-- dump date   	20140619_140318
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1064535000001	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1064535000002	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1064535000003	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1064535000004	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1064535000005	inhibitor-cofactor binding pocket; inhibition site
1064535000006	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535000007	catalytic residue [active]
1064535000008	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1064535000009	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1064535000010	metal binding site [ion binding]; metal-binding site
1064535000011	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1064535000012	dimer interface [polypeptide binding]; other site
1064535000013	catalytic triad [active]
1064535000014	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1064535000015	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1064535000016	peptide binding site [polypeptide binding]; other site
1064535000017	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1064535000018	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1064535000019	Walker A/P-loop; other site
1064535000020	ATP binding site [chemical binding]; other site
1064535000021	Q-loop/lid; other site
1064535000022	ABC transporter signature motif; other site
1064535000023	Walker B; other site
1064535000024	D-loop; other site
1064535000025	H-loop/switch region; other site
1064535000026	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1064535000027	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1064535000028	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1064535000029	Walker A/P-loop; other site
1064535000030	ATP binding site [chemical binding]; other site
1064535000031	Q-loop/lid; other site
1064535000032	ABC transporter signature motif; other site
1064535000033	Walker B; other site
1064535000034	D-loop; other site
1064535000035	H-loop/switch region; other site
1064535000036	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1064535000037	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1064535000038	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1064535000039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535000040	dimer interface [polypeptide binding]; other site
1064535000041	conserved gate region; other site
1064535000042	putative PBP binding loops; other site
1064535000043	ABC-ATPase subunit interface; other site
1064535000044	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1064535000045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535000046	dimer interface [polypeptide binding]; other site
1064535000047	conserved gate region; other site
1064535000048	putative PBP binding loops; other site
1064535000049	ABC-ATPase subunit interface; other site
1064535000050	drug efflux system protein MdtG; Provisional; Region: PRK09874
1064535000051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535000052	putative substrate translocation pore; other site
1064535000053	L-aspartate oxidase; Provisional; Region: PRK06175
1064535000054	FAD binding domain; Region: FAD_binding_2; pfam00890
1064535000055	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1064535000056	catalytic loop [active]
1064535000057	iron binding site [ion binding]; other site
1064535000058	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1064535000059	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1064535000060	pyruvate carboxylase; Reviewed; Region: PRK12999
1064535000061	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1064535000062	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1064535000063	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1064535000064	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1064535000065	active site
1064535000066	catalytic residues [active]
1064535000067	metal binding site [ion binding]; metal-binding site
1064535000068	homodimer binding site [polypeptide binding]; other site
1064535000069	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1064535000070	carboxyltransferase (CT) interaction site; other site
1064535000071	biotinylation site [posttranslational modification]; other site
1064535000072	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1064535000073	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
1064535000074	putative FMN binding site [chemical binding]; other site
1064535000075	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1064535000076	amino acid carrier protein; Region: agcS; TIGR00835
1064535000077	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1064535000078	active site
1064535000079	catalytic motif [active]
1064535000080	Zn binding site [ion binding]; other site
1064535000081	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1064535000082	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1064535000083	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
1064535000084	DXD motif; other site
1064535000085	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1064535000086	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1064535000087	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1064535000088	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1064535000089	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1064535000090	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1064535000091	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1064535000092	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1064535000093	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1064535000094	active site
1064535000095	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1064535000096	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1064535000097	ssDNA binding site; other site
1064535000098	generic binding surface II; other site
1064535000099	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1064535000100	ATP binding site [chemical binding]; other site
1064535000101	putative Mg++ binding site [ion binding]; other site
1064535000102	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1064535000103	nucleotide binding region [chemical binding]; other site
1064535000104	ATP-binding site [chemical binding]; other site
1064535000105	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1064535000106	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1064535000107	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1064535000108	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1064535000109	NAD(P) binding site [chemical binding]; other site
1064535000110	LDH/MDH dimer interface [polypeptide binding]; other site
1064535000111	substrate binding site [chemical binding]; other site
1064535000112	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1064535000113	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1064535000114	active site
1064535000115	nucleotide binding site [chemical binding]; other site
1064535000116	HIGH motif; other site
1064535000117	KMSKS motif; other site
1064535000118	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1064535000119	HTH domain; Region: HTH_11; pfam08279
1064535000120	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1064535000121	FOG: CBS domain [General function prediction only]; Region: COG0517
1064535000122	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1064535000123	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1064535000124	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1064535000125	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1064535000126	Transglycosylase; Region: Transgly; pfam00912
1064535000127	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1064535000128	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1064535000129	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1064535000130	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1064535000131	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1064535000132	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1064535000133	substrate binding site [chemical binding]; other site
1064535000134	oxyanion hole (OAH) forming residues; other site
1064535000135	trimer interface [polypeptide binding]; other site
1064535000136	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1064535000137	Na binding site [ion binding]; other site
1064535000138	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1064535000139	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1064535000140	HlyD family secretion protein; Region: HlyD_3; pfam13437
1064535000141	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1064535000142	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1064535000143	Walker A/P-loop; other site
1064535000144	ATP binding site [chemical binding]; other site
1064535000145	Q-loop/lid; other site
1064535000146	ABC transporter signature motif; other site
1064535000147	Walker B; other site
1064535000148	D-loop; other site
1064535000149	H-loop/switch region; other site
1064535000150	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1064535000151	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1064535000152	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535000153	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
1064535000154	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535000155	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535000156	homodimer interface [polypeptide binding]; other site
1064535000157	catalytic residue [active]
1064535000158	GTP-binding protein YchF; Reviewed; Region: PRK09601
1064535000159	YchF GTPase; Region: YchF; cd01900
1064535000160	G1 box; other site
1064535000161	GTP/Mg2+ binding site [chemical binding]; other site
1064535000162	Switch I region; other site
1064535000163	G2 box; other site
1064535000164	Switch II region; other site
1064535000165	G3 box; other site
1064535000166	G4 box; other site
1064535000167	G5 box; other site
1064535000168	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1064535000169	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1064535000170	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1064535000171	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1064535000172	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1064535000173	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535000174	non-specific DNA binding site [nucleotide binding]; other site
1064535000175	salt bridge; other site
1064535000176	sequence-specific DNA binding site [nucleotide binding]; other site
1064535000177	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1064535000178	FAD binding domain; Region: FAD_binding_4; pfam01565
1064535000179	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1064535000180	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1064535000181	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1064535000182	ABC transporter; Region: ABC_tran_2; pfam12848
1064535000183	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1064535000184	Transposase; Region: HTH_Tnp_1; cl17663
1064535000185	putative transposase OrfB; Reviewed; Region: PHA02517
1064535000186	HTH-like domain; Region: HTH_21; pfam13276
1064535000187	Integrase core domain; Region: rve; pfam00665
1064535000188	Integrase core domain; Region: rve_3; pfam13683
1064535000189	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1064535000190	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1064535000191	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1064535000192	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1064535000193	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1064535000194	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1064535000195	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
1064535000196	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1064535000197	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1064535000198	ATP binding site [chemical binding]; other site
1064535000199	putative Mg++ binding site [ion binding]; other site
1064535000200	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1064535000201	nucleotide binding region [chemical binding]; other site
1064535000202	ATP-binding site [chemical binding]; other site
1064535000203	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1064535000204	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1064535000205	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1064535000206	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1064535000207	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1064535000208	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1064535000209	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535000210	dimer interface [polypeptide binding]; other site
1064535000211	conserved gate region; other site
1064535000212	putative PBP binding loops; other site
1064535000213	ABC-ATPase subunit interface; other site
1064535000214	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1064535000215	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1064535000216	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1064535000217	Walker A/P-loop; other site
1064535000218	ATP binding site [chemical binding]; other site
1064535000219	Q-loop/lid; other site
1064535000220	ABC transporter signature motif; other site
1064535000221	Walker B; other site
1064535000222	D-loop; other site
1064535000223	H-loop/switch region; other site
1064535000224	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1064535000225	High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646
1064535000226	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535000227	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1064535000228	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1064535000229	active site
1064535000230	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1064535000231	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535000232	active site
1064535000233	motif I; other site
1064535000234	motif II; other site
1064535000235	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535000236	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1064535000237	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1064535000238	active site
1064535000239	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
1064535000240	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1064535000241	active site
1064535000242	catalytic residues [active]
1064535000243	metal binding site [ion binding]; metal-binding site
1064535000244	homodimer binding site [polypeptide binding]; other site
1064535000245	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1064535000246	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535000247	FeS/SAM binding site; other site
1064535000248	ribonuclease III; Reviewed; Region: rnc; PRK00102
1064535000249	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1064535000250	dimerization interface [polypeptide binding]; other site
1064535000251	active site
1064535000252	metal binding site [ion binding]; metal-binding site
1064535000253	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1064535000254	dsRNA binding site [nucleotide binding]; other site
1064535000255	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1064535000256	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1064535000257	dimer interface [polypeptide binding]; other site
1064535000258	active site
1064535000259	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1064535000260	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1064535000261	FMN binding site [chemical binding]; other site
1064535000262	substrate binding site [chemical binding]; other site
1064535000263	putative catalytic residue [active]
1064535000264	acyl carrier protein; Provisional; Region: acpP; PRK00982
1064535000265	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1064535000266	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1064535000267	NAD(P) binding site [chemical binding]; other site
1064535000268	homotetramer interface [polypeptide binding]; other site
1064535000269	homodimer interface [polypeptide binding]; other site
1064535000270	active site
1064535000271	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1064535000272	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1064535000273	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1064535000274	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1064535000275	dimer interface [polypeptide binding]; other site
1064535000276	active site
1064535000277	CoA binding pocket [chemical binding]; other site
1064535000278	putative phosphate acyltransferase; Provisional; Region: PRK05331
1064535000279	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1064535000280	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1064535000281	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1064535000282	active site 2 [active]
1064535000283	active site 1 [active]
1064535000284	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
1064535000285	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1064535000286	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1064535000287	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1064535000288	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
1064535000289	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
1064535000290	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
1064535000291	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
1064535000292	Predicted permeases [General function prediction only]; Region: COG0795
1064535000293	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1064535000294	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1064535000295	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1064535000296	Walker A/P-loop; other site
1064535000297	ATP binding site [chemical binding]; other site
1064535000298	Q-loop/lid; other site
1064535000299	ABC transporter signature motif; other site
1064535000300	Walker B; other site
1064535000301	D-loop; other site
1064535000302	H-loop/switch region; other site
1064535000303	OstA-like protein; Region: OstA; cl00844
1064535000304	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1064535000305	OstA-like protein; Region: OstA; cl00844
1064535000306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
1064535000307	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1064535000308	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1064535000309	putative acyl-acceptor binding pocket; other site
1064535000310	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1064535000311	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535000312	active site
1064535000313	motif I; other site
1064535000314	motif II; other site
1064535000315	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1064535000316	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1064535000317	putative active site [active]
1064535000318	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1064535000319	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1064535000320	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1064535000321	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1064535000322	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1064535000323	Ligand binding site; other site
1064535000324	oligomer interface; other site
1064535000325	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
1064535000326	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1064535000327	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1064535000328	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1064535000329	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1064535000330	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1064535000331	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1064535000332	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1064535000333	Walker A/P-loop; other site
1064535000334	ATP binding site [chemical binding]; other site
1064535000335	Q-loop/lid; other site
1064535000336	ABC transporter signature motif; other site
1064535000337	Walker B; other site
1064535000338	D-loop; other site
1064535000339	H-loop/switch region; other site
1064535000340	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1064535000341	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1064535000342	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
1064535000343	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1064535000344	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1064535000345	active site
1064535000346	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1064535000347	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1064535000348	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1064535000349	argininosuccinate lyase; Provisional; Region: PRK00855
1064535000350	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1064535000351	active sites [active]
1064535000352	tetramer interface [polypeptide binding]; other site
1064535000353	argininosuccinate synthase; Provisional; Region: PRK13820
1064535000354	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1064535000355	ANP binding site [chemical binding]; other site
1064535000356	Substrate Binding Site II [chemical binding]; other site
1064535000357	Substrate Binding Site I [chemical binding]; other site
1064535000358	Transglycosylase; Region: Transgly; pfam00912
1064535000359	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535000360	FAD binding domain; Region: FAD_binding_4; pfam01565
1064535000361	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1064535000362	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
1064535000363	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1064535000364	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1064535000365	DNA-binding site [nucleotide binding]; DNA binding site
1064535000366	FCD domain; Region: FCD; pfam07729
1064535000367	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1064535000368	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1064535000369	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1064535000370	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1064535000371	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1064535000372	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1064535000373	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1064535000374	PhoU domain; Region: PhoU; pfam01895
1064535000375	PhoU domain; Region: PhoU; pfam01895
1064535000376	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
1064535000377	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1064535000378	Walker A/P-loop; other site
1064535000379	ATP binding site [chemical binding]; other site
1064535000380	Q-loop/lid; other site
1064535000381	ABC transporter signature motif; other site
1064535000382	Walker B; other site
1064535000383	D-loop; other site
1064535000384	H-loop/switch region; other site
1064535000385	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1064535000386	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535000387	dimer interface [polypeptide binding]; other site
1064535000388	conserved gate region; other site
1064535000389	putative PBP binding loops; other site
1064535000390	ABC-ATPase subunit interface; other site
1064535000391	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1064535000392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535000393	dimer interface [polypeptide binding]; other site
1064535000394	conserved gate region; other site
1064535000395	ABC-ATPase subunit interface; other site
1064535000396	PBP superfamily domain; Region: PBP_like_2; cl17296
1064535000397	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1064535000398	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1064535000399	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1064535000400	dimer interface [polypeptide binding]; other site
1064535000401	phosphorylation site [posttranslational modification]
1064535000402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1064535000403	ATP binding site [chemical binding]; other site
1064535000404	Mg2+ binding site [ion binding]; other site
1064535000405	G-X-G motif; other site
1064535000406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535000407	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1064535000408	active site
1064535000409	phosphorylation site [posttranslational modification]
1064535000410	intermolecular recognition site; other site
1064535000411	dimerization interface [polypeptide binding]; other site
1064535000412	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1064535000413	DNA binding site [nucleotide binding]
1064535000414	OstA-like protein; Region: OstA; cl00844
1064535000415	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
1064535000416	Rubredoxin; Region: Rubredoxin; pfam00301
1064535000417	iron binding site [ion binding]; other site
1064535000418	Rubrerythrin [Energy production and conversion]; Region: COG1592
1064535000419	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
1064535000420	diiron binding motif [ion binding]; other site
1064535000421	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535000422	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535000423	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1064535000424	dimerization interface [polypeptide binding]; other site
1064535000425	universal stress protein UspE; Provisional; Region: PRK11175
1064535000426	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1064535000427	Ligand Binding Site [chemical binding]; other site
1064535000428	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1064535000429	Ligand Binding Site [chemical binding]; other site
1064535000430	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
1064535000431	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535000432	FeS/SAM binding site; other site
1064535000433	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1064535000434	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1064535000435	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
1064535000436	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1064535000437	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1064535000438	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1064535000439	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1064535000440	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1064535000441	dimerization interface 3.5A [polypeptide binding]; other site
1064535000442	active site
1064535000443	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1064535000444	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
1064535000445	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1064535000446	Walker A/P-loop; other site
1064535000447	ATP binding site [chemical binding]; other site
1064535000448	Q-loop/lid; other site
1064535000449	ABC transporter signature motif; other site
1064535000450	Walker B; other site
1064535000451	D-loop; other site
1064535000452	H-loop/switch region; other site
1064535000453	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
1064535000454	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1064535000455	Walker A/P-loop; other site
1064535000456	ATP binding site [chemical binding]; other site
1064535000457	Q-loop/lid; other site
1064535000458	ABC transporter signature motif; other site
1064535000459	Walker B; other site
1064535000460	D-loop; other site
1064535000461	H-loop/switch region; other site
1064535000462	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1064535000463	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1064535000464	G1 box; other site
1064535000465	GTP/Mg2+ binding site [chemical binding]; other site
1064535000466	Switch I region; other site
1064535000467	G2 box; other site
1064535000468	G3 box; other site
1064535000469	Switch II region; other site
1064535000470	G4 box; other site
1064535000471	G5 box; other site
1064535000472	Nucleoside recognition; Region: Gate; pfam07670
1064535000473	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1064535000474	Nucleoside recognition; Region: Gate; pfam07670
1064535000475	FeoA domain; Region: FeoA; pfam04023
1064535000476	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1064535000477	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1064535000478	AAA domain; Region: AAA_22; pfam13401
1064535000479	AAA domain; Region: AAA_17; cl17253
1064535000480	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1064535000481	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1064535000482	dimer interface [polypeptide binding]; other site
1064535000483	putative anticodon binding site; other site
1064535000484	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1064535000485	motif 1; other site
1064535000486	active site
1064535000487	motif 2; other site
1064535000488	motif 3; other site
1064535000489	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1064535000490	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1064535000491	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1064535000492	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1064535000493	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1064535000494	FMN binding site [chemical binding]; other site
1064535000495	active site
1064535000496	catalytic residues [active]
1064535000497	substrate binding site [chemical binding]; other site
1064535000498	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1064535000499	nucleotide binding site [chemical binding]; other site
1064535000500	Type III pantothenate kinase; Region: Pan_kinase; cl17198
1064535000501	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1064535000502	putative DNA binding site [nucleotide binding]; other site
1064535000503	dimerization interface [polypeptide binding]; other site
1064535000504	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1064535000505	putative Zn2+ binding site [ion binding]; other site
1064535000506	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1064535000507	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1064535000508	FtsH Extracellular; Region: FtsH_ext; pfam06480
1064535000509	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1064535000510	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535000511	Walker A motif; other site
1064535000512	ATP binding site [chemical binding]; other site
1064535000513	Walker B motif; other site
1064535000514	arginine finger; other site
1064535000515	Peptidase family M41; Region: Peptidase_M41; pfam01434
1064535000516	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1064535000517	active site
1064535000518	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1064535000519	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1064535000520	Ligand Binding Site [chemical binding]; other site
1064535000521	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1064535000522	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1064535000523	hypothetical protein; Provisional; Region: PRK08582
1064535000524	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1064535000525	RNA binding site [nucleotide binding]; other site
1064535000526	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1064535000527	FAD binding domain; Region: FAD_binding_4; pfam01565
1064535000528	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1064535000529	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1064535000530	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1064535000531	dimerization interface [polypeptide binding]; other site
1064535000532	active site
1064535000533	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1064535000534	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1064535000535	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1064535000536	putative switch regulator; other site
1064535000537	non-specific DNA interactions [nucleotide binding]; other site
1064535000538	DNA binding site [nucleotide binding]
1064535000539	sequence specific DNA binding site [nucleotide binding]; other site
1064535000540	putative cAMP binding site [chemical binding]; other site
1064535000541	Ferredoxin [Energy production and conversion]; Region: COG1146
1064535000542	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1064535000543	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1064535000544	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1064535000545	putative Zn2+ binding site [ion binding]; other site
1064535000546	putative DNA binding site [nucleotide binding]; other site
1064535000547	AsnC family; Region: AsnC_trans_reg; pfam01037
1064535000548	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1064535000549	ApbE family; Region: ApbE; pfam02424
1064535000550	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1064535000551	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1064535000552	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1064535000553	ferredoxin; Validated; Region: PRK07118
1064535000554	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
1064535000555	electron transport complex RsxE subunit; Provisional; Region: PRK12405
1064535000556	FMN-binding domain; Region: FMN_bind; cl01081
1064535000557	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
1064535000558	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
1064535000559	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1064535000560	SLBB domain; Region: SLBB; pfam10531
1064535000561	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1064535000562	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1064535000563	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1064535000564	CTP synthetase; Validated; Region: pyrG; PRK05380
1064535000565	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1064535000566	Catalytic site [active]
1064535000567	active site
1064535000568	UTP binding site [chemical binding]; other site
1064535000569	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1064535000570	active site
1064535000571	putative oxyanion hole; other site
1064535000572	catalytic triad [active]
1064535000573	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1064535000574	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1064535000575	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1064535000576	active site
1064535000577	HIGH motif; other site
1064535000578	KMSK motif region; other site
1064535000579	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1064535000580	tRNA binding surface [nucleotide binding]; other site
1064535000581	anticodon binding site; other site
1064535000582	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
1064535000583	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1064535000584	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1064535000585	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535000586	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1064535000587	Ligand Binding Site [chemical binding]; other site
1064535000588	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1064535000589	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1064535000590	transmembrane helices; other site
1064535000591	spermidine synthase; Provisional; Region: PRK00811
1064535000592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535000593	S-adenosylmethionine binding site [chemical binding]; other site
1064535000594	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1064535000595	nucleotide binding site [chemical binding]; other site
1064535000596	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1064535000597	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
1064535000598	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1064535000599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
1064535000600	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
1064535000601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
1064535000602	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1064535000603	Ligand Binding Site [chemical binding]; other site
1064535000604	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1064535000605	Ligand Binding Site [chemical binding]; other site
1064535000606	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
1064535000607	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1064535000608	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1064535000609	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1064535000610	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1064535000611	catalytic loop [active]
1064535000612	iron binding site [ion binding]; other site
1064535000613	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1064535000614	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1064535000615	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1064535000616	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1064535000617	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1064535000618	metal binding site [ion binding]; metal-binding site
1064535000619	active site
1064535000620	I-site; other site
1064535000621	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1064535000622	active site
1064535000623	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535000624	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
1064535000625	Probable transposase; Region: OrfB_IS605; pfam01385
1064535000626	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535000627	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1064535000628	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1064535000629	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1064535000630	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1064535000631	active site
1064535000632	Domain of unknown function DUF77; Region: DUF77; pfam01910
1064535000633	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1064535000634	substrate binding site [chemical binding]; other site
1064535000635	multimerization interface [polypeptide binding]; other site
1064535000636	ATP binding site [chemical binding]; other site
1064535000637	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1064535000638	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1064535000639	substrate binding pocket [chemical binding]; other site
1064535000640	membrane-bound complex binding site; other site
1064535000641	hinge residues; other site
1064535000642	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1064535000643	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535000644	motif II; other site
1064535000645	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1064535000646	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1064535000647	substrate binding pocket [chemical binding]; other site
1064535000648	membrane-bound complex binding site; other site
1064535000649	hinge residues; other site
1064535000650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1064535000651	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1064535000652	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1064535000653	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1064535000654	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1064535000655	phosphate binding site [ion binding]; other site
1064535000656	putative substrate binding pocket [chemical binding]; other site
1064535000657	dimer interface [polypeptide binding]; other site
1064535000658	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1064535000659	shikimate kinase; Reviewed; Region: aroK; PRK00131
1064535000660	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1064535000661	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535000662	active site
1064535000663	motif I; other site
1064535000664	motif II; other site
1064535000665	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535000666	DivIVA protein; Region: DivIVA; pfam05103
1064535000667	DivIVA domain; Region: DivI1A_domain; TIGR03544
1064535000668	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1064535000669	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1064535000670	RNA binding surface [nucleotide binding]; other site
1064535000671	Protein of unknown function (DUF552); Region: DUF552; pfam04472
1064535000672	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1064535000673	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1064535000674	catalytic residue [active]
1064535000675	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1064535000676	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1064535000677	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
1064535000678	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1064535000679	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535000680	FeS/SAM binding site; other site
1064535000681	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1064535000682	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1064535000683	Na binding site [ion binding]; other site
1064535000684	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
1064535000685	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1064535000686	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1064535000687	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1064535000688	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1064535000689	NAD binding site [chemical binding]; other site
1064535000690	homodimer interface [polypeptide binding]; other site
1064535000691	active site
1064535000692	substrate binding site [chemical binding]; other site
1064535000693	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
1064535000694	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1064535000695	active site
1064535000696	dimer interface [polypeptide binding]; other site
1064535000697	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1064535000698	dimer interface [polypeptide binding]; other site
1064535000699	active site
1064535000700	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1064535000701	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1064535000702	Walker A/P-loop; other site
1064535000703	ATP binding site [chemical binding]; other site
1064535000704	Q-loop/lid; other site
1064535000705	ABC transporter signature motif; other site
1064535000706	Walker B; other site
1064535000707	D-loop; other site
1064535000708	H-loop/switch region; other site
1064535000709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535000710	dimer interface [polypeptide binding]; other site
1064535000711	conserved gate region; other site
1064535000712	putative PBP binding loops; other site
1064535000713	ABC-ATPase subunit interface; other site
1064535000714	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1064535000715	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1064535000716	substrate binding pocket [chemical binding]; other site
1064535000717	membrane-bound complex binding site; other site
1064535000718	hinge residues; other site
1064535000719	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1064535000720	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1064535000721	substrate binding pocket [chemical binding]; other site
1064535000722	membrane-bound complex binding site; other site
1064535000723	hinge residues; other site
1064535000724	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
1064535000725	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1064535000726	putative active site [active]
1064535000727	putative metal binding site [ion binding]; other site
1064535000728	C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299
1064535000729	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1064535000730	ligand binding site [chemical binding]; other site
1064535000731	NAD binding site [chemical binding]; other site
1064535000732	catalytic site [active]
1064535000733	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
1064535000734	Int/Topo IB signature motif; other site
1064535000735	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1064535000736	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535000737	non-specific DNA binding site [nucleotide binding]; other site
1064535000738	salt bridge; other site
1064535000739	sequence-specific DNA binding site [nucleotide binding]; other site
1064535000740	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535000741	non-specific DNA binding site [nucleotide binding]; other site
1064535000742	salt bridge; other site
1064535000743	sequence-specific DNA binding site [nucleotide binding]; other site
1064535000744	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
1064535000745	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535000746	non-specific DNA binding site [nucleotide binding]; other site
1064535000747	salt bridge; other site
1064535000748	sequence-specific DNA binding site [nucleotide binding]; other site
1064535000749	MobA/MobL family; Region: MobA_MobL; pfam03389
1064535000750	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
1064535000751	biotin synthase; Provisional; Region: PRK07094
1064535000752	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535000753	FeS/SAM binding site; other site
1064535000754	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1064535000755	uracil transporter; Provisional; Region: PRK10720
1064535000756	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1064535000757	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535000758	S-adenosylmethionine binding site [chemical binding]; other site
1064535000759	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1064535000760	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1064535000761	active site
1064535000762	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1064535000763	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535000764	motif II; other site
1064535000765	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1064535000766	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1064535000767	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1064535000768	metal binding site [ion binding]; metal-binding site
1064535000769	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1064535000770	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1064535000771	substrate binding site [chemical binding]; other site
1064535000772	glutamase interaction surface [polypeptide binding]; other site
1064535000773	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1064535000774	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1064535000775	catalytic residues [active]
1064535000776	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1064535000777	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1064535000778	putative active site [active]
1064535000779	oxyanion strand; other site
1064535000780	catalytic triad [active]
1064535000781	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1064535000782	putative active site pocket [active]
1064535000783	4-fold oligomerization interface [polypeptide binding]; other site
1064535000784	metal binding residues [ion binding]; metal-binding site
1064535000785	3-fold/trimer interface [polypeptide binding]; other site
1064535000786	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
1064535000787	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535000788	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535000789	homodimer interface [polypeptide binding]; other site
1064535000790	catalytic residue [active]
1064535000791	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1064535000792	histidinol dehydrogenase; Region: hisD; TIGR00069
1064535000793	NAD binding site [chemical binding]; other site
1064535000794	dimerization interface [polypeptide binding]; other site
1064535000795	product binding site; other site
1064535000796	substrate binding site [chemical binding]; other site
1064535000797	zinc binding site [ion binding]; other site
1064535000798	catalytic residues [active]
1064535000799	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1064535000800	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1064535000801	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1064535000802	dimer interface [polypeptide binding]; other site
1064535000803	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
1064535000804	motif 1; other site
1064535000805	active site
1064535000806	motif 2; other site
1064535000807	motif 3; other site
1064535000808	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1064535000809	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
1064535000810	Rubrerythrin [Energy production and conversion]; Region: COG1592
1064535000811	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
1064535000812	binuclear metal center [ion binding]; other site
1064535000813	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
1064535000814	iron binding site [ion binding]; other site
1064535000815	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1064535000816	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535000817	active site
1064535000818	phosphorylation site [posttranslational modification]
1064535000819	intermolecular recognition site; other site
1064535000820	dimerization interface [polypeptide binding]; other site
1064535000821	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1064535000822	DNA binding site [nucleotide binding]
1064535000823	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1064535000824	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1064535000825	CpXC protein; Region: CpXC; pfam14353
1064535000826	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
1064535000827	ADP-ribose binding site [chemical binding]; other site
1064535000828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535000829	S-adenosylmethionine binding site [chemical binding]; other site
1064535000830	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
1064535000831	putative homodimer interface [polypeptide binding]; other site
1064535000832	putative homotetramer interface [polypeptide binding]; other site
1064535000833	putative metal binding site [ion binding]; other site
1064535000834	putative homodimer-homodimer interface [polypeptide binding]; other site
1064535000835	putative allosteric switch controlling residues; other site
1064535000836	Sulfatase; Region: Sulfatase; cl17466
1064535000837	hypothetical protein; Provisional; Region: PRK03881
1064535000838	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
1064535000839	AMMECR1; Region: AMMECR1; pfam01871
1064535000840	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
1064535000841	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535000842	FeS/SAM binding site; other site
1064535000843	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
1064535000844	Cupin domain; Region: Cupin_2; cl17218
1064535000845	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1064535000846	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1064535000847	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1064535000848	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1064535000849	substrate binding site [chemical binding]; other site
1064535000850	active site
1064535000851	catalytic residues [active]
1064535000852	heterodimer interface [polypeptide binding]; other site
1064535000853	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1064535000854	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1064535000855	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535000856	catalytic residue [active]
1064535000857	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1064535000858	active site
1064535000859	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1064535000860	active site
1064535000861	ribulose/triose binding site [chemical binding]; other site
1064535000862	phosphate binding site [ion binding]; other site
1064535000863	substrate (anthranilate) binding pocket [chemical binding]; other site
1064535000864	product (indole) binding pocket [chemical binding]; other site
1064535000865	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1064535000866	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1064535000867	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1064535000868	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1064535000869	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1064535000870	glutamine binding [chemical binding]; other site
1064535000871	catalytic triad [active]
1064535000872	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
1064535000873	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1064535000874	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1064535000875	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1064535000876	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1064535000877	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535000878	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535000879	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1064535000880	dimerization interface [polypeptide binding]; other site
1064535000881	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1064535000882	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1064535000883	dimer interface [polypeptide binding]; other site
1064535000884	PYR/PP interface [polypeptide binding]; other site
1064535000885	TPP binding site [chemical binding]; other site
1064535000886	substrate binding site [chemical binding]; other site
1064535000887	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1064535000888	Domain of unknown function; Region: EKR; pfam10371
1064535000889	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1064535000890	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1064535000891	TPP-binding site [chemical binding]; other site
