-- dump date 20140619_140500 -- class Genbank::misc_feature -- table misc_feature_note -- id note 526227000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 526227000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 526227000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227000004 Walker A motif; other site 526227000005 ATP binding site [chemical binding]; other site 526227000006 Walker B motif; other site 526227000007 arginine finger; other site 526227000008 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 526227000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 526227000010 DnaA box-binding interface [nucleotide binding]; other site 526227000011 DNA polymerase III subunit beta; Provisional; Region: PRK14945 526227000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 526227000013 putative DNA binding surface [nucleotide binding]; other site 526227000014 dimer interface [polypeptide binding]; other site 526227000015 beta-clamp/clamp loader binding surface; other site 526227000016 beta-clamp/translesion DNA polymerase binding surface; other site 526227000017 enolase; Provisional; Region: eno; PRK00077 526227000018 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 526227000019 dimer interface [polypeptide binding]; other site 526227000020 metal binding site [ion binding]; metal-binding site 526227000021 substrate binding pocket [chemical binding]; other site 526227000022 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 526227000023 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 526227000024 domain interfaces; other site 526227000025 active site 526227000026 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526227000027 Cytochrome P450; Region: p450; cl12078 526227000028 putative transposase OrfB; Reviewed; Region: PHA02517 526227000029 Integrase core domain; Region: rve; pfam00665 526227000030 Integrase core domain; Region: rve_3; pfam13683 526227000031 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227000032 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227000033 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 526227000034 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227000035 MULE transposase domain; Region: MULE; pfam10551 526227000036 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 526227000037 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 526227000038 Nitrogen regulatory protein P-II; Region: P-II; smart00938 526227000039 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 526227000040 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 526227000041 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 526227000042 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 526227000043 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 526227000044 substrate binding pocket [chemical binding]; other site 526227000045 chain length determination region; other site 526227000046 substrate-Mg2+ binding site; other site 526227000047 catalytic residues [active] 526227000048 aspartate-rich region 1; other site 526227000049 active site lid residues [active] 526227000050 aspartate-rich region 2; other site 526227000051 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 526227000052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227000053 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227000054 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 526227000055 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 526227000056 TPP-binding site; other site 526227000057 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 526227000058 PYR/PP interface [polypeptide binding]; other site 526227000059 dimer interface [polypeptide binding]; other site 526227000060 TPP binding site [chemical binding]; other site 526227000061 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526227000062 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526227000063 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 526227000064 Putative zinc ribbon domain; Region: DUF164; pfam02591 526227000065 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526227000066 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 526227000067 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 526227000068 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 526227000069 active site 526227000070 tetramer interface [polypeptide binding]; other site 526227000071 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 526227000072 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526227000073 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 526227000074 putative active site [active] 526227000075 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 526227000076 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 526227000077 putative [4Fe-4S] binding site [ion binding]; other site 526227000078 putative molybdopterin cofactor binding site [chemical binding]; other site 526227000079 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 526227000080 putative molybdopterin cofactor binding site; other site 526227000081 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 526227000082 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 526227000083 metal binding site [ion binding]; metal-binding site 526227000084 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 526227000085 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526227000086 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227000087 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 526227000088 Walker A/P-loop; other site 526227000089 ATP binding site [chemical binding]; other site 526227000090 Q-loop/lid; other site 526227000091 ABC transporter signature motif; other site 526227000092 Walker B; other site 526227000093 D-loop; other site 526227000094 H-loop/switch region; other site 526227000095 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227000096 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526227000097 TM-ABC transporter signature motif; other site 526227000098 D-allose transporter subunit; Provisional; Region: PRK09701 526227000099 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227000100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227000101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227000102 DNA binding site [nucleotide binding] 526227000103 domain linker motif; other site 526227000104 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227000105 dimerization interface [polypeptide binding]; other site 526227000106 ligand binding site [chemical binding]; other site 526227000107 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 526227000108 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 526227000109 homodimer interface [polypeptide binding]; other site 526227000110 substrate-cofactor binding pocket; other site 526227000111 catalytic residue [active] 526227000112 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 526227000113 ATP cone domain; Region: ATP-cone; pfam03477 526227000114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227000115 NAD(P) binding site [chemical binding]; other site 526227000116 active site 526227000117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227000118 S-adenosylmethionine binding site [chemical binding]; other site 526227000119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227000120 Coenzyme A binding pocket [chemical binding]; other site 526227000121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 526227000122 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 526227000123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227000124 Coenzyme A binding pocket [chemical binding]; other site 526227000125 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227000126 active site 526227000127 metal binding site [ion binding]; metal-binding site 526227000128 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 526227000129 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 526227000130 putative ADP-ribose binding site [chemical binding]; other site 526227000131 recombination protein F; Provisional; Region: recF; PRK14079 526227000132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227000133 Walker A/P-loop; other site 526227000134 ATP binding site [chemical binding]; other site 526227000135 Q-loop/lid; other site 526227000136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227000137 ABC transporter signature motif; other site 526227000138 Walker B; other site 526227000139 D-loop; other site 526227000140 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 526227000141 Protein of unknown function (DUF721); Region: DUF721; pfam05258 526227000142 Protein of unknown function DUF45; Region: DUF45; pfam01863 526227000143 Helix-turn-helix domain; Region: HTH_17; pfam12728 526227000144 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 526227000145 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 526227000146 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 526227000147 short chain dehydrogenase; Provisional; Region: PRK12827 526227000148 classical (c) SDRs; Region: SDR_c; cd05233 526227000149 NAD(P) binding site [chemical binding]; other site 526227000150 active site 526227000151 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227000152 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526227000153 active site 526227000154 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 526227000155 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 526227000156 SnoaL-like domain; Region: SnoaL_2; pfam12680 526227000157 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526227000158 GAF domain; Region: GAF; pfam01590 526227000159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526227000160 Histidine kinase; Region: HisKA_3; pfam07730 526227000161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227000162 ATP binding site [chemical binding]; other site 526227000163 Mg2+ binding site [ion binding]; other site 526227000164 G-X-G motif; other site 526227000165 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227000166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227000167 active site 526227000168 phosphorylation site [posttranslational modification] 526227000169 intermolecular recognition site; other site 526227000170 dimerization interface [polypeptide binding]; other site 526227000171 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227000172 DNA binding residues [nucleotide binding] 526227000173 dimerization interface [polypeptide binding]; other site 526227000174 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 526227000175 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 526227000176 RNA binding site [nucleotide binding]; other site 526227000177 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526227000178 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227000179 active site 526227000180 Protein of unknown function (DUF692); Region: DUF692; cl01263 526227000181 threonine dehydratase; Provisional; Region: PRK08198 526227000182 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 526227000183 tetramer interface [polypeptide binding]; other site 526227000184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227000185 catalytic residue [active] 526227000186 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 526227000187 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 526227000188 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 526227000189 dimer interface [polypeptide binding]; other site 526227000190 putative functional site; other site 526227000191 putative MPT binding site; other site 526227000192 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 526227000193 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 526227000194 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526227000195 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526227000196 active site 526227000197 catalytic tetrad [active] 526227000198 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 526227000199 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 526227000200 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 526227000201 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 526227000202 VanW like protein; Region: VanW; pfam04294 526227000203 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 526227000204 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 526227000205 metal binding site [ion binding]; metal-binding site 526227000206 dimer interface [polypeptide binding]; other site 526227000207 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 526227000208 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 526227000209 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227000210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227000211 dimer interface [polypeptide binding]; other site 526227000212 conserved gate region; other site 526227000213 putative PBP binding loops; other site 526227000214 ABC-ATPase subunit interface; other site 526227000215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526227000216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227000217 putative PBP binding loops; other site 526227000218 dimer interface [polypeptide binding]; other site 526227000219 ABC-ATPase subunit interface; other site 526227000220 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 526227000221 classical (c) SDRs; Region: SDR_c; cd05233 526227000222 NAD(P) binding site [chemical binding]; other site 526227000223 active site 526227000224 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 526227000225 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 526227000226 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227000227 active site residue [active] 526227000228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526227000229 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526227000230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 526227000231 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 526227000232 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 526227000233 Peptidase S8 family domain, uncharacterized subfamily 5; Region: Peptidases_S8_5; cd07489 526227000234 active site 526227000235 catalytic triad [active] 526227000236 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 526227000237 PA/protease or protease-like domain interface [polypeptide binding]; other site 526227000238 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227000239 catalytic residues [active] 526227000240 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 526227000241 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526227000242 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227000243 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526227000244 putative transposase OrfB; Reviewed; Region: PHA02517 526227000245 Integrase core domain; Region: rve; pfam00665 526227000246 Integrase core domain; Region: rve_3; pfam13683 526227000247 prolyl-tRNA synthetase; Provisional; Region: PRK08661 526227000248 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 526227000249 dimer interface [polypeptide binding]; other site 526227000250 motif 1; other site 526227000251 active site 526227000252 motif 2; other site 526227000253 motif 3; other site 526227000254 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 526227000255 anticodon binding site; other site 526227000256 zinc-binding site [ion binding]; other site 526227000257 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227000258 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526227000259 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526227000260 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 526227000261 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 526227000262 minor groove reading motif; other site 526227000263 helix-hairpin-helix signature motif; other site 526227000264 substrate binding pocket [chemical binding]; other site 526227000265 active site 526227000266 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 526227000267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227000268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227000269 putative substrate translocation pore; other site 526227000270 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 526227000271 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 526227000272 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 526227000273 dimer interface [polypeptide binding]; other site 526227000274 acyl-activating enzyme (AAE) consensus motif; other site 526227000275 putative active site [active] 526227000276 AMP binding site [chemical binding]; other site 526227000277 putative CoA binding site [chemical binding]; other site 526227000278 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 526227000279 active site 526227000280 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 526227000281 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 526227000282 folate binding site [chemical binding]; other site 526227000283 NADP+ binding site [chemical binding]; other site 526227000284 thymidylate synthase; Reviewed; Region: thyA; PRK01827 526227000285 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 526227000286 dimerization interface [polypeptide binding]; other site 526227000287 active site 526227000288 S-layer homology domain; Region: SLH; pfam00395 526227000289 Spectrin repeat; Region: Spectrin; pfam00435 526227000290 linker region; other site 526227000291 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 526227000292 FOG: CBS domain [General function prediction only]; Region: COG0517 526227000293 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 526227000294 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227000295 Ligand Binding Site [chemical binding]; other site 526227000296 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227000297 Ligand Binding Site [chemical binding]; other site 526227000298 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227000299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227000300 putative substrate translocation pore; other site 526227000301 SurA N-terminal domain; Region: SurA_N_3; cl07813 526227000302 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 526227000303 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 526227000304 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 526227000305 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 526227000306 glutaminase active site [active] 526227000307 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 526227000308 dimer interface [polypeptide binding]; other site 526227000309 active site 526227000310 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 526227000311 dimer interface [polypeptide binding]; other site 526227000312 active site 526227000313 S-layer homology domain; Region: SLH; pfam00395 526227000314 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 526227000315 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 526227000316 putative active site [active] 526227000317 excinuclease ABC subunit B; Provisional; Region: PRK05298 526227000318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227000319 ATP binding site [chemical binding]; other site 526227000320 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227000321 nucleotide binding region [chemical binding]; other site 526227000322 ATP-binding site [chemical binding]; other site 526227000323 Ultra-violet resistance protein B; Region: UvrB; pfam12344 526227000324 UvrB/uvrC motif; Region: UVR; pfam02151 526227000325 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 526227000326 PEGA domain; Region: PEGA; pfam08308 526227000327 PEGA domain; Region: PEGA; pfam08308 526227000328 e3 binding domain; Region: E3_binding; pfam02817 526227000329 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 526227000330 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 526227000331 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 526227000332 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 526227000333 putative NAD(P) binding site [chemical binding]; other site 526227000334 putative substrate binding site [chemical binding]; other site 526227000335 catalytic Zn binding site [ion binding]; other site 526227000336 structural Zn binding site [ion binding]; other site 526227000337 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 526227000338 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 526227000339 RNA binding site [nucleotide binding]; other site 526227000340 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 526227000341 RNA binding site [nucleotide binding]; other site 526227000342 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 526227000343 RNA binding site [nucleotide binding]; other site 526227000344 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 526227000345 RNA binding site [nucleotide binding]; other site 526227000346 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 526227000347 RNA binding site [nucleotide binding]; other site 526227000348 putative transposase OrfB; Reviewed; Region: PHA02517 526227000349 Integrase core domain; Region: rve; pfam00665 526227000350 Integrase core domain; Region: rve_3; pfam13683 526227000351 FOG: CBS domain [General function prediction only]; Region: COG0517 526227000352 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 526227000353 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 526227000354 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 526227000355 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 526227000356 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526227000357 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 526227000358 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526227000359 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 526227000360 NlpC/P60 family; Region: NLPC_P60; pfam00877 526227000361 cytidylate kinase; Provisional; Region: cmk; PRK00023 526227000362 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 526227000363 CMP-binding site; other site 526227000364 The sites determining sugar specificity; other site 526227000365 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227000366 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227000367 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 526227000368 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 526227000369 hinge; other site 526227000370 active site 526227000371 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 526227000372 DHH family; Region: DHH; pfam01368 526227000373 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 526227000374 active site 526227000375 multimer interface [polypeptide binding]; other site 526227000376 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526227000377 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526227000378 active site 526227000379 ATP binding site [chemical binding]; other site 526227000380 substrate binding site [chemical binding]; other site 526227000381 activation loop (A-loop); other site 526227000382 PQQ-like domain; Region: PQQ_2; pfam13360 526227000383 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 526227000384 Trp docking motif [polypeptide binding]; other site 526227000385 active site 526227000386 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 526227000387 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526227000388 metal-binding site [ion binding] 526227000389 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 526227000390 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526227000391 metal-binding site [ion binding] 526227000392 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526227000393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227000394 motif II; other site 526227000395 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 526227000396 putative homodimer interface [polypeptide binding]; other site 526227000397 putative homotetramer interface [polypeptide binding]; other site 526227000398 allosteric switch controlling residues; other site 526227000399 putative metal binding site [ion binding]; other site 526227000400 putative homodimer-homodimer interface [polypeptide binding]; other site 526227000401 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526227000402 metal-binding site [ion binding] 526227000403 Domain of unknown function (DUF305); Region: DUF305; pfam03713 526227000404 Heavy-metal-associated domain; Region: HMA; pfam00403 526227000405 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 526227000406 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526227000407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227000408 motif II; other site 526227000409 Short C-terminal domain; Region: SHOCT; pfam09851 526227000410 Domain of unknown function DUF302; Region: DUF302; pfam03625 526227000411 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 526227000412 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 526227000413 Multicopper oxidase; Region: Cu-oxidase; pfam00394 526227000414 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 526227000415 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 526227000416 Protein of unknown function, DUF; Region: DUF411; cl01142 526227000417 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526227000418 dimerization interface [polypeptide binding]; other site 526227000419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227000420 dimer interface [polypeptide binding]; other site 526227000421 phosphorylation site [posttranslational modification] 526227000422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227000423 ATP binding site [chemical binding]; other site 526227000424 Mg2+ binding site [ion binding]; other site 526227000425 G-X-G motif; other site 526227000426 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227000427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227000428 active site 526227000429 phosphorylation site [posttranslational modification] 526227000430 intermolecular recognition site; other site 526227000431 dimerization interface [polypeptide binding]; other site 526227000432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227000433 DNA binding site [nucleotide binding] 526227000434 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 526227000435 CCC1; Region: CCC1; cd02435 526227000436 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 526227000437 EamA-like transporter family; Region: EamA; pfam00892 526227000438 EamA-like transporter family; Region: EamA; pfam00892 526227000439 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 526227000440 catalytic residues [active] 526227000441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227000442 binding surface 526227000443 TPR motif; other site 526227000444 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000445 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000446 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000447 Tetratricopeptide repeat; Region: TPR_10; cl17452 526227000448 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227000449 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227000450 metal binding site [ion binding]; metal-binding site 526227000451 active site 526227000452 I-site; other site 526227000453 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 526227000454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227000455 Walker A motif; other site 526227000456 ATP binding site [chemical binding]; other site 526227000457 Walker B motif; other site 526227000458 arginine finger; other site 526227000459 phosphopentomutase; Provisional; Region: PRK05362 526227000460 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 526227000461 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 526227000462 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526227000463 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526227000464 NAD(P) binding site [chemical binding]; other site 526227000465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227000466 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 526227000467 NAD(P) binding site [chemical binding]; other site 526227000468 active site 526227000469 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526227000470 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 526227000471 putative NAD(P) binding site [chemical binding]; other site 526227000472 catalytic Zn binding site [ion binding]; other site 526227000473 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227000474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227000475 conserved gate region; other site 526227000476 ABC-ATPase subunit interface; other site 526227000477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227000478 dimer interface [polypeptide binding]; other site 526227000479 conserved gate region; other site 526227000480 putative PBP binding loops; other site 526227000481 ABC-ATPase subunit interface; other site 526227000482 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227000483 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227000484 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227000485 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227000486 DNA binding site [nucleotide binding] 526227000487 domain linker motif; other site 526227000488 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227000489 dimerization interface [polypeptide binding]; other site 526227000490 ligand binding site [chemical binding]; other site 526227000491 Uncharacterized conserved protein [Function unknown]; Region: COG1624 526227000492 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 526227000493 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 526227000494 active site 526227000495 catalytic residues [active] 526227000496 metal binding site [ion binding]; metal-binding site 526227000497 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 526227000498 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 526227000499 putative active site [active] 526227000500 substrate binding site [chemical binding]; other site 526227000501 putative cosubstrate binding site; other site 526227000502 catalytic site [active] 526227000503 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 526227000504 substrate binding site [chemical binding]; other site 526227000505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 526227000506 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 526227000507 CPxP motif; other site 526227000508 Peroxiredoxin family protein [General function prediction only]; Region: COG2210 526227000509 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 526227000510 6-phosphofructokinase; Provisional; Region: PRK03202 526227000511 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 526227000512 active site 526227000513 ADP/pyrophosphate binding site [chemical binding]; other site 526227000514 dimerization interface [polypeptide binding]; other site 526227000515 allosteric effector site; other site 526227000516 fructose-1,6-bisphosphate binding site; other site 526227000517 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 526227000518 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526227000519 DNA binding residues [nucleotide binding] 526227000520 dimer interface [polypeptide binding]; other site 526227000521 putative transposase OrfB; Reviewed; Region: PHA02517 526227000522 Integrase core domain; Region: rve; pfam00665 526227000523 Integrase core domain; Region: rve_3; pfam13683 526227000524 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 526227000525 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 526227000526 GDP-binding site [chemical binding]; other site 526227000527 ACT binding site; other site 526227000528 IMP binding site; other site 526227000529 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 526227000530 putative active site [active] 526227000531 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 526227000532 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 526227000533 G1 box; other site 526227000534 putative GEF interaction site [polypeptide binding]; other site 526227000535 GTP/Mg2+ binding site [chemical binding]; other site 526227000536 Switch I region; other site 526227000537 G2 box; other site 526227000538 G3 box; other site 526227000539 Switch II region; other site 526227000540 G4 box; other site 526227000541 G5 box; other site 526227000542 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 526227000543 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 526227000544 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 526227000545 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 526227000546 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 526227000547 DinB family; Region: DinB; cl17821 526227000548 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 526227000549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227000550 motif II; other site 526227000551 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 526227000552 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 526227000553 substrate binding pocket [chemical binding]; other site 526227000554 membrane-bound complex binding site; other site 526227000555 hinge residues; other site 526227000556 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 526227000557 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 526227000558 Walker A/P-loop; other site 526227000559 ATP binding site [chemical binding]; other site 526227000560 Q-loop/lid; other site 526227000561 ABC transporter signature motif; other site 526227000562 Walker B; other site 526227000563 D-loop; other site 526227000564 H-loop/switch region; other site 526227000565 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 526227000566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227000567 dimer interface [polypeptide binding]; other site 526227000568 conserved gate region; other site 526227000569 ABC-ATPase subunit interface; other site 526227000570 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227000571 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 526227000572 Walker A/P-loop; other site 526227000573 ATP binding site [chemical binding]; other site 526227000574 Q-loop/lid; other site 526227000575 ABC transporter signature motif; other site 526227000576 Walker B; other site 526227000577 D-loop; other site 526227000578 H-loop/switch region; other site 526227000579 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227000580 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526227000581 TM-ABC transporter signature motif; other site 526227000582 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227000583 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227000584 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227000585 DNA binding site [nucleotide binding] 526227000586 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227000587 ligand binding site [chemical binding]; other site 526227000588 dimerization interface [polypeptide binding]; other site 526227000589 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526227000590 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 526227000591 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526227000592 Predicted dehydrogenase [General function prediction only]; Region: COG0579 526227000593 hydroxyglutarate oxidase; Provisional; Region: PRK11728 526227000594 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526227000595 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227000596 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 526227000597 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526227000598 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227000599 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 526227000600 DNA Polymerase alpha zinc finger; Region: zf-DNA_Pol; pfam08996 526227000601 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 526227000602 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 526227000603 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 526227000604 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 526227000605 PEGA domain; Region: PEGA; pfam08308 526227000606 PEGA domain; Region: PEGA; pfam08308 526227000607 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227000608 active site 526227000609 Ferredoxin [Energy production and conversion]; Region: COG1146 526227000610 4Fe-4S binding domain; Region: Fer4; cl02805 526227000611 PGAP1-like protein; Region: PGAP1; pfam07819 526227000612 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227000613 TAP-like protein; Region: Abhydrolase_4; pfam08386 526227000614 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227000615 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 526227000616 catalytic site [active] 526227000617 TAP-like protein; Region: Abhydrolase_4; pfam08386 526227000618 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227000619 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 526227000620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 526227000621 Putative esterase; Region: Esterase; pfam00756 526227000622 Cupin domain; Region: Cupin_2; pfam07883 526227000623 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 526227000624 active site 526227000625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227000626 binding surface 526227000627 TPR motif; other site 526227000628 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000630 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 526227000631 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 526227000632 active site 526227000633 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526227000634 Predicted ATPase [General function prediction only]; Region: COG3899 526227000635 AAA ATPase domain; Region: AAA_16; pfam13191 526227000636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 526227000637 binding surface 526227000638 TPR motif; other site 526227000639 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526227000640 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 526227000641 Walker A/P-loop; other site 526227000642 ATP binding site [chemical binding]; other site 526227000643 Q-loop/lid; other site 526227000644 ABC transporter signature motif; other site 526227000645 Walker B; other site 526227000646 D-loop; other site 526227000647 H-loop/switch region; other site 526227000648 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227000649 Flagellin N-methylase; Region: FliB; cl00497 526227000650 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526227000651 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 526227000652 substrate binding site [chemical binding]; other site 526227000653 dimer interface [polypeptide binding]; other site 526227000654 ATP binding site [chemical binding]; other site 526227000655 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526227000656 phosphate binding site [ion binding]; other site 526227000657 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 526227000658 putative active site [active] 526227000659 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 526227000660 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 526227000661 motif 1; other site 526227000662 active site 526227000663 motif 2; other site 526227000664 motif 3; other site 526227000665 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 526227000666 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 526227000667 YceG-like family; Region: YceG; pfam02618 526227000668 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 526227000669 dimerization interface [polypeptide binding]; other site 526227000670 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 526227000671 PhoD-like phosphatase; Region: PhoD; pfam09423 526227000672 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 526227000673 putative active site [active] 526227000674 putative metal binding site [ion binding]; other site 526227000675 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 526227000676 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227000677 Ligand Binding Site [chemical binding]; other site 526227000678 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 526227000679 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 526227000680 Walker A motif; other site 526227000681 ATP binding site [chemical binding]; other site 526227000682 Walker B motif; other site 526227000683 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 526227000684 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 526227000685 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 526227000686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227000687 TPR motif; other site 526227000688 binding surface 526227000689 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000690 O-Antigen ligase; Region: Wzy_C; pfam04932 526227000691 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227000692 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 526227000693 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 526227000694 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 526227000695 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 526227000696 dimer interface [polypeptide binding]; other site 526227000697 active site 526227000698 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 526227000699 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 526227000700 Substrate binding site; other site 526227000701 Mg++ binding site; other site 526227000702 metal-binding site 526227000703 Mg++ binding site; other site 526227000704 metal-binding site 526227000705 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 526227000706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227000707 active site 526227000708 motif I; other site 526227000709 motif II; other site 526227000710 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227000711 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 526227000712 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 526227000713 oligomer interface [polypeptide binding]; other site 526227000714 Bacterial transcriptional activator domain; Region: BTAD; smart01043 526227000715 Predicted ATPase [General function prediction only]; Region: COG3899 526227000716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227000717 TPR motif; other site 526227000718 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000719 binding surface 526227000720 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 526227000721 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 526227000722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227000723 putative substrate translocation pore; other site 526227000724 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 526227000725 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 526227000726 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 526227000727 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 526227000728 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 526227000729 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 526227000730 [4Fe-4S] binding site [ion binding]; other site 526227000731 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526227000732 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526227000733 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526227000734 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 526227000735 molybdopterin cofactor binding site; other site 526227000736 Cytochrome c; Region: Cytochrom_C; pfam00034 526227000737 GAF domain; Region: GAF; cl17456 526227000738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 526227000739 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 526227000740 DNA binding site [nucleotide binding] 526227000741 cyclase homology domain; Region: CHD; cd07302 526227000742 nucleotidyl binding site; other site 526227000743 metal binding site [ion binding]; metal-binding site 526227000744 dimer interface [polypeptide binding]; other site 526227000745 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 526227000746 cyclase homology domain; Region: CHD; cd07302 526227000747 dimer interface [polypeptide binding]; other site 526227000748 nucleotidyl binding site; other site 526227000749 metal binding site [ion binding]; metal-binding site 526227000750 Predicted ATPase [General function prediction only]; Region: COG3899 526227000751 AAA ATPase domain; Region: AAA_16; pfam13191 526227000752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227000753 TPR motif; other site 526227000754 binding surface 526227000755 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000756 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227000757 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 526227000758 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227000759 ligand binding site [chemical binding]; other site 526227000760 flexible hinge region; other site 526227000761 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 526227000762 putative switch regulator; other site 526227000763 non-specific DNA interactions [nucleotide binding]; other site 526227000764 DNA binding site [nucleotide binding] 526227000765 sequence specific DNA binding site [nucleotide binding]; other site 526227000766 putative cAMP binding site [chemical binding]; other site 526227000767 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 526227000768 YwiC-like protein; Region: YwiC; pfam14256 526227000769 Ferredoxin [Energy production and conversion]; Region: COG1146 526227000770 4Fe-4S binding domain; Region: Fer4; cl02805 526227000771 Ferredoxin [Energy production and conversion]; Region: COG1146 526227000772 4Fe-4S binding domain; Region: Fer4; pfam00037 526227000773 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 526227000774 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 526227000775 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 526227000776 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 526227000777 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 526227000778 minor groove reading motif; other site 526227000779 helix-hairpin-helix signature motif; other site 526227000780 substrate binding pocket [chemical binding]; other site 526227000781 active site 526227000782 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 526227000783 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 526227000784 DNA binding and oxoG recognition site [nucleotide binding] 526227000785 Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028 526227000786 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 526227000787 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227000788 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227000789 active site 526227000790 metal binding site [ion binding]; metal-binding site 526227000791 NAD synthetase; Provisional; Region: PRK13980 526227000792 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 526227000793 homodimer interface [polypeptide binding]; other site 526227000794 NAD binding pocket [chemical binding]; other site 526227000795 ATP binding pocket [chemical binding]; other site 526227000796 Mg binding site [ion binding]; other site 526227000797 active-site loop [active] 526227000798 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 526227000799 active site 526227000800 catalytic triad [active] 526227000801 dimer interface [polypeptide binding]; other site 526227000802 Uncharacterized conserved protein [Function unknown]; Region: COG3339 526227000803 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526227000804 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526227000805 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 526227000806 NADP binding site [chemical binding]; other site 526227000807 dimer interface [polypeptide binding]; other site 526227000808 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 526227000809 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 526227000810 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 526227000811 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 526227000812 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 526227000813 putative active site [active] 526227000814 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227000815 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227000816 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 526227000817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227000818 dimer interface [polypeptide binding]; other site 526227000819 conserved gate region; other site 526227000820 putative PBP binding loops; other site 526227000821 ABC-ATPase subunit interface; other site 526227000822 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227000823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227000824 dimer interface [polypeptide binding]; other site 526227000825 conserved gate region; other site 526227000826 putative PBP binding loops; other site 526227000827 ABC-ATPase subunit interface; other site 526227000828 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 526227000829 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 526227000830 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 526227000831 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227000832 active site 526227000833 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 526227000834 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 526227000835 dimer interface [polypeptide binding]; other site 526227000836 active site 526227000837 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 526227000838 dimer interface [polypeptide binding]; other site 526227000839 active site 526227000840 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 526227000841 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 526227000842 putative active site cavity [active] 526227000843 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 526227000844 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 526227000845 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 526227000846 active site 526227000847 FMN binding site [chemical binding]; other site 526227000848 substrate binding site [chemical binding]; other site 526227000849 homotetramer interface [polypeptide binding]; other site 526227000850 catalytic residue [active] 526227000851 phosphoglucomutase; Validated; Region: PRK07564 526227000852 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 526227000853 active site 526227000854 substrate binding site [chemical binding]; other site 526227000855 metal binding site [ion binding]; metal-binding site 526227000856 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 526227000857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227000858 dimerization interface [polypeptide binding]; other site 526227000859 putative DNA binding site [nucleotide binding]; other site 526227000860 putative Zn2+ binding site [ion binding]; other site 526227000861 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 526227000862 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526227000863 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227000864 active site 526227000865 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 526227000866 Ligand binding site [chemical binding]; other site 526227000867 Electron transfer flavoprotein domain; Region: ETF; pfam01012 526227000868 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 526227000869 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 526227000870 Ligand Binding Site [chemical binding]; other site 526227000871 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 526227000872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227000873 putative substrate translocation pore; other site 526227000874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227000875 putative DNA binding site [nucleotide binding]; other site 526227000876 putative Zn2+ binding site [ion binding]; other site 526227000877 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 526227000878 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 526227000879 Predicted transcriptional regulator [Transcription]; Region: COG2345 526227000880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227000881 putative DNA binding site [nucleotide binding]; other site 526227000882 putative Zn2+ binding site [ion binding]; other site 526227000883 DinB superfamily; Region: DinB_2; pfam12867 526227000884 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 526227000885 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 526227000886 NAD binding site [chemical binding]; other site 526227000887 homotetramer interface [polypeptide binding]; other site 526227000888 homodimer interface [polypeptide binding]; other site 526227000889 substrate binding site [chemical binding]; other site 526227000890 active site 526227000891 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 526227000892 dihydropteroate synthase; Region: DHPS; TIGR01496 526227000893 substrate binding pocket [chemical binding]; other site 526227000894 dimer interface [polypeptide binding]; other site 526227000895 inhibitor binding site; inhibition site 526227000896 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 526227000897 active site 526227000898 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 526227000899 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 526227000900 calcium binding site 2 [ion binding]; other site 526227000901 active site 526227000902 catalytic triad [active] 526227000903 calcium binding site 1 [ion binding]; other site 526227000904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 526227000905 MOSC domain; Region: MOSC; pfam03473 526227000906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227000907 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227000908 Protein of unknown function DUF72; Region: DUF72; pfam01904 526227000909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227000910 S-adenosylmethionine binding site [chemical binding]; other site 526227000911 diaminopimelate decarboxylase; Region: lysA; TIGR01048 526227000912 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 526227000913 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 526227000914 catalytic residue [active] 526227000915 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 526227000916 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 526227000917 catalytic triad [active] 526227000918 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 526227000919 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526227000920 putative transposase OrfB; Reviewed; Region: PHA02517 526227000921 Integrase core domain; Region: rve; pfam00665 526227000922 Integrase core domain; Region: rve_3; pfam13683 526227000923 Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210 526227000924 dimer interface [polypeptide binding]; other site 526227000925 active site 526227000926 catalytic residue [active] 526227000927 metal binding site [ion binding]; metal-binding site 526227000928 Cupin domain; Region: Cupin_2; pfam07883 526227000929 DNA polymerase IV; Reviewed; Region: PRK03103 526227000930 Y-family of DNA polymerases; Region: PolY; cd00424 526227000931 active site 526227000932 DNA binding site [nucleotide binding] 526227000933 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 526227000934 alanine racemase; Reviewed; Region: alr; PRK00053 526227000935 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 526227000936 active site 526227000937 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 526227000938 dimer interface [polypeptide binding]; other site 526227000939 substrate binding site [chemical binding]; other site 526227000940 catalytic residues [active] 526227000941 Protein of unknown function (DUF3208); Region: DUF3208; pfam11482 526227000942 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 526227000943 putative ligand binding site [chemical binding]; other site 526227000944 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 526227000945 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 526227000946 phosphate binding site [ion binding]; other site 526227000947 putative substrate binding pocket [chemical binding]; other site 526227000948 dimer interface [polypeptide binding]; other site 526227000949 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 526227000950 AAA domain; Region: AAA_18; pfam13238 526227000951 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 526227000952 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 526227000953 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14468 526227000954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227000955 FeS/SAM binding site; other site 526227000956 GAF domain; Region: GAF; pfam01590 526227000957 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227000958 metal binding site [ion binding]; metal-binding site 526227000959 active site 526227000960 I-site; other site 526227000961 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526227000962 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 526227000963 MoaE interaction surface [polypeptide binding]; other site 526227000964 MoeB interaction surface [polypeptide binding]; other site 526227000965 thiocarboxylated glycine; other site 526227000966 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 526227000967 MoaE homodimer interface [polypeptide binding]; other site 526227000968 MoaD interaction [polypeptide binding]; other site 526227000969 active site residues [active] 526227000970 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 526227000971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227000972 ATP binding site [chemical binding]; other site 526227000973 Mg2+ binding site [ion binding]; other site 526227000974 G-X-G motif; other site 526227000975 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 526227000976 anchoring element; other site 526227000977 dimer interface [polypeptide binding]; other site 526227000978 ATP binding site [chemical binding]; other site 526227000979 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 526227000980 active site 526227000981 putative metal-binding site [ion binding]; other site 526227000982 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 526227000983 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 526227000984 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 526227000985 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 526227000986 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526227000987 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 526227000988 Probable Catalytic site; other site 526227000989 metal-binding site 526227000990 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526227000991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526227000992 active site 526227000993 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526227000994 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227000995 active site 526227000996 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 526227000997 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 526227000998 glutamine binding [chemical binding]; other site 526227000999 catalytic triad [active] 526227001000 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 526227001001 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 526227001002 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 526227001003 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 526227001004 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227001005 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227001006 catalytic residue [active] 526227001007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 526227001008 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 526227001009 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 526227001010 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227001011 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227001012 metal binding site [ion binding]; metal-binding site 526227001013 active site 526227001014 I-site; other site 526227001015 acetyl-lysine deacetylase; Provisional; Region: PRK04443 526227001016 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 526227001017 metal binding site [ion binding]; metal-binding site 526227001018 putative dimer interface [polypeptide binding]; other site 526227001019 acetylornithine aminotransferase; Provisional; Region: PRK02627 526227001020 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227001021 inhibitor-cofactor binding pocket; inhibition site 526227001022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227001023 catalytic residue [active] 526227001024 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 526227001025 catalytic center binding site [active] 526227001026 ATP binding site [chemical binding]; other site 526227001027 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227001028 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526227001029 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 526227001030 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 526227001031 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526227001032 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526227001033 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 526227001034 metal binding site 2 [ion binding]; metal-binding site 526227001035 putative DNA binding helix; other site 526227001036 metal binding site 1 [ion binding]; metal-binding site 526227001037 dimer interface [polypeptide binding]; other site 526227001038 structural Zn2+ binding site [ion binding]; other site 526227001039 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 526227001040 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 526227001041 domain interfaces; other site 526227001042 active site 526227001043 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 526227001044 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 526227001045 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 526227001046 substrate binding site [chemical binding]; other site 526227001047 hypothetical protein; Reviewed; Region: PRK12497 526227001048 pantothenate kinase; Reviewed; Region: PRK13318 526227001049 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 526227001050 Flavoprotein; Region: Flavoprotein; pfam02441 526227001051 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 526227001052 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227001053 dimerization interface [polypeptide binding]; other site 526227001054 putative DNA binding site [nucleotide binding]; other site 526227001055 putative Zn2+ binding site [ion binding]; other site 526227001056 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 526227001057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227001058 Walker A/P-loop; other site 526227001059 ATP binding site [chemical binding]; other site 526227001060 Q-loop/lid; other site 526227001061 ABC transporter signature motif; other site 526227001062 Walker B; other site 526227001063 D-loop; other site 526227001064 H-loop/switch region; other site 526227001065 S-layer homology domain; Region: SLH; pfam00395 526227001066 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 526227001067 dimer interface [polypeptide binding]; other site 526227001068 substrate binding site [chemical binding]; other site 526227001069 ATP binding site [chemical binding]; other site 526227001070 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 526227001071 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 526227001072 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 526227001073 ThiS interaction site; other site 526227001074 putative active site [active] 526227001075 tetramer interface [polypeptide binding]; other site 526227001076 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 526227001077 thiS-thiF/thiG interaction site; other site 526227001078 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 