002719 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 643867002720 PYR/PP interface [polypeptide binding]; other site 643867002721 dimer interface [polypeptide binding]; other site 643867002722 TPP binding site [chemical binding]; other site 643867002723 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 643867002724 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 643867002725 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 643867002726 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 643867002727 substrate binding pocket [chemical binding]; other site 643867002728 chain length determination region; other site 643867002729 substrate-Mg2+ binding site; other site 643867002730 catalytic residues [active] 643867002731 aspartate-rich region 1; other site 643867002732 active site lid residues [active] 643867002733 aspartate-rich region 2; other site 643867002734 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 643867002735 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 643867002736 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867002737 Calx-beta domain; Region: Calx-beta; cl02522 643867002738 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 643867002739 starch binding outer membrane protein SusD; Region: SusD; cd08977 643867002740 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 643867002741 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867002742 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 643867002743 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867002744 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 643867002745 SnoaL-like domain; Region: SnoaL_3; pfam13474 643867002746 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 643867002747 catalytic residues [active] 643867002748 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 643867002749 NAD binding site [chemical binding]; other site 643867002750 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 643867002751 active site 643867002752 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 643867002753 putative active site [active] 643867002754 dimerization interface [polypeptide binding]; other site 643867002755 putative tRNAtyr binding site [nucleotide binding]; other site 643867002756 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 643867002757 DNA photolyase; Region: DNA_photolyase; pfam00875 643867002758 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 643867002759 pyruvate carboxylase; Reviewed; Region: PRK12999 643867002760 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 643867002761 ATP-grasp domain; Region: ATP-grasp_4; cl17255 643867002762 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 643867002763 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 643867002764 active site 643867002765 catalytic residues [active] 643867002766 metal binding site [ion binding]; metal-binding site 643867002767 homodimer binding site [polypeptide binding]; other site 643867002768 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 643867002769 carboxyltransferase (CT) interaction site; other site 643867002770 biotinylation site [posttranslational modification]; other site 643867002771 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 643867002772 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 643867002773 active site 643867002774 HIGH motif; other site 643867002775 KMSKS motif; other site 643867002776 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 643867002777 tRNA binding surface [nucleotide binding]; other site 643867002778 anticodon binding site; other site 643867002779 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 643867002780 dimer interface [polypeptide binding]; other site 643867002781 putative tRNA-binding site [nucleotide binding]; other site 643867002782 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 643867002783 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 643867002784 Active Sites [active] 643867002785 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 643867002786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 643867002787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867002788 dimer interface [polypeptide binding]; other site 643867002789 phosphorylation site [posttranslational modification] 643867002790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867002791 ATP binding site [chemical binding]; other site 643867002792 Mg2+ binding site [ion binding]; other site 643867002793 G-X-G motif; other site 643867002794 extended (e) SDRs; Region: SDR_e; cd08946 643867002795 NADH(P)-binding; Region: NAD_binding_10; pfam13460 643867002796 NAD(P) binding site [chemical binding]; other site 643867002797 active site 643867002798 substrate binding site [chemical binding]; other site 643867002799 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 643867002800 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867002801 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867002802 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867002803 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867002804 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867002805 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867002806 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867002807 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867002808 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867002809 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867002810 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867002811 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867002812 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 643867002813 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 643867002814 inhibitor-cofactor binding pocket; inhibition site 643867002815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867002816 catalytic residue [active] 643867002817 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 643867002818 AAA domain; Region: AAA_26; pfam13500 643867002819 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 643867002820 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 643867002821 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867002822 catalytic residue [active] 643867002823 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867002824 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867002825 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867002826 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867002827 ligand binding site [chemical binding]; other site 643867002828 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867002829 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867002830 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867002831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867002832 binding surface 643867002833 TPR motif; other site 643867002834 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867002835 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867002836 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867002837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867002838 binding surface 643867002839 TPR motif; other site 643867002840 CHAT domain; Region: CHAT; pfam12770 643867002841 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 643867002842 Zn binding site [ion binding]; other site 643867002843 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 643867002844 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 643867002845 active site 643867002846 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 643867002847 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 643867002848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867002849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 643867002850 Bacterial transcriptional repressor; Region: TetR; pfam13972 643867002851 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 643867002852 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 643867002853 homodimer interface [polypeptide binding]; other site 643867002854 metal binding site [ion binding]; metal-binding site 643867002855 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 643867002856 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 643867002857 active site 643867002858 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867002859 AMP nucleosidase; Provisional; Region: PRK07115 643867002860 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 643867002861 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 643867002862 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 643867002863 homodimer interface [polypeptide binding]; other site 643867002864 substrate-cofactor binding pocket; other site 643867002865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867002866 catalytic residue [active] 643867002867 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 643867002868 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 643867002869 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 643867002870 putative L-serine binding site [chemical binding]; other site 643867002871 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 643867002872 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 643867002873 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 643867002874 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867002875 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 643867002876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 643867002877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 643867002878 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 643867002879 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 643867002880 substrate binding site [chemical binding]; other site 643867002881 active site 643867002882 catalytic residues [active] 643867002883 heterodimer interface [polypeptide binding]; other site 643867002884 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 643867002885 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 643867002886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867002887 catalytic residue [active] 643867002888 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 643867002889 active site 643867002890 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 643867002891 active site 643867002892 ribulose/triose binding site [chemical binding]; other site 643867002893 phosphate binding site [ion binding]; other site 643867002894 substrate (anthranilate) binding pocket [chemical binding]; other site 643867002895 product (indole) binding pocket [chemical binding]; other site 643867002896 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 643867002897 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 643867002898 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 643867002899 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 643867002900 Glutamine amidotransferase class-I; Region: GATase; pfam00117 643867002901 glutamine binding [chemical binding]; other site 643867002902 catalytic triad [active] 643867002903 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 643867002904 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 643867002905 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 643867002906 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 643867002907 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 643867002908 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 643867002909 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 643867002910 putative active site [active] 643867002911 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 643867002912 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 643867002913 ATP-grasp domain; Region: ATP-grasp_4; cl17255 643867002914 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 643867002915 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 643867002916 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 643867002917 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 643867002918 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 643867002919 active site 643867002920 catalytic site [active] 643867002921 substrate binding site [chemical binding]; other site 643867002922 ribonuclease R; Region: RNase_R; TIGR02063 643867002923 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 643867002924 RNB domain; Region: RNB; pfam00773 643867002925 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 643867002926 RNA binding site [nucleotide binding]; other site 643867002927 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 643867002928 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 643867002929 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 643867002930 active site 643867002931 Methyltransferase domain; Region: Methyltransf_31; pfam13847 643867002932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867002933 S-adenosylmethionine binding site [chemical binding]; other site 643867002934 SnoaL-like domain; Region: SnoaL_2; pfam12680 643867002935 acyl transferase; Provisional; Region: luxD; PRK13604 643867002936 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 643867002937 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 643867002938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867002939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867002940 DNA binding residues [nucleotide binding] 643867002941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867002942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 643867002943 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 643867002944 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 643867002945 Protein export membrane protein; Region: SecD_SecF; cl14618 643867002946 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 643867002947 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 643867002948 Walker A/P-loop; other site 643867002949 ATP binding site [chemical binding]; other site 643867002950 Q-loop/lid; other site 643867002951 ABC transporter signature motif; other site 643867002952 Walker B; other site 643867002953 D-loop; other site 643867002954 H-loop/switch region; other site 643867002955 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 643867002956 Protein export membrane protein; Region: SecD_SecF; cl14618 643867002957 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 643867002958 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867002959 Outer membrane efflux protein; Region: OEP; pfam02321 643867002960 Outer membrane efflux protein; Region: OEP; pfam02321 643867002961 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 643867002962 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 643867002963 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 643867002964 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 643867002965 Walker A/P-loop; other site 643867002966 ATP binding site [chemical binding]; other site 643867002967 Q-loop/lid; other site 643867002968 ABC transporter signature motif; other site 643867002969 Walker B; other site 643867002970 D-loop; other site 643867002971 H-loop/switch region; other site 643867002972 Predicted transcriptional regulators [Transcription]; Region: COG1725 643867002973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 643867002974 DNA-binding site [nucleotide binding]; DNA binding site 643867002975 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 643867002976 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 643867002977 Walker A/P-loop; other site 643867002978 ATP binding site [chemical binding]; other site 643867002979 Q-loop/lid; other site 643867002980 ABC transporter signature motif; other site 643867002981 Walker B; other site 643867002982 D-loop; other site 643867002983 H-loop/switch region; other site 643867002984 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 643867002985 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 643867002986 active site 643867002987 dimer interface [polypeptide binding]; other site 643867002988 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 643867002989 dimer interface [polypeptide binding]; other site 643867002990 active site 643867002991 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 643867002992 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 643867002993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867002994 Major Facilitator Superfamily; Region: MFS_1; pfam07690 643867002995 putative substrate translocation pore; other site 643867002996 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 643867002997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867002998 catalytic residue [active] 643867002999 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 643867003000 Domain of unknown function (DUF4348); Region: DUF4348; pfam14254 643867003001 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 643867003002 catalytic center binding site [active] 643867003003 ATP binding site [chemical binding]; other site 643867003004 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 643867003005 tandem repeat interface [polypeptide binding]; other site 643867003006 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 643867003007 oligomer interface [polypeptide binding]; other site 643867003008 active site residues [active] 643867003009 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 643867003010 tandem repeat interface [polypeptide binding]; other site 643867003011 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 643867003012 oligomer interface [polypeptide binding]; other site 643867003013 active site residues [active] 643867003014 biotin synthase; Region: bioB; TIGR00433 643867003015 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 643867003016 FeS/SAM binding site; other site 643867003017 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 643867003018 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 643867003019 active site 643867003020 catalytic site [active] 643867003021 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 643867003022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867003023 S-adenosylmethionine binding site [chemical binding]; other site 643867003024 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 643867003025 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867003026 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 643867003027 DNA binding residues [nucleotide binding] 643867003028 4Fe-4S binding domain; Region: Fer4; cl02805 643867003029 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 643867003030 CAAX protease self-immunity; Region: Abi; pfam02517 643867003031 Beta-lactamase; Region: Beta-lactamase; pfam00144 643867003032 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 643867003033 Histidine kinase; Region: His_kinase; pfam06580 643867003034 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 643867003035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867003036 active site 643867003037 phosphorylation site [posttranslational modification] 643867003038 intermolecular recognition site; other site 643867003039 dimerization interface [polypeptide binding]; other site 643867003040 LytTr DNA-binding domain; Region: LytTR; smart00850 643867003041 Caspase domain; Region: Peptidase_C14; pfam00656 643867003042 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 643867003043 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867003044 Ca2+ binding site [ion binding]; other site 643867003045 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867003046 Ca2+ binding site [ion binding]; other site 643867003047 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867003048 Ca2+ binding site [ion binding]; other site 643867003049 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 643867003050 Ca2+ binding site [ion binding]; other site 643867003051 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867003052 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 643867003053 Tup N-terminal; Region: Tup_N; pfam08581 643867003054 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 643867003055 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 643867003056 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 643867003057 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 643867003058 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 643867003059 YciI-like protein; Reviewed; Region: PRK12866 643867003060 OsmC-like protein; Region: OsmC; cl00767 643867003061 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 643867003062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867003063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867003064 DNA binding residues [nucleotide binding] 643867003065 Putative zinc-finger; Region: zf-HC2; pfam13490 643867003066 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867003067 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 643867003068 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 643867003069 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 643867003070 NAD(P) binding site [chemical binding]; other site 643867003071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 643867003072 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 643867003073 putative transposase OrfB; Reviewed; Region: PHA02517 643867003074 Integrase core domain; Region: rve; pfam00665 643867003075 Integrase core domain; Region: rve_3; pfam13683 643867003076 Transposase; Region: HTH_Tnp_1; pfam01527 643867003077 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 643867003078 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 643867003079 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 643867003080 catalytic core [active] 643867003081 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 643867003082 CoenzymeA binding site [chemical binding]; other site 643867003083 subunit interaction site [polypeptide binding]; other site 643867003084 PHB binding site; other site 643867003085 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 643867003086 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 643867003087 MarR family; Region: MarR_2; cl17246 643867003088 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 643867003089 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 643867003090 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 643867003091 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 643867003092 GDP-binding site [chemical binding]; other site 643867003093 ACT binding site; other site 643867003094 IMP binding site; other site 643867003095 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 643867003096 anti sigma factor interaction site; other site 643867003097 regulatory phosphorylation site [posttranslational modification]; other site 643867003098 ferric uptake regulator; Provisional; Region: fur; PRK09462 643867003099 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 643867003100 metal binding site 2 [ion binding]; metal-binding site 643867003101 putative DNA binding helix; other site 643867003102 metal binding site 1 [ion binding]; metal-binding site 643867003103 dimer interface [polypeptide binding]; other site 643867003104 structural Zn2+ binding site [ion binding]; other site 643867003105 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 643867003106 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 643867003107 Zn2+ binding site [ion binding]; other site 643867003108 Mg2+ binding site [ion binding]; other site 643867003109 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 643867003110 synthetase active site [active] 643867003111 NTP binding site [chemical binding]; other site 643867003112 metal binding site [ion binding]; metal-binding site 643867003113 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 643867003114 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 643867003115 trigger factor; Region: tig; TIGR00115 643867003116 Clp protease; Region: CLP_protease; pfam00574 643867003117 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 643867003118 oligomer interface [polypeptide binding]; other site 643867003119 active site residues [active] 643867003120 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 643867003121 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 643867003122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867003123 Walker A motif; other site 643867003124 ATP binding site [chemical binding]; other site 643867003125 Walker B motif; other site 643867003126 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 643867003127 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 643867003128 ATP-grasp domain; Region: ATP-grasp_4; cl17255 643867003129 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 643867003130 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 643867003131 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 643867003132 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 643867003133 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 643867003134 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 643867003135 homodimer interface [polypeptide binding]; other site 643867003136 substrate-cofactor binding pocket; other site 643867003137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867003138 catalytic residue [active] 643867003139 YhhN-like protein; Region: YhhN; pfam07947 643867003140 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867003141 putative carbohydrate kinase; Provisional; Region: PRK10565 643867003142 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 643867003143 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 643867003144 putative substrate binding site [chemical binding]; other site 643867003145 putative ATP binding site [chemical binding]; other site 643867003146 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 643867003147 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 643867003148 CoA binding domain; Region: CoA_binding; smart00881 643867003149 CoA-ligase; Region: Ligase_CoA; pfam00549 643867003150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 643867003151 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 643867003152 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 643867003153 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 643867003154 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 643867003155 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 643867003156 active site residue [active] 643867003157 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 643867003158 multidrug efflux protein; Reviewed; Region: PRK01766 643867003159 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 643867003160 cation binding site [ion binding]; other site 643867003161 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003162 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003164 binding surface 643867003165 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003166 TPR motif; other site 643867003167 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003168 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003170 binding surface 643867003171 TPR motif; other site 643867003172 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003173 CHAT domain; Region: CHAT; pfam12770 643867003174 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867003175 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 643867003176 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 643867003177 oligomer interface [polypeptide binding]; other site 643867003178 active site 643867003179 metal binding site [ion binding]; metal-binding site 643867003180 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 643867003181 DNA-binding site [nucleotide binding]; DNA binding site 643867003182 RNA-binding motif; other site 643867003183 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 643867003184 catalytic core [active] 643867003185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003186 binding surface 643867003187 TPR motif; other site 643867003188 TPR repeat; Region: TPR_11; pfam13414 643867003189 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 643867003190 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 643867003191 Asp-box motif; other site 643867003192 Peptidase family M23; Region: Peptidase_M23; pfam01551 643867003193 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 643867003194 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 643867003195 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867003196 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 643867003197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867003198 Surface antigen; Region: Bac_surface_Ag; pfam01103 643867003199 Haemolytic domain; Region: Haemolytic; pfam01809 643867003200 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 643867003201 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 643867003202 NAD+ synthase (glutamine-hydrolysing); Region: PLN02339 643867003203 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 643867003204 multimer interface [polypeptide binding]; other site 643867003205 active site 643867003206 catalytic triad [active] 643867003207 protein interface 1 [polypeptide binding]; other site 643867003208 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 643867003209 Ligand Binding Site [chemical binding]; other site 643867003210 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 643867003211 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 643867003212 dimerization interface [polypeptide binding]; other site 643867003213 active site 643867003214 metal binding site [ion binding]; metal-binding site 643867003215 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 643867003216 dsRNA binding site [nucleotide binding]; other site 643867003217 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 643867003218 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 643867003219 dimer interface [polypeptide binding]; other site 643867003220 active site 643867003221 acyl carrier protein; Provisional; Region: acpP; PRK00982 643867003222 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 643867003223 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 643867003224 domain interfaces; other site 643867003225 active site 643867003226 Response regulator receiver domain; Region: Response_reg; pfam00072 643867003227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867003228 active site 643867003229 phosphorylation site [posttranslational modification] 643867003230 intermolecular recognition site; other site 643867003231 PAS domain S-box; Region: sensory_box; TIGR00229 643867003232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 643867003233 putative active site [active] 643867003234 heme pocket [chemical binding]; other site 643867003235 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 643867003236 Histidine kinase; Region: HisKA_3; pfam07730 643867003237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867003238 ATP binding site [chemical binding]; other site 643867003239 Mg2+ binding site [ion binding]; other site 643867003240 G-X-G motif; other site 643867003241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 643867003242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867003243 active site 643867003244 phosphorylation site [posttranslational modification] 643867003245 intermolecular recognition site; other site 643867003246 dimerization interface [polypeptide binding]; other site 643867003247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 643867003248 DNA binding residues [nucleotide binding] 643867003249 dimerization interface [polypeptide binding]; other site 643867003250 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 643867003251 Mechanosensitive ion channel; Region: MS_channel; pfam00924 643867003252 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 643867003253 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 643867003254 active site 643867003255 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 643867003256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867003257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867003258 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 643867003259 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 643867003260 CoA binding domain; Region: CoA_binding_2; pfam13380 643867003261 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 643867003262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 643867003263 dimerization interface [polypeptide binding]; other site 643867003264 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 643867003265 GAF domain; Region: GAF_3; pfam13492 643867003266 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 643867003267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 643867003268 active site 643867003269 motif I; other site 643867003270 motif II; other site 643867003271 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 643867003272 putative active site pocket [active] 643867003273 4-fold oligomerization interface [polypeptide binding]; other site 643867003274 metal binding residues [ion binding]; metal-binding site 643867003275 3-fold/trimer interface [polypeptide binding]; other site 643867003276 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 643867003277 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 643867003278 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 643867003279 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 643867003280 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 643867003281 active site 643867003282 HIGH motif; other site 643867003283 nucleotide binding site [chemical binding]; other site 643867003284 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 643867003285 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 643867003286 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 643867003287 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 643867003288 active site 643867003289 KMSKS motif; other site 643867003290 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 643867003291 tRNA binding surface [nucleotide binding]; other site 643867003292 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 643867003293 GH3 auxin-responsive promoter; Region: GH3; pfam03321 643867003294 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 643867003295 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 643867003296 catalytic residue [active] 643867003297 Protein of unknown function (DUF423); Region: DUF423; pfam04241 643867003298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867003299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867003300 acetyl-CoA C-acetyltransferase; Region: PLN02644 643867003301 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 643867003302 dimer interface [polypeptide binding]; other site 643867003303 active site 643867003304 von Willebrand factor type A domain; Region: VWA_2; pfam13519 643867003305 metal ion-dependent adhesion site (MIDAS); other site 643867003306 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 643867003307 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 643867003308 Int/Topo IB signature motif; other site 643867003309 DNA polymerase III PolC; Validated; Region: polC; PRK00448 643867003310 Helix-turn-helix domain; Region: HTH_17; pfam12728 643867003311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867003312 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 643867003313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 643867003314 Walker A/P-loop; other site 643867003315 ATP binding site [chemical binding]; other site 643867003316 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 643867003317 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 643867003318 metal binding site 2 [ion binding]; metal-binding site 643867003319 putative DNA binding helix; other site 643867003320 metal binding site 1 [ion binding]; metal-binding site 643867003321 dimer interface [polypeptide binding]; other site 643867003322 structural Zn2+ binding site [ion binding]; other site 643867003323 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 643867003324 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 643867003325 Heavy-metal-associated domain; Region: HMA; pfam00403 643867003326 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 643867003327 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 643867003328 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 643867003329 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867003330 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 643867003331 Outer membrane efflux protein; Region: OEP; pfam02321 643867003332 Outer membrane efflux protein; Region: OEP; pfam02321 643867003333 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 643867003334 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 643867003335 Virulence protein [General function prediction only]; Region: COG3943 643867003336 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 643867003337 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 643867003338 putative DNA binding site [nucleotide binding]; other site 643867003339 putative Zn2+ binding site [ion binding]; other site 643867003340 MerT mercuric transport protein; Region: MerT; cl03578 643867003341 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 643867003342 metal-binding site [ion binding] 643867003343 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 643867003344 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 643867003345 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 643867003346 peptide chain release factor 1; Provisional; Region: PRK04011 643867003347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867003348 binding surface 643867003349 Tetratricopeptide repeat; Region: TPR_16; pfam13432 643867003350 TPR motif; other site 643867003351 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867003352 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867003353 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867003354 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867003355 ligand binding site [chemical binding]; other site 643867003356 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 643867003357 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 643867003358 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867003359 PAS domain; Region: PAS_9; pfam13426 643867003360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867003361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867003362 dimer interface [polypeptide binding]; other site 643867003363 phosphorylation site [posttranslational modification] 643867003364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867003365 ATP binding site [chemical binding]; other site 643867003366 Mg2+ binding site [ion binding]; other site 643867003367 G-X-G motif; other site 643867003368 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 643867003369 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 643867003370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867003371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867003372 DNA binding residues [nucleotide binding] 643867003373 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867003374 LytTr DNA-binding domain; Region: LytTR; smart00850 643867003375 CAAX protease self-immunity; Region: Abi; pfam02517 643867003376 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 643867003377 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 643867003378 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 643867003379 SOUL heme-binding protein; Region: SOUL; pfam04832 643867003380 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867003381 Ligand Binding Site [chemical binding]; other site 643867003382 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 643867003383 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 643867003384 dimer interface [polypeptide binding]; other site 643867003385 putative anticodon binding site; other site 643867003386 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 643867003387 motif 1; other site 643867003388 active site 643867003389 motif 2; other site 643867003390 motif 3; other site 643867003391 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 643867003392 Proline dehydrogenase; Region: Pro_dh; cl03282 643867003393 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 643867003394 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 643867003395 Chorismate mutase type II; Region: CM_2; smart00830 643867003396 Prephenate dehydratase; Region: PDT; pfam00800 643867003397 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 643867003398 active site 643867003399 NTP binding site [chemical binding]; other site 643867003400 metal binding triad [ion binding]; metal-binding site 643867003401 antibiotic binding site [chemical binding]; other site 643867003402 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 643867003403 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 643867003404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 643867003405 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 643867003406 putative hydrophobic ligand binding site [chemical binding]; other site 643867003407 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 643867003408 putative hydrophobic ligand binding site [chemical binding]; other site 643867003409 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 643867003410 Chorismate mutase type II; Region: CM_2; smart00830 643867003411 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 643867003412 active site 643867003413 dimer interface [polypeptide binding]; other site 643867003414 metal binding site [ion binding]; metal-binding site 643867003415 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 643867003416 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 643867003417 hinge; other site 643867003418 active site 643867003419 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 643867003420 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 643867003421 intersubunit interface [polypeptide binding]; other site 643867003422 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 643867003423 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 643867003424 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 643867003425 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 643867003426 oligomer interface [polypeptide binding]; other site 643867003427 active site 643867003428 metal binding site [ion binding]; metal-binding site 643867003429 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867003430 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 643867003431 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 643867003432 active site 643867003433 Protein of unknown function, DUF479; Region: DUF479; cl01203 643867003434 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 643867003435 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 643867003436 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867003437 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867003438 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 643867003439 Fatty acid desaturase; Region: FA_desaturase; pfam00487 643867003440 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 643867003441 putative di-iron ligands [ion binding]; other site 643867003442 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 643867003443 hypothetical protein; Provisional; Region: PRK11622 643867003444 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 643867003445 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 643867003446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 643867003447 dimer interface [polypeptide binding]; other site 643867003448 conserved gate region; other site 643867003449 putative PBP binding loops; other site 643867003450 ABC-ATPase subunit interface; other site 643867003451 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 643867003452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 643867003453 dimer interface [polypeptide binding]; other site 643867003454 conserved gate region; other site 643867003455 putative PBP binding loops; other site 643867003456 ABC-ATPase subunit interface; other site 643867003457 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 643867003458 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 643867003459 Walker A/P-loop; other site 643867003460 ATP binding site [chemical binding]; other site 643867003461 Q-loop/lid; other site 643867003462 ABC transporter signature motif; other site 643867003463 Walker B; other site 643867003464 D-loop; other site 643867003465 H-loop/switch region; other site 643867003466 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 643867003467 active site 643867003468 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 643867003469 Phosphotransferase enzyme family; Region: APH; pfam01636 643867003470 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 643867003471 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867003472 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 643867003473 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867003474 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 643867003475 starch binding outer membrane protein SusD; Region: SusD; cl17845 643867003476 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 643867003477 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 643867003478 putative active site [active] 643867003479 PhoH-like protein; Region: PhoH; pfam02562 643867003480 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 643867003481 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 643867003482 tetramer interface [polypeptide binding]; other site 643867003483 TPP-binding site [chemical binding]; other site 643867003484 heterodimer interface [polypeptide binding]; other site 643867003485 phosphorylation loop region [posttranslational modification] 643867003486 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 643867003487 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 643867003488 PYR/PP interface [polypeptide binding]; other site 643867003489 dimer interface [polypeptide binding]; other site 643867003490 TPP binding site [chemical binding]; other site 643867003491 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 643867003492 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 643867003493 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 643867003494 catalytic loop [active] 643867003495 iron binding site [ion binding]; other site 643867003496 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 643867003497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 643867003498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 643867003499 Histidine kinase; Region: His_kinase; pfam06580 643867003500 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 643867003501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867003502 active site 643867003503 phosphorylation site [posttranslational modification] 643867003504 intermolecular recognition site; other site 643867003505 dimerization interface [polypeptide binding]; other site 643867003506 LytTr DNA-binding domain; Region: LytTR; smart00850 643867003507 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 643867003508 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 643867003509 CAAX protease self-immunity; Region: Abi; pfam02517 643867003510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 643867003511 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 643867003512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 643867003513 Predicted integral membrane protein [Function unknown]; Region: COG5616 643867003514 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 643867003515 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003516 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 643867003517 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 643867003518 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 643867003519 Acyltransferase family; Region: Acyl_transf_3; pfam01757 643867003520 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 643867003521 Beta-lactamase; Region: Beta-lactamase; pfam00144 643867003522 Predicted integral membrane protein [Function unknown]; Region: COG5616 643867003523 TPR repeat; Region: TPR_11; pfam13414 643867003524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003525 TPR motif; other site 643867003526 binding surface 643867003527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003528 TPR motif; other site 643867003529 binding surface 643867003530 Tetratricopeptide repeat; Region: TPR_9; pfam13371 643867003531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003532 binding surface 643867003533 TPR motif; other site 643867003534 Helix-turn-helix domain; Region: HTH_18; pfam12833 643867003535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 643867003536 AAA domain; Region: AAA_33; pfam13671 643867003537 AAA domain; Region: AAA_17; pfam13207 643867003538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 643867003539 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 643867003540 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 643867003541 hydrophobic ligand binding site; other site 643867003542 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 643867003543 B12-binding domain/radical SAM domain protein, Ta0216 family; Region: B12_SAM_Ta0216; TIGR04190 643867003544 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867003545 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867003546 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867003547 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 643867003548 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 643867003549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003550 TPR repeat; Region: TPR_11; pfam13414 643867003551 binding surface 643867003552 TPR motif; other site 643867003553 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 643867003554 Beta-lactamase; Region: Beta-lactamase; pfam00144 643867003555 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 643867003556 Tetratricopeptide repeat; Region: TPR_16; pfam13432 643867003557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003558 TPR motif; other site 643867003559 CAAX protease self-immunity; Region: Abi; pfam02517 643867003560 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 643867003561 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 643867003562 putative NAD(P) binding site [chemical binding]; other site 643867003563 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867003564 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 643867003565 ligand binding site [chemical binding]; other site 643867003566 flexible hinge region; other site 643867003567 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 643867003568 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 643867003569 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867003570 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867003571 DNA binding residues [nucleotide binding] 643867003572 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 643867003573 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 643867003574 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 643867003575 active site 643867003576 metal binding site [ion binding]; metal-binding site 643867003577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867003578 NmrA-like family; Region: NmrA; pfam05368 643867003579 NAD(P) binding site [chemical binding]; other site 643867003580 active site 643867003581 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 643867003582 NADH(P)-binding; Region: NAD_binding_10; pfam13460 643867003583 NAD binding site [chemical binding]; other site 643867003584 substrate binding site [chemical binding]; other site 643867003585 putative active site [active] 643867003586 Predicted transcriptional regulators [Transcription]; Region: COG1733 643867003587 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 643867003588 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 643867003589 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 643867003590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003591 TPR motif; other site 643867003592 binding surface 643867003593 Predicted transcriptional regulators [Transcription]; Region: COG1695 643867003594 Transcriptional regulator PadR-like family; Region: PadR; cl17335 643867003595 PspC domain; Region: PspC; pfam04024 643867003596 PspC domain; Region: PspC; pfam04024 643867003597 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 643867003598 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 643867003599 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 643867003600 Beta-Casp domain; Region: Beta-Casp; smart01027 643867003601 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 643867003602 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 643867003603 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 643867003604 active site residue [active] 643867003605 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 643867003606 active site residue [active] 643867003607 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 643867003608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867003609 active site 643867003610 phosphorylation site [posttranslational modification] 643867003611 intermolecular recognition site; other site 643867003612 dimerization interface [polypeptide binding]; other site 643867003613 LytTr DNA-binding domain; Region: LytTR; smart00850 643867003614 Histidine kinase; Region: His_kinase; pfam06580 643867003615 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 643867003616 Mg2+ binding site [ion binding]; other site 643867003617 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 643867003618 Histidine kinase; Region: HisKA_3; pfam07730 643867003619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867003620 ATP binding site [chemical binding]; other site 643867003621 Mg2+ binding site [ion binding]; other site 643867003622 G-X-G motif; other site 643867003623 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 643867003624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867003625 active site 643867003626 phosphorylation site [posttranslational modification] 643867003627 intermolecular recognition site; other site 643867003628 dimerization interface [polypeptide binding]; other site 643867003629 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 643867003630 DNA binding residues [nucleotide binding] 643867003631 dimerization interface [polypeptide binding]; other site 643867003632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867003633 NADH(P)-binding; Region: NAD_binding_10; pfam13460 643867003634 NAD(P) binding site [chemical binding]; other site 643867003635 active site 643867003636 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 643867003637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867003638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867003639 DNA binding residues [nucleotide binding] 643867003640 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867003641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867003642 binding surface 643867003643 TPR motif; other site 643867003644 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003646 binding surface 643867003647 TPR motif; other site 643867003648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867003650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 643867003651 dimer interface [polypeptide binding]; other site 643867003652 phosphorylation site [posttranslational modification] 643867003653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867003654 ATP binding site [chemical binding]; other site 643867003655 Mg2+ binding site [ion binding]; other site 643867003656 G-X-G motif; other site 643867003657 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 643867003658 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 643867003659 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 643867003660 ABC transporter; Region: ABC_tran_2; pfam12848 643867003661 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 643867003662 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 643867003663 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 643867003664 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867003665 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867003666 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867003667 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867003668 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 643867003669 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 643867003670 RNA/DNA hybrid binding site [nucleotide binding]; other site 643867003671 