1064535000892	dimer interface [polypeptide binding]; other site
1064535000893	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1064535000894	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1064535000895	catalytic residues [active]
1064535000896	dimer interface [polypeptide binding]; other site
1064535000897	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
1064535000898	non-heme iron binding site [ion binding]; other site
1064535000899	Autotransporter beta-domain; Region: Autotransporter; smart00869
1064535000900	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1064535000901	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1064535000902	putative active site [active]
1064535000903	catalytic residue [active]
1064535000904	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1064535000905	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1064535000906	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1064535000907	active site
1064535000908	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1064535000909	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1064535000910	Substrate binding site; other site
1064535000911	Mg++ binding site; other site
1064535000912	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1064535000913	active site
1064535000914	substrate binding site [chemical binding]; other site
1064535000915	CoA binding site [chemical binding]; other site
1064535000916	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1064535000917	3D domain; Region: 3D; cl01439
1064535000918	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1064535000919	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1064535000920	Cl- selectivity filter; other site
1064535000921	Cl- binding residues [ion binding]; other site
1064535000922	pore gating glutamate residue; other site
1064535000923	dimer interface [polypeptide binding]; other site
1064535000924	H+/Cl- coupling transport residue; other site
1064535000925	TrkA-C domain; Region: TrkA_C; pfam02080
1064535000926	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1064535000927	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1064535000928	metal binding site [ion binding]; metal-binding site
1064535000929	dimer interface [polypeptide binding]; other site
1064535000930	Membrane transport protein; Region: Mem_trans; cl09117
1064535000931	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1064535000932	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
1064535000933	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1064535000934	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1064535000935	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1064535000936	active site
1064535000937	catalytic residue [active]
1064535000938	dimer interface [polypeptide binding]; other site
1064535000939	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535000940	putative substrate translocation pore; other site
1064535000941	shikimate kinase; Reviewed; Region: aroK; PRK00131
1064535000942	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1064535000943	ADP binding site [chemical binding]; other site
1064535000944	magnesium binding site [ion binding]; other site
1064535000945	putative shikimate binding site; other site
1064535000946	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1064535000947	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1064535000948	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1064535000949	shikimate binding site; other site
1064535000950	NAD(P) binding site [chemical binding]; other site
1064535000951	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1064535000952	Prephenate dehydratase; Region: PDT; pfam00800
1064535000953	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1064535000954	putative L-Phe binding site [chemical binding]; other site
1064535000955	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1064535000956	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1064535000957	Tetramer interface [polypeptide binding]; other site
1064535000958	active site
1064535000959	FMN-binding site [chemical binding]; other site
1064535000960	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1064535000961	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1064535000962	hinge; other site
1064535000963	active site
1064535000964	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1064535000965	active site
1064535000966	dimer interface [polypeptide binding]; other site
1064535000967	metal binding site [ion binding]; metal-binding site
1064535000968	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
1064535000969	prephenate dehydrogenase; Validated; Region: PRK08507
1064535000970	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
1064535000971	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1064535000972	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1064535000973	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1064535000974	NodB motif; other site
1064535000975	active site
1064535000976	catalytic site [active]
1064535000977	Zn binding site [ion binding]; other site
1064535000978	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
1064535000979	putative oxidoreductase; Provisional; Region: PRK09799
1064535000980	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
1064535000981	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1064535000982	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1064535000983	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1064535000984	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1064535000985	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
1064535000986	putative L-serine binding site [chemical binding]; other site
1064535000987	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1064535000988	Part of AAA domain; Region: AAA_19; pfam13245
1064535000989	Family description; Region: UvrD_C_2; pfam13538
1064535000990	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1064535000991	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1064535000992	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1064535000993	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
1064535000994	FeS/SAM binding site; other site
1064535000995	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1064535000996	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1064535000997	Bacterial transcriptional regulator; Region: IclR; pfam01614
1064535000998	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1064535000999	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535001000	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535001001	homodimer interface [polypeptide binding]; other site
1064535001002	catalytic residue [active]
1064535001003	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1064535001004	MgtC family; Region: MgtC; pfam02308
1064535001005	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1064535001006	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1064535001007	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1064535001008	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1064535001009	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1064535001010	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1064535001011	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
1064535001012	putative uracil binding site [chemical binding]; other site
1064535001013	putative active site [active]
1064535001014	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1064535001015	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1064535001016	active site
1064535001017	dimer interface [polypeptide binding]; other site
1064535001018	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1064535001019	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1064535001020	active site
1064535001021	FMN binding site [chemical binding]; other site
1064535001022	substrate binding site [chemical binding]; other site
1064535001023	3Fe-4S cluster binding site [ion binding]; other site
1064535001024	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1064535001025	domain interface; other site
1064535001026	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1064535001027	EamA-like transporter family; Region: EamA; pfam00892
1064535001028	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1064535001029	EamA-like transporter family; Region: EamA; pfam00892
1064535001030	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1064535001031	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535001032	FeS/SAM binding site; other site
1064535001033	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1064535001034	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1064535001035	metal binding site [ion binding]; metal-binding site
1064535001036	active site
1064535001037	I-site; other site
1064535001038	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1064535001039	Sodium Bile acid symporter family; Region: SBF; pfam01758
1064535001040	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
1064535001041	putative uracil binding site [chemical binding]; other site
1064535001042	putative active site [active]
1064535001043	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1064535001044	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1064535001045	Sodium Bile acid symporter family; Region: SBF; pfam01758
1064535001046	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1064535001047	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1064535001048	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1064535001049	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1064535001050	putative valine binding site [chemical binding]; other site
1064535001051	dimer interface [polypeptide binding]; other site
1064535001052	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1064535001053	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
1064535001054	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1064535001055	PYR/PP interface [polypeptide binding]; other site
1064535001056	dimer interface [polypeptide binding]; other site
1064535001057	TPP binding site [chemical binding]; other site
1064535001058	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1064535001059	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1064535001060	TPP-binding site [chemical binding]; other site
1064535001061	dimer interface [polypeptide binding]; other site
1064535001062	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1064535001063	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1064535001064	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1064535001065	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1064535001066	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535001067	Walker A motif; other site
1064535001068	ATP binding site [chemical binding]; other site
1064535001069	Walker B motif; other site
1064535001070	arginine finger; other site
1064535001071	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1064535001072	dihydropteroate synthase; Region: DHPS; TIGR01496
1064535001073	substrate binding pocket [chemical binding]; other site
1064535001074	dimer interface [polypeptide binding]; other site
1064535001075	inhibitor binding site; inhibition site
1064535001076	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1064535001077	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1064535001078	putative active site [active]
1064535001079	metal binding site [ion binding]; metal-binding site
1064535001080	AAA domain; Region: AAA_23; pfam13476
1064535001081	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1064535001082	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1064535001083	active site
1064535001084	metal binding site [ion binding]; metal-binding site
1064535001085	DNA binding site [nucleotide binding]
1064535001086	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1064535001087	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1064535001088	DNA-binding site [nucleotide binding]; DNA binding site
1064535001089	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535001090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535001091	homodimer interface [polypeptide binding]; other site
1064535001092	catalytic residue [active]
1064535001093	hexokinase; Provisional; Region: PTZ00107
1064535001094	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1064535001095	nucleotide binding site [chemical binding]; other site
1064535001096	Hexokinase; Region: Hexokinase_2; pfam03727
1064535001097	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1064535001098	thiS-thiF/thiG interaction site; other site
1064535001099	thiazole synthase; Reviewed; Region: thiG; PRK00208
1064535001100	phosphate binding site [ion binding]; other site
1064535001101	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
1064535001102	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535001103	FeS/SAM binding site; other site
1064535001104	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1064535001105	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1064535001106	thiamine phosphate binding site [chemical binding]; other site
1064535001107	active site
1064535001108	pyrophosphate binding site [ion binding]; other site
1064535001109	Isochorismatase family; Region: Isochorismatase; pfam00857
1064535001110	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1064535001111	catalytic triad [active]
1064535001112	conserved cis-peptide bond; other site
1064535001113	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
1064535001114	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1064535001115	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1064535001116	active site 2 [active]
1064535001117	active site 1 [active]
1064535001118	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
1064535001119	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535001120	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1064535001121	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
1064535001122	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1064535001123	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
1064535001124	active site turn [active]
1064535001125	phosphorylation site [posttranslational modification]
1064535001126	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1064535001127	HPr interaction site; other site
1064535001128	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1064535001129	active site
1064535001130	phosphorylation site [posttranslational modification]
1064535001131	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1064535001132	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1064535001133	active site
1064535001134	NAD binding site [chemical binding]; other site
1064535001135	metal binding site [ion binding]; metal-binding site
1064535001136	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1064535001137	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1064535001138	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1064535001139	dimer interface [polypeptide binding]; other site
1064535001140	active site
1064535001141	metal binding site [ion binding]; metal-binding site
1064535001142	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
1064535001143	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1064535001144	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1064535001145	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
1064535001146	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1064535001147	NifU-like domain; Region: NifU; cl00484
1064535001148	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
1064535001149	dimer interaction site [polypeptide binding]; other site
1064535001150	substrate-binding tunnel; other site
1064535001151	active site
1064535001152	catalytic site [active]
1064535001153	substrate binding site [chemical binding]; other site
1064535001154	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1064535001155	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
1064535001156	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1064535001157	NAD(P) binding site [chemical binding]; other site
1064535001158	catalytic residues [active]
1064535001159	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1064535001160	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1064535001161	acyl-activating enzyme (AAE) consensus motif; other site
1064535001162	AMP binding site [chemical binding]; other site
1064535001163	active site
1064535001164	CoA binding site [chemical binding]; other site
1064535001165	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1064535001166	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
1064535001167	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1064535001168	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1064535001169	PAS domain S-box; Region: sensory_box; TIGR00229
1064535001170	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1064535001171	putative active site [active]
1064535001172	heme pocket [chemical binding]; other site
1064535001173	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1064535001174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535001175	Walker A motif; other site
1064535001176	ATP binding site [chemical binding]; other site
1064535001177	Walker B motif; other site
1064535001178	arginine finger; other site
1064535001179	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1064535001180	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1064535001181	active site
1064535001182	substrate binding site [chemical binding]; other site
1064535001183	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1064535001184	FMN binding site [chemical binding]; other site
1064535001185	putative catalytic residues [active]
1064535001186	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
1064535001187	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1064535001188	NADP binding site [chemical binding]; other site
1064535001189	homodimer interface [polypeptide binding]; other site
1064535001190	active site
1064535001191	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
1064535001192	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
1064535001193	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1064535001194	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1064535001195	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1064535001196	YheO-like PAS domain; Region: PAS_6; pfam08348
1064535001197	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1064535001198	DNA-binding interface [nucleotide binding]; DNA binding site
1064535001199	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1064535001200	homotrimer interaction site [polypeptide binding]; other site
1064535001201	putative active site [active]
1064535001202	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535001203	Probable transposase; Region: OrfB_IS605; pfam01385
1064535001204	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535001205	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1064535001206	DNA binding residues [nucleotide binding]
1064535001207	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1064535001208	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1064535001209	Walker A motif; other site
1064535001210	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1064535001211	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1064535001212	dimer interface [polypeptide binding]; other site
1064535001213	Alkaline phosphatase homologues; Region: alkPPc; smart00098
1064535001214	active site
1064535001215	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
1064535001216	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1064535001217	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1064535001218	nucleotide binding site [chemical binding]; other site
1064535001219	Acetokinase family; Region: Acetate_kinase; cl17229
1064535001220	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1064535001221	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1064535001222	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1064535001223	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1064535001224	active site
1064535001225	dimer interface [polypeptide binding]; other site
1064535001226	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1064535001227	active site
1064535001228	DNA polymerase IV; Validated; Region: PRK02406
1064535001229	DNA binding site [nucleotide binding]
1064535001230	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535001231	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535001232	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1064535001233	dimerization interface [polypeptide binding]; other site
1064535001234	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1064535001235	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1064535001236	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1064535001237	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1064535001238	NlpC/P60 family; Region: NLPC_P60; pfam00877
1064535001239	GGGtGRT protein; Region: GGGtGRT; pfam14057
1064535001240	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1064535001241	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
1064535001242	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535001243	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535001244	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1064535001245	dimerization interface [polypeptide binding]; other site
1064535001246	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1064535001247	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535001248	Walker A motif; other site
1064535001249	ATP binding site [chemical binding]; other site
1064535001250	Walker B motif; other site
1064535001251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
1064535001252	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
1064535001253	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1064535001254	S-layer homology domain; Region: SLH; pfam00395
1064535001255	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1064535001256	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535001257	active site
1064535001258	motif I; other site
1064535001259	motif II; other site
1064535001260	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535001261	motif II; other site
1064535001262	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1064535001263	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1064535001264	Ca binding site [ion binding]; other site
1064535001265	active site
1064535001266	catalytic site [active]
1064535001267	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1064535001268	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1064535001269	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1064535001270	active site turn [active]
1064535001271	phosphorylation site [posttranslational modification]
1064535001272	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1064535001273	HPr interaction site; other site
1064535001274	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1064535001275	active site
1064535001276	phosphorylation site [posttranslational modification]
1064535001277	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1064535001278	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1064535001279	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1064535001280	putative active site [active]
1064535001281	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1064535001282	nucleotide binding site [chemical binding]; other site
1064535001283	Hexokinase; Region: Hexokinase_2; pfam03727
1064535001284	TIGR04076 family protein; Region: TIGR04076
1064535001285	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1064535001286	active site
1064535001287	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1064535001288	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1064535001289	active site
1064535001290	HIGH motif; other site
1064535001291	KMSKS motif; other site
1064535001292	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1064535001293	tRNA binding surface [nucleotide binding]; other site
1064535001294	anticodon binding site; other site
1064535001295	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1064535001296	dimer interface [polypeptide binding]; other site
1064535001297	putative tRNA-binding site [nucleotide binding]; other site
1064535001298	Predicted methyltransferases [General function prediction only]; Region: COG0313
1064535001299	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1064535001300	putative SAM binding site [chemical binding]; other site
1064535001301	putative homodimer interface [polypeptide binding]; other site
1064535001302	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1064535001303	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535001304	S-adenosylmethionine binding site [chemical binding]; other site
1064535001305	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1064535001306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535001307	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
1064535001308	Walker A motif; other site
1064535001309	ATP binding site [chemical binding]; other site
1064535001310	Walker B motif; other site
1064535001311	arginine finger; other site
1064535001312	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1064535001313	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1064535001314	TMP-binding site; other site
1064535001315	ATP-binding site [chemical binding]; other site
1064535001316	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1064535001317	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1064535001318	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1064535001319	catalytic residue [active]
1064535001320	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1064535001321	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1064535001322	nudix motif; other site
1064535001323	pyridoxamine kinase; Validated; Region: PRK05756
1064535001324	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1064535001325	dimer interface [polypeptide binding]; other site
1064535001326	pyridoxal binding site [chemical binding]; other site
1064535001327	ATP binding site [chemical binding]; other site
1064535001328	BioY family; Region: BioY; pfam02632
1064535001329	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1064535001330	metal binding site [ion binding]; metal-binding site
1064535001331	active site
1064535001332	I-site; other site
1064535001333	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1064535001334	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1064535001335	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1064535001336	metal binding site [ion binding]; metal-binding site
1064535001337	active site
1064535001338	I-site; other site
1064535001339	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1064535001340	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1064535001341	metal binding site [ion binding]; metal-binding site
1064535001342	active site
1064535001343	I-site; other site
1064535001344	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
1064535001345	Divergent AAA domain; Region: AAA_4; pfam04326
1064535001346	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
1064535001347	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1064535001348	putative DNA binding site [nucleotide binding]; other site
1064535001349	putative Zn2+ binding site [ion binding]; other site
1064535001350	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1064535001351	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1064535001352	core dimer interface [polypeptide binding]; other site
1064535001353	peripheral dimer interface [polypeptide binding]; other site
1064535001354	L10 interface [polypeptide binding]; other site
1064535001355	L11 interface [polypeptide binding]; other site
1064535001356	putative EF-Tu interaction site [polypeptide binding]; other site
1064535001357	putative EF-G interaction site [polypeptide binding]; other site
1064535001358	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1064535001359	23S rRNA interface [nucleotide binding]; other site
1064535001360	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1064535001361	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1064535001362	mRNA/rRNA interface [nucleotide binding]; other site
1064535001363	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1064535001364	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1064535001365	23S rRNA interface [nucleotide binding]; other site
1064535001366	L7/L12 interface [polypeptide binding]; other site
1064535001367	putative thiostrepton binding site; other site
1064535001368	L25 interface [polypeptide binding]; other site
1064535001369	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1064535001370	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1064535001371	putative homodimer interface [polypeptide binding]; other site
1064535001372	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1064535001373	heterodimer interface [polypeptide binding]; other site
1064535001374	homodimer interface [polypeptide binding]; other site
1064535001375	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
1064535001376	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1064535001377	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552
1064535001378	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1064535001379	Aspartase; Region: Aspartase; cd01357
1064535001380	active sites [active]
1064535001381	tetramer interface [polypeptide binding]; other site
1064535001382	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
1064535001383	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
1064535001384	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185
1064535001385	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
1064535001386	putative active site [active]
1064535001387	metal binding site [ion binding]; metal-binding site
1064535001388	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1064535001389	metal-binding site [ion binding]
1064535001390	amino acid transporter; Region: 2A0306; TIGR00909
1064535001391	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1064535001392	enolase; Provisional; Region: eno; PRK00077
1064535001393	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1064535001394	dimer interface [polypeptide binding]; other site
1064535001395	metal binding site [ion binding]; metal-binding site
1064535001396	substrate binding pocket [chemical binding]; other site
1064535001397	DNA gyrase subunit A; Validated; Region: PRK05560
1064535001398	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1064535001399	CAP-like domain; other site
1064535001400	active site
1064535001401	primary dimer interface [polypeptide binding]; other site
1064535001402	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1064535001403	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1064535001404	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1064535001405	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1064535001406	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1064535001407	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1064535001408	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
1064535001409	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1064535001410	Coenzyme A transferase; Region: CoA_trans; cl17247
1064535001411	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1064535001412	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
1064535001413	elongation factor G; Reviewed; Region: PRK12740
1064535001414	G1 box; other site
1064535001415	putative GEF interaction site [polypeptide binding]; other site
1064535001416	GTP/Mg2+ binding site [chemical binding]; other site
1064535001417	Switch I region; other site
1064535001418	G2 box; other site
1064535001419	G3 box; other site
1064535001420	Switch II region; other site
1064535001421	G4 box; other site
1064535001422	G5 box; other site
1064535001423	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1064535001424	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
1064535001425	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1064535001426	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1064535001427	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1064535001428	metal binding site [ion binding]; metal-binding site
1064535001429	dimer interface [polypeptide binding]; other site
1064535001430	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
1064535001431	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1064535001432	oligomer interface [polypeptide binding]; other site
1064535001433	putative active site [active]
1064535001434	metal binding site [ion binding]; metal-binding site
1064535001435	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1064535001436	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
1064535001437	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1064535001438	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1064535001439	Walker A/P-loop; other site
1064535001440	ATP binding site [chemical binding]; other site
1064535001441	Q-loop/lid; other site
1064535001442	ABC transporter signature motif; other site
1064535001443	Walker B; other site
1064535001444	D-loop; other site
1064535001445	H-loop/switch region; other site
1064535001446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535001447	dimer interface [polypeptide binding]; other site
1064535001448	conserved gate region; other site
1064535001449	putative PBP binding loops; other site
1064535001450	ABC-ATPase subunit interface; other site
1064535001451	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1064535001452	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1064535001453	substrate binding pocket [chemical binding]; other site
1064535001454	membrane-bound complex binding site; other site
1064535001455	hinge residues; other site
1064535001456	proline racemase; Provisional; Region: PRK13969
1064535001457	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1064535001458	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
1064535001459	Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338
1064535001460	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
1064535001461	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535001462	sequence-specific DNA binding site [nucleotide binding]; other site
1064535001463	salt bridge; other site
1064535001464	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
1064535001465	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1064535001466	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1064535001467	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1064535001468	EamA-like transporter family; Region: EamA; pfam00892
1064535001469	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1064535001470	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1064535001471	putative active site [active]
1064535001472	homotrimer interaction site [polypeptide binding]; other site
1064535001473	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535001474	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1064535001475	Probable transposase; Region: OrfB_IS605; pfam01385
1064535001476	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535001477	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1064535001478	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1064535001479	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535001480	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535001481	homodimer interface [polypeptide binding]; other site
1064535001482	catalytic residue [active]
1064535001483	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1064535001484	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535001485	non-specific DNA binding site [nucleotide binding]; other site
1064535001486	salt bridge; other site
1064535001487	sequence-specific DNA binding site [nucleotide binding]; other site
1064535001488	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
1064535001489	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1064535001490	potential frameshift: common BLAST hit: gi|126699996|ref|YP_001088893.1| indolepyruvate oxidoreductase subunit
1064535001491	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1064535001492	TPP-binding site [chemical binding]; other site
1064535001493	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1064535001494	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1064535001495	Helix-turn-helix domain; Region: HTH_38; pfam13936
1064535001496	DNA-binding interface [nucleotide binding]; DNA binding site
1064535001497	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
1064535001498	Divergent AAA domain; Region: AAA_4; pfam04326
1064535001499	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
1064535001500	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1064535001501	putative DNA binding site [nucleotide binding]; other site
1064535001502	putative Zn2+ binding site [ion binding]; other site
1064535001503	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1064535001504	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
1064535001505	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1064535001506	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1064535001507	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1064535001508	Aspartase; Region: Aspartase; cd01357
1064535001509	active sites [active]
1064535001510	tetramer interface [polypeptide binding]; other site
1064535001511	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
1064535001512	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
1064535001513	G1 box; other site
1064535001514	GTP/Mg2+ binding site [chemical binding]; other site
1064535001515	Switch I region; other site
1064535001516	G2 box; other site
1064535001517	Switch II region; other site
1064535001518	G3 box; other site
1064535001519	G4 box; other site
1064535001520	G5 box; other site
1064535001521	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1064535001522	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142
1064535001523	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
1064535001524	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
1064535001525	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
1064535001526	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1064535001527	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1064535001528	dimerization interface [polypeptide binding]; other site
1064535001529	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1064535001530	ATP binding site [chemical binding]; other site
1064535001531	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
1064535001532	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
1064535001533	HupF/HypC family; Region: HupF_HypC; pfam01455
1064535001534	Acylphosphatase; Region: Acylphosphatase; pfam00708
1064535001535	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
1064535001536	HypF finger; Region: zf-HYPF; pfam07503
1064535001537	HypF finger; Region: zf-HYPF; pfam07503
1064535001538	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1064535001539	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
1064535001540	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
1064535001541	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
1064535001542	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1064535001543	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1064535001544	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
1064535001545	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1064535001546	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1064535001547	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
1064535001548	potential protein location (hypothetical protein MELS_0459 [Megasphaera elsdenii DSM 20460]) that overlaps RNA (5S-rRNA)
1064535001549	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
1064535001550	non-heme iron binding site [ion binding]; other site
1064535001551	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1064535001552	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1064535001553	FAD binding site [chemical binding]; other site
1064535001554	homotetramer interface [polypeptide binding]; other site
1064535001555	substrate binding pocket [chemical binding]; other site
1064535001556	catalytic base [active]
1064535001557	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
1064535001558	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1064535001559	substrate binding site [chemical binding]; other site
1064535001560	oxyanion hole (OAH) forming residues; other site
1064535001561	trimer interface [polypeptide binding]; other site
1064535001562	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1064535001563	Coenzyme A transferase; Region: CoA_trans; smart00882
1064535001564	Coenzyme A transferase; Region: CoA_trans; cl17247
1064535001565	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
1064535001566	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1064535001567	active site
1064535001568	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
1064535001569	active site
1064535001570	N-terminal domain interface [polypeptide binding]; other site
1064535001571	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1064535001572	Ferritin-like domain; Region: Ferritin; pfam00210
1064535001573	ferroxidase diiron center [ion binding]; other site
1064535001574	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
1064535001575	Family of unknown function (DUF490); Region: DUF490; pfam04357
1064535001576	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1064535001577	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535001578	dimer interface [polypeptide binding]; other site
1064535001579	conserved gate region; other site
1064535001580	putative PBP binding loops; other site
1064535001581	ABC-ATPase subunit interface; other site
1064535001582	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1064535001583	Double zinc ribbon; Region: DZR; pfam12773
1064535001584	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1064535001585	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
1064535001586	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1064535001587	Coenzyme A binding pocket [chemical binding]; other site
1064535001588	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1064535001589	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
1064535001590	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1064535001591	active site
1064535001592	DNA binding site [nucleotide binding]
1064535001593	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1064535001594	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1064535001595	Bacterial transcriptional regulator; Region: IclR; pfam01614
1064535001596	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1064535001597	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1064535001598	HlyD family secretion protein; Region: HlyD_3; pfam13437
1064535001599	recombination protein RecR; Reviewed; Region: recR; PRK00076
1064535001600	RecR protein; Region: RecR; pfam02132
1064535001601	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1064535001602	putative active site [active]
1064535001603	putative metal-binding site [ion binding]; other site
1064535001604	tetramer interface [polypeptide binding]; other site
1064535001605	hypothetical protein; Validated; Region: PRK00153
1064535001606	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1064535001607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535001608	Walker A motif; other site
1064535001609	ATP binding site [chemical binding]; other site
1064535001610	Walker B motif; other site
1064535001611	arginine finger; other site
1064535001612	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1064535001613	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1064535001614	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1064535001615	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1064535001616	ligand binding site [chemical binding]; other site
1064535001617	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1064535001618	metal binding site [ion binding]; metal-binding site
1064535001619	Predicted membrane protein [Function unknown]; Region: COG2246
1064535001620	GtrA-like protein; Region: GtrA; pfam04138
1064535001621	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1064535001622	MarR family; Region: MarR; pfam01047
1064535001623	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1064535001624	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1064535001625	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
1064535001626	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1064535001627	DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489
1064535001628	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
1064535001629	GIY-YIG motif/motif A; other site
1064535001630	putative active site [active]
1064535001631	putative metal binding site [ion binding]; other site
1064535001632	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1064535001633	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1064535001634	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1064535001635	Cupin domain; Region: Cupin_2; cl17218
1064535001636	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1064535001637	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1064535001638	putative hydratase; Provisional; Region: PRK11413
1064535001639	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1064535001640	substrate binding site [chemical binding]; other site
1064535001641	ligand binding site [chemical binding]; other site
1064535001642	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
1064535001643	substrate binding site [chemical binding]; other site
1064535001644	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
1064535001645	Citrate synthase; Region: Citrate_synt; pfam00285
1064535001646	oxalacetate binding site [chemical binding]; other site
1064535001647	citrylCoA binding site [chemical binding]; other site
1064535001648	coenzyme A binding site [chemical binding]; other site
1064535001649	catalytic triad [active]
1064535001650	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1064535001651	isocitrate dehydrogenase; Validated; Region: PRK06451
1064535001652	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1064535001653	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1064535001654	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1064535001655	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408
1064535001656	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1064535001657	Domain of unknown function DUF21; Region: DUF21; pfam01595
1064535001658	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1064535001659	Transporter associated domain; Region: CorC_HlyC; smart01091
1064535001660	hypothetical protein; Provisional; Region: PRK08912
1064535001661	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535001662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535001663	homodimer interface [polypeptide binding]; other site
1064535001664	catalytic residue [active]
1064535001665	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1064535001666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1064535001667	ATP binding site [chemical binding]; other site
1064535001668	Mg2+ binding site [ion binding]; other site
1064535001669	G-X-G motif; other site
1064535001670	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1064535001671	anchoring element; other site
1064535001672	dimer interface [polypeptide binding]; other site
1064535001673	ATP binding site [chemical binding]; other site
1064535001674	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1064535001675	active site
1064535001676	putative metal-binding site [ion binding]; other site
1064535001677	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1064535001678	Protein of unknown function (DUF721); Region: DUF721; pfam05258
1064535001679	recombination protein F; Reviewed; Region: recF; PRK00064
1064535001680	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535001681	Walker A/P-loop; other site
1064535001682	ATP binding site [chemical binding]; other site
1064535001683	Q-loop/lid; other site
1064535001684	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535001685	ABC transporter signature motif; other site
1064535001686	Walker B; other site
1064535001687	D-loop; other site
1064535001688	H-loop/switch region; other site
1064535001689	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1064535001690	RNA binding surface [nucleotide binding]; other site
1064535001691	DNA polymerase III subunit beta; Validated; Region: PRK05643
1064535001692	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1064535001693	putative DNA binding surface [nucleotide binding]; other site
1064535001694	dimer interface [polypeptide binding]; other site
1064535001695	beta-clamp/clamp loader binding surface; other site
1064535001696	beta-clamp/translesion DNA polymerase binding surface; other site
1064535001697	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1064535001698	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1064535001699	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535001700	Walker A motif; other site
1064535001701	ATP binding site [chemical binding]; other site
1064535001702	Walker B motif; other site
1064535001703	arginine finger; other site
1064535001704	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1064535001705	DnaA box-binding interface [nucleotide binding]; other site
1064535001706	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1064535001707	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1064535001708	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1064535001709	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1064535001710	G-X-X-G motif; other site
1064535001711	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1064535001712	RxxxH motif; other site
1064535001713	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1064535001714	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1064535001715	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1064535001716	G1 box; other site
1064535001717	GTP/Mg2+ binding site [chemical binding]; other site
1064535001718	Switch I region; other site
1064535001719	G2 box; other site
1064535001720	Switch II region; other site
1064535001721	G3 box; other site
1064535001722	G4 box; other site
1064535001723	G5 box; other site
1064535001724	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1064535001725	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1064535001726	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1064535001727	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1064535001728	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1064535001729	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1064535001730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535001731	S-adenosylmethionine binding site [chemical binding]; other site
1064535001732	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1064535001733	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1064535001734	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1064535001735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535001736	putative substrate translocation pore; other site
1064535001737	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1064535001738	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1064535001739	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1064535001740	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1064535001741	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1064535001742	putative substrate binding site [chemical binding]; other site
1064535001743	putative ATP binding site [chemical binding]; other site
1064535001744	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1064535001745	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1064535001746	active site
1064535001747	phosphorylation site [posttranslational modification]
1064535001748	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1064535001749	active site
1064535001750	P-loop; other site
1064535001751	phosphorylation site [posttranslational modification]
1064535001752	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1064535001753	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1064535001754	dimerization domain swap beta strand [polypeptide binding]; other site
1064535001755	regulatory protein interface [polypeptide binding]; other site
1064535001756	active site
1064535001757	regulatory phosphorylation site [posttranslational modification]; other site
1064535001758	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1064535001759	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1064535001760	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1064535001761	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1064535001762	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1064535001763	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1064535001764	substrate binding pocket [chemical binding]; other site
1064535001765	membrane-bound complex binding site; other site
1064535001766	hinge residues; other site
1064535001767	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1064535001768	Na binding site [ion binding]; other site