526227001079 thiamine phosphate binding site [chemical binding]; other site 526227001080 active site 526227001081 pyrophosphate binding site [ion binding]; other site 526227001082 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526227001083 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526227001084 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526227001085 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 526227001086 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 526227001087 catalytic triad [active] 526227001088 putative active site [active] 526227001089 putative transposase OrfB; Reviewed; Region: PHA02517 526227001090 Integrase core domain; Region: rve; pfam00665 526227001091 Integrase core domain; Region: rve_3; pfam13683 526227001092 Integral membrane protein DUF92; Region: DUF92; cl00793 526227001093 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 526227001094 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227001095 Zn2+ binding site [ion binding]; other site 526227001096 Mg2+ binding site [ion binding]; other site 526227001097 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 526227001098 synthetase active site [active] 526227001099 NTP binding site [chemical binding]; other site 526227001100 metal binding site [ion binding]; metal-binding site 526227001101 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 526227001102 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 526227001103 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 526227001104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526227001105 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 526227001106 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526227001107 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 526227001108 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 526227001109 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 526227001110 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 526227001111 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 526227001112 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 526227001113 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 526227001114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001115 Walker A motif; other site 526227001116 ATP binding site [chemical binding]; other site 526227001117 Walker B motif; other site 526227001118 arginine finger; other site 526227001119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001120 Walker A motif; other site 526227001121 ATP binding site [chemical binding]; other site 526227001122 Walker B motif; other site 526227001123 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 526227001124 Uncharacterized conserved protein [Function unknown]; Region: COG2127 526227001125 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 526227001126 putative homodimer interface [polypeptide binding]; other site 526227001127 putative homotetramer interface [polypeptide binding]; other site 526227001128 putative allosteric switch controlling residues; other site 526227001129 putative metal binding site [ion binding]; other site 526227001130 putative homodimer-homodimer interface [polypeptide binding]; other site 526227001131 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14963 526227001132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001133 Walker A motif; other site 526227001134 ATP binding site [chemical binding]; other site 526227001135 Walker B motif; other site 526227001136 arginine finger; other site 526227001137 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 526227001138 putative metal binding site [ion binding]; other site 526227001139 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 526227001140 dimer interface [polypeptide binding]; other site 526227001141 FMN binding site [chemical binding]; other site 526227001142 NADPH bind site [chemical binding]; other site 526227001143 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 526227001144 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 526227001145 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 526227001146 peptide chain release factor 2; Validated; Region: prfB; PRK00578 526227001147 PCRF domain; Region: PCRF; pfam03462 526227001148 RF-1 domain; Region: RF-1; pfam00472 526227001149 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 526227001150 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 526227001151 hinge; other site 526227001152 active site 526227001153 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227001154 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227001155 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 526227001156 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 526227001157 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526227001158 catalytic residue [active] 526227001159 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 526227001160 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 526227001161 peptide chain release factor 1; Provisional; Region: PRK04011 526227001162 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 526227001163 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 526227001164 putative dimer interface [polypeptide binding]; other site 526227001165 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 526227001166 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 526227001167 active site 526227001168 Rhomboid family; Region: Rhomboid; pfam01694 526227001169 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 526227001170 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 526227001171 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 526227001172 TrkA-C domain; Region: TrkA_C; pfam02080 526227001173 Predicted membrane protein [Function unknown]; Region: COG3431 526227001174 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 526227001175 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 526227001176 putative dimer interface [polypeptide binding]; other site 526227001177 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 526227001178 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 526227001179 catalytic residues [active] 526227001180 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 526227001181 dinuclear metal binding motif [ion binding]; other site 526227001182 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 526227001183 catalytic residues [active] 526227001184 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 526227001185 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 526227001186 dimer interface [polypeptide binding]; other site 526227001187 catalytic triad [active] 526227001188 Ferritin-like domain; Region: Ferritin; pfam00210 526227001189 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 526227001190 dinuclear metal binding motif [ion binding]; other site 526227001191 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 526227001192 Clp amino terminal domain; Region: Clp_N; pfam02861 526227001193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001194 Walker A motif; other site 526227001195 ATP binding site [chemical binding]; other site 526227001196 Walker B motif; other site 526227001197 arginine finger; other site 526227001198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001199 Walker A motif; other site 526227001200 ATP binding site [chemical binding]; other site 526227001201 Walker B motif; other site 526227001202 arginine finger; other site 526227001203 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 526227001204 amidase; Provisional; Region: PRK06828 526227001205 Amidase; Region: Amidase; pfam01425 526227001206 DNA primase domain-containing protein; Region: PHA02415 526227001207 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 526227001208 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 526227001209 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526227001210 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526227001211 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526227001212 active site 526227001213 catalytic tetrad [active] 526227001214 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 526227001215 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526227001216 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 526227001217 chaperone protein DnaJ; Provisional; Region: PRK14299 526227001218 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 526227001219 HSP70 interaction site [polypeptide binding]; other site 526227001220 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 526227001221 substrate binding site [polypeptide binding]; other site 526227001222 dimer interface [polypeptide binding]; other site 526227001223 GrpE; Region: GrpE; pfam01025 526227001224 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 526227001225 dimer interface [polypeptide binding]; other site 526227001226 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 526227001227 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 526227001228 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 526227001229 nucleotide binding site [chemical binding]; other site 526227001230 NEF interaction site [polypeptide binding]; other site 526227001231 SBD interface [polypeptide binding]; other site 526227001232 FtsH Extracellular; Region: FtsH_ext; pfam06480 526227001233 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 526227001234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001235 Walker A motif; other site 526227001236 ATP binding site [chemical binding]; other site 526227001237 Walker B motif; other site 526227001238 arginine finger; other site 526227001239 Peptidase family M41; Region: Peptidase_M41; pfam01434 526227001240 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 526227001241 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 526227001242 dimerization interface [polypeptide binding]; other site 526227001243 DPS ferroxidase diiron center [ion binding]; other site 526227001244 ion pore; other site 526227001245 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 526227001246 IHF dimer interface [polypeptide binding]; other site 526227001247 IHF - DNA interface [nucleotide binding]; other site 526227001248 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 526227001249 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 526227001250 putative acyl-acceptor binding pocket; other site 526227001251 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 526227001252 Uncharacterized conserved protein [Function unknown]; Region: COG1543 526227001253 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 526227001254 AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251 526227001255 putative nucleotide binding site [chemical binding]; other site 526227001256 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 526227001257 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 526227001258 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 526227001259 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 526227001260 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526227001261 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 526227001262 NAD-dependent deacetylase; Provisional; Region: PRK00481 526227001263 homoaconitate hydratase small subunit; Provisional; Region: PRK14023 526227001264 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 526227001265 substrate binding site [chemical binding]; other site 526227001266 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 526227001267 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 526227001268 substrate binding site [chemical binding]; other site 526227001269 ligand binding site [chemical binding]; other site 526227001270 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 526227001271 YcfA-like protein; Region: YcfA; cl00752 526227001272 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 526227001273 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 526227001274 active site 526227001275 catalytic residues [active] 526227001276 metal binding site [ion binding]; metal-binding site 526227001277 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14835 526227001278 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 526227001279 catalytic residue [active] 526227001280 putative FPP diphosphate binding site; other site 526227001281 putative FPP binding hydrophobic cleft; other site 526227001282 dimer interface [polypeptide binding]; other site 526227001283 putative IPP diphosphate binding site; other site 526227001284 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 526227001285 RNA/DNA hybrid binding site [nucleotide binding]; other site 526227001286 active site 526227001287 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 526227001288 Immunoglobulin domain; Region: Ig; cl11960 526227001289 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 526227001290 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 526227001291 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 526227001292 DctM-like transporters; Region: DctM; pfam06808 526227001293 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 526227001294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227001295 putative substrate translocation pore; other site 526227001296 MFS/sugar transport protein; Region: MFS_2; pfam13347 526227001297 putative transposase OrfB; Reviewed; Region: PHA02517 526227001298 Integrase core domain; Region: rve; pfam00665 526227001299 Integrase core domain; Region: rve_3; pfam13683 526227001300 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 526227001301 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 526227001302 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227001303 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227001304 DNA binding site [nucleotide binding] 526227001305 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227001306 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526227001307 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 526227001308 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227001309 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526227001310 DinB superfamily; Region: DinB_2; pfam12867 526227001311 metal-dependent hydrolase; Provisional; Region: PRK13291 526227001312 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 526227001313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227001314 NAD(P) binding site [chemical binding]; other site 526227001315 active site 526227001316 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 526227001317 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 526227001318 NADP binding site [chemical binding]; other site 526227001319 dimer interface [polypeptide binding]; other site 526227001320 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227001321 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 526227001322 dimer interface [polypeptide binding]; other site 526227001323 ligand binding site [chemical binding]; other site 526227001324 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 526227001325 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 526227001326 intrachain domain interface; other site 526227001327 interchain domain interface [polypeptide binding]; other site 526227001328 heme bL binding site [chemical binding]; other site 526227001329 heme bH binding site [chemical binding]; other site 526227001330 Qo binding site; other site 526227001331 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 526227001332 intrachain domain interface; other site 526227001333 Qo binding site; other site 526227001334 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 526227001335 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 526227001336 iron-sulfur cluster [ion binding]; other site 526227001337 [2Fe-2S] cluster binding site [ion binding]; other site 526227001338 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 526227001339 Cytochrome c; Region: Cytochrom_C; pfam00034 526227001340 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 526227001341 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 526227001342 Metal-binding active site; metal-binding site 526227001343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227001344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526227001345 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227001346 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526227001347 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227001348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001349 putative PBP binding loops; other site 526227001350 ABC-ATPase subunit interface; other site 526227001351 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 526227001352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001353 dimer interface [polypeptide binding]; other site 526227001354 putative PBP binding loops; other site 526227001355 ABC-ATPase subunit interface; other site 526227001356 hypothetical protein; Provisional; Region: PRK01184 526227001357 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 526227001358 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 526227001359 metal binding site [ion binding]; metal-binding site 526227001360 substrate binding pocket [chemical binding]; other site 526227001361 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 526227001362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227001363 active site 526227001364 motif I; other site 526227001365 motif II; other site 526227001366 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 526227001367 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 526227001368 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227001369 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227001370 catalytic residue [active] 526227001371 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 526227001372 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 526227001373 catalytic residues [active] 526227001374 catalytic nucleophile [active] 526227001375 Recombinase; Region: Recombinase; pfam07508 526227001376 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 526227001377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227001378 non-specific DNA binding site [nucleotide binding]; other site 526227001379 salt bridge; other site 526227001380 sequence-specific DNA binding site [nucleotide binding]; other site 526227001381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227001382 non-specific DNA binding site [nucleotide binding]; other site 526227001383 salt bridge; other site 526227001384 sequence-specific DNA binding site [nucleotide binding]; other site 526227001385 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 526227001386 D5 N terminal like; Region: D5_N; pfam08706 526227001387 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 526227001388 Protein of unknown function (DUF805); Region: DUF805; cl01224 526227001389 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 526227001390 AAA-like domain; Region: AAA_10; pfam12846 526227001391 Domain of unknown function DUF87; Region: DUF87; pfam01935 526227001392 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 526227001393 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 526227001394 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 526227001395 catalytic site [active] 526227001396 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 526227001397 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 526227001398 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526227001399 catalytic residue [active] 526227001400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001401 Walker A motif; other site 526227001402 ATP binding site [chemical binding]; other site 526227001403 Walker B motif; other site 526227001404 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 526227001405 DNA binding residues [nucleotide binding] 526227001406 S-layer homology domain; Region: SLH; pfam00395 526227001407 Prefoldin subunit; Region: Prefoldin_2; pfam01920 526227001408 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 526227001409 Homeodomain-like domain; Region: HTH_23; pfam13384 526227001410 Winged helix-turn helix; Region: HTH_29; pfam13551 526227001411 Homeodomain-like domain; Region: HTH_32; pfam13565 526227001412 Integrase core domain; Region: rve; pfam00665 526227001413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 526227001414 Integrase core domain; Region: rve_3; pfam13683 526227001415 RES domain; Region: RES; cl02411 526227001416 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 526227001417 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 526227001418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526227001419 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 526227001420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227001421 Walker A/P-loop; other site 526227001422 ATP binding site [chemical binding]; other site 526227001423 Q-loop/lid; other site 526227001424 ABC transporter signature motif; other site 526227001425 Walker B; other site 526227001426 D-loop; other site 526227001427 H-loop/switch region; other site 526227001428 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 526227001429 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 526227001430 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 526227001431 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 526227001432 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 526227001433 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526227001434 active site 526227001435 catalytic tetrad [active] 526227001436 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 526227001437 active site 526227001438 NTP binding site [chemical binding]; other site 526227001439 metal binding triad [ion binding]; metal-binding site 526227001440 KNTase C-terminal domain; Region: KNTase_C; pfam07827 526227001441 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526227001442 Cytochrome P450; Region: p450; cl12078 526227001443 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 526227001444 putative active site [active] 526227001445 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 526227001446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 526227001447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227001448 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 526227001449 Probable transposase; Region: OrfB_IS605; pfam01385 526227001450 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227001451 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 526227001452 Restriction endonuclease [Defense mechanisms]; Region: COG3587 526227001453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227001454 ATP binding site [chemical binding]; other site 526227001455 putative Mg++ binding site [ion binding]; other site 526227001456 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 526227001457 DNA methylase; Region: N6_N4_Mtase; cl17433 526227001458 DNA methylase; Region: N6_N4_Mtase; pfam01555 526227001459 DNA methylase; Region: N6_N4_Mtase; pfam01555 526227001460 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227001461 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 526227001462 active site 526227001463 catalytic residues [active] 526227001464 DNA binding site [nucleotide binding] 526227001465 Int/Topo IB signature motif; other site 526227001466 AAA domain; Region: AAA_30; pfam13604 526227001467 AAA domain; Region: AAA_11; pfam13086 526227001468 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 526227001469 AAA domain; Region: AAA_12; pfam13087 526227001470 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 526227001471 DNA methylase; Region: N6_N4_Mtase; pfam01555 526227001472 DNA methylase; Region: N6_N4_Mtase; cl17433 526227001473 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 526227001474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227001475 putative DNA binding site [nucleotide binding]; other site 526227001476 putative Zn2+ binding site [ion binding]; other site 526227001477 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 526227001478 Part of AAA domain; Region: AAA_19; pfam13245 526227001479 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 526227001480 Family description; Region: UvrD_C_2; pfam13538 526227001481 Staphylococcal nuclease homologues; Region: SNc; smart00318 526227001482 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 526227001483 Catalytic site; other site 526227001484 Excalibur calcium-binding domain; Region: Excalibur; smart00894 526227001485 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 526227001486 putative FMN binding site [chemical binding]; other site 526227001487 NADPH bind site [chemical binding]; other site 526227001488 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227001489 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526227001490 Walker A/P-loop; other site 526227001491 ATP binding site [chemical binding]; other site 526227001492 Q-loop/lid; other site 526227001493 ABC transporter signature motif; other site 526227001494 Walker B; other site 526227001495 D-loop; other site 526227001496 H-loop/switch region; other site 526227001497 ABC-2 type transporter; Region: ABC2_membrane; cl17235 526227001498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 526227001499 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 526227001500 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 526227001501 transmembrane helices; other site 526227001502 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 526227001503 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 526227001504 putative active site [active] 526227001505 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 526227001506 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 526227001507 Walker A motif; other site 526227001508 ATP binding site [chemical binding]; other site 526227001509 Walker B motif; other site 526227001510 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 526227001511 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 526227001512 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 526227001513 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 526227001514 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 526227001515 Walker A motif; other site 526227001516 ATP binding site [chemical binding]; other site 526227001517 Walker B motif; other site 526227001518 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 526227001519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227001520 active site 526227001521 motif I; other site 526227001522 motif II; other site 526227001523 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 526227001524 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 526227001525 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 526227001526 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 526227001527 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 526227001528 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 526227001529 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 526227001530 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 526227001531 active site 526227001532 Zn binding site [ion binding]; other site 526227001533 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 526227001534 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 526227001535 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 526227001536 Predicted esterase [General function prediction only]; Region: COG0400 526227001537 putative hydrolase; Provisional; Region: PRK11460 526227001538 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 526227001539 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227001540 Zn binding site [ion binding]; other site 526227001541 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 526227001542 Zn binding site [ion binding]; other site 526227001543 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227001544 YceI-like domain; Region: YceI; smart00867 526227001545 Predicted transcriptional regulators [Transcription]; Region: COG1733 526227001546 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 526227001547 Predicted transcriptional regulators [Transcription]; Region: COG1733 526227001548 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 526227001549 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 526227001550 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 526227001551 ring oligomerisation interface [polypeptide binding]; other site 526227001552 ATP/Mg binding site [chemical binding]; other site 526227001553 stacking interactions; other site 526227001554 hinge regions; other site 526227001555 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 526227001556 oligomerisation interface [polypeptide binding]; other site 526227001557 mobile loop; other site 526227001558 roof hairpin; other site 526227001559 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 526227001560 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 526227001561 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 526227001562 Fumble; Region: Fumble; cl17357 526227001563 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 526227001564 CoA binding domain; Region: CoA_binding_2; pfam13380 526227001565 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 526227001566 CoA-ligase; Region: Ligase_CoA; pfam00549 526227001567 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 526227001568 hypothetical protein; Provisional; Region: PRK13685 526227001569 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227001570 metal ion-dependent adhesion site (MIDAS); other site 526227001571 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 526227001572 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 526227001573 active site 526227001574 dimer interface [polypeptide binding]; other site 526227001575 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 526227001576 dimer interface [polypeptide binding]; other site 526227001577 active site 526227001578 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 526227001579 active site 526227001580 NTP binding site [chemical binding]; other site 526227001581 metal binding triad [ion binding]; metal-binding site 526227001582 antibiotic binding site [chemical binding]; other site 526227001583 HEPN domain; Region: HEPN; cl00824 526227001584 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 526227001585 active site 526227001586 substrate-binding site [chemical binding]; other site 526227001587 metal-binding site [ion binding] 526227001588 GTP binding site [chemical binding]; other site 526227001589 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 526227001590 Ferritin-like domain; Region: Ferritin_2; pfam13668 526227001591 putative RNA polymerase sigma E protein; Provisional; Region: PRK13919 526227001592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526227001593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526227001594 DNA binding residues [nucleotide binding] 526227001595 Putative zinc-finger; Region: zf-HC2; pfam13490 526227001596 putative anti-sigmaE protein; Provisional; Region: PRK13920 526227001597 Anti-sigma-K factor rskA; Region: RskA; pfam10099 526227001598 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 526227001599 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 526227001600 UbiA prenyltransferase family; Region: UbiA; pfam01040 526227001601 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 526227001602 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 526227001603 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 526227001604 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 526227001605 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 526227001606 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 526227001607 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 526227001608 Subunit I/III interface [polypeptide binding]; other site 526227001609 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227001610 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 526227001611 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 526227001612 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 526227001613 active site 526227001614 Ribosomal protein L36e; Region: Ribosomal_L36e; cl02104 526227001615 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227001616 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 526227001617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227001618 S-adenosylmethionine binding site [chemical binding]; other site 526227001619 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227001620 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526227001621 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526227001622 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227001623 TM-ABC transporter signature motif; other site 526227001624 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227001625 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526227001626 TM-ABC transporter signature motif; other site 526227001627 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227001628 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526227001629 Cytochrome P450; Region: p450; cl12078 526227001630 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227001631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227001632 metal binding site [ion binding]; metal-binding site 526227001633 active site 526227001634 I-site; other site 526227001635 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 526227001636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227001637 S-adenosylmethionine binding site [chemical binding]; other site 526227001638 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 526227001639 nudix motif; other site 526227001640 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 526227001641 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 526227001642 DNA polymerase III subunit delta'; Validated; Region: PRK08485 526227001643 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 526227001644 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227001645 active site 526227001646 metal binding site [ion binding]; metal-binding site 526227001647 PBP superfamily domain; Region: PBP_like_2; cl17296 526227001648 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 526227001649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001650 dimer interface [polypeptide binding]; other site 526227001651 conserved gate region; other site 526227001652 putative PBP binding loops; other site 526227001653 ABC-ATPase subunit interface; other site 526227001654 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 526227001655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001656 putative PBP binding loops; other site 526227001657 ABC-ATPase subunit interface; other site 526227001658 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 526227001659 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 526227001660 Walker A/P-loop; other site 526227001661 ATP binding site [chemical binding]; other site 526227001662 Q-loop/lid; other site 526227001663 ABC transporter signature motif; other site 526227001664 Walker B; other site 526227001665 D-loop; other site 526227001666 H-loop/switch region; other site 526227001667 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 526227001668 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 526227001669 conserved cys residue [active] 526227001670 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 526227001671 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526227001672 GTP-binding protein YchF; Reviewed; Region: PRK09601 526227001673 YchF GTPase; Region: YchF; cd01900 526227001674 G1 box; other site 526227001675 GTP/Mg2+ binding site [chemical binding]; other site 526227001676 Switch I region; other site 526227001677 G2 box; other site 526227001678 Switch II region; other site 526227001679 G3 box; other site 526227001680 G4 box; other site 526227001681 G5 box; other site 526227001682 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 526227001683 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 526227001684 Kelch motif; Region: Kelch_1; pfam01344 526227001685 Kelch motif; Region: Kelch_6; pfam13964 526227001686 Kelch domain; Region: Kelch; smart00612 526227001687 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 526227001688 Kelch domain; Region: Kelch; smart00612 526227001689 Kelch motif; Region: Kelch_6; pfam13964 526227001690 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 526227001691 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227001692 TPR motif; other site 526227001693 binding surface 526227001694 FtsH Extracellular; Region: FtsH_ext; pfam06480 526227001695 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 526227001696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227001697 Walker A motif; other site 526227001698 ATP binding site [chemical binding]; other site 526227001699 Walker B motif; other site 526227001700 arginine finger; other site 526227001701 Peptidase family M41; Region: Peptidase_M41; pfam01434 526227001702 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 526227001703 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 526227001704 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 526227001705 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 526227001706 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 526227001707 homodimer interface [polypeptide binding]; other site 526227001708 substrate-cofactor binding pocket; other site 526227001709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227001710 catalytic residue [active] 526227001711 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 526227001712 putative active site [active] 526227001713 catalytic residue [active] 526227001714 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 526227001715 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 526227001716 5S rRNA interface [nucleotide binding]; other site 526227001717 CTC domain interface [polypeptide binding]; other site 526227001718 L16 interface [polypeptide binding]; other site 526227001719 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 526227001720 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 526227001721 active site 526227001722 homodimer interface [polypeptide binding]; other site 526227001723 catalytic site [active] 526227001724 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526227001725 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 526227001726 DNA interaction; other site 526227001727 Metal-binding active site; metal-binding site 526227001728 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526227001729 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 526227001730 putative NAD(P) binding site [chemical binding]; other site 526227001731 Trehalase; Region: Trehalase; cl17346 526227001732 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 526227001733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227001734 Walker A/P-loop; other site 526227001735 ATP binding site [chemical binding]; other site 526227001736 Q-loop/lid; other site 526227001737 ABC transporter signature motif; other site 526227001738 Walker B; other site 526227001739 D-loop; other site 526227001740 H-loop/switch region; other site 526227001741 TOBE domain; Region: TOBE_2; pfam08402 526227001742 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227001743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001744 dimer interface [polypeptide binding]; other site 526227001745 conserved gate region; other site 526227001746 putative PBP binding loops; other site 526227001747 ABC-ATPase subunit interface; other site 526227001748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001749 dimer interface [polypeptide binding]; other site 526227001750 conserved gate region; other site 526227001751 putative PBP binding loops; other site 526227001752 ABC-ATPase subunit interface; other site 526227001753 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227001754 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227001755 hypothetical protein; Provisional; Region: PRK11622 526227001756 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227001757 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227001758 DNA binding site [nucleotide binding] 526227001759 domain linker motif; other site 526227001760 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 526227001761 ligand binding site [chemical binding]; other site 526227001762 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 526227001763 FAD binding site [chemical binding]; other site 526227001764 short chain dehydrogenase; Provisional; Region: PRK12828 526227001765 classical (c) SDRs; Region: SDR_c; cd05233 526227001766 NAD(P) binding site [chemical binding]; other site 526227001767 active site 526227001768 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 526227001769 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 526227001770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 526227001771 Transposase; Region: HTH_Tnp_1; pfam01527 526227001772 putative transposase OrfB; Reviewed; Region: PHA02517 526227001773 Integrase core domain; Region: rve; pfam00665 526227001774 Integrase core domain; Region: rve_3; pfam13683 526227001775 Predicted integral membrane protein [Function unknown]; Region: COG5652 526227001776 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227001777 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 526227001778 dimer interface [polypeptide binding]; other site 526227001779 substrate binding site [chemical binding]; other site 526227001780 metal binding site [ion binding]; metal-binding site 526227001781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227001782 Probable transposase; Region: OrfB_IS605; pfam01385 526227001783 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227001784 OstA-like protein; Region: OstA; cl00844 526227001785 Predicted permeases [General function prediction only]; Region: COG0795 526227001786 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 526227001787 Predicted permeases [General function prediction only]; Region: COG0795 526227001788 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 526227001789 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 526227001790 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 526227001791 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 526227001792 FeoA domain; Region: FeoA; pfam04023 526227001793 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 526227001794 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526227001795 intersubunit interface [polypeptide binding]; other site 526227001796 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 526227001797 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 526227001798 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 526227001799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526227001800 ABC-ATPase subunit interface; other site 526227001801 dimer interface [polypeptide binding]; other site 526227001802 putative PBP binding regions; other site 526227001803 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526227001804 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 526227001805 ABC-ATPase subunit interface; other site 526227001806 dimer interface [polypeptide binding]; other site 526227001807 putative PBP binding regions; other site 526227001808 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 526227001809 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 526227001810 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 526227001811 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227001812 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 526227001813 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 526227001814 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 526227001815 xylose isomerase; Provisional; Region: PRK12677 526227001816 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 526227001817 active site 526227001818 catalytic residues [active] 526227001819 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 526227001820 D-xylulose kinase; Region: XylB; TIGR01312 526227001821 N- and C-terminal domain interface [polypeptide binding]; other site 526227001822 active site 526227001823 MgATP binding site [chemical binding]; other site 526227001824 catalytic site [active] 526227001825 metal binding site [ion binding]; metal-binding site 526227001826 xylulose binding site [chemical binding]; other site 526227001827 homodimer interface [polypeptide binding]; other site 526227001828 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 526227001829 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 526227001830 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 526227001831 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 526227001832 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 526227001833 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 526227001834 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 526227001835 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 526227001836 putative active site [active] 526227001837 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 526227001838 CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670 526227001839 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09747 526227001840 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 526227001841 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 526227001842 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 526227001843 CRISPR-associated protein, TIGR02710 family; Region: TIGR02710 526227001844 putative transposase OrfB; Reviewed; Region: PHA02517 526227001845 Integrase core domain; Region: rve; pfam00665 526227001846 Integrase core domain; Region: rve_3; pfam13683 526227001847 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 526227001848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227001849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227001850 homodimer interface [polypeptide binding]; other site 526227001851 catalytic residue [active] 526227001852 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 526227001853 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 526227001854 Walker A/P-loop; other site 526227001855 ATP binding site [chemical binding]; other site 526227001856 Q-loop/lid; other site 526227001857 ABC transporter signature motif; other site 526227001858 Walker B; other site 526227001859 D-loop; other site 526227001860 H-loop/switch region; other site 526227001861 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 526227001862 agmatinase; Region: agmatinase; TIGR01230 526227001863 oligomer interface [polypeptide binding]; other site 526227001864 putative active site [active] 526227001865 Mn binding site [ion binding]; other site 526227001866 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526227001867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227001868 non-specific DNA binding site [nucleotide binding]; other site 526227001869 salt bridge; other site 526227001870 sequence-specific DNA binding site [nucleotide binding]; other site 526227001871 Cupin domain; Region: Cupin_2; pfam07883 526227001872 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 526227001873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227001874 dimer interface [polypeptide binding]; other site 526227001875 conserved gate region; other site 526227001876 putative PBP binding loops; other site 526227001877 ABC-ATPase subunit interface; other site 526227001878 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 526227001879 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 526227001880 substrate binding pocket [chemical binding]; other site 526227001881 membrane-bound complex binding site; other site 526227001882 hinge residues; other site 526227001883 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 526227001884 active site 526227001885 AAA ATPase domain; Region: AAA_16; pfam13191 526227001886 Predicted ATPase [General function prediction only]; Region: COG3903 526227001887 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227001888 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227001889 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227001890 DNA binding residues [nucleotide binding] 526227001891 dimerization interface [polypeptide binding]; other site 526227001892 Cupin domain; Region: Cupin_2; cl17218 526227001893 putative transposase OrfB; Reviewed; Region: PHA02517 526227001894 Integrase core domain; Region: rve; pfam00665 526227001895 Integrase core domain; Region: rve_3; pfam13683 526227001896 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 526227001897 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227001898 ATP binding site [chemical binding]; other site 526227001899 Mg++ binding site [ion binding]; other site 526227001900 motif III; other site 526227001901 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227001902 nucleotide binding region [chemical binding]; other site 526227001903 ATP-binding site [chemical binding]; other site 526227001904 RNA-binding GUCT domain found in the RNA helicase II/Gu protein family; Region: GUCT; cl06960 526227001905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227001906 Coenzyme A binding pocket [chemical binding]; other site 526227001907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 526227001908 Coenzyme A binding pocket [chemical binding]; other site 526227001909 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 526227001910 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 526227001911 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227001912 FeS/SAM binding site; other site 526227001913 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 526227001914 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 526227001915 dimer interface [polypeptide binding]; other site 526227001916 substrate binding site [chemical binding]; other site 526227001917 metal binding sites [ion binding]; metal-binding site 526227001918 putative transposase OrfB; Reviewed; Region: PHA02517 526227001919 Integrase core domain; Region: rve; pfam00665 526227001920 Integrase core domain; Region: rve_3; pfam13683 526227001921 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 526227001922 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 526227001923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 526227001924 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 526227001925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 526227001926 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526227001927 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 526227001928 DNA-binding site [nucleotide binding]; DNA binding site 526227001929 FCD domain; Region: FCD; pfam07729 526227001930 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 526227001931 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526227001932 RNA binding surface [nucleotide binding]; other site 526227001933 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 526227001934 active site 526227001935 uracil binding [chemical binding]; other site 526227001936 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526227001937 dimerization interface [polypeptide binding]; other site 526227001938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227001939 dimer interface [polypeptide binding]; other site 526227001940 phosphorylation site [posttranslational modification] 526227001941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227001942 ATP binding site [chemical binding]; other site 526227001943 Mg2+ binding site [ion binding]; other site 526227001944 G-X-G motif; other site 526227001945 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227001946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227001947 active site 526227001948 phosphorylation site [posttranslational modification] 526227001949 intermolecular recognition site; other site 526227001950 dimerization interface [polypeptide binding]; other site 526227001951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227001952 DNA binding site [nucleotide binding] 526227001953 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 526227001954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227001955 putative substrate translocation pore; other site 526227001956 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227001957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227001958 Short C-terminal domain; Region: SHOCT; pfam09851 526227001959 Short C-terminal domain; Region: SHOCT; pfam09851 526227001960 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 526227001961 trimer interface [polypeptide binding]; other site 526227001962 active site 526227001963 agmatinase; Region: agmatinase; TIGR01230 526227001964 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 526227001965 putative active site [active] 526227001966 Mn binding site [ion binding]; other site 526227001967 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 526227001968 active site 526227001969 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 526227001970 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 526227001971 dimer interface [polypeptide binding]; other site 526227001972 motif 1; other site 526227001973 active site 526227001974 motif 2; other site 526227001975 motif 3; other site 526227001976 putative transposase OrfB; Reviewed; Region: PHA02517 526227001977 Integrase core domain; Region: rve; pfam00665 526227001978 Integrase core domain; Region: rve_3; pfam13683 526227001979 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 526227001980 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 526227001981 GTPase CgtA; Reviewed; Region: obgE; PRK12297 526227001982 GTP1/OBG; Region: GTP1_OBG; pfam01018 526227001983 Obg GTPase; Region: Obg; cd01898 526227001984 G1 box; other site 526227001985 GTP/Mg2+ binding site [chemical binding]; other site 526227001986 Switch I region; other site 526227001987 G2 box; other site 526227001988 G3 box; other site 526227001989 Switch II region; other site 526227001990 G4 box; other site 526227001991 G5 box; other site 526227001992 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 526227001993 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 526227001994 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 526227001995 active site 526227001996 (T/H)XGH motif; other site 526227001997 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227001998 Zn2+ binding site [ion binding]; other site 526227001999 Mg2+ binding site [ion binding]; other site 526227002000 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 526227002001 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 526227002002 Peptidase family M28; Region: Peptidase_M28; pfam04389 526227002003 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 526227002004 metal binding site [ion binding]; metal-binding site 526227002005 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 526227002006 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 526227002007 Walker A motif; other site 526227002008 ATP binding site [chemical binding]; other site 526227002009 Walker B motif; other site 526227002010 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 526227002011 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 526227002012 intersubunit interface [polypeptide binding]; other site 526227002013 active site 526227002014 zinc binding site [ion binding]; other site 526227002015 Na+ binding site [ion binding]; other site 526227002016 AAA ATPase domain; Region: AAA_16; pfam13191 526227002017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227002018 TPR motif; other site 526227002019 binding surface 526227002020 TPR repeat; Region: TPR_11; pfam13414 526227002021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227002022 binding surface 526227002023 TPR motif; other site 526227002024 TPR repeat; Region: TPR_11; pfam13414 526227002025 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227002026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227002027 binding surface 526227002028 TPR motif; other site 526227002029 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227002030 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227002031 active site 526227002032 catalytic residues [active] 526227002033 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 526227002034 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 526227002035 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 526227002036 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 526227002037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227002038 active site 526227002039 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 526227002040 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 526227002041 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 526227002042 homotetramer interface [polypeptide binding]; other site 526227002043 ligand binding site [chemical binding]; other site 526227002044 catalytic site [active] 526227002045 NAD binding site [chemical binding]; other site 526227002046 S-ribosylhomocysteinase; Provisional; Region: PRK02260 526227002047 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 526227002048 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 526227002049 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 526227002050 TrkA-N domain; Region: TrkA_N; pfam02254 526227002051 TrkA-C domain; Region: TrkA_C; pfam02080 526227002052 TrkA-N domain; Region: TrkA_N; pfam02254 526227002053 TrkA-C domain; Region: TrkA_C; pfam02080 526227002054 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 526227002055 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 526227002056 EamA-like transporter family; Region: EamA; pfam00892 526227002057 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 526227002058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227002059 non-specific DNA binding site [nucleotide binding]; other site 526227002060 salt bridge; other site 526227002061 sequence-specific DNA binding site [nucleotide binding]; other site 526227002062 PEGA domain; Region: PEGA; pfam08308 526227002063 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 526227002064 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 526227002065 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 526227002066 Phosphotransferase enzyme family; Region: APH; pfam01636 526227002067 Fructosamine kinase; Region: Fructosamin_kin; cl17579 526227002068 Low molecular weight phosphatase family; Region: LMWPc; cd00115 526227002069 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 526227002070 active site 526227002071 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 526227002072 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 526227002073 active site 526227002074 catalytic site [active] 526227002075 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 526227002076 putative transposase OrfB; Reviewed; Region: PHA02517 526227002077 Integrase core domain; Region: rve; pfam00665 526227002078 Integrase core domain; Region: rve_3; pfam13683 526227002079 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 526227002080 FAD binding domain; Region: FAD_binding_4; pfam01565 526227002081 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 526227002082 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526227002083 active site 526227002084 catalytic tetrad [active] 526227002085 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 526227002086 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 526227002087 Predicted transcriptional regulators [Transcription]; Region: COG1733 526227002088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227002089 dimerization interface [polypeptide binding]; other site 526227002090 putative DNA binding site [nucleotide binding]; other site 526227002091 putative Zn2+ binding site [ion binding]; other site 526227002092 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 526227002093 NADH(P)-binding; Region: NAD_binding_10; pfam13460 526227002094 NAD binding site [chemical binding]; other site 526227002095 substrate binding site [chemical binding]; other site 526227002096 putative active site [active] 526227002097 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526227002098 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227002099 active site 526227002100 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 526227002101 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 526227002102 active site 526227002103 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227002104 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526227002105 Walker A/P-loop; other site 526227002106 ATP binding site [chemical binding]; other site 526227002107 Q-loop/lid; other site 526227002108 ABC transporter signature motif; other site 526227002109 Walker B; other site 526227002110 D-loop; other site 526227002111 H-loop/switch region; other site 526227002112 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 526227002113 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 526227002114 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227002115 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 526227002116 Walker A/P-loop; other site 526227002117 ATP binding site [chemical binding]; other site 526227002118 Q-loop/lid; other site 526227002119 ABC transporter signature motif; other site 526227002120 Walker B; other site 526227002121 D-loop; other site 526227002122 H-loop/switch region; other site 526227002123 Predicted transcriptional regulators [Transcription]; Region: COG1725 526227002124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227002125 DNA-binding site [nucleotide binding]; DNA binding site 526227002126 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 526227002127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227002128 Walker A/P-loop; other site 526227002129 ATP binding site [chemical binding]; other site 526227002130 Q-loop/lid; other site 526227002131 ABC transporter signature motif; other site 526227002132 Walker B; other site 526227002133 D-loop; other site 526227002134 H-loop/switch region; other site 526227002135 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227002136 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227002137 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 526227002138 HlyD family secretion protein; Region: HlyD_3; pfam13437 526227002139 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526227002140 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 526227002141 Walker A/P-loop; other site 526227002142 ATP binding site [chemical binding]; other site 526227002143 Q-loop/lid; other site 526227002144 ABC transporter signature motif; other site 526227002145 Walker B; other site 526227002146 D-loop; other site 526227002147 H-loop/switch region; other site 526227002148 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227002149 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 526227002150 FtsX-like permease family; Region: FtsX; pfam02687 526227002151 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526227002152 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526227002153 active site 526227002154 catalytic tetrad [active] 526227002155 AAA domain; Region: AAA_32; pfam13654 526227002156 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 526227002157 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 526227002158 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 526227002159 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 526227002160 ligand binding site; other site 526227002161 oligomer interface; other site 526227002162 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 