active site 643867003672 Predicted amidohydrolase [General function prediction only]; Region: COG0388 643867003673 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 643867003674 putative active site [active] 643867003675 catalytic triad [active] 643867003676 putative dimer interface [polypeptide binding]; other site 643867003677 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 643867003678 EamA-like transporter family; Region: EamA; pfam00892 643867003679 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 643867003680 active site 643867003681 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 643867003682 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867003683 ATP binding site [chemical binding]; other site 643867003684 putative Mg++ binding site [ion binding]; other site 643867003685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867003686 nucleotide binding region [chemical binding]; other site 643867003687 ATP-binding site [chemical binding]; other site 643867003688 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 643867003689 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 643867003690 enoyl-CoA hydratase; Provisional; Region: PRK05995 643867003691 substrate binding site [chemical binding]; other site 643867003692 oxyanion hole (OAH) forming residues; other site 643867003693 trimer interface [polypeptide binding]; other site 643867003694 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 643867003695 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 643867003696 Competence protein; Region: Competence; pfam03772 643867003697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 643867003698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 643867003699 Coenzyme A binding pocket [chemical binding]; other site 643867003700 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 643867003701 PhoH-like protein; Region: PhoH; pfam02562 643867003702 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 643867003703 acyl-coenzyme A oxidase; Region: PLN02636 643867003704 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 643867003705 active site 643867003706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003707 TPR motif; other site 643867003708 binding surface 643867003709 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 643867003710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003711 binding surface 643867003712 TPR motif; other site 643867003713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003714 binding surface 643867003715 TPR motif; other site 643867003716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003717 binding surface 643867003718 TPR motif; other site 643867003719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003720 binding surface 643867003721 TPR motif; other site 643867003722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003723 binding surface 643867003724 TPR motif; other site 643867003725 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003726 binding surface 643867003727 TPR motif; other site 643867003728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003729 binding surface 643867003730 TPR motif; other site 643867003731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003732 binding surface 643867003733 TPR motif; other site 643867003734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003735 binding surface 643867003736 TPR motif; other site 643867003737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003738 binding surface 643867003739 TPR motif; other site 643867003740 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003741 binding surface 643867003742 TPR motif; other site 643867003743 TPR repeat; Region: TPR_11; pfam13414 643867003744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003745 binding surface 643867003746 TPR motif; other site 643867003747 TPR repeat; Region: TPR_11; pfam13414 643867003748 TPR repeat; Region: TPR_11; pfam13414 643867003749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003750 binding surface 643867003751 TPR motif; other site 643867003752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003753 binding surface 643867003754 TPR motif; other site 643867003755 TPR repeat; Region: TPR_11; pfam13414 643867003756 TPR repeat; Region: TPR_11; pfam13414 643867003757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003758 binding surface 643867003759 TPR motif; other site 643867003760 TPR repeat; Region: TPR_11; pfam13414 643867003761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003762 binding surface 643867003763 TPR motif; other site 643867003764 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 643867003765 catalytic nucleophile [active] 643867003766 Fatty acid desaturase; Region: FA_desaturase; pfam00487 643867003767 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 643867003768 putative di-iron ligands [ion binding]; other site 643867003769 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 643867003770 putative uracil binding site [chemical binding]; other site 643867003771 putative active site [active] 643867003772 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 643867003773 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 643867003774 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 643867003775 Walker A/P-loop; other site 643867003776 ATP binding site [chemical binding]; other site 643867003777 Q-loop/lid; other site 643867003778 ABC transporter signature motif; other site 643867003779 Walker B; other site 643867003780 D-loop; other site 643867003781 H-loop/switch region; other site 643867003782 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 643867003783 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 643867003784 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 643867003785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867003786 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867003787 DNA binding residues [nucleotide binding] 643867003788 Pirin-related protein [General function prediction only]; Region: COG1741 643867003789 Pirin; Region: Pirin; pfam02678 643867003790 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 643867003791 MarR family; Region: MarR_2; pfam12802 643867003792 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 643867003793 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 643867003794 FMN binding site [chemical binding]; other site 643867003795 active site 643867003796 substrate binding site [chemical binding]; other site 643867003797 catalytic residue [active] 643867003798 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 643867003799 FRG domain; Region: FRG; pfam08867 643867003800 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 643867003801 HsdM N-terminal domain; Region: HsdM_N; pfam12161 643867003802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867003803 S-adenosylmethionine binding site [chemical binding]; other site 643867003804 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 643867003805 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 643867003806 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 643867003807 Protein of unknown function DUF262; Region: DUF262; pfam03235 643867003808 Uncharacterized conserved protein [Function unknown]; Region: COG3472 643867003809 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 643867003810 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 643867003811 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 643867003812 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867003813 ATP binding site [chemical binding]; other site 643867003814 putative Mg++ binding site [ion binding]; other site 643867003815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 643867003816 nucleotide binding region [chemical binding]; other site 643867003817 ATP-binding site [chemical binding]; other site 643867003818 Helix-turn-helix domain; Region: HTH_19; pfam12844 643867003819 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 643867003820 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 643867003821 catalytic residues [active] 643867003822 catalytic nucleophile [active] 643867003823 Presynaptic Site I dimer interface [polypeptide binding]; other site 643867003824 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 643867003825 Synaptic Flat tetramer interface [polypeptide binding]; other site 643867003826 Synaptic Site I dimer interface [polypeptide binding]; other site 643867003827 DNA binding site [nucleotide binding] 643867003828 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 643867003829 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 643867003830 active site 643867003831 DNA binding site [nucleotide binding] 643867003832 Int/Topo IB signature motif; other site 643867003833 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 643867003834 active site 643867003835 intersubunit interactions; other site 643867003836 catalytic residue [active] 643867003837 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 643867003838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867003839 Walker A/P-loop; other site 643867003840 ATP binding site [chemical binding]; other site 643867003841 Q-loop/lid; other site 643867003842 ABC transporter signature motif; other site 643867003843 Walker B; other site 643867003844 D-loop; other site 643867003845 H-loop/switch region; other site 643867003846 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 643867003847 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 643867003848 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 643867003849 Leucine-rich repeats; other site 643867003850 Substrate binding site [chemical binding]; other site 643867003851 Leucine rich repeat; Region: LRR_8; pfam13855 643867003852 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867003853 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867003854 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 643867003855 active site 643867003856 catalytic motif [active] 643867003857 Zn binding site [ion binding]; other site 643867003858 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 643867003859 intersubunit interface [polypeptide binding]; other site 643867003860 active site 643867003861 catalytic residue [active] 643867003862 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 643867003863 catalytic motif [active] 643867003864 Catalytic residue [active] 643867003865 Aspartyl protease; Region: Asp_protease_2; pfam13650 643867003866 inhibitor binding site; inhibition site 643867003867 catalytic motif [active] 643867003868 Catalytic residue [active] 643867003869 Active site flap [active] 643867003870 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 643867003871 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 643867003872 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 643867003873 putative NAD(P) binding site [chemical binding]; other site 643867003874 putative active site [active] 643867003875 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 643867003876 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 643867003877 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 643867003878 Sulfate transporter family; Region: Sulfate_transp; pfam00916 643867003879 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 643867003880 active site clefts [active] 643867003881 zinc binding site [ion binding]; other site 643867003882 dimer interface [polypeptide binding]; other site 643867003883 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 643867003884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867003885 S-adenosylmethionine binding site [chemical binding]; other site 643867003886 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 643867003887 cofactor binding site; other site 643867003888 metal binding site [ion binding]; metal-binding site 643867003889 DNA polymerase III subunit beta; Validated; Region: PRK05643 643867003890 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 643867003891 putative DNA binding surface [nucleotide binding]; other site 643867003892 dimer interface [polypeptide binding]; other site 643867003893 beta-clamp/clamp loader binding surface; other site 643867003894 beta-clamp/translesion DNA polymerase binding surface; other site 643867003895 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 643867003896 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 643867003897 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 643867003898 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 643867003899 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 643867003900 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 643867003901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867003902 Walker A/P-loop; other site 643867003903 ATP binding site [chemical binding]; other site 643867003904 Q-loop/lid; other site 643867003905 ABC transporter signature motif; other site 643867003906 Walker B; other site 643867003907 D-loop; other site 643867003908 H-loop/switch region; other site 643867003909 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 643867003910 Peptidase family M50; Region: Peptidase_M50; pfam02163 643867003911 active site 643867003912 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 643867003913 putative substrate binding region [chemical binding]; other site 643867003914 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 643867003915 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 643867003916 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 643867003917 amidase catalytic site [active] 643867003918 Zn binding residues [ion binding]; other site 643867003919 substrate binding site [chemical binding]; other site 643867003920 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867003921 Family description; Region: VCBS; pfam13517 643867003922 Immunoglobulin like; Region: IG_like; smart00410 643867003923 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867003924 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003925 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867003928 TPR motif; other site 643867003929 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003930 binding surface 643867003931 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867003932 CHAT domain; Region: CHAT; pfam12770 643867003933 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 643867003934 DHH family; Region: DHH; pfam01368 643867003935 DHHA1 domain; Region: DHHA1; pfam02272 643867003936 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 643867003937 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 643867003938 Walker A/P-loop; other site 643867003939 ATP binding site [chemical binding]; other site 643867003940 Q-loop/lid; other site 643867003941 ABC transporter signature motif; other site 643867003942 Walker B; other site 643867003943 D-loop; other site 643867003944 H-loop/switch region; other site 643867003945 GH3 auxin-responsive promoter; Region: GH3; pfam03321 643867003946 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867003947 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 643867003948 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867003949 putative catalytic residue [active] 643867003950 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 643867003951 catalytic residues [active] 643867003952 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867003953 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 643867003954 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 643867003955 RNA binding surface [nucleotide binding]; other site 643867003956 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 643867003957 active site 643867003958 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 643867003959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 643867003960 active site 643867003961 motif I; other site 643867003962 motif II; other site 643867003963 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 643867003964 active site 643867003965 TraB family; Region: TraB; pfam01963 643867003966 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 643867003967 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867003968 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867003969 DNA binding residues [nucleotide binding] 643867003970 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 643867003971 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 643867003972 putative metal binding site [ion binding]; other site 643867003973 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 643867003974 ScpA/B protein; Region: ScpA_ScpB; cl00598 643867003975 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 643867003976 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 643867003977 TPP-binding site; other site 643867003978 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 643867003979 PYR/PP interface [polypeptide binding]; other site 643867003980 dimer interface [polypeptide binding]; other site 643867003981 TPP binding site [chemical binding]; other site 643867003982 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 643867003983 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 643867003984 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 643867003985 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 643867003986 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 643867003987 NAD binding site [chemical binding]; other site 643867003988 homodimer interface [polypeptide binding]; other site 643867003989 active site 643867003990 substrate binding site [chemical binding]; other site 643867003991 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 643867003992 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 643867003993 NAD binding site [chemical binding]; other site 643867003994 putative substrate binding site 2 [chemical binding]; other site 643867003995 putative substrate binding site 1 [chemical binding]; other site 643867003996 active site 643867003997 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 643867003998 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 643867003999 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 643867004000 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 643867004001 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867004002 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867004003 Transcriptional regulators [Transcription]; Region: MarR; COG1846 643867004004 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 643867004005 beta-carotene hydroxylase; Region: PLN02601 643867004006 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 643867004007 LytB protein; Region: LYTB; cl00507 643867004008 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 643867004009 active site lid residues [active] 643867004010 substrate binding pocket [chemical binding]; other site 643867004011 catalytic residues [active] 643867004012 substrate-Mg2+ binding site; other site 643867004013 aspartate-rich region 1; other site 643867004014 aspartate-rich region 2; other site 643867004015 phytoene desaturase; Region: crtI_fam; TIGR02734 643867004016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 643867004017 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 643867004018 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867004019 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867004020 DNA binding residues [nucleotide binding] 643867004021 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 643867004022 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 643867004023 DNA binding residues [nucleotide binding] 643867004024 B12 binding domain; Region: B12-binding_2; pfam02607 643867004025 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 643867004026 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 643867004027 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 643867004028 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867004029 catalytic residues [active] 643867004030 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 643867004031 metal-binding site [ion binding] 643867004032 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 643867004033 active site residue [active] 643867004034 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 643867004035 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 643867004036 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 643867004037 Peptidase family M28; Region: Peptidase_M28; pfam04389 643867004038 metal binding site [ion binding]; metal-binding site 643867004039 bile acid transporter; Region: bass; TIGR00841 643867004040 Sodium Bile acid symporter family; Region: SBF; cl17470 643867004041 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 643867004042 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 643867004043 quinone interaction residues [chemical binding]; other site 643867004044 active site 643867004045 catalytic residues [active] 643867004046 FMN binding site [chemical binding]; other site 643867004047 substrate binding site [chemical binding]; other site 643867004048 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 643867004049 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 643867004050 Protein of unknown function DUF58; Region: DUF58; pfam01882 643867004051 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 643867004052 metal ion-dependent adhesion site (MIDAS); other site 643867004053 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 643867004054 Lumazine binding domain; Region: Lum_binding; pfam00677 643867004055 Lumazine binding domain; Region: Lum_binding; pfam00677 643867004056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867004057 Response regulator receiver domain; Region: Response_reg; pfam00072 643867004058 active site 643867004059 phosphorylation site [posttranslational modification] 643867004060 intermolecular recognition site; other site 643867004061 dimerization interface [polypeptide binding]; other site 643867004062 LytTr DNA-binding domain; Region: LytTR; smart00850 643867004063 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 643867004064 active site 643867004065 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 643867004066 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 643867004067 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 643867004068 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 643867004069 GAF domain; Region: GAF_2; pfam13185 643867004070 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 643867004071 catalytic motif [active] 643867004072 Zn binding site [ion binding]; other site 643867004073 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 643867004074 RibD C-terminal domain; Region: RibD_C; pfam01872 643867004075 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 643867004076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867004077 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 643867004078 Domain of unknown function DUF20; Region: UPF0118; pfam01594 643867004079 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 643867004080 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 643867004081 Domain of unknown function DUF20; Region: UPF0118; pfam01594 643867004082 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 643867004083 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 643867004084 active site 643867004085 catalytic tetrad [active] 643867004086 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 643867004087 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 643867004088 trmE is a tRNA modification GTPase; Region: trmE; cd04164 643867004089 G1 box; other site 643867004090 GTP/Mg2+ binding site [chemical binding]; other site 643867004091 Switch I region; other site 643867004092 G2 box; other site 643867004093 Switch II region; other site 643867004094 G3 box; other site 643867004095 G4 box; other site 643867004096 G5 box; other site 643867004097 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 643867004098 Sensors of blue-light using FAD; Region: BLUF; pfam04940 643867004099 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 643867004100 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 643867004101 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 643867004102 Rhomboid family; Region: Rhomboid; cl11446 643867004103 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 643867004104 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 643867004105 substrate binding pocket [chemical binding]; other site 643867004106 chain length determination region; other site 643867004107 substrate-Mg2+ binding site; other site 643867004108 catalytic residues [active] 643867004109 aspartate-rich region 1; other site 643867004110 active site lid residues [active] 643867004111 aspartate-rich region 2; other site 643867004112 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 643867004113 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 643867004114 dimer interface [polypeptide binding]; other site 643867004115 decamer (pentamer of dimers) interface [polypeptide binding]; other site 643867004116 catalytic triad [active] 643867004117 peroxidatic and resolving cysteines [active] 643867004118 MgtC family; Region: MgtC; pfam02308 643867004119 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 643867004120 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 643867004121 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 643867004122 active site 643867004123 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 643867004124 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_12; cd13142 643867004125 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 643867004126 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 643867004127 dimer interface [polypeptide binding]; other site 643867004128 motif 1; other site 643867004129 active site 643867004130 motif 2; other site 643867004131 motif 3; other site 643867004132 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 643867004133 anticodon binding site; other site 643867004134 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 643867004135 active sites [active] 643867004136 tetramer interface [polypeptide binding]; other site 643867004137 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 643867004138 hypothetical protein; Validated; Region: PRK00153 643867004139 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 643867004140 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 643867004141 Probable Catalytic site; other site 643867004142 metal-binding site 643867004143 Beta-lactamase; Region: Beta-lactamase; pfam00144 643867004144 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 643867004145 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 643867004146 active site 643867004147 catalytic triad [active] 643867004148 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 643867004149 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867004150 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 643867004151 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867004152 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867004153 Amidohydrolase; Region: Amidohydro_4; pfam13147 643867004154 active site 643867004155 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 643867004156 ribonuclease Z; Region: RNase_Z; TIGR02651 643867004157 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 643867004158 anti sigma factor interaction site; other site 643867004159 regulatory phosphorylation site [posttranslational modification]; other site 643867004160 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 643867004161 ATP binding site [chemical binding]; other site 643867004162 active site 643867004163 substrate binding site [chemical binding]; other site 643867004164 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 643867004165 Coenzyme A binding pocket [chemical binding]; other site 643867004166 argininosuccinate synthase; Provisional; Region: PRK13820 643867004167 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 643867004168 Ligand Binding Site [chemical binding]; other site 643867004169 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 643867004170 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 643867004171 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 643867004172 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 643867004173 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 643867004174 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 643867004175 nucleotide binding site [chemical binding]; other site 643867004176 N-acetyl-L-glutamate binding site [chemical binding]; other site 643867004177 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 643867004178 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 643867004179 metal binding site [ion binding]; metal-binding site 643867004180 dimer interface [polypeptide binding]; other site 643867004181 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 643867004182 Lyase; Region: Lyase_1; pfam00206 643867004183 active sites [active] 643867004184 tetramer interface [polypeptide binding]; other site 643867004185 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 643867004186 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867004187 catalytic residues [active] 643867004188 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 643867004189 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 643867004190 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 643867004191 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 643867004192 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 643867004193 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 643867004194 lipoyl-biotinyl attachment site [posttranslational modification]; other site 643867004195 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867004196 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 643867004197 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 643867004198 four helix bundle protein; Region: TIGR02436 643867004199 Outer membrane efflux protein; Region: OEP; pfam02321 643867004200 Outer membrane efflux protein; Region: OEP; pfam02321 643867004201 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 643867004202 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 643867004203 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 643867004204 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867004205 catalytic triad [active] 643867004206 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 643867004207 putative recombination protein RecB; Provisional; Region: PRK13909 643867004208 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 643867004209 Protein of unknown function (DUF502); Region: DUF502; cl01107 643867004210 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 643867004211 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 643867004212 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 643867004213 FMN-binding domain; Region: FMN_bind; cl01081 643867004214 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 643867004215 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 643867004216 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 643867004217 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 643867004218 LytB protein; Region: LYTB; cl00507 643867004219 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 643867004220 cytidylate kinase; Provisional; Region: cmk; PRK00023 643867004221 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 643867004222 CMP-binding site; other site 643867004223 The sites determining sugar specificity; other site 643867004224 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 643867004225 CHD5-like protein; Region: CHD5; pfam04420 643867004226 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 643867004227 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 643867004228 Surface antigen; Region: Bac_surface_Ag; pfam01103 643867004229 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 643867004230 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 643867004231 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867004232 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 643867004233 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867004234 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 643867004235 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 643867004236 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 643867004237 ABC1 family; Region: ABC1; cl17513 643867004238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867004239 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 643867004240 catalytic nucleophile [active] 643867004241 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 643867004242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867004243 putative substrate translocation pore; other site 643867004244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867004245 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 643867004246 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 643867004247 active site 643867004248 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867004249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867004250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867004251 ATP binding site [chemical binding]; other site 643867004252 Mg2+ binding site [ion binding]; other site 643867004253 G-X-G motif; other site 643867004254 glutamate racemase; Provisional; Region: PRK00865 643867004255 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 643867004256 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 643867004257 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 643867004258 dimer interface [polypeptide binding]; other site 643867004259 substrate binding site [chemical binding]; other site 643867004260 metal binding site [ion binding]; metal-binding site 643867004261 thiamine monophosphate kinase; Provisional; Region: PRK05731 643867004262 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 643867004263 ATP binding site [chemical binding]; other site 643867004264 dimerization interface [polypeptide binding]; other site 643867004265 Maf-like protein; Region: Maf; pfam02545 643867004266 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 643867004267 active site 643867004268 dimer interface [polypeptide binding]; other site 643867004269 Uncharacterized conserved protein [Function unknown]; Region: COG4198 643867004270 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 643867004271 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 643867004272 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 643867004273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867004274 catalytic residue [active] 643867004275 methionine aminotransferase; Validated; Region: PRK09082 643867004276 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 643867004277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867004278 homodimer interface [polypeptide binding]; other site 643867004279 catalytic residue [active] 643867004280 C-N hydrolase family amidase; Provisional; Region: PRK10438 643867004281 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 643867004282 putative active site [active] 643867004283 catalytic triad [active] 643867004284 dimer interface [polypeptide binding]; other site 643867004285 multimer interface [polypeptide binding]; other site 643867004286 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 643867004287 Fasciclin domain; Region: Fasciclin; pfam02469 643867004288 Family description; Region: VCBS; pfam13517 643867004289 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867004290 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 643867004291 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 643867004292 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 643867004293 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 643867004294 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 643867004295 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 643867004296 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 643867004297 GIY-YIG motif/motif A; other site 643867004298 putative active site [active] 643867004299 putative metal binding site [ion binding]; other site 643867004300 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 643867004301 GIY-YIG motif/motif A; other site 643867004302 putative active site [active] 643867004303 putative metal binding site [ion binding]; other site 643867004304 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 643867004305 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 643867004306 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 643867004307 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 643867004308 active site 643867004309 Zn binding site [ion binding]; other site 643867004310 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 643867004311 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 643867004312 FAD binding pocket [chemical binding]; other site 643867004313 FAD binding motif [chemical binding]; other site 643867004314 phosphate binding motif [ion binding]; other site 643867004315 beta-alpha-beta structure motif; other site 643867004316 NAD(p) ribose binding residues [chemical binding]; other site 643867004317 NAD binding pocket [chemical binding]; other site 643867004318 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 643867004319 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 643867004320 catalytic loop [active] 643867004321 iron binding site [ion binding]; other site 643867004322 tellurium resistance terB-like protein; Region: terB_like; cl11965 643867004323 metal binding site [ion binding]; metal-binding site 643867004324 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 643867004325 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 643867004326 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 643867004327 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 643867004328 Na binding site [ion binding]; other site 643867004329 Protein of unknown function (DUF962); Region: DUF962; pfam06127 643867004330 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 643867004331 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 643867004332 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 643867004333 dimer interface [polypeptide binding]; other site 643867004334 allosteric magnesium binding site [ion binding]; other site 643867004335 active site 643867004336 aspartate-rich active site metal binding site; other site 643867004337 Schiff base residues; other site 643867004338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 643867004339 active site 643867004340 motif I; other site 643867004341 motif II; other site 643867004342 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 643867004343 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 643867004344 substrate binding pocket [chemical binding]; other site 643867004345 membrane-bound complex binding site; other site 643867004346 hinge residues; other site 643867004347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867004348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867004349 dimer interface [polypeptide binding]; other site 643867004350 phosphorylation site [posttranslational modification] 643867004351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867004352 ATP binding site [chemical binding]; other site 643867004353 Mg2+ binding site [ion binding]; other site 643867004354 G-X-G motif; other site 643867004355 GAF domain; Region: GAF_2; pfam13185 643867004356 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 643867004357 30S subunit binding site; other site 643867004358 Protein of unknown function DUF86; Region: DUF86; cl01031 643867004359 ferric uptake regulator; Provisional; Region: fur; PRK09462 643867004360 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 643867004361 metal binding site 2 [ion binding]; metal-binding site 643867004362 putative DNA binding helix; other site 643867004363 metal binding site 1 [ion binding]; metal-binding site 643867004364 dimer interface [polypeptide binding]; other site 643867004365 structural Zn2+ binding site [ion binding]; other site 643867004366 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 643867004367 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 643867004368 Heavy-metal-associated domain; Region: HMA; pfam00403 643867004369 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 643867004370 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 643867004371 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 643867004372 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 643867004373 Low-spin heme binding site [chemical binding]; other site 643867004374 Putative water exit pathway; other site 643867004375 Binuclear center (active site) [active] 643867004376 Putative proton exit pathway; other site 643867004377 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 643867004378 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 643867004379 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 643867004380 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 643867004381 4Fe-4S binding domain; Region: Fer4_5; pfam12801 643867004382 4Fe-4S binding domain; Region: Fer4; pfam00037 643867004383 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 643867004384 FixH; Region: FixH; pfam05751 643867004385 Family description; Region: DsbD_2; pfam13386 643867004386 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 643867004387 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 643867004388 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 643867004389 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 643867004390 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 643867004391 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 643867004392 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 643867004393 Zn binding site [ion binding]; other site 643867004394 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 643867004395 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 643867004396 Walker A/P-loop; other site 643867004397 ATP binding site [chemical binding]; other site 643867004398 Q-loop/lid; other site 643867004399 ABC transporter signature motif; other site 643867004400 Walker B; other site 643867004401 D-loop; other site 643867004402 H-loop/switch region; other site 643867004403 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867004404 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 643867004405 tetramerization interface [polypeptide binding]; other site 643867004406 substrate binding pocket [chemical binding]; other site 643867004407 catalytic residues [active] 643867004408 inhibitor binding sites; inhibition site 643867004409 NADP(H) binding site [chemical binding]; other site 643867004410 prenyltransferase; Provisional; Region: ubiA; PRK13592 643867004411 UbiA prenyltransferase family; Region: UbiA; pfam01040 643867004412 phosphoenolpyruvate synthase; Validated; Region: PRK06241 643867004413 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 643867004414 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 643867004415 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 643867004416 peptide synthase; Provisional; Region: PRK09274 643867004417 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 643867004418 acyl-activating enzyme (AAE) consensus motif; other site 643867004419 AMP binding site [chemical binding]; other site 643867004420 active site 643867004421 CoA binding site [chemical binding]; other site 643867004422 Uncharacterized protein family (UPF0370); Region: UPF0370; cl10119 643867004423 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 643867004424 threonine dehydratase; Validated; Region: PRK08639 643867004425 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 643867004426 tetramer interface [polypeptide binding]; other site 643867004427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867004428 catalytic residue [active] 643867004429 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 643867004430 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 643867004431 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 643867004432 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 643867004433 acetolactate synthase, small subunit; Region: acolac_sm; TIGR00119 643867004434 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 643867004435 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 643867004436 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 643867004437 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 643867004438 PYR/PP interface [polypeptide binding]; other site 643867004439 dimer interface [polypeptide binding]; other site 643867004440 TPP binding site [chemical binding]; other site 643867004441 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 643867004442 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 643867004443 TPP-binding site [chemical binding]; other site 643867004444 dimer interface [polypeptide binding]; other site 643867004445 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 643867004446 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 643867004447 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 643867004448 homodimer interface [polypeptide binding]; other site 643867004449 substrate-cofactor binding pocket; other site 643867004450 catalytic residue [active] 643867004451 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 643867004452 tartrate dehydrogenase; Region: TTC; TIGR02089 643867004453 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 643867004454 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 643867004455 substrate binding site [chemical binding]; other site 643867004456 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 643867004457 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 643867004458 substrate binding site [chemical binding]; other site 643867004459 ligand binding site [chemical binding]; other site 643867004460 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 643867004461 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 643867004462 active site 643867004463 catalytic residues [active] 643867004464 metal binding site [ion binding]; metal-binding site 643867004465 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 643867004466 heme-binding site [chemical binding]; other site 643867004467 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 643867004468 HemN C-terminal domain; Region: HemN_C; pfam06969 643867004469 hypothetical protein; Provisional; Region: PRK12378 643867004470 Fasciclin domain; Region: Fasciclin; pfam02469 643867004471 Protein of unknown function (DUF983); Region: DUF983; cl02211 643867004472 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 643867004473 isocitrate dehydrogenase; Validated; Region: PRK09222 643867004474 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 643867004475 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 643867004476 NAD binding site [chemical binding]; other site 643867004477 substrate binding site [chemical binding]; other site 643867004478 homodimer interface [polypeptide binding]; other site 643867004479 active site 643867004480 GH3 auxin-responsive promoter; Region: GH3; pfam03321 643867004481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 643867004482 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 643867004483 active site 643867004484 motif I; other site 643867004485 motif II; other site 643867004486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 643867004487 SEC-C motif; Region: SEC-C; pfam02810 643867004488 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 643867004489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 643867004490 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 643867004491 dimerization interface [polypeptide binding]; other site 643867004492 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 643867004493 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 643867004494 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 643867004495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 643867004496 dimer interface [polypeptide binding]; other site 643867004497 conserved gate region; other site 643867004498 putative PBP binding loops; other site 643867004499 ABC-ATPase subunit interface; other site 643867004500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 643867004501 dimer interface [polypeptide binding]; other site 643867004502 conserved gate region; other site 643867004503 putative PBP binding loops; other site 643867004504 ABC-ATPase subunit interface; other site 643867004505 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 643867004506 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 643867004507 Walker A/P-loop; other site 643867004508 ATP binding site [chemical binding]; other site 643867004509 Q-loop/lid; other site 643867004510 ABC transporter signature motif; other site 643867004511 Walker B; other site 643867004512 D-loop; other site 643867004513 H-loop/switch region; other site 643867004514 TOBE domain; Region: TOBE_2; pfam08402 643867004515 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 643867004516 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867004517 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867004518 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867004519 GLPGLI family protein; Region: GLPGLI; TIGR01200 643867004520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867004521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867004522 dimer interface [polypeptide binding]; other site 643867004523 phosphorylation site [posttranslational modification] 643867004524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867004525 ATP binding site [chemical binding]; other site 643867004526 Mg2+ binding site [ion binding]; other site 643867004527 G-X-G motif; other site 643867004528 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 643867004529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867004530 active site 643867004531 phosphorylation site [posttranslational modification] 643867004532 intermolecular recognition site; other site 643867004533 dimerization interface [polypeptide binding]; other site 643867004534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 643867004535 DNA binding site [nucleotide binding] 643867004536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867004537 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 643867004538 putative substrate translocation pore; other site 643867004539 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 643867004540 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 643867004541 Glycoprotease family; Region: Peptidase_M22; pfam00814 643867004542 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 643867004543 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 643867004544 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 643867004545 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 643867004546 protein binding site [polypeptide binding]; other site 643867004547 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 643867004548 Catalytic dyad [active] 643867004549 ribonuclease P; Reviewed; Region: rnpA; PRK01903 643867004550 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 643867004551 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 643867004552 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 643867004553 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 643867004554 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 643867004555 Peptidase family M48; Region: Peptidase_M48; cl12018 643867004556 Tic20-like protein; Region: Tic20; pfam09685 643867004557 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 643867004558 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 643867004559 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 643867004560 active site 643867004561 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 643867004562 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 643867004563 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 643867004564 dimer interface [polypeptide binding]; other site 643867004565 active site 643867004566 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 643867004567 four helix bundle protein; Region: TIGR02436 643867004568 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 643867004569 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 643867004570 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 643867004571 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 643867004572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 643867004573 substrate binding site [chemical binding]; other site 643867004574 oxyanion hole (OAH) forming residues; other site 643867004575 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 643867004576 MarR family; Region: MarR; pfam01047 643867004577 MarR family; Region: MarR_2; cl17246 643867004578 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 643867004579 proposed catalytic triad [active] 643867004580 active site nucleophile [active] 643867004581 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 643867004582 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 643867004583 catalytic loop [active] 643867004584 iron binding site [ion binding]; other site 643867004585 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 643867004586 FAD binding pocket [chemical binding]; other site 643867004587 FAD binding motif [chemical binding]; other site 643867004588 phosphate binding motif [ion binding]; other site 643867004589 beta-alpha-beta structure motif; other site 643867004590 NAD binding pocket [chemical binding]; other site 643867004591 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 643867004592 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 643867004593 FeS/SAM binding site; other site 643867004594 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 643867004595 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 643867004596 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 643867004597 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 643867004598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867004599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 643867004600 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 643867004601 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 643867004602 dimer interface [polypeptide binding]; other site 643867004603 active site 643867004604 CoA binding pocket [chemical binding]; other site 643867004605 GTP-binding protein Der; Reviewed; Region: PRK00093 643867004606 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 643867004607 G1 box; other site 643867004608 GTP/Mg2+ binding site [chemical binding]; other site 643867004609 Switch I region; other site 643867004610 G2 box; other site 643867004611 Switch II region; other site 643867004612 G3 box; other site 643867004613 G4 box; other site 643867004614 G5 box; other site 643867004615 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 643867004616 G1 box; other site 643867004617 GTP/Mg2+ binding site [chemical binding]; other site 643867004618 Switch I region; other site 643867004619 G2 box; other site 643867004620 G3 box; other site 643867004621 Switch II region; other site 643867004622 G4 box; other site 643867004623 G5 box; other site 643867004624 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 643867004625 four helix bundle protein; Region: TIGR02436 643867004626 GTPase Era; Reviewed; Region: era; PRK00089 643867004627 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 643867004628 G1 box; other site 643867004629 GTP/Mg2+ binding site [chemical binding]; other site 643867004630 Switch I region; other site 643867004631 G2 box; other site 643867004632 Switch II region; other site 643867004633 G3 box; other site 643867004634 G4 box; other site 643867004635 G5 box; other site 643867004636 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 643867004637 GIY-YIG motif/motif A; other site 643867004638 putative active site [active] 643867004639 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 643867004640 hydrophobic ligand binding site; other site 643867004641 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 643867004642 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867004643 ligand binding site [chemical binding]; other site 643867004644 flexible hinge region; other site 643867004645 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 643867004646 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 643867004647 active site 643867004648 YceG-like family; Region: YceG; pfam02618 643867004649 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 