1064535001769	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1064535001770	Protein of unknown function (DUF342); Region: DUF342; pfam03961
1064535001771	YadA-like C-terminal region; Region: YadA; pfam03895
1064535001772	S-layer homology domain; Region: SLH; pfam00395
1064535001773	LytTr DNA-binding domain; Region: LytTR; smart00850
1064535001774	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1064535001775	Sodium Bile acid symporter family; Region: SBF; pfam01758
1064535001776	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1064535001777	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1064535001778	active site
1064535001779	ATP-binding site [chemical binding]; other site
1064535001780	pantoate-binding site; other site
1064535001781	HXXH motif; other site
1064535001782	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1064535001783	active site
1064535001784	NTP binding site [chemical binding]; other site
1064535001785	metal binding triad [ion binding]; metal-binding site
1064535001786	antibiotic binding site [chemical binding]; other site
1064535001787	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552
1064535001788	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1064535001789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535001790	active site
1064535001791	phosphorylation site [posttranslational modification]
1064535001792	intermolecular recognition site; other site
1064535001793	dimerization interface [polypeptide binding]; other site
1064535001794	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1064535001795	DNA binding site [nucleotide binding]
1064535001796	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1064535001797	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1064535001798	dimerization interface [polypeptide binding]; other site
1064535001799	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1064535001800	dimer interface [polypeptide binding]; other site
1064535001801	phosphorylation site [posttranslational modification]
1064535001802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1064535001803	ATP binding site [chemical binding]; other site
1064535001804	Mg2+ binding site [ion binding]; other site
1064535001805	G-X-G motif; other site
1064535001806	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1064535001807	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1064535001808	metal-binding site [ion binding]
1064535001809	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1064535001810	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1064535001811	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1064535001812	metal-binding site [ion binding]
1064535001813	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1064535001814	metal-binding site [ion binding]
1064535001815	C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156
1064535001816	putative homodimer interface [polypeptide binding]; other site
1064535001817	putative homotetramer interface [polypeptide binding]; other site
1064535001818	putative allosteric switch controlling residues; other site
1064535001819	putative metal binding site [ion binding]; other site
1064535001820	putative homodimer-homodimer interface [polypeptide binding]; other site
1064535001821	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1064535001822	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
1064535001823	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1064535001824	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1064535001825	active site
1064535001826	FMN binding site [chemical binding]; other site
1064535001827	substrate binding site [chemical binding]; other site
1064535001828	putative catalytic residue [active]
1064535001829	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1064535001830	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1064535001831	GDP-binding site [chemical binding]; other site
1064535001832	ACT binding site; other site
1064535001833	IMP binding site; other site
1064535001834	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1064535001835	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1064535001836	ParB-like nuclease domain; Region: ParB; smart00470
1064535001837	KorB domain; Region: KorB; pfam08535
1064535001838	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1064535001839	Peptidase family M23; Region: Peptidase_M23; pfam01551
1064535001840	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1064535001841	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
1064535001842	putative ligand binding site [chemical binding]; other site
1064535001843	Protein of unknown function DUF45; Region: DUF45; pfam01863
1064535001844	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1064535001845	active site
1064535001846	catalytic site [active]
1064535001847	substrate binding site [chemical binding]; other site
1064535001848	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1064535001849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535001850	putative substrate translocation pore; other site
1064535001851	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1064535001852	MarR family; Region: MarR_2; pfam12802
1064535001853	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1064535001854	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161
1064535001855	putative ligand binding site [chemical binding]; other site
1064535001856	putative NAD binding site [chemical binding]; other site
1064535001857	catalytic site [active]
1064535001858	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535001859	Probable transposase; Region: OrfB_IS605; pfam01385
1064535001860	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535001861	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1064535001862	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1064535001863	DNA-binding site [nucleotide binding]; DNA binding site
1064535001864	FCD domain; Region: FCD; pfam07729
1064535001865	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1064535001866	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1064535001867	DNA binding site [nucleotide binding]
1064535001868	domain linker motif; other site
1064535001869	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1064535001870	dimerization interface [polypeptide binding]; other site
1064535001871	ligand binding site [chemical binding]; other site
1064535001872	Glucuronate isomerase; Region: UxaC; pfam02614
1064535001873	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1064535001874	altronate oxidoreductase; Provisional; Region: PRK03643
1064535001875	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1064535001876	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1064535001877	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1064535001878	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1064535001879	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1064535001880	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1064535001881	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535001882	putative substrate translocation pore; other site
1064535001883	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1064535001884	nucleotide binding site/active site [active]
1064535001885	HIT family signature motif; other site
1064535001886	catalytic residue [active]
1064535001887	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1064535001888	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1064535001889	substrate binding site [chemical binding]; other site
1064535001890	ATP binding site [chemical binding]; other site
1064535001891	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1064535001892	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1064535001893	active site
1064535001894	intersubunit interface [polypeptide binding]; other site
1064535001895	catalytic residue [active]
1064535001896	Rrf2 family protein; Region: rrf2_super; TIGR00738
1064535001897	Transcriptional regulator; Region: Rrf2; pfam02082
1064535001898	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1064535001899	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1064535001900	active site
1064535001901	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
1064535001902	Predicted membrane protein [Function unknown]; Region: COG1297
1064535001903	putative oligopeptide transporter, OPT family; Region: TIGR00733
1064535001904	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
1064535001905	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
1064535001906	metal binding site [ion binding]; metal-binding site
1064535001907	dimer interface [polypeptide binding]; other site
1064535001908	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1064535001909	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1064535001910	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1064535001911	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1064535001912	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1064535001913	active site
1064535001914	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
1064535001915	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
1064535001916	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1064535001917	dimerization interface [polypeptide binding]; other site
1064535001918	ATP binding site [chemical binding]; other site
1064535001919	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1064535001920	dimerization interface [polypeptide binding]; other site
1064535001921	ATP binding site [chemical binding]; other site
1064535001922	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1064535001923	putative active site [active]
1064535001924	catalytic triad [active]
1064535001925	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1064535001926	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1064535001927	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1064535001928	dimer interface [polypeptide binding]; other site
1064535001929	ssDNA binding site [nucleotide binding]; other site
1064535001930	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1064535001931	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1064535001932	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1064535001933	guanine deaminase; Region: guan_deamin; TIGR02967
1064535001934	active site
1064535001935	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1064535001936	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1064535001937	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1064535001938	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1064535001939	D-cysteine desulfhydrase; Validated; Region: PRK03910
1064535001940	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1064535001941	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1064535001942	catalytic residue [active]
1064535001943	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1064535001944	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1064535001945	xanthine permease; Region: pbuX; TIGR03173
1064535001946	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1064535001947	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1064535001948	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cd00133
1064535001949	active site
1064535001950	P-loop; other site
1064535001951	phosphorylation site [posttranslational modification]
1064535001952	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
1064535001953	Thioredoxin (TRX) superfamily; a large, diverse group of proteins containing a TRX-fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of...; Region: TRX_superfamily; cd01659
1064535001954	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1064535001955	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1064535001956	inhibitor-cofactor binding pocket; inhibition site
1064535001957	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535001958	catalytic residue [active]
1064535001959	AAA domain; Region: AAA_26; pfam13500
1064535001960	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1064535001961	BioY family; Region: BioY; pfam02632
1064535001962	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1064535001963	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1064535001964	homodimer interface [polypeptide binding]; other site
1064535001965	substrate-cofactor binding pocket; other site
1064535001966	catalytic residue [active]
1064535001967	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
1064535001968	Domain of unknown function DUF; Region: DUF204; pfam02659
1064535001969	Domain of unknown function DUF; Region: DUF204; pfam02659
1064535001970	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1064535001971	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1064535001972	active site
1064535001973	metal binding site [ion binding]; metal-binding site
1064535001974	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
1064535001975	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1064535001976	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1064535001977	Coenzyme A binding pocket [chemical binding]; other site
1064535001978	putative transposase OrfB; Reviewed; Region: PHA02517
1064535001979	HTH-like domain; Region: HTH_21; pfam13276
1064535001980	Integrase core domain; Region: rve; pfam00665
1064535001981	Integrase core domain; Region: rve_3; pfam13683
1064535001982	Transposase; Region: HTH_Tnp_1; cl17663
1064535001983	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1064535001984	EamA-like transporter family; Region: EamA; pfam00892
1064535001985	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535001986	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535001987	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1064535001988	dimerization interface [polypeptide binding]; other site
1064535001989	xanthine permease; Region: pbuX; TIGR03173
1064535001990	carbamate kinase; Reviewed; Region: PRK12686
1064535001991	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1064535001992	putative substrate binding site [chemical binding]; other site
1064535001993	nucleotide binding site [chemical binding]; other site
1064535001994	nucleotide binding site [chemical binding]; other site
1064535001995	homodimer interface [polypeptide binding]; other site
1064535001996	aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200
1064535001997	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1064535001998	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1064535001999	peptidase; Reviewed; Region: PRK13004
1064535002000	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
1064535002001	putative metal binding site [ion binding]; other site
1064535002002	putative dimer interface [polypeptide binding]; other site
1064535002003	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1064535002004	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
1064535002005	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1064535002006	catalytic residue [active]
1064535002007	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1064535002008	YheO-like PAS domain; Region: PAS_6; pfam08348
1064535002009	HTH domain; Region: HTH_22; pfam13309
1064535002010	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
1064535002011	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1064535002012	active site
1064535002013	putative selenate reductase subunit YgfK; Provisional; Region: PRK09853
1064535002014	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1064535002015	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1064535002016	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1064535002017	phenylhydantoinase; Validated; Region: PRK08323
1064535002018	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1064535002019	tetramer interface [polypeptide binding]; other site
1064535002020	active site
1064535002021	selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311
1064535002022	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1064535002023	catalytic loop [active]
1064535002024	iron binding site [ion binding]; other site
1064535002025	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1064535002026	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1064535002027	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1064535002028	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
1064535002029	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
1064535002030	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1064535002031	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1064535002032	dimer interface [polypeptide binding]; other site
1064535002033	putative functional site; other site
1064535002034	putative MPT binding site; other site
1064535002035	4Fe-4S binding domain; Region: Fer4; cl02805
1064535002036	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1064535002037	potential frameshift: common BLAST hit: gi|333997417|ref|YP_004530029.1| formate dehydrogenase subunit alpha
1064535002038	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1064535002039	molybdopterin cofactor binding site; other site
1064535002040	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1064535002041	molybdopterin cofactor binding site; other site
1064535002042	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1064535002043	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1064535002044	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1064535002045	GTP binding site; other site
1064535002046	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1064535002047	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
1064535002048	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
1064535002049	putative MPT binding site; other site
1064535002050	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1064535002051	trimer interface [polypeptide binding]; other site
1064535002052	dimer interface [polypeptide binding]; other site
1064535002053	putative active site [active]
1064535002054	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1064535002055	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535002056	FeS/SAM binding site; other site
1064535002057	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1064535002058	MOSC domain; Region: MOSC; pfam03473
1064535002059	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1064535002060	MPT binding site; other site
1064535002061	trimer interface [polypeptide binding]; other site
1064535002062	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1064535002063	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1064535002064	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1064535002065	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535002066	dimer interface [polypeptide binding]; other site
1064535002067	conserved gate region; other site
1064535002068	putative PBP binding loops; other site
1064535002069	ABC-ATPase subunit interface; other site
1064535002070	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1064535002071	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535002072	Walker A/P-loop; other site
1064535002073	ATP binding site [chemical binding]; other site
1064535002074	Q-loop/lid; other site
1064535002075	ABC transporter signature motif; other site
1064535002076	Walker B; other site
1064535002077	D-loop; other site
1064535002078	H-loop/switch region; other site
1064535002079	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1064535002080	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1064535002081	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
1064535002082	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1064535002083	Ligand binding site; other site
1064535002084	metal-binding site
1064535002085	amino acid transporter; Region: 2A0306; TIGR00909
1064535002086	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1064535002087	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1064535002088	Ligand Binding Site [chemical binding]; other site
1064535002089	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1064535002090	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1064535002091	active site
1064535002092	Zn binding site [ion binding]; other site
1064535002093	pyruvate kinase; Provisional; Region: PRK06354
1064535002094	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1064535002095	domain interfaces; other site
1064535002096	active site
1064535002097	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1064535002098	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
1064535002099	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
1064535002100	putative metal binding site [ion binding]; other site
1064535002101	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1064535002102	hybrid cluster protein; Provisional; Region: PRK05290
1064535002103	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1064535002104	ACS interaction site; other site
1064535002105	CODH interaction site; other site
1064535002106	metal cluster binding site [ion binding]; other site
1064535002107	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1064535002108	active site
1064535002109	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1064535002110	GIY-YIG motif/motif A; other site
1064535002111	putative active site [active]
1064535002112	putative metal binding site [ion binding]; other site
1064535002113	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1064535002114	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1064535002115	active site
1064535002116	oxyanion hole [active]
1064535002117	catalytic triad [active]
1064535002118	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1064535002119	MarR family; Region: MarR_2; pfam12802
1064535002120	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1064535002121	glycerol kinase; Provisional; Region: glpK; PRK00047
1064535002122	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1064535002123	N- and C-terminal domain interface [polypeptide binding]; other site
1064535002124	active site
1064535002125	MgATP binding site [chemical binding]; other site
1064535002126	catalytic site [active]
1064535002127	metal binding site [ion binding]; metal-binding site
1064535002128	glycerol binding site [chemical binding]; other site
1064535002129	homotetramer interface [polypeptide binding]; other site
1064535002130	homodimer interface [polypeptide binding]; other site
1064535002131	FBP binding site [chemical binding]; other site
1064535002132	protein IIAGlc interface [polypeptide binding]; other site
1064535002133	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1064535002134	amphipathic channel; other site
1064535002135	Asn-Pro-Ala signature motifs; other site
1064535002136	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1064535002137	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1064535002138	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1064535002139	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1064535002140	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1064535002141	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
1064535002142	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
1064535002143	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1064535002144	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1064535002145	dimer interface [polypeptide binding]; other site
1064535002146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535002147	catalytic residue [active]
1064535002148	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1064535002149	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1064535002150	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1064535002151	trimer interface [polypeptide binding]; other site
1064535002152	active site
1064535002153	substrate binding site [chemical binding]; other site
1064535002154	CoA binding site [chemical binding]; other site
1064535002155	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
1064535002156	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1064535002157	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1064535002158	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1064535002159	Cysteine-rich domain; Region: CCG; pfam02754
1064535002160	Cysteine-rich domain; Region: CCG; pfam02754
1064535002161	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1064535002162	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1064535002163	substrate binding pocket [chemical binding]; other site
1064535002164	chain length determination region; other site
1064535002165	substrate-Mg2+ binding site; other site
1064535002166	catalytic residues [active]
1064535002167	aspartate-rich region 1; other site
1064535002168	active site lid residues [active]
1064535002169	aspartate-rich region 2; other site
1064535002170	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
1064535002171	UbiA prenyltransferase family; Region: UbiA; pfam01040
1064535002172	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1064535002173	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535002174	S-adenosylmethionine binding site [chemical binding]; other site
1064535002175	oxidoreductase; Provisional; Region: PRK10015
1064535002176	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
1064535002177	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1064535002178	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1064535002179	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1064535002180	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1064535002181	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1064535002182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535002183	active site
1064535002184	phosphorylation site [posttranslational modification]
1064535002185	intermolecular recognition site; other site
1064535002186	dimerization interface [polypeptide binding]; other site
1064535002187	LytTr DNA-binding domain; Region: LytTR; smart00850
1064535002188	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1064535002189	FAD binding domain; Region: FAD_binding_4; pfam01565
1064535002190	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
1064535002191	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535002192	FeS/SAM binding site; other site
1064535002193	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1064535002194	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1064535002195	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1064535002196	putative valine binding site [chemical binding]; other site
1064535002197	dimer interface [polypeptide binding]; other site
1064535002198	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1064535002199	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
1064535002200	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1064535002201	PYR/PP interface [polypeptide binding]; other site
1064535002202	dimer interface [polypeptide binding]; other site
1064535002203	TPP binding site [chemical binding]; other site
1064535002204	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1064535002205	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1064535002206	TPP-binding site [chemical binding]; other site
1064535002207	dimer interface [polypeptide binding]; other site
1064535002208	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1064535002209	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1064535002210	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1064535002211	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1064535002212	Carbon starvation protein CstA; Region: CstA; pfam02554
1064535002213	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1064535002214	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1064535002215	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1064535002216	putative active site [active]
1064535002217	putative NTP binding site [chemical binding]; other site
1064535002218	putative nucleic acid binding site [nucleotide binding]; other site
1064535002219	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1064535002220	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1064535002221	Carbon starvation protein CstA; Region: CstA; pfam02554
1064535002222	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1064535002223	Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171
1064535002224	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1064535002225	putative active site [active]
1064535002226	metal binding site [ion binding]; metal-binding site
1064535002227	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1064535002228	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1064535002229	putative dimer interface [polypeptide binding]; other site
1064535002230	active site pocket [active]
1064535002231	putative cataytic base [active]
1064535002232	Protein of unknown function DUF111; Region: DUF111; pfam01969
1064535002233	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1064535002234	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1064535002235	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1064535002236	putative active site [active]
1064535002237	putative NTP binding site [chemical binding]; other site
1064535002238	putative nucleic acid binding site [nucleotide binding]; other site
1064535002239	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1064535002240	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1064535002241	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1064535002242	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1064535002243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535002244	active site
1064535002245	phosphorylation site [posttranslational modification]
1064535002246	intermolecular recognition site; other site
1064535002247	dimerization interface [polypeptide binding]; other site
1064535002248	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1064535002249	DNA binding site [nucleotide binding]
1064535002250	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1064535002251	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1064535002252	dimerization interface [polypeptide binding]; other site
1064535002253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1064535002254	dimer interface [polypeptide binding]; other site
1064535002255	phosphorylation site [posttranslational modification]
1064535002256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1064535002257	ATP binding site [chemical binding]; other site
1064535002258	Mg2+ binding site [ion binding]; other site
1064535002259	G-X-G motif; other site
1064535002260	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1064535002261	dimerization interface [polypeptide binding]; other site
1064535002262	putative ATP binding site [chemical binding]; other site
1064535002263	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535002264	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535002265	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1064535002266	dimerization interface [polypeptide binding]; other site
1064535002267	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1064535002268	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1064535002269	ligand binding site [chemical binding]; other site
1064535002270	NAD binding site [chemical binding]; other site
1064535002271	dimerization interface [polypeptide binding]; other site
1064535002272	catalytic site [active]
1064535002273	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1064535002274	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1064535002275	transmembrane helices; other site
1064535002276	putative metallo-dependent hydrolase; Provisional; Region: PRK12394
1064535002277	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1064535002278	active site
1064535002279	hypothetical protein; Validated; Region: PRK06201
1064535002280	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
1064535002281	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1064535002282	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1064535002283	ligand binding site [chemical binding]; other site
1064535002284	NAD binding site [chemical binding]; other site
1064535002285	dimerization interface [polypeptide binding]; other site
1064535002286	catalytic site [active]
1064535002287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535002288	D-galactonate transporter; Region: 2A0114; TIGR00893
1064535002289	putative substrate translocation pore; other site
1064535002290	adenylosuccinate lyase; Provisional; Region: PRK07492
1064535002291	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1064535002292	tetramer interface [polypeptide binding]; other site
1064535002293	active site
1064535002294	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1064535002295	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1064535002296	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1064535002297	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1064535002298	catalytic residue [active]
1064535002299	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1064535002300	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1064535002301	catalytic residues [active]
1064535002302	TSCPD domain; Region: TSCPD; cl14834
1064535002303	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
1064535002304	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
1064535002305	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
1064535002306	G1 box; other site
1064535002307	putative GEF interaction site [polypeptide binding]; other site
1064535002308	GTP/Mg2+ binding site [chemical binding]; other site
1064535002309	Switch I region; other site
1064535002310	G2 box; other site
1064535002311	G3 box; other site
1064535002312	Switch II region; other site
1064535002313	G4 box; other site
1064535002314	G5 box; other site
1064535002315	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
1064535002316	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
1064535002317	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
1064535002318	selenocysteine synthase; Provisional; Region: PRK04311
1064535002319	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
1064535002320	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
1064535002321	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1064535002322	catalytic residue [active]
1064535002323	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1064535002324	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1064535002325	DNA binding site [nucleotide binding]
1064535002326	domain linker motif; other site
1064535002327	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1064535002328	ligand binding site [chemical binding]; other site
1064535002329	dimerization interface [polypeptide binding]; other site
1064535002330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535002331	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
1064535002332	Probable transposase; Region: OrfB_IS605; pfam01385
1064535002333	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535002334	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1064535002335	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1064535002336	active site pocket [active]
1064535002337	putative dimer interface [polypeptide binding]; other site
1064535002338	putative cataytic base [active]
1064535002339	RelB antitoxin; Region: RelB; cl01171
1064535002340	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1064535002341	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1064535002342	active site
1064535002343	FMN binding site [chemical binding]; other site
1064535002344	substrate binding site [chemical binding]; other site
1064535002345	putative catalytic residue [active]
1064535002346	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
1064535002347	AAA domain; Region: AAA_14; pfam13173
1064535002348	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
1064535002349	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1064535002350	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
1064535002351	putative metal binding site [ion binding]; other site
1064535002352	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
1064535002353	EamA-like transporter family; Region: EamA; pfam00892
1064535002354	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1064535002355	EamA-like transporter family; Region: EamA; pfam00892
1064535002356	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1064535002357	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1064535002358	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1064535002359	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1064535002360	active site turn [active]
1064535002361	phosphorylation site [posttranslational modification]
1064535002362	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1064535002363	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1064535002364	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1064535002365	putative active site [active]
1064535002366	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1064535002367	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1064535002368	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1064535002369	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1064535002370	active site clefts [active]
1064535002371	zinc binding site [ion binding]; other site
1064535002372	dimer interface [polypeptide binding]; other site
1064535002373	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1064535002374	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1064535002375	dimer interface [polypeptide binding]; other site
1064535002376	active site
1064535002377	TPR repeat; Region: TPR_11; pfam13414
1064535002378	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1064535002379	binding surface
1064535002380	TPR motif; other site
1064535002381	TPR repeat; Region: TPR_11; pfam13414
1064535002382	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
1064535002383	trimer interface [polypeptide binding]; other site
1064535002384	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
1064535002385	Membrane transport protein; Region: Mem_trans; cl09117
1064535002386	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1064535002387	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
1064535002388	active site
1064535002389	catalytic site [active]
1064535002390	substrate binding site [chemical binding]; other site
1064535002391	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1064535002392	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1064535002393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535002394	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1064535002395	FAD binding domain; Region: FAD_binding_4; pfam01565
1064535002396	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1064535002397	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535002398	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1064535002399	putative substrate translocation pore; other site
1064535002400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535002401	putative substrate translocation pore; other site
1064535002402	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1064535002403	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1064535002404	metal binding site [ion binding]; metal-binding site
1064535002405	potential frameshift: common BLAST hit: gi|284047646|ref|YP_003397985.1| ABC transporter related protein
1064535002406	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1064535002407	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1064535002408	Walker A/P-loop; other site
1064535002409	ATP binding site [chemical binding]; other site
1064535002410	Q-loop/lid; other site
1064535002411	ABC transporter signature motif; other site
1064535002412	Walker B; other site
1064535002413	D-loop; other site
1064535002414	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535002415	H-loop/switch region; other site
1064535002416	NIL domain; Region: NIL; pfam09383
1064535002417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535002418	dimer interface [polypeptide binding]; other site
1064535002419	conserved gate region; other site
1064535002420	ABC-ATPase subunit interface; other site
1064535002421	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1064535002422	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1064535002423	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1064535002424	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535002425	motif II; other site
1064535002426	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1064535002427	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1064535002428	metal binding site [ion binding]; metal-binding site
1064535002429	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1064535002430	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535002431	Walker A/P-loop; other site
1064535002432	ATP binding site [chemical binding]; other site
1064535002433	Q-loop/lid; other site
1064535002434	ABC transporter signature motif; other site
1064535002435	Walker B; other site
1064535002436	D-loop; other site
1064535002437	H-loop/switch region; other site
1064535002438	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1064535002439	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1064535002440	ABC-ATPase subunit  interface; other site
1064535002441	dimer interface [polypeptide binding]; other site
1064535002442	putative PBP binding regions; other site
1064535002443	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1064535002444	metal binding site 2 [ion binding]; metal-binding site
1064535002445	putative DNA binding helix; other site
1064535002446	metal binding site 1 [ion binding]; metal-binding site
1064535002447	dimer interface [polypeptide binding]; other site
1064535002448	structural Zn2+ binding site [ion binding]; other site
1064535002449	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
1064535002450	FMN binding site [chemical binding]; other site
1064535002451	dimer interface [polypeptide binding]; other site
1064535002452	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1064535002453	dimerization interface [polypeptide binding]; other site
1064535002454	putative DNA binding site [nucleotide binding]; other site
1064535002455	putative Zn2+ binding site [ion binding]; other site
1064535002456	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1064535002457	catalytic core [active]
1064535002458	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1064535002459	dimer interface [polypeptide binding]; other site
1064535002460	substrate binding site [chemical binding]; other site
1064535002461	ATP binding site [chemical binding]; other site
1064535002462	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1064535002463	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1064535002464	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1064535002465	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
1064535002466	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1064535002467	DHH family; Region: DHH; pfam01368
1064535002468	DHHA1 domain; Region: DHHA1; pfam02272
1064535002469	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1064535002470	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1064535002471	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1064535002472	ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903
1064535002473	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535002474	Walker A motif; other site
1064535002475	ATP binding site [chemical binding]; other site
1064535002476	Walker B motif; other site
1064535002477	arginine finger; other site
1064535002478	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1064535002479	replicative DNA helicase; Region: DnaB; TIGR00665
1064535002480	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1064535002481	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1064535002482	Walker A motif; other site
1064535002483	ATP binding site [chemical binding]; other site
1064535002484	Walker B motif; other site
1064535002485	DNA binding loops [nucleotide binding]
1064535002486	elongation factor Tu; Reviewed; Region: PRK00049
1064535002487	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1064535002488	G1 box; other site
1064535002489	GEF interaction site [polypeptide binding]; other site
1064535002490	GTP/Mg2+ binding site [chemical binding]; other site
1064535002491	Switch I region; other site
1064535002492	G2 box; other site
1064535002493	G3 box; other site
1064535002494	Switch II region; other site
1064535002495	G4 box; other site
1064535002496	G5 box; other site
1064535002497	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1064535002498	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1064535002499	Antibiotic Binding Site [chemical binding]; other site
1064535002500	mechanosensitive channel MscS; Provisional; Region: PRK10334
1064535002501	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1064535002502	L-lactate permease; Region: Lactate_perm; cl00701
1064535002503	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1064535002504	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1064535002505	Coenzyme A transferase; Region: CoA_trans; smart00882
1064535002506	Coenzyme A transferase; Region: CoA_trans; cl17247
1064535002507	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
1064535002508	active site
1064535002509	metal binding site [ion binding]; metal-binding site
1064535002510	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1064535002511	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
1064535002512	active site
1064535002513	metal binding site [ion binding]; metal-binding site
1064535002514	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1064535002515	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
1064535002516	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
1064535002517	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
1064535002518	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
1064535002519	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1064535002520	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1064535002521	FAD binding site [chemical binding]; other site
1064535002522	homotetramer interface [polypeptide binding]; other site
1064535002523	substrate binding pocket [chemical binding]; other site
1064535002524	catalytic base [active]
1064535002525	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1064535002526	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1064535002527	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1064535002528	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1064535002529	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1064535002530	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1064535002531	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535002532	D-galactonate transporter; Region: 2A0114; TIGR00893
1064535002533	putative substrate translocation pore; other site
1064535002534	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1064535002535	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
1064535002536	putative dimer interface [polypeptide binding]; other site
1064535002537	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1064535002538	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
1064535002539	putative dimer interface [polypeptide binding]; other site
1064535002540	Cupin domain; Region: Cupin_2; pfam07883
1064535002541	metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921
1064535002542	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1064535002543	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535002544	Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624
1064535002545	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
1064535002546	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1064535002547	Fe-S cluster binding site [ion binding]; other site
1064535002548	active site
1064535002549	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1064535002550	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1064535002551	putative active site [active]
1064535002552	catalytic triad [active]
1064535002553	putative dimer interface [polypeptide binding]; other site
1064535002554	Membrane transport protein; Region: Mem_trans; cl09117
1064535002555	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1064535002556	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1064535002557	metal binding site [ion binding]; metal-binding site
1064535002558	glutamate dehydrogenase; Provisional; Region: PRK09414
1064535002559	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1064535002560	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1064535002561	NAD(P) binding site [chemical binding]; other site
1064535002562	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
1064535002563	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1064535002564	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
1064535002565	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
1064535002566	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1064535002567	active site
1064535002568	HIGH motif; other site
1064535002569	dimer interface [polypeptide binding]; other site
1064535002570	KMSKS motif; other site
1064535002571	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1064535002572	RNA binding surface [nucleotide binding]; other site
1064535002573	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1064535002574	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1064535002575	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1064535002576	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1064535002577	RPB1 interaction site [polypeptide binding]; other site
1064535002578	RPB10 interaction site [polypeptide binding]; other site
1064535002579	RPB11 interaction site [polypeptide binding]; other site
1064535002580	RPB3 interaction site [polypeptide binding]; other site
1064535002581	RPB12 interaction site [polypeptide binding]; other site
1064535002582	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1064535002583	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1064535002584	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1064535002585	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1064535002586	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1064535002587	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1064535002588	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1064535002589	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1064535002590	G-loop; other site
1064535002591	DNA binding site [nucleotide binding]
1064535002592	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1064535002593	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1064535002594	S17 interaction site [polypeptide binding]; other site
1064535002595	S8 interaction site; other site
1064535002596	16S rRNA interaction site [nucleotide binding]; other site
1064535002597	streptomycin interaction site [chemical binding]; other site
1064535002598	23S rRNA interaction site [nucleotide binding]; other site
1064535002599	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1064535002600	30S ribosomal protein S7; Validated; Region: PRK05302
1064535002601	elongation factor G; Reviewed; Region: PRK00007
1064535002602	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1064535002603	G1 box; other site
1064535002604	putative GEF interaction site [polypeptide binding]; other site
1064535002605	GTP/Mg2+ binding site [chemical binding]; other site
1064535002606	Switch I region; other site
1064535002607	G2 box; other site
1064535002608	G3 box; other site
1064535002609	Switch II region; other site
1064535002610	G4 box; other site
1064535002611	G5 box; other site
1064535002612	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1064535002613	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1064535002614	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1064535002615	elongation factor Tu; Reviewed; Region: PRK00049
1064535002616	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1064535002617	G1 box; other site
1064535002618	GEF interaction site [polypeptide binding]; other site
1064535002619	GTP/Mg2+ binding site [chemical binding]; other site
1064535002620	Switch I region; other site
1064535002621	G2 box; other site
1064535002622	G3 box; other site
1064535002623	Switch II region; other site
1064535002624	G4 box; other site
1064535002625	G5 box; other site
1064535002626	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1064535002627	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1064535002628	Antibiotic Binding Site [chemical binding]; other site
1064535002629	putative transposase OrfB; Reviewed; Region: PHA02517
1064535002630	HTH-like domain; Region: HTH_21; pfam13276
1064535002631	Integrase core domain; Region: rve; pfam00665
1064535002632	Integrase core domain; Region: rve_3; pfam13683
1064535002633	Transposase; Region: HTH_Tnp_1; cl17663
1064535002634	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1064535002635	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1064535002636	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1064535002637	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1064535002638	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1064535002639	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1064535002640	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1064535002641	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1064535002642	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1064535002643	putative translocon binding site; other site
1064535002644	protein-rRNA interface [nucleotide binding]; other site