526227002163 dimer interface [polypeptide binding]; other site 526227002164 N-terminal domain interface [polypeptide binding]; other site 526227002165 sulfate 1 binding site; other site 526227002166 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 526227002167 NADPH bind site [chemical binding]; other site 526227002168 putative FMN binding site [chemical binding]; other site 526227002169 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227002170 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 526227002171 putative active site pocket [active] 526227002172 dimerization interface [polypeptide binding]; other site 526227002173 putative catalytic residue [active] 526227002174 glycogen synthase; Provisional; Region: glgA; PRK00654 526227002175 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 526227002176 ADP-binding pocket [chemical binding]; other site 526227002177 homodimer interface [polypeptide binding]; other site 526227002178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227002179 binding surface 526227002180 Tetratricopeptide repeat; Region: TPR_16; pfam13432 526227002181 TPR motif; other site 526227002182 TPR repeat; Region: TPR_11; pfam13414 526227002183 Predicted membrane protein [Function unknown]; Region: COG2323 526227002184 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 526227002185 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526227002186 Coenzyme A binding pocket [chemical binding]; other site 526227002187 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 526227002188 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 526227002189 NMT1/THI5 like; Region: NMT1; pfam09084 526227002190 substrate binding pocket [chemical binding]; other site 526227002191 membrane-bound complex binding site; other site 526227002192 hinge residues; other site 526227002193 SWIM zinc finger; Region: SWIM; pfam04434 526227002194 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 526227002195 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 526227002196 Walker A/P-loop; other site 526227002197 ATP binding site [chemical binding]; other site 526227002198 Q-loop/lid; other site 526227002199 ABC transporter signature motif; other site 526227002200 Walker B; other site 526227002201 D-loop; other site 526227002202 H-loop/switch region; other site 526227002203 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 526227002204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002205 dimer interface [polypeptide binding]; other site 526227002206 conserved gate region; other site 526227002207 putative PBP binding loops; other site 526227002208 ABC-ATPase subunit interface; other site 526227002209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227002210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227002211 dimer interface [polypeptide binding]; other site 526227002212 phosphorylation site [posttranslational modification] 526227002213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227002214 Mg2+ binding site [ion binding]; other site 526227002215 G-X-G motif; other site 526227002216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227002217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002218 active site 526227002219 phosphorylation site [posttranslational modification] 526227002220 intermolecular recognition site; other site 526227002221 dimerization interface [polypeptide binding]; other site 526227002222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227002223 DNA binding site [nucleotide binding] 526227002224 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 526227002225 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 526227002226 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 526227002227 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 526227002228 RPB12 interaction site [polypeptide binding]; other site 526227002229 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 526227002230 RPB10 interaction site [polypeptide binding]; other site 526227002231 RPB1 interaction site [polypeptide binding]; other site 526227002232 RPB11 interaction site [polypeptide binding]; other site 526227002233 RPB3 interaction site [polypeptide binding]; other site 526227002234 RPB12 interaction site [polypeptide binding]; other site 526227002235 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 526227002236 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 526227002237 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 526227002238 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 526227002239 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 526227002240 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 526227002241 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 526227002242 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 526227002243 G-loop; other site 526227002244 DNA binding site [nucleotide binding] 526227002245 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 526227002246 active site 526227002247 intersubunit interface [polypeptide binding]; other site 526227002248 Zn2+ binding site [ion binding]; other site 526227002249 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526227002250 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 526227002251 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 526227002252 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 526227002253 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227002254 dimer interface [polypeptide binding]; other site 526227002255 ssDNA binding site [nucleotide binding]; other site 526227002256 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227002257 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 526227002258 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227002259 dimer interface [polypeptide binding]; other site 526227002260 ssDNA binding site [nucleotide binding]; other site 526227002261 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227002262 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 526227002263 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 526227002264 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 526227002265 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 526227002266 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 526227002267 lipoyl synthase; Provisional; Region: PRK05481 526227002268 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227002269 FeS/SAM binding site; other site 526227002270 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 526227002271 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 526227002272 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 526227002273 Ca binding site [ion binding]; other site 526227002274 active site 526227002275 catalytic site [active] 526227002276 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 526227002277 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 526227002278 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 526227002279 Family description; Region: VCBS; pfam13517 526227002280 Family description; Region: VCBS; pfam13517 526227002281 Family description; Region: VCBS; pfam13517 526227002282 Family description; Region: VCBS; pfam13517 526227002283 Family description; Region: VCBS; pfam13517 526227002284 Trehalose utilisation; Region: ThuA; pfam06283 526227002285 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227002286 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227002287 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 526227002288 PhoU domain; Region: PhoU; pfam01895 526227002289 PhoU domain; Region: PhoU; pfam01895 526227002290 PAS domain S-box; Region: sensory_box; TIGR00229 526227002291 PAS domain; Region: PAS_8; pfam13188 526227002292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227002293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227002294 dimer interface [polypeptide binding]; other site 526227002295 phosphorylation site [posttranslational modification] 526227002296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227002297 ATP binding site [chemical binding]; other site 526227002298 Mg2+ binding site [ion binding]; other site 526227002299 G-X-G motif; other site 526227002300 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227002301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002302 active site 526227002303 phosphorylation site [posttranslational modification] 526227002304 intermolecular recognition site; other site 526227002305 dimerization interface [polypeptide binding]; other site 526227002306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227002307 DNA binding site [nucleotide binding] 526227002308 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 526227002309 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 526227002310 active site 526227002311 PHP Thumb interface [polypeptide binding]; other site 526227002312 metal binding site [ion binding]; metal-binding site 526227002313 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 526227002314 generic binding surface II; other site 526227002315 generic binding surface I; other site 526227002316 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 526227002317 metal binding site 2 [ion binding]; metal-binding site 526227002318 putative DNA binding helix; other site 526227002319 metal binding site 1 [ion binding]; metal-binding site 526227002320 dimer interface [polypeptide binding]; other site 526227002321 structural Zn2+ binding site [ion binding]; other site 526227002322 multifunctional aminopeptidase A; Provisional; Region: PRK00913 526227002323 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 526227002324 interface (dimer of trimers) [polypeptide binding]; other site 526227002325 Substrate-binding/catalytic site; other site 526227002326 Zn-binding sites [ion binding]; other site 526227002327 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 526227002328 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 526227002329 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 526227002330 Ligand Binding Site [chemical binding]; other site 526227002331 Caa3-Type Cytochrome Oxidase subunit 4 interacts with cyt c subunits I/III; Region: Caa3-IV; cd12222 526227002332 dimer interface [polypeptide binding]; other site 526227002333 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 526227002334 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 526227002335 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 526227002336 competence damage-inducible protein A; Provisional; Region: PRK00549 526227002337 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 526227002338 putative MPT binding site; other site 526227002339 Competence-damaged protein; Region: CinA; pfam02464 526227002340 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 526227002341 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 526227002342 recombinase A; Provisional; Region: recA; PRK09354 526227002343 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 526227002344 hexamer interface [polypeptide binding]; other site 526227002345 Walker A motif; other site 526227002346 ATP binding site [chemical binding]; other site 526227002347 Walker B motif; other site 526227002348 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 526227002349 hypothetical protein; Provisional; Region: PRK12705 526227002350 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227002351 Zn2+ binding site [ion binding]; other site 526227002352 Mg2+ binding site [ion binding]; other site 526227002353 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227002354 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 526227002355 P-loop; other site 526227002356 Magnesium ion binding site [ion binding]; other site 526227002357 rod shape-determining protein MreB; Provisional; Region: PRK13927 526227002358 MreB and similar proteins; Region: MreB_like; cd10225 526227002359 nucleotide binding site [chemical binding]; other site 526227002360 Mg binding site [ion binding]; other site 526227002361 putative protofilament interaction site [polypeptide binding]; other site 526227002362 RodZ interaction site [polypeptide binding]; other site 526227002363 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 526227002364 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 526227002365 putative trimer interface [polypeptide binding]; other site 526227002366 putative CoA binding site [chemical binding]; other site 526227002367 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 526227002368 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 526227002369 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227002370 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526227002371 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 526227002372 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 526227002373 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 526227002374 active site 526227002375 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 526227002376 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 526227002377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227002378 Walker A/P-loop; other site 526227002379 ATP binding site [chemical binding]; other site 526227002380 Q-loop/lid; other site 526227002381 ABC transporter signature motif; other site 526227002382 Walker B; other site 526227002383 D-loop; other site 526227002384 H-loop/switch region; other site 526227002385 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227002386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227002387 dimerization interface [polypeptide binding]; other site 526227002388 DNA binding residues [nucleotide binding] 526227002389 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 526227002390 catalytic residues [active] 526227002391 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 526227002392 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227002393 MULE transposase domain; Region: MULE; pfam10551 526227002394 CCC1-related family of proteins; Region: CCC1_like; cl00278 526227002395 putative transposase OrfB; Reviewed; Region: PHA02517 526227002396 Integrase core domain; Region: rve; pfam00665 526227002397 Integrase core domain; Region: rve_3; pfam13683 526227002398 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 526227002399 Esterase/lipase [General function prediction only]; Region: COG1647 526227002400 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 526227002401 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 526227002402 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 526227002403 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 526227002404 Flavoprotein; Region: Flavoprotein; pfam02441 526227002405 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 526227002406 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 526227002407 substrate binding site; other site 526227002408 dimer interface; other site 526227002409 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612 526227002410 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526227002411 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 526227002412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002413 dimer interface [polypeptide binding]; other site 526227002414 conserved gate region; other site 526227002415 ABC-ATPase subunit interface; other site 526227002416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002417 dimer interface [polypeptide binding]; other site 526227002418 conserved gate region; other site 526227002419 putative PBP binding loops; other site 526227002420 ABC-ATPase subunit interface; other site 526227002421 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 526227002422 putative active site [active] 526227002423 putative transposase OrfB; Reviewed; Region: PHA02517 526227002424 Integrase core domain; Region: rve; pfam00665 526227002425 Integrase core domain; Region: rve_3; pfam13683 526227002426 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227002427 metal binding site [ion binding]; metal-binding site 526227002428 active site 526227002429 I-site; other site 526227002430 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526227002431 putative RNA polymerase sigma E protein; Provisional; Region: PRK13919 526227002432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526227002433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526227002434 DNA binding residues [nucleotide binding] 526227002435 Putative zinc-finger; Region: zf-HC2; pfam13490 526227002436 putative anti-sigmaE protein; Provisional; Region: PRK13920 526227002437 Anti-sigma-K factor rskA; Region: RskA; pfam10099 526227002438 glutamate carboxypeptidase; Reviewed; Region: PRK06133 526227002439 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 526227002440 metal binding site [ion binding]; metal-binding site 526227002441 dimer interface [polypeptide binding]; other site 526227002442 putative transposase OrfB; Reviewed; Region: PHA02517 526227002443 Integrase core domain; Region: rve; pfam00665 526227002444 Integrase core domain; Region: rve_3; pfam13683 526227002445 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 526227002446 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 526227002447 oligomeric interface; other site 526227002448 putative active site [active] 526227002449 homodimer interface [polypeptide binding]; other site 526227002450 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 526227002451 putative deacylase active site [active] 526227002452 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 526227002453 active site 526227002454 Zn2+ binding site [ion binding]; other site 526227002455 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526227002456 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526227002457 NAD(P) binding site [chemical binding]; other site 526227002458 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 526227002459 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 526227002460 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 526227002461 CoA-transferase family III; Region: CoA_transf_3; pfam02515 526227002462 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227002463 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227002464 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 526227002465 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 526227002466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227002467 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 526227002468 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 526227002469 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 526227002470 Walker A/P-loop; other site 526227002471 ATP binding site [chemical binding]; other site 526227002472 Q-loop/lid; other site 526227002473 ABC transporter signature motif; other site 526227002474 Walker B; other site 526227002475 D-loop; other site 526227002476 H-loop/switch region; other site 526227002477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002478 ABC-ATPase subunit interface; other site 526227002479 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 526227002480 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 526227002481 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526227002482 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227002483 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526227002484 Walker A/P-loop; other site 526227002485 ATP binding site [chemical binding]; other site 526227002486 Q-loop/lid; other site 526227002487 ABC transporter signature motif; other site 526227002488 Walker B; other site 526227002489 D-loop; other site 526227002490 H-loop/switch region; other site 526227002491 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 526227002492 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 526227002493 trimer interface [polypeptide binding]; other site 526227002494 dimer interface [polypeptide binding]; other site 526227002495 putative active site [active] 526227002496 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227002497 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227002498 active site 526227002499 metal binding site [ion binding]; metal-binding site 526227002500 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 526227002501 putative active site [active] 526227002502 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 526227002503 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 526227002504 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 526227002505 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 526227002506 putative catalytic residue [active] 526227002507 Copper resistance protein D; Region: CopD; pfam05425 526227002508 CopC domain; Region: CopC; cl01012 526227002509 Protein of unknown function (DUF461); Region: DUF461; pfam04314 526227002510 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 526227002511 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 526227002512 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 526227002513 trimer interface [polypeptide binding]; other site 526227002514 putative metal binding site [ion binding]; other site 526227002515 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 526227002516 active site 526227002517 Ap6A binding site [chemical binding]; other site 526227002518 nudix motif; other site 526227002519 metal binding site [ion binding]; metal-binding site 526227002520 Uncharacterized conserved protein [Function unknown]; Region: COG3342 526227002521 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 526227002522 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 526227002523 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 526227002524 Thiamine pyrophosphokinase; Region: TPK; cd07995 526227002525 active site 526227002526 thiamine binding site [chemical binding]; other site 526227002527 dimerization interface [polypeptide binding]; other site 526227002528 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227002529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227002530 Walker A/P-loop; other site 526227002531 ATP binding site [chemical binding]; other site 526227002532 Q-loop/lid; other site 526227002533 ABC transporter signature motif; other site 526227002534 Walker B; other site 526227002535 D-loop; other site 526227002536 H-loop/switch region; other site 526227002537 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 526227002538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002539 active site 526227002540 phosphorylation site [posttranslational modification] 526227002541 intermolecular recognition site; other site 526227002542 dimerization interface [polypeptide binding]; other site 526227002543 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526227002544 GAF domain; Region: GAF_3; pfam13492 526227002545 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 526227002546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526227002547 putative active site [active] 526227002548 heme pocket [chemical binding]; other site 526227002549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227002550 dimer interface [polypeptide binding]; other site 526227002551 phosphorylation site [posttranslational modification] 526227002552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227002553 ATP binding site [chemical binding]; other site 526227002554 Mg2+ binding site [ion binding]; other site 526227002555 G-X-G motif; other site 526227002556 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 526227002557 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 526227002558 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 526227002559 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526227002560 Walker A/P-loop; other site 526227002561 ATP binding site [chemical binding]; other site 526227002562 Q-loop/lid; other site 526227002563 ABC transporter signature motif; other site 526227002564 Walker B; other site 526227002565 D-loop; other site 526227002566 H-loop/switch region; other site 526227002567 CcmB protein; Region: CcmB; cl17444 526227002568 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 526227002569 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 526227002570 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 526227002571 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 526227002572 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 526227002573 catalytic residues [active] 526227002574 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 526227002575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227002576 binding surface 526227002577 Tetratricopeptide repeat; Region: TPR_16; pfam13432 526227002578 TPR motif; other site 526227002579 Tetratricopeptide repeat; Region: TPR_16; pfam13432 526227002580 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 526227002581 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 526227002582 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 526227002583 iron-sulfur cluster [ion binding]; other site 526227002584 [2Fe-2S] cluster binding site [ion binding]; other site 526227002585 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 526227002586 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 526227002587 active site 526227002588 HIGH motif; other site 526227002589 dimer interface [polypeptide binding]; other site 526227002590 KMSKS motif; other site 526227002591 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526227002592 RNA binding surface [nucleotide binding]; other site 526227002593 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 526227002594 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 526227002595 homoserine kinase; Provisional; Region: PRK01212 526227002596 Uncharacterized conserved protein [Function unknown]; Region: COG0062 526227002597 putative carbohydrate kinase; Provisional; Region: PRK10565 526227002598 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 526227002599 putative substrate binding site [chemical binding]; other site 526227002600 putative ATP binding site [chemical binding]; other site 526227002601 NAD-dependent deacetylase; Provisional; Region: PRK00481 526227002602 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 526227002603 NAD+ binding site [chemical binding]; other site 526227002604 substrate binding site [chemical binding]; other site 526227002605 Zn binding site [ion binding]; other site 526227002606 GTP-binding protein Der; Reviewed; Region: PRK00093 526227002607 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 526227002608 G1 box; other site 526227002609 GTP/Mg2+ binding site [chemical binding]; other site 526227002610 Switch I region; other site 526227002611 G2 box; other site 526227002612 Switch II region; other site 526227002613 G3 box; other site 526227002614 G4 box; other site 526227002615 G5 box; other site 526227002616 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 526227002617 G1 box; other site 526227002618 GTP/Mg2+ binding site [chemical binding]; other site 526227002619 Switch I region; other site 526227002620 G2 box; other site 526227002621 G3 box; other site 526227002622 Switch II region; other site 526227002623 G4 box; other site 526227002624 G5 box; other site 526227002625 DinB family; Region: DinB; cl17821 526227002626 DinB superfamily; Region: DinB_2; pfam12867 526227002627 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227002628 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526227002629 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227002630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002631 dimer interface [polypeptide binding]; other site 526227002632 conserved gate region; other site 526227002633 putative PBP binding loops; other site 526227002634 ABC-ATPase subunit interface; other site 526227002635 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 526227002636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002637 ABC-ATPase subunit interface; other site 526227002638 putative PBP binding loops; other site 526227002639 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 526227002640 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 526227002641 putative acyl-acceptor binding pocket; other site 526227002642 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 526227002643 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 526227002644 dimer interface [polypeptide binding]; other site 526227002645 active site 526227002646 glycine-pyridoxal phosphate binding site [chemical binding]; other site 526227002647 folate binding site [chemical binding]; other site 526227002648 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227002649 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227002650 FOG: CBS domain [General function prediction only]; Region: COG0517 526227002651 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 526227002652 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 526227002653 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 526227002654 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 526227002655 active site 526227002656 Zn binding site [ion binding]; other site 526227002657 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 526227002658 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 526227002659 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 526227002660 Phosphotransferase enzyme family; Region: APH; pfam01636 526227002661 active site 526227002662 ATP binding site [chemical binding]; other site 526227002663 antibiotic binding site [chemical binding]; other site 526227002664 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 526227002665 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227002666 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 526227002667 active site 526227002668 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 526227002669 short chain dehydrogenase; Provisional; Region: PRK08339 526227002670 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 526227002671 putative NAD(P) binding site [chemical binding]; other site 526227002672 putative active site [active] 526227002673 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526227002674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227002675 Coenzyme A binding pocket [chemical binding]; other site 526227002676 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 526227002677 DNA-binding site [nucleotide binding]; DNA binding site 526227002678 RNA-binding motif; other site 526227002679 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 526227002680 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 526227002681 HSP70 interaction site [polypeptide binding]; other site 526227002682 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 526227002683 Zn binding sites [ion binding]; other site 526227002684 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 526227002685 dimer interface [polypeptide binding]; other site 526227002686 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 526227002687 trehalose synthase; Region: treS_nterm; TIGR02456 526227002688 active site 526227002689 catalytic site [active] 526227002690 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 526227002691 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526227002692 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 526227002693 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227002694 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227002695 catalytic residue [active] 526227002696 recombination factor protein RarA; Reviewed; Region: PRK13342 526227002697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227002698 Walker A motif; other site 526227002699 ATP binding site [chemical binding]; other site 526227002700 Walker B motif; other site 526227002701 arginine finger; other site 526227002702 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 526227002703 PaaX-like protein; Region: PaaX; pfam07848 526227002704 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 526227002705 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 526227002706 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 526227002707 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 526227002708 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 526227002709 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 526227002710 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 526227002711 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 526227002712 active site 526227002713 dimer interface [polypeptide binding]; other site 526227002714 motif 1; other site 526227002715 motif 2; other site 526227002716 motif 3; other site 526227002717 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 526227002718 anticodon binding site; other site 526227002719 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 526227002720 ATP-binding site [chemical binding]; other site 526227002721 Gluconate-6-phosphate binding site [chemical binding]; other site 526227002722 Shikimate kinase; Region: SKI; pfam01202 526227002723 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 526227002724 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 526227002725 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 526227002726 Active site serine [active] 526227002727 Putative cyclase; Region: Cyclase; cl00814 526227002728 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 526227002729 active site 526227002730 Fe-S cluster binding site [ion binding]; other site 526227002731 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227002732 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 526227002733 4Fe-4S binding domain; Region: Fer4; pfam00037 526227002734 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526227002735 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 526227002736 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 526227002737 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 526227002738 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 526227002739 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 526227002740 DNA binding site [nucleotide binding] 526227002741 active site 526227002742 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 526227002743 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227002744 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526227002745 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526227002746 KduI/IolB family; Region: KduI; pfam04962 526227002747 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 526227002748 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 526227002749 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 526227002750 phosphoenolpyruvate synthase; Validated; Region: PRK06464 526227002751 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 526227002752 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 526227002753 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 526227002754 PEP synthetase regulatory protein; Provisional; Region: PRK05339 526227002755 phytoene desaturase; Region: crtI_fam; TIGR02734 526227002756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526227002757 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 526227002758 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 526227002759 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 526227002760 Walker A/P-loop; other site 526227002761 ATP binding site [chemical binding]; other site 526227002762 Q-loop/lid; other site 526227002763 ABC transporter signature motif; other site 526227002764 Walker B; other site 526227002765 D-loop; other site 526227002766 H-loop/switch region; other site 526227002767 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 526227002768 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 526227002769 trimerization site [polypeptide binding]; other site 526227002770 active site 526227002771 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 526227002772 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 526227002773 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227002774 catalytic residue [active] 526227002775 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 526227002776 [2Fe-2S] cluster binding site [ion binding]; other site 526227002777 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 526227002778 FeS assembly protein SufD; Region: sufD; TIGR01981 526227002779 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 526227002780 FeS assembly protein SufB; Region: sufB; TIGR01980 526227002781 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 526227002782 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 526227002783 Walker A/P-loop; other site 526227002784 ATP binding site [chemical binding]; other site 526227002785 Q-loop/lid; other site 526227002786 ABC transporter signature motif; other site 526227002787 Walker B; other site 526227002788 D-loop; other site 526227002789 H-loop/switch region; other site 526227002790 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 526227002791 isocitrate lyase; Provisional; Region: PRK15063 526227002792 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 526227002793 tetramer interface [polypeptide binding]; other site 526227002794 active site 526227002795 Mg2+/Mn2+ binding site [ion binding]; other site 526227002796 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526227002797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227002798 DNA-binding site [nucleotide binding]; DNA binding site 526227002799 FCD domain; Region: FCD; pfam07729 526227002800 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 526227002801 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 526227002802 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 526227002803 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 526227002804 ligand binding site [chemical binding]; other site 526227002805 NAD binding site [chemical binding]; other site 526227002806 dimerization interface [polypeptide binding]; other site 526227002807 catalytic site [active] 526227002808 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 526227002809 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227002810 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227002811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002812 dimer interface [polypeptide binding]; other site 526227002813 putative PBP binding loops; other site 526227002814 ABC-ATPase subunit interface; other site 526227002815 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227002816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227002817 dimer interface [polypeptide binding]; other site 526227002818 conserved gate region; other site 526227002819 putative PBP binding loops; other site 526227002820 ABC-ATPase subunit interface; other site 526227002821 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 526227002822 trimer interface [polypeptide binding]; other site 526227002823 hexamer (dimer of trimers) interface [polypeptide binding]; other site 526227002824 substrate binding site [chemical binding]; other site 526227002825 Mn binding site [ion binding]; other site 526227002826 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526227002827 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 526227002828 substrate binding site [chemical binding]; other site 526227002829 ATP binding site [chemical binding]; other site 526227002830 Class I aldolases; Region: Aldolase_Class_I; cl17187 526227002831 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 526227002832 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 526227002833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526227002834 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 526227002835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526227002836 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227002837 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 526227002838 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 526227002839 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227002840 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526227002841 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526227002842 glycerol kinase; Provisional; Region: glpK; PRK00047 526227002843 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 526227002844 N- and C-terminal domain interface [polypeptide binding]; other site 526227002845 active site 526227002846 MgATP binding site [chemical binding]; other site 526227002847 catalytic site [active] 526227002848 metal binding site [ion binding]; metal-binding site 526227002849 glycerol binding site [chemical binding]; other site 526227002850 homotetramer interface [polypeptide binding]; other site 526227002851 homodimer interface [polypeptide binding]; other site 526227002852 FBP binding site [chemical binding]; other site 526227002853 protein IIAGlc interface [polypeptide binding]; other site 526227002854 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 526227002855 heme-binding site [chemical binding]; other site 526227002856 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 526227002857 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 526227002858 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 526227002859 HIGH motif; other site 526227002860 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 526227002861 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526227002862 active site 526227002863 KMSKS motif; other site 526227002864 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 526227002865 tRNA binding surface [nucleotide binding]; other site 526227002866 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227002867 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227002868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002869 active site 526227002870 phosphorylation site [posttranslational modification] 526227002871 intermolecular recognition site; other site 526227002872 dimerization interface [polypeptide binding]; other site 526227002873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227002874 DNA binding site [nucleotide binding] 526227002875 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 526227002876 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 526227002877 FMN binding site [chemical binding]; other site 526227002878 active site 526227002879 catalytic residues [active] 526227002880 substrate binding site [chemical binding]; other site 526227002881 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 526227002882 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 526227002883 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 526227002884 DNA protecting protein DprA; Region: dprA; TIGR00732 526227002885 GTPase Era; Reviewed; Region: era; PRK00089 526227002886 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 526227002887 G1 box; other site 526227002888 GTP/Mg2+ binding site [chemical binding]; other site 526227002889 Switch I region; other site 526227002890 G2 box; other site 526227002891 Switch II region; other site 526227002892 G3 box; other site 526227002893 G4 box; other site 526227002894 G5 box; other site 526227002895 KH domain; Region: KH_2; pfam07650 526227002896 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 526227002897 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 526227002898 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 526227002899 trimer interface [polypeptide binding]; other site 526227002900 active site 526227002901 substrate binding site [chemical binding]; other site 526227002902 CoA binding site [chemical binding]; other site 526227002903 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526227002904 Predicted ATPase [General function prediction only]; Region: COG3899 526227002905 AAA ATPase domain; Region: AAA_16; pfam13191 526227002906 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227002907 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227002908 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 526227002909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526227002910 Histidine kinase; Region: HisKA_3; pfam07730 526227002911 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 526227002912 ATP binding site [chemical binding]; other site 526227002913 G-X-G motif; other site 526227002914 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227002915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002916 active site 526227002917 phosphorylation site [posttranslational modification] 526227002918 intermolecular recognition site; other site 526227002919 dimerization interface [polypeptide binding]; other site 526227002920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227002921 DNA binding residues [nucleotide binding] 526227002922 dimerization interface [polypeptide binding]; other site 526227002923 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 526227002924 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 526227002925 active site 526227002926 tetramer interface [polypeptide binding]; other site 526227002927 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227002928 active site 526227002929 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 526227002930 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 526227002931 dimerization interface [polypeptide binding]; other site 526227002932 ATP binding site [chemical binding]; other site 526227002933 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 526227002934 dimerization interface [polypeptide binding]; other site 526227002935 ATP binding site [chemical binding]; other site 526227002936 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 526227002937 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 526227002938 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 526227002939 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 526227002940 putative active site [active] 526227002941 catalytic triad [active] 526227002942 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 526227002943 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 526227002944 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 526227002945 ATP binding site [chemical binding]; other site 526227002946 active site 526227002947 substrate binding site [chemical binding]; other site 526227002948 adenylosuccinate lyase; Provisional; Region: PRK07492 526227002949 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 526227002950 tetramer interface [polypeptide binding]; other site 526227002951 active site 526227002952 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227002953 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 526227002954 FtsX-like permease family; Region: FtsX; pfam02687 526227002955 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526227002956 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 526227002957 Walker A/P-loop; other site 526227002958 ATP binding site [chemical binding]; other site 526227002959 Q-loop/lid; other site 526227002960 ABC transporter signature motif; other site 526227002961 Walker B; other site 526227002962 D-loop; other site 526227002963 H-loop/switch region; other site 526227002964 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 526227002965 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 526227002966 HlyD family secretion protein; Region: HlyD_3; pfam13437 526227002967 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 526227002968 Outer membrane efflux protein; Region: OEP; pfam02321 526227002969 Outer membrane efflux protein; Region: OEP; pfam02321 526227002970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227002971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227002972 active site 526227002973 phosphorylation site [posttranslational modification] 526227002974 intermolecular recognition site; other site 526227002975 dimerization interface [polypeptide binding]; other site 526227002976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227002977 DNA binding site [nucleotide binding] 526227002978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526227002979 dimerization interface [polypeptide binding]; other site 526227002980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227002981 dimer interface [polypeptide binding]; other site 526227002982 phosphorylation site [posttranslational modification] 526227002983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227002984 ATP binding site [chemical binding]; other site 526227002985 Mg2+ binding site [ion binding]; other site 526227002986 G-X-G motif; other site 526227002987 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 526227002988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227002989 motif II; other site 526227002990 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 526227002991 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 526227002992 nudix motif; other site 526227002993 putative transposase OrfB; Reviewed; Region: PHA02517 526227002994 Integrase core domain; Region: rve; pfam00665 526227002995 Integrase core domain; Region: rve_3; pfam13683 526227002996 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 526227002997 DNA-binding site [nucleotide binding]; DNA binding site 526227002998 RNA-binding motif; other site 526227002999 Fatty acid desaturase; Region: FA_desaturase; pfam00487 526227003000 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 526227003001 putative di-iron ligands [ion binding]; other site 526227003002 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 526227003003 Tetratricopeptide repeat; Region: TPR_16; pfam13432 526227003004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227003005 binding surface 526227003006 TPR motif; other site 526227003007 TPR repeat; Region: TPR_11; pfam13414 526227003008 Predicted membrane protein [Function unknown]; Region: COG2860 526227003009 UPF0126 domain; Region: UPF0126; pfam03458 526227003010 UPF0126 domain; Region: UPF0126; pfam03458 526227003011 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 526227003012 homotrimer interaction site [polypeptide binding]; other site 526227003013 zinc binding site [ion binding]; other site 526227003014 CDP-binding sites; other site 526227003015 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 526227003016 FUN14 family; Region: FUN14; pfam04930 526227003017 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 526227003018 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 526227003019 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 526227003020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526227003021 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227003022 active site 526227003023 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 526227003024 oligomer interface [polypeptide binding]; other site 526227003025 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 526227003026 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 526227003027 dimer interface [polypeptide binding]; other site 526227003028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227003029 catalytic residue [active] 526227003030 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 526227003031 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 526227003032 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 526227003033 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227003034 metal ion-dependent adhesion site (MIDAS); other site 526227003035 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 526227003036 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 526227003037 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 526227003038 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 526227003039 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526227003040 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 526227003041 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 526227003042 Cysteine-rich domain; Region: CCG; pfam02754 526227003043 Cysteine-rich domain; Region: CCG; pfam02754 526227003044 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 526227003045 Putative esterase; Region: Esterase; pfam00756 526227003046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227003047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227003048 phosphorylation site [posttranslational modification] 526227003049 dimer interface [polypeptide binding]; other site 526227003050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227003051 ATP binding site [chemical binding]; other site 526227003052 Mg2+ binding site [ion binding]; other site 526227003053 G-X-G motif; other site 526227003054 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227003055 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227003056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227003057 active site 526227003058 phosphorylation site [posttranslational modification] 526227003059 intermolecular recognition site; other site 526227003060 dimerization interface [polypeptide binding]; other site 526227003061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227003062 DNA binding site [nucleotide binding] 526227003063 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526227003064 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 526227003065 putative substrate binding site [chemical binding]; other site 526227003066 putative ATP binding site [chemical binding]; other site 526227003067 Class I aldolases; Region: Aldolase_Class_I; cl17187 526227003068 catalytic residue [active] 526227003069 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 526227003070 generic binding surface I; other site 526227003071 generic binding surface II; other site 526227003072 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 526227003073 putative active site [active] 526227003074 putative catalytic site [active] 526227003075 putative Mg binding site IVb [ion binding]; other site 526227003076 putative phosphate binding site [ion binding]; other site 526227003077 putative DNA binding site [nucleotide binding]; other site 526227003078 putative Mg binding site IVa [ion binding]; other site 526227003079 MMPL family; Region: MMPL; pfam03176 526227003080 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 526227003081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227003082 NAD(P) binding site [chemical binding]; other site 526227003083 active site 526227003084 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 526227003085 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526227003086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 526227003087 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 526227003088 active site 526227003089 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 526227003090 putative active site [active] 526227003091 TPR repeat; Region: TPR_11; pfam13414 526227003092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227003093 binding surface 526227003094 TPR motif; other site 526227003095 Transposase [DNA replication, recombination, and repair]; Region: COG5421 526227003096 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 526227003097 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 526227003098 Low molecular weight phosphatase family; Region: LMWPc; cd00115 526227003099 active site 526227003100 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 526227003101 Low molecular weight phosphatase family; Region: LMWPc; cd00115 526227003102 active site 526227003103 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 526227003104 oligoendopeptidase F; Region: pepF; TIGR00181 526227003105 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 526227003106 active site 526227003107 Zn binding site [ion binding]; other site 526227003108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227003109 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 526227003110 Probable transposase; Region: OrfB_IS605; pfam01385 526227003111 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227003112 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 526227003113 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 526227003114 active site 526227003115 catalytic triad [active] 526227003116 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 526227003117 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 526227003118 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 526227003119 cobalamin binding residues [chemical binding]; other site 526227003120 putative BtuC binding residues; other site 526227003121 dimer interface [polypeptide binding]; other site 526227003122 FOG: WD40 repeat [General function prediction only]; Region: COG2319 526227003123 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 526227003124 structural tetrad; other site 526227003125 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 526227003126 structural tetrad; other site 526227003127 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 526227003128 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 526227003129 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 526227003130 BioY family; Region: BioY; pfam02632 526227003131 Isochorismatase family; Region: Isochorismatase; pfam00857 526227003132 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 526227003133 catalytic triad [active] 526227003134 conserved cis-peptide bond; other site 526227003135 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 526227003136 endonuclease III; Region: ENDO3c; smart00478 526227003137 minor groove reading motif; other site 526227003138 helix-hairpin-helix signature motif; other site 526227003139 substrate binding pocket [chemical binding]; other site 526227003140 active site 526227003141 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 526227003142 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 526227003143 histidinol-phosphatase; Provisional; Region: PRK07328 526227003144 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 526227003145 active site 526227003146 dimer interface [polypeptide binding]; other site 526227003147 hypothetical protein; Provisional; Region: PRK08609 526227003148 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 526227003149 metal binding triad [ion binding]; metal-binding site 526227003150 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 526227003151 active site 526227003152 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 526227003153 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 526227003154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227003155 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 526227003156 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 526227003157 four helix bundle protein; Region: TIGR02436 526227003158 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 526227003159 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526227003160 E3 interaction surface; other site 526227003161 lipoyl attachment site [posttranslational modification]; other site 526227003162 e3 binding domain; Region: E3_binding; pfam02817 526227003163 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 526227003164 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 526227003165 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 526227003166 alpha subunit interface [polypeptide binding]; other site 526227003167 TPP binding site [chemical binding]; other site 526227003168 heterodimer interface [polypeptide binding]; other site 526227003169 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526227003170 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 526227003171 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 526227003172 tetramer interface [polypeptide binding]; other site 526227003173 TPP-binding site [chemical binding]; other site 526227003174 heterodimer interface [polypeptide binding]; other site 526227003175 phosphorylation loop region [posttranslational modification] 526227003176 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 526227003177 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 526227003178 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 526227003179 putative metal binding site [ion binding]; other site 526227003180 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526227003181 active site 526227003182 metal binding site [ion binding]; metal-binding site 526227003183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227003184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227003185 putative substrate translocation pore; other site 526227003186 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 526227003187 Alkylmercury lyase; Region: MerB; pfam03243 526227003188 Transposase [DNA replication, recombination, and repair]; Region: COG5421 526227003189 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 526227003190 mercuric reductase; Region: MerA; TIGR02053 526227003191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526227003192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227003193 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 526227003194 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526227003195 metal-binding site [ion binding] 526227003196 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 526227003197 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 526227003198 DNA binding residues [nucleotide binding] 526227003199 dimer interface [polypeptide binding]; other site 526227003200 metal binding site [ion binding]; metal-binding site 526227003201 putative transposase OrfB; Reviewed; Region: PHA02517 526227003202 Integrase core domain; Region: rve; pfam00665 526227003203 Integrase core domain; Region: rve_3; pfam13683 526227003204 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 526227003205 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 526227003206 ligand binding site [chemical binding]; other site 526227003207 homodimer interface [polypeptide binding]; other site 526227003208 NAD(P) binding site [chemical binding]; other site 526227003209 trimer interface B [polypeptide binding]; other site 526227003210 trimer interface A [polypeptide binding]; other site 526227003211 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 526227003212 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 526227003213 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 526227003214 putative transposase OrfB; Reviewed; Region: PHA02517 526227003215 Integrase core domain; Region: rve; pfam00665 526227003216 Integrase core domain; Region: rve_3; pfam13683 526227003217 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 526227003218 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 526227003219 active site 526227003220 Zn binding site [ion binding]; other site 526227003221 C-terminal peptidase (prc); Region: prc; TIGR00225 526227003222 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526227003223 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 526227003224 Domain interface; other site 526227003225 Peptide binding site; other site 526227003226 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 526227003227 homodimer interface [polypeptide binding]; other site 526227003228 metal binding site [ion binding]; metal-binding site 526227003229 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 526227003230 active site 526227003231 dimer interfaces [polypeptide binding]; other site 526227003232 catalytic residues [active] 526227003233 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 526227003234 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 526227003235 MutS domain III; Region: MutS_III; pfam05192 526227003236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227003237 Walker A/P-loop; other site 526227003238 ATP binding site [chemical binding]; other site 526227003239 Q-loop/lid; other site 526227003240 ABC transporter signature motif; other site 526227003241 Walker B; other site 526227003242 D-loop; other site 526227003243 H-loop/switch region; other site 526227003244 Smr domain; Region: Smr; pfam01713 526227003245 