643867004650 dimerization interface [polypeptide binding]; other site 643867004651 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 643867004652 WbqC-like protein family; Region: WbqC; pfam08889 643867004653 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 643867004654 Clp amino terminal domain; Region: Clp_N; pfam02861 643867004655 Clp amino terminal domain; Region: Clp_N; pfam02861 643867004656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867004657 Walker A motif; other site 643867004658 ATP binding site [chemical binding]; other site 643867004659 Walker B motif; other site 643867004660 arginine finger; other site 643867004661 UvrB/uvrC motif; Region: UVR; pfam02151 643867004662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867004663 Walker A motif; other site 643867004664 ATP binding site [chemical binding]; other site 643867004665 Walker B motif; other site 643867004666 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 643867004667 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 643867004668 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 643867004669 putative DNA binding site [nucleotide binding]; other site 643867004670 putative Zn2+ binding site [ion binding]; other site 643867004671 AsnC family; Region: AsnC_trans_reg; pfam01037 643867004672 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 643867004673 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 643867004674 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 643867004675 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 643867004676 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 643867004677 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 643867004678 Sodium Bile acid symporter family; Region: SBF; pfam01758 643867004679 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 643867004680 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 643867004681 four helix bundle protein; Region: TIGR02436 643867004682 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867004683 Outer membrane efflux protein; Region: OEP; pfam02321 643867004684 Outer membrane efflux protein; Region: OEP; pfam02321 643867004685 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 643867004686 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 643867004687 ATP-grasp domain; Region: ATP-grasp_4; cl17255 643867004688 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 643867004689 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 643867004690 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 643867004691 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 643867004692 ATP-grasp domain; Region: ATP-grasp_4; cl17255 643867004693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867004694 S-adenosylmethionine binding site [chemical binding]; other site 643867004695 UbiA prenyltransferase family; Region: UbiA; pfam01040 643867004696 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 643867004697 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 643867004698 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 643867004699 RimM N-terminal domain; Region: RimM; pfam01782 643867004700 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 643867004701 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 643867004702 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 643867004703 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 643867004704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867004705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867004706 dimer interface [polypeptide binding]; other site 643867004707 phosphorylation site [posttranslational modification] 643867004708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867004709 ATP binding site [chemical binding]; other site 643867004710 Mg2+ binding site [ion binding]; other site 643867004711 G-X-G motif; other site 643867004712 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 643867004713 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 643867004714 TPP-binding site [chemical binding]; other site 643867004715 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 643867004716 PYR/PP interface [polypeptide binding]; other site 643867004717 dimer interface [polypeptide binding]; other site 643867004718 TPP binding site [chemical binding]; other site 643867004719 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 643867004720 E3 interaction surface; other site 643867004721 lipoyl attachment site [posttranslational modification]; other site 643867004722 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 643867004723 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 643867004724 E3 interaction surface; other site 643867004725 lipoyl attachment site [posttranslational modification]; other site 643867004726 e3 binding domain; Region: E3_binding; pfam02817 643867004727 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 643867004728 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 643867004729 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 643867004730 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 643867004731 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 643867004732 Flagellin N-methylase; Region: FliB; cl00497 643867004733 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 643867004734 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 643867004735 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 643867004736 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 643867004737 active site 643867004738 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 643867004739 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 643867004740 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 643867004741 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 643867004742 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 643867004743 Surface antigen; Region: Bac_surface_Ag; pfam01103 643867004744 hypothetical protein; Provisional; Region: PRK11820 643867004745 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 643867004746 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 643867004747 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 643867004748 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 643867004749 Zn binding site [ion binding]; other site 643867004750 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 643867004751 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 643867004752 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 643867004753 PemK-like protein; Region: PemK; pfam02452 643867004754 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 643867004755 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 643867004756 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 643867004757 metal binding site [ion binding]; metal-binding site 643867004758 dimer interface [polypeptide binding]; other site 643867004759 Sporulation related domain; Region: SPOR; cl10051 643867004760 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 643867004761 DEAD/DEAH box helicase; Region: DEAD; pfam00270 643867004762 ATP binding site [chemical binding]; other site 643867004763 putative Mg++ binding site [ion binding]; other site 643867004764 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 643867004765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867004766 nucleotide binding region [chemical binding]; other site 643867004767 ATP-binding site [chemical binding]; other site 643867004768 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 643867004769 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 643867004770 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 643867004771 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 643867004772 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 643867004773 DNA binding residues [nucleotide binding] 643867004774 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 643867004775 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 643867004776 cofactor binding site; other site 643867004777 DNA binding site [nucleotide binding] 643867004778 substrate interaction site [chemical binding]; other site 643867004779 Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553 643867004780 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 643867004781 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 643867004782 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 643867004783 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 643867004784 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 643867004785 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 643867004786 putative ribose interaction site [chemical binding]; other site 643867004787 putative ADP binding site [chemical binding]; other site 643867004788 aspartate aminotransferase; Provisional; Region: PRK05764 643867004789 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 643867004790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867004791 homodimer interface [polypeptide binding]; other site 643867004792 catalytic residue [active] 643867004793 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 643867004794 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 643867004795 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 643867004796 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 643867004797 Chromate transporter; Region: Chromate_transp; pfam02417 643867004798 Chromate transporter; Region: Chromate_transp; pfam02417 643867004799 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867004800 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 643867004801 dimer interface [polypeptide binding]; other site 643867004802 catalytic triad [active] 643867004803 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 643867004804 periplasmic chaperone; Provisional; Region: PRK10780 643867004805 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 643867004806 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 643867004807 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 643867004808 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 643867004809 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 643867004810 Surface antigen; Region: Bac_surface_Ag; pfam01103 643867004811 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 643867004812 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 643867004813 catalytic residue [active] 643867004814 putative FPP diphosphate binding site; other site 643867004815 putative FPP binding hydrophobic cleft; other site 643867004816 dimer interface [polypeptide binding]; other site 643867004817 putative IPP diphosphate binding site; other site 643867004818 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 643867004819 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 643867004820 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 643867004821 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 643867004822 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 643867004823 Glutamine amidotransferase class-I; Region: GATase; pfam00117 643867004824 glutamine binding [chemical binding]; other site 643867004825 catalytic triad [active] 643867004826 Colicin V production protein; Region: Colicin_V; pfam02674 643867004827 Yqey-like protein; Region: YqeY; pfam09424 643867004828 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 643867004829 active site 643867004830 hydrophilic channel; other site 643867004831 dimerization interface [polypeptide binding]; other site 643867004832 catalytic residues [active] 643867004833 active site lid [active] 643867004834 Transposase; Region: HTH_Tnp_1; pfam01527 643867004835 putative transposase OrfB; Reviewed; Region: PHA02517 643867004836 Integrase core domain; Region: rve; pfam00665 643867004837 Integrase core domain; Region: rve_3; pfam13683 643867004838 acyl-CoA esterase; Provisional; Region: PRK10673 643867004839 PGAP1-like protein; Region: PGAP1; pfam07819 643867004840 Predicted membrane protein [Function unknown]; Region: COG2860 643867004841 UPF0126 domain; Region: UPF0126; pfam03458 643867004842 UPF0126 domain; Region: UPF0126; pfam03458 643867004843 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 643867004844 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 643867004845 substrate binding pocket [chemical binding]; other site 643867004846 membrane-bound complex binding site; other site 643867004847 hinge residues; other site 643867004848 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 643867004849 N-acetyl-D-glucosamine binding site [chemical binding]; other site 643867004850 catalytic residue [active] 643867004851 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 643867004852 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 643867004853 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 643867004854 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 643867004855 active site 643867004856 Transposase; Region: HTH_Tnp_1; pfam01527 643867004857 putative transposase OrfB; Reviewed; Region: PHA02517 643867004858 Integrase core domain; Region: rve; pfam00665 643867004859 Integrase core domain; Region: rve_3; pfam13683 643867004860 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 643867004861 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 643867004862 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 643867004863 putative RNA binding site [nucleotide binding]; other site 643867004864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867004865 S-adenosylmethionine binding site [chemical binding]; other site 643867004866 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 643867004867 putative catalytic site [active] 643867004868 putative metal binding site [ion binding]; other site 643867004869 putative phosphate binding site [ion binding]; other site 643867004870 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 643867004871 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 643867004872 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 643867004873 Predicted peptidase [General function prediction only]; Region: COG4099 643867004874 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 643867004875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 643867004876 Putative glucoamylase; Region: Glycoamylase; pfam10091 643867004877 Bacterial Ig-like domain; Region: Big_5; pfam13205 643867004878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 643867004879 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 643867004880 Putative glucoamylase; Region: Glycoamylase; pfam10091 643867004881 Bacterial Ig-like domain; Region: Big_5; pfam13205 643867004882 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 643867004883 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 643867004884 starch binding outer membrane protein SusD; Region: SusD; cd08977 643867004885 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867004886 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 643867004887 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 643867004888 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 643867004889 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 643867004890 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 643867004891 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 643867004892 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 643867004893 Catalytic domain of Protein Kinases; Region: PKc; cd00180 643867004894 active site 643867004895 ATP binding site [chemical binding]; other site 643867004896 substrate binding site [chemical binding]; other site 643867004897 activation loop (A-loop); other site 643867004898 AAA ATPase domain; Region: AAA_16; pfam13191 643867004899 Predicted ATPase [General function prediction only]; Region: COG3899 643867004900 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867004901 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 643867004902 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 643867004903 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 643867004904 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 643867004905 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 643867004906 putative metal binding site [ion binding]; other site 643867004907 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 643867004908 putative FMN binding site [chemical binding]; other site 643867004909 GxxExxY protein; Region: GxxExxY; TIGR04256 643867004910 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 643867004911 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 643867004912 ATP cone domain; Region: ATP-cone; pfam03477 643867004913 Class I ribonucleotide reductase; Region: RNR_I; cd01679 643867004914 active site 643867004915 dimer interface [polypeptide binding]; other site 643867004916 catalytic residues [active] 643867004917 effector binding site; other site 643867004918 R2 peptide binding site; other site 643867004919 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 643867004920 dimer interface [polypeptide binding]; other site 643867004921 putative radical transfer pathway; other site 643867004922 diiron center [ion binding]; other site 643867004923 tyrosyl radical; other site 643867004924 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 643867004925 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 643867004926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867004927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867004928 binding surface 643867004929 TPR motif; other site 643867004930 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867004931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867004932 binding surface 643867004933 TPR motif; other site 643867004934 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867004935 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867004936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867004937 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 643867004938 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867004939 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 643867004940 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 643867004941 active site 643867004942 (T/H)XGH motif; other site 643867004943 Guanylate kinase; Region: Guanylate_kin; pfam00625 643867004944 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 643867004945 catalytic site [active] 643867004946 G-X2-G-X-G-K; other site 643867004947 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 643867004948 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 643867004949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867004950 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867004951 DNA binding residues [nucleotide binding] 643867004952 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 643867004953 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 643867004954 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867004955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867004956 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 643867004957 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 643867004958 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867004959 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 643867004960 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 643867004961 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 643867004962 active site 643867004963 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 643867004964 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 643867004965 putative metal binding site; other site 643867004966 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 643867004967 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 643867004968 homotetramer interface [polypeptide binding]; other site 643867004969 ligand binding site [chemical binding]; other site 643867004970 catalytic site [active] 643867004971 NAD binding site [chemical binding]; other site 643867004972 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 643867004973 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 643867004974 Oligomerisation domain; Region: Oligomerisation; pfam02410 643867004975 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 643867004976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867004977 Walker A motif; other site 643867004978 ATP binding site [chemical binding]; other site 643867004979 Walker B motif; other site 643867004980 arginine finger; other site 643867004981 Peptidase family M41; Region: Peptidase_M41; pfam01434 643867004982 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 643867004983 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 643867004984 hydrophobic ligand binding site; other site 643867004985 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 643867004986 catalytic core [active] 643867004987 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 643867004988 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 643867004989 substrate binding pocket [chemical binding]; other site 643867004990 membrane-bound complex binding site; other site 643867004991 hinge residues; other site 643867004992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867004993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867004994 dimer interface [polypeptide binding]; other site 643867004995 phosphorylation site [posttranslational modification] 643867004996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867004997 ATP binding site [chemical binding]; other site 643867004998 Mg2+ binding site [ion binding]; other site 643867004999 G-X-G motif; other site 643867005000 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867005001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 643867005002 dimerization interface [polypeptide binding]; other site 643867005003 putative DNA binding site [nucleotide binding]; other site 643867005004 putative Zn2+ binding site [ion binding]; other site 643867005005 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 643867005006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 643867005007 motif II; other site 643867005008 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 643867005009 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 643867005010 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 643867005011 putative active site [active] 643867005012 putative metal binding site [ion binding]; other site 643867005013 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 643867005014 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867005015 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 643867005016 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867005017 acyl carrier protein; Provisional; Region: acpP; PRK00982 643867005018 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 643867005019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867005020 ATP binding site [chemical binding]; other site 643867005021 Mg2+ binding site [ion binding]; other site 643867005022 G-X-G motif; other site 643867005023 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 643867005024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867005025 active site 643867005026 phosphorylation site [posttranslational modification] 643867005027 intermolecular recognition site; other site 643867005028 dimerization interface [polypeptide binding]; other site 643867005029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867005030 Walker A motif; other site 643867005031 ATP binding site [chemical binding]; other site 643867005032 Walker B motif; other site 643867005033 arginine finger; other site 643867005034 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 643867005035 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 643867005036 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 643867005037 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 643867005038 short chain dehydrogenase; Provisional; Region: PRK06181 643867005039 NADP binding site [chemical binding]; other site 643867005040 homodimer interface [polypeptide binding]; other site 643867005041 substrate binding site [chemical binding]; other site 643867005042 active site 643867005043 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 643867005044 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 643867005045 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 643867005046 Sporulation related domain; Region: SPOR; pfam05036 643867005047 GAF domain; Region: GAF_2; pfam13185 643867005048 GAF domain; Region: GAF_3; pfam13492 643867005049 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 643867005050 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 643867005051 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 643867005052 anti sigma factor interaction site; other site 643867005053 regulatory phosphorylation site [posttranslational modification]; other site 643867005054 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 643867005055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 643867005056 ATP binding site [chemical binding]; other site 643867005057 Mg2+ binding site [ion binding]; other site 643867005058 G-X-G motif; other site 643867005059 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 643867005060 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 643867005061 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 643867005062 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 643867005063 SurA N-terminal domain; Region: SurA_N; pfam09312 643867005064 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 643867005065 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 643867005066 MoxR-like ATPases [General function prediction only]; Region: COG0714 643867005067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867005068 Walker A motif; other site 643867005069 ATP binding site [chemical binding]; other site 643867005070 Walker B motif; other site 643867005071 arginine finger; other site 643867005072 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 643867005073 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867005074 catalytic residues [active] 643867005075 Domain of unknown function UPF0086; Region: UPF0086; cl00688 643867005076 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 643867005077 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 643867005078 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 643867005079 nucleotide binding site [chemical binding]; other site 643867005080 NEF interaction site [polypeptide binding]; other site 643867005081 SBD interface [polypeptide binding]; other site 643867005082 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 643867005083 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 643867005084 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 643867005085 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 643867005086 dihydroorotase; Reviewed; Region: PRK09236 643867005087 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867005088 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 643867005089 active site 643867005090 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 643867005091 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 643867005092 ATP binding site [chemical binding]; other site 643867005093 Mg++ binding site [ion binding]; other site 643867005094 motif III; other site 643867005095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867005096 nucleotide binding region [chemical binding]; other site 643867005097 ATP-binding site [chemical binding]; other site 643867005098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867005099 Major Facilitator Superfamily; Region: MFS_1; pfam07690 643867005100 putative substrate translocation pore; other site 643867005101 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 643867005102 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 643867005103 REJ domain; Region: REJ; pfam02010 643867005104 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 643867005105 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 643867005106 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 643867005107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867005108 Walker A/P-loop; other site 643867005109 ATP binding site [chemical binding]; other site 643867005110 Q-loop/lid; other site 643867005111 ABC transporter signature motif; other site 643867005112 Walker B; other site 643867005113 D-loop; other site 643867005114 H-loop/switch region; other site 643867005115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867005116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 643867005117 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 643867005118 classical (c) SDRs; Region: SDR_c; cd05233 643867005119 NAD(P) binding site [chemical binding]; other site 643867005120 active site 643867005121 glutamate dehydrogenase; Provisional; Region: PRK09414 643867005122 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 643867005123 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 643867005124 NAD(P) binding site [chemical binding]; other site 643867005125 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 643867005126 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 643867005127 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 643867005128 Walker A/P-loop; other site 643867005129 ATP binding site [chemical binding]; other site 643867005130 Q-loop/lid; other site 643867005131 ABC transporter signature motif; other site 643867005132 Walker B; other site 643867005133 D-loop; other site 643867005134 H-loop/switch region; other site 643867005135 Erythromycin esterase; Region: Erythro_esteras; cl17110 643867005136 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 643867005137 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867005138 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867005139 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867005140 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 643867005141 putative active site [active] 643867005142 Zn binding site [ion binding]; other site 643867005143 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 643867005144 conserved cys residue [active] 643867005145 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867005146 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867005147 Fasciclin domain; Region: Fasciclin; pfam02469 643867005148 Endonuclease I; Region: Endonuclease_1; pfam04231 643867005149 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 643867005150 generic binding surface II; other site 643867005151 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867005152 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 643867005153 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 643867005154 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867005155 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 643867005156 Outer membrane efflux protein; Region: OEP; pfam02321 643867005157 Outer membrane efflux protein; Region: OEP; pfam02321 643867005158 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867005159 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867005160 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867005161 ligand binding site [chemical binding]; other site 643867005162 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867005163 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867005164 ligand binding site [chemical binding]; other site 643867005165 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 643867005166 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 643867005167 active site 643867005168 nucleophile elbow; other site 643867005169 Surface antigen; Region: Bac_surface_Ag; pfam01103 643867005170 putative peptidase; Provisional; Region: PRK11649 643867005171 Peptidase family M23; Region: Peptidase_M23; pfam01551 643867005172 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 643867005173 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 643867005174 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 643867005175 putative ligand binding site [chemical binding]; other site 643867005176 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 643867005177 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 643867005178 ABC-ATPase subunit interface; other site 643867005179 dimer interface [polypeptide binding]; other site 643867005180 putative PBP binding regions; other site 643867005181 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 643867005182 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 643867005183 Walker A/P-loop; other site 643867005184 ATP binding site [chemical binding]; other site 643867005185 Q-loop/lid; other site 643867005186 ABC transporter signature motif; other site 643867005187 Walker B; other site 643867005188 D-loop; other site 643867005189 H-loop/switch region; other site 643867005190 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 643867005191 metal binding site 2 [ion binding]; metal-binding site 643867005192 putative DNA binding helix; other site 643867005193 metal binding site 1 [ion binding]; metal-binding site 643867005194 dimer interface [polypeptide binding]; other site 643867005195 structural Zn2+ binding site [ion binding]; other site 643867005196 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 643867005197 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 643867005198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867005199 Walker A/P-loop; other site 643867005200 ATP binding site [chemical binding]; other site 643867005201 Q-loop/lid; other site 643867005202 ABC transporter signature motif; other site 643867005203 Walker B; other site 643867005204 D-loop; other site 643867005205 H-loop/switch region; other site 643867005206 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 643867005207 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 643867005208 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 643867005209 NAD binding site [chemical binding]; other site 643867005210 Phe binding site; other site 643867005211 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 643867005212 transcription antitermination factor NusB; Region: nusB; TIGR01951 643867005213 YtxH-like protein; Region: YtxH; cl02079 643867005214 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 643867005215 Preprotein translocase subunit; Region: YajC; pfam02699 643867005216 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 643867005217 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 643867005218 CoA-binding site [chemical binding]; other site 643867005219 ATP-binding [chemical binding]; other site 643867005220 acetyl-CoA synthetase; Provisional; Region: PRK00174 643867005221 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 643867005222 active site 643867005223 CoA binding site [chemical binding]; other site 643867005224 acyl-activating enzyme (AAE) consensus motif; other site 643867005225 AMP binding site [chemical binding]; other site 643867005226 acetate binding site [chemical binding]; other site 643867005227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867005228 binding surface 643867005229 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867005230 TPR motif; other site 643867005231 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867005232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867005233 binding surface 643867005234 TPR motif; other site 643867005235 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 643867005236 Ion channel; Region: Ion_trans_2; pfam07885 643867005237 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 643867005238 TrkA-N domain; Region: TrkA_N; pfam02254 643867005239 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 643867005240 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 643867005241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 643867005242 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 643867005243 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 643867005244 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 643867005245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 643867005246 FeS/SAM binding site; other site 643867005247 TRAM domain; Region: TRAM; cl01282 643867005248 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 643867005249 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 643867005250 substrate binding site [chemical binding]; other site 643867005251 active site 643867005252 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 643867005253 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 643867005254 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 643867005255 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 643867005256 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 643867005257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 643867005258 active site 643867005259 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 643867005260 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 643867005261 M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262 643867005262 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 643867005263 active site 643867005264 adenylate kinase; Reviewed; Region: adk; PRK00279 643867005265 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 643867005266 AMP-binding site [chemical binding]; other site 643867005267 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 643867005268 GTPase CgtA; Reviewed; Region: obgE; PRK12299 643867005269 GTP1/OBG; Region: GTP1_OBG; pfam01018 643867005270 Obg GTPase; Region: Obg; cd01898 643867005271 G1 box; other site 643867005272 GTP/Mg2+ binding site [chemical binding]; other site 643867005273 Switch I region; other site 643867005274 G2 box; other site 643867005275 G3 box; other site 643867005276 Switch II region; other site 643867005277 G4 box; other site 643867005278 G5 box; other site 643867005279 GrpE; Region: GrpE; pfam01025 643867005280 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 643867005281 dimer interface [polypeptide binding]; other site 643867005282 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 643867005283 chaperone protein DnaJ; Provisional; Region: PRK14289 643867005284 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 643867005285 HSP70 interaction site [polypeptide binding]; other site 643867005286 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 643867005287 substrate binding site [polypeptide binding]; other site 643867005288 dimer interface [polypeptide binding]; other site 643867005289 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 643867005290 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 643867005291 active site 643867005292 DNA binding site [nucleotide binding] 643867005293 Int/Topo IB signature motif; other site 643867005294 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 643867005295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867005296 non-specific DNA binding site [nucleotide binding]; other site 643867005297 salt bridge; other site 643867005298 sequence-specific DNA binding site [nucleotide binding]; other site 643867005299 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 643867005300 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 643867005301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867005302 S-adenosylmethionine binding site [chemical binding]; other site 643867005303 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 643867005304 Putative transposase; Region: Y2_Tnp; pfam04986 643867005305 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 643867005306 active site 643867005307 DNA binding site [nucleotide binding] 643867005308 Int/Topo IB signature motif; other site 643867005309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 643867005310 AAA domain; Region: AAA_33; pfam13671 643867005311 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 643867005312 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 643867005313 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 643867005314 Protein of unknown function (DUF433); Region: DUF433; pfam04255 643867005315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 643867005316 GAF domain; Region: GAF; pfam01590 643867005317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867005318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867005319 ATP binding site [chemical binding]; other site 643867005320 Mg2+ binding site [ion binding]; other site 643867005321 G-X-G motif; other site 643867005322 phytoene desaturase; Region: crtI_fam; TIGR02734 643867005323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 643867005324 Protein of unknown function (DUF422); Region: DUF422; cl00991 643867005325 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 643867005326 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867005327 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867005328 trehalose synthase; Region: treS_nterm; TIGR02456 643867005329 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 643867005330 Ca binding site [ion binding]; other site 643867005331 active site 643867005332 catalytic site [active] 643867005333 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867005334 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 643867005335 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 643867005336 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 643867005337 Repair protein; Region: Repair_PSII; pfam04536 643867005338 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867005339 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 643867005340 N-terminal plug; other site 643867005341 ligand-binding site [chemical binding]; other site 643867005342 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 643867005343 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 643867005344 glutathione-disulfide reductase, animal/bacterial; Region: gluta_reduc_1; TIGR01421 643867005345 Pirin-related protein [General function prediction only]; Region: COG1741 643867005346 Pirin; Region: Pirin; pfam02678 643867005347 Tellurite resistance protein TerB; Region: TerB; pfam05099 643867005348 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 643867005349 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 643867005350 Walker A/P-loop; other site 643867005351 ATP binding site [chemical binding]; other site 643867005352 Q-loop/lid; other site 643867005353 ABC transporter signature motif; other site 643867005354 Walker B; other site 643867005355 D-loop; other site 643867005356 H-loop/switch region; other site 643867005357 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 643867005358 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 643867005359 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867005360 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 643867005361 tyrosine decarboxylase; Region: PLN02880 643867005362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867005363 catalytic residue [active] 643867005364 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 643867005365 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 643867005366 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 643867005367 generic binding surface II; other site 643867005368 ssDNA binding site; other site 643867005369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867005370 ATP binding site [chemical binding]; other site 643867005371 putative Mg++ binding site [ion binding]; other site 643867005372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867005373 nucleotide binding region [chemical binding]; other site 643867005374 ATP-binding site [chemical binding]; other site 643867005375 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 643867005376 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 643867005377 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 643867005378 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 643867005379 Protein export membrane protein; Region: SecD_SecF; pfam02355 643867005380 glycine dehydrogenase; Provisional; Region: PRK05367 643867005381 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 643867005382 tetramer interface [polypeptide binding]; other site 643867005383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867005384 catalytic residue [active] 643867005385 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 643867005386 tetramer interface [polypeptide binding]; other site 643867005387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867005388 catalytic residue [active] 643867005389 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 643867005390 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 643867005391 Peptidase family M28; Region: Peptidase_M28; pfam04389 643867005392 metal binding site [ion binding]; metal-binding site 643867005393 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 643867005394 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 643867005395 active site 643867005396 dimerization interface [polypeptide binding]; other site 643867005397 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 643867005398 Predicted methyltransferases [General function prediction only]; Region: COG0313 643867005399 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 643867005400 putative SAM binding site [chemical binding]; other site 643867005401 putative homodimer interface [polypeptide binding]; other site 643867005402 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 643867005403 aromatic arch; other site 643867005404 DCoH dimer interaction site [polypeptide binding]; other site 643867005405 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 643867005406 DCoH tetramer interaction site [polypeptide binding]; other site 643867005407 substrate binding site [chemical binding]; other site 643867005408 Protein of unknown function (DUF493); Region: DUF493; pfam04359 643867005409 SurA N-terminal domain; Region: SurA_N_3; cl07813 643867005410 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 643867005411 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 643867005412 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 643867005413 Domain of unknown function DUF21; Region: DUF21; pfam01595 643867005414 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 643867005415 Transporter associated domain; Region: CorC_HlyC; smart01091 643867005416 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 643867005417 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867005418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867005419 TPR motif; other site 643867005420 binding surface 643867005421 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 643867005422 Type III pantothenate kinase; Region: Pan_kinase; cl17198 643867005423 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 643867005424 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 643867005425 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 643867005426 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 643867005427 NAD(P) binding pocket [chemical binding]; other site 643867005428 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 643867005429 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 643867005430 transmembrane helices; other site 643867005431 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 643867005432 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 643867005433 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 643867005434 GTP binding site [chemical binding]; other site 643867005435 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 643867005436 ribosomal protein L33; Region: rpl33; CHL00104 643867005437 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 643867005438 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 643867005439 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 643867005440 inhibitor-cofactor binding pocket; inhibition site 643867005441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867005442 catalytic residue [active] 643867005443 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 643867005444 dimerization interface [polypeptide binding]; other site 643867005445 ATP binding site [chemical binding]; other site 643867005446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867005447 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 643867005448 putative substrate translocation pore; other site 643867005449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867005450 Predicted membrane protein [Function unknown]; Region: COG1288 643867005451 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 643867005452 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 643867005453 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 643867005454 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867005455 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 643867005456 ligand binding site [chemical binding]; other site 643867005457 flexible hinge region; other site 643867005458 Protein of unknown function (DUF808); Region: DUF808; cl01002 643867005459 Protein of unknown function, DUF399; Region: DUF399; pfam04187 643867005460 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 643867005461 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 643867005462 catalytic residues [active] 643867005463 SprT homologues; Region: SprT; cl01182 643867005464 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 643867005465 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 643867005466 putative active site [active] 643867005467 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 643867005468 nucleotide binding site [chemical binding]; other site 643867005469 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 643867005470 phosphate binding site [ion binding]; other site 643867005471 Helix-turn-helix domain; Region: HTH_18; pfam12833 643867005472 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 643867005473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 643867005474 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 643867005475 FAD binding site [chemical binding]; other site 643867005476 homotetramer interface [polypeptide binding]; other site 643867005477 substrate binding pocket [chemical binding]; other site 643867005478 catalytic base [active] 643867005479 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 643867005480 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 643867005481 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 643867005482 active site 643867005483 nucleotide binding site [chemical binding]; other site 643867005484 HIGH motif; other site 643867005485 KMSKS motif; other site 643867005486 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 643867005487 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 643867005488 tetramerization interface [polypeptide binding]; other site 643867005489 active site 643867005490 Pantoate-beta-alanine ligase; Region: PanC; cd00560 643867005491 pantoate--beta-alanine ligase; Region: panC; TIGR00018 643867005492 active site 643867005493 ATP-binding site [chemical binding]; other site 643867005494 pantoate-binding site; other site 643867005495 HXXH motif; other site 643867005496 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 643867005497 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 643867005498 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 643867005499 glutaminase active site [active] 643867005500 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 643867005501 dimer interface [polypeptide binding]; other site 643867005502 active site 643867005503 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 643867005504 dimer interface [polypeptide binding]; other site 643867005505 active site 643867005506 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 643867005507 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 643867005508 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 643867005509 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 643867005510 metal-binding site [ion binding] 643867005511 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 643867005512 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 643867005513 metal-binding site [ion binding] 643867005514 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 643867005515 Soluble P-type ATPase [General function prediction only]; Region: COG4087 643867005516 Helix-turn-helix domain; Region: HTH_18; pfam12833 643867005517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 643867005518 SnoaL-like domain; Region: SnoaL_3; pfam13474 643867005519 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 643867005520 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 643867005521 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 643867005522 putative active site; other site 643867005523 catalytic residue [active] 643867005524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867005525 Major Facilitator Superfamily; Region: MFS_1; pfam07690 643867005526 putative substrate translocation pore; other site 643867005527 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 643867005528 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 643867005529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 643867005530 motif II; other site 643867005531 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 643867005532 amino acid transporter; Region: 2A0306; TIGR00909 643867005533 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 643867005534 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 643867005535 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 643867005536 active site 643867005537 thymidine phosphorylase; Provisional; Region: PRK04350 643867005538 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 643867005539 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 643867005540 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 643867005541 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 643867005542 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 643867005543 Beta-Casp domain; Region: Beta-Casp; pfam10996 643867005544 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 643867005545 ATP cone domain; Region: ATP-cone; pfam03477 643867005546 Restriction endonuclease; Region: Mrr_cat; pfam04471 643867005547 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 643867005548 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 643867005549 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207 643867005550 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 643867005551 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 643867005552 Ion channel; Region: Ion_trans_2; pfam07885 643867005553 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 643867005554 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 643867005555 putative active site [active] 643867005556 redox center [active] 643867005557 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 643867005558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867005559 NAD(P) binding site [chemical binding]; other site 643867005560 active site 643867005561 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867005562 Ligand Binding Site [chemical binding]; other site 643867005563 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867005564 Ligand Binding Site [chemical binding]; other site 643867005565 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 643867005566 Nitrogen regulatory protein P-II; Region: P-II; smart00938 643867005567 Short C-terminal domain; Region: SHOCT; pfam09851 643867005568 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 643867005569 Domain of unknown function DUF302; Region: DUF302; pfam03625 643867005570 Helix-turn-helix domain; Region: HTH_18; pfam12833 643867005571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 643867005572 multicopper oxidase; Provisional; Region: PRK10965 643867005573 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 643867005574 Multicopper oxidase; Region: Cu-oxidase; pfam00394 643867005575 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 643867005576 amino acid transporter; Region: 2A0306; TIGR00909 643867005577 Predicted membrane protein [Function unknown]; Region: COG3462 643867005578 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 643867005579 active site residue [active] 643867005580 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 643867005581 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 643867005582 Domain of unknown function DUF302; Region: DUF302; cl01364 643867005583 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 643867005584 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 643867005585 Multicopper oxidase; Region: Cu-oxidase; pfam00394 643867005586 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 643867005587 