1064535002645	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1064535002646	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1064535002647	G-X-X-G motif; other site
1064535002648	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1064535002649	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1064535002650	23S rRNA interface [nucleotide binding]; other site
1064535002651	5S rRNA interface [nucleotide binding]; other site
1064535002652	putative antibiotic binding site [chemical binding]; other site
1064535002653	L25 interface [polypeptide binding]; other site
1064535002654	L27 interface [polypeptide binding]; other site
1064535002655	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1064535002656	23S rRNA interface [nucleotide binding]; other site
1064535002657	putative translocon interaction site; other site
1064535002658	signal recognition particle (SRP54) interaction site; other site
1064535002659	L23 interface [polypeptide binding]; other site
1064535002660	trigger factor interaction site; other site
1064535002661	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1064535002662	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1064535002663	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1064535002664	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1064535002665	RNA binding site [nucleotide binding]; other site
1064535002666	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1064535002667	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1064535002668	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1064535002669	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1064535002670	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1064535002671	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1064535002672	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1064535002673	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1064535002674	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1064535002675	5S rRNA interface [nucleotide binding]; other site
1064535002676	L27 interface [polypeptide binding]; other site
1064535002677	23S rRNA interface [nucleotide binding]; other site
1064535002678	L5 interface [polypeptide binding]; other site
1064535002679	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1064535002680	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1064535002681	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1064535002682	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1064535002683	23S rRNA binding site [nucleotide binding]; other site
1064535002684	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1064535002685	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1064535002686	SecY translocase; Region: SecY; pfam00344
1064535002687	adenylate kinase; Reviewed; Region: adk; PRK00279
1064535002688	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1064535002689	AMP-binding site [chemical binding]; other site
1064535002690	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1064535002691	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1064535002692	active site
1064535002693	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
1064535002694	RNA binding site [nucleotide binding]; other site
1064535002695	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1064535002696	rRNA binding site [nucleotide binding]; other site
1064535002697	predicted 30S ribosome binding site; other site
1064535002698	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1064535002699	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1064535002700	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1064535002701	30S ribosomal protein S11; Validated; Region: PRK05309
1064535002702	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1064535002703	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1064535002704	alphaNTD homodimer interface [polypeptide binding]; other site
1064535002705	alphaNTD - beta interaction site [polypeptide binding]; other site
1064535002706	alphaNTD - beta' interaction site [polypeptide binding]; other site
1064535002707	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1064535002708	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1064535002709	putative transposase OrfB; Reviewed; Region: PHA02517
1064535002710	HTH-like domain; Region: HTH_21; pfam13276
1064535002711	Integrase core domain; Region: rve; pfam00665
1064535002712	Integrase core domain; Region: rve_3; pfam13683
1064535002713	Transposase; Region: HTH_Tnp_1; cl17663
1064535002714	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
1064535002715	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1064535002716	putative active site [active]
1064535002717	nucleotide binding site [chemical binding]; other site
1064535002718	nudix motif; other site
1064535002719	putative metal binding site [ion binding]; other site
1064535002720	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
1064535002721	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1064535002722	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1064535002723	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
1064535002724	SLBB domain; Region: SLBB; pfam10531
1064535002725	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1064535002726	Chain length determinant protein; Region: Wzz; pfam02706
1064535002727	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1064535002728	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1064535002729	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1064535002730	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1064535002731	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1064535002732	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1064535002733	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1064535002734	active site
1064535002735	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1064535002736	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1064535002737	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1064535002738	active site
1064535002739	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1064535002740	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1064535002741	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1064535002742	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1064535002743	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1064535002744	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1064535002745	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1064535002746	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1064535002747	putative active site [active]
1064535002748	putative NTP binding site [chemical binding]; other site
1064535002749	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1064535002750	putative nucleic acid binding site [nucleotide binding]; other site
1064535002751	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1064535002752	active site
1064535002753	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1064535002754	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1064535002755	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1064535002756	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1064535002757	Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600
1064535002758	AAA domain; Region: AAA_21; pfam13304
1064535002759	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1064535002760	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1064535002761	Divergent AAA domain; Region: AAA_4; pfam04326
1064535002762	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
1064535002763	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
1064535002764	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1064535002765	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1064535002766	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535002767	Walker A motif; other site
1064535002768	ATP binding site [chemical binding]; other site
1064535002769	Walker B motif; other site
1064535002770	arginine finger; other site
1064535002771	Helix-turn-helix domain; Region: HTH_38; pfam13936
1064535002772	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
1064535002773	active site
1064535002774	catalytic triad [active]
1064535002775	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1064535002776	transmembrane helices; other site
1064535002777	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
1064535002778	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
1064535002779	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1064535002780	Zn2+ binding site [ion binding]; other site
1064535002781	Mg2+ binding site [ion binding]; other site
1064535002782	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1064535002783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1064535002784	NAD(P) binding site [chemical binding]; other site
1064535002785	active site
1064535002786	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1064535002787	active site
1064535002788	dimer interface [polypeptide binding]; other site
1064535002789	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1064535002790	active site
1064535002791	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1064535002792	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1064535002793	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1064535002794	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1064535002795	dihydroorotase; Validated; Region: pyrC; PRK09357
1064535002796	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1064535002797	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1064535002798	active site
1064535002799	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1064535002800	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1064535002801	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1064535002802	catalytic site [active]
1064535002803	subunit interface [polypeptide binding]; other site
1064535002804	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1064535002805	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1064535002806	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1064535002807	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1064535002808	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1064535002809	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1064535002810	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1064535002811	IMP binding site; other site
1064535002812	dimer interface [polypeptide binding]; other site
1064535002813	interdomain contacts; other site
1064535002814	partial ornithine binding site; other site
1064535002815	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1064535002816	dimer interface [polypeptide binding]; other site
1064535002817	catalytic triad [active]
1064535002818	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
1064535002819	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1064535002820	DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603
1064535002821	active site pocket [active]
1064535002822	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1064535002823	feedback inhibition sensing region; other site
1064535002824	homohexameric interface [polypeptide binding]; other site
1064535002825	nucleotide binding site [chemical binding]; other site
1064535002826	N-acetyl-L-glutamate binding site [chemical binding]; other site
1064535002827	acetylornithine aminotransferase; Provisional; Region: PRK02627
1064535002828	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1064535002829	inhibitor-cofactor binding pocket; inhibition site
1064535002830	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535002831	catalytic residue [active]
1064535002832	Fic family protein [Function unknown]; Region: COG3177
1064535002833	Fic/DOC family; Region: Fic; pfam02661
1064535002834	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1064535002835	DNA binding residues [nucleotide binding]
1064535002836	ornithine decarboxylase; Provisional; Region: PRK13578
1064535002837	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1064535002838	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1064535002839	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1064535002840	catalytic residue [active]
1064535002841	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1064535002842	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1064535002843	FAD binding site [chemical binding]; other site
1064535002844	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1064535002845	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1064535002846	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535002847	Probable transposase; Region: OrfB_IS605; pfam01385
1064535002848	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535002849	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1064535002850	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1064535002851	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1064535002852	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1064535002853	Walker A/P-loop; other site
1064535002854	ATP binding site [chemical binding]; other site
1064535002855	Q-loop/lid; other site
1064535002856	ABC transporter signature motif; other site
1064535002857	Walker B; other site
1064535002858	D-loop; other site
1064535002859	H-loop/switch region; other site
1064535002860	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1064535002861	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1064535002862	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1064535002863	Walker A/P-loop; other site
1064535002864	ATP binding site [chemical binding]; other site
1064535002865	Q-loop/lid; other site
1064535002866	ABC transporter signature motif; other site
1064535002867	Walker B; other site
1064535002868	D-loop; other site
1064535002869	H-loop/switch region; other site
1064535002870	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1064535002871	active site
1064535002872	catalytic triad [active]
1064535002873	oxyanion hole [active]
1064535002874	D-galactonate transporter; Region: 2A0114; TIGR00893
1064535002875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535002876	putative substrate translocation pore; other site
1064535002877	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1064535002878	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1064535002879	putative active site [active]
1064535002880	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1064535002881	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1064535002882	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1064535002883	phosphoglyceromutase; Provisional; Region: PRK05434
1064535002884	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1064535002885	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1064535002886	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1064535002887	Phosphoglycerate kinase; Region: PGK; pfam00162
1064535002888	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1064535002889	substrate binding site [chemical binding]; other site
1064535002890	hinge regions; other site
1064535002891	ADP binding site [chemical binding]; other site
1064535002892	catalytic site [active]
1064535002893	triosephosphate isomerase; Provisional; Region: PRK14567
1064535002894	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1064535002895	substrate binding site [chemical binding]; other site
1064535002896	dimer interface [polypeptide binding]; other site
1064535002897	catalytic triad [active]
1064535002898	TM2 domain; Region: TM2; pfam05154
1064535002899	Archaeal ATPase; Region: Arch_ATPase; pfam01637
1064535002900	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535002901	Walker A motif; other site
1064535002902	ATP binding site [chemical binding]; other site
1064535002903	Walker B motif; other site
1064535002904	arginine finger; other site
1064535002905	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
1064535002906	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
1064535002907	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1064535002908	putative NAD(P) binding site [chemical binding]; other site
1064535002909	catalytic Zn binding site [ion binding]; other site
1064535002910	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1064535002911	active site
1064535002912	phosphorylation site [posttranslational modification]
1064535002913	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1064535002914	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1064535002915	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1064535002916	active site
1064535002917	P-loop; other site
1064535002918	phosphorylation site [posttranslational modification]
1064535002919	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1064535002920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535002921	active site
1064535002922	phosphorylation site [posttranslational modification]
1064535002923	intermolecular recognition site; other site
1064535002924	dimerization interface [polypeptide binding]; other site
1064535002925	LytTr DNA-binding domain; Region: LytTR; smart00850
1064535002926	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1064535002927	HTH domain; Region: HTH_11; pfam08279
1064535002928	PRD domain; Region: PRD; pfam00874
1064535002929	PRD domain; Region: PRD; pfam00874
1064535002930	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1064535002931	active site
1064535002932	P-loop; other site
1064535002933	phosphorylation site [posttranslational modification]
1064535002934	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1064535002935	active site
1064535002936	phosphorylation site [posttranslational modification]
1064535002937	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1064535002938	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1064535002939	Predicted transcriptional regulator [Transcription]; Region: COG1959
1064535002940	Transcriptional regulator; Region: Rrf2; pfam02082
1064535002941	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1064535002942	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1064535002943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1064535002944	YbbR-like protein; Region: YbbR; pfam07949
1064535002945	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1064535002946	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1064535002947	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1064535002948	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1064535002949	active site
1064535002950	substrate binding site [chemical binding]; other site
1064535002951	metal binding site [ion binding]; metal-binding site
1064535002952	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1064535002953	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1064535002954	glutaminase active site [active]
1064535002955	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1064535002956	dimer interface [polypeptide binding]; other site
1064535002957	active site
1064535002958	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1064535002959	dimer interface [polypeptide binding]; other site
1064535002960	active site
1064535002961	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1064535002962	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
1064535002963	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
1064535002964	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
1064535002965	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
1064535002966	Transposase; Region: HTH_Tnp_1; cl17663
1064535002967	putative transposase OrfB; Reviewed; Region: PHA02517
1064535002968	HTH-like domain; Region: HTH_21; pfam13276
1064535002969	Integrase core domain; Region: rve; pfam00665
1064535002970	Integrase core domain; Region: rve_3; pfam13683
1064535002971	HAMP domain; Region: HAMP; pfam00672
1064535002972	dimerization interface [polypeptide binding]; other site
1064535002973	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1064535002974	dimer interface [polypeptide binding]; other site
1064535002975	phosphorylation site [posttranslational modification]
1064535002976	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1064535002977	ATP binding site [chemical binding]; other site
1064535002978	Mg2+ binding site [ion binding]; other site
1064535002979	G-X-G motif; other site
1064535002980	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1064535002981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535002982	active site
1064535002983	phosphorylation site [posttranslational modification]
1064535002984	intermolecular recognition site; other site
1064535002985	dimerization interface [polypeptide binding]; other site
1064535002986	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1064535002987	DNA binding site [nucleotide binding]
1064535002988	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1064535002989	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1064535002990	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
1064535002991	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1064535002992	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1064535002993	RNA binding surface [nucleotide binding]; other site
1064535002994	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1064535002995	active site
1064535002996	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1064535002997	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1064535002998	active site
1064535002999	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1064535003000	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1064535003001	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1064535003002	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1064535003003	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1064535003004	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1064535003005	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1064535003006	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
1064535003007	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1064535003008	active site
1064535003009	dimer interface [polypeptide binding]; other site
1064535003010	effector binding site; other site
1064535003011	TSCPD domain; Region: TSCPD; pfam12637
1064535003012	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
1064535003013	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1064535003014	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1064535003015	catalytic residue [active]
1064535003016	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1064535003017	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1064535003018	ligand binding site [chemical binding]; other site
1064535003019	NAD binding site [chemical binding]; other site
1064535003020	dimerization interface [polypeptide binding]; other site
1064535003021	catalytic site [active]
1064535003022	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1064535003023	putative L-serine binding site [chemical binding]; other site
1064535003024	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1064535003025	catalytic core [active]
1064535003026	seryl-tRNA synthetase; Provisional; Region: PRK05431
1064535003027	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1064535003028	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1064535003029	dimer interface [polypeptide binding]; other site
1064535003030	active site
1064535003031	motif 1; other site
1064535003032	motif 2; other site
1064535003033	motif 3; other site
1064535003034	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1064535003035	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1064535003036	putative active site [active]
1064535003037	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1064535003038	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1064535003039	hinge; other site
1064535003040	active site
1064535003041	rod shape-determining protein MreB; Provisional; Region: PRK13930
1064535003042	MreB and similar proteins; Region: MreB_like; cd10225
1064535003043	nucleotide binding site [chemical binding]; other site
1064535003044	Mg binding site [ion binding]; other site
1064535003045	putative protofilament interaction site [polypeptide binding]; other site
1064535003046	RodZ interaction site [polypeptide binding]; other site
1064535003047	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
1064535003048	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1064535003049	Permease; Region: Permease; pfam02405
1064535003050	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1064535003051	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1064535003052	Walker A/P-loop; other site
1064535003053	ATP binding site [chemical binding]; other site
1064535003054	Q-loop/lid; other site
1064535003055	ABC transporter signature motif; other site
1064535003056	Walker B; other site
1064535003057	D-loop; other site
1064535003058	H-loop/switch region; other site
1064535003059	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1064535003060	mce related protein; Region: MCE; pfam02470
1064535003061	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1064535003062	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1064535003063	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1064535003064	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1064535003065	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1064535003066	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1064535003067	Family of unknown function (DUF490); Region: DUF490; pfam04357
1064535003068	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
1064535003069	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1064535003070	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
1064535003071	DNA binding residues [nucleotide binding]
1064535003072	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1064535003073	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1064535003074	Surface antigen; Region: Bac_surface_Ag; pfam01103
1064535003075	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1064535003076	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1064535003077	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1064535003078	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1064535003079	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1064535003080	trimer interface [polypeptide binding]; other site
1064535003081	active site
1064535003082	UDP-GlcNAc binding site [chemical binding]; other site
1064535003083	lipid binding site [chemical binding]; lipid-binding site
1064535003084	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1064535003085	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1064535003086	putative acyl-acceptor binding pocket; other site
1064535003087	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
1064535003088	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1064535003089	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1064535003090	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535003091	active site
1064535003092	motif I; other site
1064535003093	motif II; other site
1064535003094	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535003095	motif II; other site
1064535003096	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1064535003097	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1064535003098	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1064535003099	TPP-binding site [chemical binding]; other site
1064535003100	dimer interface [polypeptide binding]; other site
1064535003101	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1064535003102	PYR/PP interface [polypeptide binding]; other site
1064535003103	dimer interface [polypeptide binding]; other site
1064535003104	TPP binding site [chemical binding]; other site
1064535003105	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1064535003106	recombination factor protein RarA; Reviewed; Region: PRK13342
1064535003107	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535003108	Walker A motif; other site
1064535003109	ATP binding site [chemical binding]; other site
1064535003110	Walker B motif; other site
1064535003111	arginine finger; other site
1064535003112	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1064535003113	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1064535003114	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1064535003115	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1064535003116	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1064535003117	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535003118	non-specific DNA binding site [nucleotide binding]; other site
1064535003119	salt bridge; other site
1064535003120	sequence-specific DNA binding site [nucleotide binding]; other site
1064535003121	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
1064535003122	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
1064535003123	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
1064535003124	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1064535003125	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1064535003126	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1064535003127	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1064535003128	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535003129	FeS/SAM binding site; other site
1064535003130	competence damage-inducible protein A; Provisional; Region: PRK00549
1064535003131	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1064535003132	putative MPT binding site; other site
1064535003133	Competence-damaged protein; Region: CinA; pfam02464
1064535003134	recombinase A; Provisional; Region: recA; PRK09354
1064535003135	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1064535003136	hexamer interface [polypeptide binding]; other site
1064535003137	Walker A motif; other site
1064535003138	ATP binding site [chemical binding]; other site
1064535003139	Walker B motif; other site
1064535003140	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1064535003141	phosphodiesterase; Provisional; Region: PRK12704
1064535003142	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1064535003143	Zn2+ binding site [ion binding]; other site
1064535003144	Mg2+ binding site [ion binding]; other site
1064535003145	ScpA/B protein; Region: ScpA_ScpB; cl00598
1064535003146	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1064535003147	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1064535003148	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1064535003149	RNA binding surface [nucleotide binding]; other site
1064535003150	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1064535003151	active site
1064535003152	flavoprotein, HI0933 family; Region: TIGR00275
1064535003153	cytidylate kinase; Provisional; Region: cmk; PRK00023
1064535003154	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1064535003155	CMP-binding site; other site
1064535003156	The sites determining sugar specificity; other site
1064535003157	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1064535003158	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1064535003159	putative acyl-acceptor binding pocket; other site
1064535003160	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
1064535003161	LytB protein; Region: LYTB; cl00507
1064535003162	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1064535003163	RNA binding site [nucleotide binding]; other site
1064535003164	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1064535003165	RNA binding site [nucleotide binding]; other site
1064535003166	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1064535003167	RNA binding site [nucleotide binding]; other site
1064535003168	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1064535003169	RNA binding site [nucleotide binding]; other site
1064535003170	GTP-binding protein Der; Reviewed; Region: PRK00093
1064535003171	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1064535003172	G1 box; other site
1064535003173	GTP/Mg2+ binding site [chemical binding]; other site
1064535003174	Switch I region; other site
1064535003175	G2 box; other site
1064535003176	Switch II region; other site
1064535003177	G3 box; other site
1064535003178	G4 box; other site
1064535003179	G5 box; other site
1064535003180	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1064535003181	G1 box; other site
1064535003182	GTP/Mg2+ binding site [chemical binding]; other site
1064535003183	Switch I region; other site
1064535003184	G2 box; other site
1064535003185	G3 box; other site
1064535003186	Switch II region; other site
1064535003187	G4 box; other site
1064535003188	G5 box; other site
1064535003189	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1064535003190	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1064535003191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535003192	S-adenosylmethionine binding site [chemical binding]; other site
1064535003193	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1064535003194	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1064535003195	active site
1064535003196	(T/H)XGH motif; other site
1064535003197	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1064535003198	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
1064535003199	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1064535003200	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
1064535003201	AIR carboxylase; Region: AIRC; smart01001
1064535003202	Protein of unknown function DUF111; Region: DUF111; cl03398
1064535003203	Escherichia coli YdjC-like family of  proteins; Region: YdjC; cd10808
1064535003204	putative active site [active]
1064535003205	YdjC motif; other site
1064535003206	Mg binding site [ion binding]; other site
1064535003207	putative homodimer interface [polypeptide binding]; other site
1064535003208	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1064535003209	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1064535003210	NAD(P) binding site [chemical binding]; other site
1064535003211	active site
1064535003212	hypothetical protein; Provisional; Region: PRK04435
1064535003213	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
1064535003214	homoserine dehydrogenase; Provisional; Region: PRK06349
1064535003215	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1064535003216	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1064535003217	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1064535003218	homoserine kinase; Provisional; Region: PRK01212
1064535003219	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1064535003220	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1064535003221	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1064535003222	putative NADH binding site [chemical binding]; other site
1064535003223	putative active site [active]
1064535003224	nudix motif; other site
1064535003225	putative metal binding site [ion binding]; other site
1064535003226	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1064535003227	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1064535003228	HIGH motif; other site
1064535003229	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1064535003230	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1064535003231	active site
1064535003232	KMSKS motif; other site
1064535003233	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1064535003234	tRNA binding surface [nucleotide binding]; other site
1064535003235	anticodon binding site; other site
1064535003236	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1064535003237	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1064535003238	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1064535003239	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1064535003240	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1064535003241	O-Antigen ligase; Region: Wzy_C; cl04850
1064535003242	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1064535003243	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1064535003244	CoA binding domain; Region: CoA_binding; pfam02629
1064535003245	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1064535003246	synthetase active site [active]
1064535003247	NTP binding site [chemical binding]; other site
1064535003248	metal binding site [ion binding]; metal-binding site
1064535003249	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1064535003250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535003251	active site
1064535003252	phosphorylation site [posttranslational modification]
1064535003253	intermolecular recognition site; other site
1064535003254	dimerization interface [polypeptide binding]; other site
1064535003255	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1064535003256	DNA binding site [nucleotide binding]
1064535003257	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1064535003258	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1064535003259	dimer interface [polypeptide binding]; other site
1064535003260	phosphorylation site [posttranslational modification]
1064535003261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1064535003262	ATP binding site [chemical binding]; other site
1064535003263	Mg2+ binding site [ion binding]; other site
1064535003264	G-X-G motif; other site
1064535003265	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1064535003266	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1064535003267	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
1064535003268	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1064535003269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535003270	S-adenosylmethionine binding site [chemical binding]; other site
1064535003271	DNA methylase; Region: N6_N4_Mtase; cl17433
1064535003272	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
1064535003273	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1064535003274	DNA methylase; Region: N6_N4_Mtase; pfam01555
1064535003275	DpnII restriction endonuclease; Region: DpnII; pfam04556
1064535003276	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
1064535003277	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1064535003278	active site
1064535003279	PHP Thumb interface [polypeptide binding]; other site
1064535003280	metal binding site [ion binding]; metal-binding site
1064535003281	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1064535003282	generic binding surface I; other site
1064535003283	generic binding surface II; other site
1064535003284	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1064535003285	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1064535003286	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1064535003287	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535003288	motif II; other site
1064535003289	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1064535003290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535003291	putative substrate translocation pore; other site
1064535003292	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1064535003293	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1064535003294	metal binding site [ion binding]; metal-binding site
1064535003295	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
1064535003296	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1064535003297	active site
1064535003298	NTP binding site [chemical binding]; other site
1064535003299	metal binding triad [ion binding]; metal-binding site
1064535003300	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1064535003301	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1064535003302	Zn2+ binding site [ion binding]; other site
1064535003303	Mg2+ binding site [ion binding]; other site
1064535003304	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
1064535003305	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1064535003306	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1064535003307	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1064535003308	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
1064535003309	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1064535003310	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1064535003311	homodimer interface [polypeptide binding]; other site
1064535003312	NADP binding site [chemical binding]; other site
1064535003313	substrate binding site [chemical binding]; other site
1064535003314	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1064535003315	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535003316	S-adenosylmethionine binding site [chemical binding]; other site
1064535003317	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1064535003318	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1064535003319	dimer interface [polypeptide binding]; other site
1064535003320	PYR/PP interface [polypeptide binding]; other site
1064535003321	TPP binding site [chemical binding]; other site
1064535003322	substrate binding site [chemical binding]; other site
1064535003323	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1064535003324	Domain of unknown function; Region: EKR; pfam10371
1064535003325	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1064535003326	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1064535003327	TPP-binding site [chemical binding]; other site
1064535003328	dimer interface [polypeptide binding]; other site
1064535003329	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
1064535003330	putative active site [active]
1064535003331	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1064535003332	catalytic core [active]
1064535003333	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1064535003334	potential frameshift: common BLAST hit: gi|161507042|ref|YP_001576996.1| transposase
1064535003335	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535003336	Probable transposase; Region: OrfB_IS605; pfam01385
1064535003337	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535003338	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
1064535003339	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1064535003340	dimer interface [polypeptide binding]; other site
1064535003341	FMN binding site [chemical binding]; other site
1064535003342	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1064535003343	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1064535003344	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1064535003345	RNA binding surface [nucleotide binding]; other site
1064535003346	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1064535003347	active site
1064535003348	catalytic site [active]
1064535003349	substrate binding site [chemical binding]; other site
1064535003350	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1064535003351	MPT binding site; other site
1064535003352	trimer interface [polypeptide binding]; other site
1064535003353	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1064535003354	homotrimer interface [polypeptide binding]; other site
1064535003355	Walker A motif; other site
1064535003356	GTP binding site [chemical binding]; other site
1064535003357	Walker B motif; other site
1064535003358	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1064535003359	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1064535003360	catalytic core [active]
1064535003361	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1064535003362	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1064535003363	RNA binding surface [nucleotide binding]; other site
1064535003364	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1064535003365	active site
1064535003366	uracil binding [chemical binding]; other site
1064535003367	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1064535003368	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1064535003369	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1064535003370	active site
1064535003371	elongation factor P; Validated; Region: PRK00529
1064535003372	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1064535003373	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1064535003374	RNA binding site [nucleotide binding]; other site
1064535003375	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1064535003376	RNA binding site [nucleotide binding]; other site
1064535003377	Asp23 family; Region: Asp23; pfam03780
1064535003378	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1064535003379	putative RNA binding site [nucleotide binding]; other site
1064535003380	UGMP family protein; Validated; Region: PRK09604
1064535003381	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1064535003382	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1064535003383	generic binding surface I; other site
1064535003384	generic binding surface II; other site
1064535003385	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1064535003386	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1064535003387	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1064535003388	substrate binding pocket [chemical binding]; other site
1064535003389	chain length determination region; other site
1064535003390	substrate-Mg2+ binding site; other site
1064535003391	catalytic residues [active]
1064535003392	aspartate-rich region 1; other site
1064535003393	active site lid residues [active]
1064535003394	aspartate-rich region 2; other site
1064535003395	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1064535003396	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1064535003397	RNA binding surface [nucleotide binding]; other site
1064535003398	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1064535003399	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
1064535003400	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
1064535003401	MraW methylase family; Region: Methyltransf_5; cl17771
1064535003402	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1064535003403	arginine repressor; Provisional; Region: PRK04280
1064535003404	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1064535003405	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1064535003406	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1064535003407	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1064535003408	Walker A/P-loop; other site
1064535003409	ATP binding site [chemical binding]; other site
1064535003410	Q-loop/lid; other site
1064535003411	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1064535003412	ABC transporter signature motif; other site
1064535003413	Walker B; other site
1064535003414	D-loop; other site
1064535003415	H-loop/switch region; other site
1064535003416	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1064535003417	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1064535003418	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1064535003419	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1064535003420	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1064535003421	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1064535003422	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1064535003423	dimer interface [polypeptide binding]; other site
1064535003424	active site
1064535003425	catalytic residue [active]
1064535003426	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1064535003427	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1064535003428	ATP binding site [chemical binding]; other site
1064535003429	Mg++ binding site [ion binding]; other site
1064535003430	motif III; other site
1064535003431	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1064535003432	nucleotide binding region [chemical binding]; other site
1064535003433	ATP-binding site [chemical binding]; other site
1064535003434	putrescine transporter; Provisional; Region: potE; PRK10655
1064535003435	Protein of unknown function (DUF423); Region: DUF423; cl01008
1064535003436	putative acyltransferase; Provisional; Region: PRK05790
1064535003437	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1064535003438	dimer interface [polypeptide binding]; other site
1064535003439	active site
1064535003440	putative acyltransferase; Provisional; Region: PRK05790
1064535003441	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1064535003442	dimer interface [polypeptide binding]; other site
1064535003443	active site
1064535003444	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
1064535003445	translation initiation factor IF-3; Region: infC; TIGR00168
1064535003446	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1064535003447	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1064535003448	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1064535003449	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1064535003450	23S rRNA binding site [nucleotide binding]; other site
1064535003451	L21 binding site [polypeptide binding]; other site
1064535003452	L13 binding site [polypeptide binding]; other site
1064535003453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535003454	putative substrate translocation pore; other site
1064535003455	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1064535003456	aspartate aminotransferase; Provisional; Region: PRK06836
1064535003457	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535003458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535003459	homodimer interface [polypeptide binding]; other site
1064535003460	catalytic residue [active]
1064535003461	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1064535003462	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1064535003463	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1064535003464	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1064535003465	protein binding site [polypeptide binding]; other site
1064535003466	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1064535003467	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
1064535003468	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
1064535003469	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1064535003470	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1064535003471	putative [4Fe-4S] binding site [ion binding]; other site
1064535003472	putative molybdopterin cofactor binding site [chemical binding]; other site
1064535003473	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1064535003474	molybdopterin cofactor binding site; other site
1064535003475	putative DNA-binding protein; Validated; Region: PRK00118
1064535003476	signal recognition particle protein; Provisional; Region: PRK10867
1064535003477	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1064535003478	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1064535003479	P loop; other site
1064535003480	GTP binding site [chemical binding]; other site
1064535003481	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1064535003482	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
1064535003483	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1064535003484	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
1064535003485	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
1064535003486	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1064535003487	RimM N-terminal domain; Region: RimM; pfam01782
1064535003488	PRC-barrel domain; Region: PRC; pfam05239
1064535003489	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1064535003490	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
1064535003491	hypothetical protein; Validated; Region: PRK00110
1064535003492	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
1064535003493	Hemerythrin-like domain; Region: Hr-like; cd12108
1064535003494	Fe binding site [ion binding]; other site
1064535003495	Sel1 repeat; Region: Sel1; cl02723
1064535003496	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1064535003497	Sel1-like repeats; Region: SEL1; smart00671
1064535003498	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1064535003499	G1 box; other site
1064535003500	GTP/Mg2+ binding site [chemical binding]; other site
1064535003501	G2 box; other site
1064535003502	Switch I region; other site
1064535003503	G3 box; other site
1064535003504	Switch II region; other site
1064535003505	G4 box; other site
1064535003506	G5 box; other site
1064535003507	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1064535003508	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535003509	FeS/SAM binding site; other site
1064535003510	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1064535003511	acyl carrier protein; Provisional; Region: acpP; PRK00982
1064535003512	EcsC protein family; Region: EcsC; pfam12787
1064535003513	Predicted transcriptional regulator [Transcription]; Region: COG2378
1064535003514	WYL domain; Region: WYL; pfam13280
1064535003515	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
1064535003516	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
1064535003517	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
1064535003518	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1064535003519	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1064535003520	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
1064535003521	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1064535003522	carboxyltransferase (CT) interaction site; other site
1064535003523	biotinylation site [posttranslational modification]; other site
1064535003524	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1064535003525	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1064535003526	Int/Topo IB signature motif; other site
1064535003527	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