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 526227003246 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 526227003247 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 526227003248 active site 526227003249 homodimer interface [polypeptide binding]; other site 526227003250 catalytic site [active] 526227003251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227003252 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227003253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227003254 dimer interface [polypeptide binding]; other site 526227003255 conserved gate region; other site 526227003256 putative PBP binding loops; other site 526227003257 ABC-ATPase subunit interface; other site 526227003258 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 526227003259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227003260 putative PBP binding loops; other site 526227003261 ABC-ATPase subunit interface; other site 526227003262 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 526227003263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227003264 short chain dehydrogenase; Provisional; Region: PRK07326 526227003265 classical (c) SDR, subgroup 4; Region: SDR_c4; cd08929 526227003266 putative NAD(P) binding site [chemical binding]; other site 526227003267 homodimer interface [polypeptide binding]; other site 526227003268 active site 526227003269 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003270 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003271 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 526227003272 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 526227003273 active site 526227003274 dimerization interface [polypeptide binding]; other site 526227003275 ribonuclease PH; Reviewed; Region: rph; PRK00173 526227003276 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 526227003277 oligomer interface [polypeptide binding]; other site 526227003278 RNA binding site [nucleotide binding]; other site 526227003279 putative transposase OrfB; Reviewed; Region: PHA02517 526227003280 Integrase core domain; Region: rve; pfam00665 526227003281 Integrase core domain; Region: rve_3; pfam13683 526227003282 integrase; Provisional; Region: int; PHA02601 526227003283 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 526227003284 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 526227003285 Int/Topo IB signature motif; other site 526227003286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227003287 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 526227003288 Probable transposase; Region: OrfB_IS605; pfam01385 526227003289 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227003290 Domain found in IF2B/IF5; Region: eIF-5_eIF-2B; cl17014 526227003291 Transposase IS200 like; Region: Y1_Tnp; pfam01797 526227003292 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 526227003293 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 526227003294 Catalytic site [active] 526227003295 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526227003296 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227003297 non-specific DNA binding site [nucleotide binding]; other site 526227003298 salt bridge; other site 526227003299 sequence-specific DNA binding site [nucleotide binding]; other site 526227003300 Helix-turn-helix domain; Region: HTH_17; pfam12728 526227003301 AAA domain; Region: AAA_30; pfam13604 526227003302 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 526227003303 Family description; Region: UvrD_C_2; pfam13538 526227003304 VRR-NUC domain; Region: VRR_NUC; pfam08774 526227003305 Domain of unknown function (DUF927); Region: DUF927; cl12098 526227003306 Phage terminase large subunit; Region: Terminase_3; cl12054 526227003307 Phage-related protein [Function unknown]; Region: COG4695; cl01923 526227003308 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 526227003309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227003310 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 526227003311 Probable transposase; Region: OrfB_IS605; pfam01385 526227003312 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227003313 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 526227003314 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 526227003315 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 526227003316 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 526227003317 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526227003318 active site 526227003319 metal binding site [ion binding]; metal-binding site 526227003320 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003321 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003322 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 526227003323 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227003324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 526227003325 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 526227003326 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 526227003327 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 526227003328 CT1975-like protein; Region: Cas_CT1975; pfam09344 526227003329 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 526227003330 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 526227003331 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 526227003332 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 526227003333 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 526227003334 putative transposase OrfB; Reviewed; Region: PHA02517 526227003335 Integrase core domain; Region: rve; pfam00665 526227003336 Integrase core domain; Region: rve_3; pfam13683 526227003337 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 526227003338 active site 526227003339 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526227003340 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227003341 polyphosphate kinase; Provisional; Region: PRK05443 526227003342 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 526227003343 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 526227003344 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 526227003345 putative active site [active] 526227003346 catalytic site [active] 526227003347 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 526227003348 putative active site [active] 526227003349 catalytic site [active] 526227003350 exopolyphosphatase; Region: exo_poly_only; TIGR03706 526227003351 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 526227003352 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 526227003353 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526227003354 catalytic core [active] 526227003355 CHAD domain; Region: CHAD; pfam05235 526227003356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227003357 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 526227003358 dimer interface [polypeptide binding]; other site 526227003359 putative metal binding site [ion binding]; other site 526227003360 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 526227003361 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227003362 substrate binding site [chemical binding]; other site 526227003363 oxyanion hole (OAH) forming residues; other site 526227003364 trimer interface [polypeptide binding]; other site 526227003365 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 526227003366 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 526227003367 Sulfatase; Region: Sulfatase; pfam00884 526227003368 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 526227003369 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 526227003370 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 526227003371 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227003372 MULE transposase domain; Region: MULE; pfam10551 526227003373 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 526227003374 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 526227003375 23S rRNA binding site [nucleotide binding]; other site 526227003376 L21 binding site [polypeptide binding]; other site 526227003377 L13 binding site [polypeptide binding]; other site 526227003378 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 526227003379 Predicted dehydrogenase [General function prediction only]; Region: COG5322 526227003380 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 526227003381 NAD(P) binding pocket [chemical binding]; other site 526227003382 futalosine nucleosidase; Region: fut_nucase; TIGR03664 526227003383 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 526227003384 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 526227003385 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 526227003386 Protein of unknown function (DUF502); Region: DUF502; cl01107 526227003387 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227003388 MULE transposase domain; Region: MULE; pfam10551 526227003389 Protein of unknown function (DUF456); Region: DUF456; pfam04306 526227003390 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 526227003391 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 526227003392 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 526227003393 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 526227003394 Substrate binding site; other site 526227003395 Mg++ binding site; other site 526227003396 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 526227003397 active site 526227003398 substrate binding site [chemical binding]; other site 526227003399 CoA binding site [chemical binding]; other site 526227003400 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 526227003401 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 526227003402 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 526227003403 Chorismate mutase type II; Region: CM_2; cl00693 526227003404 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 526227003405 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 526227003406 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526227003407 NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008 526227003408 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526227003409 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 526227003410 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526227003411 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 526227003412 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 526227003413 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 526227003414 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 526227003415 4Fe-4S binding domain; Region: Fer4; pfam00037 526227003416 4Fe-4S binding domain; Region: Fer4; pfam00037 526227003417 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 526227003418 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 526227003419 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 526227003420 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526227003421 catalytic loop [active] 526227003422 iron binding site [ion binding]; other site 526227003423 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 526227003424 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526227003425 molybdopterin cofactor binding site; other site 526227003426 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 526227003427 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 526227003428 SLBB domain; Region: SLBB; pfam10531 526227003429 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 526227003430 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 526227003431 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 526227003432 putative dimer interface [polypeptide binding]; other site 526227003433 [2Fe-2S] cluster binding site [ion binding]; other site 526227003434 NADH dehydrogenase subunit D; Validated; Region: PRK06075 526227003435 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 526227003436 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 526227003437 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 526227003438 NADH dehydrogenase subunit B; Validated; Region: PRK06411 526227003439 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 526227003440 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526227003441 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 526227003442 acyl-activating enzyme (AAE) consensus motif; other site 526227003443 active site 526227003444 AMP binding site [chemical binding]; other site 526227003445 CoA binding site [chemical binding]; other site 526227003446 HipA N-terminal domain; Region: Couple_hipA; cl11853 526227003447 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 526227003448 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526227003449 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 526227003450 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 526227003451 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 526227003452 homodimer interface [polypeptide binding]; other site 526227003453 substrate-cofactor binding pocket; other site 526227003454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227003455 catalytic residue [active] 526227003456 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 526227003457 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 526227003458 ATP-grasp domain; Region: ATP-grasp; pfam02222 526227003459 Domain of unknown function (DUF897); Region: DUF897; cl01312 526227003460 Nitrogen regulatory protein P-II; Region: P-II; smart00938 526227003461 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 526227003462 isocitrate dehydrogenase; Validated; Region: PRK09222 526227003463 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 526227003464 Integral membrane protein TerC family; Region: TerC; cl10468 526227003465 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 526227003466 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 526227003467 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 526227003468 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 526227003469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 526227003470 glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703 526227003471 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526227003472 active site 526227003473 HIGH motif; other site 526227003474 nucleotide binding site [chemical binding]; other site 526227003475 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 526227003476 KMSKS motif; other site 526227003477 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 526227003478 GatB domain; Region: GatB_Yqey; smart00845 526227003479 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 526227003480 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 526227003481 active site 526227003482 catalytic site [active] 526227003483 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227003484 MULE transposase domain; Region: MULE; pfam10551 526227003485 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 526227003486 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 526227003487 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526227003488 UDP-galactopyranose mutase; Region: GLF; pfam03275 526227003489 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 526227003490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227003491 putative homodimer interface [polypeptide binding]; other site 526227003492 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 526227003493 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227003494 ligand binding site [chemical binding]; other site 526227003495 flexible hinge region; other site 526227003496 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 526227003497 non-specific DNA interactions [nucleotide binding]; other site 526227003498 DNA binding site [nucleotide binding] 526227003499 sequence specific DNA binding site [nucleotide binding]; other site 526227003500 putative cAMP binding site [chemical binding]; other site 526227003501 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 526227003502 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 526227003503 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 526227003504 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 526227003505 putative hydrophobic ligand binding site [chemical binding]; other site 526227003506 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 526227003507 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 526227003508 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 526227003509 PHP domain; Region: PHP; pfam02811 526227003510 active site 526227003511 PHP-associated; Region: PHP_C; pfam13263 526227003512 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 526227003513 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 526227003514 Domain of unknown function DUF20; Region: UPF0118; pfam01594 526227003515 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 526227003516 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 526227003517 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 526227003518 effector binding site; other site 526227003519 dimer interface [polypeptide binding]; other site 526227003520 active site 526227003521 TSCPD domain; Region: TSCPD; pfam12637 526227003522 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 526227003523 active site 526227003524 homodimer interface [polypeptide binding]; other site 526227003525 catalytic site [active] 526227003526 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 526227003527 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 526227003528 catalytic site [active] 526227003529 G-X2-G-X-G-K; other site 526227003530 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 526227003531 Arginine repressor [Transcription]; Region: ArgR; COG1438 526227003532 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 526227003533 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 526227003534 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 526227003535 PAS domain; Region: PAS_9; pfam13426 526227003536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526227003537 putative active site [active] 526227003538 heme pocket [chemical binding]; other site 526227003539 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526227003540 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526227003541 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227003542 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227003543 metal binding site [ion binding]; metal-binding site 526227003544 active site 526227003545 I-site; other site 526227003546 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 526227003547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227003548 Walker A/P-loop; other site 526227003549 ATP binding site [chemical binding]; other site 526227003550 Q-loop/lid; other site 526227003551 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 526227003552 ABC transporter signature motif; other site 526227003553 Walker B; other site 526227003554 D-loop; other site 526227003555 H-loop/switch region; other site 526227003556 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 526227003557 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 526227003558 active site residue [active] 526227003559 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 526227003560 active site residue [active] 526227003561 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14662 526227003562 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 526227003563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227003564 S-adenosylmethionine binding site [chemical binding]; other site 526227003565 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 526227003566 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 526227003567 active site 526227003568 dimer interface [polypeptide binding]; other site 526227003569 metal binding site [ion binding]; metal-binding site 526227003570 shikimate kinase; Provisional; Region: PRK13948 526227003571 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 526227003572 ADP binding site [chemical binding]; other site 526227003573 magnesium binding site [ion binding]; other site 526227003574 putative shikimate binding site; other site 526227003575 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 526227003576 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 526227003577 Tetramer interface [polypeptide binding]; other site 526227003578 active site 526227003579 FMN-binding site [chemical binding]; other site 526227003580 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 526227003581 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 526227003582 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 526227003583 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 526227003584 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 526227003585 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 526227003586 Cell division protein FtsA; Region: FtsA; pfam14450 526227003587 tartrate dehydrogenase; Region: TTC; TIGR02089 526227003588 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 526227003589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227003590 Zn2+ binding site [ion binding]; other site 526227003591 Mg2+ binding site [ion binding]; other site 526227003592 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526227003593 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 526227003594 Probable Catalytic site; other site 526227003595 metal-binding site 526227003596 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 526227003597 Helix-turn-helix domain; Region: HTH_17; cl17695 526227003598 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 526227003599 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 526227003600 polymerase nucleotide-binding site; other site 526227003601 DNA-binding residues [nucleotide binding]; DNA binding site 526227003602 nucleotide binding site [chemical binding]; other site 526227003603 primase nucleotide-binding site [nucleotide binding]; other site 526227003604 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003605 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003606 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 526227003607 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 526227003608 active site 526227003609 catalytic site [active] 526227003610 substrate binding site [chemical binding]; other site 526227003611 Phylum Aquificae Pol A is different from Escherichia coli Pol A by three signature sequences; Region: DNA_pol_A_Aquificae_like; cd08639 526227003612 active site 526227003613 DNA binding site [nucleotide binding] 526227003614 catalytic site [active] 526227003615 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 526227003616 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526227003617 active site 526227003618 DNA binding site [nucleotide binding] 526227003619 Int/Topo IB signature motif; other site 526227003620 putative transposase OrfB; Reviewed; Region: PHA02517 526227003621 Integrase core domain; Region: rve; pfam00665 526227003622 Integrase core domain; Region: rve_3; pfam13683 526227003623 2-phosphoglycerate kinase; Provisional; Region: PRK12337 526227003624 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 526227003625 Active site serine [active] 526227003626 Predicted amidohydrolase [General function prediction only]; Region: COG0388 526227003627 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 526227003628 active site 526227003629 catalytic triad [active] 526227003630 dimer interface [polypeptide binding]; other site 526227003631 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 526227003632 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 526227003633 Catalytic site [active] 526227003634 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 526227003635 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 526227003636 threonine synthase; Validated; Region: PRK09225 526227003637 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227003638 catalytic residue [active] 526227003639 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 526227003640 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 526227003641 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 526227003642 epoxyqueuosine reductase; Region: TIGR00276 526227003643 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 526227003644 4Fe-4S binding domain; Region: Fer4; cl02805 526227003645 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 526227003646 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 526227003647 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 526227003648 putative active site [active] 526227003649 catalytic triad [active] 526227003650 putative dimer interface [polypeptide binding]; other site 526227003651 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 526227003652 putative transposase OrfB; Reviewed; Region: PHA02517 526227003653 Integrase core domain; Region: rve; pfam00665 526227003654 Integrase core domain; Region: rve_3; pfam13683 526227003655 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 526227003656 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 526227003657 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227003658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227003659 dimer interface [polypeptide binding]; other site 526227003660 conserved gate region; other site 526227003661 ABC-ATPase subunit interface; other site 526227003662 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526227003663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227003664 dimer interface [polypeptide binding]; other site 526227003665 conserved gate region; other site 526227003666 putative PBP binding loops; other site 526227003667 ABC-ATPase subunit interface; other site 526227003668 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 526227003669 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 526227003670 Walker A/P-loop; other site 526227003671 ATP binding site [chemical binding]; other site 526227003672 Q-loop/lid; other site 526227003673 ABC transporter signature motif; other site 526227003674 Walker B; other site 526227003675 D-loop; other site 526227003676 H-loop/switch region; other site 526227003677 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 526227003678 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 526227003679 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 526227003680 Walker A/P-loop; other site 526227003681 ATP binding site [chemical binding]; other site 526227003682 Q-loop/lid; other site 526227003683 ABC transporter signature motif; other site 526227003684 Walker B; other site 526227003685 D-loop; other site 526227003686 H-loop/switch region; other site 526227003687 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 526227003688 Uncharacterized conserved protein [Function unknown]; Region: COG5316 526227003689 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 526227003690 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 526227003691 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526227003692 EamA-like transporter family; Region: EamA; pfam00892 526227003693 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 526227003694 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 526227003695 recombination protein RecR; Reviewed; Region: recR; PRK00076 526227003696 RecR protein; Region: RecR; pfam02132 526227003697 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 526227003698 putative active site [active] 526227003699 putative metal-binding site [ion binding]; other site 526227003700 tetramer interface [polypeptide binding]; other site 526227003701 hypothetical protein; Validated; Region: PRK00153 526227003702 H+ Antiporter protein; Region: 2A0121; TIGR00900 526227003703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227003704 putative substrate translocation pore; other site 526227003705 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 526227003706 Protein phosphatase 2C; Region: PP2C; pfam00481 526227003707 active site 526227003708 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526227003709 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526227003710 active site 526227003711 ATP binding site [chemical binding]; other site 526227003712 substrate binding site [chemical binding]; other site 526227003713 activation loop (A-loop); other site 526227003714 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 526227003715 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 526227003716 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 526227003717 catalytic triad [active] 526227003718 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 526227003719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526227003720 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 526227003721 DNA photolyase; Region: DNA_photolyase; pfam00875 526227003722 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 526227003723 Fasciclin domain; Region: Fasciclin; pfam02469 526227003724 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003725 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003726 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 526227003727 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 526227003728 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526227003729 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227003730 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 526227003731 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 526227003732 Walker A/P-loop; other site 526227003733 ATP binding site [chemical binding]; other site 526227003734 Q-loop/lid; other site 526227003735 ABC transporter signature motif; other site 526227003736 Walker B; other site 526227003737 D-loop; other site 526227003738 H-loop/switch region; other site 526227003739 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 526227003740 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526227003741 ABC-ATPase subunit interface; other site 526227003742 dimer interface [polypeptide binding]; other site 526227003743 putative PBP binding regions; other site 526227003744 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 526227003745 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526227003746 intersubunit interface [polypeptide binding]; other site 526227003747 putative transposase OrfB; Reviewed; Region: PHA02517 526227003748 Integrase core domain; Region: rve; pfam00665 526227003749 Integrase core domain; Region: rve_3; pfam13683 526227003750 YceI-like domain; Region: YceI; pfam04264 526227003751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227003752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526227003753 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227003754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227003755 active site 526227003756 phosphorylation site [posttranslational modification] 526227003757 intermolecular recognition site; other site 526227003758 dimerization interface [polypeptide binding]; other site 526227003759 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227003760 DNA binding site [nucleotide binding] 526227003761 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227003762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227003763 dimer interface [polypeptide binding]; other site 526227003764 phosphorylation site [posttranslational modification] 526227003765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227003766 ATP binding site [chemical binding]; other site 526227003767 Mg2+ binding site [ion binding]; other site 526227003768 G-X-G motif; other site 526227003769 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 526227003770 Cu(I) binding site [ion binding]; other site 526227003771 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 526227003772 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 526227003773 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 526227003774 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 526227003775 Part of AAA domain; Region: AAA_19; pfam13245 526227003776 Family description; Region: UvrD_C_2; pfam13538 526227003777 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 526227003778 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 526227003779 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 526227003780 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 526227003781 inhibitor-cofactor binding pocket; inhibition site 526227003782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227003783 catalytic residue [active] 526227003784 Predicted permeases [General function prediction only]; Region: COG0795 526227003785 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 526227003786 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 526227003787 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526227003788 active site 526227003789 metal binding site [ion binding]; metal-binding site 526227003790 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 526227003791 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 526227003792 putative RNA binding site [nucleotide binding]; other site 526227003793 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 526227003794 glycogen binding site [chemical binding]; other site 526227003795 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 526227003796 carbohydrate binding site [chemical binding]; other site 526227003797 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 526227003798 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 526227003799 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 526227003800 Ca binding site [ion binding]; other site 526227003801 active site 526227003802 catalytic site [active] 526227003803 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 526227003804 maltodextrin glucosidase; Provisional; Region: PRK10785 526227003805 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 526227003806 active site 526227003807 homodimer interface [polypeptide binding]; other site 526227003808 catalytic site [active] 526227003809 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 526227003810 AzlC protein; Region: AzlC; cl00570 526227003811 Predicted membrane protein [Function unknown]; Region: COG4392 526227003812 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 526227003813 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 526227003814 active site 526227003815 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 526227003816 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526227003817 Walker A/P-loop; other site 526227003818 ATP binding site [chemical binding]; other site 526227003819 Q-loop/lid; other site 526227003820 ABC transporter signature motif; other site 526227003821 Walker B; other site 526227003822 D-loop; other site 526227003823 H-loop/switch region; other site 526227003824 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 526227003825 C-terminal peptidase (prc); Region: prc; TIGR00225 526227003826 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 526227003827 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 526227003828 Catalytic dyad [active] 526227003829 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 526227003830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227003831 Walker A/P-loop; other site 526227003832 ATP binding site [chemical binding]; other site 526227003833 Q-loop/lid; other site 526227003834 ABC transporter signature motif; other site 526227003835 Walker B; other site 526227003836 D-loop; other site 526227003837 H-loop/switch region; other site 526227003838 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 526227003839 30S subunit binding site; other site 526227003840 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 526227003841 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227003842 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 526227003843 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 526227003844 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 526227003845 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 526227003846 MOFRL family; Region: MOFRL; pfam05161 526227003847 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 526227003848 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 526227003849 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 526227003850 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526227003851 Cysteine-rich domain; Region: CCG; pfam02754 526227003852 Cysteine-rich domain; Region: CCG; pfam02754 526227003853 FAD binding domain; Region: FAD_binding_4; pfam01565 526227003854 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 526227003855 FAD binding domain; Region: FAD_binding_4; pfam01565 526227003856 Protein of unknown function DUF58; Region: DUF58; pfam01882 526227003857 MoxR-like ATPases [General function prediction only]; Region: COG0714 526227003858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227003859 Walker A motif; other site 526227003860 ATP binding site [chemical binding]; other site 526227003861 Walker B motif; other site 526227003862 arginine finger; other site 526227003863 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 526227003864 malate synthase A; Region: malate_syn_A; TIGR01344 526227003865 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 526227003866 active site 526227003867 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 526227003868 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 526227003869 putative Iron-sulfur protein interface [polypeptide binding]; other site 526227003870 putative proximal heme binding site [chemical binding]; other site 526227003871 putative SdhD-like interface [polypeptide binding]; other site 526227003872 putative distal heme binding site [chemical binding]; other site 526227003873 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 526227003874 Iron-sulfur protein interface; other site 526227003875 proximal heme binding site [chemical binding]; other site 526227003876 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 526227003877 L-aspartate oxidase; Provisional; Region: PRK06175 526227003878 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 526227003879 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 526227003880 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 526227003881 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526227003882 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 526227003883 Dynamin family; Region: Dynamin_N; pfam00350 526227003884 G1 box; other site 526227003885 GTP/Mg2+ binding site [chemical binding]; other site 526227003886 G2 box; other site 526227003887 Switch I region; other site 526227003888 G3 box; other site 526227003889 Switch II region; other site 526227003890 G4 box; other site 526227003891 G5 box; other site 526227003892 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 526227003893 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 526227003894 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 526227003895 acyl-activating enzyme (AAE) consensus motif; other site 526227003896 putative AMP binding site [chemical binding]; other site 526227003897 putative active site [active] 526227003898 putative CoA binding site [chemical binding]; other site 526227003899 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526227003900 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526227003901 active site 526227003902 ATP binding site [chemical binding]; other site 526227003903 substrate binding site [chemical binding]; other site 526227003904 activation loop (A-loop); other site 526227003905 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 526227003906 metal-dependent hydrolase; Provisional; Region: PRK00685 526227003907 Protein of unknown function (DUF3809); Region: DUF3809; pfam12723 526227003908 Protein of unknown function (DUF3248); Region: DUF3248; pfam11609 526227003909 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 526227003910 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 526227003911 putative RNA binding site [nucleotide binding]; other site 526227003912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227003913 S-adenosylmethionine binding site [chemical binding]; other site 526227003914 V-type ATP synthase subunit I; Validated; Region: PRK05771 526227003915 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 526227003916 Flagellar assembly protein FliH; Region: FliH; pfam02108 526227003917 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 526227003918 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 526227003919 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 526227003920 V-type ATP synthase subunit A; Provisional; Region: PRK04192 526227003921 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 526227003922 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 526227003923 Walker A motif/ATP binding site; other site 526227003924 Walker B motif; other site 526227003925 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 526227003926 V-type ATP synthase subunit B; Provisional; Region: PRK04196 526227003927 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 526227003928 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 526227003929 Walker A motif homologous position; other site 526227003930 Walker B motif; other site 526227003931 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 526227003932 Archaeal/vacuolar-type H+-ATPase subunit D [Energy production and conversion]; Region: NtpD; COG1394 526227003933 Pectinacetylesterase; Region: PAE; pfam03283 526227003934 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 526227003935 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 526227003936 generic binding surface II; other site 526227003937 ssDNA binding site; other site 526227003938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227003939 ATP binding site [chemical binding]; other site 526227003940 putative Mg++ binding site [ion binding]; other site 526227003941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227003942 nucleotide binding region [chemical binding]; other site 526227003943 ATP-binding site [chemical binding]; other site 526227003944 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 526227003945 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 526227003946 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 526227003947 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 526227003948 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 526227003949 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 526227003950 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 526227003951 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 526227003952 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227003953 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227003954 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 526227003955 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 526227003956 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526227003957 4-alpha-glucanotransferase; Provisional; Region: PRK14508 526227003958 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227003959 MULE transposase domain; Region: MULE; pfam10551 526227003960 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227003961 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526227003962 active site 526227003963 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 526227003964 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 526227003965 Protein export membrane protein; Region: SecD_SecF; pfam02355 526227003966 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 526227003967 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 526227003968 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 526227003969 G1 box; other site 526227003970 putative GEF interaction site [polypeptide binding]; other site 526227003971 GTP/Mg2+ binding site [chemical binding]; other site 526227003972 Switch I region; other site 526227003973 G2 box; other site 526227003974 G3 box; other site 526227003975 Switch II region; other site 526227003976 G4 box; other site 526227003977 G5 box; other site 526227003978 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 526227003979 Translation-initiation factor 2; Region: IF-2; pfam11987 526227003980 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 526227003981 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 526227003982 putative RNA binding cleft [nucleotide binding]; other site 526227003983 transcription termination factor NusA; Region: NusA; TIGR01953 526227003984 NusA N-terminal domain; Region: NusA_N; pfam08529 526227003985 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 526227003986 RNA binding site [nucleotide binding]; other site 526227003987 homodimer interface [polypeptide binding]; other site 526227003988 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 526227003989 G-X-X-G motif; other site 526227003990 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 526227003991 G-X-X-G motif; other site 526227003992 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 526227003993 Sm and related proteins; Region: Sm_like; cl00259 526227003994 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 526227003995 putative RNA binding site [nucleotide binding]; other site 526227003996 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 526227003997 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 526227003998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526227003999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526227004000 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811 526227004001 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 526227004002 DNA binding site [nucleotide binding] 526227004003 catalytic residue [active] 526227004004 H2TH interface [polypeptide binding]; other site 526227004005 putative catalytic residues [active] 526227004006 turnover-facilitating residue; other site 526227004007 intercalation triad [nucleotide binding]; other site 526227004008 8OG recognition residue [nucleotide binding]; other site 526227004009 putative reading head residues; other site 526227004010 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 526227004011 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 526227004012 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 526227004013 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 526227004014 putative NAD(P) binding site [chemical binding]; other site 526227004015 active site 526227004016 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 526227004017 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227004018 ligand binding site [chemical binding]; other site 526227004019 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 526227004020 putative switch regulator; other site 526227004021 non-specific DNA interactions [nucleotide binding]; other site 526227004022 DNA binding site [nucleotide binding] 526227004023 sequence specific DNA binding site [nucleotide binding]; other site 526227004024 putative cAMP binding site [chemical binding]; other site 526227004025 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526227004026 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 526227004027 DNA binding residues [nucleotide binding] 526227004028 B12 binding domain; Region: B12-binding_2; pfam02607 526227004029 B12 binding domain; Region: B12-binding; pfam02310 526227004030 B12 binding site [chemical binding]; other site 526227004031 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 526227004032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227004033 S-adenosylmethionine binding site [chemical binding]; other site 526227004034 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 526227004035 active site lid residues [active] 526227004036 substrate binding pocket [chemical binding]; other site 526227004037 catalytic residues [active] 526227004038 substrate-Mg2+ binding site; other site 526227004039 aspartate-rich region 1; other site 526227004040 aspartate-rich region 2; other site 526227004041 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 526227004042 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526227004043 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 526227004044 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 526227004045 lycopene cyclase; Region: lycopene_cycl; TIGR01789 526227004046 Protein of unknown function (DUF422); Region: DUF422; pfam04240 526227004047 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 526227004048 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 526227004049 putative acyl-acceptor binding pocket; other site 526227004050 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 526227004051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526227004052 active site 526227004053 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 526227004054 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526227004055 Cytochrome P450; Region: p450; cl12078 526227004056 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 526227004057 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 526227004058 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 526227004059 homotetramer interface [polypeptide binding]; other site 526227004060 FMN binding site [chemical binding]; other site 526227004061 homodimer contacts [polypeptide binding]; other site 526227004062 putative active site [active] 526227004063 putative substrate binding site [chemical binding]; other site 526227004064 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227004065 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227004066 putative transposase OrfB; Reviewed; Region: PHA02517 526227004067 Integrase core domain; Region: rve; pfam00665 526227004068 Integrase core domain; Region: rve_3; pfam13683 526227004069 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227004070 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227004071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227004072 TPR motif; other site 526227004073 binding surface 526227004074 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 526227004075 TPR repeat; Region: TPR_11; pfam13414 526227004076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227004077 binding surface 526227004078 TPR motif; other site 526227004079 TPR repeat; Region: TPR_11; pfam13414 526227004080 Sporulation related domain; Region: SPOR; pfam05036 526227004081 Sporulation related domain; Region: SPOR; pfam05036 526227004082 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 526227004083 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 526227004084 CoA binding domain; Region: CoA_binding; smart00881 526227004085 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 526227004086 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 526227004087 substrate binding pocket [chemical binding]; other site 526227004088 chain length determination region; other site 526227004089 substrate-Mg2+ binding site; other site 526227004090 catalytic residues [active] 526227004091 aspartate-rich region 1; other site 526227004092 active site lid residues [active] 526227004093 aspartate-rich region 2; other site 526227004094 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 526227004095 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 526227004096 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 526227004097 NAD(P) binding site [chemical binding]; other site 526227004098 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 526227004099 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 526227004100 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 526227004101 NAD(P) binding site [chemical binding]; other site 526227004102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526227004103 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526227004104 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 526227004105 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 526227004106 putative ligand binding site [chemical binding]; other site 526227004107 putative NAD binding site [chemical binding]; other site 526227004108 catalytic site [active] 526227004109 Methyltransferase domain; Region: Methyltransf_31; pfam13847 526227004110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227004111 S-adenosylmethionine binding site [chemical binding]; other site 526227004112 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 526227004113 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 526227004114 GIY-YIG motif/motif A; other site 526227004115 active site 526227004116 catalytic site [active] 526227004117 putative DNA binding site [nucleotide binding]; other site 526227004118 metal binding site [ion binding]; metal-binding site 526227004119 UvrB/uvrC motif; Region: UVR; pfam02151 526227004120 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 526227004121 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 526227004122 NADH-quinone oxidoreductase chain 15; Region: NADH_Oxid_Nqo15; pfam11497 526227004123 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 526227004124 substrate binding site [chemical binding]; other site 526227004125 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 526227004126 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 526227004127 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 526227004128 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 526227004129 P loop; other site 526227004130 GTP binding site [chemical binding]; other site 526227004131 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 526227004132 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 526227004133 HIGH motif; other site 526227004134 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 526227004135 active site 526227004136 KMSKS motif; other site 526227004137 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 526227004138 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 526227004139 Walker A/P-loop; other site 526227004140 ATP binding site [chemical binding]; other site 526227004141 Q-loop/lid; other site 526227004142 ABC transporter signature motif; other site 526227004143 Walker B; other site 526227004144 D-loop; other site 526227004145 H-loop/switch region; other site 526227004146 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 526227004147 ornithine cyclodeaminase; Validated; Region: PRK07340 526227004148 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 526227004149 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 526227004150 MutS domain I; Region: MutS_I; pfam01624 526227004151 MutS domain II; Region: MutS_II; pfam05188 526227004152 MutS domain III; Region: MutS_III; pfam05192 526227004153 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 526227004154 Walker A/P-loop; other site 526227004155 ATP binding site [chemical binding]; other site 526227004156 Q-loop/lid; other site 526227004157 ABC transporter signature motif; other site 526227004158 Walker B; other site 526227004159 D-loop; other site 526227004160 H-loop/switch region; other site 526227004161 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 526227004162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227004163 ATP binding site [chemical binding]; other site 526227004164 Mg2+ binding site [ion binding]; other site 526227004165 G-X-G motif; other site 526227004166 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 526227004167 ATP binding site [chemical binding]; other site 526227004168 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 526227004169 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 526227004170 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 526227004171 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 526227004172 putative active site [active] 526227004173 putative substrate binding site [chemical binding]; other site 526227004174 putative cosubstrate binding site; other site 526227004175 catalytic site [active] 526227004176 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 526227004177 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526227004178 protein binding site [polypeptide binding]; other site 526227004179 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 526227004180 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 526227004181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227004182 FeS/SAM binding site; other site 526227004183 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227004184 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227004185 DNA binding site [nucleotide binding] 526227004186 domain linker motif; other site 526227004187 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227004188 membrane protein; Provisional; Region: PRK14401 526227004189 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 526227004190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227004191 Walker A/P-loop; other site 526227004192 ATP binding site [chemical binding]; other site 526227004193 Q-loop/lid; other site 526227004194 ABC transporter signature motif; other site 526227004195 Walker B; other site 526227004196 D-loop; other site 526227004197 H-loop/switch region; other site 526227004198 ABC transporter; Region: ABC_tran_2; pfam12848 526227004199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526227004200 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 526227004201 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 526227004202 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 526227004203 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526227004204 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 526227004205 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 526227004206 active site 526227004207 substrate binding site [chemical binding]; other site 526227004208 cosubstrate binding site; other site 526227004209 catalytic site [active] 526227004210 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 526227004211 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 526227004212 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 526227004213 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 526227004214 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 526227004215 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 526227004216 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 526227004217 active site 526227004218 dimerization interface [polypeptide binding]; other site 526227004219 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 526227004220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227004221 S-adenosylmethionine binding site [chemical binding]; other site 526227004222 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 526227004223 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 526227004224 G-X-X-G motif; other site 526227004225 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 526227004226 RxxxH motif; other site 526227004227 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 526227004228 Haemolytic domain; Region: Haemolytic; pfam01809 526227004229 Ribonuclease P; Region: Ribonuclease_P; pfam00825 526227004230 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 526227004231 putative transposase OrfB; Reviewed; Region: PHA02517 526227004232 Integrase core domain; Region: rve; pfam00665 526227004233 Integrase core domain; Region: rve_3; pfam13683 526227004234 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227004235 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 526227004236 Walker A/P-loop; other site 526227004237 ATP binding site [chemical binding]; other site 526227004238 Q-loop/lid; other site 526227004239 ABC transporter signature motif; other site 526227004240 Walker B; other site 526227004241 D-loop; other site 526227004242 H-loop/switch region; other site 526227004243 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 526227004244 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526227004245 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 526227004246 acyl-activating enzyme (AAE) consensus motif; other site 526227004247 putative AMP binding site [chemical binding]; other site 526227004248 putative active site [active] 526227004249 putative CoA binding site [chemical binding]; other site 526227004250 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227004251 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227004252 TM-ABC transporter signature motif; other site 526227004253 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 526227004254 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227004255 TM-ABC transporter signature motif; other site 526227004256 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227004257 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 526227004258 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227004259 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 526227004260 Walker A/P-loop; other site 526227004261 ATP binding site [chemical binding]; other site 526227004262 Q-loop/lid; other site 526227004263 ABC transporter signature motif; other site 526227004264 Walker B; other site 526227004265 D-loop; other site 526227004266 H-loop/switch region; other site 526227004267 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 526227004268 Predicted transcriptional regulators [Transcription]; Region: COG1733 526227004269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 526227004270 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 526227004271 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 526227004272 Switch I; other site 526227004273 Switch II; other site 526227004274 cell division topological specificity factor MinE; Region: minE; TIGR01215 526227004275 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 526227004276 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 526227004277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227004278 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227004279 Walker A/P-loop; other site 526227004280 ATP binding site [chemical binding]; other site 526227004281 Q-loop/lid; other site 526227004282 ABC transporter signature motif; other site 526227004283 Walker B; other site 526227004284 D-loop; other site 526227004285 H-loop/switch region; other site 526227004286 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 526227004287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227004288 dimer interface [polypeptide binding]; other site 526227004289 conserved gate region; other site 526227004290 putative PBP binding loops; other site 526227004291 ABC-ATPase subunit interface; other site 526227004292 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 526227004293 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526227004294 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526227004295 Moco binding site; other site 526227004296 TOBE domain; Region: TOBE; cl01440 526227004297 Predicted transcriptional regulators [Transcription]; Region: COG1695 526227004298 Transcriptional regulator PadR-like family; Region: PadR; cl17335 526227004299 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 526227004300 homodimer interaction site [polypeptide binding]; other site 526227004301 cofactor binding site; other site 526227004302 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 526227004303 Cytochrome c; Region: Cytochrom_C; pfam00034 526227004304 putative transposase OrfB; Reviewed; Region: PHA02517 526227004305 Integrase core domain; Region: rve; pfam00665 526227004306 Integrase core domain; Region: rve_3; pfam13683 526227004307 Cytochrome c; Region: Cytochrom_C; cl11414 526227004308 Cytochrome c; Region: Cytochrom_C; pfam00034 526227004309 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 526227004310 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526227004311 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526227004312 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 