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 643867005588 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 643867005589 Helix-turn-helix domain; Region: HTH_18; pfam12833 643867005590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 643867005591 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 643867005592 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 643867005593 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867005594 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 643867005595 Outer membrane efflux protein; Region: OEP; pfam02321 643867005596 Outer membrane efflux protein; Region: OEP; pfam02321 643867005597 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 643867005598 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 643867005599 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 643867005600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 643867005601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 643867005602 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 643867005603 peptide chain release factor 1; Provisional; Region: PRK04011 643867005604 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 643867005605 metal-binding site [ion binding] 643867005606 MerT mercuric transport protein; Region: MerT; cl03578 643867005607 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 643867005608 metal-binding site [ion binding] 643867005609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 643867005610 dimerization interface [polypeptide binding]; other site 643867005611 putative DNA binding site [nucleotide binding]; other site 643867005612 putative Zn2+ binding site [ion binding]; other site 643867005613 DNA repair protein RadA; Provisional; Region: PRK11823 643867005614 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 643867005615 Walker A motif/ATP binding site; other site 643867005616 ATP binding site [chemical binding]; other site 643867005617 Walker B motif; other site 643867005618 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 643867005619 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 643867005620 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 643867005621 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 643867005622 Walker A/P-loop; other site 643867005623 ATP binding site [chemical binding]; other site 643867005624 Q-loop/lid; other site 643867005625 ABC transporter signature motif; other site 643867005626 Walker B; other site 643867005627 D-loop; other site 643867005628 H-loop/switch region; other site 643867005629 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 643867005630 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 643867005631 dimerization interface 3.5A [polypeptide binding]; other site 643867005632 active site 643867005633 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 643867005634 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867005635 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 643867005636 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 643867005637 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 643867005638 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 643867005639 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 643867005640 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867005641 catalytic residue [active] 643867005642 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 643867005643 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 643867005644 Lamin Tail Domain; Region: LTD; pfam00932 643867005645 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 643867005646 phosphoglyceromutase; Provisional; Region: PRK05434 643867005647 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 643867005648 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 643867005649 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 643867005650 cofactor binding site; other site 643867005651 DNA binding site [nucleotide binding] 643867005652 substrate interaction site [chemical binding]; other site 643867005653 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 643867005654 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 643867005655 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867005656 ATP binding site [chemical binding]; other site 643867005657 putative Mg++ binding site [ion binding]; other site 643867005658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867005659 nucleotide binding region [chemical binding]; other site 643867005660 ATP-binding site [chemical binding]; other site 643867005661 TRCF domain; Region: TRCF; pfam03461 643867005662 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 643867005663 dimer interface [polypeptide binding]; other site 643867005664 putative tRNA-binding site [nucleotide binding]; other site 643867005665 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 643867005666 MutS domain III; Region: MutS_III; pfam05192 643867005667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867005668 Walker A/P-loop; other site 643867005669 ATP binding site [chemical binding]; other site 643867005670 Q-loop/lid; other site 643867005671 ABC transporter signature motif; other site 643867005672 Walker B; other site 643867005673 D-loop; other site 643867005674 H-loop/switch region; other site 643867005675 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 643867005676 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 643867005677 classical (c) SDRs; Region: SDR_c; cd05233 643867005678 NAD(P) binding site [chemical binding]; other site 643867005679 active site 643867005680 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 643867005681 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 643867005682 ATP10 protein; Region: ATP-synt_10; pfam05176 643867005683 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 643867005684 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 643867005685 Uncharacterized conserved protein [Function unknown]; Region: COG4850 643867005686 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 643867005687 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 643867005688 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 643867005689 dimer interface [polypeptide binding]; other site 643867005690 decamer (pentamer of dimers) interface [polypeptide binding]; other site 643867005691 catalytic triad [active] 643867005692 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 643867005693 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 643867005694 Cl- selectivity filter; other site 643867005695 Cl- binding residues [ion binding]; other site 643867005696 pore gating glutamate residue; other site 643867005697 dimer interface [polypeptide binding]; other site 643867005698 FOG: CBS domain [General function prediction only]; Region: COG0517 643867005699 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 643867005700 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 643867005701 active site triad [active] 643867005702 diaminopimelate decarboxylase; Region: lysA; TIGR01048 643867005703 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 643867005704 active site 643867005705 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 643867005706 substrate binding site [chemical binding]; other site 643867005707 catalytic residues [active] 643867005708 dimer interface [polypeptide binding]; other site 643867005709 putative cation:proton antiport protein; Provisional; Region: PRK10669 643867005710 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 643867005711 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 643867005712 TrkA-N domain; Region: TrkA_N; pfam02254 643867005713 TrkA-C domain; Region: TrkA_C; pfam02080 643867005714 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867005715 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867005716 Histidine kinase; Region: His_kinase; pfam06580 643867005717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867005718 Response regulator receiver domain; Region: Response_reg; pfam00072 643867005719 active site 643867005720 phosphorylation site [posttranslational modification] 643867005721 intermolecular recognition site; other site 643867005722 dimerization interface [polypeptide binding]; other site 643867005723 LytTr DNA-binding domain; Region: LytTR; smart00850 643867005724 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 643867005725 classical (c) SDRs; Region: SDR_c; cd05233 643867005726 NAD(P) binding site [chemical binding]; other site 643867005727 active site 643867005728 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 643867005729 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 643867005730 active site 643867005731 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867005732 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867005733 PKD domain; Region: PKD; pfam00801 643867005734 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867005735 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 643867005736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867005737 non-specific DNA binding site [nucleotide binding]; other site 643867005738 salt bridge; other site 643867005739 sequence-specific DNA binding site [nucleotide binding]; other site 643867005740 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 643867005741 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 643867005742 dimerization interface [polypeptide binding]; other site 643867005743 DPS ferroxidase diiron center [ion binding]; other site 643867005744 ion pore; other site 643867005745 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 643867005746 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 643867005747 putative active site [active] 643867005748 putative metal binding site [ion binding]; other site 643867005749 Protein kinase domain; Region: Pkinase; pfam00069 643867005750 Catalytic domain of Protein Kinases; Region: PKc; cd00180 643867005751 active site 643867005752 ATP binding site [chemical binding]; other site 643867005753 substrate binding site [chemical binding]; other site 643867005754 activation loop (A-loop); other site 643867005755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867005756 binding surface 643867005757 TPR motif; other site 643867005758 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867005759 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867005760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867005761 binding surface 643867005762 TPR motif; other site 643867005763 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867005764 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867005765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867005766 binding surface 643867005767 TPR motif; other site 643867005768 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 643867005769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867005770 DNA binding residues [nucleotide binding] 643867005771 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 643867005772 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867005773 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867005774 DNA binding residues [nucleotide binding] 643867005775 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 643867005776 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 643867005777 minor groove reading motif; other site 643867005778 helix-hairpin-helix signature motif; other site 643867005779 substrate binding pocket [chemical binding]; other site 643867005780 active site 643867005781 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 643867005782 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 643867005783 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 643867005784 transmembrane helices; other site 643867005785 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 643867005786 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 643867005787 putative acyl-acceptor binding pocket; other site 643867005788 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 643867005789 hypothetical protein; Provisional; Region: PRK04164 643867005790 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 643867005791 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 643867005792 gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530 643867005793 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 643867005794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 643867005795 Radical SAM superfamily; Region: Radical_SAM; pfam04055 643867005796 FeS/SAM binding site; other site 643867005797 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 643867005798 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 643867005799 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 643867005800 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867005801 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867005802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867005803 Walker A/P-loop; other site 643867005804 ATP binding site [chemical binding]; other site 643867005805 FOG: WD40 repeat [General function prediction only]; Region: COG2319 643867005806 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 643867005807 TLC ATP/ADP transporter; Region: TLC; cl03940 643867005808 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 643867005809 ligand binding site [chemical binding]; other site 643867005810 flexible hinge region; other site 643867005811 Beta-lactamase; Region: Beta-lactamase; pfam00144 643867005812 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 643867005813 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 643867005814 Archaeal ATPase; Region: Arch_ATPase; pfam01637 643867005815 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 643867005816 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 643867005817 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 643867005818 Repair protein; Region: Repair_PSII; pfam04536 643867005819 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 643867005820 Interdomain contacts; other site 643867005821 Cytokine receptor motif; other site 643867005822 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 643867005823 active site 643867005824 Bacterial SH3 domain; Region: SH3_3; cl17532 643867005825 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 643867005826 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893 643867005827 transcriptional activator RfaH; Region: RfaH; TIGR01955 643867005828 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 643867005829 heterodimer interface [polypeptide binding]; other site 643867005830 homodimer interface [polypeptide binding]; other site 643867005831 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 643867005832 active site 643867005833 NTP binding site [chemical binding]; other site 643867005834 metal binding triad [ion binding]; metal-binding site 643867005835 antibiotic binding site [chemical binding]; other site 643867005836 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 643867005837 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 643867005838 Walker A/P-loop; other site 643867005839 ATP binding site [chemical binding]; other site 643867005840 Q-loop/lid; other site 643867005841 ABC transporter signature motif; other site 643867005842 Walker B; other site 643867005843 D-loop; other site 643867005844 H-loop/switch region; other site 643867005845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 643867005846 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 643867005847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 643867005848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867005849 S-adenosylmethionine binding site [chemical binding]; other site 643867005850 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 643867005851 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867005852 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 643867005853 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 643867005854 active site 643867005855 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 643867005856 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 643867005857 active site 643867005858 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 643867005859 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 643867005860 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 643867005861 active site 643867005862 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867005863 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 643867005864 Protein of unknown function (DUF563); Region: DUF563; pfam04577 643867005865 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 643867005866 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867005867 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 643867005868 active site 643867005869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867005870 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 643867005871 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867005872 PKD domain; Region: PKD; pfam00801 643867005873 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867005874 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867005875 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867005876 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867005877 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867005878 PKD domain; Region: PKD; pfam00801 643867005879 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867005880 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867005881 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867005882 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 643867005883 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 643867005884 NAD(P) binding site [chemical binding]; other site 643867005885 catalytic residues [active] 643867005886 3D domain; Region: 3D; cl01439 643867005887 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 643867005888 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 643867005889 homotrimer interaction site [polypeptide binding]; other site 643867005890 putative active site [active] 643867005891 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 643867005892 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 643867005893 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 643867005894 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 643867005895 NAD(P) binding site [chemical binding]; other site 643867005896 Amidohydrolase; Region: Amidohydro_5; pfam13594 643867005897 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867005898 active site 643867005899 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867005900 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 643867005901 Methyltransferase domain; Region: Methyltransf_31; pfam13847 643867005902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867005903 S-adenosylmethionine binding site [chemical binding]; other site 643867005904 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 643867005905 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 643867005906 malonyl-CoA binding site [chemical binding]; other site 643867005907 dimer interface [polypeptide binding]; other site 643867005908 active site 643867005909 product binding site; other site 643867005910 UbiA prenyltransferase family; Region: UbiA; pfam01040 643867005911 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 643867005912 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 643867005913 NADH(P)-binding; Region: NAD_binding_10; pfam13460 643867005914 NAD(P) binding site [chemical binding]; other site 643867005915 putative active site [active] 643867005916 Recombination protein O N terminal; Region: RecO_N; pfam11967 643867005917 DNA repair protein RecO; Region: reco; TIGR00613 643867005918 Recombination protein O C terminal; Region: RecO_C; pfam02565 643867005919 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 643867005920 thymidine kinase; Provisional; Region: PRK04296 643867005921 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 643867005922 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 643867005923 catalytic loop [active] 643867005924 iron binding site [ion binding]; other site 643867005925 Imelysin; Region: Peptidase_M75; cl09159 643867005926 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 643867005927 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 643867005928 Imelysin; Region: Peptidase_M75; pfam09375 643867005929 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 643867005930 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 643867005931 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 643867005932 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 643867005933 rod shape-determining protein MreC; Provisional; Region: PRK13922 643867005934 rod shape-determining protein MreC; Region: MreC; pfam04085 643867005935 rod shape-determining protein MreB; Provisional; Region: PRK13927 643867005936 MreB and similar proteins; Region: MreB_like; cd10225 643867005937 nucleotide binding site [chemical binding]; other site 643867005938 Mg binding site [ion binding]; other site 643867005939 putative protofilament interaction site [polypeptide binding]; other site 643867005940 RodZ interaction site [polypeptide binding]; other site 643867005941 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 643867005942 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 643867005943 purine monophosphate binding site [chemical binding]; other site 643867005944 dimer interface [polypeptide binding]; other site 643867005945 putative catalytic residues [active] 643867005946 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 643867005947 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 643867005948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867005949 TIGR01777 family protein; Region: yfcH 643867005950 NAD(P) binding site [chemical binding]; other site 643867005951 active site 643867005952 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 643867005953 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 643867005954 putative ligand binding site [chemical binding]; other site 643867005955 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 643867005956 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 643867005957 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 643867005958 active site 643867005959 catalytic triad [active] 643867005960 calcium binding site 1 [ion binding]; other site 643867005961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867005962 PAS domain; Region: PAS_9; pfam13426 643867005963 putative active site [active] 643867005964 heme pocket [chemical binding]; other site 643867005965 PAS domain; Region: PAS_9; pfam13426 643867005966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867005967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867005968 dimer interface [polypeptide binding]; other site 643867005969 phosphorylation site [posttranslational modification] 643867005970 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 643867005971 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 643867005972 HSP70 interaction site [polypeptide binding]; other site 643867005973 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 643867005974 putative active site [active] 643867005975 Zn binding site [ion binding]; other site 643867005976 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 643867005977 DEAD-like helicases superfamily; Region: DEXDc; smart00487 643867005978 ATP binding site [chemical binding]; other site 643867005979 Mg++ binding site [ion binding]; other site 643867005980 motif III; other site 643867005981 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867005982 nucleotide binding region [chemical binding]; other site 643867005983 ATP-binding site [chemical binding]; other site 643867005984 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 643867005985 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 643867005986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867005987 active site 643867005988 phosphorylation site [posttranslational modification] 643867005989 intermolecular recognition site; other site 643867005990 dimerization interface [polypeptide binding]; other site 643867005991 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 643867005992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867005993 active site 643867005994 phosphorylation site [posttranslational modification] 643867005995 intermolecular recognition site; other site 643867005996 dimerization interface [polypeptide binding]; other site 643867005997 PAS domain S-box; Region: sensory_box; TIGR00229 643867005998 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867005999 putative active site [active] 643867006000 heme pocket [chemical binding]; other site 643867006001 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 643867006002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867006003 active site 643867006004 phosphorylation site [posttranslational modification] 643867006005 intermolecular recognition site; other site 643867006006 dimerization interface [polypeptide binding]; other site 643867006007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006008 PAS fold; Region: PAS_3; pfam08447 643867006009 putative active site [active] 643867006010 heme pocket [chemical binding]; other site 643867006011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006012 PAS domain; Region: PAS_9; pfam13426 643867006013 putative active site [active] 643867006014 heme pocket [chemical binding]; other site 643867006015 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 643867006016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006017 putative active site [active] 643867006018 heme pocket [chemical binding]; other site 643867006019 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 643867006020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006021 putative active site [active] 643867006022 heme pocket [chemical binding]; other site 643867006023 GAF domain; Region: GAF_2; pfam13185 643867006024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006025 PAS fold; Region: PAS_3; pfam08447 643867006026 putative active site [active] 643867006027 heme pocket [chemical binding]; other site 643867006028 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 643867006029 GAF domain; Region: GAF; cl17456 643867006030 PAS domain S-box; Region: sensory_box; TIGR00229 643867006031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006032 putative active site [active] 643867006033 heme pocket [chemical binding]; other site 643867006034 PAS fold; Region: PAS_3; pfam08447 643867006035 PAS domain S-box; Region: sensory_box; TIGR00229 643867006036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867006037 dimer interface [polypeptide binding]; other site 643867006038 phosphorylation site [posttranslational modification] 643867006039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867006040 ATP binding site [chemical binding]; other site 643867006041 Mg2+ binding site [ion binding]; other site 643867006042 G-X-G motif; other site 643867006043 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 643867006044 NlpC/P60 family; Region: NLPC_P60; pfam00877 643867006045 FAD binding domain; Region: FAD_binding_4; pfam01565 643867006046 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 643867006047 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867006048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 643867006049 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 643867006050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006051 Walker A/P-loop; other site 643867006052 ATP binding site [chemical binding]; other site 643867006053 Q-loop/lid; other site 643867006054 ABC transporter signature motif; other site 643867006055 Walker B; other site 643867006056 D-loop; other site 643867006057 H-loop/switch region; other site 643867006058 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 643867006059 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 643867006060 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867006061 Outer membrane efflux protein; Region: OEP; pfam02321 643867006062 Outer membrane efflux protein; Region: OEP; pfam02321 643867006063 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 643867006064 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 643867006065 active site 643867006066 dimer interface [polypeptide binding]; other site 643867006067 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 643867006068 Ligand Binding Site [chemical binding]; other site 643867006069 Molecular Tunnel; other site 643867006070 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 643867006071 Predicted acyl esterases [General function prediction only]; Region: COG2936 643867006072 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 643867006073 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 643867006074 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 643867006075 Walker A/P-loop; other site 643867006076 ATP binding site [chemical binding]; other site 643867006077 Q-loop/lid; other site 643867006078 ABC transporter signature motif; other site 643867006079 Walker B; other site 643867006080 D-loop; other site 643867006081 H-loop/switch region; other site 643867006082 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 643867006083 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867006084 FtsX-like permease family; Region: FtsX; pfam02687 643867006085 FtsX-like permease family; Region: FtsX; pfam02687 643867006086 Methyltransferase domain; Region: Methyltransf_23; pfam13489 643867006087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867006088 S-adenosylmethionine binding site [chemical binding]; other site 643867006089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 643867006090 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 643867006091 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 643867006092 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 643867006093 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 643867006094 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 643867006095 putative metal binding site [ion binding]; other site 643867006096 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 643867006097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867006098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 643867006099 putative substrate translocation pore; other site 643867006100 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 643867006101 short chain dehydrogenase; Provisional; Region: PRK06197 643867006102 putative NAD(P) binding site [chemical binding]; other site 643867006103 active site 643867006104 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 643867006105 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 643867006106 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 643867006107 Potassium binding sites [ion binding]; other site 643867006108 Cesium cation binding sites [ion binding]; other site 643867006109 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 643867006110 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 643867006111 MutS domain I; Region: MutS_I; pfam01624 643867006112 MutS domain II; Region: MutS_II; pfam05188 643867006113 MutS domain III; Region: MutS_III; pfam05192 643867006114 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 643867006115 Walker A/P-loop; other site 643867006116 ATP binding site [chemical binding]; other site 643867006117 Q-loop/lid; other site 643867006118 ABC transporter signature motif; other site 643867006119 Walker B; other site 643867006120 D-loop; other site 643867006121 H-loop/switch region; other site 643867006122 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 643867006123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006124 putative active site [active] 643867006125 heme pocket [chemical binding]; other site 643867006126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867006127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867006128 phosphorylation site [posttranslational modification] 643867006129 dimer interface [polypeptide binding]; other site 643867006130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867006131 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 643867006132 Fatty acid desaturase; Region: FA_desaturase; pfam00487 643867006133 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 643867006134 Di-iron ligands [ion binding]; other site 643867006135 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 643867006136 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 643867006137 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 643867006138 NAD(P) binding site [chemical binding]; other site 643867006139 Surface antigen; Region: Bac_surface_Ag; pfam01103 643867006140 Family of unknown function (DUF490); Region: DUF490; pfam04357 643867006141 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 643867006142 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 643867006143 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 643867006144 active site 643867006145 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 643867006146 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867006147 catalytic residues [active] 643867006148 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 643867006149 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867006150 catalytic residue [active] 643867006151 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867006152 von Willebrand factor; Region: vWF_A; pfam12450 643867006153 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 643867006154 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 643867006155 metal ion-dependent adhesion site (MIDAS); other site 643867006156 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 643867006157 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 643867006158 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867006159 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 643867006160 DNA binding residues [nucleotide binding] 643867006161 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867006162 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 643867006163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006164 Walker A/P-loop; other site 643867006165 ATP binding site [chemical binding]; other site 643867006166 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 643867006167 active site 643867006168 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 643867006169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867006170 active site 643867006171 phosphorylation site [posttranslational modification] 643867006172 intermolecular recognition site; other site 643867006173 dimerization interface [polypeptide binding]; other site 643867006174 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 643867006175 GAF domain; Region: GAF; pfam01590 643867006176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006177 putative active site [active] 643867006178 heme pocket [chemical binding]; other site 643867006179 PAS fold; Region: PAS; pfam00989 643867006180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006181 putative active site [active] 643867006182 heme pocket [chemical binding]; other site 643867006183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006184 putative active site [active] 643867006185 PAS fold; Region: PAS_3; pfam08447 643867006186 heme pocket [chemical binding]; other site 643867006187 PAS domain S-box; Region: sensory_box; TIGR00229 643867006188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006189 putative active site [active] 643867006190 heme pocket [chemical binding]; other site 643867006191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006192 PAS domain; Region: PAS_9; pfam13426 643867006193 putative active site [active] 643867006194 heme pocket [chemical binding]; other site 643867006195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867006196 dimer interface [polypeptide binding]; other site 643867006197 phosphorylation site [posttranslational modification] 643867006198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867006199 ATP binding site [chemical binding]; other site 643867006200 Mg2+ binding site [ion binding]; other site 643867006201 G-X-G motif; other site 643867006202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006203 Walker A/P-loop; other site 643867006204 ATP binding site [chemical binding]; other site 643867006205 Q-loop/lid; other site 643867006206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006207 ABC transporter signature motif; other site 643867006208 Walker B; other site 643867006209 D-loop; other site 643867006210 H-loop/switch region; other site 643867006211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006212 Q-loop/lid; other site 643867006213 ABC transporter signature motif; other site 643867006214 Walker B; other site 643867006215 D-loop; other site 643867006216 H-loop/switch region; other site 643867006217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006218 Walker A/P-loop; other site 643867006219 ATP binding site [chemical binding]; other site 643867006220 Q-loop/lid; other site 643867006221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006222 ABC transporter signature motif; other site 643867006223 Walker B; other site 643867006224 D-loop; other site 643867006225 H-loop/switch region; other site 643867006226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006227 AAA domain; Region: AAA_21; pfam13304 643867006228 Walker A/P-loop; other site 643867006229 ATP binding site [chemical binding]; other site 643867006230 Q-loop/lid; other site 643867006231 ABC transporter signature motif; other site 643867006232 Walker B; other site 643867006233 D-loop; other site 643867006234 H-loop/switch region; other site 643867006235 Transposase IS200 like; Region: Y1_Tnp; pfam01797 643867006236 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 643867006237 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 643867006238 G1 box; other site 643867006239 putative GEF interaction site [polypeptide binding]; other site 643867006240 GTP/Mg2+ binding site [chemical binding]; other site 643867006241 Switch I region; other site 643867006242 G2 box; other site 643867006243 G3 box; other site 643867006244 Switch II region; other site 643867006245 G4 box; other site 643867006246 G5 box; other site 643867006247 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 643867006248 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 643867006249 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 643867006250 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 643867006251 Methyltransferase domain; Region: Methyltransf_23; pfam13489 643867006252 Methyltransferase domain; Region: Methyltransf_11; pfam08241 643867006253 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 643867006254 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 643867006255 dimerization interface [polypeptide binding]; other site 643867006256 putative ATP binding site [chemical binding]; other site 643867006257 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 643867006258 thiamine phosphate binding site [chemical binding]; other site 643867006259 active site 643867006260 pyrophosphate binding site [ion binding]; other site 643867006261 Trm112p-like protein; Region: Trm112p; cl01066 643867006262 AAA domain; Region: AAA_21; pfam13304 643867006263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 643867006264 putative Mg++ binding site [ion binding]; other site 643867006265 AAA domain; Region: AAA_13; pfam13166 643867006266 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867006267 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 643867006268 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867006269 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 643867006270 ligand binding site [chemical binding]; other site 643867006271 flexible hinge region; other site 643867006272 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 643867006273 non-specific DNA interactions [nucleotide binding]; other site 643867006274 DNA binding site [nucleotide binding] 643867006275 sequence specific DNA binding site [nucleotide binding]; other site 643867006276 putative cAMP binding site [chemical binding]; other site 643867006277 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 643867006278 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 643867006279 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 643867006280 active site 643867006281 FMN binding site [chemical binding]; other site 643867006282 substrate binding site [chemical binding]; other site 643867006283 3Fe-4S cluster binding site [ion binding]; other site 643867006284 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867006285 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 643867006286 ligand binding site [chemical binding]; other site 643867006287 enoyl-CoA hydratase; Provisional; Region: PRK06142 643867006288 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 643867006289 substrate binding site [chemical binding]; other site 643867006290 oxyanion hole (OAH) forming residues; other site 643867006291 trimer interface [polypeptide binding]; other site 643867006292 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 643867006293 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 643867006294 active site 643867006295 metal binding site [ion binding]; metal-binding site 643867006296 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 643867006297 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 643867006298 potential catalytic triad [active] 643867006299 conserved cys residue [active] 643867006300 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 643867006301 Prostaglandin dehydrogenases; Region: PGDH; cd05288 643867006302 NAD(P) binding site [chemical binding]; other site 643867006303 substrate binding site [chemical binding]; other site 643867006304 dimer interface [polypeptide binding]; other site 643867006305 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 643867006306 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 643867006307 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 643867006308 putative NAD(P) binding site [chemical binding]; other site 643867006309 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 643867006310 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 643867006311 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 643867006312 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 643867006313 active site 643867006314 Zn binding site [ion binding]; other site 643867006315 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 643867006316 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 643867006317 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 643867006318 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 643867006319 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 643867006320 Histidine kinase; Region: His_kinase; pfam06580 643867006321 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 643867006322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867006323 active site 643867006324 phosphorylation site [posttranslational modification] 643867006325 intermolecular recognition site; other site 643867006326 dimerization interface [polypeptide binding]; other site 643867006327 LytTr DNA-binding domain; Region: LytTR; smart00850 643867006328 nicotinate-nucleotide diphosphorylase (carboxylating); Region: PLN02716 643867006329 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 643867006330 dimerization interface [polypeptide binding]; other site 643867006331 active site 643867006332 YcxB-like protein; Region: YcxB; pfam14317 643867006333 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 643867006334 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 643867006335 active site 643867006336 substrate binding site [chemical binding]; other site 643867006337 cosubstrate binding site; other site 643867006338 catalytic site [active] 643867006339 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 643867006340 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 643867006341 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867006342 catalytic residues [active] 643867006343 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 643867006344 Methyltransferase domain; Region: Methyltransf_11; pfam08241 643867006345 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 643867006346 DoxX-like family; Region: DoxX_3; pfam13781 643867006347 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 643867006348 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 643867006349 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 643867006350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 643867006351 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 643867006352 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 643867006353 active site 643867006354 Zn binding site [ion binding]; other site 643867006355 SnoaL-like domain; Region: SnoaL_2; pfam12680 643867006356 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 643867006357 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 643867006358 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 643867006359 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 643867006360 active site 643867006361 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 643867006362 Carbon starvation protein CstA; Region: CstA; pfam02554 643867006363 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 643867006364 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 643867006365 Bacterial Ig-like domain; Region: Big_5; pfam13205 643867006366 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 643867006367 Methyltransferase domain; Region: Methyltransf_23; pfam13489 643867006368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867006369 S-adenosylmethionine binding site [chemical binding]; other site 643867006370 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 643867006371 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 643867006372 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 643867006373 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 643867006374 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 643867006375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 643867006376 ATP binding site [chemical binding]; other site 643867006377 Mg2+ binding site [ion binding]; other site 643867006378 G-X-G motif; other site 643867006379 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 643867006380 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 643867006381 putative active site [active] 643867006382 putative catalytic site [active] 643867006383 putative DNA binding site [nucleotide binding]; other site 643867006384 putative phosphate binding site [ion binding]; other site 643867006385 metal binding site A [ion binding]; metal-binding site 643867006386 putative AP binding site [nucleotide binding]; other site 643867006387 putative metal binding site B [ion binding]; other site 643867006388 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 643867006389 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 643867006390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 643867006391 active site 643867006392 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 643867006393 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 643867006394 substrate binding pocket [chemical binding]; other site 643867006395 membrane-bound complex binding site; other site 643867006396 hinge residues; other site 643867006397 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 643867006398 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 643867006399 P-loop; other site 643867006400 Magnesium ion binding site [ion binding]; other site 643867006401 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 643867006402 putative FMN binding site [chemical binding]; other site 643867006403 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 643867006404 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 643867006405 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 643867006406 dimer interface [polypeptide binding]; other site 643867006407 motif 1; other site 643867006408 active site 643867006409 motif 2; other site 643867006410 motif 3; other site 643867006411 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 643867006412 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 643867006413 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 643867006414 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 643867006415 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 643867006416 Zn2+ binding site [ion binding]; other site 643867006417 Mg2+ binding site [ion binding]; other site 643867006418 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 643867006419 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 643867006420 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 643867006421 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 643867006422 serine racemase; Region: PLN02970 643867006423 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 643867006424 tetramer interface [polypeptide binding]; other site 643867006425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867006426 catalytic residue [active] 643867006427 Response regulator receiver domain; Region: Response_reg; pfam00072 643867006428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867006429 active site 643867006430 phosphorylation site [posttranslational modification] 643867006431 intermolecular recognition site; other site 643867006432 dimerization interface [polypeptide binding]; other site 643867006433 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 643867006434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867006435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867006436 DNA binding residues [nucleotide binding] 643867006437 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 643867006438 HAMP domain; Region: HAMP; pfam00672 643867006439 dimerization interface [polypeptide binding]; other site 643867006440 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 643867006441 GAF domain; Region: GAF; pfam01590 643867006442 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 643867006443 peptide chain release factor 1; Validated; Region: prfA; PRK00591 643867006444 This domain is found in peptide chain release factors; Region: PCRF; smart00937 643867006445 RF-1 domain; Region: RF-1; pfam00472 643867006446 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 643867006447 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 643867006448 active site 643867006449 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867006450 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 643867006451 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 643867006452 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 643867006453 active site 643867006454 DNA binding site [nucleotide binding] 643867006455 Int/Topo IB signature motif; other site 643867006456 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 643867006457 30S subunit binding site; other site 643867006458 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867006459 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867006460 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867006461 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 643867006462 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 643867006463 Imelysin; Region: Peptidase_M75; pfam09375 643867006464 fumarate hydratase; Reviewed; Region: fumC; PRK00485 643867006465 Class II fumarases; Region: Fumarase_classII; cd01362 643867006466 active site 643867006467 tetramer interface [polypeptide binding]; other site 643867006468 Sporulation related domain; Region: SPOR; cl10051 643867006469 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 643867006470 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 643867006471 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 643867006472 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 643867006473 active site 643867006474 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 643867006475 dimer interface [polypeptide binding]; other site 643867006476 substrate binding site [chemical binding]; other site 643867006477 catalytic residues [active] 643867006478 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 643867006479 putative catalytic site [active] 643867006480 putative metal binding site [ion binding]; other site 643867006481 putative phosphate binding site [ion binding]; other site 643867006482 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 643867006483 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 643867006484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006485 Walker A/P-loop; other site 643867006486 ATP binding site [chemical binding]; other site 643867006487 Q-loop/lid; other site 643867006488 ABC transporter signature motif; other site 643867006489 Walker B; other site 643867006490 D-loop; other site 643867006491 H-loop/switch region; other site 643867006492 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 643867006493 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 643867006494 GAF domain; Region: GAF_3; pfam13492 643867006495 YceI-like domain; Region: YceI; pfam04264 643867006496 YceI-like domain; Region: YceI; cl01001 643867006497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867006498 salt bridge; other site 643867006499 non-specific DNA binding site [nucleotide binding]; other site 643867006500 sequence-specific DNA binding site [nucleotide binding]; other site 643867006501 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 643867006502 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 643867006503 active site 643867006504 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 643867006505 AAA domain; Region: AAA_33; pfam13671 643867006506 ligand-binding site [chemical binding]; other site 643867006507 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 643867006508 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 643867006509 Active Sites [active] 643867006510 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 643867006511 four helix bundle protein; Region: TIGR02436 643867006512 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 643867006513 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 643867006514 CysD dimerization site [polypeptide binding]; other site 643867006515 G1 box; other site 643867006516 putative GEF interaction site [polypeptide binding]; other site 643867006517 GTP/Mg2+ binding site [chemical binding]; other site 643867006518 Switch I region; other site 643867006519 G2 box; other site 643867006520 G3 box; other site 643867006521 Switch II region; other site 643867006522 G4 box; other site 643867006523 G5 box; other site 643867006524 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 643867006525 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 643867006526 RecX family; Region: RecX; pfam02631 643867006527 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 643867006528 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 643867006529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867006530 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867006531 catalytic residue [active] 643867006532 catalytic residue [active] 643867006533 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 643867006534 Protein of unknown function, DUF608; Region: DUF608; pfam04685 643867006535 Response regulator receiver domain; Region: Response_reg; pfam00072 643867006536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867006537 active site 643867006538 phosphorylation site [posttranslational modification] 643867006539 intermolecular recognition site; other site 643867006540 dimerization interface [polypeptide binding]; other site 643867006541 aldehyde dehydrogenase family 7 member; Region: PLN02315 643867006542 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 643867006543 tetrameric interface [polypeptide binding]; other site 643867006544 NAD binding site [chemical binding]; other site 643867006545 catalytic residues [active] 643867006546 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 643867006547 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 643867006548 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 643867006549 protein binding site [polypeptide binding]; other site 643867006550 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 643867006551 protein binding site [polypeptide binding]; other site 643867006552 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 