1064535003528	BRO family, N-terminal domain; Region: Bro-N; pfam02498
1064535003529	Pleckstrin homology-like domain; Region: PH-like; cl17171
1064535003530	Short C-terminal domain; Region: SHOCT; pfam09851
1064535003531	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
1064535003532	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
1064535003533	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1064535003534	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535003535	non-specific DNA binding site [nucleotide binding]; other site
1064535003536	salt bridge; other site
1064535003537	sequence-specific DNA binding site [nucleotide binding]; other site
1064535003538	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1064535003539	Catalytic site [active]
1064535003540	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535003541	non-specific DNA binding site [nucleotide binding]; other site
1064535003542	salt bridge; other site
1064535003543	sequence-specific DNA binding site [nucleotide binding]; other site
1064535003544	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
1064535003545	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
1064535003546	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1064535003547	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1064535003548	P-loop; other site
1064535003549	Magnesium ion binding site [ion binding]; other site
1064535003550	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1064535003551	Magnesium ion binding site [ion binding]; other site
1064535003552	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1064535003553	ParB-like nuclease domain; Region: ParBc; pfam02195
1064535003554	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
1064535003555	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
1064535003556	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
1064535003557	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1064535003558	oligomer interface [polypeptide binding]; other site
1064535003559	active site residues [active]
1064535003560	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
1064535003561	Dolichol-phosphate mannosyltransferase subunit 3 (DPM3); Region: DPM3; pfam08285
1064535003562	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
1064535003563	Phage tail tube protein FII; Region: Phage_tube; cl01390
1064535003564	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1064535003565	Phage Tail Protein X; Region: Phage_tail_X; cl02088
1064535003566	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
1064535003567	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
1064535003568	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
1064535003569	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
1064535003570	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
1064535003571	Baseplate J-like protein; Region: Baseplate_J; pfam04865
1064535003572	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
1064535003573	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1064535003574	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1064535003575	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1064535003576	putative active site [active]
1064535003577	putative NTP binding site [chemical binding]; other site
1064535003578	putative nucleic acid binding site [nucleotide binding]; other site
1064535003579	Holin family; Region: Phage_holin_4; pfam05105
1064535003580	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1064535003581	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1064535003582	active site
1064535003583	metal binding site [ion binding]; metal-binding site
1064535003584	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1064535003585	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1064535003586	interface (dimer of trimers) [polypeptide binding]; other site
1064535003587	Substrate-binding/catalytic site; other site
1064535003588	Zn-binding sites [ion binding]; other site
1064535003589	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1064535003590	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1064535003591	active site
1064535003592	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1064535003593	Asp23 family; Region: Asp23; pfam03780
1064535003594	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1064535003595	Coenzyme A transferase; Region: CoA_trans; smart00882
1064535003596	Coenzyme A transferase; Region: CoA_trans; cl17247
1064535003597	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1064535003598	subunit interaction site [polypeptide binding]; other site
1064535003599	PHB binding site; other site
1064535003600	CoenzymeA binding site [chemical binding]; other site
1064535003601	acetolactate synthase; Reviewed; Region: PRK08322
1064535003602	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1064535003603	PYR/PP interface [polypeptide binding]; other site
1064535003604	dimer interface [polypeptide binding]; other site
1064535003605	TPP binding site [chemical binding]; other site
1064535003606	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1064535003607	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1064535003608	TPP-binding site [chemical binding]; other site
1064535003609	dimer interface [polypeptide binding]; other site
1064535003610	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1064535003611	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1064535003612	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1064535003613	Catalytic site [active]
1064535003614	QueT transporter; Region: QueT; pfam06177
1064535003615	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1064535003616	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1064535003617	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
1064535003618	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1064535003619	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1064535003620	active site
1064535003621	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1064535003622	homooctamer interface [polypeptide binding]; other site
1064535003623	active site
1064535003624	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1064535003625	catalytic center binding site [active]
1064535003626	ATP binding site [chemical binding]; other site
1064535003627	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1064535003628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535003629	active site
1064535003630	phosphorylation site [posttranslational modification]
1064535003631	intermolecular recognition site; other site
1064535003632	dimerization interface [polypeptide binding]; other site
1064535003633	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1064535003634	DNA binding site [nucleotide binding]
1064535003635	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1064535003636	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1064535003637	dimerization interface [polypeptide binding]; other site
1064535003638	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1064535003639	dimer interface [polypeptide binding]; other site
1064535003640	phosphorylation site [posttranslational modification]
1064535003641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1064535003642	ATP binding site [chemical binding]; other site
1064535003643	Mg2+ binding site [ion binding]; other site
1064535003644	G-X-G motif; other site
1064535003645	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1064535003646	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1064535003647	active site
1064535003648	metal binding site [ion binding]; metal-binding site
1064535003649	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1064535003650	nucleotide binding site/active site [active]
1064535003651	HIT family signature motif; other site
1064535003652	catalytic residue [active]
1064535003653	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1064535003654	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1064535003655	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1064535003656	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
1064535003657	active site
1064535003658	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1064535003659	active site
1064535003660	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
1064535003661	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535003662	FeS/SAM binding site; other site
1064535003663	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1064535003664	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1064535003665	active site
1064535003666	catalytic site [active]
1064535003667	substrate binding site [chemical binding]; other site
1064535003668	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1064535003669	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1064535003670	NAD(P) binding site [chemical binding]; other site
1064535003671	catalytic residues [active]
1064535003672	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1064535003673	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535003674	motif II; other site
1064535003675	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
1064535003676	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1064535003677	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1064535003678	Peptidase M16C associated; Region: M16C_assoc; pfam08367
1064535003679	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1064535003680	active site
1064535003681	HIGH motif; other site
1064535003682	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1064535003683	active site
1064535003684	KMSKS motif; other site
1064535003685	cell division protein MraZ; Reviewed; Region: PRK00326
1064535003686	MraZ protein; Region: MraZ; pfam02381
1064535003687	MraZ protein; Region: MraZ; pfam02381
1064535003688	MraW methylase family; Region: Methyltransf_5; pfam01795
1064535003689	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1064535003690	Cell division protein FtsL; Region: FtsL; cl11433
1064535003691	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1064535003692	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1064535003693	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1064535003694	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1064535003695	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1064535003696	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1064535003697	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1064535003698	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1064535003699	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1064535003700	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1064535003701	Mg++ binding site [ion binding]; other site
1064535003702	putative catalytic motif [active]
1064535003703	putative substrate binding site [chemical binding]; other site
1064535003704	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
1064535003705	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1064535003706	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1064535003707	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1064535003708	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1064535003709	active site
1064535003710	homodimer interface [polypeptide binding]; other site
1064535003711	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1064535003712	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1064535003713	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1064535003714	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1064535003715	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1064535003716	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1064535003717	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1064535003718	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1064535003719	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1064535003720	cell division protein FtsZ; Validated; Region: PRK09330
1064535003721	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1064535003722	nucleotide binding site [chemical binding]; other site
1064535003723	SulA interaction site; other site
1064535003724	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1064535003725	ATP cone domain; Region: ATP-cone; pfam03477
1064535003726	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
1064535003727	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1064535003728	putative ribose interaction site [chemical binding]; other site
1064535003729	putative ADP binding site [chemical binding]; other site
1064535003730	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1064535003731	active site
1064535003732	nucleotide binding site [chemical binding]; other site
1064535003733	HIGH motif; other site
1064535003734	KMSKS motif; other site
1064535003735	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
1064535003736	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
1064535003737	NADP binding site [chemical binding]; other site
1064535003738	homopentamer interface [polypeptide binding]; other site
1064535003739	substrate binding site [chemical binding]; other site
1064535003740	active site
1064535003741	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
1064535003742	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535003743	active site
1064535003744	motif I; other site
1064535003745	motif II; other site
1064535003746	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1064535003747	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1064535003748	putative active site [active]
1064535003749	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1064535003750	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1064535003751	putative active site [active]
1064535003752	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1064535003753	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1064535003754	CoenzymeA binding site [chemical binding]; other site
1064535003755	subunit interaction site [polypeptide binding]; other site
1064535003756	PHB binding site; other site
1064535003757	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1064535003758	CoenzymeA binding site [chemical binding]; other site
1064535003759	subunit interaction site [polypeptide binding]; other site
1064535003760	PHB binding site; other site
1064535003761	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1064535003762	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1064535003763	active site
1064535003764	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1064535003765	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1064535003766	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1064535003767	dimer interface [polypeptide binding]; other site
1064535003768	motif 1; other site
1064535003769	active site
1064535003770	motif 2; other site
1064535003771	motif 3; other site
1064535003772	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1064535003773	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1064535003774	putative tRNA-binding site [nucleotide binding]; other site
1064535003775	B3/4 domain; Region: B3_4; pfam03483
1064535003776	tRNA synthetase B5 domain; Region: B5; smart00874
1064535003777	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1064535003778	dimer interface [polypeptide binding]; other site
1064535003779	motif 1; other site
1064535003780	motif 3; other site
1064535003781	motif 2; other site
1064535003782	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1064535003783	trigger factor; Provisional; Region: tig; PRK01490
1064535003784	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1064535003785	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1064535003786	Clp protease; Region: CLP_protease; pfam00574
1064535003787	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1064535003788	oligomer interface [polypeptide binding]; other site
1064535003789	active site residues [active]
1064535003790	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1064535003791	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1064535003792	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535003793	Walker A motif; other site
1064535003794	ATP binding site [chemical binding]; other site
1064535003795	Walker B motif; other site
1064535003796	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1064535003797	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1064535003798	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1064535003799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535003800	Walker A motif; other site
1064535003801	ATP binding site [chemical binding]; other site
1064535003802	Walker B motif; other site
1064535003803	arginine finger; other site
1064535003804	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1064535003805	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1064535003806	G1 box; other site
1064535003807	GTP/Mg2+ binding site [chemical binding]; other site
1064535003808	Switch I region; other site
1064535003809	G2 box; other site
1064535003810	G3 box; other site
1064535003811	Switch II region; other site
1064535003812	G4 box; other site
1064535003813	G5 box; other site
1064535003814	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1064535003815	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1064535003816	catalytic residues [active]
1064535003817	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1064535003818	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1064535003819	Ligand binding site; other site
1064535003820	Putative Catalytic site; other site
1064535003821	DXD motif; other site
1064535003822	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1064535003823	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1064535003824	NlpC/P60 family; Region: NLPC_P60; pfam00877
1064535003825	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1064535003826	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1064535003827	motif 1; other site
1064535003828	active site
1064535003829	motif 2; other site
1064535003830	motif 3; other site
1064535003831	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1064535003832	hypothetical protein; Provisional; Region: PRK05473
1064535003833	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1064535003834	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1064535003835	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535003836	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535003837	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1064535003838	dimerization interface [polypeptide binding]; other site
1064535003839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535003840	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1064535003841	putative substrate translocation pore; other site
1064535003842	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1064535003843	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1064535003844	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1064535003845	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1064535003846	DNA binding residues [nucleotide binding]
1064535003847	putative dimer interface [polypeptide binding]; other site
1064535003848	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1064535003849	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1064535003850	putative active site [active]
1064535003851	putative NTP binding site [chemical binding]; other site
1064535003852	putative nucleic acid binding site [nucleotide binding]; other site
1064535003853	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1064535003854	serine/threonine transporter SstT; Provisional; Region: PRK13628
1064535003855	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1064535003856	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
1064535003857	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1064535003858	Interdomain contacts; other site
1064535003859	Cytokine receptor motif; other site
1064535003860	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1064535003861	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1064535003862	active site
1064535003863	metal binding site [ion binding]; metal-binding site
1064535003864	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1064535003865	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1064535003866	active site
1064535003867	HIGH motif; other site
1064535003868	dimer interface [polypeptide binding]; other site
1064535003869	KMSKS motif; other site
1064535003870	acetylornithine aminotransferase; Provisional; Region: PRK02627
1064535003871	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1064535003872	inhibitor-cofactor binding pocket; inhibition site
1064535003873	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535003874	catalytic residue [active]
1064535003875	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
1064535003876	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1064535003877	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1064535003878	active site
1064535003879	NAD binding site [chemical binding]; other site
1064535003880	metal binding site [ion binding]; metal-binding site
1064535003881	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1064535003882	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
1064535003883	active site residues [active]
1064535003884	dimer interface [polypeptide binding]; other site
1064535003885	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
1064535003886	hypothetical protein; Provisional; Region: PRK13665
1064535003887	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1064535003888	amino acid transporter; Region: 2A0306; TIGR00909
1064535003889	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1064535003890	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1064535003891	active site
1064535003892	homotetramer interface [polypeptide binding]; other site
1064535003893	homodimer interface [polypeptide binding]; other site
1064535003894	S-layer homology domain; Region: SLH; pfam00395
1064535003895	S-layer homology domain; Region: SLH; pfam00395
1064535003896	S-layer homology domain; Region: SLH; pfam00395
1064535003897	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1064535003898	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535003899	motif II; other site
1064535003900	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1064535003901	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1064535003902	active site
1064535003903	tetramer interface; other site
1064535003904	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
1064535003905	putative transposase OrfB; Reviewed; Region: PHA02517
1064535003906	HTH-like domain; Region: HTH_21; pfam13276
1064535003907	Integrase core domain; Region: rve; pfam00665
1064535003908	Integrase core domain; Region: rve_3; pfam13683
1064535003909	Transposase; Region: HTH_Tnp_1; cl17663
1064535003910	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
1064535003911	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1064535003912	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
1064535003913	active site
1064535003914	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1064535003915	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1064535003916	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535003917	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535003918	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1064535003919	dimerization interface [polypeptide binding]; other site
1064535003920	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1064535003921	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1064535003922	dimer interface [polypeptide binding]; other site
1064535003923	active site
1064535003924	metal binding site [ion binding]; metal-binding site
1064535003925	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535003926	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1064535003927	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1064535003928	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535003929	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1064535003930	eRF1 domain 2; Region: eRF1_2; pfam03464
1064535003931	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1064535003932	active site
1064535003933	substrate binding site [chemical binding]; other site
1064535003934	trimer interface [polypeptide binding]; other site
1064535003935	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1064535003936	CoA binding site [chemical binding]; other site
1064535003937	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535003938	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535003939	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1064535003940	dimerization interface [polypeptide binding]; other site
1064535003941	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535003942	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1064535003943	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1064535003944	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1064535003945	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1064535003946	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
1064535003947	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
1064535003948	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
1064535003949	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1064535003950	active site
1064535003951	putative DNA-binding cleft [nucleotide binding]; other site
1064535003952	dimer interface [polypeptide binding]; other site
1064535003953	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1064535003954	RuvA N terminal domain; Region: RuvA_N; pfam01330
1064535003955	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1064535003956	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1064535003957	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535003958	Walker A motif; other site
1064535003959	ATP binding site [chemical binding]; other site
1064535003960	Walker B motif; other site
1064535003961	arginine finger; other site
1064535003962	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1064535003963	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
1064535003964	Stage II sporulation protein; Region: SpoIID; pfam08486
1064535003965	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
1064535003966	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1064535003967	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1064535003968	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1064535003969	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1064535003970	Preprotein translocase subunit; Region: YajC; pfam02699
1064535003971	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
1064535003972	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1064535003973	protein-export membrane protein SecD; Region: secD; TIGR01129
1064535003974	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1064535003975	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1064535003976	Protein export membrane protein; Region: SecD_SecF; pfam02355
1064535003977	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
1064535003978	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
1064535003979	CPxP  motif; other site
1064535003980	DsrE/DsrF-like family; Region: DrsE; pfam02635
1064535003981	Predicted permeases [General function prediction only]; Region: COG0679
1064535003982	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535003983	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535003984	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1064535003985	dimerization interface [polypeptide binding]; other site
1064535003986	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1064535003987	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1064535003988	active site
1064535003989	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1064535003990	substrate binding site [chemical binding]; other site
1064535003991	catalytic residues [active]
1064535003992	dimer interface [polypeptide binding]; other site
1064535003993	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
1064535003994	HTH domain; Region: HTH_11; pfam08279
1064535003995	3H domain; Region: 3H; pfam02829
1064535003996	benzoate transport; Region: 2A0115; TIGR00895
1064535003997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535003998	putative substrate translocation pore; other site
1064535003999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535004000	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
1064535004001	thiamine monophosphate kinase; Provisional; Region: PRK05731
1064535004002	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1064535004003	ATP binding site [chemical binding]; other site
1064535004004	dimerization interface [polypeptide binding]; other site
1064535004005	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1064535004006	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1064535004007	Glycoprotease family; Region: Peptidase_M22; pfam00814
1064535004008	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1064535004009	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1064535004010	Coenzyme A binding pocket [chemical binding]; other site
1064535004011	UGMP family protein; Validated; Region: PRK09604
1064535004012	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1064535004013	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
1064535004014	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1064535004015	Histidine kinase; Region: HisKA_2; pfam07568
1064535004016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1064535004017	ATP binding site [chemical binding]; other site
1064535004018	Mg2+ binding site [ion binding]; other site
1064535004019	G-X-G motif; other site
1064535004020	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1064535004021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535004022	active site
1064535004023	phosphorylation site [posttranslational modification]
1064535004024	intermolecular recognition site; other site
1064535004025	dimerization interface [polypeptide binding]; other site
1064535004026	ANTAR domain; Region: ANTAR; pfam03861
1064535004027	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1064535004028	oligomerisation interface [polypeptide binding]; other site
1064535004029	mobile loop; other site
1064535004030	roof hairpin; other site
1064535004031	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1064535004032	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1064535004033	ring oligomerisation interface [polypeptide binding]; other site
1064535004034	ATP/Mg binding site [chemical binding]; other site
1064535004035	stacking interactions; other site
1064535004036	hinge regions; other site
1064535004037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535004038	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
1064535004039	Probable transposase; Region: OrfB_IS605; pfam01385
1064535004040	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535004041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535004042	putative arabinose transporter; Provisional; Region: PRK03545
1064535004043	putative substrate translocation pore; other site
1064535004044	threonine dehydratase; Provisional; Region: PRK08198
1064535004045	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1064535004046	tetramer interface [polypeptide binding]; other site
1064535004047	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535004048	catalytic residue [active]
1064535004049	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
1064535004050	putative transport protein YifK; Provisional; Region: PRK10746
1064535004051	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1064535004052	homotrimer interaction site [polypeptide binding]; other site
1064535004053	putative active site [active]
1064535004054	FOG: CBS domain [General function prediction only]; Region: COG0517
1064535004055	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1064535004056	FOG: CBS domain [General function prediction only]; Region: COG0517
1064535004057	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1064535004058	GMP synthase; Reviewed; Region: guaA; PRK00074
1064535004059	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1064535004060	AMP/PPi binding site [chemical binding]; other site
1064535004061	candidate oxyanion hole; other site
1064535004062	catalytic triad [active]
1064535004063	potential glutamine specificity residues [chemical binding]; other site
1064535004064	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1064535004065	ATP Binding subdomain [chemical binding]; other site
1064535004066	Ligand Binding sites [chemical binding]; other site
1064535004067	Dimerization subdomain; other site
1064535004068	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1064535004069	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1064535004070	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1064535004071	metal binding site [ion binding]; metal-binding site
1064535004072	active site
1064535004073	I-site; other site
1064535004074	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1064535004075	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
1064535004076	trimer interface [polypeptide binding]; other site
1064535004077	putative Zn binding site [ion binding]; other site
1064535004078	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1064535004079	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1064535004080	trimer interface [polypeptide binding]; other site
1064535004081	Haemagglutinin; Region: HIM; pfam05662
1064535004082	YadA-like C-terminal region; Region: YadA; pfam03895
1064535004083	RelB antitoxin; Region: RelB; cl01171
1064535004084	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535004085	non-specific DNA binding site [nucleotide binding]; other site
1064535004086	salt bridge; other site
1064535004087	sequence-specific DNA binding site [nucleotide binding]; other site
1064535004088	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535004089	non-specific DNA binding site [nucleotide binding]; other site
1064535004090	salt bridge; other site
1064535004091	sequence-specific DNA binding site [nucleotide binding]; other site
1064535004092	Uncharacterized protein conserved in archaea (DUF2180); Region: DUF2180; cl02017
1064535004093	Protein of unknown function (DUF739); Region: DUF739; pfam05339
1064535004094	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1064535004095	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535004096	S-adenosylmethionine binding site [chemical binding]; other site
1064535004097	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1064535004098	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1064535004099	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1064535004100	NAD binding site [chemical binding]; other site
1064535004101	dimer interface [polypeptide binding]; other site
1064535004102	substrate binding site [chemical binding]; other site
1064535004103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535004104	S-adenosylmethionine binding site [chemical binding]; other site
1064535004105	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
1064535004106	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
1064535004107	Membrane transport protein; Region: Mem_trans; pfam03547
1064535004108	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1064535004109	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1064535004110	putative active site [active]
1064535004111	putative NTP binding site [chemical binding]; other site
1064535004112	putative nucleic acid binding site [nucleotide binding]; other site
1064535004113	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1064535004114	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
1064535004115	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1064535004116	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1064535004117	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1064535004118	FMN binding site [chemical binding]; other site
1064535004119	dimer interface [polypeptide binding]; other site
1064535004120	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1064535004121	beta-galactosidase; Region: BGL; TIGR03356
1064535004122	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
1064535004123	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234
1064535004124	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1064535004125	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1064535004126	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1064535004127	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1064535004128	Predicted transcriptional regulators [Transcription]; Region: COG1733
1064535004129	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1064535004130	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1064535004131	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1064535004132	active site
1064535004133	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
1064535004134	Probable transposase; Region: OrfB_IS605; pfam01385
1064535004135	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535004136	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
1064535004137	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535004138	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1064535004139	Probable transposase; Region: OrfB_IS605; pfam01385
1064535004140	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1064535004141	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1064535004142	Cupin domain; Region: Cupin_2; pfam07883
1064535004143	Flavin Reductases; Region: FlaRed; cl00801
1064535004144	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1064535004145	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1064535004146	active site
1064535004147	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
1064535004148	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535004149	S-adenosylmethionine binding site [chemical binding]; other site
1064535004150	peptidase T; Region: peptidase-T; TIGR01882
1064535004151	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1064535004152	metal binding site [ion binding]; metal-binding site
1064535004153	dimer interface [polypeptide binding]; other site
1064535004154	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1064535004155	trimer interface [polypeptide binding]; other site
1064535004156	active site
1064535004157	Predicted transcriptional regulators [Transcription]; Region: COG1733
1064535004158	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1064535004159	dimerization interface [polypeptide binding]; other site
1064535004160	putative DNA binding site [nucleotide binding]; other site
1064535004161	putative Zn2+ binding site [ion binding]; other site
1064535004162	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1064535004163	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1064535004164	active site
1064535004165	catalytic residues [active]
1064535004166	metal binding site [ion binding]; metal-binding site
1064535004167	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1064535004168	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1064535004169	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1064535004170	Double zinc ribbon; Region: DZR; pfam12773
1064535004171	Double zinc ribbon; Region: DZR; pfam12773
1064535004172	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1064535004173	Repair protein; Region: Repair_PSII; pfam04536
1064535004174	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1064535004175	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1064535004176	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1064535004177	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1064535004178	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
1064535004179	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1064535004180	ZIP Zinc transporter; Region: Zip; pfam02535
1064535004181	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1064535004182	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1064535004183	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1064535004184	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1064535004185	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1064535004186	pyruvate kinase; Provisional; Region: PRK06354
1064535004187	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1064535004188	domain interfaces; other site
1064535004189	active site
1064535004190	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1064535004191	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1064535004192	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1064535004193	active site
1064535004194	NTP binding site [chemical binding]; other site
1064535004195	metal binding triad [ion binding]; metal-binding site
1064535004196	antibiotic binding site [chemical binding]; other site
1064535004197	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552
1064535004198	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1064535004199	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1064535004200	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1064535004201	catalytic residue [active]
1064535004202	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
1064535004203	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1064535004204	RNA/DNA hybrid binding site [nucleotide binding]; other site
1064535004205	active site
1064535004206	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535004207	4Fe-4S binding domain; Region: Fer4; pfam00037
1064535004208	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
1064535004209	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1064535004210	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1064535004211	active site
1064535004212	FMN binding site [chemical binding]; other site
1064535004213	substrate binding site [chemical binding]; other site
1064535004214	putative catalytic residues [active]
1064535004215	Protein of unknown function (DUF535); Region: DUF535; cl01128
1064535004216	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1064535004217	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1064535004218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535004219	Walker A/P-loop; other site
1064535004220	ATP binding site [chemical binding]; other site
1064535004221	Q-loop/lid; other site
1064535004222	ABC transporter signature motif; other site
1064535004223	Walker B; other site
1064535004224	D-loop; other site
1064535004225	H-loop/switch region; other site
1064535004226	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1064535004227	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1064535004228	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535004229	Walker A/P-loop; other site
1064535004230	ATP binding site [chemical binding]; other site
1064535004231	Q-loop/lid; other site
1064535004232	ABC transporter signature motif; other site
1064535004233	Walker B; other site
1064535004234	D-loop; other site
1064535004235	H-loop/switch region; other site
1064535004236	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850
1064535004237	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1064535004238	UvrB/uvrC motif; Region: UVR; pfam02151
1064535004239	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
1064535004240	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1064535004241	ADP binding site [chemical binding]; other site
1064535004242	phosphagen binding site; other site
1064535004243	substrate specificity loop; other site
1064535004244	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1064535004245	Clp amino terminal domain; Region: Clp_N; pfam02861
1064535004246	Clp amino terminal domain; Region: Clp_N; pfam02861
1064535004247	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535004248	Walker A motif; other site
1064535004249	ATP binding site [chemical binding]; other site
1064535004250	Walker B motif; other site
1064535004251	arginine finger; other site
1064535004252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535004253	Walker A motif; other site
1064535004254	ATP binding site [chemical binding]; other site
1064535004255	Walker B motif; other site
1064535004256	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1064535004257	DNA repair protein RadA; Provisional; Region: PRK11823
1064535004258	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1064535004259	Walker A motif/ATP binding site; other site
1064535004260	ATP binding site [chemical binding]; other site
1064535004261	Walker B motif; other site
1064535004262	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1064535004263	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
1064535004264	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1064535004265	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535004266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535004267	homodimer interface [polypeptide binding]; other site
1064535004268	catalytic residue [active]
1064535004269	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1064535004270	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1064535004271	active site
1064535004272	FMN binding site [chemical binding]; other site
1064535004273	substrate binding site [chemical binding]; other site
1064535004274	putative catalytic residue [active]
1064535004275	Predicted transcriptional regulators [Transcription]; Region: COG1733
1064535004276	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1064535004277	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
1064535004278	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
1064535004279	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
1064535004280	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
1064535004281	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
1064535004282	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
1064535004283	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
1064535004284	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
1064535004285	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
1064535004286	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
1064535004287	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1064535004288	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535004289	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535004290	homodimer interface [polypeptide binding]; other site
1064535004291	catalytic residue [active]
1064535004292	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1064535004293	active site
1064535004294	8-oxo-dGMP binding site [chemical binding]; other site
1064535004295	nudix motif; other site
1064535004296	metal binding site [ion binding]; metal-binding site
1064535004297	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
1064535004298	PLD-like domain; Region: PLDc_2; pfam13091
1064535004299	putative homodimer interface [polypeptide binding]; other site
1064535004300	putative active site [active]
1064535004301	catalytic site [active]
1064535004302	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1064535004303	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1064535004304	ATP binding site [chemical binding]; other site
1064535004305	putative Mg++ binding site [ion binding]; other site
1064535004306	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1064535004307	nucleotide binding region [chemical binding]; other site
1064535004308	ATP-binding site [chemical binding]; other site
1064535004309	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1064535004310	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1064535004311	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1064535004312	putative active site [active]
1064535004313	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
1064535004314	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1064535004315	substrate binding site; other site
1064535004316	dimer interface; other site
1064535004317	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1064535004318	homotrimer interaction site [polypeptide binding]; other site
1064535004319	zinc binding site [ion binding]; other site
1064535004320	CDP-binding sites; other site
1064535004321	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1064535004322	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1064535004323	active site
1064535004324	HIGH motif; other site
1064535004325	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1064535004326	active site
1064535004327	KMSKS motif; other site
1064535004328	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1064535004329	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1064535004330	active site
1064535004331	HIGH motif; other site
1064535004332	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1064535004333	KMSKS motif; other site
1064535004334	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1064535004335	tRNA binding surface [nucleotide binding]; other site
1064535004336	anticodon binding site; other site
1064535004337	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
1064535004338	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1064535004339	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1064535004340	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1064535004341	RNA polymerase factor sigma-70; Validated; Region: PRK08295
1064535004342	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1064535004343	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1064535004344	DNA binding residues [nucleotide binding]
1064535004345	ribonuclease R; Region: RNase_R; TIGR02063
1064535004346	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1064535004347	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1064535004348	RNB domain; Region: RNB; pfam00773
1064535004349	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1064535004350	RNA binding site [nucleotide binding]; other site
1064535004351	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1064535004352	SmpB-tmRNA interface; other site
1064535004353	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
1064535004354	DNA polymerase I; Provisional; Region: PRK05755
1064535004355	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1064535004356	active site
1064535004357	metal binding site 1 [ion binding]; metal-binding site
1064535004358	putative 5' ssDNA interaction site; other site
1064535004359	metal binding site 3; metal-binding site
1064535004360	metal binding site 2 [ion binding]; metal-binding site
1064535004361	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1064535004362	putative DNA binding site [nucleotide binding]; other site
1064535004363	putative metal binding site [ion binding]; other site
1064535004364	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1064535004365	active site
1064535004366	catalytic site [active]
1064535004367	substrate binding site [chemical binding]; other site
1064535004368	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1064535004369	active site
1064535004370	DNA binding site [nucleotide binding]
1064535004371	catalytic site [active]
1064535004372	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1064535004373	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1064535004374	DNA binding site [nucleotide binding]
1064535004375	catalytic residue [active]
1064535004376	H2TH interface [polypeptide binding]; other site
1064535004377	putative catalytic residues [active]
1064535004378	turnover-facilitating residue; other site
1064535004379	intercalation triad [nucleotide binding]; other site
1064535004380	8OG recognition residue [nucleotide binding]; other site
1064535004381	putative reading head residues; other site
1064535004382	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1064535004383	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1064535004384	Domain of unknown function (DUF389); Region: DUF389; pfam04087
1064535004385	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1064535004386	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1064535004387	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1064535004388	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1064535004389	Predicted membrane protein [Function unknown]; Region: COG2855
1064535004390	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1064535004391	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535004392	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1064535004393	putative dimerization interface [polypeptide binding]; other site
1064535004394	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1064535004395	putative Zn2+ binding site [ion binding]; other site
1064535004396	putative DNA binding site [nucleotide binding]; other site
1064535004397	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
1064535004398	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1064535004399	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1064535004400	Ligand binding site; other site
1064535004401	Putative Catalytic site; other site
1064535004402	DXD motif; other site
1064535004403	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1064535004404	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1064535004405	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1064535004406	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1064535004407	CoA-binding site [chemical binding]; other site
1064535004408	ATP-binding [chemical binding]; other site
1064535004409	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1064535004410	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1064535004411	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1064535004412	catalytic residue [active]