526227004313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227004314 ABC-ATPase subunit interface; other site 526227004315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227004316 dimer interface [polypeptide binding]; other site 526227004317 conserved gate region; other site 526227004318 putative PBP binding loops; other site 526227004319 ABC-ATPase subunit interface; other site 526227004320 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227004321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227004322 Walker A/P-loop; other site 526227004323 ATP binding site [chemical binding]; other site 526227004324 Q-loop/lid; other site 526227004325 ABC transporter signature motif; other site 526227004326 Walker B; other site 526227004327 D-loop; other site 526227004328 H-loop/switch region; other site 526227004329 TOBE domain; Region: TOBE_2; pfam08402 526227004330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227004331 metal ion-dependent adhesion site (MIDAS); other site 526227004332 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227004333 metal ion-dependent adhesion site (MIDAS); other site 526227004334 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227004335 active site 526227004336 catalytic residues [active] 526227004337 Transcriptional regulator [Transcription]; Region: LytR; COG1316 526227004338 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 526227004339 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 526227004340 Int/Topo IB signature motif; other site 526227004341 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 526227004342 polymerase nucleotide-binding site; other site 526227004343 DNA-binding residues [nucleotide binding]; DNA binding site 526227004344 nucleotide binding site [chemical binding]; other site 526227004345 primase nucleotide-binding site [nucleotide binding]; other site 526227004346 Domain of unknown function (DUF927); Region: DUF927; cl12098 526227004347 Helix-turn-helix domain; Region: HTH_17; pfam12728 526227004348 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 526227004349 active site 526227004350 catalytic site [active] 526227004351 substrate binding site [chemical binding]; other site 526227004352 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 526227004353 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227004354 ligand binding site [chemical binding]; other site 526227004355 flexible hinge region; other site 526227004356 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 526227004357 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 526227004358 metal binding triad; other site 526227004359 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227004360 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227004361 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526227004362 Bacterial transcriptional regulator; Region: IclR; pfam01614 526227004363 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526227004364 AMP-binding enzyme; Region: AMP-binding; pfam00501 526227004365 acyl-activating enzyme (AAE) consensus motif; other site 526227004366 active site 526227004367 AMP binding site [chemical binding]; other site 526227004368 CoA binding site [chemical binding]; other site 526227004369 acetyl-CoA synthetase; Provisional; Region: PRK00174 526227004370 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 526227004371 active site 526227004372 CoA binding site [chemical binding]; other site 526227004373 acyl-activating enzyme (AAE) consensus motif; other site 526227004374 AMP binding site [chemical binding]; other site 526227004375 acetate binding site [chemical binding]; other site 526227004376 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 526227004377 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 526227004378 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 526227004379 ABC 3 transport family; Region: ABC-3; pfam00950 526227004380 ABC-ATPase subunit interface; other site 526227004381 dimer interface [polypeptide binding]; other site 526227004382 putative PBP binding regions; other site 526227004383 Transcriptional regulator; Region: Rrf2; cl17282 526227004384 Rrf2 family protein; Region: rrf2_super; TIGR00738 526227004385 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 526227004386 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 526227004387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227004388 catalytic residue [active] 526227004389 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 526227004390 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 526227004391 acyl-activating enzyme (AAE) consensus motif; other site 526227004392 putative AMP binding site [chemical binding]; other site 526227004393 putative active site [active] 526227004394 putative CoA binding site [chemical binding]; other site 526227004395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227004396 active site 526227004397 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 526227004398 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 526227004399 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 526227004400 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 526227004401 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 526227004402 metal binding site [ion binding]; metal-binding site 526227004403 dimer interface [polypeptide binding]; other site 526227004404 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 526227004405 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 526227004406 classical (c) SDRs; Region: SDR_c; cd05233 526227004407 NAD(P) binding site [chemical binding]; other site 526227004408 active site 526227004409 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 526227004410 tartrate dehydrogenase; Region: TTC; TIGR02089 526227004411 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 526227004412 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 526227004413 substrate binding site [chemical binding]; other site 526227004414 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 526227004415 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 526227004416 substrate binding site [chemical binding]; other site 526227004417 ligand binding site [chemical binding]; other site 526227004418 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227004419 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 526227004420 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526227004421 protein binding site [polypeptide binding]; other site 526227004422 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 526227004423 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 526227004424 active site 526227004425 HIGH motif; other site 526227004426 dimer interface [polypeptide binding]; other site 526227004427 KMSKS motif; other site 526227004428 ScpA/B protein; Region: ScpA_ScpB; cl00598 526227004429 putative acyltransferase; Provisional; Region: PRK05790 526227004430 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526227004431 dimer interface [polypeptide binding]; other site 526227004432 active site 526227004433 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 526227004434 prephenate dehydrogenase; Validated; Region: PRK08507 526227004435 prephenate dehydrogenase; Validated; Region: PRK06545 526227004436 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 526227004437 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526227004438 CoenzymeA binding site [chemical binding]; other site 526227004439 subunit interaction site [polypeptide binding]; other site 526227004440 PHB binding site; other site 526227004441 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 526227004442 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526227004443 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526227004444 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 526227004445 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 526227004446 Permutation of conserved domain; other site 526227004447 active site 526227004448 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 526227004449 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 526227004450 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 526227004451 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 526227004452 nucleoside/Zn binding site; other site 526227004453 dimer interface [polypeptide binding]; other site 526227004454 catalytic motif [active] 526227004455 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 526227004456 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 526227004457 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 526227004458 ATP binding site [chemical binding]; other site 526227004459 substrate interface [chemical binding]; other site 526227004460 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 526227004461 dimer interface [polypeptide binding]; other site 526227004462 Citrate synthase; Region: Citrate_synt; pfam00285 526227004463 active site 526227004464 coenzyme A binding site [chemical binding]; other site 526227004465 citrylCoA binding site [chemical binding]; other site 526227004466 oxalacetate/citrate binding site [chemical binding]; other site 526227004467 catalytic triad [active] 526227004468 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 526227004469 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 526227004470 Predicted membrane protein [Function unknown]; Region: COG1470 526227004471 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 526227004472 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 526227004473 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227004474 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526227004475 Walker A/P-loop; other site 526227004476 ATP binding site [chemical binding]; other site 526227004477 Q-loop/lid; other site 526227004478 ABC transporter signature motif; other site 526227004479 Walker B; other site 526227004480 D-loop; other site 526227004481 H-loop/switch region; other site 526227004482 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 526227004483 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 526227004484 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 526227004485 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 526227004486 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526227004487 metal-binding site [ion binding] 526227004488 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526227004489 Soluble P-type ATPase [General function prediction only]; Region: COG4087 526227004490 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227004491 dimerization interface [polypeptide binding]; other site 526227004492 putative DNA binding site [nucleotide binding]; other site 526227004493 putative Zn2+ binding site [ion binding]; other site 526227004494 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526227004495 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227004496 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526227004497 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526227004498 GAF domain; Region: GAF_2; pfam13185 526227004499 GAF domain; Region: GAF_3; pfam13492 526227004500 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526227004501 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227004502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227004503 metal binding site [ion binding]; metal-binding site 526227004504 active site 526227004505 I-site; other site 526227004506 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 526227004507 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227004508 imidazolonepropionase; Validated; Region: PRK09356 526227004509 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 526227004510 active site 526227004511 urocanate hydratase; Provisional; Region: PRK05414 526227004512 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 526227004513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227004514 DNA-binding site [nucleotide binding]; DNA binding site 526227004515 UTRA domain; Region: UTRA; pfam07702 526227004516 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 526227004517 active sites [active] 526227004518 tetramer interface [polypeptide binding]; other site 526227004519 Protein of unknown function DUF58; Region: DUF58; pfam01882 526227004520 MoxR-like ATPases [General function prediction only]; Region: COG0714 526227004521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227004522 Walker A motif; other site 526227004523 ATP binding site [chemical binding]; other site 526227004524 Walker B motif; other site 526227004525 arginine finger; other site 526227004526 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 526227004527 UGMP family protein; Validated; Region: PRK09604 526227004528 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 526227004529 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 526227004530 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 526227004531 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 526227004532 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 526227004533 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 526227004534 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227004535 putative active site [active] 526227004536 putative metal binding site [ion binding]; other site 526227004537 hypothetical protein; Validated; Region: PRK00110 526227004538 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 526227004539 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 526227004540 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 526227004541 comF family protein; Region: comF; TIGR00201 526227004542 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227004543 active site 526227004544 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 526227004545 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 526227004546 active site 526227004547 Riboflavin kinase; Region: Flavokinase; pfam01687 526227004548 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 526227004549 dimer interface [polypeptide binding]; other site 526227004550 ADP-ribose binding site [chemical binding]; other site 526227004551 active site 526227004552 nudix motif; other site 526227004553 metal binding site [ion binding]; metal-binding site 526227004554 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 526227004555 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 526227004556 active site 526227004557 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 526227004558 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 526227004559 Uncharacterized conserved protein [Function unknown]; Region: COG1432 526227004560 LabA_like proteins; Region: LabA; cd10911 526227004561 putative metal binding site [ion binding]; other site 526227004562 Protein kinase domain; Region: Pkinase; pfam00069 526227004563 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526227004564 active site 526227004565 ATP binding site [chemical binding]; other site 526227004566 substrate binding site [chemical binding]; other site 526227004567 activation loop (A-loop); other site 526227004568 hypothetical protein; Provisional; Region: PRK10279 526227004569 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 526227004570 active site 526227004571 nucleophile elbow; other site 526227004572 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 526227004573 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 526227004574 Catalytic site [active] 526227004575 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 526227004576 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 526227004577 active site 526227004578 HslU subunit interaction site [polypeptide binding]; other site 526227004579 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 526227004580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227004581 Walker A motif; other site 526227004582 ATP binding site [chemical binding]; other site 526227004583 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 526227004584 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 526227004585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227004586 TPR motif; other site 526227004587 binding surface 526227004588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227004589 TPR motif; other site 526227004590 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227004591 binding surface 526227004592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227004593 Tetratricopeptide repeat; Region: TPR_16; pfam13432 526227004594 TPR motif; other site 526227004595 binding surface 526227004596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227004597 binding surface 526227004598 TPR motif; other site 526227004599 TPR repeat; Region: TPR_11; pfam13414 526227004600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 526227004601 HerA helicase [Replication, recombination, and repair]; Region: COG0433 526227004602 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 526227004603 active site 526227004604 putative DNA-binding cleft [nucleotide binding]; other site 526227004605 dimer interface [polypeptide binding]; other site 526227004606 cell division protein FtsZ; Validated; Region: PRK09330 526227004607 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 526227004608 nucleotide binding site [chemical binding]; other site 526227004609 SulA interaction site; other site 526227004610 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 526227004611 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 526227004612 nucleotide binding site [chemical binding]; other site 526227004613 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 526227004614 Cell division protein FtsA; Region: FtsA; pfam14450 526227004615 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 526227004616 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14651 526227004617 FAD binding domain; Region: FAD_binding_4; pfam01565 526227004618 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 526227004619 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 526227004620 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 526227004621 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526227004622 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526227004623 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 526227004624 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 526227004625 active site 526227004626 homodimer interface [polypeptide binding]; other site 526227004627 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 526227004628 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 526227004629 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526227004630 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 526227004631 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 526227004632 Mg++ binding site [ion binding]; other site 526227004633 putative catalytic motif [active] 526227004634 putative substrate binding site [chemical binding]; other site 526227004635 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 526227004636 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 526227004637 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526227004638 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526227004639 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 526227004640 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 526227004641 MraW methylase family; Region: Methyltransf_5; cl17771 526227004642 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 526227004643 cell division protein MraZ; Reviewed; Region: PRK00326 526227004644 MraZ protein; Region: MraZ; pfam02381 526227004645 MraZ protein; Region: MraZ; pfam02381 526227004646 isocitrate dehydrogenase; Validated; Region: PRK07362 526227004647 isocitrate dehydrogenase; Reviewed; Region: PRK07006 526227004648 CAAX protease self-immunity; Region: Abi; pfam02517 526227004649 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 526227004650 AsnC family; Region: AsnC_trans_reg; pfam01037 526227004651 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227004652 active site 526227004653 metal binding site [ion binding]; metal-binding site 526227004654 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227004655 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 526227004656 Domain of unknown function DUF11; Region: DUF11; pfam01345 526227004657 putative transposase OrfB; Reviewed; Region: PHA02517 526227004658 Integrase core domain; Region: rve; pfam00665 526227004659 Integrase core domain; Region: rve_3; pfam13683 526227004660 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227004661 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227004662 RecX family; Region: RecX; cl00936 526227004663 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227004664 MULE transposase domain; Region: MULE; pfam10551 526227004665 RecX family; Region: RecX; pfam02631 526227004666 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227004667 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 526227004668 hydrophobic ligand binding site; other site 526227004669 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 526227004670 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 526227004671 active site 526227004672 HIGH motif; other site 526227004673 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 526227004674 KMSKS motif; other site 526227004675 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 526227004676 tRNA binding surface [nucleotide binding]; other site 526227004677 anticodon binding site; other site 526227004678 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 526227004679 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 526227004680 putative transposase OrfB; Reviewed; Region: PHA02517 526227004681 Integrase core domain; Region: rve; pfam00665 526227004682 Integrase core domain; Region: rve_3; pfam13683 526227004683 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 526227004684 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 526227004685 active site 526227004686 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 526227004687 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 526227004688 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 526227004689 active site 526227004690 FMN binding site [chemical binding]; other site 526227004691 substrate binding site [chemical binding]; other site 526227004692 3Fe-4S cluster binding site [ion binding]; other site 526227004693 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 526227004694 domain_subunit interface; other site 526227004695 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 526227004696 heme-binding site [chemical binding]; other site 526227004697 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 526227004698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227004699 motif II; other site 526227004700 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14603 526227004701 RuvA N terminal domain; Region: RuvA_N; pfam01330 526227004702 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 526227004703 enoyl-CoA hydratase; Provisional; Region: PRK06688 526227004704 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227004705 substrate binding site [chemical binding]; other site 526227004706 oxyanion hole (OAH) forming residues; other site 526227004707 trimer interface [polypeptide binding]; other site 526227004708 DinB superfamily; Region: DinB_2; pfam12867 526227004709 enoyl-CoA hydratase; Provisional; Region: PRK05862 526227004710 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227004711 substrate binding site [chemical binding]; other site 526227004712 oxyanion hole (OAH) forming residues; other site 526227004713 trimer interface [polypeptide binding]; other site 526227004714 Cupin domain; Region: Cupin_2; pfam07883 526227004715 aspartate kinase; Reviewed; Region: PRK06635 526227004716 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 526227004717 putative nucleotide binding site [chemical binding]; other site 526227004718 putative catalytic residues [active] 526227004719 putative Mg ion binding site [ion binding]; other site 526227004720 putative aspartate binding site [chemical binding]; other site 526227004721 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 526227004722 putative allosteric regulatory site; other site 526227004723 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 526227004724 putative allosteric regulatory residue; other site 526227004725 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227004726 active site 526227004727 malate dehydrogenase; Provisional; Region: PRK05442 526227004728 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 526227004729 NAD(P) binding site [chemical binding]; other site 526227004730 dimer interface [polypeptide binding]; other site 526227004731 malate binding site [chemical binding]; other site 526227004732 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 526227004733 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 526227004734 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 526227004735 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 526227004736 B12 binding site [chemical binding]; other site 526227004737 cobalt ligand [ion binding]; other site 526227004738 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 526227004739 S-formylglutathione hydrolase; Region: PLN02442 526227004740 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227004741 MULE transposase domain; Region: MULE; pfam10551 526227004742 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526227004743 CoenzymeA binding site [chemical binding]; other site 526227004744 subunit interaction site [polypeptide binding]; other site 526227004745 PHB binding site; other site 526227004746 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 526227004747 Recombination protein O N terminal; Region: RecO_N; pfam11967 526227004748 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 526227004749 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 526227004750 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 526227004751 catalytic residues [active] 526227004752 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 526227004753 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227004754 putative active site [active] 526227004755 metal binding site [ion binding]; metal-binding site 526227004756 homodimer binding site [polypeptide binding]; other site 526227004757 Src Homology 3 domain superfamily; Region: SH3; cl17036 526227004758 peptide ligand binding site [polypeptide binding]; other site 526227004759 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 526227004760 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 526227004761 Dodecin; Region: Dodecin; pfam07311 526227004762 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526227004763 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227004764 CTP synthetase; Validated; Region: pyrG; PRK05380 526227004765 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 526227004766 Catalytic site [active] 526227004767 active site 526227004768 UTP binding site [chemical binding]; other site 526227004769 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 526227004770 active site 526227004771 putative oxyanion hole; other site 526227004772 catalytic triad [active] 526227004773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227004774 Walker A motif; other site 526227004775 ATP binding site [chemical binding]; other site 526227004776 Walker B motif; other site 526227004777 arginine finger; other site 526227004778 GAF domain; Region: GAF; cl17456 526227004779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227004780 Zn2+ binding site [ion binding]; other site 526227004781 Mg2+ binding site [ion binding]; other site 526227004782 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227004783 MULE transposase domain; Region: MULE; pfam10551 526227004784 PIN domain; Region: PIN_3; pfam13470 526227004785 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 526227004786 Restriction endonuclease; Region: Mrr_cat; pfam04471 526227004787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 526227004788 Predicted transcriptional regulator [Transcription]; Region: COG2932 526227004789 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 526227004790 Catalytic site [active] 526227004791 Helix-turn-helix domain; Region: HTH_17; pfam12728 526227004792 Helix-turn-helix domain; Region: HTH_17; pfam12728 526227004793 arginine decarboxylase, biosynthetic; Region: speA; TIGR01273 526227004794 Helitron helicase-like domain at N-terminus; Region: Helitron_like_N; pfam14214 526227004795 hypothetical protein; Reviewed; Region: PRK00024 526227004796 Protein of unknown function (DUF497); Region: DUF497; cl01108 526227004797 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227004798 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 526227004799 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526227004800 catalytic residue [active] 526227004801 putative transposase OrfB; Reviewed; Region: PHA02517 526227004802 Integrase core domain; Region: rve; pfam00665 526227004803 Integrase core domain; Region: rve_3; pfam13683 526227004804 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 526227004805 Predicted membrane protein [Function unknown]; Region: COG3748 526227004806 Protein of unknown function (DUF989); Region: DUF989; pfam06181 526227004807 Cytochrome c; Region: Cytochrom_C; pfam00034 526227004808 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 526227004809 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227004810 active site 526227004811 metal binding site [ion binding]; metal-binding site 526227004812 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 526227004813 active site 526227004814 homotetramer interface [polypeptide binding]; other site 526227004815 allantoate amidohydrolase; Reviewed; Region: PRK09290 526227004816 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 526227004817 active site 526227004818 metal binding site [ion binding]; metal-binding site 526227004819 dimer interface [polypeptide binding]; other site 526227004820 allantoinase; Provisional; Region: PRK06189 526227004821 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 526227004822 active site 526227004823 hypothetical protein; Provisional; Region: PRK11171 526227004824 Cupin domain; Region: Cupin_2; pfam07883 526227004825 Cupin domain; Region: Cupin_2; pfam07883 526227004826 allantoate amidohydrolase; Reviewed; Region: PRK09290 526227004827 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 526227004828 active site 526227004829 metal binding site [ion binding]; metal-binding site 526227004830 dimer interface [polypeptide binding]; other site 526227004831 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 526227004832 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 526227004833 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 526227004834 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 526227004835 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 526227004836 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 526227004837 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 526227004838 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 526227004839 XdhC Rossmann domain; Region: XdhC_C; pfam13478 526227004840 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 526227004841 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 526227004842 Walker A/P-loop; other site 526227004843 ATP binding site [chemical binding]; other site 526227004844 Q-loop/lid; other site 526227004845 ABC transporter signature motif; other site 526227004846 Walker B; other site 526227004847 D-loop; other site 526227004848 H-loop/switch region; other site 526227004849 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 526227004850 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227004851 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526227004852 TM-ABC transporter signature motif; other site 526227004853 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227004854 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526227004855 TM-ABC transporter signature motif; other site 526227004856 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 526227004857 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 526227004858 putative ligand binding site [chemical binding]; other site 526227004859 guanine deaminase; Provisional; Region: PRK09228 526227004860 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227004861 active site 526227004862 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 526227004863 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227004864 inhibitor-cofactor binding pocket; inhibition site 526227004865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227004866 catalytic residue [active] 526227004867 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 526227004868 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 526227004869 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 526227004870 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526227004871 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 526227004872 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227004873 substrate binding site [chemical binding]; other site 526227004874 oxyanion hole (OAH) forming residues; other site 526227004875 trimer interface [polypeptide binding]; other site 526227004876 Protein of unknown function (DUF433); Region: DUF433; pfam04255 526227004877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 526227004878 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 526227004879 active site 526227004880 catalytic triad [active] 526227004881 oxyanion hole [active] 526227004882 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 526227004883 active site 2 [active] 526227004884 active site 1 [active] 526227004885 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 526227004886 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526227004887 dimer interface [polypeptide binding]; other site 526227004888 active site 526227004889 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 526227004890 ArsC family; Region: ArsC; pfam03960 526227004891 catalytic residue [active] 526227004892 putative transposase OrfB; Reviewed; Region: PHA02517 526227004893 Integrase core domain; Region: rve; pfam00665 526227004894 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526227004895 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 526227004896 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227004897 active site 526227004898 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227004899 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227004900 metal binding site [ion binding]; metal-binding site 526227004901 active site 526227004902 I-site; other site 526227004903 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 526227004904 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 526227004905 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 526227004906 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 526227004907 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 526227004908 catalytic triad [active] 526227004909 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 526227004910 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227004911 active site 526227004912 dimer interface [polypeptide binding]; other site 526227004913 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 526227004914 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 526227004915 active site 526227004916 HIGH motif; other site 526227004917 KMSKS motif; other site 526227004918 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 526227004919 tRNA binding surface [nucleotide binding]; other site 526227004920 anticodon binding site; other site 526227004921 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 526227004922 dimer interface [polypeptide binding]; other site 526227004923 putative tRNA-binding site [nucleotide binding]; other site 526227004924 putative transposase OrfB; Reviewed; Region: PHA02517 526227004925 Integrase core domain; Region: rve; pfam00665 526227004926 Integrase core domain; Region: rve_3; pfam13683 526227004927 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 526227004928 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 526227004929 calcium binding site 2 [ion binding]; other site 526227004930 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 526227004931 active site 526227004932 catalytic triad [active] 526227004933 calcium binding site 1 [ion binding]; other site 526227004934 Homeodomain-like domain; Region: HTH_23; cl17451 526227004935 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 526227004936 SpoVR like protein; Region: SpoVR; pfam04293 526227004937 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227004938 metal ion-dependent adhesion site (MIDAS); other site 526227004939 PrkA AAA domain; Region: AAA_PrkA; smart00763 526227004940 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 526227004941 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 526227004942 homotrimer interaction site [polypeptide binding]; other site 526227004943 active site 526227004944 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 526227004945 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 526227004946 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 526227004947 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 526227004948 dimer interface [polypeptide binding]; other site 526227004949 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227004950 active site 526227004951 Uncharacterized conserved protein [Function unknown]; Region: COG3375 526227004952 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 526227004953 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 526227004954 active site 526227004955 octamer interface [polypeptide binding]; other site 526227004956 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 526227004957 putative active site [active] 526227004958 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 526227004959 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 526227004960 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 526227004961 seryl-tRNA synthetase; Provisional; Region: PRK05431 526227004962 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 526227004963 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 526227004964 dimer interface [polypeptide binding]; other site 526227004965 active site 526227004966 motif 1; other site 526227004967 motif 2; other site 526227004968 motif 3; other site 526227004969 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 526227004970 tyrosine decarboxylase; Region: PLN02880 526227004971 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227004972 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227004973 catalytic residue [active] 526227004974 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 526227004975 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 526227004976 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 526227004977 NodB motif; other site 526227004978 putative active site [active] 526227004979 putative catalytic site [active] 526227004980 putative Zn binding site [ion binding]; other site 526227004981 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227004982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526227004983 active site 526227004984 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 526227004985 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227004986 putative ADP-binding pocket [chemical binding]; other site 526227004987 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 526227004988 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 526227004989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227004990 catalytic residue [active] 526227004991 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 526227004992 substrate binding site [chemical binding]; other site 526227004993 active site 526227004994 catalytic residues [active] 526227004995 heterodimer interface [polypeptide binding]; other site 526227004996 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 526227004997 DNA methylase; Region: N6_N4_Mtase; pfam01555 526227004998 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526227004999 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 526227005000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227005001 active site 526227005002 phosphorylation site [posttranslational modification] 526227005003 intermolecular recognition site; other site 526227005004 dimerization interface [polypeptide binding]; other site 526227005005 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 526227005006 HAMP domain; Region: HAMP; pfam00672 526227005007 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 526227005008 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 526227005009 dimer interface [polypeptide binding]; other site 526227005010 putative CheW interface [polypeptide binding]; other site 526227005011 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 526227005012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 526227005013 dimerization interface [polypeptide binding]; other site 526227005014 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 526227005015 dimer interface [polypeptide binding]; other site 526227005016 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 526227005017 putative CheW interface [polypeptide binding]; other site 526227005018 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 526227005019 putative binding surface; other site 526227005020 active site 526227005021 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 526227005022 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 526227005023 putative binding surface; other site 526227005024 active site 526227005025 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 526227005026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227005027 ATP binding site [chemical binding]; other site 526227005028 Mg2+ binding site [ion binding]; other site 526227005029 G-X-G motif; other site 526227005030 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 526227005031 Response regulator receiver domain; Region: Response_reg; pfam00072 526227005032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227005033 active site 526227005034 phosphorylation site [posttranslational modification] 526227005035 intermolecular recognition site; other site 526227005036 dimerization interface [polypeptide binding]; other site 526227005037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 526227005038 phosphorylation site [posttranslational modification] 526227005039 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 526227005040 Response regulator receiver domain; Region: Response_reg; pfam00072 526227005041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227005042 active site 526227005043 phosphorylation site [posttranslational modification] 526227005044 intermolecular recognition site; other site 526227005045 dimerization interface [polypeptide binding]; other site 526227005046 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 526227005047 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 526227005048 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 526227005049 substrate binding site [chemical binding]; other site 526227005050 dimer interface [polypeptide binding]; other site 526227005051 NADP binding site [chemical binding]; other site 526227005052 catalytic residues [active] 526227005053 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 526227005054 substrate binding site [chemical binding]; other site 526227005055 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 526227005056 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 526227005057 alpha subunit interface [polypeptide binding]; other site 526227005058 TPP binding site [chemical binding]; other site 526227005059 heterodimer interface [polypeptide binding]; other site 526227005060 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526227005061 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 526227005062 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 526227005063 TPP-binding site [chemical binding]; other site 526227005064 tetramer interface [polypeptide binding]; other site 526227005065 heterodimer interface [polypeptide binding]; other site 526227005066 phosphorylation loop region [posttranslational modification] 526227005067 putative transposase OrfB; Reviewed; Region: PHA02517 526227005068 Integrase core domain; Region: rve; pfam00665 526227005069 Integrase core domain; Region: rve_3; pfam13683 526227005070 trigger factor; Region: tig; TIGR00115 526227005071 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 526227005072 Clp protease; Region: CLP_protease; pfam00574 526227005073 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 526227005074 oligomer interface [polypeptide binding]; other site 526227005075 active site residues [active] 526227005076 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 526227005077 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 526227005078 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 526227005079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227005080 Walker A motif; other site 526227005081 ATP binding site [chemical binding]; other site 526227005082 Walker B motif; other site 526227005083 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 526227005084 Thioredoxin; Region: Thioredoxin_4; pfam13462 526227005085 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 526227005086 spermidine synthase; Provisional; Region: PRK00811 526227005087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227005088 S-adenosylmethionine binding site [chemical binding]; other site 526227005089 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 526227005090 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 526227005091 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 526227005092 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 526227005093 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 526227005094 Occludin homology domain; Region: Occludin_ELL; pfam07303 526227005095 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 526227005096 Protein of unknown function, DUF606; Region: DUF606; pfam04657 526227005097 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 526227005098 allantoate amidohydrolase; Reviewed; Region: PRK09290 526227005099 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 526227005100 active site 526227005101 metal binding site [ion binding]; metal-binding site 526227005102 dimer interface [polypeptide binding]; other site 526227005103 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 526227005104 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526227005105 hypothetical protein; Provisional; Region: PRK06062 526227005106 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227005107 inhibitor-cofactor binding pocket; inhibition site 526227005108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227005109 catalytic residue [active] 526227005110 Hemerythrin; Region: Hemerythrin; cd12107 526227005111 Fe binding site [ion binding]; other site 526227005112 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 526227005113 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 526227005114 tetrameric interface [polypeptide binding]; other site 526227005115 NAD binding site [chemical binding]; other site 526227005116 catalytic residues [active] 526227005117 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 526227005118 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 526227005119 active site clefts [active] 526227005120 zinc binding site [ion binding]; other site 526227005121 dimer interface [polypeptide binding]; other site 526227005122 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 526227005123 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 526227005124 quinone interaction residues [chemical binding]; other site 526227005125 active site 526227005126 catalytic residues [active] 526227005127 FMN binding site [chemical binding]; other site 526227005128 substrate binding site [chemical binding]; other site 526227005129 dihydroorotase; Validated; Region: pyrC; PRK09357 526227005130 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227005131 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 526227005132 active site 526227005133 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 526227005134 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 526227005135 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 526227005136 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 526227005137 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227005138 active site 526227005139 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 526227005140 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 526227005141 active site 526227005142 metal binding site [ion binding]; metal-binding site 526227005143 DNA binding site [nucleotide binding] 526227005144 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 526227005145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227005146 Walker A/P-loop; other site 526227005147 ATP binding site [chemical binding]; other site 526227005148 Q-loop/lid; other site 526227005149 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 526227005150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227005151 Walker B; other site 526227005152 D-loop; other site 526227005153 H-loop/switch region; other site 526227005154 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 526227005155 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 526227005156 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 526227005157 Dimer interface [polypeptide binding]; other site 526227005158 anticodon binding site; other site 526227005159 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 526227005160 motif 1; other site 526227005161 dimer interface [polypeptide binding]; other site 526227005162 active site 526227005163 motif 2; other site 526227005164 motif 3; other site 526227005165 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 526227005166 active site 526227005167 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 526227005168 Phospholipid methyltransferase; Region: PEMT; cl17370 526227005169 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 526227005170 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 526227005171 malonyl-CoA binding site [chemical binding]; other site 526227005172 dimer interface [polypeptide binding]; other site 526227005173 active site 526227005174 product binding site; other site 526227005175 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 526227005176 FMN binding site [chemical binding]; other site 526227005177 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 526227005178 dimer interface [polypeptide binding]; other site 526227005179 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227005180 MULE transposase domain; Region: MULE; pfam10551 526227005181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227005182 non-specific DNA binding site [nucleotide binding]; other site 526227005183 salt bridge; other site 526227005184 sequence-specific DNA binding site [nucleotide binding]; other site 526227005185 Predicted transcriptional regulator [Transcription]; Region: COG2932 526227005186 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 526227005187 Catalytic site [active] 526227005188 Integrase core domain; Region: rve; pfam00665 526227005189 AAA ATPase domain; Region: AAA_16; pfam13191 526227005190 AAA domain; Region: AAA_22; pfam13401 526227005191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227005192 putative DNA binding site [nucleotide binding]; other site 526227005193 putative Zn2+ binding site [ion binding]; other site 526227005194 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 526227005195 Terminase-like family; Region: Terminase_6; pfam03237 526227005196 Protein of unknown function (DUF935); Region: DUF935; pfam06074 526227005197 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 526227005198 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 526227005199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227005200 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 526227005201 Probable transposase; Region: OrfB_IS605; pfam01385 526227005202 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227005203 Domain found in IF2B/IF5; Region: eIF-5_eIF-2B; cl17014 526227005204 Transposase IS200 like; Region: Y1_Tnp; pfam01797 526227005205 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 526227005206 Baseplate J-like protein; Region: Baseplate_J; pfam04865 526227005207 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227005208 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227005209 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 526227005210 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 526227005211 active site 526227005212 substrate binding site [chemical binding]; other site 526227005213 metal binding site [ion binding]; metal-binding site 526227005214 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 526227005215 Part of AAA domain; Region: AAA_19; pfam13245 526227005216 Family description; Region: UvrD_C_2; pfam13538 526227005217 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 526227005218 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 526227005219 23S rRNA interface [nucleotide binding]; other site 526227005220 L3 interface [polypeptide binding]; other site 526227005221 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 526227005222 aromatic arch; other site 526227005223 DCoH dimer interaction site [polypeptide binding]; other site 526227005224 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 526227005225 DCoH tetramer interaction site [polypeptide binding]; other site 526227005226 substrate binding site [chemical binding]; other site 526227005227 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 526227005228 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 526227005229 TPP-binding site [chemical binding]; other site 526227005230 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 526227005231 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 526227005232 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526227005233 E3 interaction surface; other site 526227005234 lipoyl attachment site [posttranslational modification]; other site 526227005235 e3 binding domain; Region: E3_binding; pfam02817 526227005236 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 526227005237 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 526227005238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526227005239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227005240 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 526227005241 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 526227005242 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 526227005243 active site 526227005244 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 526227005245 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 526227005246 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 526227005247 substrate binding pocket [chemical binding]; other site 526227005248 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 526227005249 B12 binding site [chemical binding]; other site 526227005250 cobalt ligand [ion binding]; other site 526227005251 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 526227005252 hypothetical protein; Provisional; Region: PRK08609 526227005253 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 526227005254 active site 526227005255 primer binding site [nucleotide binding]; other site 526227005256 NTP binding site [chemical binding]; other site 526227005257 metal binding triad [ion binding]; metal-binding site 526227005258 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 526227005259 active site 526227005260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227005261 S-adenosylmethionine binding site [chemical binding]; other site 526227005262 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526227005263 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 526227005264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227005265 Coenzyme A binding pocket [chemical binding]; other site 526227005266 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 526227005267 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 526227005268 PhoU domain; Region: PhoU; pfam01895 526227005269 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 526227005270 hydroxyglutarate oxidase; Provisional; Region: PRK11728 526227005271 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 526227005272 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526227005273 Walker A/P-loop; other site 526227005274 ATP binding site [chemical binding]; other site 526227005275 Q-loop/lid; other site 526227005276 ABC transporter signature motif; other site 526227005277 Walker B; other site 526227005278 D-loop; other site 526227005279 H-loop/switch region; other site 526227005280 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 526227005281 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 526227005282 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 526227005283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227005284 Walker A/P-loop; other site 526227005285 ATP binding site [chemical binding]; other site 526227005286 Q-loop/lid; other site 526227005287 ABC transporter signature motif; other site 526227005288 Walker B; other site 526227005289 D-loop; other site 526227005290 H-loop/switch region; other site 526227005291 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 526227005292 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 526227005293 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227005294 active site 526227005295 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 526227005296 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 526227005297 active site 526227005298 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 526227005299 protein binding site [polypeptide binding]; other site 526227005300 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 526227005301 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 526227005302 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 526227005303 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 526227005304 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 526227005305 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 526227005306 ribosome recycling factor; Reviewed; Region: frr; PRK00083 526227005307 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 526227005308 hinge region; other site 526227005309 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 526227005310 putative nucleotide binding site [chemical binding]; other site 526227005311 uridine monophosphate binding site [chemical binding]; other site 526227005312 homohexameric interface [polypeptide binding]; other site 526227005313 elongation factor Ts; Reviewed; Region: tsf; PRK12332 526227005314 UBA/TS-N domain; Region: UBA; pfam00627 526227005315 Elongation factor TS; Region: EF_TS; pfam00889 526227005316 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 526227005317 rRNA interaction site [nucleotide binding]; other site 526227005318 S8 interaction site; other site 526227005319 putative laminin-1 binding site; other site 526227005320 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227005321 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 526227005322 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 526227005323 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 526227005324 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 526227005325 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 526227005326 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 526227005327 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 526227005328 active site 526227005329 catalytic site [active] 526227005330 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 526227005331 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 526227005332 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526227005333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227005334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 526227005335 conserved hypothetical protein; Region: TIGR03492 526227005336 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 526227005337 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227005338 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227005339 ATP binding site [chemical binding]; other site 526227005340 putative Mg++ binding site [ion binding]; other site 526227005341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227005342 nucleotide binding region [chemical binding]; other site 526227005343 ATP-binding site [chemical binding]; other site 526227005344 TRCF domain; Region: TRCF; pfam03461 526227005345 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 526227005346 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227005347 putative transposase OrfB; Reviewed; Region: PHA02517 526227005348 Integrase core domain; Region: rve; pfam00665 526227005349 Integrase core domain; Region: rve_3; pfam13683 526227005350 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 526227005351 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 526227005352 Cytochrome c552; Region: Cytochrom_C552; pfam02335 526227005353 Acetokinase family; Region: Acetate_kinase; cl17229 526227005354 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 526227005355 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 526227005356 active site 526227005357 catalytic triad [active] 526227005358 Predicted amidohydrolase [General function prediction only]; Region: COG0388 526227005359 dimer interface [polypeptide binding]; other site 526227005360 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 526227005361 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 526227005362 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 526227005363 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 526227005364 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 526227005365 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 526227005366 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 526227005367 homodimer interface [polypeptide binding]; other site 526227005368 substrate-cofactor binding pocket; other site 526227005369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227005370 catalytic residue [active] 526227005371 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227005372 putative transposase OrfB; Reviewed; Region: PHA02517 526227005373 Integrase core domain; Region: rve; pfam00665 526227005374 Integrase core domain; Region: rve_3; pfam13683 526227005375 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 526227005376 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227005377 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 526227005378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227005379 dimer interface [polypeptide binding]; other site 526227005380 conserved gate region; other site 526227005381 putative PBP binding loops; other site 526227005382 ABC-ATPase subunit interface; other site 526227005383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227005384 dimer interface [polypeptide binding]; other site 526227005385 conserved gate region; other site 526227005386 putative PBP binding loops; other site 526227005387 ABC-ATPase subunit interface; other site 526227005388 