643867006553 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 643867006554 putative dimer interface [polypeptide binding]; other site 643867006555 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 643867006556 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 643867006557 active site 643867006558 HIGH motif; other site 643867006559 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 643867006560 KMSKS motif; other site 643867006561 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 643867006562 tRNA binding surface [nucleotide binding]; other site 643867006563 anticodon binding site; other site 643867006564 ribosome maturation protein RimP; Reviewed; Region: PRK00092 643867006565 Sm and related proteins; Region: Sm_like; cl00259 643867006566 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 643867006567 putative oligomer interface [polypeptide binding]; other site 643867006568 putative RNA binding site [nucleotide binding]; other site 643867006569 transcription termination factor NusA; Region: NusA; TIGR01953 643867006570 NusA N-terminal domain; Region: NusA_N; pfam08529 643867006571 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 643867006572 RNA binding site [nucleotide binding]; other site 643867006573 homodimer interface [polypeptide binding]; other site 643867006574 NusA-like KH domain; Region: KH_5; pfam13184 643867006575 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 643867006576 G-X-X-G motif; other site 643867006577 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 643867006578 translation initiation factor IF-2; Region: IF-2; TIGR00487 643867006579 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 643867006580 G1 box; other site 643867006581 putative GEF interaction site [polypeptide binding]; other site 643867006582 GTP/Mg2+ binding site [chemical binding]; other site 643867006583 Switch I region; other site 643867006584 G2 box; other site 643867006585 G3 box; other site 643867006586 Switch II region; other site 643867006587 G4 box; other site 643867006588 G5 box; other site 643867006589 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 643867006590 Translation-initiation factor 2; Region: IF-2; pfam11987 643867006591 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 643867006592 PGAP1-like protein; Region: PGAP1; pfam07819 643867006593 Bacterial SH3 domain; Region: SH3_3; cl17532 643867006594 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 643867006595 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867006596 BNR repeat-like domain; Region: BNR_2; pfam13088 643867006597 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867006598 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 643867006599 ligand binding site [chemical binding]; other site 643867006600 flexible hinge region; other site 643867006601 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 643867006602 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 643867006603 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 643867006604 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867006605 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 643867006606 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867006607 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 643867006608 Zn binding site [ion binding]; other site 643867006609 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 643867006610 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 643867006611 Protein export membrane protein; Region: SecD_SecF; cl14618 643867006612 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 643867006613 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 643867006614 active site 643867006615 HIGH motif; other site 643867006616 nucleotide binding site [chemical binding]; other site 643867006617 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 643867006618 active site 643867006619 KMSKS motif; other site 643867006620 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 643867006621 tRNA binding surface [nucleotide binding]; other site 643867006622 anticodon binding site; other site 643867006623 lipoprotein signal peptidase; Provisional; Region: PRK14787 643867006624 lipoprotein signal peptidase; Provisional; Region: PRK14788 643867006625 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 643867006626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867006627 binding surface 643867006628 TPR motif; other site 643867006629 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 643867006630 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 643867006631 catalytic motif [active] 643867006632 Catalytic residue [active] 643867006633 protein binding site [polypeptide binding]; other site 643867006634 Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228 643867006635 CAAX protease self-immunity; Region: Abi; pfam02517 643867006636 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 643867006637 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 643867006638 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 643867006639 M28 Zn-Peptidases; Region: M28_like_2; cd05662 643867006640 Peptidase family M28; Region: Peptidase_M28; pfam04389 643867006641 metal binding site [ion binding]; metal-binding site 643867006642 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 643867006643 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 643867006644 putative active site [active] 643867006645 putative catalytic site [active] 643867006646 M28 Zn-Peptidases; Region: M28_like_6; cd08656 643867006647 Peptidase family M28; Region: Peptidase_M28; pfam04389 643867006648 metal binding site [ion binding]; metal-binding site 643867006649 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 643867006650 UbiA prenyltransferase family; Region: UbiA; pfam01040 643867006651 Rossmann-like domain; Region: Rossmann-like; pfam10727 643867006652 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 643867006653 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 643867006654 CcmE; Region: CcmE; cl00994 643867006655 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 643867006656 CcmB protein; Region: CcmB; cl17444 643867006657 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 643867006658 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 643867006659 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 643867006660 NAD binding site [chemical binding]; other site 643867006661 substrate binding site [chemical binding]; other site 643867006662 homodimer interface [polypeptide binding]; other site 643867006663 active site 643867006664 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 643867006665 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 643867006666 substrate binding site; other site 643867006667 tetramer interface; other site 643867006668 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 643867006669 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 643867006670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006671 Walker A/P-loop; other site 643867006672 ATP binding site [chemical binding]; other site 643867006673 Q-loop/lid; other site 643867006674 ABC transporter signature motif; other site 643867006675 Walker B; other site 643867006676 D-loop; other site 643867006677 H-loop/switch region; other site 643867006678 Integral membrane protein TerC family; Region: TerC; cl10468 643867006679 tellurium resistance terB-like protein; Region: terB_like; cd07177 643867006680 metal binding site [ion binding]; metal-binding site 643867006681 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 643867006682 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867006683 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 643867006684 N-acetyl-D-glucosamine binding site [chemical binding]; other site 643867006685 catalytic residue [active] 643867006686 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 643867006687 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 643867006688 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 643867006689 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 643867006690 putative acyl-acceptor binding pocket; other site 643867006691 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 643867006692 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 643867006693 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 643867006694 Walker A/P-loop; other site 643867006695 ATP binding site [chemical binding]; other site 643867006696 Q-loop/lid; other site 643867006697 ABC transporter signature motif; other site 643867006698 Walker B; other site 643867006699 D-loop; other site 643867006700 H-loop/switch region; other site 643867006701 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 643867006702 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 643867006703 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 643867006704 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867006705 Domain of unknown function (DUF427); Region: DUF427; pfam04248 643867006706 Ion channel; Region: Ion_trans_2; pfam07885 643867006707 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 643867006708 TrkA-N domain; Region: TrkA_N; pfam02254 643867006709 TrkA-C domain; Region: TrkA_C; pfam02080 643867006710 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 643867006711 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 643867006712 aspartate kinase III; Validated; Region: PRK09084 643867006713 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 643867006714 nucleotide binding site [chemical binding]; other site 643867006715 substrate binding site [chemical binding]; other site 643867006716 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 643867006717 dimer interface [polypeptide binding]; other site 643867006718 allosteric regulatory binding pocket; other site 643867006719 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 643867006720 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 643867006721 homopentamer interface [polypeptide binding]; other site 643867006722 active site 643867006723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867006724 binding surface 643867006725 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 643867006726 TPR motif; other site 643867006727 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 643867006728 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 643867006729 tetramer interface [polypeptide binding]; other site 643867006730 TPP-binding site [chemical binding]; other site 643867006731 heterodimer interface [polypeptide binding]; other site 643867006732 phosphorylation loop region [posttranslational modification] 643867006733 recombination protein F; Reviewed; Region: recF; PRK00064 643867006734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006735 Walker A/P-loop; other site 643867006736 ATP binding site [chemical binding]; other site 643867006737 Q-loop/lid; other site 643867006738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867006739 ABC transporter signature motif; other site 643867006740 Walker B; other site 643867006741 D-loop; other site 643867006742 Protein of unknown function (DUF721); Region: DUF721; pfam05258 643867006743 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 643867006744 active site 643867006745 catalytic triad [active] 643867006746 oxyanion hole [active] 643867006747 switch loop; other site 643867006748 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 643867006749 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 643867006750 DinB family; Region: DinB; cl17821 643867006751 DinB superfamily; Region: DinB_2; pfam12867 643867006752 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 643867006753 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 643867006754 HIGH motif; other site 643867006755 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 643867006756 active site 643867006757 KMSKS motif; other site 643867006758 Endonuclease I; Region: Endonuclease_1; pfam04231 643867006759 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 643867006760 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 643867006761 Interdomain contacts; other site 643867006762 Cytokine receptor motif; other site 643867006763 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 643867006764 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867006765 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 643867006766 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 643867006767 active site 643867006768 homotetramer interface [polypeptide binding]; other site 643867006769 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 643867006770 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 643867006771 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 643867006772 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 643867006773 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 643867006774 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 643867006775 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 643867006776 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 643867006777 active site 643867006778 dimer interface [polypeptide binding]; other site 643867006779 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 643867006780 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 643867006781 active site 643867006782 FMN binding site [chemical binding]; other site 643867006783 substrate binding site [chemical binding]; other site 643867006784 3Fe-4S cluster binding site [ion binding]; other site 643867006785 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 643867006786 domain interface; other site 643867006787 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 643867006788 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 643867006789 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 643867006790 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 643867006791 acyl-activating enzyme (AAE) consensus motif; other site 643867006792 putative AMP binding site [chemical binding]; other site 643867006793 putative active site [active] 643867006794 putative CoA binding site [chemical binding]; other site 643867006795 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 643867006796 active site 643867006797 multimer interface [polypeptide binding]; other site 643867006798 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 643867006799 DHH family; Region: DHH; pfam01368 643867006800 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 643867006801 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 643867006802 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 643867006803 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 643867006804 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 643867006805 active site 643867006806 dimerization interface [polypeptide binding]; other site 643867006807 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 643867006808 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 643867006809 ATP-binding site [chemical binding]; other site 643867006810 Sugar specificity; other site 643867006811 Pyrimidine base specificity; other site 643867006812 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 643867006813 TrkA-N domain; Region: TrkA_N; pfam02254 643867006814 TrkA-C domain; Region: TrkA_C; pfam02080 643867006815 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867006816 hypothetical protein; Provisional; Region: PRK10279 643867006817 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 643867006818 active site 643867006819 nucleophile elbow; other site 643867006820 Methyltransferase domain; Region: Methyltransf_31; pfam13847 643867006821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867006822 S-adenosylmethionine binding site [chemical binding]; other site 643867006823 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867006824 PAS fold; Region: PAS_3; pfam08447 643867006825 putative active site [active] 643867006826 heme pocket [chemical binding]; other site 643867006827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867006828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867006829 dimer interface [polypeptide binding]; other site 643867006830 phosphorylation site [posttranslational modification] 643867006831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867006832 ATP binding site [chemical binding]; other site 643867006833 Mg2+ binding site [ion binding]; other site 643867006834 G-X-G motif; other site 643867006835 glycyl-tRNA synthetase; Provisional; Region: PRK04173 643867006836 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 643867006837 motif 1; other site 643867006838 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 643867006839 active site 643867006840 motif 2; other site 643867006841 motif 3; other site 643867006842 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 643867006843 anticodon binding site; other site 643867006844 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 643867006845 catalytic residues [active] 643867006846 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 643867006847 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 643867006848 substrate binding pocket [chemical binding]; other site 643867006849 membrane-bound complex binding site; other site 643867006850 hinge residues; other site 643867006851 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 643867006852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 643867006853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 643867006854 Histidine kinase; Region: His_kinase; pfam06580 643867006855 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 643867006856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867006857 active site 643867006858 phosphorylation site [posttranslational modification] 643867006859 intermolecular recognition site; other site 643867006860 dimerization interface [polypeptide binding]; other site 643867006861 LytTr DNA-binding domain; Region: LytTR; smart00850 643867006862 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 643867006863 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 643867006864 FeS/SAM binding site; other site 643867006865 HemN C-terminal domain; Region: HemN_C; pfam06969 643867006866 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 643867006867 active site 643867006868 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 643867006869 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 643867006870 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 643867006871 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 643867006872 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 643867006873 GldM N-terminal domain; Region: GldM_N; pfam12081 643867006874 GldM C-terminal domain; Region: GldM_C; pfam12080 643867006875 gliding motility associated protien GldN; Region: GldN; TIGR03523 643867006876 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 643867006877 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 643867006878 GIY-YIG motif/motif A; other site 643867006879 active site 643867006880 catalytic site [active] 643867006881 putative DNA binding site [nucleotide binding]; other site 643867006882 metal binding site [ion binding]; metal-binding site 643867006883 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 643867006884 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 643867006885 Transglycosylase; Region: Transgly; pfam00912 643867006886 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 643867006887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867006888 binding surface 643867006889 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867006890 TPR motif; other site 643867006891 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 643867006892 Peptidase family M23; Region: Peptidase_M23; pfam01551 643867006893 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 643867006894 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 643867006895 ATP synthase A chain; Region: ATP-synt_A; cl00413 643867006896 ATP synthase subunit C; Region: ATP-synt_C; cl00466 643867006897 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 643867006898 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 643867006899 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 643867006900 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 643867006901 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 643867006902 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 643867006903 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 643867006904 beta subunit interaction interface [polypeptide binding]; other site 643867006905 Walker A motif; other site 643867006906 ATP binding site [chemical binding]; other site 643867006907 Walker B motif; other site 643867006908 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 643867006909 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 643867006910 core domain interface [polypeptide binding]; other site 643867006911 delta subunit interface [polypeptide binding]; other site 643867006912 epsilon subunit interface [polypeptide binding]; other site 643867006913 FOG: CBS domain [General function prediction only]; Region: COG0517 643867006914 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 643867006915 Methyltransferase domain; Region: Methyltransf_23; pfam13489 643867006916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 643867006917 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 643867006918 Part of AAA domain; Region: AAA_19; pfam13245 643867006919 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 643867006920 AAA domain; Region: AAA_12; pfam13087 643867006921 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 643867006922 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 643867006923 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 643867006924 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 643867006925 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 643867006926 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 643867006927 ATP-grasp domain; Region: ATP-grasp; pfam02222 643867006928 AIR carboxylase; Region: AIRC; pfam00731 643867006929 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867006930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867006931 binding surface 643867006932 TPR motif; other site 643867006933 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867006934 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867006935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867006936 binding surface 643867006937 TPR motif; other site 643867006938 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867006939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867006940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867006941 dimer interface [polypeptide binding]; other site 643867006942 phosphorylation site [posttranslational modification] 643867006943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867006944 ATP binding site [chemical binding]; other site 643867006945 Mg2+ binding site [ion binding]; other site 643867006946 G-X-G motif; other site 643867006947 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 643867006948 active site 643867006949 Zn binding site [ion binding]; other site 643867006950 excinuclease ABC subunit B; Provisional; Region: PRK05298 643867006951 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867006952 ATP binding site [chemical binding]; other site 643867006953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867006954 nucleotide binding region [chemical binding]; other site 643867006955 ATP-binding site [chemical binding]; other site 643867006956 Ultra-violet resistance protein B; Region: UvrB; pfam12344 643867006957 Domain of unknown function DUF302; Region: DUF302; pfam03625 643867006958 Domain of unknown function DUF21; Region: DUF21; pfam01595 643867006959 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 643867006960 Domain of unknown function DUF21; Region: DUF21; pfam01595 643867006961 gliding motility-associated protein GldE; Region: GldE; TIGR03520 643867006962 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 643867006963 Transporter associated domain; Region: CorC_HlyC; smart01091 643867006964 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 643867006965 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 643867006966 dimer interface [polypeptide binding]; other site 643867006967 ssDNA binding site [nucleotide binding]; other site 643867006968 tetramer (dimer of dimers) interface [polypeptide binding]; other site 643867006969 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 643867006970 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 643867006971 minor groove reading motif; other site 643867006972 helix-hairpin-helix signature motif; other site 643867006973 substrate binding pocket [chemical binding]; other site 643867006974 active site 643867006975 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 643867006976 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 643867006977 DNA binding and oxoG recognition site [nucleotide binding] 643867006978 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 643867006979 IHF dimer interface [polypeptide binding]; other site 643867006980 IHF - DNA interface [nucleotide binding]; other site 643867006981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867006982 binding surface 643867006983 Tetratricopeptide repeat; Region: TPR_16; pfam13432 643867006984 TPR motif; other site 643867006985 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 643867006986 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 643867006987 homodimer interface [polypeptide binding]; other site 643867006988 oligonucleotide binding site [chemical binding]; other site 643867006989 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 643867006990 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 643867006991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867006992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 643867006993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867006994 ATP binding site [chemical binding]; other site 643867006995 Mg2+ binding site [ion binding]; other site 643867006996 G-X-G motif; other site 643867006997 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867006998 ferrochelatase; Reviewed; Region: hemH; PRK00035 643867006999 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 643867007000 C-terminal domain interface [polypeptide binding]; other site 643867007001 active site 643867007002 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 643867007003 active site 643867007004 N-terminal domain interface [polypeptide binding]; other site 643867007005 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 643867007006 GAF domain; Region: GAF_2; pfam13185 643867007007 GAF domain; Region: GAF_3; pfam13492 643867007008 PAS domain; Region: PAS_9; pfam13426 643867007009 DNA photolyase; Region: DNA_photolyase; pfam00875 643867007010 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 643867007011 triosephosphate isomerase; Provisional; Region: PRK14567 643867007012 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 643867007013 substrate binding site [chemical binding]; other site 643867007014 dimer interface [polypeptide binding]; other site 643867007015 catalytic triad [active] 643867007016 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 643867007017 hypothetical protein; Provisional; Region: PRK08201 643867007018 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 643867007019 metal binding site [ion binding]; metal-binding site 643867007020 putative dimer interface [polypeptide binding]; other site 643867007021 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 643867007022 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 643867007023 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 643867007024 Ribosome-binding factor A; Region: RBFA; pfam02033 643867007025 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 643867007026 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867007027 FtsX-like permease family; Region: FtsX; pfam02687 643867007028 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 643867007029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867007030 ATP binding site [chemical binding]; other site 643867007031 putative Mg++ binding site [ion binding]; other site 643867007032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867007033 nucleotide binding region [chemical binding]; other site 643867007034 ATP-binding site [chemical binding]; other site 643867007035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867007036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 643867007037 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 643867007038 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 643867007039 Walker A/P-loop; other site 643867007040 ATP binding site [chemical binding]; other site 643867007041 Q-loop/lid; other site 643867007042 ABC transporter signature motif; other site 643867007043 Walker B; other site 643867007044 D-loop; other site 643867007045 H-loop/switch region; other site 643867007046 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867007047 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 643867007048 FtsX-like permease family; Region: FtsX; pfam02687 643867007049 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 643867007050 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867007051 MucB/RseB family; Region: MucB_RseB; pfam03888 643867007052 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 643867007053 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 643867007054 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 643867007055 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 643867007056 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 643867007057 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 643867007058 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 643867007059 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 643867007060 Walker A/P-loop; other site 643867007061 ATP binding site [chemical binding]; other site 643867007062 Q-loop/lid; other site 643867007063 ABC transporter signature motif; other site 643867007064 Walker B; other site 643867007065 D-loop; other site 643867007066 H-loop/switch region; other site 643867007067 PUCC protein; Region: PUCC; pfam03209 643867007068 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 643867007069 dimer interface [polypeptide binding]; other site 643867007070 active site 643867007071 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 643867007072 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 643867007073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867007074 Walker A motif; other site 643867007075 ATP binding site [chemical binding]; other site 643867007076 Walker B motif; other site 643867007077 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 643867007078 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 643867007079 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 643867007080 Cwf15/Cwc15 cell cycle control protein; Region: Cwf_Cwc_15; pfam04889 643867007081 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 643867007082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867007083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867007084 ATP binding site [chemical binding]; other site 643867007085 Mg2+ binding site [ion binding]; other site 643867007086 G-X-G motif; other site 643867007087 starch binding outer membrane protein SusD; Region: SusD; cd08977 643867007088 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 643867007089 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867007090 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867007091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 643867007092 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 643867007093 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 643867007094 Sodium Bile acid symporter family; Region: SBF; cl17470 643867007095 Low molecular weight phosphatase family; Region: LMWPc; cl00105 643867007096 active site 643867007097 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 643867007098 dimerization interface [polypeptide binding]; other site 643867007099 putative DNA binding site [nucleotide binding]; other site 643867007100 putative Zn2+ binding site [ion binding]; other site 643867007101 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 643867007102 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 643867007103 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 643867007104 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 643867007105 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659 643867007106 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 643867007107 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 643867007108 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 643867007109 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 643867007110 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 643867007111 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 643867007112 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 643867007113 active site 643867007114 substrate binding site [chemical binding]; other site 643867007115 metal binding site [ion binding]; metal-binding site 643867007116 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 643867007117 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 643867007118 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867007119 catalytic residue [active] 643867007120 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867007121 Ligand Binding Site [chemical binding]; other site 643867007122 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867007123 Ligand Binding Site [chemical binding]; other site 643867007124 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 643867007125 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 643867007126 active site 643867007127 Zn binding site [ion binding]; other site 643867007128 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 643867007129 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 643867007130 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 643867007131 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867007132 catalytic residue [active] 643867007133 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 643867007134 gamma subunit interface [polypeptide binding]; other site 643867007135 LBP interface [polypeptide binding]; other site 643867007136 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 643867007137 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 643867007138 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 643867007139 alpha subunit interaction interface [polypeptide binding]; other site 643867007140 Walker A motif; other site 643867007141 ATP binding site [chemical binding]; other site 643867007142 Walker B motif; other site 643867007143 inhibitor binding site; inhibition site 643867007144 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 643867007145 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 643867007146 active site 643867007147 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867007148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867007149 ATP binding site [chemical binding]; other site 643867007150 Mg2+ binding site [ion binding]; other site 643867007151 G-X-G motif; other site 643867007152 Domain of unknown function (DUF3244); Region: DUF3244; pfam11589 643867007153 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 643867007154 Cupin domain; Region: Cupin_2; cl17218 643867007155 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 643867007156 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 643867007157 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 643867007158 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 643867007159 Mg++ binding site [ion binding]; other site 643867007160 putative catalytic motif [active] 643867007161 substrate binding site [chemical binding]; other site 643867007162 O-Antigen ligase; Region: Wzy_C; pfam04932 643867007163 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 643867007164 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 643867007165 active site 643867007166 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867007167 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 643867007168 putative ADP-binding pocket [chemical binding]; other site 643867007169 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 643867007170 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 643867007171 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 643867007172 acyl-activating enzyme (AAE) consensus motif; other site 643867007173 acyl-activating enzyme (AAE) consensus motif; other site 643867007174 active site 643867007175 AMP binding site [chemical binding]; other site 643867007176 CoA binding site [chemical binding]; other site 643867007177 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 643867007178 AMP binding site [chemical binding]; other site 643867007179 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 643867007180 ParB-like nuclease domain; Region: ParB; smart00470 643867007181 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 643867007182 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 643867007183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 643867007184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867007185 homodimer interface [polypeptide binding]; other site 643867007186 catalytic residue [active] 643867007187 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 643867007188 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 643867007189 putative NAD(P) binding site [chemical binding]; other site 643867007190 active site 643867007191 putative substrate binding site [chemical binding]; other site 643867007192 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 643867007193 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 643867007194 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 643867007195 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 643867007196 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 643867007197 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 643867007198 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 643867007199 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 643867007200 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 643867007201 putative active site [active] 643867007202 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 643867007203 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 643867007204 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 643867007205 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 643867007206 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 643867007207 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 643867007208 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 643867007209 active site 643867007210 dimer interface [polypeptide binding]; other site 643867007211 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 643867007212 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 643867007213 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 643867007214 shikimate binding site; other site 643867007215 NAD(P) binding site [chemical binding]; other site 643867007216 Domain of unknown function (DUF368); Region: DUF368; pfam04018 643867007217 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 643867007218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867007219 TPR motif; other site 643867007220 binding surface 643867007221 TPR repeat; Region: TPR_11; pfam13414 643867007222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867007223 binding surface 643867007224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867007225 TPR motif; other site 643867007226 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867007227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867007228 binding surface 643867007229 TPR motif; other site 643867007230 TPR repeat; Region: TPR_11; pfam13414 643867007231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867007232 binding surface 643867007233 TPR motif; other site 643867007234 TPR repeat; Region: TPR_11; pfam13414 643867007235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867007236 binding surface 643867007237 Tetratricopeptide repeat; Region: TPR_16; pfam13432 643867007238 TPR motif; other site 643867007239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867007240 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 643867007241 NAD(P) binding site [chemical binding]; other site 643867007242 active site 643867007243 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 643867007244 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 643867007245 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 643867007246 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 643867007247 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 643867007248 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867007249 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 643867007250 putative ADP-binding pocket [chemical binding]; other site 643867007251 cytochrome c-550; Provisional; Region: psbV; cl17239 643867007252 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 643867007253 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 643867007254 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 643867007255 HflX GTPase family; Region: HflX; cd01878 643867007256 G1 box; other site 643867007257 GTP/Mg2+ binding site [chemical binding]; other site 643867007258 Switch I region; other site 643867007259 G2 box; other site 643867007260 G3 box; other site 643867007261 Switch II region; other site 643867007262 G4 box; other site 643867007263 G5 box; other site 643867007264 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 643867007265 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 643867007266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 643867007267 active site 643867007268 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 643867007269 SPFH domain / Band 7 family; Region: Band_7; pfam01145 643867007270 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 643867007271 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 643867007272 active site 643867007273 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 643867007274 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 643867007275 active site 643867007276 nucleotide binding site [chemical binding]; other site 643867007277 HIGH motif; other site 643867007278 KMSKS motif; other site 643867007279 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 643867007280 nudix motif; other site 643867007281 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 643867007282 nudix motif; other site 643867007283 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 643867007284 hypothetical protein; Provisional; Region: PRK06922 643867007285 Protein of unknown function, DUF; Region: DUF413; cl10479 643867007286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 643867007287 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 643867007288 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 643867007289 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 643867007290 Protein export membrane protein; Region: SecD_SecF; cl14618 643867007291 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 643867007292 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 643867007293 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867007294 Outer membrane efflux protein; Region: OEP; pfam02321 643867007295 Outer membrane efflux protein; Region: OEP; pfam02321 643867007296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867007297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 643867007298 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 643867007299 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 643867007300 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867007301 ligand binding site [chemical binding]; other site 643867007302 flexible hinge region; other site 643867007303 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 643867007304 putative switch regulator; other site 643867007305 non-specific DNA interactions [nucleotide binding]; other site 643867007306 DNA binding site [nucleotide binding] 643867007307 sequence specific DNA binding site [nucleotide binding]; other site 643867007308 putative cAMP binding site [chemical binding]; other site 643867007309 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 643867007310 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 643867007311 Multicopper oxidase; Region: Cu-oxidase; pfam00394 643867007312 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 643867007313 Cytochrome c; Region: Cytochrom_C; pfam00034 643867007314 Uncharacterized conserved protein [Function unknown]; Region: COG1262 643867007315 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 643867007316 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 643867007317 Cu(I) binding site [ion binding]; other site 643867007318 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 643867007319 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 643867007320 N-terminal plug; other site 643867007321 ligand-binding site [chemical binding]; other site 643867007322 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 643867007323 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 643867007324 Hemerythrin-like domain; Region: Hr-like; cd12108 643867007325 Fe binding site [ion binding]; other site 643867007326 Cytochrome c; Region: Cytochrom_C; pfam00034 643867007327 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 643867007328 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 643867007329 NosL; Region: NosL; cl01769 643867007330 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 643867007331 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 643867007332 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 643867007333 Walker A/P-loop; other site 643867007334 ATP binding site [chemical binding]; other site 643867007335 Q-loop/lid; other site 643867007336 ABC transporter signature motif; other site 643867007337 Walker B; other site 643867007338 D-loop; other site 643867007339 H-loop/switch region; other site 643867007340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867007341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867007342 dimer interface [polypeptide binding]; other site 643867007343 phosphorylation site [posttranslational modification] 643867007344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867007345 ATP binding site [chemical binding]; other site 643867007346 Mg2+ binding site [ion binding]; other site 643867007347 G-X-G motif; other site 643867007348 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 643867007349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867007350 active site 643867007351 phosphorylation site [posttranslational modification] 643867007352 intermolecular recognition site; other site 643867007353 dimerization interface [polypeptide binding]; other site 643867007354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867007355 Walker A motif; other site 643867007356 ATP binding site [chemical binding]; other site 643867007357 Walker B motif; other site 643867007358 arginine finger; other site 643867007359 Epoxide hydrolase N terminus; Region: EHN; pfam06441 643867007360 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 643867007361 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 643867007362 rod shape-determining protein MreB; Provisional; Region: PRK13930 643867007363 MreB and similar proteins; Region: MreB_like; cd10225 643867007364 nucleotide binding site [chemical binding]; other site 643867007365 Mg binding site [ion binding]; other site 643867007366 putative protofilament interaction site [polypeptide binding]; other site 643867007367 RodZ interaction site [polypeptide binding]; other site 643867007368 quinolinate synthetase; Provisional; Region: PRK09375 643867007369 L-aspartate oxidase; Provisional; Region: PRK06175 643867007370 L-aspartate oxidase; Provisional; Region: PRK08071 643867007371 Rrf2 family protein; Region: rrf2_super; TIGR00738 643867007372 Transcriptional regulator; Region: Rrf2; pfam02082 643867007373 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 643867007374 Low-spin heme binding site [chemical binding]; other site 643867007375 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 643867007376 D-pathway; other site 643867007377 Putative water exit pathway; other site 643867007378 Binuclear center (active site) [active] 643867007379 K-pathway; other site 643867007380 Putative proton exit pathway; other site 643867007381 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 643867007382 Cytochrome c; Region: Cytochrom_C; pfam00034 643867007383 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 643867007384 heme-binding site [chemical binding]; other site 643867007385 Predicted transcriptional regulator [Transcription]; Region: COG1959 643867007386 Transcriptional regulator; Region: Rrf2; pfam02082 643867007387 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 643867007388 active site 643867007389 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 643867007390 ATP cone domain; Region: ATP-cone; pfam03477 643867007391 Class III ribonucleotide reductase; Region: RNR_III; cd01675 643867007392 effector binding site; other site 643867007393 active site 643867007394 Zn binding site [ion binding]; other site 643867007395 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 643867007396 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 643867007397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 643867007398 FeS/SAM binding site; other site 643867007399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867007400 Walker A motif; other site 643867007401 ATP binding site [chemical binding]; other site 643867007402 Walker B motif; other site 643867007403 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 643867007404 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 643867007405 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 643867007406 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 643867007407 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 643867007408 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 643867007409 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 643867007410 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 643867007411 PAS domain; Region: PAS_10; pfam13596 643867007412 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 643867007413 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 643867007414 metal ion-dependent adhesion site (MIDAS); other site 643867007415 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 643867007416 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 643867007417 Walker A motif; other site 643867007418 ATP binding site [chemical binding]; other site 643867007419 Walker B motif; other site 643867007420 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 643867007421 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 643867007422 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 643867007423 Binuclear center (active site) [active] 643867007424 K-pathway; other site 643867007425 Putative proton exit pathway; other site 643867007426 Cytochrome c; Region: Cytochrom_C; pfam00034 643867007427 OsmC-like protein; Region: OsmC; cl00767 643867007428 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 643867007429 CoA binding domain; Region: CoA_binding_2; pfam13380 643867007430 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 643867007431 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 643867007432 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 643867007433 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 643867007434 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 643867007435 dimer interface [polypeptide binding]; other site 643867007436 putative metal binding site [ion binding]; other site 643867007437 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 643867007438 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 643867007439 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 643867007440 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 643867007441 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 643867007442 Cysteine-rich domain; Region: CCG; pfam02754 643867007443 Cysteine-rich domain; Region: CCG; pfam02754 643867007444 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 643867007445 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 643867007446 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 643867007447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867007448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867007449 dimer interface [polypeptide binding]; other site 643867007450 phosphorylation site [posttranslational modification] 643867007451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867007452 ATP binding site [chemical binding]; other site 643867007453 Mg2+ binding site [ion binding]; other site 643867007454 G-X-G motif; other site 643867007455 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 643867007456 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 643867007457 RNA binding surface [nucleotide binding]; other site 643867007458 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 643867007459 active site 643867007460 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 643867007461 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 643867007462 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 643867007463 EamA-like transporter family; Region: EamA; pfam00892 643867007464 EamA-like transporter family; Region: EamA; pfam00892 643867007465 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 643867007466 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 643867007467 FMN binding site [chemical binding]; other site 643867007468 active site 643867007469 catalytic residues [active] 643867007470 substrate binding site [chemical binding]; other site 643867007471 CAAX protease self-immunity; Region: Abi; pfam02517 643867007472 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 643867007473 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 643867007474 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 643867007475 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 643867007476 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 643867007477 NAD(P) binding site [chemical binding]; other site 643867007478 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 643867007479 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 643867007480 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 643867007481 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 643867007482 domain interfaces; other site 643867007483 active site 643867007484 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 643867007485 active site 643867007486 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 643867007487 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 643867007488 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 643867007489 NADP binding site [chemical binding]; other site 643867007490 active site 643867007491 putative substrate binding site [chemical binding]; other site 643867007492 VanW like protein; Region: VanW; pfam04294 643867007493 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 643867007494 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 643867007495 Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461 643867007496 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 643867007497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867007498 active site 643867007499 phosphorylation site [posttranslational modification] 643867007500 intermolecular recognition site; other site 643867007501 dimerization interface [polypeptide binding]; other site 643867007502 LytTr DNA-binding domain; Region: LytTR; smart00850 643867007503 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 643867007504 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 643867007505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 643867007506 Histidine kinase; Region: HisKA_2; pfam07568 643867007507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867007508 ATP binding site [chemical binding]; other site 643867007509 Mg2+ binding site [ion binding]; other site 643867007510 G-X-G motif; other site 643867007511 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 