1064535004413	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1064535004414	Sm and related proteins; Region: Sm_like; cl00259
1064535004415	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1064535004416	putative oligomer interface [polypeptide binding]; other site
1064535004417	putative RNA binding site [nucleotide binding]; other site
1064535004418	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1064535004419	NusA N-terminal domain; Region: NusA_N; pfam08529
1064535004420	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1064535004421	RNA binding site [nucleotide binding]; other site
1064535004422	homodimer interface [polypeptide binding]; other site
1064535004423	NusA-like KH domain; Region: KH_5; pfam13184
1064535004424	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1064535004425	G-X-X-G motif; other site
1064535004426	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1064535004427	putative RNA binding cleft [nucleotide binding]; other site
1064535004428	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1064535004429	translation initiation factor IF-2; Region: IF-2; TIGR00487
1064535004430	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1064535004431	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1064535004432	G1 box; other site
1064535004433	putative GEF interaction site [polypeptide binding]; other site
1064535004434	GTP/Mg2+ binding site [chemical binding]; other site
1064535004435	Switch I region; other site
1064535004436	G2 box; other site
1064535004437	G3 box; other site
1064535004438	Switch II region; other site
1064535004439	G4 box; other site
1064535004440	G5 box; other site
1064535004441	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1064535004442	Translation-initiation factor 2; Region: IF-2; pfam11987
1064535004443	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1064535004444	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1064535004445	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1064535004446	DHH family; Region: DHH; pfam01368
1064535004447	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
1064535004448	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1064535004449	RNA binding site [nucleotide binding]; other site
1064535004450	active site
1064535004451	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1064535004452	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1064535004453	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1064535004454	active site
1064535004455	Riboflavin kinase; Region: Flavokinase; pfam01687
1064535004456	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1064535004457	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535004458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535004459	homodimer interface [polypeptide binding]; other site
1064535004460	catalytic residue [active]
1064535004461	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1064535004462	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535004463	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535004464	homodimer interface [polypeptide binding]; other site
1064535004465	catalytic residue [active]
1064535004466	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1064535004467	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1064535004468	ATP binding site [chemical binding]; other site
1064535004469	putative Mg++ binding site [ion binding]; other site
1064535004470	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1064535004471	nucleotide binding region [chemical binding]; other site
1064535004472	ATP-binding site [chemical binding]; other site
1064535004473	RQC domain; Region: RQC; pfam09382
1064535004474	HRDC domain; Region: HRDC; pfam00570
1064535004475	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1064535004476	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1064535004477	dimerization interface [polypeptide binding]; other site
1064535004478	active site
1064535004479	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1064535004480	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1064535004481	folate binding site [chemical binding]; other site
1064535004482	NADP+ binding site [chemical binding]; other site
1064535004483	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1064535004484	DNA-binding site [nucleotide binding]; DNA binding site
1064535004485	RNA-binding motif; other site
1064535004486	ornithine carbamoyltransferase; Provisional; Region: PRK14804
1064535004487	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1064535004488	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1064535004489	Predicted permeases [General function prediction only]; Region: COG0679
1064535004490	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535004491	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535004492	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1064535004493	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1064535004494	EamA-like transporter family; Region: EamA; pfam00892
1064535004495	EamA-like transporter family; Region: EamA; pfam00892
1064535004496	CpXC protein; Region: CpXC; pfam14353
1064535004497	CGGC domain; Region: CGGC; cl02356
1064535004498	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1064535004499	TPR repeat; Region: TPR_11; pfam13414
1064535004500	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1064535004501	binding surface
1064535004502	TPR motif; other site
1064535004503	TPR repeat; Region: TPR_11; pfam13414
1064535004504	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1064535004505	binding surface
1064535004506	TPR repeat; Region: TPR_11; pfam13414
1064535004507	TPR motif; other site
1064535004508	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1064535004509	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1064535004510	Walker A/P-loop; other site
1064535004511	ATP binding site [chemical binding]; other site
1064535004512	Q-loop/lid; other site
1064535004513	ABC transporter signature motif; other site
1064535004514	Walker B; other site
1064535004515	D-loop; other site
1064535004516	H-loop/switch region; other site
1064535004517	Cobalt transport protein; Region: CbiQ; cl00463
1064535004518	cobalt transport protein CbiM; Provisional; Region: PRK07331
1064535004519	cobalt transport protein CbiM; Provisional; Region: PRK11909
1064535004520	PDGLE domain; Region: PDGLE; pfam13190
1064535004521	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
1064535004522	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1064535004523	Haemagglutinin; Region: HIM; pfam05662
1064535004524	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1064535004525	trimer interface [polypeptide binding]; other site
1064535004526	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1064535004527	trimer interface [polypeptide binding]; other site
1064535004528	YadA-like C-terminal region; Region: YadA; pfam03895
1064535004529	RelB antitoxin; Region: RelB; cl01171
1064535004530	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1064535004531	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535004532	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1064535004533	Probable transposase; Region: OrfB_IS605; pfam01385
1064535004534	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535004535	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1064535004536	Spore germination protein; Region: Spore_permease; cl17796
1064535004537	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
1064535004538	glycerate dehydrogenase; Provisional; Region: PRK06436
1064535004539	NAD binding site [chemical binding]; other site
1064535004540	ligand binding site [chemical binding]; other site
1064535004541	catalytic site [active]
1064535004542	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1064535004543	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1064535004544	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1064535004545	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1064535004546	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535004547	non-specific DNA binding site [nucleotide binding]; other site
1064535004548	salt bridge; other site
1064535004549	sequence-specific DNA binding site [nucleotide binding]; other site
1064535004550	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1064535004551	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1064535004552	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1064535004553	active site
1064535004554	metal binding site [ion binding]; metal-binding site
1064535004555	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1064535004556	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1064535004557	SLBB domain; Region: SLBB; pfam10531
1064535004558	comEA protein; Region: comE; TIGR01259
1064535004559	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1064535004560	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1064535004561	Competence protein; Region: Competence; pfam03772
1064535004562	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1064535004563	VanW like protein; Region: VanW; pfam04294
1064535004564	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535004565	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
1064535004566	Probable transposase; Region: OrfB_IS605; pfam01385
1064535004567	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535004568	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1064535004569	generic binding surface II; other site
1064535004570	generic binding surface I; other site
1064535004571	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1064535004572	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
1064535004573	active site
1064535004574	putative PHP Thumb interface [polypeptide binding]; other site
1064535004575	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1064535004576	Trp repressor protein; Region: Trp_repressor; cl17266
1064535004577	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1064535004578	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
1064535004579	N- and C-terminal domain interface [polypeptide binding]; other site
1064535004580	putative active site [active]
1064535004581	MgATP binding site [chemical binding]; other site
1064535004582	catalytic site [active]
1064535004583	metal binding site [ion binding]; metal-binding site
1064535004584	putative xylulose binding site [chemical binding]; other site
1064535004585	putative homodimer interface [polypeptide binding]; other site
1064535004586	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
1064535004587	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1064535004588	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1064535004589	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
1064535004590	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1064535004591	substrate binding site [chemical binding]; other site
1064535004592	oxyanion hole (OAH) forming residues; other site
1064535004593	trimer interface [polypeptide binding]; other site
1064535004594	Predicted peptidase [General function prediction only]; Region: COG4099
1064535004595	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1064535004596	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1064535004597	GrpE; Region: GrpE; pfam01025
1064535004598	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1064535004599	dimer interface [polypeptide binding]; other site
1064535004600	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1064535004601	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1064535004602	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1064535004603	nucleotide binding site [chemical binding]; other site
1064535004604	NEF interaction site [polypeptide binding]; other site
1064535004605	SBD interface [polypeptide binding]; other site
1064535004606	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
1064535004607	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1064535004608	HSP70 interaction site [polypeptide binding]; other site
1064535004609	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1064535004610	substrate binding site [polypeptide binding]; other site
1064535004611	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1064535004612	Zn binding sites [ion binding]; other site
1064535004613	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1064535004614	dimer interface [polypeptide binding]; other site
1064535004615	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
1064535004616	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1064535004617	RNA methyltransferase, RsmE family; Region: TIGR00046
1064535004618	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1064535004619	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1064535004620	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535004621	FeS/SAM binding site; other site
1064535004622	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1064535004623	nucleotide binding site/active site [active]
1064535004624	HIT family signature motif; other site
1064535004625	catalytic residue [active]
1064535004626	hypothetical protein; Reviewed; Region: PRK12497
1064535004627	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1064535004628	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1064535004629	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535004630	Walker A motif; other site
1064535004631	ATP binding site [chemical binding]; other site
1064535004632	Walker B motif; other site
1064535004633	arginine finger; other site
1064535004634	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1064535004635	DNA protecting protein DprA; Region: dprA; TIGR00732
1064535004636	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1064535004637	bifunctional UGMP family protein/serine/threonine protein kinase; Validated; Region: PRK09605
1064535004638	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1064535004639	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1064535004640	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535004641	motif II; other site
1064535004642	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
1064535004643	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1064535004644	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
1064535004645	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1064535004646	G1 box; other site
1064535004647	GTP/Mg2+ binding site [chemical binding]; other site
1064535004648	Switch I region; other site
1064535004649	G2 box; other site
1064535004650	G3 box; other site
1064535004651	Switch II region; other site
1064535004652	G4 box; other site
1064535004653	G5 box; other site
1064535004654	Nucleoside recognition; Region: Gate; pfam07670
1064535004655	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1064535004656	Nucleoside recognition; Region: Gate; pfam07670
1064535004657	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1064535004658	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1064535004659	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1064535004660	TPR motif; other site
1064535004661	TPR repeat; Region: TPR_11; pfam13414
1064535004662	binding surface
1064535004663	TPR repeat; Region: TPR_11; pfam13414
1064535004664	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1064535004665	binding surface
1064535004666	TPR motif; other site
1064535004667	TPR repeat; Region: TPR_11; pfam13414
1064535004668	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1064535004669	binding surface
1064535004670	TPR motif; other site
1064535004671	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1064535004672	Beta-lactamase; Region: Beta-lactamase; pfam00144
1064535004673	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1064535004674	alanine racemase; Reviewed; Region: alr; PRK00053
1064535004675	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1064535004676	active site
1064535004677	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1064535004678	dimer interface [polypeptide binding]; other site
1064535004679	substrate binding site [chemical binding]; other site
1064535004680	catalytic residues [active]
1064535004681	hypothetical protein; Validated; Region: PRK07682
1064535004682	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535004683	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535004684	homodimer interface [polypeptide binding]; other site
1064535004685	catalytic residue [active]
1064535004686	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1064535004687	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1064535004688	FtsH Extracellular; Region: FtsH_ext; pfam06480
1064535004689	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1064535004690	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1064535004691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535004692	Walker A motif; other site
1064535004693	ATP binding site [chemical binding]; other site
1064535004694	Walker B motif; other site
1064535004695	arginine finger; other site
1064535004696	Peptidase family M41; Region: Peptidase_M41; pfam01434
1064535004697	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1064535004698	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535004699	Walker A/P-loop; other site
1064535004700	ATP binding site [chemical binding]; other site
1064535004701	Q-loop/lid; other site
1064535004702	ABC transporter signature motif; other site
1064535004703	Walker B; other site
1064535004704	D-loop; other site
1064535004705	H-loop/switch region; other site
1064535004706	ABC transporter; Region: ABC_tran_2; pfam12848
1064535004707	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1064535004708	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
1064535004709	4Fe-4S binding domain; Region: Fer4; pfam00037
1064535004710	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
1064535004711	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
1064535004712	S-layer homology domain; Region: SLH; pfam00395
1064535004713	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1064535004714	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1064535004715	active site
1064535004716	metal binding site [ion binding]; metal-binding site
1064535004717	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1064535004718	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1064535004719	Protein of unknown function (DUF464); Region: DUF464; pfam04327
1064535004720	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1064535004721	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1064535004722	putative active site [active]
1064535004723	putative metal binding site [ion binding]; other site
1064535004724	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1064535004725	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1064535004726	metal-dependent hydrolase; Provisional; Region: PRK00685
1064535004727	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1064535004728	Protein of unknown function (DUF964); Region: DUF964; cl01483
1064535004729	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1064535004730	FAD binding domain; Region: FAD_binding_4; pfam01565
1064535004731	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1064535004732	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
1064535004733	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1064535004734	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1064535004735	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1064535004736	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1064535004737	G1 box; other site
1064535004738	putative GEF interaction site [polypeptide binding]; other site
1064535004739	GTP/Mg2+ binding site [chemical binding]; other site
1064535004740	Switch I region; other site
1064535004741	G2 box; other site
1064535004742	G3 box; other site
1064535004743	Switch II region; other site
1064535004744	G4 box; other site
1064535004745	G5 box; other site
1064535004746	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1064535004747	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1064535004748	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
1064535004749	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
1064535004750	Uncharacterized conserved protein [Function unknown]; Region: COG2006
1064535004751	propionate catabolism operon regulatory protein PrpR; Region: propionate_PrpR; TIGR02329
1064535004752	Propionate catabolism activator; Region: PrpR_N; pfam06506
1064535004753	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535004754	Walker A motif; other site
1064535004755	ATP binding site [chemical binding]; other site
1064535004756	Walker B motif; other site
1064535004757	arginine finger; other site
1064535004758	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1064535004759	DNA-binding interface [nucleotide binding]; DNA binding site
1064535004760	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1064535004761	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1064535004762	trimer interface [polypeptide binding]; other site
1064535004763	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1064535004764	trimer interface [polypeptide binding]; other site
1064535004765	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1064535004766	trimer interface [polypeptide binding]; other site
1064535004767	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1064535004768	trimer interface [polypeptide binding]; other site
1064535004769	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
1064535004770	Haemagglutinin; Region: HIM; pfam05662
1064535004771	S-layer homology domain; Region: SLH; pfam00395
1064535004772	RelB antitoxin; Region: RelB; cl01171
1064535004773	Helix-turn-helix domain; Region: HTH_38; pfam13936
1064535004774	DNA-binding interface [nucleotide binding]; DNA binding site
1064535004775	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1064535004776	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1064535004777	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535004778	FeS/SAM binding site; other site
1064535004779	TRAM domain; Region: TRAM; pfam01938
1064535004780	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1064535004781	MutS domain I; Region: MutS_I; pfam01624
1064535004782	MutS domain II; Region: MutS_II; pfam05188
1064535004783	MutS domain III; Region: MutS_III; pfam05192
1064535004784	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1064535004785	Walker A/P-loop; other site
1064535004786	ATP binding site [chemical binding]; other site
1064535004787	Q-loop/lid; other site
1064535004788	ABC transporter signature motif; other site
1064535004789	Walker B; other site
1064535004790	D-loop; other site
1064535004791	H-loop/switch region; other site
1064535004792	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
1064535004793	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1064535004794	ATP binding site [chemical binding]; other site
1064535004795	Mg2+ binding site [ion binding]; other site
1064535004796	G-X-G motif; other site
1064535004797	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1064535004798	ATP binding site [chemical binding]; other site
1064535004799	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
1064535004800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535004801	S-adenosylmethionine binding site [chemical binding]; other site
1064535004802	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1064535004803	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1064535004804	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1064535004805	Aluminium resistance protein; Region: Alum_res; pfam06838
1064535004806	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1064535004807	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1064535004808	putative active site [active]
1064535004809	putative metal binding site [ion binding]; other site
1064535004810	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1064535004811	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1064535004812	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535004813	S-adenosylmethionine binding site [chemical binding]; other site
1064535004814	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1064535004815	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1064535004816	ATP binding site [chemical binding]; other site
1064535004817	Mg++ binding site [ion binding]; other site
1064535004818	motif III; other site
1064535004819	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1064535004820	nucleotide binding region [chemical binding]; other site
1064535004821	ATP-binding site [chemical binding]; other site
1064535004822	2-isopropylmalate synthase; Validated; Region: PRK03739
1064535004823	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1064535004824	active site
1064535004825	catalytic residues [active]
1064535004826	metal binding site [ion binding]; metal-binding site
1064535004827	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1064535004828	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1064535004829	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1064535004830	substrate binding site [chemical binding]; other site
1064535004831	ligand binding site [chemical binding]; other site
1064535004832	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
1064535004833	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1064535004834	substrate binding site [chemical binding]; other site
1064535004835	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1064535004836	tartrate dehydrogenase; Region: TTC; TIGR02089
1064535004837	DNA topoisomerase I; Validated; Region: PRK05582
1064535004838	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1064535004839	active site
1064535004840	interdomain interaction site; other site
1064535004841	putative metal-binding site [ion binding]; other site
1064535004842	nucleotide binding site [chemical binding]; other site
1064535004843	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1064535004844	domain I; other site
1064535004845	DNA binding groove [nucleotide binding]
1064535004846	phosphate binding site [ion binding]; other site
1064535004847	domain II; other site
1064535004848	domain III; other site
1064535004849	nucleotide binding site [chemical binding]; other site
1064535004850	catalytic site [active]
1064535004851	domain IV; other site
1064535004852	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1064535004853	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1064535004854	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1064535004855	Glucose inhibited division protein A; Region: GIDA; pfam01134
1064535004856	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1064535004857	active site
1064535004858	HslU subunit interaction site [polypeptide binding]; other site
1064535004859	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1064535004860	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1064535004861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535004862	Walker A motif; other site
1064535004863	ATP binding site [chemical binding]; other site
1064535004864	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1064535004865	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1064535004866	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
1064535004867	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1064535004868	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1064535004869	putative RNA binding site [nucleotide binding]; other site
1064535004870	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535004871	S-adenosylmethionine binding site [chemical binding]; other site
1064535004872	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
1064535004873	YcfA-like protein; Region: YcfA; pfam07927
1064535004874	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
1064535004875	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1064535004876	non-specific DNA binding site [nucleotide binding]; other site
1064535004877	salt bridge; other site
1064535004878	sequence-specific DNA binding site [nucleotide binding]; other site
1064535004879	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1064535004880	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1064535004881	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1064535004882	Predicted membrane protein [Function unknown]; Region: COG4684
1064535004883	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1064535004884	rod shape-determining protein MreB; Provisional; Region: PRK13930
1064535004885	MreB and similar proteins; Region: MreB_like; cd10225
1064535004886	nucleotide binding site [chemical binding]; other site
1064535004887	Mg binding site [ion binding]; other site
1064535004888	putative protofilament interaction site [polypeptide binding]; other site
1064535004889	RodZ interaction site [polypeptide binding]; other site
1064535004890	rod shape-determining protein MreC; Provisional; Region: PRK13922
1064535004891	rod shape-determining protein MreC; Region: MreC; pfam04085
1064535004892	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
1064535004893	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1064535004894	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1064535004895	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1064535004896	septum site-determining protein MinD; Region: minD_bact; TIGR01968
1064535004897	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1064535004898	P-loop; other site
1064535004899	ADP binding residues [chemical binding]; other site
1064535004900	Switch I; other site
1064535004901	Switch II; other site
1064535004902	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1064535004903	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
1064535004904	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535004905	FeS/SAM binding site; other site
1064535004906	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
1064535004907	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
1064535004908	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1064535004909	active site
1064535004910	SAM binding site [chemical binding]; other site
1064535004911	homodimer interface [polypeptide binding]; other site
1064535004912	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1064535004913	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1064535004914	homodimer interface [polypeptide binding]; other site
1064535004915	oligonucleotide binding site [chemical binding]; other site
1064535004916	Cache domain; Region: Cache_1; pfam02743
1064535004917	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1064535004918	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1064535004919	dimerization interface [polypeptide binding]; other site
1064535004920	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1064535004921	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1064535004922	metal binding site [ion binding]; metal-binding site
1064535004923	active site
1064535004924	I-site; other site
1064535004925	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1064535004926	TrkA-N domain; Region: TrkA_N; pfam02254
1064535004927	TrkA-C domain; Region: TrkA_C; pfam02080
1064535004928	TrkA-N domain; Region: TrkA_N; pfam02254
1064535004929	TrkA-C domain; Region: TrkA_C; pfam02080
1064535004930	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1064535004931	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1064535004932	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1064535004933	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1064535004934	Type II/IV secretion system protein; Region: T2SE; pfam00437
1064535004935	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1064535004936	Walker A motif; other site
1064535004937	ATP binding site [chemical binding]; other site
1064535004938	Walker B motif; other site
1064535004939	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1064535004940	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535004941	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1064535004942	Walker A motif; other site
1064535004943	Walker A/P-loop; other site
1064535004944	ATP binding site [chemical binding]; other site
1064535004945	ATP binding site [chemical binding]; other site
1064535004946	Walker B motif; other site
1064535004947	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1064535004948	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1064535004949	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1064535004950	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1064535004951	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1064535004952	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1064535004953	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
1064535004954	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
1064535004955	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1064535004956	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1064535004957	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1064535004958	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1064535004959	N-terminal plug; other site
1064535004960	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1064535004961	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1064535004962	intersubunit interface [polypeptide binding]; other site
1064535004963	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1064535004964	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1064535004965	ABC-ATPase subunit  interface; other site
1064535004966	dimer interface [polypeptide binding]; other site
1064535004967	putative PBP binding regions; other site
1064535004968	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1064535004969	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1064535004970	Walker A/P-loop; other site
1064535004971	ATP binding site [chemical binding]; other site
1064535004972	Q-loop/lid; other site
1064535004973	ABC transporter signature motif; other site
1064535004974	Walker B; other site
1064535004975	D-loop; other site
1064535004976	H-loop/switch region; other site
1064535004977	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1064535004978	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1064535004979	active site
1064535004980	SAM binding site [chemical binding]; other site
1064535004981	homodimer interface [polypeptide binding]; other site
1064535004982	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
1064535004983	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1064535004984	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1064535004985	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1064535004986	active site
1064535004987	SAM binding site [chemical binding]; other site
1064535004988	homodimer interface [polypeptide binding]; other site
1064535004989	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
1064535004990	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1064535004991	active site
1064535004992	putative homodimer interface [polypeptide binding]; other site
1064535004993	SAM binding site [chemical binding]; other site
1064535004994	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1064535004995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535004996	S-adenosylmethionine binding site [chemical binding]; other site
1064535004997	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1064535004998	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1064535004999	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1064535005000	catalytic triad [active]
1064535005001	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1064535005002	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
1064535005003	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1064535005004	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1064535005005	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1064535005006	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1064535005007	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1064535005008	GatB domain; Region: GatB_Yqey; smart00845
1064535005009	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1064535005010	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1064535005011	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1064535005012	active site
1064535005013	HIGH motif; other site
1064535005014	nucleotide binding site [chemical binding]; other site
1064535005015	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1064535005016	KMSKS motif; other site
1064535005017	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1064535005018	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
1064535005019	Maf-like protein; Region: Maf; pfam02545
1064535005020	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1064535005021	active site
1064535005022	dimer interface [polypeptide binding]; other site
1064535005023	hypothetical protein; Reviewed; Region: PRK00024
1064535005024	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1064535005025	MPN+ (JAMM) motif; other site
1064535005026	Zinc-binding site [ion binding]; other site
1064535005027	Flavodoxin domain; Region: Flavodoxin_5; cl17428
1064535005028	4Fe-4S binding domain; Region: Fer4; pfam00037
1064535005029	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
1064535005030	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1064535005031	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1064535005032	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1064535005033	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1064535005034	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535005035	catalytic residue [active]
1064535005036	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1064535005037	EamA-like transporter family; Region: EamA; pfam00892
1064535005038	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1064535005039	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1064535005040	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1064535005041	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1064535005042	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1064535005043	active site
1064535005044	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1064535005045	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1064535005046	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1064535005047	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1064535005048	catalytic residue [active]
1064535005049	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1064535005050	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1064535005051	Walker A/P-loop; other site
1064535005052	ATP binding site [chemical binding]; other site
1064535005053	Q-loop/lid; other site
1064535005054	ABC transporter signature motif; other site
1064535005055	Walker B; other site
1064535005056	D-loop; other site
1064535005057	H-loop/switch region; other site
1064535005058	TOBE domain; Region: TOBE_2; pfam08402
1064535005059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535005060	dimer interface [polypeptide binding]; other site
1064535005061	conserved gate region; other site
1064535005062	ABC-ATPase subunit interface; other site
1064535005063	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1064535005064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535005065	dimer interface [polypeptide binding]; other site
1064535005066	conserved gate region; other site
1064535005067	putative PBP binding loops; other site
1064535005068	ABC-ATPase subunit interface; other site
1064535005069	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1064535005070	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1064535005071	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1064535005072	ATP binding site [chemical binding]; other site
1064535005073	active site
1064535005074	substrate binding site [chemical binding]; other site
1064535005075	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1064535005076	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
1064535005077	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
1064535005078	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1064535005079	Na binding site [ion binding]; other site
1064535005080	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1064535005081	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
1064535005082	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
1064535005083	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
1064535005084	lysine transporter; Provisional; Region: PRK10836
1064535005085	hypothetical protein; Provisional; Region: PRK07248
1064535005086	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1064535005087	AAA domain; Region: AAA_30; pfam13604
1064535005088	Family description; Region: UvrD_C_2; pfam13538
1064535005089	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1064535005090	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1064535005091	active site
1064535005092	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1064535005093	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1064535005094	Transposase; Region: HTH_Tnp_1; cl17663
1064535005095	putative transposase OrfB; Reviewed; Region: PHA02517
1064535005096	HTH-like domain; Region: HTH_21; pfam13276
1064535005097	Integrase core domain; Region: rve; pfam00665
1064535005098	Integrase core domain; Region: rve_3; pfam13683
1064535005099	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889
1064535005100	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1064535005101	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1064535005102	active site
1064535005103	metal binding site [ion binding]; metal-binding site
1064535005104	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1064535005105	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1064535005106	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1064535005107	DNA binding residues [nucleotide binding]
1064535005108	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1064535005109	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1064535005110	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1064535005111	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1064535005112	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1064535005113	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1064535005114	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1064535005115	ATP binding site [chemical binding]; other site
1064535005116	putative Mg++ binding site [ion binding]; other site
1064535005117	Protein of unknown function (DUF541); Region: SIMPL; cl01077
1064535005118	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535005119	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535005120	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1064535005121	dimerization interface [polypeptide binding]; other site
1064535005122	Chromate transporter; Region: Chromate_transp; pfam02417
1064535005123	Chromate transporter; Region: Chromate_transp; pfam02417
1064535005124	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1064535005125	Part of AAA domain; Region: AAA_19; pfam13245
1064535005126	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1064535005127	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1064535005128	active site
1064535005129	catalytic site [active]
1064535005130	substrate binding site [chemical binding]; other site
1064535005131	Family description; Region: UvrD_C_2; pfam13538
1064535005132	AIR carboxylase; Region: AIRC; pfam00731
1064535005133	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
1064535005134	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1064535005135	active site
1064535005136	tetramer interface [polypeptide binding]; other site
1064535005137	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1064535005138	active site
1064535005139	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1064535005140	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1064535005141	dimerization interface [polypeptide binding]; other site
1064535005142	putative ATP binding site [chemical binding]; other site
1064535005143	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1064535005144	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1064535005145	active site
1064535005146	substrate binding site [chemical binding]; other site
1064535005147	cosubstrate binding site; other site
1064535005148	catalytic site [active]
1064535005149	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1064535005150	purine monophosphate binding site [chemical binding]; other site
1064535005151	dimer interface [polypeptide binding]; other site
1064535005152	putative catalytic residues [active]
1064535005153	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1064535005154	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1064535005155	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1064535005156	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1064535005157	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1064535005158	Coenzyme A transferase; Region: CoA_trans; smart00882
1064535005159	Coenzyme A transferase; Region: CoA_trans; cl17247
1064535005160	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1064535005161	Class II fumarases; Region: Fumarase_classII; cd01362
1064535005162	active site
1064535005163	tetramer interface [polypeptide binding]; other site
1064535005164	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1064535005165	metal ion-dependent adhesion site (MIDAS); other site
1064535005166	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1064535005167	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1064535005168	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1064535005169	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
1064535005170	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1064535005171	MarR family; Region: MarR_2; pfam12802
1064535005172	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1064535005173	Predicted membrane protein [Function unknown]; Region: COG2364
1064535005174	MarR family; Region: MarR_2; pfam12802
1064535005175	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1064535005176	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1064535005177	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535005178	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
1064535005179	Probable transposase; Region: OrfB_IS605; pfam01385
1064535005180	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535005181	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1064535005182	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1064535005183	catalytic residues [active]
1064535005184	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1064535005185	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1064535005186	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1064535005187	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1064535005188	putative DNA binding site [nucleotide binding]; other site
1064535005189	putative Zn2+ binding site [ion binding]; other site
1064535005190	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1064535005191	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
1064535005192	putative FMN binding site [chemical binding]; other site
1064535005193	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1064535005194	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1064535005195	dimer interface [polypeptide binding]; other site
1064535005196	FMN binding site [chemical binding]; other site
1064535005197	Cupin domain; Region: Cupin_2; pfam07883
1064535005198	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1064535005199	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1064535005200	active site
1064535005201	FMN binding site [chemical binding]; other site
1064535005202	substrate binding site [chemical binding]; other site
1064535005203	putative catalytic residue [active]
1064535005204	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1064535005205	SnoaL-like domain; Region: SnoaL_4; pfam13577
1064535005206	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1064535005207	Recombinase; Region: Recombinase; pfam07508
1064535005208	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535005209	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535005210	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1064535005211	dimerization interface [polypeptide binding]; other site
1064535005212	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1064535005213	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1064535005214	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1064535005215	active site
1064535005216	catalytic tetrad [active]
1064535005217	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1064535005218	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1064535005219	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1064535005220	substrate binding pocket [chemical binding]; other site
1064535005221	catalytic triad [active]
1064535005222	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1064535005223	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535005224	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1064535005225	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1064535005226	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1064535005227	active site
1064535005228	catalytic tetrad [active]
1064535005229	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535005230	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1064535005231	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1064535005232	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1064535005233	active site
1064535005234	catalytic tetrad [active]
1064535005235	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1064535005236	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1064535005237	active site
1064535005238	FMN binding site [chemical binding]; other site
1064535005239	substrate binding site [chemical binding]; other site
1064535005240	putative catalytic residue [active]
1064535005241	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1064535005242	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535005243	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535005244	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1064535005245	dimerization interface [polypeptide binding]; other site
1064535005246	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1064535005247	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1064535005248	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1064535005249	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1064535005250	LysE type translocator; Region: LysE; cl00565
1064535005251	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1064535005252	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1064535005253	DNA-binding site [nucleotide binding]; DNA binding site
1064535005254	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535005255	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535005256	homodimer interface [polypeptide binding]; other site
1064535005257	catalytic residue [active]
1064535005258	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1064535005259	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1064535005260	active site
1064535005261	FMN binding site [chemical binding]; other site
1064535005262	substrate binding site [chemical binding]; other site
1064535005263	putative catalytic residue [active]
1064535005264	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1064535005265	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1064535005266	active site
1064535005267	metal binding site [ion binding]; metal-binding site
1064535005268	homotetramer interface [polypeptide binding]; other site
1064535005269	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1064535005270	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1064535005271	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535005272	catalytic residue [active]
1064535005273	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1064535005274	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1064535005275	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1064535005276	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1064535005277	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1064535005278	glutamine binding [chemical binding]; other site
1064535005279	catalytic triad [active]
1064535005280	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1064535005281	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
1064535005282	putative active site [active]
1064535005283	catalytic triad [active]
1064535005284	putative dimer interface [polypeptide binding]; other site
1064535005285	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1064535005286	Protein export membrane protein; Region: SecD_SecF; cl14618
1064535005287	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1064535005288	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1064535005289	Zn2+ binding site [ion binding]; other site
1064535005290	Mg2+ binding site [ion binding]; other site
1064535005291	AAA domain; Region: AAA_22; pfam13401
1064535005292	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1064535005293	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1064535005294	Int/Topo IB signature motif; other site
1064535005295	HD domain; Region: HD_3; cl17350
1064535005296	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1064535005297	classical (c) SDRs; Region: SDR_c; cd05233