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227005389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227005390 Walker A/P-loop; other site 526227005391 ATP binding site [chemical binding]; other site 526227005392 Q-loop/lid; other site 526227005393 ABC transporter signature motif; other site 526227005394 Walker B; other site 526227005395 D-loop; other site 526227005396 H-loop/switch region; other site 526227005397 TOBE domain; Region: TOBE_2; pfam08402 526227005398 Predicted permeases [General function prediction only]; Region: COG0679 526227005399 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 526227005400 RNA methyltransferase, RsmE family; Region: TIGR00046 526227005401 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 526227005402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227005403 S-adenosylmethionine binding site [chemical binding]; other site 526227005404 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526227005405 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 526227005406 intersubunit interface [polypeptide binding]; other site 526227005407 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 526227005408 metal binding site 2 [ion binding]; metal-binding site 526227005409 putative DNA binding helix; other site 526227005410 metal binding site 1 [ion binding]; metal-binding site 526227005411 dimer interface [polypeptide binding]; other site 526227005412 structural Zn2+ binding site [ion binding]; other site 526227005413 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526227005414 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 526227005415 substrate binding site [chemical binding]; other site 526227005416 ATP binding site [chemical binding]; other site 526227005417 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 526227005418 tetramer interface [polypeptide binding]; other site 526227005419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227005420 catalytic residue [active] 526227005421 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 526227005422 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 526227005423 tetramer interface [polypeptide binding]; other site 526227005424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227005425 catalytic residue [active] 526227005426 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 526227005427 lipoyl attachment site [posttranslational modification]; other site 526227005428 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 526227005429 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 526227005430 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 526227005431 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 526227005432 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 526227005433 G1 box; other site 526227005434 GTP/Mg2+ binding site [chemical binding]; other site 526227005435 G2 box; other site 526227005436 Switch I region; other site 526227005437 G3 box; other site 526227005438 Switch II region; other site 526227005439 G4 box; other site 526227005440 G5 box; other site 526227005441 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 526227005442 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 526227005443 hypothetical protein; Provisional; Region: PRK06446 526227005444 metal binding site [ion binding]; metal-binding site 526227005445 dimer interface [polypeptide binding]; other site 526227005446 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 526227005447 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526227005448 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 526227005449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227005450 FeS/SAM binding site; other site 526227005451 HemN C-terminal domain; Region: HemN_C; pfam06969 526227005452 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227005453 MULE transposase domain; Region: MULE; pfam10551 526227005454 trehalose synthase; Region: treS_nterm; TIGR02456 526227005455 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 526227005456 active site 526227005457 catalytic site [active] 526227005458 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 526227005459 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 526227005460 catalytic residues [active] 526227005461 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 526227005462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 526227005463 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 526227005464 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 526227005465 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 526227005466 RNase E interface [polypeptide binding]; other site 526227005467 trimer interface [polypeptide binding]; other site 526227005468 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 526227005469 RNase E interface [polypeptide binding]; other site 526227005470 trimer interface [polypeptide binding]; other site 526227005471 active site 526227005472 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 526227005473 putative nucleic acid binding region [nucleotide binding]; other site 526227005474 G-X-X-G motif; other site 526227005475 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 526227005476 RNA binding site [nucleotide binding]; other site 526227005477 domain interface; other site 526227005478 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 526227005479 16S/18S rRNA binding site [nucleotide binding]; other site 526227005480 S13e-L30e interaction site [polypeptide binding]; other site 526227005481 25S rRNA binding site [nucleotide binding]; other site 526227005482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227005483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227005484 putative substrate translocation pore; other site 526227005485 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 526227005486 Low-spin heme binding site [chemical binding]; other site 526227005487 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 526227005488 D-pathway; other site 526227005489 Putative water exit pathway; other site 526227005490 Binuclear center (active site) [active] 526227005491 K-pathway; other site 526227005492 Putative proton exit pathway; other site 526227005493 Cytochrome C oxidase subunit II, transmembrane; Region: COX2-transmemb; pfam09125 526227005494 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 526227005495 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 526227005496 Cytochrome c oxidase subunit IIa family; Region: CoxIIa; pfam08113 526227005497 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 526227005498 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 526227005499 TPP-binding site [chemical binding]; other site 526227005500 dimer interface [polypeptide binding]; other site 526227005501 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 526227005502 PYR/PP interface [polypeptide binding]; other site 526227005503 dimer interface [polypeptide binding]; other site 526227005504 TPP binding site [chemical binding]; other site 526227005505 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526227005506 elongation factor P; Validated; Region: PRK00529 526227005507 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 526227005508 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 526227005509 RNA binding site [nucleotide binding]; other site 526227005510 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 526227005511 RNA binding site [nucleotide binding]; other site 526227005512 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 526227005513 carboxyltransferase (CT) interaction site; other site 526227005514 biotinylation site [posttranslational modification]; other site 526227005515 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 526227005516 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526227005517 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 526227005518 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 526227005519 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 526227005520 ADP-ribose binding site [chemical binding]; other site 526227005521 dimer interface [polypeptide binding]; other site 526227005522 active site 526227005523 nudix motif; other site 526227005524 metal binding site [ion binding]; metal-binding site 526227005525 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 526227005526 DHH family; Region: DHH; pfam01368 526227005527 FOG: CBS domain [General function prediction only]; Region: COG0517 526227005528 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 526227005529 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 526227005530 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 526227005531 active site 526227005532 NTP binding site [chemical binding]; other site 526227005533 metal binding triad [ion binding]; metal-binding site 526227005534 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 526227005535 active site 526227005536 putative substrate binding region [chemical binding]; other site 526227005537 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 526227005538 Peptidase family M50; Region: Peptidase_M50; pfam02163 526227005539 active site 526227005540 putative substrate binding region [chemical binding]; other site 526227005541 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 526227005542 endonuclease IV; Provisional; Region: PRK01060 526227005543 AP (apurinic/apyrimidinic) site pocket; other site 526227005544 DNA interaction; other site 526227005545 Metal-binding active site; metal-binding site 526227005546 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526227005547 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 526227005548 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 526227005549 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 526227005550 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 526227005551 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 526227005552 active site 526227005553 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 526227005554 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526227005555 active site 526227005556 HIGH motif; other site 526227005557 nucleotide binding site [chemical binding]; other site 526227005558 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 526227005559 active site 526227005560 KMSKS motif; other site 526227005561 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 526227005562 tRNA binding surface [nucleotide binding]; other site 526227005563 anticodon binding site; other site 526227005564 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 526227005565 active site 526227005566 intersubunit interactions; other site 526227005567 catalytic residue [active] 526227005568 transcription termination factor Rho; Provisional; Region: rho; PRK09376 526227005569 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 526227005570 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 526227005571 RNA binding site [nucleotide binding]; other site 526227005572 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 526227005573 Walker A motif; other site 526227005574 ATP binding site [chemical binding]; other site 526227005575 Walker B motif; other site 526227005576 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526227005577 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 526227005578 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526227005579 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526227005580 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526227005581 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227005582 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 526227005583 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 526227005584 active site 526227005585 multimer interface [polypeptide binding]; other site 526227005586 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 526227005587 predicted active site [active] 526227005588 catalytic triad [active] 526227005589 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 526227005590 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 526227005591 putative dimer interface [polypeptide binding]; other site 526227005592 putative anticodon binding site; other site 526227005593 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 526227005594 homodimer interface [polypeptide binding]; other site 526227005595 motif 1; other site 526227005596 motif 2; other site 526227005597 active site 526227005598 motif 3; other site 526227005599 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 526227005600 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 526227005601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 526227005602 active site 526227005603 motif I; other site 526227005604 motif II; other site 526227005605 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 526227005606 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 526227005607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227005608 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 526227005609 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 526227005610 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 526227005611 dimer interface [polypeptide binding]; other site 526227005612 anticodon binding site; other site 526227005613 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 526227005614 homodimer interface [polypeptide binding]; other site 526227005615 motif 1; other site 526227005616 active site 526227005617 motif 2; other site 526227005618 GAD domain; Region: GAD; pfam02938 526227005619 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 526227005620 motif 3; other site 526227005621 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 526227005622 SmpB-tmRNA interface; other site 526227005623 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 526227005624 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526227005625 active site 526227005626 metal binding site [ion binding]; metal-binding site 526227005627 Sporulation and spore germination; Region: Germane; pfam10646 526227005628 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 526227005629 Walker A/P-loop; other site 526227005630 ATP binding site [chemical binding]; other site 526227005631 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 526227005632 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 526227005633 ABC transporter signature motif; other site 526227005634 Walker B; other site 526227005635 D-loop; other site 526227005636 H-loop/switch region; other site 526227005637 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526227005638 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 526227005639 active site 526227005640 DNA binding site [nucleotide binding] 526227005641 Int/Topo IB signature motif; other site 526227005642 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 526227005643 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 526227005644 dimer interface [polypeptide binding]; other site 526227005645 motif 1; other site 526227005646 active site 526227005647 motif 2; other site 526227005648 motif 3; other site 526227005649 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 526227005650 anticodon binding site; other site 526227005651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227005652 dimer interface [polypeptide binding]; other site 526227005653 conserved gate region; other site 526227005654 putative PBP binding loops; other site 526227005655 ABC-ATPase subunit interface; other site 526227005656 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227005657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227005658 dimer interface [polypeptide binding]; other site 526227005659 conserved gate region; other site 526227005660 putative PBP binding loops; other site 526227005661 ABC-ATPase subunit interface; other site 526227005662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227005663 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526227005664 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 526227005665 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 526227005666 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 526227005667 Phosphoglycerate kinase; Region: PGK; pfam00162 526227005668 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 526227005669 substrate binding site [chemical binding]; other site 526227005670 hinge regions; other site 526227005671 ADP binding site [chemical binding]; other site 526227005672 catalytic site [active] 526227005673 triosephosphate isomerase; Provisional; Region: PRK14567 526227005674 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 526227005675 substrate binding site [chemical binding]; other site 526227005676 dimer interface [polypeptide binding]; other site 526227005677 catalytic triad [active] 526227005678 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 526227005679 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227005680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227005681 homodimer interface [polypeptide binding]; other site 526227005682 catalytic residue [active] 526227005683 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 526227005684 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 526227005685 putative dimer interface [polypeptide binding]; other site 526227005686 putative transposase OrfB; Reviewed; Region: PHA02517 526227005687 Integrase core domain; Region: rve; pfam00665 526227005688 Integrase core domain; Region: rve_3; pfam13683 526227005689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227005690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526227005691 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 526227005692 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 526227005693 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 526227005694 active site 526227005695 Zn binding site [ion binding]; other site 526227005696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227005697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526227005698 HD supefamily hydrolase [General function prediction only]; Region: COG3294 526227005699 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227005700 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 526227005701 substrate binding site [chemical binding]; other site 526227005702 oxyanion hole (OAH) forming residues; other site 526227005703 trimer interface [polypeptide binding]; other site 526227005704 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 526227005705 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 526227005706 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 526227005707 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 526227005708 Walker A/P-loop; other site 526227005709 ATP binding site [chemical binding]; other site 526227005710 Q-loop/lid; other site 526227005711 ABC transporter signature motif; other site 526227005712 Walker B; other site 526227005713 D-loop; other site 526227005714 H-loop/switch region; other site 526227005715 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 526227005716 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227005717 ligand binding site [chemical binding]; other site 526227005718 flexible hinge region; other site 526227005719 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 526227005720 putative switch regulator; other site 526227005721 non-specific DNA interactions [nucleotide binding]; other site 526227005722 DNA binding site [nucleotide binding] 526227005723 sequence specific DNA binding site [nucleotide binding]; other site 526227005724 putative cAMP binding site [chemical binding]; other site 526227005725 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 526227005726 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 526227005727 substrate binding site [chemical binding]; other site 526227005728 hexamer interface [polypeptide binding]; other site 526227005729 metal binding site [ion binding]; metal-binding site 526227005730 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 526227005731 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 526227005732 hypothetical protein; Provisional; Region: PRK08201 526227005733 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 526227005734 metal binding site [ion binding]; metal-binding site 526227005735 putative dimer interface [polypeptide binding]; other site 526227005736 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 526227005737 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526227005738 DNA binding residues [nucleotide binding] 526227005739 putative dimer interface [polypeptide binding]; other site 526227005740 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 526227005741 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526227005742 DNA binding residues [nucleotide binding] 526227005743 putative dimer interface [polypeptide binding]; other site 526227005744 malate dehydrogenase; Provisional; Region: PRK13529 526227005745 Malic enzyme, N-terminal domain; Region: malic; pfam00390 526227005746 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 526227005747 NAD(P) binding site [chemical binding]; other site 526227005748 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 526227005749 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526227005750 NAD(P) binding site [chemical binding]; other site 526227005751 catalytic residues [active] 526227005752 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 526227005753 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 526227005754 active site 526227005755 (T/H)XGH motif; other site 526227005756 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 526227005757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227005758 S-adenosylmethionine binding site [chemical binding]; other site 526227005759 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 526227005760 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 526227005761 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 526227005762 YibE/F-like protein; Region: YibE_F; pfam07907 526227005763 G8 domain; Region: G8; pfam10162 526227005764 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 526227005765 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 526227005766 nucleotide binding pocket [chemical binding]; other site 526227005767 K-X-D-G motif; other site 526227005768 catalytic site [active] 526227005769 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 526227005770 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 526227005771 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 526227005772 Dimer interface [polypeptide binding]; other site 526227005773 BRCT sequence motif; other site 526227005774 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227005775 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227005776 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 526227005777 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 526227005778 ligand binding site [chemical binding]; other site 526227005779 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 526227005780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227005781 Walker A/P-loop; other site 526227005782 ATP binding site [chemical binding]; other site 526227005783 Q-loop/lid; other site 526227005784 ABC transporter signature motif; other site 526227005785 Walker B; other site 526227005786 D-loop; other site 526227005787 H-loop/switch region; other site 526227005788 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 526227005789 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 526227005790 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 526227005791 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 526227005792 Prephenate dehydratase; Region: PDT; pfam00800 526227005793 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 526227005794 putative L-Phe binding site [chemical binding]; other site 526227005795 Response regulator receiver domain; Region: Response_reg; pfam00072 526227005796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227005797 active site 526227005798 phosphorylation site [posttranslational modification] 526227005799 intermolecular recognition site; other site 526227005800 dimerization interface [polypeptide binding]; other site 526227005801 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 526227005802 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 526227005803 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 526227005804 OstA-like protein; Region: OstA; cl00844 526227005805 OstA-like protein; Region: OstA; cl00844 526227005806 OstA-like protein; Region: OstA; cl00844 526227005807 FOG: CBS domain [General function prediction only]; Region: COG0517 526227005808 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 526227005809 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 526227005810 NMT1/THI5 like; Region: NMT1; pfam09084 526227005811 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 526227005812 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 526227005813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227005814 dimer interface [polypeptide binding]; other site 526227005815 conserved gate region; other site 526227005816 putative PBP binding loops; other site 526227005817 ABC-ATPase subunit interface; other site 526227005818 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 526227005819 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 526227005820 NMT1/THI5 like; Region: NMT1; pfam09084 526227005821 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 526227005822 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 526227005823 cytosine deaminase; Provisional; Region: PRK09230 526227005824 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 526227005825 active site 526227005826 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 526227005827 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 526227005828 Walker A/P-loop; other site 526227005829 ATP binding site [chemical binding]; other site 526227005830 Q-loop/lid; other site 526227005831 ABC transporter signature motif; other site 526227005832 Walker B; other site 526227005833 D-loop; other site 526227005834 H-loop/switch region; other site 526227005835 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 526227005836 phenylhydantoinase; Validated; Region: PRK08323 526227005837 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 526227005838 tetramer interface [polypeptide binding]; other site 526227005839 active site 526227005840 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 526227005841 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 526227005842 homodimer interface [polypeptide binding]; other site 526227005843 active site 526227005844 FMN binding site [chemical binding]; other site 526227005845 substrate binding site [chemical binding]; other site 526227005846 4Fe-4S binding domain; Region: Fer4_6; pfam12837 526227005847 4Fe-4S binding domain; Region: Fer4; pfam00037 526227005848 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 526227005849 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526227005850 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526227005851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227005852 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 526227005853 Found in ATP-dependent protease La (LON); Region: LON; smart00464 526227005854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227005855 Walker A motif; other site 526227005856 ATP binding site [chemical binding]; other site 526227005857 Walker B motif; other site 526227005858 arginine finger; other site 526227005859 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 526227005860 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14334 526227005861 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 526227005862 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227005863 FeS/SAM binding site; other site 526227005864 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 526227005865 active site 526227005866 substrate binding site [chemical binding]; other site 526227005867 ATP binding site [chemical binding]; other site 526227005868 Protein of unknown function (DUF1679); Region: DUF1679; pfam07914 526227005869 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 526227005870 putative homodimer interface [polypeptide binding]; other site 526227005871 putative active site pocket [active] 526227005872 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 526227005873 Flagellin N-methylase; Region: FliB; pfam03692 526227005874 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 526227005875 MPN+ (JAMM) motif; other site 526227005876 Zinc-binding site [ion binding]; other site 526227005877 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 526227005878 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 526227005879 elongation factor G; Reviewed; Region: PRK12740 526227005880 G1 box; other site 526227005881 putative GEF interaction site [polypeptide binding]; other site 526227005882 GTP/Mg2+ binding site [chemical binding]; other site 526227005883 Switch I region; other site 526227005884 G2 box; other site 526227005885 G3 box; other site 526227005886 Switch II region; other site 526227005887 G4 box; other site 526227005888 G5 box; other site 526227005889 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 526227005890 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 526227005891 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 526227005892 von Willebrand factor type A domain; Region: VWA_2; pfam13519 526227005893 Protein of unknown function (DUF1999); Region: DUF1999; pfam09390 526227005894 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227005895 aconitate hydratase; Validated; Region: PRK09277 526227005896 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 526227005897 substrate binding site [chemical binding]; other site 526227005898 ligand binding site [chemical binding]; other site 526227005899 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 526227005900 substrate binding site [chemical binding]; other site 526227005901 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526227005902 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 526227005903 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526227005904 molybdopterin cofactor binding site; other site 526227005905 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 526227005906 molybdopterin cofactor binding site; other site 526227005907 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 526227005908 Protein of unknown function (DUF503); Region: DUF503; cl00669 526227005909 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 526227005910 FAD binding domain; Region: FAD_binding_4; pfam01565 526227005911 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 526227005912 EVE domain; Region: EVE; cl00728 526227005913 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 526227005914 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 526227005915 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 526227005916 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 526227005917 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 526227005918 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 526227005919 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 526227005920 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 526227005921 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 526227005922 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 526227005923 active site 526227005924 catalytic residues [active] 526227005925 metal binding site [ion binding]; metal-binding site 526227005926 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 526227005927 2-isopropylmalate synthase; Validated; Region: PRK00915 526227005928 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 526227005929 active site 526227005930 catalytic residues [active] 526227005931 metal binding site [ion binding]; metal-binding site 526227005932 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 526227005933 ketol-acid reductoisomerase; Provisional; Region: PRK05479 526227005934 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 526227005935 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 526227005936 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 526227005937 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 526227005938 putative valine binding site [chemical binding]; other site 526227005939 dimer interface [polypeptide binding]; other site 526227005940 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 526227005941 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 526227005942 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 526227005943 PYR/PP interface [polypeptide binding]; other site 526227005944 dimer interface [polypeptide binding]; other site 526227005945 TPP binding site [chemical binding]; other site 526227005946 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 526227005947 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 526227005948 TPP-binding site [chemical binding]; other site 526227005949 dimer interface [polypeptide binding]; other site 526227005950 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 526227005951 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 526227005952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 526227005953 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227005954 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 526227005955 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526227005956 MarR family; Region: MarR_2; pfam12802 526227005957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227005958 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227005959 putative substrate translocation pore; other site 526227005960 fumarate hydratase; Reviewed; Region: fumC; PRK00485 526227005961 Class II fumarases; Region: Fumarase_classII; cd01362 526227005962 active site 526227005963 tetramer interface [polypeptide binding]; other site 526227005964 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 526227005965 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 526227005966 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 526227005967 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 526227005968 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 526227005969 Predicted ATPase [General function prediction only]; Region: COG3899 526227005970 AAA ATPase domain; Region: AAA_16; pfam13191 526227005971 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227005972 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 526227005973 active site 526227005974 ribulose/triose binding site [chemical binding]; other site 526227005975 phosphate binding site [ion binding]; other site 526227005976 substrate (anthranilate) binding pocket [chemical binding]; other site 526227005977 product (indole) binding pocket [chemical binding]; other site 526227005978 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 526227005979 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 526227005980 active site 526227005981 nucleophile elbow; other site 526227005982 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 526227005983 DctM-like transporters; Region: DctM; pfam06808 526227005984 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 526227005985 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 526227005986 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227005987 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227005988 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 526227005989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227005990 S-adenosylmethionine binding site [chemical binding]; other site 526227005991 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 526227005992 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 526227005993 substrate binding site [chemical binding]; other site 526227005994 glutamase interaction surface [polypeptide binding]; other site 526227005995 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 526227005996 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 526227005997 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 526227005998 metal binding site [ion binding]; metal-binding site 526227005999 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 526227006000 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 526227006001 putative active site [active] 526227006002 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 526227006003 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 526227006004 Walker A/P-loop; other site 526227006005 ATP binding site [chemical binding]; other site 526227006006 Q-loop/lid; other site 526227006007 ABC transporter signature motif; other site 526227006008 Walker B; other site 526227006009 D-loop; other site 526227006010 H-loop/switch region; other site 526227006011 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 526227006012 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526227006013 ABC-ATPase subunit interface; other site 526227006014 dimer interface [polypeptide binding]; other site 526227006015 putative PBP binding regions; other site 526227006016 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 526227006017 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 526227006018 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 526227006019 putative hemin binding site; other site 526227006020 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 526227006021 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 526227006022 Protein of unknown function (DUF3234); Region: DUF3234; pfam11572 526227006023 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 526227006024 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 526227006025 glycyl-tRNA synthetase; Provisional; Region: PRK04173 526227006026 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 526227006027 motif 1; other site 526227006028 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 526227006029 dimer interface [polypeptide binding]; other site 526227006030 active site 526227006031 motif 2; other site 526227006032 motif 3; other site 526227006033 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 526227006034 anticodon binding site; other site 526227006035 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 526227006036 Clp amino terminal domain; Region: Clp_N; pfam02861 526227006037 Clp amino terminal domain; Region: Clp_N; pfam02861 526227006038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227006039 Walker A motif; other site 526227006040 ATP binding site [chemical binding]; other site 526227006041 Walker B motif; other site 526227006042 arginine finger; other site 526227006043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227006044 Walker A motif; other site 526227006045 ATP binding site [chemical binding]; other site 526227006046 Walker B motif; other site 526227006047 arginine finger; other site 526227006048 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 526227006049 DNA repair protein RadA; Provisional; Region: PRK11823 526227006050 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 526227006051 Walker A motif; other site 526227006052 ATP binding site [chemical binding]; other site 526227006053 Walker B motif; other site 526227006054 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 526227006055 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 526227006056 putative active site [active] 526227006057 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 526227006058 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 526227006059 CoA-ligase; Region: Ligase_CoA; pfam00549 526227006060 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 526227006061 CoA binding domain; Region: CoA_binding; smart00881 526227006062 CoA-ligase; Region: Ligase_CoA; pfam00549 526227006063 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 526227006064 active site 526227006065 catalytic residues [active] 526227006066 metal binding site [ion binding]; metal-binding site 526227006067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 526227006068 Protein of unknown function (DUF433); Region: DUF433; pfam04255 526227006069 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 526227006070 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 526227006071 GMP synthase; Reviewed; Region: guaA; PRK00074 526227006072 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 526227006073 AMP/PPi binding site [chemical binding]; other site 526227006074 candidate oxyanion hole; other site 526227006075 catalytic triad [active] 526227006076 potential glutamine specificity residues [chemical binding]; other site 526227006077 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 526227006078 ATP Binding subdomain [chemical binding]; other site 526227006079 Ligand Binding sites [chemical binding]; other site 526227006080 Dimerization subdomain; other site 526227006081 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 526227006082 Fe-S cluster binding site [ion binding]; other site 526227006083 active site 526227006084 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 526227006085 EamA-like transporter family; Region: EamA; pfam00892 526227006086 succinic semialdehyde dehydrogenase; Region: PLN02278 526227006087 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 526227006088 tetramerization interface [polypeptide binding]; other site 526227006089 NAD(P) binding site [chemical binding]; other site 526227006090 catalytic residues [active] 526227006091 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 526227006092 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 526227006093 purine monophosphate binding site [chemical binding]; other site 526227006094 dimer interface [polypeptide binding]; other site 526227006095 putative catalytic residues [active] 526227006096 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 526227006097 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 526227006098 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227006099 Yqey-like protein; Region: YqeY; cl17540 526227006100 Homeodomain-like domain; Region: HTH_23; cl17451 526227006101 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 526227006102 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 526227006103 putative transposase OrfB; Reviewed; Region: PHA02517 526227006104 Integrase core domain; Region: rve; pfam00665 526227006105 Integrase core domain; Region: rve_3; pfam13683 526227006106 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 526227006107 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 526227006108 Walker A/P-loop; other site 526227006109 ATP binding site [chemical binding]; other site 526227006110 Q-loop/lid; other site 526227006111 ABC transporter signature motif; other site 526227006112 Walker B; other site 526227006113 D-loop; other site 526227006114 H-loop/switch region; other site 526227006115 TOBE domain; Region: TOBE; pfam03459 526227006116 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 526227006117 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 526227006118 ATP-binding site [chemical binding]; other site 526227006119 Sugar specificity; other site 526227006120 Pyrimidine base specificity; other site 526227006121 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 526227006122 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 526227006123 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 526227006124 active site 526227006125 catalytic site [active] 526227006126 substrate binding site [chemical binding]; other site 526227006127 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 526227006128 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 526227006129 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 526227006130 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 526227006131 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 526227006132 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 526227006133 putative dimer interface [polypeptide binding]; other site 526227006134 thymidine kinase; Provisional; Region: PRK04296 526227006135 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 526227006136 Helix-turn-helix domain; Region: HTH_17; pfam12728 526227006137 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 526227006138 Beta-lactamase; Region: Beta-lactamase; pfam00144 526227006139 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526227006140 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526227006141 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 526227006142 intersubunit interface [polypeptide binding]; other site 526227006143 dephospho-CoA kinase; Region: TIGR00152 526227006144 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 526227006145 CoA-binding site [chemical binding]; other site 526227006146 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 526227006147 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 526227006148 active site 526227006149 NTP binding site [chemical binding]; other site 526227006150 metal binding triad [ion binding]; metal-binding site 526227006151 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 526227006152 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 526227006153 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 526227006154 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 526227006155 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 526227006156 ribonuclease R; Region: RNase_R; TIGR02063 526227006157 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 526227006158 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 526227006159 RNB domain; Region: RNB; pfam00773 526227006160 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 526227006161 RNA binding site [nucleotide binding]; other site 526227006162 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 526227006163 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227006164 inhibitor-cofactor binding pocket; inhibition site 526227006165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227006166 catalytic residue [active] 526227006167 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 526227006168 active site 526227006169 Ribosome-binding factor A; Region: RBFA; pfam02033 526227006170 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14323 526227006171 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 526227006172 active site 526227006173 substrate binding site [chemical binding]; other site 526227006174 metal binding site [ion binding]; metal-binding site 526227006175 DNA polymerase I; Provisional; Region: PRK05755 526227006176 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 526227006177 active site 526227006178 metal binding site 1 [ion binding]; metal-binding site 526227006179 putative 5' ssDNA interaction site; other site 526227006180 metal binding site 3; metal-binding site 526227006181 metal binding site 2 [ion binding]; metal-binding site 526227006182 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 526227006183 putative DNA binding site [nucleotide binding]; other site 526227006184 putative metal binding site [ion binding]; other site 526227006185 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 526227006186 active site 526227006187 catalytic site [active] 526227006188 substrate binding site [chemical binding]; other site 526227006189 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 526227006190 active site 526227006191 DNA binding site [nucleotide binding] 526227006192 catalytic site [active] 526227006193 Uncharacterized conserved protein [Function unknown]; Region: COG1739 526227006194 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 526227006195 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 526227006196 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 526227006197 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 526227006198 shikimate binding site; other site 526227006199 NAD(P) binding site [chemical binding]; other site 526227006200 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 526227006201 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 526227006202 dimer interface [polypeptide binding]; other site 526227006203 active site residues [active] 526227006204 hypothetical protein; Provisional; Region: PRK13665 526227006205 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 526227006206 PhoH-like protein; Region: PhoH; pfam02562 526227006207 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 526227006208 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 526227006209 Domain of unknown function DUF21; Region: DUF21; pfam01595 526227006210 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 526227006211 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 526227006212 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 526227006213 Transporter associated domain; Region: CorC_HlyC; smart01091 526227006214 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 526227006215 active site 526227006216 catalytic motif [active] 526227006217 Zn binding site [ion binding]; other site 526227006218 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 526227006219 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 526227006220 inhibitor site; inhibition site 526227006221 active site 526227006222 dimer interface [polypeptide binding]; other site 526227006223 catalytic residue [active] 526227006224 Filamin/ABP280 repeat; Region: Filamin; pfam00630 526227006225 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 526227006226 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 526227006227 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 526227006228 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 526227006229 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 526227006230 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 526227006231 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 526227006232 dimer interface [polypeptide binding]; other site 526227006233 putative anticodon binding site; other site 526227006234 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 526227006235 motif 1; other site 526227006236 active site 526227006237 motif 2; other site 526227006238 motif 3; other site 526227006239 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 526227006240 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 526227006241 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 526227006242 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526227006243 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 526227006244 Outer membrane efflux protein; Region: OEP; pfam02321 526227006245 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 526227006246 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 526227006247 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 526227006248 HlyD family secretion protein; Region: HlyD_3; pfam13437 526227006249 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 526227006250 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 526227006251 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 526227006252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227006253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227006254 putative substrate translocation pore; other site 526227006255 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 526227006256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227006257 ATP binding site [chemical binding]; other site 526227006258 putative Mg++ binding site [ion binding]; other site 526227006259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227006260 nucleotide binding region [chemical binding]; other site 526227006261 ATP-binding site [chemical binding]; other site 526227006262 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 526227006263 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 526227006264 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 526227006265 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 526227006266 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 526227006267 GTP/Mg2+ binding site [chemical binding]; other site 526227006268 G5 box; other site 526227006269 trmE is a tRNA modification GTPase; Region: trmE; cd04164 526227006270 G1 box; other site 526227006271 G1 box; other site 526227006272 GTP/Mg2+ binding site [chemical binding]; other site 526227006273 Switch I region; other site 526227006274 Switch I region; other site 526227006275 G2 box; other site 526227006276 G2 box; other site 526227006277 Switch II region; other site 526227006278 G3 box; other site 526227006279 G4 box; other site 526227006280 G5 box; other site 526227006281 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 526227006282 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 526227006283 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 526227006284 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 526227006285 TrkA-N domain; Region: TrkA_N; pfam02254 526227006286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 526227006287 Family of unknown function (DUF490); Region: DUF490; pfam04357 526227006288 acylphosphatase; Provisional; Region: PRK14433 526227006289 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 526227006290 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 526227006291 HflX GTPase family; Region: HflX; cd01878 526227006292 G1 box; other site 526227006293 GTP/Mg2+ binding site [chemical binding]; other site 526227006294 Switch I region; other site 526227006295 G2 box; other site 526227006296 G3 box; other site 526227006297 Switch II region; other site 526227006298 G4 box; other site 526227006299 G5 box; other site 526227006300 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 526227006301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227006302 active site 526227006303 motif I; other site 526227006304 motif II; other site 526227006305 Uncharacterized conserved protein [Function unknown]; Region: COG1434 526227006306 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 526227006307 putative active site [active] 526227006308 DivIVA protein; Region: DivIVA; pfam05103 526227006309 DivIVA domain; Region: DivI1A_domain; TIGR03544 526227006310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 526227006311 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 526227006312 catalytic residue [active] 526227006313 purine nucleoside phosphorylase; Provisional; Region: PRK08202 526227006314 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 526227006315 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 526227006316 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 526227006317 Surface antigen; Region: Bac_surface_Ag; pfam01103 526227006318 cyclase homology domain; Region: CHD; cd07302 526227006319 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 526227006320 nucleotidyl binding site; other site 526227006321 metal binding site [ion binding]; metal-binding site 526227006322 dimer interface [polypeptide binding]; other site 526227006323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227006324 Walker A motif; other site 526227006325 ATP binding site [chemical binding]; other site 526227006326 Immunoglobulin domain; Region: Ig; cl11960 526227006327 CHC2 zinc finger; Region: zf-CHC2; pfam01807 526227006328 DNA primase, catalytic core; Region: dnaG; TIGR01391 526227006329 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 526227006330 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 526227006331 active site 526227006332 metal binding site [ion binding]; metal-binding site 526227006333 interdomain interaction site; other site 526227006334 Predicted transcriptional regulator [Transcription]; Region: COG1959 526227006335 Transcriptional regulator; Region: Rrf2; pfam02082 526227006336 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 526227006337 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 526227006338 active site residue [active] 526227006339 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 526227006340 active site residue [active] 526227006341 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227006342 active site residue [active] 526227006343 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 526227006344 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526227006345 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526227006346 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 526227006347 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526227006348 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526227006349 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 526227006350 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 526227006351 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13829 526227006352 RimM N-terminal domain; Region: RimM; pfam01782 526227006353 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 526227006354 KH domain; Region: KH_4; pfam13083 526227006355 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 526227006356 signal recognition particle protein; Provisional; Region: PRK10867 526227006357 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 526227006358 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 526227006359 P loop; other site 526227006360 GTP binding site [chemical binding]; other site 526227006361 Signal peptide binding domain; Region: SRP_SPB; pfam02978 526227006362 Domain of unknown function (DUF305); Region: DUF305; cl17794 526227006363 Domain of unknown function (DUF305); Region: DUF305; cl17794 526227006364 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 526227006365 MgtE intracellular N domain; Region: MgtE_N; pfam03448 526227006366 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 526227006367 Divalent cation transporter; Region: MgtE; pfam01769 526227006368 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 526227006369 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227006370 agmatinase; Region: agmatinase; TIGR01230 526227006371 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 526227006372 active site 526227006373 metal binding site [ion binding]; metal-binding site 526227006374 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 526227006375 Phosphotransferase enzyme family; Region: APH; pfam01636 526227006376 putative active site [active] 526227006377 putative substrate binding site [chemical binding]; other site 526227006378 ATP binding site [chemical binding]; other site 526227006379 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 526227006380 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227006381 active site 526227006382 Nuclease-related domain; Region: NERD; pfam08378 526227006383 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 526227006384 Glycoprotease family; Region: Peptidase_M22; pfam00814 526227006385 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 526227006386 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 526227006387 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526227006388 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 526227006389 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526227006390 DNA binding residues [nucleotide binding] 526227006391 MOSC domain; Region: MOSC; pfam03473 526227006392 Fe-S metabolism associated domain; Region: SufE; cl00951 526227006393 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526227006394 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526227006395 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526227006396 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227006397 MULE transposase domain; Region: MULE; pfam10551 526227006398 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526227006399 putative transposase OrfB; Reviewed; Region: PHA02517 526227006400 Integrase core domain; Region: rve; pfam00665 526227006401 Integrase core domain; Region: rve_3; pfam13683 526227006402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526227006403 dimerization interface [polypeptide binding]; other site 526227006404 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 526227006405 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227006406 Zn2+ binding site [ion binding]; other site 526227006407 Mg2+ binding site [ion binding]; other site 526227006408 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526227006409 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 526227006410 dihydrodipicolinate synthase; Region: dapA; TIGR00674 526227006411 dimer interface [polypeptide binding]; other site 526227006412 active site 526227006413 catalytic residue [active] 526227006414 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 526227006415 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 526227006416 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 526227006417 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 526227006418 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 526227006419 NAD binding site [chemical binding]; other site 526227006420 catalytic residues [active] 526227006421 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 526227006422 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 526227006423 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 526227006424 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 526227006425 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526227006426 active site 526227006427 metal binding site [ion binding]; metal-binding site 526227006428 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 526227006429 tetramer interface [polypeptide binding]; other site 526227006430 active site 526227006431 metal binding site [ion binding]; metal-binding site 526227006432 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 526227006433 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 526227006434 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526227006435 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526227006436 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 526227006437 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 526227006438 putative ligand binding site [chemical binding]; other site 526227006439 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227006440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227006441 TM-ABC transporter signature motif; other site 526227006442 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 526227006443 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227006444 TM-ABC transporter signature motif; other site 526227006445 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227006446 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 526227006447 Walker A/P-loop; other site 526227006448 ATP binding site [chemical binding]; other site 526227006449 Q-loop/lid; other site 526227006450 ABC transporter signature motif; other site 526227006451 Walker B; other site 526227006452 D-loop; other site 526227006453 H-loop/switch region; other site 526227006454 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227006455 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 526227006456 Walker A/P-loop; other site 526227006457 ATP binding site [chemical binding]; other site 526227006458 Q-loop/lid; other site 526227006459 ABC transporter signature motif; other site 526227006460 Walker B; other site 526227006461 D-loop; other site 526227006462 H-loop/switch region; other site 526227006463 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526227006464 CoenzymeA binding site [chemical binding]; other site 526227006465 subunit interaction site [polypeptide binding]; other site 526227006466 PHB binding site; other site 526227006467 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 526227006468 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526227006469 dimer interface [polypeptide binding]; other site 526227006470 active site 526227006471 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526227006472 