643867007512 active site 643867007513 ligand binding site [chemical binding]; other site 643867007514 NAD(P) binding site [chemical binding]; other site 643867007515 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 643867007516 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 643867007517 Substrate-binding site [chemical binding]; other site 643867007518 Substrate specificity [chemical binding]; other site 643867007519 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 643867007520 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 643867007521 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 643867007522 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 643867007523 HSP70 interaction site [polypeptide binding]; other site 643867007524 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 643867007525 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 643867007526 Peptidase family M28; Region: Peptidase_M28; pfam04389 643867007527 metal binding site [ion binding]; metal-binding site 643867007528 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867007529 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 643867007530 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 643867007531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 643867007532 seryl-tRNA synthetase; Provisional; Region: PRK05431 643867007533 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 643867007534 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 643867007535 dimer interface [polypeptide binding]; other site 643867007536 active site 643867007537 motif 1; other site 643867007538 motif 2; other site 643867007539 motif 3; other site 643867007540 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 643867007541 transcription termination factor Rho; Provisional; Region: PRK12608 643867007542 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 643867007543 RNA binding site [nucleotide binding]; other site 643867007544 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 643867007545 multimer interface [polypeptide binding]; other site 643867007546 Walker A motif; other site 643867007547 ATP binding site [chemical binding]; other site 643867007548 Walker B motif; other site 643867007549 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 643867007550 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 643867007551 oligomer interface [polypeptide binding]; other site 643867007552 metal binding site [ion binding]; metal-binding site 643867007553 metal binding site [ion binding]; metal-binding site 643867007554 Cl binding site [ion binding]; other site 643867007555 aspartate ring; other site 643867007556 basic sphincter; other site 643867007557 putative hydrophobic gate; other site 643867007558 periplasmic entrance; other site 643867007559 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 643867007560 putative SAM binding site [chemical binding]; other site 643867007561 homodimer interface [polypeptide binding]; other site 643867007562 S-adenosylmethionine synthetase; Validated; Region: PRK05250 643867007563 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 643867007564 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 643867007565 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 643867007566 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 643867007567 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 643867007568 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 643867007569 homodimer interface [polypeptide binding]; other site 643867007570 metal binding site [ion binding]; metal-binding site 643867007571 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 643867007572 homodimer interface [polypeptide binding]; other site 643867007573 active site 643867007574 putative chemical substrate binding site [chemical binding]; other site 643867007575 metal binding site [ion binding]; metal-binding site 643867007576 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 643867007577 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 643867007578 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 643867007579 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 643867007580 dimer interface [polypeptide binding]; other site 643867007581 substrate binding site [chemical binding]; other site 643867007582 metal binding sites [ion binding]; metal-binding site 643867007583 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 643867007584 Mechanosensitive ion channel; Region: MS_channel; pfam00924 643867007585 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 643867007586 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867007587 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 643867007588 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867007589 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867007590 MoxR-like ATPases [General function prediction only]; Region: COG0714 643867007591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867007592 Walker A motif; other site 643867007593 ATP binding site [chemical binding]; other site 643867007594 Walker B motif; other site 643867007595 arginine finger; other site 643867007596 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 643867007597 active site 643867007598 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 643867007599 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 643867007600 tetramer interface [polypeptide binding]; other site 643867007601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867007602 catalytic residue [active] 643867007603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 643867007604 Coenzyme A binding pocket [chemical binding]; other site 643867007605 Predicted amidohydrolase [General function prediction only]; Region: COG0388 643867007606 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 643867007607 putative active site [active] 643867007608 catalytic triad [active] 643867007609 putative dimer interface [polypeptide binding]; other site 643867007610 lipoyl synthase; Provisional; Region: PRK05481 643867007611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 643867007612 FeS/SAM binding site; other site 643867007613 OsmC-like protein; Region: OsmC; pfam02566 643867007614 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 643867007615 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 643867007616 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 643867007617 tetramer interface [polypeptide binding]; other site 643867007618 TPP-binding site [chemical binding]; other site 643867007619 heterodimer interface [polypeptide binding]; other site 643867007620 phosphorylation loop region [posttranslational modification] 643867007621 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 643867007622 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 643867007623 alpha subunit interface [polypeptide binding]; other site 643867007624 TPP binding site [chemical binding]; other site 643867007625 heterodimer interface [polypeptide binding]; other site 643867007626 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 643867007627 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 643867007628 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 643867007629 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 643867007630 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 643867007631 homotrimer interaction site [polypeptide binding]; other site 643867007632 zinc binding site [ion binding]; other site 643867007633 CDP-binding sites; other site 643867007634 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 643867007635 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 643867007636 agmatinase; Region: agmatinase; TIGR01230 643867007637 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 643867007638 putative active site [active] 643867007639 putative metal binding site [ion binding]; other site 643867007640 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 643867007641 Na2 binding site [ion binding]; other site 643867007642 putative substrate binding site 1 [chemical binding]; other site 643867007643 Na binding site 1 [ion binding]; other site 643867007644 putative substrate binding site 2 [chemical binding]; other site 643867007645 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 643867007646 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 643867007647 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 643867007648 dimer interface [polypeptide binding]; other site 643867007649 catalytic triad [active] 643867007650 peroxidatic and resolving cysteines [active] 643867007651 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 643867007652 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 643867007653 NAD binding site [chemical binding]; other site 643867007654 catalytic residues [active] 643867007655 short chain dehydrogenase; Provisional; Region: PRK08339 643867007656 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 643867007657 putative NAD(P) binding site [chemical binding]; other site 643867007658 putative active site [active] 643867007659 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 643867007660 Amidohydrolase; Region: Amidohydro_2; pfam04909 643867007661 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 643867007662 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 643867007663 DNA binding site [nucleotide binding] 643867007664 active site 643867007665 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 643867007666 kynureninase; Region: kynureninase; TIGR01814 643867007667 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 643867007668 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 643867007669 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 643867007670 Ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which varies in orientation with respect to the NAD(P) binding domain. The N-terminal region...; Region: FNR_like_1; cd06196 643867007671 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 643867007672 FAD binding pocket [chemical binding]; other site 643867007673 FAD binding motif [chemical binding]; other site 643867007674 phosphate binding motif [ion binding]; other site 643867007675 beta-alpha-beta structure motif; other site 643867007676 NAD binding pocket [chemical binding]; other site 643867007677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867007678 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 643867007679 NAD(P) binding site [chemical binding]; other site 643867007680 active site 643867007681 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 643867007682 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867007683 ligand binding site [chemical binding]; other site 643867007684 flexible hinge region; other site 643867007685 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 643867007686 putative switch regulator; other site 643867007687 non-specific DNA interactions [nucleotide binding]; other site 643867007688 DNA binding site [nucleotide binding] 643867007689 sequence specific DNA binding site [nucleotide binding]; other site 643867007690 putative cAMP binding site [chemical binding]; other site 643867007691 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 643867007692 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 643867007693 FeS/SAM binding site; other site 643867007694 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 643867007695 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 643867007696 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 643867007697 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 643867007698 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 643867007699 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867007700 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 643867007701 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 643867007702 N-terminal plug; other site 643867007703 ligand-binding site [chemical binding]; other site 643867007704 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 643867007705 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 643867007706 G1 box; other site 643867007707 putative GEF interaction site [polypeptide binding]; other site 643867007708 GTP/Mg2+ binding site [chemical binding]; other site 643867007709 Switch I region; other site 643867007710 G2 box; other site 643867007711 G3 box; other site 643867007712 Switch II region; other site 643867007713 G4 box; other site 643867007714 G5 box; other site 643867007715 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 643867007716 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 643867007717 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 643867007718 nucleotide binding site [chemical binding]; other site 643867007719 substrate binding site [chemical binding]; other site 643867007720 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 643867007721 AMP binding site [chemical binding]; other site 643867007722 metal binding site [ion binding]; metal-binding site 643867007723 active site 643867007724 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 643867007725 G1 box; other site 643867007726 GTP/Mg2+ binding site [chemical binding]; other site 643867007727 Switch I region; other site 643867007728 G2 box; other site 643867007729 G3 box; other site 643867007730 Switch II region; other site 643867007731 G4 box; other site 643867007732 G5 box; other site 643867007733 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 643867007734 substrate binding site; other site 643867007735 dimer interface; other site 643867007736 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 643867007737 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 643867007738 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 643867007739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867007740 Walker A/P-loop; other site 643867007741 ATP binding site [chemical binding]; other site 643867007742 Q-loop/lid; other site 643867007743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 643867007744 ABC transporter; Region: ABC_tran_2; pfam12848 643867007745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 643867007746 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 643867007747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 643867007748 active site 643867007749 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 643867007750 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 643867007751 active site 643867007752 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 643867007753 Asp-box motif; other site 643867007754 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 643867007755 Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240 643867007756 Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240 643867007757 Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240 643867007758 Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240 643867007759 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867007760 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 643867007761 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 643867007762 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 643867007763 putative catalytic residues [active] 643867007764 putative nucleotide binding site [chemical binding]; other site 643867007765 putative aspartate binding site [chemical binding]; other site 643867007766 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 643867007767 dimer interface [polypeptide binding]; other site 643867007768 putative threonine allosteric regulatory site; other site 643867007769 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 643867007770 putative threonine allosteric regulatory site; other site 643867007771 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 643867007772 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 643867007773 homoserine kinase; Provisional; Region: PRK01212 643867007774 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 643867007775 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 643867007776 threonine synthase; Validated; Region: PRK09225 643867007777 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 643867007778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867007779 catalytic residue [active] 643867007780 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 643867007781 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 643867007782 active site 643867007783 phosphodiesterase; Provisional; Region: PRK12704 643867007784 KH domain; Region: KH_1; pfam00013 643867007785 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 643867007786 Zn2+ binding site [ion binding]; other site 643867007787 Mg2+ binding site [ion binding]; other site 643867007788 Cell division protein ZapA; Region: ZapA; pfam05164 643867007789 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 643867007790 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 643867007791 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 643867007792 putative tRNA-binding site [nucleotide binding]; other site 643867007793 B3/4 domain; Region: B3_4; pfam03483 643867007794 tRNA synthetase B5 domain; Region: B5; smart00874 643867007795 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 643867007796 dimer interface [polypeptide binding]; other site 643867007797 motif 1; other site 643867007798 motif 3; other site 643867007799 motif 2; other site 643867007800 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 643867007801 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 643867007802 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 643867007803 RIP metalloprotease RseP; Region: TIGR00054 643867007804 active site 643867007805 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 643867007806 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 643867007807 protein binding site [polypeptide binding]; other site 643867007808 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 643867007809 putative substrate binding region [chemical binding]; other site 643867007810 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 643867007811 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 643867007812 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 643867007813 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 643867007814 GH3 auxin-responsive promoter; Region: GH3; pfam03321 643867007815 GTP-binding protein LepA; Provisional; Region: PRK05433 643867007816 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 643867007817 G1 box; other site 643867007818 putative GEF interaction site [polypeptide binding]; other site 643867007819 GTP/Mg2+ binding site [chemical binding]; other site 643867007820 Switch I region; other site 643867007821 G2 box; other site 643867007822 G3 box; other site 643867007823 Switch II region; other site 643867007824 G4 box; other site 643867007825 G5 box; other site 643867007826 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 643867007827 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 643867007828 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 643867007829 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 643867007830 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 643867007831 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 643867007832 homodimer interface [polypeptide binding]; other site 643867007833 NADP binding site [chemical binding]; other site 643867007834 substrate binding site [chemical binding]; other site 643867007835 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 643867007836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 643867007837 FeS/SAM binding site; other site 643867007838 TPR repeat; Region: TPR_11; pfam13414 643867007839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867007840 binding surface 643867007841 TPR motif; other site 643867007842 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867007843 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867007844 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867007845 ligand binding site [chemical binding]; other site 643867007846 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 643867007847 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867007848 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 643867007849 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867007850 starch binding outer membrane protein SusD; Region: SusD; cl17845 643867007851 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 643867007852 active site 643867007853 Family description; Region: VCBS; pfam13517 643867007854 Family description; Region: VCBS; pfam13517 643867007855 Family description; Region: VCBS; pfam13517 643867007856 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 643867007857 Family description; Region: VCBS; pfam13517 643867007858 Family description; Region: VCBS; pfam13517 643867007859 Family description; Region: VCBS; pfam13517 643867007860 Family description; Region: VCBS; pfam13517 643867007861 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867007862 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867007863 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 643867007864 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 643867007865 starch binding outer membrane protein SusD; Region: SusD; cd08977 643867007866 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 643867007867 GTP-binding protein YchF; Reviewed; Region: PRK09601 643867007868 YchF GTPase; Region: YchF; cd01900 643867007869 G1 box; other site 643867007870 GTP/Mg2+ binding site [chemical binding]; other site 643867007871 Switch I region; other site 643867007872 G2 box; other site 643867007873 Switch II region; other site 643867007874 G3 box; other site 643867007875 G4 box; other site 643867007876 G5 box; other site 643867007877 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 643867007878 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 643867007879 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 643867007880 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 643867007881 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867007882 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867007883 DNA binding residues [nucleotide binding] 643867007884 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867007885 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 643867007886 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 643867007887 starch binding outer membrane protein SusD; Region: SusD; cd08977 643867007888 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 643867007889 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867007890 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 643867007891 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867007892 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 643867007893 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 643867007894 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 643867007895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 643867007896 motif II; other site 643867007897 BCCT family transporter; Region: BCCT; pfam02028 643867007898 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867007899 Ligand Binding Site [chemical binding]; other site 643867007900 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 643867007901 DNA protecting protein DprA; Region: dprA; TIGR00732 643867007902 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 643867007903 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 643867007904 DNA binding residues [nucleotide binding] 643867007905 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 643867007906 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 643867007907 putative active site [active] 643867007908 putative metal binding site [ion binding]; other site 643867007909 TraB family; Region: TraB; cl12050 643867007910 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 643867007911 Peptidase family M23; Region: Peptidase_M23; pfam01551 643867007912 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 643867007913 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 643867007914 motif 1; other site 643867007915 active site 643867007916 motif 2; other site 643867007917 motif 3; other site 643867007918 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 643867007919 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 643867007920 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 643867007921 GatB domain; Region: GatB_Yqey; smart00845 643867007922 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 643867007923 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 643867007924 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867007925 catalytic residues [active] 643867007926 PAS domain S-box; Region: sensory_box; TIGR00229 643867007927 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867007928 putative active site [active] 643867007929 heme pocket [chemical binding]; other site 643867007930 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867007931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867007932 ATP binding site [chemical binding]; other site 643867007933 Mg2+ binding site [ion binding]; other site 643867007934 G-X-G motif; other site 643867007935 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 643867007936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867007937 non-specific DNA binding site [nucleotide binding]; other site 643867007938 salt bridge; other site 643867007939 sequence-specific DNA binding site [nucleotide binding]; other site 643867007940 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867007941 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867007942 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867007943 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867007944 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 643867007945 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 643867007946 Active site serine [active] 643867007947 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 643867007948 Tetratricopeptide repeat; Region: TPR_16; pfam13432 643867007949 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867007950 TPR motif; other site 643867007951 binding surface 643867007952 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867007953 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867007954 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867007955 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867007956 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867007957 ligand binding site [chemical binding]; other site 643867007958 Protein of unknown function DUF86; Region: DUF86; cl01031 643867007959 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 643867007960 active site 643867007961 NTP binding site [chemical binding]; other site 643867007962 metal binding triad [ion binding]; metal-binding site 643867007963 antibiotic binding site [chemical binding]; other site 643867007964 Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171 643867007965 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 643867007966 Beta-lactamase; Region: Beta-lactamase; pfam00144 643867007967 short chain dehydrogenase; Provisional; Region: PRK06197 643867007968 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 643867007969 putative NAD(P) binding site [chemical binding]; other site 643867007970 active site 643867007971 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 643867007972 Takusan; Region: Takusan; pfam04822 643867007973 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 643867007974 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 643867007975 GAF domain; Region: GAF; pfam01590 643867007976 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 643867007977 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 643867007978 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 643867007979 putative metal binding site [ion binding]; other site 643867007980 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 643867007981 Interdomain contacts; other site 643867007982 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 643867007983 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 643867007984 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 643867007985 catalytic residues [active] 643867007986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867007987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867007988 ATP binding site [chemical binding]; other site 643867007989 Mg2+ binding site [ion binding]; other site 643867007990 G-X-G motif; other site 643867007991 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 643867007992 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 643867007993 DNA binding site [nucleotide binding] 643867007994 active site 643867007995 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 643867007996 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 643867007997 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 643867007998 Na binding site [ion binding]; other site 643867007999 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 643867008000 recombination protein RecR; Reviewed; Region: recR; PRK00076 643867008001 RecR protein; Region: RecR; pfam02132 643867008002 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 643867008003 putative active site [active] 643867008004 putative metal-binding site [ion binding]; other site 643867008005 tetramer interface [polypeptide binding]; other site 643867008006 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 643867008007 putative active site [active] 643867008008 Zn binding site [ion binding]; other site 643867008009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867008010 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 643867008011 NAD(P) binding site [chemical binding]; other site 643867008012 active site 643867008013 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 643867008014 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 643867008015 tRNA; other site 643867008016 putative tRNA binding site [nucleotide binding]; other site 643867008017 putative NADP binding site [chemical binding]; other site 643867008018 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 643867008019 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867008020 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 643867008021 Peptidase family M23; Region: Peptidase_M23; pfam01551 643867008022 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 643867008023 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 643867008024 catalytic residues [active] 643867008025 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 643867008026 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 643867008027 dimer interface [polypeptide binding]; other site 643867008028 anticodon binding site; other site 643867008029 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 643867008030 homodimer interface [polypeptide binding]; other site 643867008031 motif 1; other site 643867008032 active site 643867008033 motif 2; other site 643867008034 GAD domain; Region: GAD; pfam02938 643867008035 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 643867008036 motif 3; other site 643867008037 ZIP Zinc transporter; Region: Zip; pfam02535 643867008038 Methyltransferase domain; Region: Methyltransf_31; pfam13847 643867008039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867008040 S-adenosylmethionine binding site [chemical binding]; other site 643867008041 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 643867008042 ApbE family; Region: ApbE; pfam02424 643867008043 Oxygen tolerance; Region: BatD; pfam13584 643867008044 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 643867008045 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 643867008046 Tetramer interface [polypeptide binding]; other site 643867008047 active site 643867008048 FMN-binding site [chemical binding]; other site 643867008049 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 643867008050 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 643867008051 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 643867008052 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 643867008053 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 643867008054 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 643867008055 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 643867008056 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 643867008057 putative metal binding site [ion binding]; other site 643867008058 Divergent AAA domain; Region: AAA_4; pfam04326 643867008059 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 643867008060 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867008061 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 643867008062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867008063 S-adenosylmethionine binding site [chemical binding]; other site 643867008064 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 643867008065 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 643867008066 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867008067 FtsX-like permease family; Region: FtsX; pfam02687 643867008068 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 643867008069 nucleoside/Zn binding site; other site 643867008070 dimer interface [polypeptide binding]; other site 643867008071 catalytic motif [active] 643867008072 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 643867008073 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 643867008074 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 643867008075 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 643867008076 Family description; Region: VCBS; pfam13517 643867008077 Family description; Region: VCBS; pfam13517 643867008078 Family description; Region: VCBS; pfam13517 643867008079 Family description; Region: VCBS; pfam13517 643867008080 IPT/TIG domain; Region: TIG; pfam01833 643867008081 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867008082 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867008083 IPT/TIG domain; Region: TIG; pfam01833 643867008084 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867008085 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 643867008086 putative active site [active] 643867008087 putative CoA binding site [chemical binding]; other site 643867008088 nudix motif; other site 643867008089 metal binding site [ion binding]; metal-binding site 643867008090 Protein of unknown function (DUF819); Region: DUF819; cl02317 643867008091 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 643867008092 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 643867008093 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 643867008094 homodimer interface [polypeptide binding]; other site 643867008095 substrate-cofactor binding pocket; other site 643867008096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867008097 catalytic residue [active] 643867008098 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 643867008099 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 643867008100 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 643867008101 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 643867008102 active site 643867008103 SAM binding site [chemical binding]; other site 643867008104 homodimer interface [polypeptide binding]; other site 643867008105 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 643867008106 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 643867008107 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 643867008108 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 643867008109 Active Sites [active] 643867008110 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867008111 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867008112 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867008113 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867008114 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867008115 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867008116 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867008117 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867008118 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867008119 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867008120 Family description; Region: VCBS; pfam13517 643867008121 Family description; Region: VCBS; pfam13517 643867008122 Family description; Region: VCBS; pfam13517 643867008123 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867008124 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 643867008125 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867008126 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867008127 ligand binding site [chemical binding]; other site 643867008128 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 643867008129 Interdomain contacts; other site 643867008130 Cytokine receptor motif; other site 643867008131 AAA domain; Region: AAA_14; pfam13173 643867008132 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 643867008133 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 643867008134 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 643867008135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867008136 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 643867008137 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 643867008138 active site 643867008139 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 643867008140 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 643867008141 Ligand binding site; other site 643867008142 Putative Catalytic site; other site 643867008143 DXD motif; other site 643867008144 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 643867008145 dihydroorotase; Validated; Region: pyrC; PRK09357 643867008146 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 643867008147 active site 643867008148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 643867008149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 643867008150 Bacterial transcriptional repressor; Region: TetR; pfam13972 643867008151 hypothetical protein; Provisional; Region: PRK06753 643867008152 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 643867008153 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867008154 ribosome recycling factor; Reviewed; Region: frr; PRK00083 643867008155 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 643867008156 hinge region; other site 643867008157 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 643867008158 putative nucleotide binding site [chemical binding]; other site 643867008159 uridine monophosphate binding site [chemical binding]; other site 643867008160 homohexameric interface [polypeptide binding]; other site 643867008161 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 643867008162 carboxyltransferase (CT) interaction site; other site 643867008163 biotinylation site [posttranslational modification]; other site 643867008164 elongation factor Tu; Reviewed; Region: PRK12735 643867008165 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 643867008166 G1 box; other site 643867008167 GEF interaction site [polypeptide binding]; other site 643867008168 GTP/Mg2+ binding site [chemical binding]; other site 643867008169 Switch I region; other site 643867008170 G2 box; other site 643867008171 G3 box; other site 643867008172 Switch II region; other site 643867008173 G4 box; other site 643867008174 G5 box; other site 643867008175 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 643867008176 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 643867008177 Antibiotic Binding Site [chemical binding]; other site 643867008178 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 643867008179 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 643867008180 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 643867008181 putative homodimer interface [polypeptide binding]; other site 643867008182 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 643867008183 heterodimer interface [polypeptide binding]; other site 643867008184 homodimer interface [polypeptide binding]; other site 643867008185 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 643867008186 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 643867008187 23S rRNA interface [nucleotide binding]; other site 643867008188 L7/L12 interface [polypeptide binding]; other site 643867008189 putative thiostrepton binding site; other site 643867008190 L25 interface [polypeptide binding]; other site 643867008191 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 643867008192 mRNA/rRNA interface [nucleotide binding]; other site 643867008193 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 643867008194 23S rRNA interface [nucleotide binding]; other site 643867008195 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 643867008196 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 643867008197 core dimer interface [polypeptide binding]; other site 643867008198 peripheral dimer interface [polypeptide binding]; other site 643867008199 L10 interface [polypeptide binding]; other site 643867008200 L11 interface [polypeptide binding]; other site 643867008201 putative EF-Tu interaction site [polypeptide binding]; other site 643867008202 putative EF-G interaction site [polypeptide binding]; other site 643867008203 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 643867008204 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 643867008205 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 643867008206 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 643867008207 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 643867008208 RPB12 interaction site [polypeptide binding]; other site 643867008209 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 643867008210 RPB3 interaction site [polypeptide binding]; other site 643867008211 RPB1 interaction site [polypeptide binding]; other site 643867008212 RPB11 interaction site [polypeptide binding]; other site 643867008213 RPB10 interaction site [polypeptide binding]; other site 643867008214 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 643867008215 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 643867008216 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 643867008217 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 643867008218 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 643867008219 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 643867008220 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 643867008221 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 643867008222 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 643867008223 DNA binding site [nucleotide binding] 643867008224 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 643867008225 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 643867008226 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 643867008227 S17 interaction site [polypeptide binding]; other site 643867008228 S8 interaction site; other site 643867008229 16S rRNA interaction site [nucleotide binding]; other site 643867008230 streptomycin interaction site [chemical binding]; other site 643867008231 23S rRNA interaction site [nucleotide binding]; other site 643867008232 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 643867008233 30S ribosomal protein S7; Validated; Region: PRK05302 643867008234 elongation factor G; Reviewed; Region: PRK12739 643867008235 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 643867008236 G1 box; other site 643867008237 putative GEF interaction site [polypeptide binding]; other site 643867008238 GTP/Mg2+ binding site [chemical binding]; other site 643867008239 Switch I region; other site 643867008240 G2 box; other site 643867008241 G3 box; other site 643867008242 Switch II region; other site 643867008243 G4 box; other site 643867008244 G5 box; other site 643867008245 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 643867008246 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 643867008247 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 643867008248 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 643867008249 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 643867008250 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 643867008251 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 643867008252 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 643867008253 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 643867008254 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 643867008255 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 643867008256 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 643867008257 putative translocon binding site; other site 643867008258 protein-rRNA interface [nucleotide binding]; other site 643867008259 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 643867008260 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 643867008261 G-X-X-G motif; other site 643867008262 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 643867008263 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 643867008264 23S rRNA interface [nucleotide binding]; other site 643867008265 5S rRNA interface [nucleotide binding]; other site 643867008266 putative antibiotic binding site [chemical binding]; other site 643867008267 L25 interface [polypeptide binding]; other site 643867008268 L27 interface [polypeptide binding]; other site 643867008269 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 643867008270 23S rRNA interface [nucleotide binding]; other site 643867008271 putative translocon interaction site; other site 643867008272 signal recognition particle (SRP54) interaction site; other site 643867008273 L23 interface [polypeptide binding]; other site 643867008274 trigger factor interaction site; other site 643867008275 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 643867008276 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 643867008277 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 643867008278 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 643867008279 RNA binding site [nucleotide binding]; other site 643867008280 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 643867008281 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 643867008282 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 643867008283 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 643867008284 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 643867008285 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 643867008286 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 643867008287 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 643867008288 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 643867008289 23S rRNA interface [nucleotide binding]; other site 643867008290 L21e interface [polypeptide binding]; other site 643867008291 5S rRNA interface [nucleotide binding]; other site 643867008292 L27 interface [polypeptide binding]; other site 643867008293 L5 interface [polypeptide binding]; other site 643867008294 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 643867008295 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 643867008296 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 643867008297 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 643867008298 23S rRNA binding site [nucleotide binding]; other site 643867008299 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 643867008300 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 643867008301 SecY translocase; Region: SecY; pfam00344 643867008302 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 643867008303 rRNA binding site [nucleotide binding]; other site 643867008304 predicted 30S ribosome binding site; other site 643867008305 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 643867008306 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 643867008307 30S ribosomal protein S13; Region: bact_S13; TIGR03631 643867008308 30S ribosomal protein S11; Validated; Region: PRK05309 643867008309 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 643867008310 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 643867008311 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 643867008312 RNA binding surface [nucleotide binding]; other site 643867008313 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 643867008314 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 643867008315 alphaNTD - beta interaction site [polypeptide binding]; other site 643867008316 alphaNTD homodimer interface [polypeptide binding]; other site 643867008317 alphaNTD - beta' interaction site [polypeptide binding]; other site 643867008318 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 643867008319 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 643867008320 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 643867008321 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 643867008322 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 643867008323 catalytic site [active] 643867008324 subunit interface [polypeptide binding]; other site 643867008325 enolase; Provisional; Region: eno; PRK00077 643867008326 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 643867008327 dimer interface [polypeptide binding]; other site 643867008328 metal binding site [ion binding]; metal-binding site 643867008329 substrate binding pocket [chemical binding]; other site 643867008330 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 643867008331 exopolyphosphatase; Region: exo_poly_only; TIGR03706 643867008332 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 643867008333 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 643867008334 tol-pal system protein YbgF; Provisional; Region: PRK10803 643867008335 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 643867008336 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 643867008337 MepB protein; Region: MepB; cl01985 643867008338 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 643867008339 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 643867008340 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 643867008341 active site 643867008342 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 643867008343 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 643867008344 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 643867008345 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 643867008346 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 643867008347 active site 643867008348 dimer interface [polypeptide binding]; other site 643867008349 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 643867008350 Ligand Binding Site [chemical binding]; other site 643867008351 Molecular Tunnel; other site 643867008352 Transposase; Region: DEDD_Tnp_IS110; pfam01548 643867008353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 643867008354 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 643867008355 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 643867008356 nudix motif; other site 643867008357 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 643867008358 6-phosphofructokinase; Provisional; Region: PRK03202 643867008359 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 643867008360 active site 643867008361 ADP/pyrophosphate binding site [chemical binding]; other site 643867008362 dimerization interface [polypeptide binding]; other site 643867008363 allosteric effector site; other site 643867008364 fructose-1,6-bisphosphate binding site; other site 643867008365 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 643867008366 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 643867008367 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 643867008368 nucleotide binding site [chemical binding]; other site 643867008369 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 643867008370 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 643867008371 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 643867008372 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 643867008373 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867008374 catalytic residue [active] 643867008375 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867008376 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867008377 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867008378 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 643867008379 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 643867008380 protein binding site [polypeptide binding]; other site 643867008381 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 643867008382 protein binding site [polypeptide binding]; other site 643867008383 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 643867008384 Zn binding site [ion binding]; other site 643867008385 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 643867008386 hypothetical protein; Reviewed; Region: PRK00024 643867008387 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 643867008388 MPN+ (JAMM) motif; other site 643867008389 Zinc-binding site [ion binding]; other site 643867008390 PAS domain S-box; Region: sensory_box; TIGR00229 643867008391 PAS domain; Region: PAS_9; pfam13426 643867008392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867008393 putative active site [active] 643867008394 heme pocket [chemical binding]; other site 643867008395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867008396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867008397 phosphorylation site [posttranslational modification] 643867008398 dimer interface [polypeptide binding]; other site 643867008399 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 643867008400 Transcriptional regulators [Transcription]; Region: MarR; COG1846 643867008401 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 643867008402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867008403 TPR motif; other site 643867008404 binding surface 643867008405 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867008406 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867008407 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 643867008408 2TM domain; Region: 2TM; pfam13239 643867008409 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867008410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867008411 TPR motif; other site 643867008412 binding surface 643867008413 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867008414 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867008415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867008416 binding surface 643867008417 TPR motif; other site 643867008418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867008419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867008420 ATP binding site [chemical binding]; other site 643867008421 Mg2+ binding site [ion binding]; other site 643867008422 G-X-G motif; other site 643867008423 outer membrane porin, OprD family; Region: OprD; pfam03573 643867008424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 643867008425 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 643867008426 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 643867008427 active site residue [active] 643867008428 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867008429 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 643867008430 ligand binding site [chemical binding]; other site 643867008431 flexible hinge region; other site 643867008432 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 643867008433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 643867008434 dimerization interface [polypeptide binding]; other site 643867008435 putative DNA binding site [nucleotide binding]; other site 643867008436 putative Zn2+ binding site [ion binding]; other site 643867008437 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 643867008438 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 643867008439 metal-binding site [ion binding] 643867008440 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 643867008441 Soluble P-type ATPase [General function prediction only]; Region: COG4087 643867008442 Predicted flavoprotein [General function prediction only]; Region: COG0431 643867008443 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 643867008444 YceI-like domain; Region: YceI; pfam04264 643867008445 purine nucleoside phosphorylase; Provisional; Region: PRK08202 643867008446 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 643867008447 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 643867008448 putative ADP-ribose binding site [chemical binding]; other site 643867008449 putative active site [active] 643867008450 