1064535005298	NAD(P) binding site [chemical binding]; other site
1064535005299	active site
1064535005300	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
1064535005301	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1064535005302	homodimer interface [polypeptide binding]; other site
1064535005303	substrate-cofactor binding pocket; other site
1064535005304	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535005305	catalytic residue [active]
1064535005306	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
1064535005307	ArsC family; Region: ArsC; pfam03960
1064535005308	catalytic residue [active]
1064535005309	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1064535005310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1064535005311	putative substrate translocation pore; other site
1064535005312	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
1064535005313	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1064535005314	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1064535005315	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1064535005316	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1064535005317	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1064535005318	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1064535005319	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1064535005320	putative active site [active]
1064535005321	PhoH-like protein; Region: PhoH; pfam02562
1064535005322	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1064535005323	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1064535005324	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1064535005325	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
1064535005326	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1064535005327	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1064535005328	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
1064535005329	DNA binding site [nucleotide binding]
1064535005330	dimer interface [polypeptide binding]; other site
1064535005331	active site
1064535005332	Int/Topo IB signature motif; other site
1064535005333	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
1064535005334	LexA repressor; Validated; Region: PRK00215
1064535005335	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1064535005336	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1064535005337	Catalytic site [active]
1064535005338	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1064535005339	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1064535005340	ligand binding site [chemical binding]; other site
1064535005341	flexible hinge region; other site
1064535005342	putative switch regulator; other site
1064535005343	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1064535005344	non-specific DNA interactions [nucleotide binding]; other site
1064535005345	DNA binding site [nucleotide binding]
1064535005346	sequence specific DNA binding site [nucleotide binding]; other site
1064535005347	putative cAMP binding site [chemical binding]; other site
1064535005348	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1064535005349	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
1064535005350	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1064535005351	4Fe-4S binding domain; Region: Fer4; pfam00037
1064535005352	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
1064535005353	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
1064535005354	FAD binding pocket [chemical binding]; other site
1064535005355	FAD binding motif [chemical binding]; other site
1064535005356	phosphate binding motif [ion binding]; other site
1064535005357	beta-alpha-beta structure motif; other site
1064535005358	NAD binding pocket [chemical binding]; other site
1064535005359	Iron coordination center [ion binding]; other site
1064535005360	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
1064535005361	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
1064535005362	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1064535005363	CysD dimerization site [polypeptide binding]; other site
1064535005364	G1 box; other site
1064535005365	putative GEF interaction site [polypeptide binding]; other site
1064535005366	GTP/Mg2+ binding site [chemical binding]; other site
1064535005367	Switch I region; other site
1064535005368	G2 box; other site
1064535005369	G3 box; other site
1064535005370	Switch II region; other site
1064535005371	G4 box; other site
1064535005372	G5 box; other site
1064535005373	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1064535005374	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1064535005375	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1064535005376	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1064535005377	Active Sites [active]
1064535005378	Ferredoxin [Energy production and conversion]; Region: COG1146
1064535005379	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1064535005380	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
1064535005381	L-aspartate oxidase; Provisional; Region: PRK06175
1064535005382	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1064535005383	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1064535005384	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1064535005385	Walker A/P-loop; other site
1064535005386	ATP binding site [chemical binding]; other site
1064535005387	Q-loop/lid; other site
1064535005388	ABC transporter signature motif; other site
1064535005389	Walker B; other site
1064535005390	D-loop; other site
1064535005391	H-loop/switch region; other site
1064535005392	TOBE domain; Region: TOBE_2; pfam08402
1064535005393	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535005394	dimer interface [polypeptide binding]; other site
1064535005395	conserved gate region; other site
1064535005396	putative PBP binding loops; other site
1064535005397	ABC-ATPase subunit interface; other site
1064535005398	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1064535005399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535005400	dimer interface [polypeptide binding]; other site
1064535005401	conserved gate region; other site
1064535005402	putative PBP binding loops; other site
1064535005403	ABC-ATPase subunit interface; other site
1064535005404	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1064535005405	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1064535005406	membrane-bound complex binding site; other site
1064535005407	hinge residues; other site
1064535005408	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1064535005409	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1064535005410	dimer interface [polypeptide binding]; other site
1064535005411	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535005412	catalytic residue [active]
1064535005413	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1064535005414	Carbon starvation protein CstA; Region: CstA; pfam02554
1064535005415	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1064535005416	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1064535005417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535005418	active site
1064535005419	phosphorylation site [posttranslational modification]
1064535005420	intermolecular recognition site; other site
1064535005421	dimerization interface [polypeptide binding]; other site
1064535005422	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1064535005423	DNA binding residues [nucleotide binding]
1064535005424	dimerization interface [polypeptide binding]; other site
1064535005425	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1064535005426	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1064535005427	ATP binding site [chemical binding]; other site
1064535005428	Mg2+ binding site [ion binding]; other site
1064535005429	G-X-G motif; other site
1064535005430	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1064535005431	trimer interface [polypeptide binding]; other site
1064535005432	Haemagglutinin; Region: HIM; pfam05662
1064535005433	S-layer homology domain; Region: SLH; pfam00395
1064535005434	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1064535005435	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1064535005436	active site
1064535005437	metal binding site [ion binding]; metal-binding site
1064535005438	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1064535005439	Repair protein; Region: Repair_PSII; pfam04536
1064535005440	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
1064535005441	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1064535005442	Double zinc ribbon; Region: DZR; pfam12773
1064535005443	Peptidase family M48; Region: Peptidase_M48; cl12018
1064535005444	Right handed beta helix region; Region: Beta_helix; pfam13229
1064535005445	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1064535005446	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
1064535005447	active site
1064535005448	putative substrate binding pocket [chemical binding]; other site
1064535005449	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1064535005450	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1064535005451	homotetramer interface [polypeptide binding]; other site
1064535005452	ligand binding site [chemical binding]; other site
1064535005453	catalytic site [active]
1064535005454	NAD binding site [chemical binding]; other site
1064535005455	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1064535005456	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1064535005457	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1064535005458	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1064535005459	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1064535005460	dimerization interface [polypeptide binding]; other site
1064535005461	domain crossover interface; other site
1064535005462	redox-dependent activation switch; other site
1064535005463	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1064535005464	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1064535005465	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1064535005466	DNA binding site [nucleotide binding]
1064535005467	active site
1064535005468	Sulfatase; Region: Sulfatase; cl17466
1064535005469	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1064535005470	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1064535005471	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1064535005472	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1064535005473	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1064535005474	LDH/MDH dimer interface [polypeptide binding]; other site
1064535005475	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1064535005476	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1064535005477	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1064535005478	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1064535005479	Ligand binding site; other site
1064535005480	metal-binding site
1064535005481	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1064535005482	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1064535005483	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1064535005484	active site
1064535005485	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1064535005486	O-Antigen ligase; Region: Wzy_C; pfam04932
1064535005487	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1064535005488	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1064535005489	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1064535005490	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1064535005491	putative metal binding site; other site
1064535005492	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1064535005493	homopentamer interface [polypeptide binding]; other site
1064535005494	active site
1064535005495	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1064535005496	Lumazine binding domain; Region: Lum_binding; pfam00677
1064535005497	Lumazine binding domain; Region: Lum_binding; pfam00677
1064535005498	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1064535005499	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1064535005500	catalytic motif [active]
1064535005501	Zn binding site [ion binding]; other site
1064535005502	RibD C-terminal domain; Region: RibD_C; cl17279
1064535005503	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1064535005504	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1064535005505	substrate binding site [chemical binding]; other site
1064535005506	hexamer interface [polypeptide binding]; other site
1064535005507	metal binding site [ion binding]; metal-binding site
1064535005508	GTPase RsgA; Reviewed; Region: PRK00098
1064535005509	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1064535005510	RNA binding site [nucleotide binding]; other site
1064535005511	homodimer interface [polypeptide binding]; other site
1064535005512	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1064535005513	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1064535005514	GTP/Mg2+ binding site [chemical binding]; other site
1064535005515	G4 box; other site
1064535005516	G5 box; other site
1064535005517	G1 box; other site
1064535005518	Switch I region; other site
1064535005519	G2 box; other site
1064535005520	G3 box; other site
1064535005521	Switch II region; other site
1064535005522	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1064535005523	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1064535005524	active site
1064535005525	ATP binding site [chemical binding]; other site
1064535005526	substrate binding site [chemical binding]; other site
1064535005527	activation loop (A-loop); other site
1064535005528	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1064535005529	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1064535005530	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
1064535005531	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1064535005532	Protein phosphatase 2C; Region: PP2C; pfam00481
1064535005533	active site
1064535005534	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
1064535005535	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535005536	FeS/SAM binding site; other site
1064535005537	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1064535005538	NusB family; Region: NusB; pfam01029
1064535005539	putative RNA binding site [nucleotide binding]; other site
1064535005540	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535005541	S-adenosylmethionine binding site [chemical binding]; other site
1064535005542	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1064535005543	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1064535005544	putative active site [active]
1064535005545	substrate binding site [chemical binding]; other site
1064535005546	putative cosubstrate binding site; other site
1064535005547	catalytic site [active]
1064535005548	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1064535005549	substrate binding site [chemical binding]; other site
1064535005550	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1064535005551	active site
1064535005552	catalytic residues [active]
1064535005553	metal binding site [ion binding]; metal-binding site
1064535005554	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1064535005555	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1064535005556	ATP binding site [chemical binding]; other site
1064535005557	putative Mg++ binding site [ion binding]; other site
1064535005558	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1064535005559	nucleotide binding region [chemical binding]; other site
1064535005560	ATP-binding site [chemical binding]; other site
1064535005561	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1064535005562	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1064535005563	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1064535005564	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1064535005565	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1064535005566	Flavoprotein; Region: Flavoprotein; pfam02441
1064535005567	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1064535005568	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1064535005569	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1064535005570	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1064535005571	catalytic site [active]
1064535005572	G-X2-G-X-G-K; other site
1064535005573	hypothetical protein; Provisional; Region: PRK04323
1064535005574	hypothetical protein; Provisional; Region: PRK11820
1064535005575	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1064535005576	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1064535005577	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
1064535005578	CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562
1064535005579	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
1064535005580	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
1064535005581	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
1064535005582	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736
1064535005583	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
1064535005584	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1064535005585	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1064535005586	YibE/F-like protein; Region: YibE_F; pfam07907
1064535005587	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
1064535005588	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1064535005589	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
1064535005590	intersubunit interface [polypeptide binding]; other site
1064535005591	active site
1064535005592	Zn2+ binding site [ion binding]; other site
1064535005593	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
1064535005594	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1064535005595	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1064535005596	active site
1064535005597	metal binding site [ion binding]; metal-binding site
1064535005598	homotetramer interface [polypeptide binding]; other site
1064535005599	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1064535005600	active site
1064535005601	dimerization interface [polypeptide binding]; other site
1064535005602	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
1064535005603	glutamate racemase; Provisional; Region: PRK00865
1064535005604	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1064535005605	active site
1064535005606	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1064535005607	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
1064535005608	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1064535005609	classical (c) SDRs; Region: SDR_c; cd05233
1064535005610	NAD(P) binding site [chemical binding]; other site
1064535005611	active site
1064535005612	hypothetical protein; Provisional; Region: PRK10621
1064535005613	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1064535005614	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
1064535005615	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1064535005616	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1064535005617	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1064535005618	IHF dimer interface [polypeptide binding]; other site
1064535005619	IHF - DNA interface [nucleotide binding]; other site
1064535005620	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
1064535005621	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1064535005622	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1064535005623	homodimer interface [polypeptide binding]; other site
1064535005624	metal binding site [ion binding]; metal-binding site
1064535005625	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1064535005626	homodimer interface [polypeptide binding]; other site
1064535005627	active site
1064535005628	putative chemical substrate binding site [chemical binding]; other site
1064535005629	metal binding site [ion binding]; metal-binding site
1064535005630	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1064535005631	MarR family; Region: MarR_2; pfam12802
1064535005632	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1064535005633	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1064535005634	dimer interface [polypeptide binding]; other site
1064535005635	motif 1; other site
1064535005636	active site
1064535005637	motif 2; other site
1064535005638	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1064535005639	putative deacylase active site [active]
1064535005640	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1064535005641	active site
1064535005642	motif 3; other site
1064535005643	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1064535005644	anticodon binding site; other site
1064535005645	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1064535005646	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1064535005647	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1064535005648	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1064535005649	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1064535005650	active site
1064535005651	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1064535005652	protein binding site [polypeptide binding]; other site
1064535005653	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1064535005654	putative substrate binding region [chemical binding]; other site
1064535005655	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1064535005656	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1064535005657	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1064535005658	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1064535005659	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1064535005660	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1064535005661	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1064535005662	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1064535005663	catalytic residue [active]
1064535005664	putative FPP diphosphate  binding site; other site
1064535005665	putative FPP binding hydrophobic cleft; other site
1064535005666	dimer interface [polypeptide binding]; other site
1064535005667	putative IPP diphosphate binding site; other site
1064535005668	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1064535005669	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1064535005670	hinge region; other site
1064535005671	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1064535005672	putative nucleotide binding site [chemical binding]; other site
1064535005673	uridine monophosphate binding site [chemical binding]; other site
1064535005674	homohexameric interface [polypeptide binding]; other site
1064535005675	elongation factor Ts; Reviewed; Region: tsf; PRK12332
1064535005676	UBA/TS-N domain; Region: UBA; pfam00627
1064535005677	Elongation factor TS; Region: EF_TS; pfam00889
1064535005678	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1064535005679	rRNA interaction site [nucleotide binding]; other site
1064535005680	S8 interaction site; other site
1064535005681	putative laminin-1 binding site; other site
1064535005682	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1064535005683	G5 domain; Region: G5; pfam07501
1064535005684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1064535005685	polyphosphate kinase; Provisional; Region: PRK05443
1064535005686	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1064535005687	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1064535005688	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1064535005689	putative domain interface [polypeptide binding]; other site
1064535005690	putative active site [active]
1064535005691	catalytic site [active]
1064535005692	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1064535005693	putative domain interface [polypeptide binding]; other site
1064535005694	putative active site [active]
1064535005695	catalytic site [active]
1064535005696	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1064535005697	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1064535005698	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1064535005699	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1064535005700	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1064535005701	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
1064535005702	ferredoxin-type protein NapF; Region: napF; TIGR00402
1064535005703	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1064535005704	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1064535005705	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
1064535005706	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1064535005707	active site
1064535005708	catalytic tetrad [active]
1064535005709	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
1064535005710	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535005711	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1064535005712	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1064535005713	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
1064535005714	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1064535005715	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1064535005716	HlyD family secretion protein; Region: HlyD_3; pfam13437
1064535005717	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1064535005718	MarR family; Region: MarR_2; pfam12802
1064535005719	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1064535005720	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1064535005721	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1064535005722	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1064535005723	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1064535005724	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1064535005725	ATP binding site [chemical binding]; other site
1064535005726	putative Mg++ binding site [ion binding]; other site
1064535005727	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1064535005728	nucleotide binding region [chemical binding]; other site
1064535005729	ATP-binding site [chemical binding]; other site
1064535005730	TRCF domain; Region: TRCF; pfam03461
1064535005731	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1064535005732	amidase catalytic site [active]
1064535005733	Zn binding residues [ion binding]; other site
1064535005734	substrate binding site [chemical binding]; other site
1064535005735	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1064535005736	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1064535005737	active site
1064535005738	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1064535005739	glutamate dehydrogenase; Provisional; Region: PRK09414
1064535005740	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1064535005741	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1064535005742	NAD(P) binding site [chemical binding]; other site
1064535005743	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1064535005744	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1064535005745	amino acid transporter; Region: 2A0306; TIGR00909
1064535005746	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1064535005747	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1064535005748	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
1064535005749	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535005750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535005751	homodimer interface [polypeptide binding]; other site
1064535005752	catalytic residue [active]
1064535005753	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
1064535005754	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1064535005755	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
1064535005756	cobyric acid synthase; Provisional; Region: PRK00784
1064535005757	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1064535005758	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1064535005759	catalytic triad [active]
1064535005760	M48 family peptidase; Provisional; Region: PRK03001
1064535005761	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1064535005762	Peptidase family M50; Region: Peptidase_M50; pfam02163
1064535005763	active site
1064535005764	putative substrate binding region [chemical binding]; other site
1064535005765	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
1064535005766	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1064535005767	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1064535005768	Potassium binding sites [ion binding]; other site
1064535005769	Cesium cation binding sites [ion binding]; other site
1064535005770	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1064535005771	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1064535005772	active site
1064535005773	substrate binding site [chemical binding]; other site
1064535005774	metal binding site [ion binding]; metal-binding site
1064535005775	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1064535005776	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1064535005777	PYR/PP interface [polypeptide binding]; other site
1064535005778	dimer interface [polypeptide binding]; other site
1064535005779	TPP binding site [chemical binding]; other site
1064535005780	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1064535005781	transketolase; Reviewed; Region: PRK05899
1064535005782	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1064535005783	TPP-binding site [chemical binding]; other site
1064535005784	dimer interface [polypeptide binding]; other site
1064535005785	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535005786	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1064535005787	active site
1064535005788	motif I; other site
1064535005789	motif II; other site
1064535005790	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535005791	motif II; other site
1064535005792	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1064535005793	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1064535005794	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416
1064535005795	Rrf2 family protein; Region: rrf2_super; TIGR00738
1064535005796	Transcriptional regulator; Region: Rrf2; cl17282
1064535005797	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1064535005798	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1064535005799	G1 box; other site
1064535005800	putative GEF interaction site [polypeptide binding]; other site
1064535005801	GTP/Mg2+ binding site [chemical binding]; other site
1064535005802	Switch I region; other site
1064535005803	G2 box; other site
1064535005804	G3 box; other site
1064535005805	Switch II region; other site
1064535005806	G4 box; other site
1064535005807	G5 box; other site
1064535005808	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1064535005809	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1064535005810	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1064535005811	active site
1064535005812	metal binding site [ion binding]; metal-binding site
1064535005813	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1064535005814	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1064535005815	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1064535005816	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1064535005817	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1064535005818	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1064535005819	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1064535005820	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1064535005821	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1064535005822	substrate binding pocket [chemical binding]; other site
1064535005823	dimer interface [polypeptide binding]; other site
1064535005824	inhibitor binding site; inhibition site
1064535005825	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
1064535005826	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
1064535005827	B12 binding site [chemical binding]; other site
1064535005828	cobalt ligand [ion binding]; other site
1064535005829	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1064535005830	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1064535005831	catalytic loop [active]
1064535005832	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
1064535005833	iron binding site [ion binding]; other site
1064535005834	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1064535005835	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1064535005836	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1064535005837	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1064535005838	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1064535005839	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1064535005840	DNA binding residues [nucleotide binding]
1064535005841	DNA primase; Validated; Region: dnaG; PRK05667
1064535005842	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1064535005843	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1064535005844	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1064535005845	active site
1064535005846	metal binding site [ion binding]; metal-binding site
1064535005847	interdomain interaction site; other site
1064535005848	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1064535005849	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1064535005850	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1064535005851	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1064535005852	active site
1064535005853	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1064535005854	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1064535005855	intersubunit interface [polypeptide binding]; other site
1064535005856	active site
1064535005857	zinc binding site [ion binding]; other site
1064535005858	Na+ binding site [ion binding]; other site
1064535005859	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1064535005860	multidrug efflux protein; Reviewed; Region: PRK01766
1064535005861	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1064535005862	cation binding site [ion binding]; other site
1064535005863	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1064535005864	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1064535005865	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1064535005866	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1064535005867	Walker A/P-loop; other site
1064535005868	ATP binding site [chemical binding]; other site
1064535005869	Q-loop/lid; other site
1064535005870	ABC transporter signature motif; other site
1064535005871	Walker B; other site
1064535005872	D-loop; other site
1064535005873	H-loop/switch region; other site
1064535005874	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1064535005875	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535005876	dimer interface [polypeptide binding]; other site
1064535005877	conserved gate region; other site
1064535005878	ABC-ATPase subunit interface; other site
1064535005879	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1064535005880	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1064535005881	heterodimer interface [polypeptide binding]; other site
1064535005882	active site
1064535005883	FMN binding site [chemical binding]; other site
1064535005884	homodimer interface [polypeptide binding]; other site
1064535005885	substrate binding site [chemical binding]; other site
1064535005886	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
1064535005887	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1064535005888	FAD binding pocket [chemical binding]; other site
1064535005889	FAD binding motif [chemical binding]; other site
1064535005890	phosphate binding motif [ion binding]; other site
1064535005891	beta-alpha-beta structure motif; other site
1064535005892	NAD binding pocket [chemical binding]; other site
1064535005893	Iron coordination center [ion binding]; other site
1064535005894	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1064535005895	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1064535005896	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1064535005897	putative active site [active]
1064535005898	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1064535005899	GntP family permease; Region: GntP_permease; pfam02447
1064535005900	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1064535005901	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1064535005902	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1064535005903	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1064535005904	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1064535005905	N- and C-terminal domain interface [polypeptide binding]; other site
1064535005906	active site
1064535005907	catalytic site [active]
1064535005908	metal binding site [ion binding]; metal-binding site
1064535005909	carbohydrate binding site [chemical binding]; other site
1064535005910	ATP binding site [chemical binding]; other site
1064535005911	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1064535005912	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1064535005913	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1064535005914	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1064535005915	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1064535005916	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1064535005917	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1064535005918	domain interfaces; other site
1064535005919	active site
1064535005920	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1064535005921	active site
1064535005922	SAM binding site [chemical binding]; other site
1064535005923	homodimer interface [polypeptide binding]; other site
1064535005924	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1064535005925	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1064535005926	active site
1064535005927	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1064535005928	dimer interface [polypeptide binding]; other site
1064535005929	active site
1064535005930	Schiff base residues; other site
1064535005931	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1064535005932	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1064535005933	tRNA; other site
1064535005934	putative tRNA binding site [nucleotide binding]; other site
1064535005935	putative NADP binding site [chemical binding]; other site
1064535005936	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1064535005937	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1064535005938	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1064535005939	inhibitor-cofactor binding pocket; inhibition site
1064535005940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535005941	catalytic residue [active]
1064535005942	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1064535005943	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1064535005944	Walker A/P-loop; other site
1064535005945	ATP binding site [chemical binding]; other site
1064535005946	Q-loop/lid; other site
1064535005947	ABC transporter signature motif; other site
1064535005948	Walker B; other site
1064535005949	D-loop; other site
1064535005950	H-loop/switch region; other site
1064535005951	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1064535005952	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535005953	dimer interface [polypeptide binding]; other site
1064535005954	conserved gate region; other site
1064535005955	putative PBP binding loops; other site
1064535005956	ABC-ATPase subunit interface; other site
1064535005957	6-phosphofructokinase; Provisional; Region: PRK03202
1064535005958	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1064535005959	active site
1064535005960	ADP/pyrophosphate binding site [chemical binding]; other site
1064535005961	dimerization interface [polypeptide binding]; other site
1064535005962	allosteric effector site; other site
1064535005963	fructose-1,6-bisphosphate binding site; other site
1064535005964	shikimate kinase; Reviewed; Region: aroK; PRK00131
1064535005965	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1064535005966	ADP binding site [chemical binding]; other site
1064535005967	magnesium binding site [ion binding]; other site
1064535005968	putative shikimate binding site; other site
1064535005969	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
1064535005970	YadA-like C-terminal region; Region: YadA; pfam03895
1064535005971	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1064535005972	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1064535005973	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1064535005974	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1064535005975	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1064535005976	NADP binding site [chemical binding]; other site
1064535005977	active site
1064535005978	putative substrate binding site [chemical binding]; other site
1064535005979	Transposase; Region: HTH_Tnp_1; cl17663
1064535005980	putative transposase OrfB; Reviewed; Region: PHA02517
1064535005981	HTH-like domain; Region: HTH_21; pfam13276
1064535005982	Integrase core domain; Region: rve; pfam00665
1064535005983	Integrase core domain; Region: rve_3; pfam13683
1064535005984	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1064535005985	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1064535005986	NAD binding site [chemical binding]; other site
1064535005987	substrate binding site [chemical binding]; other site
1064535005988	homodimer interface [polypeptide binding]; other site
1064535005989	active site
1064535005990	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
1064535005991	four helix bundle protein; Region: TIGR02436
1064535005992	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1064535005993	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1064535005994	substrate binding site; other site
1064535005995	tetramer interface; other site
1064535005996	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1064535005997	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1064535005998	nucleotide binding pocket [chemical binding]; other site
1064535005999	K-X-D-G motif; other site
1064535006000	catalytic site [active]
1064535006001	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1064535006002	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1064535006003	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1064535006004	Part of AAA domain; Region: AAA_19; pfam13245
1064535006005	AAA domain; Region: AAA_14; pfam13173
1064535006006	Family description; Region: UvrD_C_2; pfam13538
1064535006007	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1064535006008	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1064535006009	DHH family; Region: DHH; pfam01368
1064535006010	DHHA2 domain; Region: DHHA2; pfam02833
1064535006011	biotin synthase; Region: bioB; TIGR00433
1064535006012	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535006013	FeS/SAM binding site; other site
1064535006014	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1064535006015	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1064535006016	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1064535006017	DALR anticodon binding domain; Region: DALR_1; pfam05746
1064535006018	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1064535006019	dimer interface [polypeptide binding]; other site
1064535006020	motif 1; other site
1064535006021	active site
1064535006022	motif 2; other site
1064535006023	motif 3; other site
1064535006024	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1064535006025	gamma subunit interface [polypeptide binding]; other site
1064535006026	epsilon subunit interface [polypeptide binding]; other site
1064535006027	LBP interface [polypeptide binding]; other site
1064535006028	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1064535006029	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1064535006030	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1064535006031	alpha subunit interaction interface [polypeptide binding]; other site
1064535006032	Walker A motif; other site
1064535006033	ATP binding site [chemical binding]; other site
1064535006034	Walker B motif; other site
1064535006035	inhibitor binding site; inhibition site
1064535006036	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1064535006037	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1064535006038	core domain interface [polypeptide binding]; other site
1064535006039	delta subunit interface [polypeptide binding]; other site
1064535006040	epsilon subunit interface [polypeptide binding]; other site
1064535006041	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1064535006042	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1064535006043	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1064535006044	beta subunit interaction interface [polypeptide binding]; other site
1064535006045	Walker A motif; other site
1064535006046	ATP binding site [chemical binding]; other site
1064535006047	Walker B motif; other site
1064535006048	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1064535006049	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1064535006050	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1064535006051	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1064535006052	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1064535006053	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1064535006054	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1064535006055	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1064535006056	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
1064535006057	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1064535006058	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1064535006059	active site
1064535006060	homodimer interface [polypeptide binding]; other site
1064535006061	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1064535006062	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1064535006063	Mg++ binding site [ion binding]; other site
1064535006064	putative catalytic motif [active]
1064535006065	substrate binding site [chemical binding]; other site
1064535006066	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1064535006067	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
1064535006068	phosphoglucomutase; Validated; Region: PRK07564
1064535006069	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1064535006070	active site
1064535006071	substrate binding site [chemical binding]; other site
1064535006072	metal binding site [ion binding]; metal-binding site
1064535006073	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1064535006074	active site
1064535006075	putative catalytic site [active]
1064535006076	DNA binding site [nucleotide binding]
1064535006077	putative phosphate binding site [ion binding]; other site
1064535006078	metal binding site A [ion binding]; metal-binding site
1064535006079	AP binding site [nucleotide binding]; other site
1064535006080	metal binding site B [ion binding]; metal-binding site
1064535006081	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1064535006082	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1064535006083	Yqey-like protein; Region: YqeY; pfam09424
1064535006084	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1064535006085	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535006086	FeS/SAM binding site; other site
1064535006087	HemN C-terminal domain; Region: HemN_C; pfam06969
1064535006088	GTP-binding protein LepA; Provisional; Region: PRK05433
1064535006089	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1064535006090	G1 box; other site
1064535006091	putative GEF interaction site [polypeptide binding]; other site
1064535006092	GTP/Mg2+ binding site [chemical binding]; other site
1064535006093	Switch I region; other site
1064535006094	G2 box; other site
1064535006095	G3 box; other site
1064535006096	Switch II region; other site
1064535006097	G4 box; other site
1064535006098	G5 box; other site
1064535006099	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1064535006100	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1064535006101	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1064535006102	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1064535006103	generic binding surface I; other site
1064535006104	generic binding surface II; other site
1064535006105	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1064535006106	PHP domain; Region: PHP; pfam02811
1064535006107	active site
1064535006108	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
1064535006109	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1064535006110	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1064535006111	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1064535006112	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1064535006113	catalytic residue [active]
1064535006114	gp58-like protein; Region: Gp58; pfam07902
1064535006115	Transposase; Region: HTH_Tnp_1; cl17663
1064535006116	putative transposase OrfB; Reviewed; Region: PHA02517
1064535006117	HTH-like domain; Region: HTH_21; pfam13276
1064535006118	Integrase core domain; Region: rve; pfam00665
1064535006119	Integrase core domain; Region: rve_3; pfam13683
1064535006120	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1064535006121	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1064535006122	protein-splicing catalytic site; other site
1064535006123	thioester formation/cholesterol transfer; other site
1064535006124	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
1064535006125	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1064535006126	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1064535006127	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1064535006128	catalytic residues [active]
1064535006129	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1064535006130	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
1064535006131	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1064535006132	DNA methylase; Region: N6_N4_Mtase; pfam01555
1064535006133	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1064535006134	trimer interface [polypeptide binding]; other site
1064535006135	active site
1064535006136	putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266
1064535006137	Transposase; Region: HTH_Tnp_1; cl17663
1064535006138	putative transposase OrfB; Reviewed; Region: PHA02517
1064535006139	HTH-like domain; Region: HTH_21; pfam13276
1064535006140	Integrase core domain; Region: rve; pfam00665
1064535006141	Integrase core domain; Region: rve_3; pfam13683
1064535006142	DNA primase; Provisional; Region: 61; PHA02540
1064535006143	CHC2 zinc finger; Region: zf-CHC2; cl17510
1064535006144	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1064535006145	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1064535006146	active site
1064535006147	metal binding site [ion binding]; metal-binding site
1064535006148	interdomain interaction site; other site
1064535006149	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
1064535006150	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1064535006151	Walker A motif; other site
1064535006152	ATP binding site [chemical binding]; other site
1064535006153	Walker B motif; other site
1064535006154	Helix-turn-helix domain; Region: HTH_36; pfam13730
1064535006155	Helix-turn-helix domain; Region: HTH_36; pfam13730
1064535006156	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1064535006157	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
1064535006158	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1064535006159	active site
1064535006160	DNA binding site [nucleotide binding]
1064535006161	Int/Topo IB signature motif; other site
1064535006162	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1064535006163	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1064535006164	Ligand Binding Site [chemical binding]; other site
1064535006165	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1064535006166	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1064535006167	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1064535006168	catalytic residue [active]
1064535006169	DNA topoisomerase III; Provisional; Region: PRK07726
1064535006170	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1064535006171	active site
1064535006172	putative interdomain interaction site [polypeptide binding]; other site
1064535006173	putative metal-binding site [ion binding]; other site
1064535006174	putative nucleotide binding site [chemical binding]; other site
1064535006175	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1064535006176	domain I; other site
1064535006177	DNA binding groove [nucleotide binding]
1064535006178	phosphate binding site [ion binding]; other site
1064535006179	domain II; other site
1064535006180	domain III; other site
1064535006181	nucleotide binding site [chemical binding]; other site
1064535006182	catalytic site [active]
1064535006183	domain IV; other site
1064535006184	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1064535006185	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535006186	AAA domain; Region: AAA_21; pfam13304
1064535006187	Walker A/P-loop; other site
1064535006188	ATP binding site [chemical binding]; other site
1064535006189	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1064535006190	putative active site [active]