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 526227006473 acyl-activating enzyme (AAE) consensus motif; other site 526227006474 AMP binding site [chemical binding]; other site 526227006475 active site 526227006476 CoA binding site [chemical binding]; other site 526227006477 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 526227006478 active site 2 [active] 526227006479 active site 1 [active] 526227006480 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 526227006481 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 526227006482 hypothetical protein; Validated; Region: PRK06840 526227006483 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 526227006484 active site 526227006485 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 526227006486 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526227006487 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 526227006488 acyl-activating enzyme (AAE) consensus motif; other site 526227006489 acyl-activating enzyme (AAE) consensus motif; other site 526227006490 putative AMP binding site [chemical binding]; other site 526227006491 putative active site [active] 526227006492 putative CoA binding site [chemical binding]; other site 526227006493 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526227006494 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 526227006495 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 526227006496 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 526227006497 dimer interaction site [polypeptide binding]; other site 526227006498 substrate-binding tunnel; other site 526227006499 active site 526227006500 catalytic site [active] 526227006501 substrate binding site [chemical binding]; other site 526227006502 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 526227006503 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227006504 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227006505 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227006506 TM-ABC transporter signature motif; other site 526227006507 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227006508 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 526227006509 TM-ABC transporter signature motif; other site 526227006510 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227006511 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 526227006512 Walker A/P-loop; other site 526227006513 ATP binding site [chemical binding]; other site 526227006514 Q-loop/lid; other site 526227006515 ABC transporter signature motif; other site 526227006516 Walker B; other site 526227006517 D-loop; other site 526227006518 H-loop/switch region; other site 526227006519 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227006520 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 526227006521 Walker A/P-loop; other site 526227006522 ATP binding site [chemical binding]; other site 526227006523 Q-loop/lid; other site 526227006524 ABC transporter signature motif; other site 526227006525 Walker B; other site 526227006526 D-loop; other site 526227006527 H-loop/switch region; other site 526227006528 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 526227006529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227006530 NAD(P) binding site [chemical binding]; other site 526227006531 active site 526227006532 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 526227006533 Glucose inhibited division protein A; Region: GIDA; pfam01134 526227006534 Predicted small integral membrane protein [Function unknown]; Region: COG5605 526227006535 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 526227006536 Subunit I/III interface [polypeptide binding]; other site 526227006537 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 526227006538 Subunit I/III interface [polypeptide binding]; other site 526227006539 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 526227006540 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 526227006541 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 526227006542 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 526227006543 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 526227006544 hydrophobic ligand binding site; other site 526227006545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227006546 active site 526227006547 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227006548 active site 526227006549 Bifunctional nuclease; Region: DNase-RNase; pfam02577 526227006550 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227006551 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227006552 active site 526227006553 metal binding site [ion binding]; metal-binding site 526227006554 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 526227006555 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 526227006556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526227006557 FeS/SAM binding site; other site 526227006558 serine racemase; Region: PLN02970 526227006559 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 526227006560 tetramer interface [polypeptide binding]; other site 526227006561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227006562 catalytic residue [active] 526227006563 Protein of unknown function (DUF664); Region: DUF664; pfam04978 526227006564 DinB superfamily; Region: DinB_2; pfam12867 526227006565 Predicted membrane protein [Function unknown]; Region: COG2311 526227006566 Protein of unknown function (DUF418); Region: DUF418; pfam04235 526227006567 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 526227006568 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 526227006569 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 526227006570 catalytic site [active] 526227006571 subunit interface [polypeptide binding]; other site 526227006572 Nuclease-related domain; Region: NERD; pfam08378 526227006573 acetyltransferase; Provisional; Region: PRK07757 526227006574 Coenzyme A binding pocket [chemical binding]; other site 526227006575 argininosuccinate lyase; Provisional; Region: PRK00855 526227006576 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 526227006577 active sites [active] 526227006578 tetramer interface [polypeptide binding]; other site 526227006579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227006580 Coenzyme A binding pocket [chemical binding]; other site 526227006581 argininosuccinate synthase; Provisional; Region: PRK13820 526227006582 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 526227006583 ANP binding site [chemical binding]; other site 526227006584 Substrate Binding Site II [chemical binding]; other site 526227006585 Substrate Binding Site I [chemical binding]; other site 526227006586 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227006587 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227006588 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227006589 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227006590 metal binding site [ion binding]; metal-binding site 526227006591 active site 526227006592 I-site; other site 526227006593 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 526227006594 histidinol dehydrogenase; Region: hisD; TIGR00069 526227006595 NAD binding site [chemical binding]; other site 526227006596 dimerization interface [polypeptide binding]; other site 526227006597 product binding site; other site 526227006598 substrate binding site [chemical binding]; other site 526227006599 zinc binding site [ion binding]; other site 526227006600 catalytic residues [active] 526227006601 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 526227006602 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 526227006603 GTP-binding protein LepA; Provisional; Region: PRK05433 526227006604 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 526227006605 G1 box; other site 526227006606 putative GEF interaction site [polypeptide binding]; other site 526227006607 GTP/Mg2+ binding site [chemical binding]; other site 526227006608 Switch I region; other site 526227006609 G2 box; other site 526227006610 G3 box; other site 526227006611 Switch II region; other site 526227006612 G4 box; other site 526227006613 G5 box; other site 526227006614 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 526227006615 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 526227006616 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 526227006617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227006618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227006619 dimer interface [polypeptide binding]; other site 526227006620 phosphorylation site [posttranslational modification] 526227006621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227006622 ATP binding site [chemical binding]; other site 526227006623 Mg2+ binding site [ion binding]; other site 526227006624 G-X-G motif; other site 526227006625 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227006626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227006627 active site 526227006628 phosphorylation site [posttranslational modification] 526227006629 intermolecular recognition site; other site 526227006630 dimerization interface [polypeptide binding]; other site 526227006631 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227006632 DNA binding residues [nucleotide binding] 526227006633 dimerization interface [polypeptide binding]; other site 526227006634 Protein of unknown function (DUF970); Region: DUF970; pfam06153 526227006635 Thioredoxin; Region: Thioredoxin_4; pfam13462 526227006636 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 526227006637 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 526227006638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227006639 S-adenosylmethionine binding site [chemical binding]; other site 526227006640 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 526227006641 Domain of unknown function (DUF814); Region: DUF814; pfam05670 526227006642 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227006643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006644 dimer interface [polypeptide binding]; other site 526227006645 conserved gate region; other site 526227006646 putative PBP binding loops; other site 526227006647 ABC-ATPase subunit interface; other site 526227006648 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 526227006649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006650 putative PBP binding loops; other site 526227006651 ABC-ATPase subunit interface; other site 526227006652 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227006653 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227006654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227006655 putative DNA binding site [nucleotide binding]; other site 526227006656 putative Zn2+ binding site [ion binding]; other site 526227006657 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 526227006658 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 526227006659 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 526227006660 dimerization interface [polypeptide binding]; other site 526227006661 putative tRNAtyr binding site [nucleotide binding]; other site 526227006662 putative active site [active] 526227006663 EDD domain protein, DegV family; Region: DegV; TIGR00762 526227006664 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 526227006665 EDD domain protein, DegV family; Region: DegV; TIGR00762 526227006666 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 526227006667 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 526227006668 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 526227006669 ligand binding site [chemical binding]; other site 526227006670 NAD binding site [chemical binding]; other site 526227006671 dimerization interface [polypeptide binding]; other site 526227006672 catalytic site [active] 526227006673 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 526227006674 putative L-serine binding site [chemical binding]; other site 526227006675 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 526227006676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227006677 catalytic residue [active] 526227006678 putative 4-hydroxybenzoate polyprenyltransferase; Region: ubiA_other; TIGR01475 526227006679 UbiA prenyltransferase family; Region: UbiA; pfam01040 526227006680 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 526227006681 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 526227006682 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 526227006683 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227006684 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227006685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006686 dimer interface [polypeptide binding]; other site 526227006687 conserved gate region; other site 526227006688 putative PBP binding loops; other site 526227006689 ABC-ATPase subunit interface; other site 526227006690 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227006691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006692 dimer interface [polypeptide binding]; other site 526227006693 conserved gate region; other site 526227006694 putative PBP binding loops; other site 526227006695 ABC-ATPase subunit interface; other site 526227006696 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 526227006697 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 526227006698 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 526227006699 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 526227006700 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 526227006701 nucleotide binding site/active site [active] 526227006702 HIT family signature motif; other site 526227006703 catalytic residue [active] 526227006704 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 526227006705 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 526227006706 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 526227006707 active site 526227006708 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 526227006709 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 526227006710 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 526227006711 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 526227006712 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 526227006713 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 526227006714 dimerization interface [polypeptide binding]; other site 526227006715 domain crossover interface; other site 526227006716 redox-dependent activation switch; other site 526227006717 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 526227006718 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227006719 inhibitor-cofactor binding pocket; inhibition site 526227006720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227006721 catalytic residue [active] 526227006722 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227006723 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 526227006724 Walker A/P-loop; other site 526227006725 ATP binding site [chemical binding]; other site 526227006726 Q-loop/lid; other site 526227006727 ABC transporter signature motif; other site 526227006728 Walker B; other site 526227006729 D-loop; other site 526227006730 H-loop/switch region; other site 526227006731 TOBE domain; Region: TOBE_2; pfam08402 526227006732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006733 dimer interface [polypeptide binding]; other site 526227006734 conserved gate region; other site 526227006735 putative PBP binding loops; other site 526227006736 ABC-ATPase subunit interface; other site 526227006737 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 526227006738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006739 dimer interface [polypeptide binding]; other site 526227006740 conserved gate region; other site 526227006741 putative PBP binding loops; other site 526227006742 ABC-ATPase subunit interface; other site 526227006743 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 526227006744 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526227006745 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 526227006746 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227006747 inhibitor-cofactor binding pocket; inhibition site 526227006748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227006749 catalytic residue [active] 526227006750 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 526227006751 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 526227006752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227006753 Coenzyme A binding pocket [chemical binding]; other site 526227006754 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 526227006755 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 526227006756 active site 526227006757 putative acetyltransferase; Provisional; Region: PRK03624 526227006758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227006759 Coenzyme A binding pocket [chemical binding]; other site 526227006760 aminotransferase; Validated; Region: PRK07046 526227006761 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526227006762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227006763 catalytic residue [active] 526227006764 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227006765 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 526227006766 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 526227006767 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 526227006768 tetrameric interface [polypeptide binding]; other site 526227006769 NAD binding site [chemical binding]; other site 526227006770 catalytic residues [active] 526227006771 substrate binding site [chemical binding]; other site 526227006772 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 526227006773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006774 dimer interface [polypeptide binding]; other site 526227006775 conserved gate region; other site 526227006776 putative PBP binding loops; other site 526227006777 ABC-ATPase subunit interface; other site 526227006778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006779 putative PBP binding loops; other site 526227006780 dimer interface [polypeptide binding]; other site 526227006781 ABC-ATPase subunit interface; other site 526227006782 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227006783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227006784 Walker A/P-loop; other site 526227006785 ATP binding site [chemical binding]; other site 526227006786 Q-loop/lid; other site 526227006787 ABC transporter signature motif; other site 526227006788 Walker B; other site 526227006789 D-loop; other site 526227006790 H-loop/switch region; other site 526227006791 TOBE domain; Region: TOBE_2; pfam08402 526227006792 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227006793 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 526227006794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 526227006795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 526227006796 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 526227006797 putative substrate binding pocket [chemical binding]; other site 526227006798 dimerization interface [polypeptide binding]; other site 526227006799 Protein of unknown function (DUF3197); Region: DUF3197; pfam11432 526227006800 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 526227006801 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 526227006802 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 526227006803 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 526227006804 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 526227006805 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526227006806 active site 526227006807 metal binding site [ion binding]; metal-binding site 526227006808 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526227006809 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 526227006810 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 526227006811 4Fe-4S binding domain; Region: Fer4; cl02805 526227006812 Cysteine-rich domain; Region: CCG; pfam02754 526227006813 Cysteine-rich domain; Region: CCG; pfam02754 526227006814 Bacterial transcriptional activator domain; Region: BTAD; smart01043 526227006815 AAA ATPase domain; Region: AAA_16; pfam13191 526227006816 AAA domain; Region: AAA_22; pfam13401 526227006817 putative transposase OrfB; Reviewed; Region: PHA02517 526227006818 Integrase core domain; Region: rve; pfam00665 526227006819 Integrase core domain; Region: rve_3; pfam13683 526227006820 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 526227006821 DinB superfamily; Region: DinB_2; pfam12867 526227006822 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526227006823 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 526227006824 Divergent PAP2 family; Region: DUF212; pfam02681 526227006825 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14173 526227006826 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 526227006827 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 526227006828 homodimer interface [polypeptide binding]; other site 526227006829 NADP binding site [chemical binding]; other site 526227006830 substrate binding site [chemical binding]; other site 526227006831 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 526227006832 putative RNA binding site [nucleotide binding]; other site 526227006833 Asp23 family; Region: Asp23; pfam03780 526227006834 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 526227006835 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227006836 TM-ABC transporter signature motif; other site 526227006837 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 526227006838 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 526227006839 acyl-activating enzyme (AAE) consensus motif; other site 526227006840 putative AMP binding site [chemical binding]; other site 526227006841 putative active site [active] 526227006842 putative CoA binding site [chemical binding]; other site 526227006843 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227006844 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 526227006845 Walker A/P-loop; other site 526227006846 ATP binding site [chemical binding]; other site 526227006847 Q-loop/lid; other site 526227006848 ABC transporter signature motif; other site 526227006849 Walker B; other site 526227006850 D-loop; other site 526227006851 H-loop/switch region; other site 526227006852 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227006853 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 526227006854 Walker A/P-loop; other site 526227006855 ATP binding site [chemical binding]; other site 526227006856 Q-loop/lid; other site 526227006857 ABC transporter signature motif; other site 526227006858 Walker B; other site 526227006859 D-loop; other site 526227006860 H-loop/switch region; other site 526227006861 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 526227006862 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227006863 TM-ABC transporter signature motif; other site 526227006864 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 526227006865 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227006866 Methyltransferase domain; Region: Methyltransf_18; pfam12847 526227006867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 526227006868 binding surface 526227006869 TPR motif; other site 526227006870 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 526227006871 deoxyhypusine synthase; Region: dhys; TIGR00321 526227006872 Deoxyhypusine synthase; Region: DS; cl00826 526227006873 putative transposase OrfB; Reviewed; Region: PHA02517 526227006874 Integrase core domain; Region: rve; pfam00665 526227006875 Integrase core domain; Region: rve_3; pfam13683 526227006876 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227006877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227006878 putative substrate translocation pore; other site 526227006879 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 526227006880 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 526227006881 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 526227006882 active site 526227006883 HIGH motif; other site 526227006884 KMSK motif region; other site 526227006885 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 526227006886 tRNA binding surface [nucleotide binding]; other site 526227006887 anticodon binding site; other site 526227006888 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 526227006889 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526227006890 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 526227006891 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 526227006892 Substrate-binding site [chemical binding]; other site 526227006893 Substrate specificity [chemical binding]; other site 526227006894 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 526227006895 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 526227006896 Substrate-binding site [chemical binding]; other site 526227006897 Substrate specificity [chemical binding]; other site 526227006898 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 526227006899 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 526227006900 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 526227006901 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 526227006902 putative active site; other site 526227006903 catalytic triad [active] 526227006904 putative dimer interface [polypeptide binding]; other site 526227006905 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 526227006906 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227006907 active site 526227006908 catalytic residues [active] 526227006909 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 526227006910 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526227006911 GAF domain; Region: GAF; pfam01590 526227006912 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227006913 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227006914 metal binding site [ion binding]; metal-binding site 526227006915 active site 526227006916 I-site; other site 526227006917 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 526227006918 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 526227006919 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526227006920 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526227006921 Uncharacterized conserved protein [Function unknown]; Region: COG0327 526227006922 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 526227006923 thymidylate kinase; Validated; Region: tmk; PRK00698 526227006924 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 526227006925 TMP-binding site; other site 526227006926 ATP-binding site [chemical binding]; other site 526227006927 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 526227006928 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 526227006929 tetramer interface [polypeptide binding]; other site 526227006930 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227006931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006932 dimer interface [polypeptide binding]; other site 526227006933 conserved gate region; other site 526227006934 putative PBP binding loops; other site 526227006935 ABC-ATPase subunit interface; other site 526227006936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227006937 dimer interface [polypeptide binding]; other site 526227006938 conserved gate region; other site 526227006939 putative PBP binding loops; other site 526227006940 ABC-ATPase subunit interface; other site 526227006941 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227006942 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227006943 HflC protein; Region: hflC; TIGR01932 526227006944 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 526227006945 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 526227006946 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 526227006947 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 526227006948 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526227006949 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526227006950 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227006951 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 526227006952 Dehydroquinase class II; Region: DHquinase_II; pfam01220 526227006953 trimer interface [polypeptide binding]; other site 526227006954 active site 526227006955 dimer interface [polypeptide binding]; other site 526227006956 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 526227006957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 526227006958 DNA gyrase subunit A; Validated; Region: PRK05560 526227006959 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 526227006960 CAP-like domain; other site 526227006961 active site 526227006962 primary dimer interface [polypeptide binding]; other site 526227006963 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526227006964 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526227006965 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526227006966 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526227006967 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526227006968 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 526227006969 NAD(P) binding site [chemical binding]; other site 526227006970 short chain dehydrogenase; Provisional; Region: PRK07677 526227006971 substrate binding site [chemical binding]; other site 526227006972 homotetramer interface [polypeptide binding]; other site 526227006973 active site 526227006974 homodimer interface [polypeptide binding]; other site 526227006975 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 526227006976 PKD domain; Region: PKD; pfam00801 526227006977 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 526227006978 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 526227006979 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 526227006980 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 526227006981 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 526227006982 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 526227006983 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 526227006984 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 526227006985 putative active site [active] 526227006986 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 526227006987 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 526227006988 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 526227006989 oligomer interface [polypeptide binding]; other site 526227006990 metal binding site [ion binding]; metal-binding site 526227006991 metal binding site [ion binding]; metal-binding site 526227006992 putative Cl binding site [ion binding]; other site 526227006993 aspartate ring; other site 526227006994 basic sphincter; other site 526227006995 hydrophobic gate; other site 526227006996 periplasmic entrance; other site 526227006997 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 526227006998 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227006999 ligand binding site [chemical binding]; other site 526227007000 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 526227007001 putative switch regulator; other site 526227007002 non-specific DNA interactions [nucleotide binding]; other site 526227007003 DNA binding site [nucleotide binding] 526227007004 sequence specific DNA binding site [nucleotide binding]; other site 526227007005 putative cAMP binding site [chemical binding]; other site 526227007006 putative transposase OrfB; Reviewed; Region: PHA02517 526227007007 Integrase core domain; Region: rve; pfam00665 526227007008 Integrase core domain; Region: rve_3; pfam13683 526227007009 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 526227007010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526227007011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227007012 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 526227007013 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 526227007014 active site 526227007015 metal binding site [ion binding]; metal-binding site 526227007016 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 526227007017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227007018 Probable transposase; Region: OrfB_IS605; pfam01385 526227007019 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227007020 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 526227007021 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 526227007022 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 526227007023 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 526227007024 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 526227007025 putative transposase OrfB; Reviewed; Region: PHA02517 526227007026 Integrase core domain; Region: rve; pfam00665 526227007027 Integrase core domain; Region: rve_3; pfam13683 526227007028 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 526227007029 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 526227007030 dimerization interface [polypeptide binding]; other site 526227007031 ligand binding site [chemical binding]; other site 526227007032 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227007033 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227007034 TM-ABC transporter signature motif; other site 526227007035 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 526227007036 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227007037 TM-ABC transporter signature motif; other site 526227007038 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227007039 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 526227007040 Walker A/P-loop; other site 526227007041 ATP binding site [chemical binding]; other site 526227007042 Q-loop/lid; other site 526227007043 ABC transporter signature motif; other site 526227007044 Walker B; other site 526227007045 D-loop; other site 526227007046 H-loop/switch region; other site 526227007047 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227007048 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 526227007049 Walker A/P-loop; other site 526227007050 ATP binding site [chemical binding]; other site 526227007051 Q-loop/lid; other site 526227007052 ABC transporter signature motif; other site 526227007053 Walker B; other site 526227007054 D-loop; other site 526227007055 H-loop/switch region; other site 526227007056 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227007057 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 526227007058 peptide binding site [polypeptide binding]; other site 526227007059 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227007060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007061 dimer interface [polypeptide binding]; other site 526227007062 conserved gate region; other site 526227007063 putative PBP binding loops; other site 526227007064 ABC-ATPase subunit interface; other site 526227007065 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 526227007066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007067 dimer interface [polypeptide binding]; other site 526227007068 conserved gate region; other site 526227007069 putative PBP binding loops; other site 526227007070 ABC-ATPase subunit interface; other site 526227007071 PrcB C-terminal; Region: PrcB_C; pfam14343 526227007072 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 526227007073 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526227007074 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 526227007075 MPT binding site; other site 526227007076 trimer interface [polypeptide binding]; other site 526227007077 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 526227007078 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 526227007079 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 526227007080 Walker A/P-loop; other site 526227007081 ATP binding site [chemical binding]; other site 526227007082 Q-loop/lid; other site 526227007083 ABC transporter signature motif; other site 526227007084 Walker B; other site 526227007085 D-loop; other site 526227007086 H-loop/switch region; other site 526227007087 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 526227007088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 526227007089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227007090 Walker A/P-loop; other site 526227007091 ATP binding site [chemical binding]; other site 526227007092 Q-loop/lid; other site 526227007093 ABC transporter signature motif; other site 526227007094 Walker B; other site 526227007095 D-loop; other site 526227007096 H-loop/switch region; other site 526227007097 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 526227007098 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 526227007099 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 526227007100 metal binding site [ion binding]; metal-binding site 526227007101 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227007102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227007103 active site 526227007104 phosphorylation site [posttranslational modification] 526227007105 intermolecular recognition site; other site 526227007106 dimerization interface [polypeptide binding]; other site 526227007107 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227007108 DNA binding residues [nucleotide binding] 526227007109 dimerization interface [polypeptide binding]; other site 526227007110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227007111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526227007112 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 526227007113 Phosphotransferase enzyme family; Region: APH; pfam01636 526227007114 active site 526227007115 substrate binding site [chemical binding]; other site 526227007116 ATP binding site [chemical binding]; other site 526227007117 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 526227007118 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227007119 active site 526227007120 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 526227007121 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 526227007122 Mg++ binding site [ion binding]; other site 526227007123 putative catalytic motif [active] 526227007124 substrate binding site [chemical binding]; other site 526227007125 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 526227007126 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 526227007127 active site 526227007128 homodimer interface [polypeptide binding]; other site 526227007129 H+ Antiporter protein; Region: 2A0121; TIGR00900 526227007130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227007131 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 526227007132 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 526227007133 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 526227007134 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526227007135 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526227007136 active site 526227007137 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 526227007138 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 526227007139 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 526227007140 metal-dependent hydrolase; Provisional; Region: PRK13291 526227007141 DinB superfamily; Region: DinB_2; pfam12867 526227007142 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526227007143 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 526227007144 NAD(P) binding site [chemical binding]; other site 526227007145 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526227007146 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 526227007147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007148 dimer interface [polypeptide binding]; other site 526227007149 conserved gate region; other site 526227007150 putative PBP binding loops; other site 526227007151 ABC-ATPase subunit interface; other site 526227007152 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227007153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007154 putative PBP binding loops; other site 526227007155 dimer interface [polypeptide binding]; other site 526227007156 ABC-ATPase subunit interface; other site 526227007157 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227007158 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 526227007159 Chromate transporter; Region: Chromate_transp; pfam02417 526227007160 Chromate transporter; Region: Chromate_transp; pfam02417 526227007161 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 526227007162 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227007163 active site 526227007164 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 526227007165 Peptidase family M50; Region: Peptidase_M50; pfam02163 526227007166 active site 526227007167 putative substrate binding region [chemical binding]; other site 526227007168 FOG: CBS domain [General function prediction only]; Region: COG0517 526227007169 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 526227007170 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 526227007171 glyoxylate reductase; Reviewed; Region: PRK13243 526227007172 dimerization interface [polypeptide binding]; other site 526227007173 ligand binding site [chemical binding]; other site 526227007174 NADP binding site [chemical binding]; other site 526227007175 catalytic site [active] 526227007176 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 526227007177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227007178 binding surface 526227007179 TPR motif; other site 526227007180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227007181 binding surface 526227007182 TPR motif; other site 526227007183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227007184 binding surface 526227007185 TPR motif; other site 526227007186 TPR repeat; Region: TPR_11; pfam13414 526227007187 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 526227007188 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 526227007189 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 526227007190 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 526227007191 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 526227007192 active site 526227007193 RNA/DNA hybrid binding site [nucleotide binding]; other site 526227007194 Predicted transcriptional regulator [Transcription]; Region: COG2345 526227007195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227007196 putative DNA binding site [nucleotide binding]; other site 526227007197 putative Zn2+ binding site [ion binding]; other site 526227007198 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 526227007199 antiporter inner membrane protein; Provisional; Region: PRK11670 526227007200 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 526227007201 Walker A motif; other site 526227007202 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 526227007203 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 526227007204 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 526227007205 hydrophobic ligand binding site; other site 526227007206 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526227007207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227007208 TPR motif; other site 526227007209 binding surface 526227007210 TPR repeat; Region: TPR_11; pfam13414 526227007211 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227007212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227007213 binding surface 526227007214 TPR motif; other site 526227007215 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227007216 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227007217 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 526227007218 nudix motif; other site 526227007219 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 526227007220 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 526227007221 HIGH motif; other site 526227007222 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 526227007223 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 526227007224 active site 526227007225 KMSKS motif; other site 526227007226 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 526227007227 tRNA binding surface [nucleotide binding]; other site 526227007228 anticodon binding site; other site 526227007229 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 526227007230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 526227007231 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 526227007232 DHH family; Region: DHH; pfam01368 526227007233 DHHA1 domain; Region: DHHA1; pfam02272 526227007234 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 526227007235 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 526227007236 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 526227007237 catalytic residues [active] 526227007238 Arginase family; Region: Arginase; cd09989 526227007239 agmatinase; Region: agmatinase; TIGR01230 526227007240 active site 526227007241 Mn binding site [ion binding]; other site 526227007242 oligomer interface [polypeptide binding]; other site 526227007243 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 526227007244 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 526227007245 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 526227007246 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 526227007247 dimer interface [polypeptide binding]; other site 526227007248 active site 526227007249 CoA binding pocket [chemical binding]; other site 526227007250 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 526227007251 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 526227007252 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 526227007253 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 526227007254 NAD(P) binding site [chemical binding]; other site 526227007255 homotetramer interface [polypeptide binding]; other site 526227007256 homodimer interface [polypeptide binding]; other site 526227007257 active site 526227007258 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 526227007259 classical (c) SDRs; Region: SDR_c; cd05233 526227007260 NAD(P) binding site [chemical binding]; other site 526227007261 active site 526227007262 acyl carrier protein; Provisional; Region: acpP; PRK00982 526227007263 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 526227007264 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 526227007265 dimer interface [polypeptide binding]; other site 526227007266 active site 526227007267 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 526227007268 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227007269 Zn2+ binding site [ion binding]; other site 526227007270 Mg2+ binding site [ion binding]; other site 526227007271 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 526227007272 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 526227007273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227007274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227007275 homodimer interface [polypeptide binding]; other site 526227007276 catalytic residue [active] 526227007277 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14855 526227007278 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 526227007279 active site 526227007280 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 526227007281 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 526227007282 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227007283 MULE transposase domain; Region: MULE; pfam10551 526227007284 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 526227007285 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526227007286 RNA binding surface [nucleotide binding]; other site 526227007287 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 526227007288 active site 526227007289 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 526227007290 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227007291 Zn2+ binding site [ion binding]; other site 526227007292 Mg2+ binding site [ion binding]; other site 526227007293 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 526227007294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227007295 Walker A motif; other site 526227007296 ATP binding site [chemical binding]; other site 526227007297 Walker B motif; other site 526227007298 arginine finger; other site 526227007299 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 526227007300 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 526227007301 Response regulator receiver domain; Region: Response_reg; pfam00072 526227007302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 526227007303 active site 526227007304 phosphorylation site [posttranslational modification] 526227007305 dimerization interface [polypeptide binding]; other site 526227007306 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526227007307 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227007308 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 526227007309 Walker A/P-loop; other site 526227007310 ATP binding site [chemical binding]; other site 526227007311 Q-loop/lid; other site 526227007312 ABC transporter signature motif; other site 526227007313 Walker B; other site 526227007314 D-loop; other site 526227007315 H-loop/switch region; other site 526227007316 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227007317 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 526227007318 Walker A/P-loop; other site 526227007319 ATP binding site [chemical binding]; other site 526227007320 Q-loop/lid; other site 526227007321 ABC transporter signature motif; other site 526227007322 Walker B; other site 526227007323 D-loop; other site 526227007324 H-loop/switch region; other site 526227007325 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 526227007326 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 526227007327 putative ligand binding site [chemical binding]; other site 526227007328 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227007329 TM-ABC transporter signature motif; other site 526227007330 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 526227007331 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227007332 TM-ABC transporter signature motif; other site 526227007333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227007334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526227007335 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 526227007336 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 526227007337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227007338 DNA-binding site [nucleotide binding]; DNA binding site 526227007339 UTRA domain; Region: UTRA; pfam07702 526227007340 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227007341 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 526227007342 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227007343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007344 dimer interface [polypeptide binding]; other site 526227007345 conserved gate region; other site 526227007346 putative PBP binding loops; other site 526227007347 ABC-ATPase subunit interface; other site 526227007348 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 526227007349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007350 dimer interface [polypeptide binding]; other site 526227007351 conserved gate region; other site 526227007352 putative PBP binding loops; other site 526227007353 ABC-ATPase subunit interface; other site 526227007354 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526227007355 Beta-lactamase; Region: Beta-lactamase; pfam00144 526227007356 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 526227007357 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 526227007358 putative active site [active] 526227007359 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227007360 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 526227007361 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227007362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007363 dimer interface [polypeptide binding]; other site 526227007364 conserved gate region; other site 526227007365 putative PBP binding loops; other site 526227007366 ABC-ATPase subunit interface; other site 526227007367 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 526227007368 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 526227007369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007370 dimer interface [polypeptide binding]; other site 526227007371 conserved gate region; other site 526227007372 putative PBP binding loops; other site 526227007373 ABC-ATPase subunit interface; other site 526227007374 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227007375 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 526227007376 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 526227007377 Stage II sporulation protein; Region: SpoIID; pfam08486 526227007378 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 526227007379 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 526227007380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227007381 Coenzyme A binding pocket [chemical binding]; other site 526227007382 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 526227007383 intersubunit interface [polypeptide binding]; other site 526227007384 active site 526227007385 catalytic residue [active] 526227007386 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 526227007387 PLD-like domain; Region: PLDc_2; pfam13091 526227007388 putative active site [active] 526227007389 catalytic site [active] 526227007390 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 526227007391 PLD-like domain; Region: PLDc_2; pfam13091 526227007392 putative active site [active] 526227007393 catalytic site [active] 526227007394 Maf-like protein; Region: Maf; pfam02545 526227007395 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 526227007396 active site 526227007397 dimer interface [polypeptide binding]; other site 526227007398 rod shape-determining protein MreC; Provisional; Region: PRK13922 526227007399 rod shape-determining protein MreC; Region: MreC; pfam04085 526227007400 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 526227007401 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 526227007402 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 526227007403 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 526227007404 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 526227007405 Protein of unknown function (DUF420); Region: DUF420; pfam04238 526227007406 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 526227007407 dimer interface [polypeptide binding]; other site 526227007408 putative tRNA-binding site [nucleotide binding]; other site 526227007409 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 526227007410 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 526227007411 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227007412 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 526227007413 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 526227007414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227007415 S-adenosylmethionine binding site [chemical binding]; other site 526227007416 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 526227007417 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526227007418 substrate binding site [chemical binding]; other site 526227007419 ATP binding site [chemical binding]; other site 526227007420 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 526227007421 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 526227007422 putative active site [active] 526227007423 oxyanion strand; other site 526227007424 catalytic triad [active] 526227007425 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 526227007426 putative active site pocket [active] 526227007427 4-fold oligomerization interface [polypeptide binding]; other site 526227007428 metal binding residues [ion binding]; metal-binding site 526227007429 3-fold/trimer interface [polypeptide binding]; other site 526227007430 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 526227007431 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227007432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227007433 homodimer interface [polypeptide binding]; other site 526227007434 catalytic residue [active] 526227007435 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 526227007436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227007437 TPR motif; other site 526227007438 binding surface 526227007439 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 526227007440 Found in ATP-dependent protease La (LON); Region: LON; smart00464 526227007441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227007442 Walker A motif; other site 526227007443 ATP binding site [chemical binding]; other site 526227007444 Walker B motif; other site 526227007445 arginine finger; other site 526227007446 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 526227007447 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 526227007448 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526227007449 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526227007450 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 526227007451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227007452 Zn2+ binding site [ion binding]; other site 526227007453 Mg2+ binding site [ion binding]; other site 526227007454 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 526227007455 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007456 active site residue [active] 526227007457 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007458 active site residue [active] 526227007459 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007460 active site residue [active] 526227007461 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 526227007462 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007463 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007464 active site residue [active] 526227007465 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227007466 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 526227007467 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 526227007468 catalytic residues [active] 526227007469 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227007470 active site residue [active] 526227007471 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 526227007472 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 526227007473 catalytic residues [active] 526227007474 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 526227007475 putative homodimer interface [polypeptide binding]; other site 526227007476 putative homotetramer interface [polypeptide binding]; other site 526227007477 putative allosteric switch controlling residues; other site 526227007478 putative metal binding site [ion binding]; other site 526227007479 putative homodimer-homodimer interface [polypeptide binding]; other site 526227007480 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 526227007481 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 526227007482 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227007483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227007484 active site 526227007485 phosphorylation site [posttranslational modification] 526227007486 intermolecular recognition site; other site 526227007487 dimerization interface [polypeptide binding]; other site 526227007488 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227007489 DNA binding site [nucleotide binding] 526227007490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227007491 HAMP domain; Region: HAMP; pfam00672 526227007492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227007493 dimer interface [polypeptide binding]; other site 526227007494 phosphorylation site [posttranslational modification] 526227007495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227007496 ATP binding site [chemical binding]; other site 526227007497 Mg2+ binding site [ion binding]; other site 526227007498 G-X-G motif; other site 526227007499 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 526227007500 H+ Antiporter protein; Region: 2A0121; TIGR00900 526227007501 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 526227007502 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 526227007503 Zn binding site [ion binding]; other site 526227007504 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 526227007505 active site 526227007506 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 526227007507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227007508 S-adenosylmethionine binding site [chemical binding]; other site 526227007509 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227007510 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227007511 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 526227007512 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 526227007513 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227007514 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526227007515 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526227007516 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227007517 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526227007518 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526227007519 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227007520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007521 dimer interface [polypeptide binding]; other site 526227007522 conserved gate region; other site 526227007523 putative PBP binding loops; other site 526227007524 ABC-ATPase subunit interface; other site 526227007525 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 526227007526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007527 dimer interface [polypeptide binding]; other site 526227007528 conserved gate region; other site 526227007529 putative PBP binding loops; other site 526227007530 ABC-ATPase subunit interface; other site 526227007531 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227007532 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227007533 DNA topoisomerase I; Validated; Region: PRK06599 526227007534 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 526227007535 active site 526227007536 interdomain interaction site; other site 526227007537 putative metal-binding site [ion binding]; other site 526227007538 nucleotide binding site [chemical binding]; other site 526227007539 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 526227007540 domain I; other site 526227007541 DNA binding groove [nucleotide binding] 526227007542 phosphate binding site [ion binding]; other site 526227007543 domain II; other site 526227007544 domain III; other site 526227007545 nucleotide binding site [chemical binding]; other site 526227007546 catalytic site [active] 526227007547 domain IV; other site 526227007548 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 526227007549 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 526227007550 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 526227007551 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 526227007552 LysE type translocator; Region: LysE; cl00565 526227007553 Uncharacterized conserved protein [Function unknown]; Region: COG1432 526227007554 LabA_like proteins; Region: LabA_like/DUF88; cl10034 526227007555 putative metal binding site [ion binding]; other site 526227007556 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 526227007557 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227007558 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227007559 Transposase [DNA replication, recombination, and