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 643867008451 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 643867008452 active site 643867008453 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 643867008454 Isochorismatase family; Region: Isochorismatase; pfam00857 643867008455 catalytic triad [active] 643867008456 metal binding site [ion binding]; metal-binding site 643867008457 conserved cis-peptide bond; other site 643867008458 Outer membrane efflux protein; Region: OEP; pfam02321 643867008459 Outer membrane efflux protein; Region: OEP; pfam02321 643867008460 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867008461 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 643867008462 FtsX-like permease family; Region: FtsX; pfam02687 643867008463 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 643867008464 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867008465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867008466 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867008467 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 643867008468 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867008469 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867008470 Fasciclin domain; Region: Fasciclin; pfam02469 643867008471 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts; Region: FAS1; smart00554 643867008472 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 643867008473 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 643867008474 active site 643867008475 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 643867008476 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 643867008477 Glutamate binding site [chemical binding]; other site 643867008478 NAD binding site [chemical binding]; other site 643867008479 catalytic residues [active] 643867008480 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 643867008481 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 643867008482 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 643867008483 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 643867008484 putative active site [active] 643867008485 putative metal binding site [ion binding]; other site 643867008486 Protein of unknown function, DUF481; Region: DUF481; cl01213 643867008487 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 643867008488 DNA polymerase III subunit delta'; Validated; Region: PRK05564 643867008489 DNA polymerase III subunit delta'; Validated; Region: PRK08485 643867008490 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 643867008491 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 643867008492 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 643867008493 dimer interface [polypeptide binding]; other site 643867008494 active site 643867008495 glycine-pyridoxal phosphate binding site [chemical binding]; other site 643867008496 folate binding site [chemical binding]; other site 643867008497 NUMOD4 motif; Region: NUMOD4; pfam07463 643867008498 HNH endonuclease; Region: HNH_3; pfam13392 643867008499 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 643867008500 DNA-binding interface [nucleotide binding]; DNA binding site 643867008501 recombination factor protein RarA; Reviewed; Region: PRK13342 643867008502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867008503 Walker A motif; other site 643867008504 ATP binding site [chemical binding]; other site 643867008505 Walker B motif; other site 643867008506 arginine finger; other site 643867008507 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 643867008508 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 643867008509 EamA-like transporter family; Region: EamA; pfam00892 643867008510 EamA-like transporter family; Region: EamA; pfam00892 643867008511 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 643867008512 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 643867008513 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 643867008514 GTPase RsgA; Reviewed; Region: PRK00098 643867008515 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 643867008516 RNA binding site [nucleotide binding]; other site 643867008517 homodimer interface [polypeptide binding]; other site 643867008518 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 643867008519 GTPase/Zn-binding domain interface [polypeptide binding]; other site 643867008520 GTP/Mg2+ binding site [chemical binding]; other site 643867008521 G4 box; other site 643867008522 G5 box; other site 643867008523 G1 box; other site 643867008524 Switch I region; other site 643867008525 G2 box; other site 643867008526 G3 box; other site 643867008527 Switch II region; other site 643867008528 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 643867008529 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 643867008530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 643867008531 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 643867008532 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 643867008533 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 643867008534 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 643867008535 Family description; Region: VCBS; pfam13517 643867008536 Family description; Region: VCBS; pfam13517 643867008537 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867008538 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867008539 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 643867008540 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 643867008541 Family description; Region: VCBS; pfam13517 643867008542 Family description; Region: VCBS; pfam13517 643867008543 Family description; Region: VCBS; pfam13517 643867008544 Family description; Region: VCBS; pfam13517 643867008545 Family description; Region: VCBS; pfam13517 643867008546 Family description; Region: VCBS; pfam13517 643867008547 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867008548 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867008549 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867008550 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 643867008551 Clp amino terminal domain; Region: Clp_N; pfam02861 643867008552 Clp amino terminal domain; Region: Clp_N; pfam02861 643867008553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867008554 Walker A motif; other site 643867008555 ATP binding site [chemical binding]; other site 643867008556 Walker B motif; other site 643867008557 arginine finger; other site 643867008558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867008559 Walker A motif; other site 643867008560 ATP binding site [chemical binding]; other site 643867008561 Walker B motif; other site 643867008562 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 643867008563 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 643867008564 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 643867008565 active site 643867008566 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867008567 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867008568 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 643867008569 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867008570 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 643867008571 Peptidase family M48; Region: Peptidase_M48; pfam01435 643867008572 TPR repeat; Region: TPR_11; pfam13414 643867008573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867008574 binding surface 643867008575 TPR motif; other site 643867008576 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867008577 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867008578 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867008579 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867008580 ligand binding site [chemical binding]; other site 643867008581 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 643867008582 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 643867008583 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 643867008584 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 643867008585 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 643867008586 Domain of unknown function (DUF955); Region: DUF955; cl01076 643867008587 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 643867008588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867008589 non-specific DNA binding site [nucleotide binding]; other site 643867008590 salt bridge; other site 643867008591 sequence-specific DNA binding site [nucleotide binding]; other site 643867008592 Bacterial SH3 domain; Region: SH3_3; pfam08239 643867008593 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 643867008594 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 643867008595 active site 643867008596 catalytic tetrad [active] 643867008597 Protein of unknown function (DUF418); Region: DUF418; cl12135 643867008598 Protein of unknown function (DUF418); Region: DUF418; pfam04235 643867008599 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 643867008600 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 643867008601 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 643867008602 catalytic site [active] 643867008603 Helix-turn-helix domain; Region: HTH_18; pfam12833 643867008604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 643867008605 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 643867008606 Response regulator receiver domain; Region: Response_reg; pfam00072 643867008607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867008608 active site 643867008609 phosphorylation site [posttranslational modification] 643867008610 intermolecular recognition site; other site 643867008611 dimerization interface [polypeptide binding]; other site 643867008612 Family description; Region: VCBS; pfam13517 643867008613 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 643867008614 Family description; Region: VCBS; pfam13517 643867008615 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 643867008616 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867008617 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867008618 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 643867008619 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867008620 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 643867008621 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 643867008622 nucleotide binding site/active site [active] 643867008623 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 643867008624 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 643867008625 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 643867008626 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 643867008627 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 643867008628 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 643867008629 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 643867008630 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 643867008631 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 643867008632 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 643867008633 putative ligand binding site [chemical binding]; other site 643867008634 putative NAD binding site [chemical binding]; other site 643867008635 catalytic site [active] 643867008636 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 643867008637 MgtE intracellular N domain; Region: MgtE_N; pfam03448 643867008638 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 643867008639 Divalent cation transporter; Region: MgtE; pfam01769 643867008640 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 643867008641 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 643867008642 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 643867008643 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 643867008644 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 643867008645 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 643867008646 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 643867008647 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 643867008648 dimer interface [polypeptide binding]; other site 643867008649 active site 643867008650 CoA binding pocket [chemical binding]; other site 643867008651 elongation factor P; Validated; Region: PRK00529 643867008652 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 643867008653 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 643867008654 RNA binding site [nucleotide binding]; other site 643867008655 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 643867008656 RNA binding site [nucleotide binding]; other site 643867008657 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 643867008658 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 643867008659 carboxyltransferase (CT) interaction site; other site 643867008660 biotinylation site [posttranslational modification]; other site 643867008661 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 643867008662 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 643867008663 ATP-grasp domain; Region: ATP-grasp_4; cl17255 643867008664 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 643867008665 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 643867008666 homotrimer interaction site [polypeptide binding]; other site 643867008667 putative active site [active] 643867008668 exopolyphosphatase; Region: exo_poly_only; TIGR03706 643867008669 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 643867008670 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 643867008671 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 643867008672 putative active site [active] 643867008673 oxyanion strand; other site 643867008674 catalytic triad [active] 643867008675 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 643867008676 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 643867008677 catalytic residues [active] 643867008678 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 643867008679 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 643867008680 substrate binding site [chemical binding]; other site 643867008681 glutamase interaction surface [polypeptide binding]; other site 643867008682 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 643867008683 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 643867008684 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 643867008685 metal binding site [ion binding]; metal-binding site 643867008686 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 643867008687 putative FMN binding site [chemical binding]; other site 643867008688 putative dimer interface [polypeptide binding]; other site 643867008689 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 643867008690 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 643867008691 Ligand binding site; other site 643867008692 oligomer interface; other site 643867008693 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 643867008694 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 643867008695 dimer interface [polypeptide binding]; other site 643867008696 active site residues [active] 643867008697 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 643867008698 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 643867008699 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 643867008700 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 643867008701 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 643867008702 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 643867008703 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 643867008704 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 643867008705 generic binding surface II; other site 643867008706 generic binding surface I; other site 643867008707 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867008708 Ligand Binding Site [chemical binding]; other site 643867008709 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867008710 Ligand Binding Site [chemical binding]; other site 643867008711 Domain of unknown function (DUF202); Region: DUF202; pfam02656 643867008712 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867008713 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867008714 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867008715 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867008716 Tetratricopeptide repeat; Region: TPR_10; pfam13374 643867008717 CHAT domain; Region: CHAT; pfam12770 643867008718 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 643867008719 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 643867008720 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 643867008721 putative acyl-acceptor binding pocket; other site 643867008722 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 643867008723 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 643867008724 active site 643867008725 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 643867008726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 643867008727 ATP binding site [chemical binding]; other site 643867008728 putative Mg++ binding site [ion binding]; other site 643867008729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867008730 nucleotide binding region [chemical binding]; other site 643867008731 ATP-binding site [chemical binding]; other site 643867008732 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 643867008733 RNA binding site [nucleotide binding]; other site 643867008734 helicase 45; Provisional; Region: PTZ00424 643867008735 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 643867008736 ATP binding site [chemical binding]; other site 643867008737 Mg++ binding site [ion binding]; other site 643867008738 motif III; other site 643867008739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867008740 nucleotide binding region [chemical binding]; other site 643867008741 ATP-binding site [chemical binding]; other site 643867008742 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 643867008743 two component system sensor kinase SsrA; Provisional; Region: PRK15347 643867008744 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 643867008745 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 643867008746 putative NAD(P) binding site [chemical binding]; other site 643867008747 homotetramer interface [polypeptide binding]; other site 643867008748 homodimer interface [polypeptide binding]; other site 643867008749 active site 643867008750 PemK-like protein; Region: PemK; pfam02452 643867008751 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254 643867008752 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 643867008753 active site 643867008754 putative DNA-binding cleft [nucleotide binding]; other site 643867008755 dimer interface [polypeptide binding]; other site 643867008756 DNA polymerase I; Provisional; Region: PRK05755 643867008757 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 643867008758 active site 643867008759 metal binding site 1 [ion binding]; metal-binding site 643867008760 putative 5' ssDNA interaction site; other site 643867008761 metal binding site 3; metal-binding site 643867008762 metal binding site 2 [ion binding]; metal-binding site 643867008763 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 643867008764 putative DNA binding site [nucleotide binding]; other site 643867008765 putative metal binding site [ion binding]; other site 643867008766 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 643867008767 active site 643867008768 catalytic site [active] 643867008769 substrate binding site [chemical binding]; other site 643867008770 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 643867008771 active site 643867008772 DNA binding site [nucleotide binding] 643867008773 catalytic site [active] 643867008774 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 643867008775 universal stress protein UspE; Provisional; Region: PRK11175 643867008776 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867008777 Ligand Binding Site [chemical binding]; other site 643867008778 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 643867008779 Ligand Binding Site [chemical binding]; other site 643867008780 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 643867008781 UbiA prenyltransferase family; Region: UbiA; pfam01040 643867008782 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 643867008783 catalytic residues [active] 643867008784 dimer interface [polypeptide binding]; other site 643867008785 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 643867008786 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 643867008787 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 643867008788 active site 643867008789 HIGH motif; other site 643867008790 nucleotide binding site [chemical binding]; other site 643867008791 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 643867008792 KMSK motif region; other site 643867008793 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 643867008794 tRNA binding surface [nucleotide binding]; other site 643867008795 anticodon binding site; other site 643867008796 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 643867008797 Amidinotransferase; Region: Amidinotransf; pfam02274 643867008798 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 643867008799 Amidinotransferase; Region: Amidinotransf; cl12043 643867008800 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 643867008801 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 643867008802 dimer interface [polypeptide binding]; other site 643867008803 active site 643867008804 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 643867008805 catalytic residues [active] 643867008806 substrate binding site [chemical binding]; other site 643867008807 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 643867008808 GAF domain; Region: GAF; pfam01590 643867008809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867008810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867008811 dimer interface [polypeptide binding]; other site 643867008812 phosphorylation site [posttranslational modification] 643867008813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867008814 ATP binding site [chemical binding]; other site 643867008815 Mg2+ binding site [ion binding]; other site 643867008816 G-X-G motif; other site 643867008817 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 643867008818 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 643867008819 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 643867008820 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867008821 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 643867008822 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 643867008823 putative Iron-sulfur protein interface [polypeptide binding]; other site 643867008824 proximal heme binding site [chemical binding]; other site 643867008825 distal heme binding site [chemical binding]; other site 643867008826 putative dimer interface [polypeptide binding]; other site 643867008827 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 643867008828 L-aspartate oxidase; Provisional; Region: PRK06175 643867008829 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 643867008830 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 643867008831 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 643867008832 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 643867008833 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 643867008834 Na binding site [ion binding]; other site 643867008835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 643867008836 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 643867008837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 643867008838 Coenzyme A binding pocket [chemical binding]; other site 643867008839 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 643867008840 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 643867008841 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 643867008842 catalytic residue [active] 643867008843 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668 643867008844 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 643867008845 metal binding site [ion binding]; metal-binding site 643867008846 putative dimer interface [polypeptide binding]; other site 643867008847 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 643867008848 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 643867008849 active site 643867008850 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 643867008851 dimer interface [polypeptide binding]; other site 643867008852 substrate binding site [chemical binding]; other site 643867008853 catalytic residues [active] 643867008854 Haemolytic domain; Region: Haemolytic; pfam01809 643867008855 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 643867008856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867008857 TPR motif; other site 643867008858 binding surface 643867008859 TM2 domain; Region: TM2; pfam05154 643867008860 Haemolytic domain; Region: Haemolytic; pfam01809 643867008861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867008862 binding surface 643867008863 TPR motif; other site 643867008864 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 643867008865 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 643867008866 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 643867008867 nucleotide binding site [chemical binding]; other site 643867008868 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 643867008869 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 643867008870 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 643867008871 HSP70 interaction site [polypeptide binding]; other site 643867008872 KTSC domain; Region: KTSC; pfam13619 643867008873 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 643867008874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 643867008875 Coenzyme A binding pocket [chemical binding]; other site 643867008876 Uncharacterized conserved protein [Function unknown]; Region: COG1434 643867008877 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 643867008878 putative active site [active] 643867008879 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 643867008880 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 643867008881 S-formylglutathione hydrolase; Region: PLN02442 643867008882 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 643867008883 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 643867008884 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 643867008885 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 643867008886 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 643867008887 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 643867008888 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 643867008889 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 643867008890 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 643867008891 substrate binding site [chemical binding]; other site 643867008892 ATP binding site [chemical binding]; other site 643867008893 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 643867008894 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 643867008895 active site 643867008896 catalytic site [active] 643867008897 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 643867008898 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 643867008899 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 643867008900 CoA-transferase family III; Region: CoA_transf_3; pfam02515 643867008901 MraZ protein; Region: MraZ; pfam02381 643867008902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 643867008903 MraZ protein; Region: MraZ; pfam02381 643867008904 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 643867008905 MraW methylase family; Region: Methyltransf_5; cl17771 643867008906 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 643867008907 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 643867008908 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 643867008909 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 643867008910 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 643867008911 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 643867008912 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 643867008913 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 643867008914 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 643867008915 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 643867008916 Mg++ binding site [ion binding]; other site 643867008917 putative catalytic motif [active] 643867008918 putative substrate binding site [chemical binding]; other site 643867008919 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 643867008920 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 643867008921 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 643867008922 cell division protein FtsW; Region: ftsW; TIGR02614 643867008923 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 643867008924 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 643867008925 active site 643867008926 homodimer interface [polypeptide binding]; other site 643867008927 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 643867008928 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 643867008929 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 643867008930 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 643867008931 cell division protein FtsA; Region: ftsA; TIGR01174 643867008932 Cell division protein FtsA; Region: FtsA; smart00842 643867008933 Cell division protein FtsA; Region: FtsA; pfam14450 643867008934 cell division protein FtsZ; Validated; Region: PRK09330 643867008935 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 643867008936 nucleotide binding site [chemical binding]; other site 643867008937 SulA interaction site; other site 643867008938 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867008939 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867008940 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867008941 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049 643867008942 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867008943 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 643867008944 AAA domain; Region: AAA_28; pfam13521 643867008945 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 643867008946 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 643867008947 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867008948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867008949 binding surface 643867008950 TPR motif; other site 643867008951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867008952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867008953 binding surface 643867008954 TPR motif; other site 643867008955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867008956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867008957 dimer interface [polypeptide binding]; other site 643867008958 phosphorylation site [posttranslational modification] 643867008959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867008960 ATP binding site [chemical binding]; other site 643867008961 Mg2+ binding site [ion binding]; other site 643867008962 G-X-G motif; other site 643867008963 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 643867008964 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 643867008965 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 643867008966 metal ion-dependent adhesion site (MIDAS); other site 643867008967 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 643867008968 NADH(P)-binding; Region: NAD_binding_10; pfam13460 643867008969 putative NAD(P) binding site [chemical binding]; other site 643867008970 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 643867008971 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 643867008972 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 643867008973 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 643867008974 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 643867008975 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 643867008976 Beta-lactamase; Region: Beta-lactamase; pfam00144 643867008977 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 643867008978 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 643867008979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867008980 ATP binding site [chemical binding]; other site 643867008981 Mg2+ binding site [ion binding]; other site 643867008982 G-X-G motif; other site 643867008983 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 643867008984 ATP binding site [chemical binding]; other site 643867008985 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 643867008986 Rhomboid family; Region: Rhomboid; pfam01694 643867008987 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 643867008988 Rhomboid family; Region: Rhomboid; pfam01694 643867008989 Anti-sigma-K factor rskA; Region: RskA; pfam10099 643867008990 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 643867008991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867008992 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 643867008993 DNA binding residues [nucleotide binding] 643867008994 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 643867008995 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 643867008996 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 643867008997 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 643867008998 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 643867008999 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 643867009000 NAD(P) binding site [chemical binding]; other site 643867009001 homotetramer interface [polypeptide binding]; other site 643867009002 homodimer interface [polypeptide binding]; other site 643867009003 active site 643867009004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009005 binding surface 643867009006 Tetratricopeptide repeat; Region: TPR_16; pfam13432 643867009007 TPR motif; other site 643867009008 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867009009 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 643867009010 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867009011 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 643867009012 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 643867009013 ligand binding site [chemical binding]; other site 643867009014 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867009015 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 643867009016 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 643867009017 substrate binding site [chemical binding]; other site 643867009018 oxyanion hole (OAH) forming residues; other site 643867009019 trimer interface [polypeptide binding]; other site 643867009020 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 643867009021 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 643867009022 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 643867009023 trimer interface [polypeptide binding]; other site 643867009024 active site 643867009025 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 643867009026 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 643867009027 active site 643867009028 Substrate binding site; other site 643867009029 Mg++ binding site; other site 643867009030 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 643867009031 putative trimer interface [polypeptide binding]; other site 643867009032 putative CoA binding site [chemical binding]; other site 643867009033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009034 TPR motif; other site 643867009035 binding surface 643867009036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009037 binding surface 643867009038 TPR motif; other site 643867009039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009040 TPR motif; other site 643867009041 binding surface 643867009042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009043 TPR motif; other site 643867009044 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009045 binding surface 643867009046 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 643867009047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 643867009048 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 643867009049 Peptidase family M23; Region: Peptidase_M23; pfam01551 643867009050 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 643867009051 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 643867009052 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 643867009053 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 643867009054 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 643867009055 N-acetyl-D-glucosamine binding site [chemical binding]; other site 643867009056 catalytic residue [active] 643867009057 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 643867009058 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 643867009059 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 643867009060 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 643867009061 Malic enzyme, N-terminal domain; Region: malic; pfam00390 643867009062 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 643867009063 putative NAD(P) binding site [chemical binding]; other site 643867009064 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 643867009065 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 643867009066 RuvA N terminal domain; Region: RuvA_N; pfam01330 643867009067 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 643867009068 cell surface protein SprA; Region: surface_SprA; TIGR04189 643867009069 Motility related/secretion protein; Region: SprA_N; pfam14349 643867009070 Motility related/secretion protein; Region: SprA_N; pfam14349 643867009071 Motility related/secretion protein; Region: SprA_N; pfam14349 643867009072 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 643867009073 lipoyl attachment site [posttranslational modification]; other site 643867009074 Predicted integral membrane protein [Function unknown]; Region: COG5652 643867009075 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 643867009076 RmuC family; Region: RmuC; pfam02646 643867009077 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867009078 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867009079 GldH lipoprotein; Region: GldH_lipo; pfam14109 643867009080 PSP1 C-terminal conserved region; Region: PSP1; cl00770 643867009081 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 643867009082 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 643867009083 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 643867009084 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 643867009085 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 643867009086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 643867009087 ATP binding site [chemical binding]; other site 643867009088 putative Mg++ binding site [ion binding]; other site 643867009089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 643867009090 nucleotide binding region [chemical binding]; other site 643867009091 ATP-binding site [chemical binding]; other site 643867009092 RQC domain; Region: RQC; pfam09382 643867009093 HRDC domain; Region: HRDC; pfam00570 643867009094 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 643867009095 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 643867009096 Substrate binding site; other site 643867009097 VIT family; Region: VIT1; pfam01988 643867009098 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 643867009099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 643867009100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867009101 Walker A motif; other site 643867009102 ATP binding site [chemical binding]; other site 643867009103 Walker B motif; other site 643867009104 arginine finger; other site 643867009105 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 643867009106 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 643867009107 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 643867009108 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 643867009109 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 643867009110 FtsX-like permease family; Region: FtsX; pfam02687 643867009111 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 643867009112 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 643867009113 active site 643867009114 catalytic site [active] 643867009115 substrate binding site [chemical binding]; other site 643867009116 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 643867009117 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 643867009118 active site 643867009119 PHP Thumb interface [polypeptide binding]; other site 643867009120 metal binding site [ion binding]; metal-binding site 643867009121 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 643867009122 generic binding surface II; other site 643867009123 generic binding surface I; other site 643867009124 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 643867009125 putative dimer interface [polypeptide binding]; other site 643867009126 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 643867009127 Ligand binding site; other site 643867009128 Putative Catalytic site; other site 643867009129 DXD motif; other site 643867009130 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 643867009131 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 643867009132 DXD motif; other site 643867009133 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 643867009134 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 643867009135 active site residue [active] 643867009136 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 643867009137 elongation factor Ts; Provisional; Region: tsf; PRK09377 643867009138 UBA/TS-N domain; Region: UBA; pfam00627 643867009139 Elongation factor TS; Region: EF_TS; pfam00889 643867009140 Elongation factor TS; Region: EF_TS; pfam00889 643867009141 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 643867009142 rRNA interaction site [nucleotide binding]; other site 643867009143 S8 interaction site; other site 643867009144 putative laminin-1 binding site; other site 643867009145 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 643867009146 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 643867009147 23S rRNA interface [nucleotide binding]; other site 643867009148 L3 interface [polypeptide binding]; other site 643867009149 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 643867009150 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 643867009151 active site 643867009152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867009153 dimer interface [polypeptide binding]; other site 643867009154 phosphorylation site [posttranslational modification] 643867009155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867009156 ATP binding site [chemical binding]; other site 643867009157 Mg2+ binding site [ion binding]; other site 643867009158 G-X-G motif; other site 643867009159 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 643867009160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867009161 active site 643867009162 phosphorylation site [posttranslational modification] 643867009163 intermolecular recognition site; other site 643867009164 dimerization interface [polypeptide binding]; other site 643867009165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 643867009166 DNA binding site [nucleotide binding] 643867009167 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 643867009168 recombinase A; Provisional; Region: recA; PRK09354 643867009169 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 643867009170 hexamer interface [polypeptide binding]; other site 643867009171 Walker A motif; other site 643867009172 ATP binding site [chemical binding]; other site 643867009173 Walker B motif; other site 643867009174 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 643867009175 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 643867009176 Cytochrome c; Region: Cytochrom_C; pfam00034 643867009177 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 643867009178 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 643867009179 Cu(I) binding site [ion binding]; other site 643867009180 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 643867009181 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 643867009182 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 643867009183 ligand binding site [chemical binding]; other site 643867009184 flexible hinge region; other site 643867009185 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 643867009186 putative switch regulator; other site 643867009187 non-specific DNA interactions [nucleotide binding]; other site 643867009188 DNA binding site [nucleotide binding] 643867009189 sequence specific DNA binding site [nucleotide binding]; other site 643867009190 putative cAMP binding site [chemical binding]; other site 643867009191 CHASE2 domain; Region: CHASE2; pfam05226 643867009192 membrane ATPase/protein kinase; Provisional; Region: PRK09435 643867009193 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 643867009194 Walker A; other site 643867009195 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 643867009196 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867009197 FOG: PKD repeat [General function prediction only]; Region: COG3291 643867009198 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867009199 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 643867009200 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 643867009201 Ligand Binding Site [chemical binding]; other site 643867009202 Double zinc ribbon; Region: DZR; pfam12773 643867009203 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 643867009204 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 643867009205 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 643867009206 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 643867009207 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867009208 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867009209 Transcriptional regulator [Transcription]; Region: LysR; COG0583 643867009210 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 643867009211 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 643867009212 dimerization interface [polypeptide binding]; other site 643867009213 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 643867009214 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 643867009215 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 643867009216 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 643867009217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 643867009218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 643867009219 Major Facilitator Superfamily; Region: MFS_1; pfam07690 643867009220 putative substrate translocation pore; other site 643867009221 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 643867009222 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 643867009223 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 643867009224 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 643867009225 Ligand binding site [chemical binding]; other site 643867009226 Electron transfer flavoprotein domain; Region: ETF; pfam01012 643867009227 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 643867009228 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 643867009229 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 643867009230 Bifunctional nuclease; Region: DNase-RNase; pfam02577 643867009231 UvrB/uvrC motif; Region: UVR; pfam02151 643867009232 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 643867009233 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 643867009234 active site 643867009235 NTP binding site [chemical binding]; other site 643867009236 metal binding triad [ion binding]; metal-binding site 643867009237 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 643867009238 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 643867009239 Zn2+ binding site [ion binding]; other site 643867009240 Mg2+ binding site [ion binding]; other site 643867009241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867009242 binding surface 643867009243 TPR motif; other site 643867009244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 643867009245 substrate binding pocket [chemical binding]; other site 643867009246 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 643867009247 membrane-bound complex binding site; other site 643867009248 hinge residues; other site 643867009249 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 643867009250 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 643867009251 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 643867009252 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 643867009253 active site 643867009254 catalytic site [active] 643867009255 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 643867009256 FecR protein; Region: FecR; pfam04773 643867009257 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 643867009258 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 643867009259 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 643867009260 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 643867009261 putative ligand binding site [chemical binding]; other site 643867009262 sensory histidine kinase AtoS; Provisional; Region: PRK11360 643867009263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867009264 ATP binding site [chemical binding]; other site 643867009265 Mg2+ binding site [ion binding]; other site 643867009266 G-X-G motif; other site 643867009267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867009268 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 643867009269 active site 643867009270 phosphorylation site [posttranslational modification] 643867009271 intermolecular recognition site; other site 643867009272 dimerization interface [polypeptide binding]; other site 643867009273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867009274 Walker A motif; other site 643867009275 ATP binding site [chemical binding]; other site 643867009276 Walker B motif; other site 643867009277 arginine finger; other site 643867009278 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 643867009279 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 643867009280 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 643867009281 dimer interface [polypeptide binding]; other site 643867009282 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 643867009283 ligand binding site [chemical binding]; other site 643867009284 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 643867009285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867009286 salt bridge; other site 643867009287 non-specific DNA binding site [nucleotide binding]; other site 643867009288 sequence-specific DNA binding site [nucleotide binding]; other site 643867009289 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 643867009290 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867009291 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 643867009292 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 643867009293 Walker A/P-loop; other site 643867009294 ATP binding site [chemical binding]; other site 643867009295 Q-loop/lid; other site 643867009296 ABC transporter signature motif; other site 643867009297 Walker B; other site 643867009298 D-loop; other site 643867009299 H-loop/switch region; other site 643867009300 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867009301 FtsX-like permease family; Region: FtsX; pfam02687 643867009302 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867009303 FtsX-like permease family; Region: FtsX; pfam02687 643867009304 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 643867009305 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867009306 FtsX-like permease family; Region: FtsX; pfam02687 643867009307 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867009308 FtsX-like permease family; Region: FtsX; pfam02687 643867009309 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867009310 FtsX-like permease family; Region: FtsX; pfam02687 643867009311 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867009312 FtsX-like permease family; Region: FtsX; pfam02687 643867009313 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867009314 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 643867009315 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 643867009316 FtsX-like permease family; Region: FtsX; pfam02687 643867009317 FtsX-like permease family; Region: FtsX; pfam02687 643867009318 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867009319 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 643867009320 FtsX-like permease family; Region: FtsX; pfam02687 643867009321 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867009322 FtsX-like permease family; Region: FtsX; pfam02687 643867009323 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867009324 FtsX-like permease family; Region: FtsX; pfam02687 643867009325 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867009326 FtsX-like permease family; Region: FtsX; pfam02687 643867009327 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 643867009328 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 643867009329 Walker A/P-loop; other site 643867009330 ATP binding site [chemical binding]; other site 643867009331 Q-loop/lid; other site 643867009332 ABC transporter signature motif; other site 643867009333 Walker B; other site 643867009334 D-loop; other site 643867009335 H-loop/switch region; other site 643867009336 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 643867009337 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 643867009338 CAAX protease self-immunity; Region: Abi; pfam02517 643867009339 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 643867009340 MarR family; Region: MarR_2; pfam12802 643867009341 MarR family; Region: MarR_2; cl17246 643867009342 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 643867009343 active site 643867009344 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 643867009345 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 643867009346 Domain of unknown function DUF87; Region: DUF87; pfam01935 643867009347 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 643867009348 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 643867009349 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 643867009350 RibD C-terminal domain; Region: RibD_C; cl17279 643867009351 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 643867009352 HSP70 interaction site [polypeptide binding]; other site 643867009353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009354 TPR motif; other site 643867009355 Family description; Region: VCBS; pfam13517 643867009356 Family description; Region: VCBS; pfam13517 643867009357 Cadherin repeat-like domain; Region: CA_like; cl15786 643867009358 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867009359 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 643867009360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 643867009361 heat shock protein 90; Provisional; Region: PRK05218 643867009362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867009363 ATP binding site [chemical binding]; other site 643867009364 Mg2+ binding site [ion binding]; other site 643867009365 G-X-G motif; other site 643867009366 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 643867009367 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867009368 MORN repeat; Region: MORN; pfam02493 643867009369 MORN repeat; Region: MORN; pfam02493 643867009370 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 643867009371 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 643867009372 PAS fold; Region: PAS_4; pfam08448 643867009373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867009374 dimer interface [polypeptide binding]; other site 643867009375 phosphorylation site [posttranslational modification] 643867009376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867009377 ATP binding site [chemical binding]; other site 643867009378 Mg2+ binding site [ion binding]; other site 643867009379 G-X-G motif; other site 643867009380 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 643867009381 active site residue [active] 643867009382 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 643867009383 active site residue [active] 643867009384 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 643867009385 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 643867009386 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 643867009387 dimer