1064535006191	putative metal-binding site [ion binding]; other site
1064535006192	putative bifunctional 4-alpha-glucanotransferase/glycogen debranching enzyme; Provisional; Region: PRK14510
1064535006193	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1064535006194	homodimer interface [polypeptide binding]; other site
1064535006195	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1064535006196	active site
1064535006197	homodimer interface [polypeptide binding]; other site
1064535006198	catalytic site [active]
1064535006199	4-alpha-glucanotransferase; Provisional; Region: PRK14508
1064535006200	glycogen synthase; Provisional; Region: glgA; PRK00654
1064535006201	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1064535006202	ADP-binding pocket [chemical binding]; other site
1064535006203	homodimer interface [polypeptide binding]; other site
1064535006204	glycogen branching enzyme; Provisional; Region: PRK12313
1064535006205	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1064535006206	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1064535006207	active site
1064535006208	catalytic site [active]
1064535006209	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1064535006210	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1064535006211	homodimer interface [polypeptide binding]; other site
1064535006212	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1064535006213	active site pocket [active]
1064535006214	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
1064535006215	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1064535006216	oligomer interface; other site
1064535006217	ligand binding site; other site
1064535006218	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1064535006219	dimer interface [polypeptide binding]; other site
1064535006220	N-terminal domain interface [polypeptide binding]; other site
1064535006221	sulfate 1 binding site; other site
1064535006222	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1064535006223	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1064535006224	ligand binding site; other site
1064535006225	oligomer interface; other site
1064535006226	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1064535006227	dimer interface [polypeptide binding]; other site
1064535006228	N-terminal domain interface [polypeptide binding]; other site
1064535006229	sulfate 1 binding site; other site
1064535006230	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1064535006231	Peptidase family U32; Region: Peptidase_U32; pfam01136
1064535006232	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1064535006233	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535006234	S-adenosylmethionine binding site [chemical binding]; other site
1064535006235	YceG-like family; Region: YceG; pfam02618
1064535006236	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1064535006237	dimerization interface [polypeptide binding]; other site
1064535006238	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
1064535006239	Predicted membrane protein [Function unknown]; Region: COG2860
1064535006240	UPF0126 domain; Region: UPF0126; pfam03458
1064535006241	UPF0126 domain; Region: UPF0126; pfam03458
1064535006242	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1064535006243	nucleoside/Zn binding site; other site
1064535006244	dimer interface [polypeptide binding]; other site
1064535006245	catalytic motif [active]
1064535006246	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1064535006247	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1064535006248	active site
1064535006249	tetramer interface; other site
1064535006250	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1064535006251	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1064535006252	UDP-galactopyranose mutase; Region: GLF; pfam03275
1064535006253	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1064535006254	putative active site pocket [active]
1064535006255	cleavage site
1064535006256	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1064535006257	trimer interface [polypeptide binding]; other site
1064535006258	active site
1064535006259	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1064535006260	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1064535006261	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1064535006262	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1064535006263	Ligand binding site [chemical binding]; other site
1064535006264	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1064535006265	Archaeal ATPase; Region: Arch_ATPase; pfam01637
1064535006266	AAA domain; Region: AAA_14; pfam13173
1064535006267	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
1064535006268	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1064535006269	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
1064535006270	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
1064535006271	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
1064535006272	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651
1064535006273	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
1064535006274	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1064535006275	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
1064535006276	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1064535006277	Sel1-like repeats; Region: SEL1; smart00671
1064535006278	Sel1 repeat; Region: Sel1; cl02723
1064535006279	Sel1-like repeats; Region: SEL1; smart00671
1064535006280	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1064535006281	Clp amino terminal domain; Region: Clp_N; pfam02861
1064535006282	Clp amino terminal domain; Region: Clp_N; pfam02861
1064535006283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535006284	Walker A motif; other site
1064535006285	ATP binding site [chemical binding]; other site
1064535006286	Walker B motif; other site
1064535006287	arginine finger; other site
1064535006288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535006289	Walker A motif; other site
1064535006290	ATP binding site [chemical binding]; other site
1064535006291	Walker B motif; other site
1064535006292	arginine finger; other site
1064535006293	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1064535006294	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
1064535006295	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1064535006296	Zn2+ binding site [ion binding]; other site
1064535006297	Mg2+ binding site [ion binding]; other site
1064535006298	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
1064535006299	EVE domain; Region: EVE; pfam01878
1064535006300	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1064535006301	AAA domain; Region: AAA_22; pfam13401
1064535006302	Walker A motif; other site
1064535006303	ATP binding site [chemical binding]; other site
1064535006304	Walker B motif; other site
1064535006305	arginine finger; other site
1064535006306	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
1064535006307	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1064535006308	putative metal binding site [ion binding]; other site
1064535006309	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1064535006310	Coenzyme A binding pocket [chemical binding]; other site
1064535006311	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1064535006312	transmembrane helices; other site
1064535006313	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1064535006314	Predicted membrane protein [Function unknown]; Region: COG2323
1064535006315	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
1064535006316	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1064535006317	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
1064535006318	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1064535006319	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1064535006320	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535006321	FeS/SAM binding site; other site
1064535006322	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1064535006323	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1064535006324	catalytic residues [active]
1064535006325	catalytic nucleophile [active]
1064535006326	Recombinase; Region: Recombinase; pfam07508
1064535006327	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1064535006328	Recombinase; Region: Recombinase; pfam07508
1064535006329	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1064535006330	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1064535006331	catalytic residues [active]
1064535006332	catalytic nucleophile [active]
1064535006333	Recombinase; Region: Recombinase; pfam07508
1064535006334	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1064535006335	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
1064535006336	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1064535006337	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535006338	S-adenosylmethionine binding site [chemical binding]; other site
1064535006339	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
1064535006340	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1064535006341	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1064535006342	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1064535006343	phosphopentomutase; Provisional; Region: PRK05362
1064535006344	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1064535006345	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1064535006346	dimer interface [polypeptide binding]; other site
1064535006347	ADP-ribose binding site [chemical binding]; other site
1064535006348	active site
1064535006349	nudix motif; other site
1064535006350	metal binding site [ion binding]; metal-binding site
1064535006351	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1064535006352	trimer interface [polypeptide binding]; other site
1064535006353	active site
1064535006354	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1064535006355	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1064535006356	RNase E interface [polypeptide binding]; other site
1064535006357	trimer interface [polypeptide binding]; other site
1064535006358	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1064535006359	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1064535006360	RNase E interface [polypeptide binding]; other site
1064535006361	trimer interface [polypeptide binding]; other site
1064535006362	active site
1064535006363	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1064535006364	putative nucleic acid binding region [nucleotide binding]; other site
1064535006365	G-X-X-G motif; other site
1064535006366	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1064535006367	RNA binding site [nucleotide binding]; other site
1064535006368	domain interface; other site
1064535006369	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1064535006370	16S/18S rRNA binding site [nucleotide binding]; other site
1064535006371	S13e-L30e interaction site [polypeptide binding]; other site
1064535006372	25S rRNA binding site [nucleotide binding]; other site
1064535006373	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
1064535006374	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1064535006375	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1064535006376	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1064535006377	arsenical-resistance protein; Region: acr3; TIGR00832
1064535006378	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
1064535006379	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1064535006380	P loop; other site
1064535006381	Nucleotide binding site [chemical binding]; other site
1064535006382	DTAP/Switch II; other site
1064535006383	Switch I; other site
1064535006384	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1064535006385	DTAP/Switch II; other site
1064535006386	Switch I; other site
1064535006387	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
1064535006388	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1064535006389	dimerization interface [polypeptide binding]; other site
1064535006390	putative DNA binding site [nucleotide binding]; other site
1064535006391	putative Zn2+ binding site [ion binding]; other site
1064535006392	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1064535006393	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1064535006394	dimer interface [polypeptide binding]; other site
1064535006395	anticodon binding site; other site
1064535006396	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1064535006397	homodimer interface [polypeptide binding]; other site
1064535006398	motif 1; other site
1064535006399	active site
1064535006400	motif 2; other site
1064535006401	GAD domain; Region: GAD; pfam02938
1064535006402	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1064535006403	motif 3; other site
1064535006404	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1064535006405	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1064535006406	dimer interface [polypeptide binding]; other site
1064535006407	motif 1; other site
1064535006408	active site
1064535006409	motif 2; other site
1064535006410	motif 3; other site
1064535006411	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1064535006412	anticodon binding site; other site
1064535006413	coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994
1064535006414	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535006415	FeS/SAM binding site; other site
1064535006416	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1064535006417	metal binding site 2 [ion binding]; metal-binding site
1064535006418	putative DNA binding helix; other site
1064535006419	metal binding site 1 [ion binding]; metal-binding site
1064535006420	dimer interface [polypeptide binding]; other site
1064535006421	structural Zn2+ binding site [ion binding]; other site
1064535006422	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1064535006423	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1064535006424	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1064535006425	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1064535006426	putative active site [active]
1064535006427	dimerization interface [polypeptide binding]; other site
1064535006428	putative tRNAtyr binding site [nucleotide binding]; other site
1064535006429	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1064535006430	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1064535006431	Zn2+ binding site [ion binding]; other site
1064535006432	Mg2+ binding site [ion binding]; other site
1064535006433	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1064535006434	synthetase active site [active]
1064535006435	NTP binding site [chemical binding]; other site
1064535006436	metal binding site [ion binding]; metal-binding site
1064535006437	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1064535006438	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1064535006439	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1064535006440	DHH family; Region: DHH; pfam01368
1064535006441	DHHA1 domain; Region: DHHA1; pfam02272
1064535006442	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1064535006443	EamA-like transporter family; Region: EamA; pfam00892
1064535006444	EamA-like transporter family; Region: EamA; pfam00892
1064535006445	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
1064535006446	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1064535006447	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1064535006448	dimer interface [polypeptide binding]; other site
1064535006449	PYR/PP interface [polypeptide binding]; other site
1064535006450	TPP binding site [chemical binding]; other site
1064535006451	substrate binding site [chemical binding]; other site
1064535006452	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1064535006453	Domain of unknown function; Region: EKR; pfam10371
1064535006454	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1064535006455	4Fe-4S binding domain; Region: Fer4; pfam00037
1064535006456	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1064535006457	TPP-binding site [chemical binding]; other site
1064535006458	dimer interface [polypeptide binding]; other site
1064535006459	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535006460	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535006461	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1064535006462	putative dimerization interface [polypeptide binding]; other site
1064535006463	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1064535006464	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1064535006465	motif II; other site
1064535006466	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1064535006467	propionate/acetate kinase; Provisional; Region: PRK12379
1064535006468	hypothetical protein; Provisional; Region: PRK13670
1064535006469	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1064535006470	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
1064535006471	heat shock protein 90; Provisional; Region: PRK05218
1064535006472	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1064535006473	ATP binding site [chemical binding]; other site
1064535006474	Mg2+ binding site [ion binding]; other site
1064535006475	G-X-G motif; other site
1064535006476	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1064535006477	Haemagglutinin; Region: HIM; pfam05662
1064535006478	S-layer homology domain; Region: SLH; pfam00395
1064535006479	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1064535006480	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1064535006481	active site
1064535006482	substrate-binding site [chemical binding]; other site
1064535006483	metal-binding site [ion binding]
1064535006484	ATP binding site [chemical binding]; other site
1064535006485	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
1064535006486	FOG: CBS domain [General function prediction only]; Region: COG0517
1064535006487	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1064535006488	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
1064535006489	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535006490	FeS/SAM binding site; other site
1064535006491	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1064535006492	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1064535006493	dimer interface [polypeptide binding]; other site
1064535006494	pyridoxal binding site [chemical binding]; other site
1064535006495	ATP binding site [chemical binding]; other site
1064535006496	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
1064535006497	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1064535006498	S1 domain; Region: S1_2; pfam13509
1064535006499	S1 domain; Region: S1_2; pfam13509
1064535006500	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
1064535006501	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1064535006502	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1064535006503	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1064535006504	Zn2+ binding site [ion binding]; other site
1064535006505	Mg2+ binding site [ion binding]; other site
1064535006506	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1064535006507	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1064535006508	active site
1064535006509	(T/H)XGH motif; other site
1064535006510	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1064535006511	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1064535006512	putative catalytic cysteine [active]
1064535006513	gamma-glutamyl kinase; Provisional; Region: PRK05429
1064535006514	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1064535006515	nucleotide binding site [chemical binding]; other site
1064535006516	homotetrameric interface [polypeptide binding]; other site
1064535006517	putative phosphate binding site [ion binding]; other site
1064535006518	putative allosteric binding site; other site
1064535006519	PUA domain; Region: PUA; pfam01472
1064535006520	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
1064535006521	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1064535006522	GTP1/OBG; Region: GTP1_OBG; pfam01018
1064535006523	Obg GTPase; Region: Obg; cd01898
1064535006524	G1 box; other site
1064535006525	GTP/Mg2+ binding site [chemical binding]; other site
1064535006526	Switch I region; other site
1064535006527	G2 box; other site
1064535006528	G3 box; other site
1064535006529	Switch II region; other site
1064535006530	G4 box; other site
1064535006531	G5 box; other site
1064535006532	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1064535006533	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1064535006534	C-terminal peptidase (prc); Region: prc; TIGR00225
1064535006535	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1064535006536	protein binding site [polypeptide binding]; other site
1064535006537	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1064535006538	Catalytic dyad [active]
1064535006539	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
1064535006540	Uncharacterized conserved protein [Function unknown]; Region: COG3334
1064535006541	Peptidase family M23; Region: Peptidase_M23; pfam01551
1064535006542	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1064535006543	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1064535006544	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1064535006545	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535006546	Walker A/P-loop; other site
1064535006547	ATP binding site [chemical binding]; other site
1064535006548	Q-loop/lid; other site
1064535006549	ABC transporter signature motif; other site
1064535006550	Walker B; other site
1064535006551	D-loop; other site
1064535006552	H-loop/switch region; other site
1064535006553	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1064535006554	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
1064535006555	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1064535006556	peptide chain release factor 2; Provisional; Region: PRK05589
1064535006557	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1064535006558	RF-1 domain; Region: RF-1; pfam00472
1064535006559	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1064535006560	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1064535006561	ATP binding site [chemical binding]; other site
1064535006562	putative Mg++ binding site [ion binding]; other site
1064535006563	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1064535006564	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1064535006565	nucleotide binding region [chemical binding]; other site
1064535006566	ATP-binding site [chemical binding]; other site
1064535006567	Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340
1064535006568	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1064535006569	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1064535006570	Na binding site [ion binding]; other site
1064535006571	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1064535006572	30S subunit binding site; other site
1064535006573	S-layer homology domain; Region: SLH; pfam00395
1064535006574	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
1064535006575	Transposase; Region: HTH_Tnp_1; cl17663
1064535006576	putative transposase OrfB; Reviewed; Region: PHA02517
1064535006577	HTH-like domain; Region: HTH_21; pfam13276
1064535006578	Integrase core domain; Region: rve; pfam00665
1064535006579	Integrase core domain; Region: rve_3; pfam13683
1064535006580	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
1064535006581	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1064535006582	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1064535006583	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1064535006584	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1064535006585	putative substrate binding site [chemical binding]; other site
1064535006586	putative ATP binding site [chemical binding]; other site
1064535006587	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1064535006588	aspartate kinase; Reviewed; Region: PRK06635
1064535006589	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
1064535006590	putative catalytic residues [active]
1064535006591	putative nucleotide binding site [chemical binding]; other site
1064535006592	putative aspartate binding site [chemical binding]; other site
1064535006593	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1064535006594	putative allosteric regulatory site; other site
1064535006595	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
1064535006596	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1064535006597	thiamine phosphate binding site [chemical binding]; other site
1064535006598	active site
1064535006599	pyrophosphate binding site [ion binding]; other site
1064535006600	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1064535006601	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1064535006602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1064535006603	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1064535006604	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1064535006605	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1064535006606	Family of unknown function (DUF633); Region: DUF633; pfam04816
1064535006607	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1064535006608	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1064535006609	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1064535006610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1064535006611	active site
1064535006612	phosphorylation site [posttranslational modification]
1064535006613	intermolecular recognition site; other site
1064535006614	dimerization interface [polypeptide binding]; other site
1064535006615	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1064535006616	DNA binding site [nucleotide binding]
1064535006617	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1064535006618	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1064535006619	dimerization interface [polypeptide binding]; other site
1064535006620	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1064535006621	dimer interface [polypeptide binding]; other site
1064535006622	phosphorylation site [posttranslational modification]
1064535006623	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1064535006624	ATP binding site [chemical binding]; other site
1064535006625	Mg2+ binding site [ion binding]; other site
1064535006626	G-X-G motif; other site
1064535006627	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1064535006628	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
1064535006629	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1064535006630	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1064535006631	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
1064535006632	Recombination protein O N terminal; Region: RecO_N; pfam11967
1064535006633	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1064535006634	Domain of unknown function DUF21; Region: DUF21; pfam01595
1064535006635	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1064535006636	Transporter associated domain; Region: CorC_HlyC; smart01091
1064535006637	GTPase Era; Reviewed; Region: era; PRK00089
1064535006638	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1064535006639	G1 box; other site
1064535006640	GTP/Mg2+ binding site [chemical binding]; other site
1064535006641	Switch I region; other site
1064535006642	G2 box; other site
1064535006643	Switch II region; other site
1064535006644	G3 box; other site
1064535006645	G4 box; other site
1064535006646	G5 box; other site
1064535006647	KH domain; Region: KH_2; pfam07650
1064535006648	metal-binding heat shock protein; Provisional; Region: PRK00016
1064535006649	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1064535006650	PhoH-like protein; Region: PhoH; pfam02562
1064535006651	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1064535006652	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
1064535006653	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1064535006654	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535006655	FeS/SAM binding site; other site
1064535006656	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
1064535006657	NAD synthetase; Provisional; Region: PRK13981
1064535006658	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1064535006659	multimer interface [polypeptide binding]; other site
1064535006660	active site
1064535006661	catalytic triad [active]
1064535006662	protein interface 1 [polypeptide binding]; other site
1064535006663	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1064535006664	Ligand Binding Site [chemical binding]; other site
1064535006665	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1064535006666	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1064535006667	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1064535006668	HlyD family secretion protein; Region: HlyD_3; pfam13437
1064535006669	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1064535006670	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1064535006671	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
1064535006672	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1064535006673	substrate binding site [chemical binding]; other site
1064535006674	multimerization interface [polypeptide binding]; other site
1064535006675	ATP binding site [chemical binding]; other site
1064535006676	Domain of unknown function (DUF386); Region: DUF386; cl01047
1064535006677	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1064535006678	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1064535006679	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1064535006680	P loop; other site
1064535006681	GTP binding site [chemical binding]; other site
1064535006682	AAA domain; Region: AAA_23; pfam13476
1064535006683	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1064535006684	Walker A/P-loop; other site
1064535006685	ATP binding site [chemical binding]; other site
1064535006686	Q-loop/lid; other site
1064535006687	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1064535006688	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1064535006689	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1064535006690	Q-loop/lid; other site
1064535006691	ABC transporter signature motif; other site
1064535006692	Walker B; other site
1064535006693	D-loop; other site
1064535006694	H-loop/switch region; other site
1064535006695	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1064535006696	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1064535006697	Cl binding site [ion binding]; other site
1064535006698	oligomer interface [polypeptide binding]; other site
1064535006699	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1064535006700	RNA/DNA hybrid binding site [nucleotide binding]; other site
1064535006701	active site
1064535006702	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1064535006703	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1064535006704	GTP/Mg2+ binding site [chemical binding]; other site
1064535006705	G4 box; other site
1064535006706	G5 box; other site
1064535006707	G1 box; other site
1064535006708	Switch I region; other site
1064535006709	G2 box; other site
1064535006710	G3 box; other site
1064535006711	Switch II region; other site
1064535006712	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1064535006713	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1064535006714	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1064535006715	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1064535006716	active site
1064535006717	dimer interface [polypeptide binding]; other site
1064535006718	motif 1; other site
1064535006719	motif 2; other site
1064535006720	motif 3; other site
1064535006721	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1064535006722	anticodon binding site; other site
1064535006723	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1064535006724	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1064535006725	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1064535006726	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1064535006727	Ligand binding site [chemical binding]; other site
1064535006728	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1064535006729	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1064535006730	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1064535006731	FAD binding site [chemical binding]; other site
1064535006732	homotetramer interface [polypeptide binding]; other site
1064535006733	substrate binding pocket [chemical binding]; other site
1064535006734	catalytic base [active]
1064535006735	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1064535006736	putative active site [active]
1064535006737	putative CoA binding site [chemical binding]; other site
1064535006738	nudix motif; other site
1064535006739	metal binding site [ion binding]; metal-binding site
1064535006740	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1064535006741	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1064535006742	HIGH motif; other site
1064535006743	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1064535006744	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1064535006745	active site
1064535006746	KMSKS motif; other site
1064535006747	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1064535006748	tRNA binding surface [nucleotide binding]; other site
1064535006749	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1064535006750	active site
1064535006751	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1064535006752	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
1064535006753	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1064535006754	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1064535006755	trimerization site [polypeptide binding]; other site
1064535006756	active site
1064535006757	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1064535006758	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1064535006759	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1064535006760	catalytic residue [active]
1064535006761	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1064535006762	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1064535006763	FeS assembly protein SufB; Region: sufB; TIGR01980
1064535006764	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1064535006765	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1064535006766	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1064535006767	Walker A/P-loop; other site
1064535006768	ATP binding site [chemical binding]; other site
1064535006769	Q-loop/lid; other site
1064535006770	ABC transporter signature motif; other site
1064535006771	Walker B; other site
1064535006772	D-loop; other site
1064535006773	H-loop/switch region; other site
1064535006774	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
1064535006775	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535006776	FeS/SAM binding site; other site
1064535006777	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1064535006778	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
1064535006779	Rubredoxin [Energy production and conversion]; Region: COG1773
1064535006780	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1064535006781	iron binding site [ion binding]; other site
1064535006782	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1064535006783	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1064535006784	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1064535006785	GIY-YIG motif/motif A; other site
1064535006786	active site
1064535006787	catalytic site [active]
1064535006788	putative DNA binding site [nucleotide binding]; other site
1064535006789	metal binding site [ion binding]; metal-binding site
1064535006790	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1064535006791	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1064535006792	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1064535006793	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1064535006794	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1064535006795	excinuclease ABC subunit B; Provisional; Region: PRK05298
1064535006796	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1064535006797	ATP binding site [chemical binding]; other site
1064535006798	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1064535006799	nucleotide binding region [chemical binding]; other site
1064535006800	ATP-binding site [chemical binding]; other site
1064535006801	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1064535006802	UvrB/uvrC motif; Region: UVR; pfam02151
1064535006803	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
1064535006804	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1064535006805	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1064535006806	putative active site [active]
1064535006807	putative metal binding site [ion binding]; other site
1064535006808	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1064535006809	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1064535006810	minor groove reading motif; other site
1064535006811	helix-hairpin-helix signature motif; other site
1064535006812	substrate binding pocket [chemical binding]; other site
1064535006813	active site
1064535006814	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1064535006815	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1064535006816	DNA binding and oxoG recognition site [nucleotide binding]
1064535006817	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535006818	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
1064535006819	Probable transposase; Region: OrfB_IS605; pfam01385
1064535006820	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535006821	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
1064535006822	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1064535006823	dimerization interface [polypeptide binding]; other site
1064535006824	active site
1064535006825	L-aspartate oxidase; Provisional; Region: PRK06175
1064535006826	FAD binding domain; Region: FAD_binding_2; pfam00890
1064535006827	Quinolinate synthetase A protein; Region: NadA; pfam02445
1064535006828	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1064535006829	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1064535006830	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1064535006831	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1064535006832	active site
1064535006833	catalytic site [active]
1064535006834	metal binding site [ion binding]; metal-binding site
1064535006835	dimer interface [polypeptide binding]; other site
1064535006836	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1064535006837	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1064535006838	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1064535006839	putative NAD(P) binding site [chemical binding]; other site
1064535006840	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1064535006841	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1064535006842	NAD binding site [chemical binding]; other site
1064535006843	catalytic residues [active]
1064535006844	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1064535006845	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1064535006846	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1064535006847	minor groove reading motif; other site
1064535006848	helix-hairpin-helix signature motif; other site
1064535006849	substrate binding pocket [chemical binding]; other site
1064535006850	active site
1064535006851	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1064535006852	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
1064535006853	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
1064535006854	Ligand Binding Site [chemical binding]; other site
1064535006855	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
1064535006856	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1064535006857	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1064535006858	active site
1064535006859	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1064535006860	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1064535006861	PYR/PP interface [polypeptide binding]; other site
1064535006862	dimer interface [polypeptide binding]; other site
1064535006863	TPP binding site [chemical binding]; other site
1064535006864	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1064535006865	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1064535006866	transketolase; Reviewed; Region: PRK05899
1064535006867	TPP-binding site [chemical binding]; other site
1064535006868	dimer interface [polypeptide binding]; other site
1064535006869	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1064535006870	oligomerization interface [polypeptide binding]; other site
1064535006871	active site
1064535006872	metal binding site [ion binding]; metal-binding site
1064535006873	Uncharacterized conserved protein [Function unknown]; Region: COG5495
1064535006874	Rossmann-like domain; Region: Rossmann-like; pfam10727
1064535006875	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1064535006876	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1064535006877	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1064535006878	putative active site [active]
1064535006879	putative NTP binding site [chemical binding]; other site
1064535006880	putative nucleic acid binding site [nucleotide binding]; other site
1064535006881	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1064535006882	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1064535006883	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1064535006884	active site
1064535006885	HIGH motif; other site
1064535006886	nucleotide binding site [chemical binding]; other site
1064535006887	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1064535006888	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1064535006889	active site
1064535006890	KMSKS motif; other site
1064535006891	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1064535006892	tRNA binding surface [nucleotide binding]; other site
1064535006893	anticodon binding site; other site
1064535006894	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1064535006895	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1064535006896	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1064535006897	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1064535006898	Zn2+ binding site [ion binding]; other site
1064535006899	Mg2+ binding site [ion binding]; other site
1064535006900	NAD-dependent deacetylase; Provisional; Region: PRK00481
1064535006901	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1064535006902	S-layer homology domain; Region: SLH; pfam00395
1064535006903	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
1064535006904	putative ADP-ribose binding site [chemical binding]; other site
1064535006905	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
1064535006906	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1064535006907	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1064535006908	NAD binding site [chemical binding]; other site
1064535006909	substrate binding site [chemical binding]; other site
1064535006910	putative active site [active]
1064535006911	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1064535006912	MutS domain III; Region: MutS_III; pfam05192
1064535006913	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1064535006914	Walker A/P-loop; other site
1064535006915	ATP binding site [chemical binding]; other site
1064535006916	Q-loop/lid; other site
1064535006917	ABC transporter signature motif; other site
1064535006918	Walker B; other site
1064535006919	D-loop; other site
1064535006920	H-loop/switch region; other site
1064535006921	Smr domain; Region: Smr; pfam01713
1064535006922	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1064535006923	Peptidase family U32; Region: Peptidase_U32; pfam01136
1064535006924	Collagenase; Region: DUF3656; pfam12392
1064535006925	Peptidase family U32; Region: Peptidase_U32; pfam01136
1064535006926	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1064535006927	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1064535006928	active site
1064535006929	NAD binding site [chemical binding]; other site
1064535006930	metal binding site [ion binding]; metal-binding site
1064535006931	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1064535006932	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1064535006933	23S rRNA interface [nucleotide binding]; other site
1064535006934	L3 interface [polypeptide binding]; other site
1064535006935	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1064535006936	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1064535006937	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1064535006938	dimerization interface [polypeptide binding]; other site
1064535006939	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1064535006940	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1064535006941	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1064535006942	catalytic residue [active]
1064535006943	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
1064535006944	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
1064535006945	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1064535006946	homodimer interface [polypeptide binding]; other site
1064535006947	substrate-cofactor binding pocket; other site
1064535006948	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535006949	catalytic residue [active]
1064535006950	Homoserine O-succinyltransferase; Region: HTS; pfam04204
1064535006951	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1064535006952	proposed active site lysine [active]
1064535006953	conserved cys residue [active]
1064535006954	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1064535006955	active site
1064535006956	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
1064535006957	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1064535006958	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1064535006959	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1064535006960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1064535006961	S-adenosylmethionine binding site [chemical binding]; other site
1064535006962	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1064535006963	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1064535006964	RF-1 domain; Region: RF-1; pfam00472
1064535006965	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
1064535006966	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1064535006967	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
1064535006968	ThiS-like ubiquitin; Region: ThiS-like; pfam14453
1064535006969	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
1064535006970	E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487
1064535006971	putative ATP binding site [chemical binding]; other site
1064535006972	putative substrate interface [chemical binding]; other site
1064535006973	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1064535006974	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1064535006975	FeS/SAM binding site; other site
1064535006976	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1064535006977	ATP cone domain; Region: ATP-cone; pfam03477
1064535006978	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1064535006979	effector binding site; other site
1064535006980	active site
1064535006981	Zn binding site [ion binding]; other site
1064535006982	glycine loop; other site
1064535006983	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1064535006984	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1064535006985	putative ATP binding site [chemical binding]; other site
1064535006986	putative substrate interface [chemical binding]; other site
1064535006987	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1064535006988	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1064535006989	dimer interface [polypeptide binding]; other site
1064535006990	active site
1064535006991	metal binding site [ion binding]; metal-binding site
1064535006992	glutathione binding site [chemical binding]; other site
1064535006993	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1064535006994	putative deacylase active site [active]
1064535006995	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1064535006996	AAA domain; Region: AAA_23; pfam13476
1064535006997	Walker A/P-loop; other site
1064535006998	ATP binding site [chemical binding]; other site
1064535006999	Q-loop/lid; other site
1064535007000	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1064535007001	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1064535007002	ABC transporter signature motif; other site
1064535007003	Walker B; other site
1064535007004	D-loop; other site
1064535007005	H-loop/switch region; other site
1064535007006	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1064535007007	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1064535007008	active site
1064535007009	metal binding site [ion binding]; metal-binding site
1064535007010	DNA binding site [nucleotide binding]
1064535007011	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1064535007012	endonuclease IV; Provisional; Region: PRK01060
1064535007013	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1064535007014	AP (apurinic/apyrimidinic) site pocket; other site
1064535007015	DNA interaction; other site
1064535007016	Metal-binding active site; metal-binding site
1064535007017	ferric uptake regulator; Provisional; Region: fur; PRK09462
1064535007018	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1064535007019	metal binding site 2 [ion binding]; metal-binding site
1064535007020	putative DNA binding helix; other site
1064535007021	metal binding site 1 [ion binding]; metal-binding site
1064535007022	dimer interface [polypeptide binding]; other site
1064535007023	structural Zn2+ binding site [ion binding]; other site
1064535007024	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1064535007025	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1064535007026	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1064535007027	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1064535007028	RNA binding site [nucleotide binding]; other site
1064535007029	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1064535007030	Double zinc ribbon; Region: DZR; pfam12773
1064535007031	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1064535007032	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1064535007033	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1064535007034	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
1064535007035	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1064535007036	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1064535007037	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1064535007038	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1064535007039	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1064535007040	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1064535007041	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1064535007042	Probable transposase; Region: OrfB_IS605; pfam01385
1064535007043	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1064535007044	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
1064535007045	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1064535007046	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1064535007047	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
1064535007048	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1064535007049	FAD binding domain; Region: FAD_binding_4; pfam01565
1064535007050	L-lactate permease; Region: Lactate_perm; cl00701
1064535007051	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1064535007052	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1064535007053	pyrroline-5-carboxylate reductase; Region: PLN02688
1064535007054	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1064535007055	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1064535007056	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1064535007057	homodimer interface [polypeptide binding]; other site
1064535007058	catalytic residue [active]
1064535007059	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1064535007060	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1064535007061	substrate binding pocket [chemical binding]; other site
1064535007062	membrane-bound complex binding site; other site
1064535007063	hinge residues; other site
1064535007064	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1064535007065	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1064535007066	Walker A/P-loop; other site
1064535007067	ATP binding site [chemical binding]; other site
1064535007068	Q-loop/lid; other site
1064535007069	ABC transporter signature motif; other site
1064535007070	Walker B; other site
1064535007071	D-loop; other site
1064535007072	H-loop/switch region; other site
1064535007073	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1064535007074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1064535007075	dimer interface [polypeptide binding]; other site
1064535007076	conserved gate region; other site
1064535007077	putative PBP binding loops; other site
1064535007078	ABC-ATPase subunit interface; other site