interface [polypeptide binding]; other site 643867009388 active site 643867009389 heme binding site [chemical binding]; other site 643867009390 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 643867009391 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 643867009392 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 643867009393 putative acyl-acceptor binding pocket; other site 643867009394 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 643867009395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867009396 binding surface 643867009397 TPR motif; other site 643867009398 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 643867009399 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 643867009400 Walker A/P-loop; other site 643867009401 ATP binding site [chemical binding]; other site 643867009402 Q-loop/lid; other site 643867009403 ABC transporter signature motif; other site 643867009404 Walker B; other site 643867009405 D-loop; other site 643867009406 H-loop/switch region; other site 643867009407 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 643867009408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867009409 active site 643867009410 phosphorylation site [posttranslational modification] 643867009411 intermolecular recognition site; other site 643867009412 dimerization interface [polypeptide binding]; other site 643867009413 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 643867009414 DNA binding residues [nucleotide binding] 643867009415 dimerization interface [polypeptide binding]; other site 643867009416 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 643867009417 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 643867009418 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 643867009419 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 643867009420 putative active site [active] 643867009421 substrate binding site [chemical binding]; other site 643867009422 putative cosubstrate binding site; other site 643867009423 catalytic site [active] 643867009424 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 643867009425 substrate binding site [chemical binding]; other site 643867009426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867009427 HAMP domain; Region: HAMP; pfam00672 643867009428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867009429 dimer interface [polypeptide binding]; other site 643867009430 phosphorylation site [posttranslational modification] 643867009431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867009432 ATP binding site [chemical binding]; other site 643867009433 Mg2+ binding site [ion binding]; other site 643867009434 G-X-G motif; other site 643867009435 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 643867009436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867009437 Walker A/P-loop; other site 643867009438 ATP binding site [chemical binding]; other site 643867009439 Q-loop/lid; other site 643867009440 ABC transporter signature motif; other site 643867009441 Walker B; other site 643867009442 D-loop; other site 643867009443 H-loop/switch region; other site 643867009444 Permease; Region: Permease; pfam02405 643867009445 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 643867009446 classical (c) SDRs; Region: SDR_c; cd05233 643867009447 NAD(P) binding site [chemical binding]; other site 643867009448 active site 643867009449 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 643867009450 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 643867009451 inhibitor-cofactor binding pocket; inhibition site 643867009452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867009453 catalytic residue [active] 643867009454 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 643867009455 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 643867009456 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 643867009457 NAD(P) binding site [chemical binding]; other site 643867009458 homodimer interface [polypeptide binding]; other site 643867009459 substrate binding site [chemical binding]; other site 643867009460 active site 643867009461 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 643867009462 nudix motif; other site 643867009463 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 643867009464 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 643867009465 Walker A/P-loop; other site 643867009466 ATP binding site [chemical binding]; other site 643867009467 Q-loop/lid; other site 643867009468 ABC transporter signature motif; other site 643867009469 Walker B; other site 643867009470 D-loop; other site 643867009471 H-loop/switch region; other site 643867009472 ABC transporter; Region: ABC_tran_2; pfam12848 643867009473 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 643867009474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867009475 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 643867009476 non-specific DNA binding site [nucleotide binding]; other site 643867009477 salt bridge; other site 643867009478 sequence-specific DNA binding site [nucleotide binding]; other site 643867009479 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 643867009480 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 643867009481 TPR repeat; Region: TPR_11; pfam13414 643867009482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009483 binding surface 643867009484 TPR motif; other site 643867009485 TPR repeat; Region: TPR_11; pfam13414 643867009486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009487 binding surface 643867009488 TPR motif; other site 643867009489 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 643867009490 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 643867009491 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 643867009492 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 643867009493 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 643867009494 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 643867009495 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 643867009496 putative active site [active] 643867009497 putative metal binding site [ion binding]; other site 643867009498 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 643867009499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867009500 non-specific DNA binding site [nucleotide binding]; other site 643867009501 salt bridge; other site 643867009502 sequence-specific DNA binding site [nucleotide binding]; other site 643867009503 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 643867009504 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 643867009505 P-loop; other site 643867009506 Magnesium ion binding site [ion binding]; other site 643867009507 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 643867009508 Magnesium ion binding site [ion binding]; other site 643867009509 CHC2 zinc finger; Region: zf-CHC2; cl17510 643867009510 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 643867009511 active site 643867009512 metal binding site [ion binding]; metal-binding site 643867009513 interdomain interaction site; other site 643867009514 Phage associated DNA primase [General function prediction only]; Region: COG3378 643867009515 Helix-turn-helix domain; Region: HTH_17; pfam12728 643867009516 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 643867009517 active site 643867009518 DNA binding site [nucleotide binding] 643867009519 Int/Topo IB signature motif; other site 643867009520 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 643867009521 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 643867009522 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 643867009523 TrkA-C domain; Region: TrkA_C; pfam02080 643867009524 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 643867009525 Y-family of DNA polymerases; Region: PolY; cl12025 643867009526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867009527 non-specific DNA binding site [nucleotide binding]; other site 643867009528 Predicted transcriptional regulator [Transcription]; Region: COG2932 643867009529 salt bridge; other site 643867009530 sequence-specific DNA binding site [nucleotide binding]; other site 643867009531 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 643867009532 Catalytic site [active] 643867009533 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 643867009534 Protein export membrane protein; Region: SecD_SecF; cl14618 643867009535 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 643867009536 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 643867009537 HlyD family secretion protein; Region: HlyD_3; pfam13437 643867009538 GLPGLI family protein; Region: GLPGLI; TIGR01200 643867009539 GLPGLI family protein; Region: GLPGLI; TIGR01200 643867009540 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867009541 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 643867009542 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 643867009543 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 643867009544 Phosphoglycerate kinase; Region: PGK; pfam00162 643867009545 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 643867009546 substrate binding site [chemical binding]; other site 643867009547 hinge regions; other site 643867009548 ADP binding site [chemical binding]; other site 643867009549 catalytic site [active] 643867009550 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 643867009551 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 643867009552 TPR repeat; Region: TPR_11; pfam13414 643867009553 TPR repeat; Region: TPR_11; pfam13414 643867009554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009555 binding surface 643867009556 TPR motif; other site 643867009557 TPR repeat; Region: TPR_11; pfam13414 643867009558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009559 binding surface 643867009560 TPR motif; other site 643867009561 Uncharacterized conserved protein [Function unknown]; Region: COG3268 643867009562 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 643867009563 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 643867009564 nudix motif; other site 643867009565 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 643867009566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 643867009567 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 643867009568 Walker A/P-loop; other site 643867009569 ATP binding site [chemical binding]; other site 643867009570 Q-loop/lid; other site 643867009571 ABC transporter signature motif; other site 643867009572 Walker B; other site 643867009573 D-loop; other site 643867009574 H-loop/switch region; other site 643867009575 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 643867009576 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 643867009577 active site 643867009578 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 643867009579 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 643867009580 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 643867009581 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 643867009582 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 643867009583 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 643867009584 trimer interface [polypeptide binding]; other site 643867009585 active site 643867009586 UDP-GlcNAc binding site [chemical binding]; other site 643867009587 lipid binding site [chemical binding]; lipid-binding site 643867009588 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 643867009589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 643867009590 Zn2+ binding site [ion binding]; other site 643867009591 Mg2+ binding site [ion binding]; other site 643867009592 Response regulator receiver domain; Region: Response_reg; pfam00072 643867009593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867009594 active site 643867009595 phosphorylation site [posttranslational modification] 643867009596 intermolecular recognition site; other site 643867009597 dimerization interface [polypeptide binding]; other site 643867009598 PglZ domain; Region: PglZ; pfam08665 643867009599 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 643867009600 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 643867009601 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 643867009602 hexamer interface [polypeptide binding]; other site 643867009603 ligand binding site [chemical binding]; other site 643867009604 putative active site [active] 643867009605 NAD(P) binding site [chemical binding]; other site 643867009606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009607 binding surface 643867009608 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009609 TPR motif; other site 643867009610 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867009612 binding surface 643867009613 TPR motif; other site 643867009614 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 643867009615 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 643867009616 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 643867009617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 643867009618 motif II; other site 643867009619 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 643867009620 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 643867009621 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 643867009622 nucleotide binding site [chemical binding]; other site 643867009623 homotetrameric interface [polypeptide binding]; other site 643867009624 putative phosphate binding site [ion binding]; other site 643867009625 putative allosteric binding site; other site 643867009626 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 643867009627 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 643867009628 putative catalytic cysteine [active] 643867009629 Uncharacterized conserved protein [Function unknown]; Region: COG5276 643867009630 Uncharacterized conserved protein [Function unknown]; Region: COG5276 643867009631 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009633 binding surface 643867009634 TPR motif; other site 643867009635 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009636 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009637 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009638 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 643867009639 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867009640 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867009641 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867009642 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867009643 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867009644 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867009645 Bacterial Ig-like domain; Region: Big_5; pfam13205 643867009646 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867009647 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 643867009648 putative active site [active] 643867009649 Mn binding site [ion binding]; other site 643867009650 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 643867009651 catalytic core [active] 643867009652 DNA topoisomerase I; Provisional; Region: PRK08780 643867009653 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 643867009654 active site 643867009655 interdomain interaction site; other site 643867009656 putative metal-binding site [ion binding]; other site 643867009657 nucleotide binding site [chemical binding]; other site 643867009658 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 643867009659 domain I; other site 643867009660 DNA binding groove [nucleotide binding] 643867009661 phosphate binding site [ion binding]; other site 643867009662 domain II; other site 643867009663 domain III; other site 643867009664 nucleotide binding site [chemical binding]; other site 643867009665 catalytic site [active] 643867009666 domain IV; other site 643867009667 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 643867009668 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 643867009669 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 643867009670 Predicted acetyltransferase [General function prediction only]; Region: COG2388 643867009671 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 643867009672 EamA-like transporter family; Region: EamA; pfam00892 643867009673 EamA-like transporter family; Region: EamA; pfam00892 643867009674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867009675 PAS fold; Region: PAS_3; pfam08447 643867009676 putative active site [active] 643867009677 heme pocket [chemical binding]; other site 643867009678 PAS domain; Region: PAS_9; pfam13426 643867009679 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867009680 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867009681 dimer interface [polypeptide binding]; other site 643867009682 phosphorylation site [posttranslational modification] 643867009683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867009684 ATP binding site [chemical binding]; other site 643867009685 G-X-G motif; other site 643867009686 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 643867009687 oligomerization interface [polypeptide binding]; other site 643867009688 active site 643867009689 metal binding site [ion binding]; metal-binding site 643867009690 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 643867009691 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 643867009692 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 643867009693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 643867009694 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867009695 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867009696 Mechanosensitive ion channel; Region: MS_channel; pfam00924 643867009697 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 643867009698 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 643867009699 NADP binding site [chemical binding]; other site 643867009700 homopentamer interface [polypeptide binding]; other site 643867009701 substrate binding site [chemical binding]; other site 643867009702 active site 643867009703 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 643867009704 active site 643867009705 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970 643867009706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 643867009707 Walker A motif; other site 643867009708 ATP binding site [chemical binding]; other site 643867009709 Walker B motif; other site 643867009710 arginine finger; other site 643867009711 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 643867009712 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 643867009713 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 643867009714 Protein of unknown function, DUF481; Region: DUF481; cl01213 643867009715 Response regulator receiver domain; Region: Response_reg; pfam00072 643867009716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867009717 active site 643867009718 phosphorylation site [posttranslational modification] 643867009719 intermolecular recognition site; other site 643867009720 dimerization interface [polypeptide binding]; other site 643867009721 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 643867009722 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 643867009723 N-acetyl-D-glucosamine binding site [chemical binding]; other site 643867009724 catalytic residue [active] 643867009725 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 643867009726 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 643867009727 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 643867009728 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 643867009729 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 643867009730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867009731 S-adenosylmethionine binding site [chemical binding]; other site 643867009732 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 643867009733 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 643867009734 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 643867009735 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867009736 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 643867009737 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 643867009738 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867009739 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 643867009740 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 643867009741 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 643867009742 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 643867009743 trimer interface [polypeptide binding]; other site 643867009744 active site 643867009745 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 643867009746 catalytic site [active] 643867009747 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 643867009748 Glycogen synthase; Region: Glycogen_syn; pfam05693 643867009749 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 643867009750 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 643867009751 Putative zinc ribbon domain; Region: DUF164; pfam02591 643867009752 Uncharacterized conserved protein [Function unknown]; Region: COG0327 643867009753 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 643867009754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 643867009755 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 643867009756 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 643867009757 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 643867009758 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 643867009759 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 643867009760 active site 643867009761 dinuclear metal binding site [ion binding]; other site 643867009762 dimerization interface [polypeptide binding]; other site 643867009763 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 643867009764 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 643867009765 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 643867009766 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 643867009767 Protein of unknown function DUF86; Region: DUF86; cl01031 643867009768 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 643867009769 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 643867009770 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 643867009771 putative trimer interface [polypeptide binding]; other site 643867009772 putative CoA binding site [chemical binding]; other site 643867009773 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 643867009774 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 643867009775 active site residue [active] 643867009776 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 643867009777 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 643867009778 Two component regulator propeller; Region: Reg_prop; pfam07494 643867009779 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 643867009780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867009781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867009782 ATP binding site [chemical binding]; other site 643867009783 Mg2+ binding site [ion binding]; other site 643867009784 G-X-G motif; other site 643867009785 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 643867009786 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 643867009787 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 643867009788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 643867009789 Protein of unknown function, DUF547; Region: DUF547; pfam04784 643867009790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 643867009791 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 643867009792 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 643867009793 4Fe-4S binding domain; Region: Fer4_5; pfam12801 643867009794 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 643867009795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 643867009796 Coenzyme A binding pocket [chemical binding]; other site 643867009797 PemK-like protein; Region: PemK; pfam02452 643867009798 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 643867009799 putative active site [active] 643867009800 putative metal binding site [ion binding]; other site 643867009801 imidazolonepropionase; Validated; Region: PRK09356 643867009802 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 643867009803 active site 643867009804 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 643867009805 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 643867009806 putative dimer interface [polypeptide binding]; other site 643867009807 putative anticodon binding site; other site 643867009808 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 643867009809 homodimer interface [polypeptide binding]; other site 643867009810 motif 1; other site 643867009811 motif 2; other site 643867009812 active site 643867009813 motif 3; other site 643867009814 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 643867009815 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 643867009816 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 643867009817 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 643867009818 enoyl-CoA hydratase; Provisional; Region: PRK08140 643867009819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 643867009820 substrate binding site [chemical binding]; other site 643867009821 oxyanion hole (OAH) forming residues; other site 643867009822 trimer interface [polypeptide binding]; other site 643867009823 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 643867009824 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 643867009825 active site 643867009826 catalytic residues [active] 643867009827 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 643867009828 proline aminopeptidase P II; Provisional; Region: PRK10879 643867009829 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 643867009830 active site 643867009831 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 643867009832 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 643867009833 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 643867009834 DinB superfamily; Region: DinB_2; pfam12867 643867009835 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 643867009836 homotrimer interaction site [polypeptide binding]; other site 643867009837 putative active site [active] 643867009838 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 643867009839 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867009840 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 643867009841 NHL repeat; Region: NHL; pfam01436 643867009842 conserved repeat domain; Region: B_ant_repeat; TIGR01451 643867009843 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867009844 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 643867009845 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 643867009846 hexamer interface [polypeptide binding]; other site 643867009847 ligand binding site [chemical binding]; other site 643867009848 putative active site [active] 643867009849 NAD(P) binding site [chemical binding]; other site 643867009850 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 643867009851 tetramer interface [polypeptide binding]; other site 643867009852 TPP-binding site [chemical binding]; other site 643867009853 heterodimer interface [polypeptide binding]; other site 643867009854 phosphorylation loop region [posttranslational modification] 643867009855 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 643867009856 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 643867009857 PYR/PP interface [polypeptide binding]; other site 643867009858 dimer interface [polypeptide binding]; other site 643867009859 TPP binding site [chemical binding]; other site 643867009860 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 643867009861 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 643867009862 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 643867009863 active site 643867009864 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 643867009865 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 643867009866 active site 643867009867 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867009868 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 643867009869 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867009870 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 643867009871 FAD binding site [chemical binding]; other site 643867009872 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 643867009873 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 643867009874 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 643867009875 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 643867009876 substrate binding pocket [chemical binding]; other site 643867009877 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 643867009878 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 643867009879 putative active site [active] 643867009880 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 643867009881 B12 binding site [chemical binding]; other site 643867009882 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 643867009883 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867009885 binding surface 643867009886 TPR motif; other site 643867009887 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009888 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 643867009889 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 643867009890 DNA binding residues [nucleotide binding] 643867009891 dimerization interface [polypeptide binding]; other site 643867009892 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867009893 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867009894 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 643867009895 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 643867009896 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 643867009897 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 643867009898 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 643867009899 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867009900 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 643867009901 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867009902 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 643867009903 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 643867009904 S-formylglutathione hydrolase; Region: PLN02442 643867009905 nucleophilic elbow; other site 643867009906 catalytic triad; other site 643867009907 Pyruvate formate lyase; Region: PFL; pfam02901 643867009908 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 643867009909 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 643867009910 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 643867009911 acyl-activating enzyme (AAE) consensus motif; other site 643867009912 acyl-activating enzyme (AAE) consensus motif; other site 643867009913 putative AMP binding site [chemical binding]; other site 643867009914 putative active site [active] 643867009915 putative CoA binding site [chemical binding]; other site 643867009916 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 643867009917 Na binding site [ion binding]; other site 643867009918 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 643867009919 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 643867009920 dimer interface [polypeptide binding]; other site 643867009921 active site 643867009922 CoA binding pocket [chemical binding]; other site 643867009923 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 643867009924 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 643867009925 NAD(P) binding site [chemical binding]; other site 643867009926 homotetramer interface [polypeptide binding]; other site 643867009927 homodimer interface [polypeptide binding]; other site 643867009928 active site 643867009929 Protein of unknown function, DUF547; Region: DUF547; pfam04784 643867009930 Surface antigen; Region: Bac_surface_Ag; pfam01103 643867009931 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009933 TPR motif; other site 643867009934 binding surface 643867009935 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867009937 TPR motif; other site 643867009938 binding surface 643867009939 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867009940 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 643867009941 GMP synthase; Reviewed; Region: guaA; PRK00074 643867009942 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 643867009943 AMP/PPi binding site [chemical binding]; other site 643867009944 candidate oxyanion hole; other site 643867009945 catalytic triad [active] 643867009946 potential glutamine specificity residues [chemical binding]; other site 643867009947 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 643867009948 ATP Binding subdomain [chemical binding]; other site 643867009949 Ligand Binding sites [chemical binding]; other site 643867009950 Dimerization subdomain; other site 643867009951 Tetratricopeptide repeat; Region: TPR_16; pfam13432 643867009952 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 643867009953 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 643867009954 ligand binding site [chemical binding]; other site 643867009955 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 643867009956 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 643867009957 inhibitor-cofactor binding pocket; inhibition site 643867009958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867009959 catalytic residue [active] 643867009960 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 643867009961 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 643867009962 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 643867009963 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 643867009964 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 643867009965 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 643867009966 Predicted transporter component [General function prediction only]; Region: COG2391 643867009967 Sulphur transport; Region: Sulf_transp; pfam04143 643867009968 Cytochrome c [Energy production and conversion]; Region: COG3258 643867009969 Cytochrome c; Region: Cytochrom_C; pfam00034 643867009970 outer membrane porin, OprD family; Region: OprD; pfam03573 643867009971 isocitrate lyase; Provisional; Region: PRK15063 643867009972 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 643867009973 tetramer interface [polypeptide binding]; other site 643867009974 active site 643867009975 Mg2+/Mn2+ binding site [ion binding]; other site 643867009976 malate synthase A; Region: malate_syn_A; TIGR01344 643867009977 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 643867009978 active site 643867009979 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 643867009980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867009981 non-specific DNA binding site [nucleotide binding]; other site 643867009982 salt bridge; other site 643867009983 sequence-specific DNA binding site [nucleotide binding]; other site 643867009984 Domain of unknown function (DUF955); Region: DUF955; pfam06114 643867009985 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 643867009986 Cytochrome c; Region: Cytochrom_C; pfam00034 643867009987 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 643867009988 Cytochrome c; Region: Cytochrom_C; pfam00034 643867009989 Predicted transcriptional regulator [Transcription]; Region: COG1959 643867009990 Transcriptional regulator; Region: Rrf2; pfam02082 643867009991 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 643867009992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867009993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 643867009994 dimer interface [polypeptide binding]; other site 643867009995 phosphorylation site [posttranslational modification] 643867009996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867009997 ATP binding site [chemical binding]; other site 643867009998 G-X-G motif; other site 643867009999 Uncharacterized conserved protein [Function unknown]; Region: COG4278 643867010000 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 643867010001 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 643867010002 FtsX-like permease family; Region: FtsX; pfam02687 643867010003 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 643867010004 active site 643867010005 catalytic residues [active] 643867010006 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867010007 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867010008 Histidine kinase; Region: His_kinase; pfam06580 643867010009 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 643867010010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 643867010011 active site 643867010012 phosphorylation site [posttranslational modification] 643867010013 intermolecular recognition site; other site 643867010014 dimerization interface [polypeptide binding]; other site 643867010015 LytTr DNA-binding domain; Region: LytTR; smart00850 643867010016 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 643867010017 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 643867010018 G1 box; other site 643867010019 putative GEF interaction site [polypeptide binding]; other site 643867010020 GTP/Mg2+ binding site [chemical binding]; other site 643867010021 Switch I region; other site 643867010022 G2 box; other site 643867010023 G3 box; other site 643867010024 Switch II region; other site 643867010025 G4 box; other site 643867010026 G5 box; other site 643867010027 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 643867010028 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 643867010029 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 643867010030 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 643867010031 Uncharacterized conserved protein [Function unknown]; Region: COG3586 643867010032 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 643867010033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867010034 non-specific DNA binding site [nucleotide binding]; other site 643867010035 salt bridge; other site 643867010036 sequence-specific DNA binding site [nucleotide binding]; other site 643867010037 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 643867010038 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 643867010039 cofactor binding site; other site 643867010040 DNA binding site [nucleotide binding] 643867010041 substrate interaction site [chemical binding]; other site 643867010042 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 643867010043 Restriction endonuclease BpuJI - N terminal; Region: BpuJI_N; pfam11564 643867010044 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 643867010045 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 643867010046 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 643867010047 cofactor binding site; other site 643867010048 DNA binding site [nucleotide binding] 643867010049 substrate interaction site [chemical binding]; other site 643867010050 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 643867010051 active site 643867010052 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 643867010053 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 643867010054 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 643867010055 active site 643867010056 catalytic tetrad [active] 643867010057 cytochrome c-550; Provisional; Region: psbV; cl17239 643867010058 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 643867010059 Cytochrome c; Region: Cytochrom_C; pfam00034 643867010060 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 643867010061 heme-binding residues [chemical binding]; other site 643867010062 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 643867010063 molybdopterin cofactor binding site; other site 643867010064 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 643867010065 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 643867010066 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 643867010067 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 643867010068 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 643867010069 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 643867010070 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 643867010071 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 643867010072 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 643867010073 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 643867010074 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 643867010075 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 643867010076 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 643867010077 UbiA prenyltransferase family; Region: UbiA; pfam01040 643867010078 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 643867010079 Subunit I/III interface [polypeptide binding]; other site 643867010080 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 643867010081 Subunit I/III interface [polypeptide binding]; other site 643867010082 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 643867010083 Protein of unknown function (DUF420); Region: DUF420; pfam04238 643867010084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867010085 TPR motif; other site 643867010086 binding surface 643867010087 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867010088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 643867010089 Histidine kinase; Region: HisKA_3; pfam07730 643867010090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867010091 ATP binding site [chemical binding]; other site 643867010092 Mg2+ binding site [ion binding]; other site 643867010093 G-X-G motif; other site 643867010094 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 643867010095 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 643867010096 substrate-cofactor binding pocket; other site 643867010097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867010098 catalytic residue [active] 643867010099 PAS domain; Region: PAS_9; pfam13426 643867010100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 643867010101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 643867010102 ATP binding site [chemical binding]; other site 643867010103 Mg2+ binding site [ion binding]; other site 643867010104 G-X-G motif; other site 643867010105 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 643867010106 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 643867010107 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 643867010108 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 643867010109 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 643867010110 hypothetical protein; Provisional; Region: PRK13665 643867010111 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 643867010112 prolyl-tRNA synthetase; Provisional; Region: PRK08661 643867010113 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 643867010114 dimer interface [polypeptide binding]; other site 643867010115 motif 1; other site 643867010116 active site 643867010117 motif 2; other site 643867010118 motif 3; other site 643867010119 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 643867010120 anticodon binding site; other site 643867010121 zinc-binding site [ion binding]; other site 643867010122 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 643867010123 ADP binding site [chemical binding]; other site 643867010124 magnesium binding site [ion binding]; other site 643867010125 putative shikimate binding site; other site 643867010126 DoxX; Region: DoxX; pfam07681 643867010127 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 643867010128 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 643867010129 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 643867010130 dihydropteroate synthase; Region: DHPS; TIGR01496 643867010131 substrate binding pocket [chemical binding]; other site 643867010132 dimer interface [polypeptide binding]; other site 643867010133 inhibitor binding site; inhibition site 643867010134 Uncharacterized conserved protein [Function unknown]; Region: COG1624 643867010135 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 643867010136 enoyl-CoA hydratase; Provisional; Region: PRK05862 643867010137 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 643867010138 substrate binding site [chemical binding]; other site 643867010139 oxyanion hole (OAH) forming residues; other site 643867010140 trimer interface [polypeptide binding]; other site 643867010141 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 643867010142 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 643867010143 catalytic residue [active] 643867010144 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 643867010145 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 643867010146 RNA/DNA hybrid binding site [nucleotide binding]; other site 643867010147 active site 643867010148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 643867010149 binding surface 643867010150 Tetratricopeptide repeat; Region: TPR_16; pfam13432 643867010151 TPR motif; other site 643867010152 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 643867010153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 643867010154 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 643867010155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 643867010156 binding surface 643867010157 TPR motif; other site 643867010158 Tetratricopeptide repeat; Region: TPR_12; pfam13424 643867010159 CHAT domain; Region: CHAT; pfam12770 643867010160 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 643867010161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 643867010162 S-adenosylmethionine binding site [chemical binding]; other site 643867010163 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 643867010164 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 643867010165 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 643867010166 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 643867010167 CheB methylesterase; Region: CheB_methylest; pfam01339 643867010168 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 643867010169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 643867010170 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 643867010171 GAF domain; Region: GAF_3; pfam13492 643867010172 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 643867010173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867010174 putative active site [active] 643867010175 heme pocket [chemical binding]; other site 643867010176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 643867010177 putative active site [active] 643867010178 heme pocket [chemical binding]; other site 643867010179 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 643867010180 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 643867010181 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 643867010182 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 643867010183 Walker A/P-loop; other site 643867010184 ATP binding site [chemical binding]; other site 643867010185 Q-loop/lid; other site 643867010186 ABC transporter signature motif; other site 643867010187 Walker B; other site 643867010188 D-loop; other site 643867010189 H-loop/switch region; other site 643867010190 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 643867010191 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 643867010192 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 643867010193 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 643867010194 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 643867010195 Ligand binding site; other site 643867010196 Putative Catalytic site; other site 643867010197 DXD motif; other site 643867010198 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 643867010199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 643867010200 active site 643867010201 motif I; other site 643867010202 motif II; other site 643867010203 adenylosuccinate lyase; Provisional; Region: PRK09285 643867010204 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 643867010205 tetramer interface [polypeptide binding]; other site 643867010206 active site 643867010207 integral membrane protein; Region: integ_memb_HG; TIGR03954 643867010208 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 643867010209 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 643867010210 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 643867010211 NAD binding site [chemical binding]; other site 643867010212 ligand binding site [chemical binding]; other site 643867010213 catalytic site [active] 643867010214 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 643867010215 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 643867010216 RNA binding surface [nucleotide binding]; other site 643867010217 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 643867010218 active site 643867010219 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 643867010220 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 643867010221 Catalytic site [active] 643867010222 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 643867010223 dihydrodipicolinate reductase; Provisional; Region: PRK00048 643867010224 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 643867010225 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 643867010226 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 643867010227 ParB-like nuclease domain; Region: ParBc; pfam02195 643867010228 KorB domain; Region: KorB; pfam08535 643867010229 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 643867010230 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 643867010231 P-loop; other site 643867010232 Magnesium ion binding site [ion binding]; other site 643867010233 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 643867010234 Magnesium ion binding site [ion binding]; other site 643867010235 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 643867010236 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 643867010237 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 643867010238 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 643867010239 putative acyl-acceptor binding pocket; other site 643867010240 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 643867010241 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 643867010242 homodimer interface [polypeptide binding]; other site 643867010243 substrate-cofactor binding pocket; other site 643867010244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 643867010245 catalytic residue [active] 643867010246 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 643867010247 Mechanosensitive ion channel; Region: MS_channel; pfam00924 643867010248 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 643867010249 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 643867010250 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 643867010251 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 643867010252 hydroxyglutarate oxidase; Provisional; Region: PRK11728 643867010253 glycerol kinase; Provisional; Region: glpK; PRK00047 643867010254 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 643867010255 N- and C-terminal domain interface [polypeptide binding]; other site 643867010256 active site 643867010257 MgATP binding site [chemical binding]; other site 643867010258 catalytic site [active] 643867010259 metal binding site [ion binding]; metal-binding site 643867010260 glycerol binding site [chemical binding]; other site 643867010261 homotetramer interface [polypeptide binding]; other site 643867010262 homodimer interface [polypeptide binding]; other site 643867010263 FBP binding site [chemical binding]; other site 643867010264 protein IIAGlc interface [polypeptide binding]; other site 643867010265 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 643867010266 amphipathic channel; other site 643867010267 Asn-Pro-Ala signature motifs; other site 643867010268 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 643867010269 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 643867010270 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 643867010271 Ferritin-like domain; Region: Ferritin; pfam00210 643867010272 ferroxidase diiron center [ion binding]; other site 643867010273 aconitate hydratase; Validated; Region: PRK07229 643867010274 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 643867010275 substrate binding site [chemical binding]; other site 643867010276 ligand binding site [chemical binding]; other site 643867010277 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 643867010278 substrate binding site [chemical binding]; other site 643867010279 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 643867010280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 643867010281 non-specific DNA binding site [nucleotide binding]; other site 643867010282 salt bridge; other site 643867010283 sequence-specific DNA binding site [nucleotide binding]; other site 643867010284 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 643867010285 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 643867010286 Transcriptional regulators [Transcription]; Region: MarR; COG1846 643867010287 inner membrane protein; Provisional; Region: PRK11715 643867010288 DoxX-like family; Region: DoxX_2; pfam13564 643867010289 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 643867010290 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 643867010291 substrate binding site [chemical binding]; other site 643867010292 oxyanion hole (OAH) forming residues; other site 643867010293 trimer interface [polypeptide binding]; other site 643867010294 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 643867010295 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 643867010296 dimer interface [polypeptide binding]; other site 643867010297 tetramer interface [polypeptide binding]; other site 643867010298 PYR/PP interface [polypeptide binding]; other site 643867010299 TPP binding site [chemical binding]; other site 643867010300 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 643867010301 TPP-binding site; other site 643867010302 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 643867010303 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 643867010304 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 643867010305 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 643867010306 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 643867010307 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 643867010308 Cna protein B-type domain; Region: Cna_B_2; pfam13715 643867010309 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 643867010310 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 643867010311 Ycf48-like protein; Provisional; Region: PRK13684 643867010312 VPS10 domain; Region: VPS10; smart00602 643867010313 VPS10 domain; Region: VPS10; smart00602 643867010314 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 643867010315 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 643867010316 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 643867010317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 643867010318 NAD(P) binding site [chemical binding]; other site 643867010319 active site 643867010320 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 643867010321 ligand binding site; other site 643867010322 tetramer interface; other site 643867010323 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 643867010324 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 643867010325 NeuB family; Region: NeuB; pfam03102 643867010326 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 643867010327 NeuB binding interface [polypeptide binding]; other site 643867010328 putative substrate binding site [chemical binding]; other site 643867010329 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 643867010330 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 643867010331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 643867010332 active site 643867010333 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 643867010334 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 643867010335 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 643867010336 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 643867010337 active site 643867010338 substrate binding site [chemical binding]; other site 643867010339 coenzyme B12 binding site [chemical binding]; other site 643867010340 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 643867010341 B12 binding site [chemical binding]; other site 643867010342 cobalt ligand [ion binding]; other site 643867010343 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 643867010344 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817