repair]; Region: COG5421 526227007560 CARDB; Region: CARDB; pfam07705 526227007561 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 526227007562 active site 526227007563 gamma-glutamyl kinase; Provisional; Region: PRK05429 526227007564 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 526227007565 nucleotide binding site [chemical binding]; other site 526227007566 homotetrameric interface [polypeptide binding]; other site 526227007567 putative phosphate binding site [ion binding]; other site 526227007568 putative allosteric binding site; other site 526227007569 PUA domain; Region: PUA; pfam01472 526227007570 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 526227007571 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 526227007572 putative catalytic cysteine [active] 526227007573 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 526227007574 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 526227007575 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 526227007576 NodB motif; other site 526227007577 active site 526227007578 catalytic site [active] 526227007579 metal binding site [ion binding]; metal-binding site 526227007580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 526227007581 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 526227007582 core dimer interface [polypeptide binding]; other site 526227007583 peripheral dimer interface [polypeptide binding]; other site 526227007584 L10 interface [polypeptide binding]; other site 526227007585 L11 interface [polypeptide binding]; other site 526227007586 putative EF-Tu interaction site [polypeptide binding]; other site 526227007587 putative EF-G interaction site [polypeptide binding]; other site 526227007588 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 526227007589 23S rRNA interface [nucleotide binding]; other site 526227007590 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 526227007591 putative transposase OrfB; Reviewed; Region: PHA02517 526227007592 Integrase core domain; Region: rve; pfam00665 526227007593 Integrase core domain; Region: rve_3; pfam13683 526227007594 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 526227007595 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 526227007596 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 526227007597 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 526227007598 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 526227007599 BNR repeat-like domain; Region: BNR_2; pfam13088 526227007600 Predicted transcriptional regulator [Transcription]; Region: COG2378 526227007601 HTH domain; Region: HTH_11; pfam08279 526227007602 WYL domain; Region: WYL; pfam13280 526227007603 short chain dehydrogenase; Provisional; Region: PRK08303 526227007604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007605 NAD(P) binding site [chemical binding]; other site 526227007606 active site 526227007607 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 526227007608 mRNA/rRNA interface [nucleotide binding]; other site 526227007609 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 526227007610 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 526227007611 23S rRNA interface [nucleotide binding]; other site 526227007612 L7/L12 interface [polypeptide binding]; other site 526227007613 putative thiostrepton binding site; other site 526227007614 L25 interface [polypeptide binding]; other site 526227007615 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 526227007616 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 526227007617 putative homodimer interface [polypeptide binding]; other site 526227007618 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 526227007619 heterodimer interface [polypeptide binding]; other site 526227007620 homodimer interface [polypeptide binding]; other site 526227007621 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 526227007622 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 526227007623 elongation factor Tu; Reviewed; Region: PRK00049 526227007624 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 526227007625 G1 box; other site 526227007626 GEF interaction site [polypeptide binding]; other site 526227007627 GTP/Mg2+ binding site [chemical binding]; other site 526227007628 Switch I region; other site 526227007629 G2 box; other site 526227007630 G3 box; other site 526227007631 Switch II region; other site 526227007632 G4 box; other site 526227007633 G5 box; other site 526227007634 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 526227007635 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 526227007636 Antibiotic Binding Site [chemical binding]; other site 526227007637 putative transposase OrfB; Reviewed; Region: PHA02517 526227007638 Integrase core domain; Region: rve; pfam00665 526227007639 Integrase core domain; Region: rve_3; pfam13683 526227007640 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 526227007641 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526227007642 Beta-Casp domain; Region: Beta-Casp; smart01027 526227007643 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 526227007644 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 526227007645 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 526227007646 putative hydrophobic ligand binding site [chemical binding]; other site 526227007647 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 526227007648 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 526227007649 Ligand binding site; other site 526227007650 metal-binding site 526227007651 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 526227007652 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526227007653 catalytic loop [active] 526227007654 iron binding site [ion binding]; other site 526227007655 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 526227007656 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 526227007657 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 526227007658 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 526227007659 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 526227007660 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 526227007661 MoxR-like ATPases [General function prediction only]; Region: COG0714 526227007662 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 526227007663 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227007664 metal ion-dependent adhesion site (MIDAS); other site 526227007665 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 526227007666 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 526227007667 XdhC Rossmann domain; Region: XdhC_C; pfam13478 526227007668 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 526227007669 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 526227007670 GTP binding site; other site 526227007671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526227007672 Histidine kinase; Region: HisKA_3; pfam07730 526227007673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227007674 ATP binding site [chemical binding]; other site 526227007675 Mg2+ binding site [ion binding]; other site 526227007676 G-X-G motif; other site 526227007677 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 526227007678 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 526227007679 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 526227007680 Transglycosylase; Region: Transgly; pfam00912 526227007681 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 526227007682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 526227007683 active site 526227007684 phosphorylation site [posttranslational modification] 526227007685 intermolecular recognition site; other site 526227007686 dimerization interface [polypeptide binding]; other site 526227007687 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227007688 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227007689 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 526227007690 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 526227007691 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 526227007692 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227007693 active site 526227007694 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 526227007695 active site 526227007696 dimer interface [polypeptide binding]; other site 526227007697 putative transposase OrfB; Reviewed; Region: PHA02517 526227007698 Integrase core domain; Region: rve; pfam00665 526227007699 Integrase core domain; Region: rve_3; pfam13683 526227007700 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 526227007701 Chain length determinant protein; Region: Wzz; cl15801 526227007702 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 526227007703 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 526227007704 putative transposase OrfB; Reviewed; Region: PHA02517 526227007705 Integrase core domain; Region: rve; pfam00665 526227007706 Integrase core domain; Region: rve_3; pfam13683 526227007707 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227007708 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 526227007709 Imelysin; Region: Peptidase_M75; pfam09375 526227007710 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 526227007711 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 526227007712 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 526227007713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007714 dimer interface [polypeptide binding]; other site 526227007715 conserved gate region; other site 526227007716 putative PBP binding loops; other site 526227007717 ABC-ATPase subunit interface; other site 526227007718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007719 putative PBP binding loops; other site 526227007720 dimer interface [polypeptide binding]; other site 526227007721 ABC-ATPase subunit interface; other site 526227007722 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227007723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227007724 Walker A/P-loop; other site 526227007725 ATP binding site [chemical binding]; other site 526227007726 Q-loop/lid; other site 526227007727 ABC transporter signature motif; other site 526227007728 Walker B; other site 526227007729 D-loop; other site 526227007730 H-loop/switch region; other site 526227007731 TOBE domain; Region: TOBE_2; pfam08402 526227007732 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 526227007733 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 526227007734 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 526227007735 dimerization interface 3.5A [polypeptide binding]; other site 526227007736 active site 526227007737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 526227007738 conserved hypothetical protein; Region: TIGR03492 526227007739 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526227007740 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 526227007741 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526227007742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007743 putative PBP binding loops; other site 526227007744 dimer interface [polypeptide binding]; other site 526227007745 ABC-ATPase subunit interface; other site 526227007746 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526227007747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007748 putative PBP binding loops; other site 526227007749 ABC-ATPase subunit interface; other site 526227007750 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227007751 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 526227007752 peptide binding site [polypeptide binding]; other site 526227007753 dimer interface [polypeptide binding]; other site 526227007754 putative transposase OrfB; Reviewed; Region: PHA02517 526227007755 Integrase core domain; Region: rve; pfam00665 526227007756 Integrase core domain; Region: rve_3; pfam13683 526227007757 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 526227007758 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 526227007759 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 526227007760 active site 526227007761 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 526227007762 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 526227007763 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227007764 active site 526227007765 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 526227007766 O-Antigen ligase; Region: Wzy_C; pfam04932 526227007767 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 526227007768 Bacterial sugar transferase; Region: Bac_transf; pfam02397 526227007769 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526227007770 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227007771 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227007772 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227007773 active site 526227007774 O-Antigen ligase; Region: Wzy_C; pfam04932 526227007775 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227007776 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227007777 active site 526227007778 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526227007779 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 526227007780 Probable Catalytic site; other site 526227007781 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 526227007782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526227007783 UDP-galactopyranose mutase; Region: GLF; pfam03275 526227007784 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 526227007785 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 526227007786 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 526227007787 active site 526227007788 NTP binding site [chemical binding]; other site 526227007789 metal binding triad [ion binding]; metal-binding site 526227007790 antibiotic binding site [chemical binding]; other site 526227007791 HEPN domain; Region: HEPN; pfam05168 526227007792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007793 NAD(P) binding site [chemical binding]; other site 526227007794 active site 526227007795 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 526227007796 thioester formation/cholesterol transfer; other site 526227007797 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 526227007798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007799 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 526227007800 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 526227007801 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 526227007802 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 526227007803 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 526227007804 NAD binding site [chemical binding]; other site 526227007805 substrate binding site [chemical binding]; other site 526227007806 homodimer interface [polypeptide binding]; other site 526227007807 active site 526227007808 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 526227007809 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 526227007810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227007811 NAD(P) binding site [chemical binding]; other site 526227007812 active site 526227007813 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 526227007814 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 526227007815 substrate binding site; other site 526227007816 metal-binding site 526227007817 Oligomer interface; other site 526227007818 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 526227007819 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 526227007820 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 526227007821 Substrate binding site; other site 526227007822 Cupin domain; Region: Cupin_2; cl17218 526227007823 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 526227007824 nudix motif; other site 526227007825 peptide chain release factor 1; Validated; Region: prfA; PRK00591 526227007826 PCRF domain; Region: PCRF; pfam03462 526227007827 RF-1 domain; Region: RF-1; pfam00472 526227007828 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 526227007829 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 526227007830 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 526227007831 FeoA domain; Region: FeoA; pfam04023 526227007832 manganese transport protein MntH; Reviewed; Region: PRK00701 526227007833 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 526227007834 putative transposase OrfB; Reviewed; Region: PHA02517 526227007835 Integrase core domain; Region: rve; pfam00665 526227007836 Integrase core domain; Region: rve_3; pfam13683 526227007837 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 526227007838 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 526227007839 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227007840 Ligand Binding Site [chemical binding]; other site 526227007841 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 526227007842 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 526227007843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227007844 putative substrate translocation pore; other site 526227007845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227007846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227007847 Walker A/P-loop; other site 526227007848 ATP binding site [chemical binding]; other site 526227007849 Q-loop/lid; other site 526227007850 ABC transporter signature motif; other site 526227007851 Walker B; other site 526227007852 D-loop; other site 526227007853 H-loop/switch region; other site 526227007854 ATP-binding cassette domain of MutS homologs; Region: ABC_MutS_homologs; cd03243 526227007855 Walker A/P-loop; other site 526227007856 ATP binding site [chemical binding]; other site 526227007857 Q-loop/lid; other site 526227007858 ABC transporter signature motif; other site 526227007859 Walker B; other site 526227007860 D-loop; other site 526227007861 H-loop/switch region; other site 526227007862 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 526227007863 Transcriptional regulator [Transcription]; Region: LysR; COG0583 526227007864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 526227007865 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 526227007866 putative dimerization interface [polypeptide binding]; other site 526227007867 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 526227007868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526227007869 putative anti-sigmaE protein; Provisional; Region: PRK13920 526227007870 Putative zinc-finger; Region: zf-HC2; pfam13490 526227007871 Cupin domain; Region: Cupin_2; cl17218 526227007872 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 526227007873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227007874 Probable transposase; Region: OrfB_IS605; pfam01385 526227007875 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227007876 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 526227007877 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 526227007878 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526227007879 sulfite oxidase; Provisional; Region: PLN00177 526227007880 Moco binding site; other site 526227007881 metal coordination site [ion binding]; other site 526227007882 Dihaem cytochrome c; Region: DHC; pfam09626 526227007883 Cytochrome c; Region: Cytochrom_C; pfam00034 526227007884 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 526227007885 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 526227007886 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 526227007887 GatB domain; Region: GatB_Yqey; smart00845 526227007888 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 526227007889 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 526227007890 dimerization interface [polypeptide binding]; other site 526227007891 putative ATP binding site [chemical binding]; other site 526227007892 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526227007893 catalytic core [active] 526227007894 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 526227007895 classical (c) SDRs; Region: SDR_c; cd05233 526227007896 NAD(P) binding site [chemical binding]; other site 526227007897 active site 526227007898 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 526227007899 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 526227007900 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227007901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007902 dimer interface [polypeptide binding]; other site 526227007903 conserved gate region; other site 526227007904 putative PBP binding loops; other site 526227007905 ABC-ATPase subunit interface; other site 526227007906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227007907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007908 putative PBP binding loops; other site 526227007909 ABC-ATPase subunit interface; other site 526227007910 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227007911 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227007912 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227007913 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227007914 DNA binding site [nucleotide binding] 526227007915 domain linker motif; other site 526227007916 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227007917 ligand binding site [chemical binding]; other site 526227007918 dimerization interface [polypeptide binding]; other site 526227007919 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 526227007920 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 526227007921 substrate binding site; other site 526227007922 metal-binding site 526227007923 Oligomer interface; other site 526227007924 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 526227007925 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 526227007926 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 526227007927 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526227007928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 526227007929 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 526227007930 Domain of unknown function DUF11; Region: DUF11; pfam01345 526227007931 Domain of unknown function DUF11; Region: DUF11; cl17728 526227007932 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 526227007933 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 526227007934 legume lectins; Region: lectin_L-type; cl14058 526227007935 homotetramer interaction site [polypeptide binding]; other site 526227007936 carbohydrate binding site [chemical binding]; other site 526227007937 metal binding site [ion binding]; metal-binding site 526227007938 Domain of unknown function DUF11; Region: DUF11; pfam01345 526227007939 Domain of unknown function DUF11; Region: DUF11; cl17728 526227007940 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227007941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227007942 active site 526227007943 phosphorylation site [posttranslational modification] 526227007944 intermolecular recognition site; other site 526227007945 dimerization interface [polypeptide binding]; other site 526227007946 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227007947 DNA binding site [nucleotide binding] 526227007948 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 526227007949 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 526227007950 [2Fe-2S] cluster binding site [ion binding]; other site 526227007951 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 526227007952 hydrophobic ligand binding site; other site 526227007953 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 526227007954 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 526227007955 substrate binding pocket [chemical binding]; other site 526227007956 membrane-bound complex binding site; other site 526227007957 hinge residues; other site 526227007958 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 526227007959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227007960 dimer interface [polypeptide binding]; other site 526227007961 conserved gate region; other site 526227007962 putative PBP binding loops; other site 526227007963 ABC-ATPase subunit interface; other site 526227007964 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 526227007965 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 526227007966 Walker A/P-loop; other site 526227007967 ATP binding site [chemical binding]; other site 526227007968 Q-loop/lid; other site 526227007969 ABC transporter signature motif; other site 526227007970 Walker B; other site 526227007971 D-loop; other site 526227007972 H-loop/switch region; other site 526227007973 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 526227007974 heterotetramer interface [polypeptide binding]; other site 526227007975 active site pocket [active] 526227007976 cleavage site 526227007977 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 526227007978 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 526227007979 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 526227007980 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 526227007981 ornithine carbamoyltransferase; Provisional; Region: PRK00779 526227007982 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 526227007983 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 526227007984 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526227007985 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 526227007986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227007987 putative substrate translocation pore; other site 526227007988 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 526227007989 membrane protein; Provisional; Region: PRK14402 526227007990 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 526227007991 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 526227007992 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 526227007993 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 526227007994 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 526227007995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227007996 Walker A/P-loop; other site 526227007997 ATP binding site [chemical binding]; other site 526227007998 Q-loop/lid; other site 526227007999 ABC transporter signature motif; other site 526227008000 Walker B; other site 526227008001 D-loop; other site 526227008002 H-loop/switch region; other site 526227008003 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 526227008004 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 526227008005 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 526227008006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227008007 TPR repeat; Region: TPR_11; pfam13414 526227008008 binding surface 526227008009 TPR motif; other site 526227008010 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 526227008011 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 526227008012 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 526227008013 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 526227008014 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 526227008015 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 526227008016 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 526227008017 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 526227008018 Active site serine [active] 526227008019 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 526227008020 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 526227008021 protein binding site [polypeptide binding]; other site 526227008022 Peptidase family S41; Region: Peptidase_S41; pfam03572 526227008023 Active site serine [active] 526227008024 Stage II sporulation protein; Region: SpoIID; pfam08486 526227008025 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 526227008026 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 526227008027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 526227008028 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 526227008029 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526227008030 ligand binding site [chemical binding]; other site 526227008031 flexible hinge region; other site 526227008032 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 526227008033 non-specific DNA interactions [nucleotide binding]; other site 526227008034 DNA binding site [nucleotide binding] 526227008035 sequence specific DNA binding site [nucleotide binding]; other site 526227008036 putative cAMP binding site [chemical binding]; other site 526227008037 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 526227008038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 526227008039 non-specific DNA binding site [nucleotide binding]; other site 526227008040 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 526227008041 salt bridge; other site 526227008042 sequence-specific DNA binding site [nucleotide binding]; other site 526227008043 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 526227008044 Catalytic site [active] 526227008045 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 526227008046 oligomer interface [polypeptide binding]; other site 526227008047 Cytochrome c; Region: Cytochrom_C; pfam00034 526227008048 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 526227008049 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227008050 ssDNA binding site [nucleotide binding]; other site 526227008051 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227008052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 526227008053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227008054 dimer interface [polypeptide binding]; other site 526227008055 ssDNA binding site [nucleotide binding]; other site 526227008056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227008057 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 526227008058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227008059 ATP binding site [chemical binding]; other site 526227008060 putative Mg++ binding site [ion binding]; other site 526227008061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227008062 nucleotide binding region [chemical binding]; other site 526227008063 ATP-binding site [chemical binding]; other site 526227008064 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 526227008065 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 526227008066 CAAX protease self-immunity; Region: Abi; pfam02517 526227008067 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 526227008068 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227008069 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 526227008070 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227008071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227008072 active site 526227008073 phosphorylation site [posttranslational modification] 526227008074 intermolecular recognition site; other site 526227008075 dimerization interface [polypeptide binding]; other site 526227008076 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227008077 DNA binding residues [nucleotide binding] 526227008078 dimerization interface [polypeptide binding]; other site 526227008079 PAS domain S-box; Region: sensory_box; TIGR00229 526227008080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526227008081 putative active site [active] 526227008082 heme pocket [chemical binding]; other site 526227008083 GAF domain; Region: GAF; pfam01590 526227008084 GAF domain; Region: GAF_2; pfam13185 526227008085 GAF domain; Region: GAF_3; pfam13492 526227008086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227008087 Histidine kinase; Region: HisKA_3; pfam07730 526227008088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227008089 ATP binding site [chemical binding]; other site 526227008090 Mg2+ binding site [ion binding]; other site 526227008091 G-X-G motif; other site 526227008092 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 526227008093 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 526227008094 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 526227008095 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 526227008096 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 526227008097 Walker A/P-loop; other site 526227008098 ATP binding site [chemical binding]; other site 526227008099 Q-loop/lid; other site 526227008100 ABC transporter signature motif; other site 526227008101 Walker B; other site 526227008102 D-loop; other site 526227008103 H-loop/switch region; other site 526227008104 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 526227008105 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227008106 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526227008107 TM-ABC transporter signature motif; other site 526227008108 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227008109 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526227008110 TM-ABC transporter signature motif; other site 526227008111 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 526227008112 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 526227008113 ligand binding site [chemical binding]; other site 526227008114 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 526227008115 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 526227008116 short chain dehydrogenase; Validated; Region: PRK08324 526227008117 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 526227008118 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 526227008119 putative NAD(P) binding site [chemical binding]; other site 526227008120 active site 526227008121 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 526227008122 N- and C-terminal domain interface [polypeptide binding]; other site 526227008123 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 526227008124 active site 526227008125 putative catalytic site [active] 526227008126 metal binding site [ion binding]; metal-binding site 526227008127 ATP binding site [chemical binding]; other site 526227008128 carbohydrate binding site [chemical binding]; other site 526227008129 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 526227008130 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227008131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 526227008132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526227008133 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526227008134 MarR family; Region: MarR; pfam01047 526227008135 Protoglobin; Region: Protoglobin; pfam11563 526227008136 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 526227008137 active site 526227008138 catalytic site [active] 526227008139 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 526227008140 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 526227008141 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 526227008142 active site 526227008143 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 526227008144 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 526227008145 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 526227008146 phosphopeptide binding site; other site 526227008147 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 526227008148 Double zinc ribbon; Region: DZR; pfam12773 526227008149 Protein kinase domain; Region: Pkinase; pfam00069 526227008150 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526227008151 active site 526227008152 ATP binding site [chemical binding]; other site 526227008153 substrate binding site [chemical binding]; other site 526227008154 activation loop (A-loop); other site 526227008155 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 526227008156 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 526227008157 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227008158 metal ion-dependent adhesion site (MIDAS); other site 526227008159 putative transposase OrfB; Reviewed; Region: PHA02517 526227008160 Integrase core domain; Region: rve; pfam00665 526227008161 Integrase core domain; Region: rve_3; pfam13683 526227008162 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 526227008163 nucleotide binding site [chemical binding]; other site 526227008164 N-acetyl-L-glutamate binding site [chemical binding]; other site 526227008165 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526227008166 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 526227008167 putative NAD(P) binding site [chemical binding]; other site 526227008168 structural Zn binding site [ion binding]; other site 526227008169 Uncharacterized conserved protein [Function unknown]; Region: COG1432 526227008170 LabA_like proteins; Region: LabA_like/DUF88; cl10034 526227008171 putative metal binding site [ion binding]; other site 526227008172 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 526227008173 Protein of unknown function (DUF402); Region: DUF402; pfam04167 526227008174 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 526227008175 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 526227008176 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 526227008177 alphaNTD - beta interaction site [polypeptide binding]; other site 526227008178 alphaNTD homodimer interface [polypeptide binding]; other site 526227008179 alphaNTD - beta' interaction site [polypeptide binding]; other site 526227008180 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 526227008181 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 526227008182 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 526227008183 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526227008184 RNA binding surface [nucleotide binding]; other site 526227008185 30S ribosomal protein S11; Validated; Region: PRK05309 526227008186 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 526227008187 30S ribosomal protein S13; Region: bact_S13; TIGR03631 526227008188 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 526227008189 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 526227008190 rRNA binding site [nucleotide binding]; other site 526227008191 predicted 30S ribosome binding site; other site 526227008192 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 526227008193 active site 526227008194 adenylate kinase; Provisional; Region: PRK14527 526227008195 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 526227008196 AMP-binding site [chemical binding]; other site 526227008197 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 526227008198 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 526227008199 SecY translocase; Region: SecY; pfam00344 526227008200 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 526227008201 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 526227008202 23S rRNA binding site [nucleotide binding]; other site 526227008203 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 526227008204 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 526227008205 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 526227008206 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 526227008207 5S rRNA interface [nucleotide binding]; other site 526227008208 23S rRNA interface [nucleotide binding]; other site 526227008209 L5 interface [polypeptide binding]; other site 526227008210 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 526227008211 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 526227008212 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 526227008213 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 526227008214 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 526227008215 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 526227008216 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 526227008217 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 526227008218 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 526227008219 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 526227008220 RNA binding site [nucleotide binding]; other site 526227008221 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 526227008222 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 526227008223 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 526227008224 23S rRNA interface [nucleotide binding]; other site 526227008225 putative translocon interaction site; other site 526227008226 signal recognition particle (SRP54) interaction site; other site 526227008227 L23 interface [polypeptide binding]; other site 526227008228 trigger factor interaction site; other site 526227008229 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 526227008230 23S rRNA interface [nucleotide binding]; other site 526227008231 5S rRNA interface [nucleotide binding]; other site 526227008232 putative antibiotic binding site [chemical binding]; other site 526227008233 L25 interface [polypeptide binding]; other site 526227008234 L27 interface [polypeptide binding]; other site 526227008235 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 526227008236 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 526227008237 G-X-X-G motif; other site 526227008238 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 526227008239 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 526227008240 putative translocon binding site; other site 526227008241 protein-rRNA interface [nucleotide binding]; other site 526227008242 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 526227008243 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 526227008244 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 526227008245 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 526227008246 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 526227008247 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 526227008248 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 526227008249 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 526227008250 elongation factor Tu; Reviewed; Region: PRK00049 526227008251 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 526227008252 G1 box; other site 526227008253 GEF interaction site [polypeptide binding]; other site 526227008254 GTP/Mg2+ binding site [chemical binding]; other site 526227008255 Switch I region; other site 526227008256 G2 box; other site 526227008257 G3 box; other site 526227008258 Switch II region; other site 526227008259 G4 box; other site 526227008260 G5 box; other site 526227008261 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 526227008262 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 526227008263 Antibiotic Binding Site [chemical binding]; other site 526227008264 elongation factor G; Reviewed; Region: PRK00007 526227008265 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 526227008266 G1 box; other site 526227008267 putative GEF interaction site [polypeptide binding]; other site 526227008268 GTP/Mg2+ binding site [chemical binding]; other site 526227008269 Switch I region; other site 526227008270 G2 box; other site 526227008271 G3 box; other site 526227008272 Switch II region; other site 526227008273 G4 box; other site 526227008274 G5 box; other site 526227008275 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 526227008276 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 526227008277 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 526227008278 30S ribosomal protein S7; Validated; Region: PRK05302 526227008279 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 526227008280 S17 interaction site [polypeptide binding]; other site 526227008281 S8 interaction site; other site 526227008282 16S rRNA interaction site [nucleotide binding]; other site 526227008283 streptomycin interaction site [chemical binding]; other site 526227008284 23S rRNA interaction site [nucleotide binding]; other site 526227008285 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 526227008286 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227008287 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227008288 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227008289 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 526227008290 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526227008291 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 526227008292 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 526227008293 Cu(I) binding site [ion binding]; other site 526227008294 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 526227008295 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 526227008296 homodimer interface [polypeptide binding]; other site 526227008297 metal binding site [ion binding]; metal-binding site 526227008298 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 526227008299 putative active site [active] 526227008300 putative CoA binding site [chemical binding]; other site 526227008301 nudix motif; other site 526227008302 metal binding site [ion binding]; metal-binding site 526227008303 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 526227008304 intracellular protease, PfpI family; Region: PfpI; TIGR01382 526227008305 proposed catalytic triad [active] 526227008306 conserved cys residue [active] 526227008307 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 526227008308 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227008309 inhibitor-cofactor binding pocket; inhibition site 526227008310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008311 catalytic residue [active] 526227008312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227008313 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227008314 putative substrate translocation pore; other site 526227008315 AsnC family; Region: AsnC_trans_reg; pfam01037 526227008316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227008317 sequence-specific DNA binding site [nucleotide binding]; other site 526227008318 salt bridge; other site 526227008319 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 526227008320 Domain of unknown function (DUF955); Region: DUF955; cl01076 526227008321 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 526227008322 nudix motif; other site 526227008323 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 526227008324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227008325 NAD(P) binding site [chemical binding]; other site 526227008326 active site 526227008327 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 526227008328 homodecamer interface [polypeptide binding]; other site 526227008329 GTP cyclohydrolase I; Provisional; Region: PLN03044 526227008330 active site 526227008331 putative catalytic site residues [active] 526227008332 zinc binding site [ion binding]; other site 526227008333 GTP-CH-I/GFRP interaction surface; other site 526227008334 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 526227008335 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 526227008336 Ligand binding site; other site 526227008337 Putative Catalytic site; other site 526227008338 DXD motif; other site 526227008339 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526227008340 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 526227008341 Probable Catalytic site; other site 526227008342 metal-binding site 526227008343 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227008344 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526227008345 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227008346 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 526227008347 DXD motif; other site 526227008348 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227008349 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227008350 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526227008351 WxcM-like, C-terminal; Region: FdtA; pfam05523 526227008352 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 526227008353 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 526227008354 inhibitor-cofactor binding pocket; inhibition site 526227008355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008356 catalytic residue [active] 526227008357 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 526227008358 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227008359 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526227008360 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526227008361 active site 526227008362 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 526227008363 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 526227008364 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 526227008365 substrate binding site; other site 526227008366 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 526227008367 extended (e) SDRs; Region: SDR_e; cd08946 526227008368 NAD(P) binding site [chemical binding]; other site 526227008369 active site 526227008370 substrate binding site [chemical binding]; other site 526227008371 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 526227008372 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526227008373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227008374 S-adenosylmethionine binding site [chemical binding]; other site 526227008375 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 526227008376 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526227008377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227008378 S-adenosylmethionine binding site [chemical binding]; other site 526227008379 Protein of unknown function (DUF3379); Region: DUF3379; pfam11859 526227008380 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 526227008381 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227008382 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526227008383 active site 526227008384 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 526227008385 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 526227008386 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526227008387 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526227008388 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526227008389 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526227008390 active site 526227008391 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526227008392 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 526227008393 active site 526227008394 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 526227008395 Homeodomain-like domain; Region: HTH_23; cl17451 526227008396 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 526227008397 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 526227008398 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526227008399 catalytic residue [active] 526227008400 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526227008401 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 526227008402 NAD binding site [chemical binding]; other site 526227008403 homodimer interface [polypeptide binding]; other site 526227008404 active site 526227008405 putative substrate binding site [chemical binding]; other site 526227008406 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 526227008407 intersubunit interface [polypeptide binding]; other site 526227008408 active site 526227008409 catalytic residue [active] 526227008410 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526227008411 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526227008412 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227008413 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526227008414 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526227008415 putative transposase OrfB; Reviewed; Region: PHA02517 526227008416 Integrase core domain; Region: rve; pfam00665 526227008417 Integrase core domain; Region: rve_3; pfam13683 526227008418 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 526227008419 conserved cys residue [active] 526227008420 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526227008421 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526227008422 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526227008423 CAAX protease self-immunity; Region: Abi; pfam02517 526227008424 Protein of unknown function (DUF1616); Region: DUF1616; pfam07760 526227008425 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 526227008426 putative active site [active] 526227008427 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 526227008428 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 526227008429 active site 526227008430 Transcriptional regulator PadR-like family; Region: PadR; cl17335 526227008431 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 526227008432 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 526227008433 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 526227008434 Predicted transcriptional regulators [Transcription]; Region: COG1510 526227008435 Response regulator receiver domain; Region: Response_reg; pfam00072 526227008436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227008437 active site 526227008438 phosphorylation site [posttranslational modification] 526227008439 intermolecular recognition site; other site 526227008440 dimerization interface [polypeptide binding]; other site 526227008441 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227008442 active site 526227008443 catalytic residues [active] 526227008444 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227008445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 526227008446 TPR motif; other site 526227008447 binding surface 526227008448 Response regulator receiver domain; Region: Response_reg; pfam00072 526227008449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227008450 active site 526227008451 phosphorylation site [posttranslational modification] 526227008452 intermolecular recognition site; other site 526227008453 dimerization interface [polypeptide binding]; other site 526227008454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526227008455 PAS fold; Region: PAS_3; pfam08447 526227008456 heme pocket [chemical binding]; other site 526227008457 putative active site [active] 526227008458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 526227008459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227008460 dimer interface [polypeptide binding]; other site 526227008461 phosphorylation site [posttranslational modification] 526227008462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227008463 ATP binding site [chemical binding]; other site 526227008464 Mg2+ binding site [ion binding]; other site 526227008465 G-X-G motif; other site 526227008466 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 526227008467 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526227008468 inhibitor-cofactor binding pocket; inhibition site 526227008469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008470 catalytic residue [active] 526227008471 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 526227008472 NAD(P) binding pocket [chemical binding]; other site 526227008473 porphobilinogen deaminase; Region: hemC; TIGR00212 526227008474 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 526227008475 domain interfaces; other site 526227008476 active site 526227008477 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 526227008478 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 526227008479 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 526227008480 active site 526227008481 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 526227008482 dimer interface [polypeptide binding]; other site 526227008483 active site 526227008484 Schiff base residues; other site 526227008485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227008486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227008487 ATP binding site [chemical binding]; other site 526227008488 Mg2+ binding site [ion binding]; other site 526227008489 G-X-G motif; other site 526227008490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227008491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227008492 active site 526227008493 phosphorylation site [posttranslational modification] 526227008494 intermolecular recognition site; other site 526227008495 dimerization interface [polypeptide binding]; other site 526227008496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227008497 DNA binding site [nucleotide binding] 526227008498 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 526227008499 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 526227008500 substrate binding site [chemical binding]; other site 526227008501 active site 526227008502 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 526227008503 ferrochelatase; Reviewed; Region: hemH; PRK00035 526227008504 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 526227008505 C-terminal domain interface [polypeptide binding]; other site 526227008506 active site 526227008507 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 526227008508 active site 526227008509 N-terminal domain interface [polypeptide binding]; other site 526227008510 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 526227008511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526227008512 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 526227008513 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227008514 FtsX-like permease family; Region: FtsX; pfam02687 526227008515 3D domain; Region: 3D; cl01439 526227008516 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 526227008517 DAK2 domain; Region: Dak2; pfam02734 526227008518 Asp23 family; Region: Asp23; pfam03780 526227008519 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 526227008520 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 526227008521 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 526227008522 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 526227008523 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 526227008524 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 526227008525 Moco binding site; other site 526227008526 metal coordination site [ion binding]; other site 526227008527 Nicotianamine synthase protein; Region: NAS; cl17658 526227008528 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 526227008529 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 526227008530 VanW like protein; Region: VanW; pfam04294 526227008531 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 526227008532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526227008533 active site 526227008534 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 526227008535 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526227008536 RNA binding surface [nucleotide binding]; other site 526227008537 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 526227008538 active site 526227008539 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 526227008540 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526227008541 substrate binding site [chemical binding]; other site 526227008542 oxyanion hole (OAH) forming residues; other site 526227008543 trimer interface [polypeptide binding]; other site 526227008544 tRNA pseudouridine synthase B; Provisional; Region: PRK14122 526227008545 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 526227008546 RNA binding site [nucleotide binding]; other site 526227008547 active site 526227008548 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 526227008549 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227008550 dimerization interface [polypeptide binding]; other site 526227008551 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 526227008552 putative DNA binding site [nucleotide binding]; other site 526227008553 putative Zn2+ binding site [ion binding]; other site 526227008554 AsnC family; Region: AsnC_trans_reg; pfam01037 526227008555 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 526227008556 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 526227008557 hexamer interface [polypeptide binding]; other site 526227008558 ligand binding site [chemical binding]; other site 526227008559 putative active site [active] 526227008560 NAD(P) binding site [chemical binding]; other site 526227008561 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 526227008562 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526227008563 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 526227008564 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 526227008565 Domain of unknown function DUF20; Region: UPF0118; pfam01594 526227008566 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 526227008567 Peptidase family M23; Region: Peptidase_M23; pfam01551 526227008568 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526227008569 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 526227008570 putative transposase OrfB; Reviewed; Region: PHA02517 526227008571 Integrase core domain; Region: rve; pfam00665 526227008572 Integrase core domain; Region: rve_3; pfam13683 526227008573 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 526227008574 aspartate aminotransferase; Provisional; Region: PRK05764 526227008575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227008576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008577 homodimer interface [polypeptide binding]; other site 526227008578 catalytic residue [active] 526227008579 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 526227008580 L-asparaginase II; Region: Asparaginase_II; pfam06089 526227008581 Domain of unknown function (DUF309); Region: DUF309; pfam03745 526227008582 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 526227008583 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 526227008584 catalytic residues [active] 526227008585 putative phosphate acyltransferase; Provisional; Region: PRK05331 526227008586 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 526227008587 Mechanosensitive ion channel; Region: MS_channel; pfam00924 526227008588 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227008589 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 526227008590 Carboxylesterase family; Region: COesterase; pfam00135 526227008591 substrate binding pocket [chemical binding]; other site 526227008592 catalytic triad [active] 526227008593 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 526227008594 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 526227008595 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 526227008596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227008597 Coenzyme A binding pocket [chemical binding]; other site 526227008598 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 526227008599 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526227008600 Coenzyme A binding pocket [chemical binding]; other site 526227008601 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 526227008602 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 526227008603 putative active site [active] 526227008604 Zn binding site [ion binding]; other site 526227008605 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 526227008606 active site 526227008607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227008608 Coenzyme A binding pocket [chemical binding]; other site 526227008609 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 526227008610 Active_site [active] 526227008611 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 526227008612 MoxR-like ATPases [General function prediction only]; Region: COG0714 526227008613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227008614 Walker A motif; other site 526227008615 ATP binding site [chemical binding]; other site 526227008616 Walker B motif; other site 526227008617 arginine finger; other site 526227008618 Protein of unknown function DUF58; Region: DUF58; pfam01882 526227008619 von Willebrand factor type A domain; Region: VWA_2; pfam13519 526227008620 metal ion-dependent adhesion site (MIDAS); other site 526227008621 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227008622 metal ion-dependent adhesion site (MIDAS); other site 526227008623 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 526227008624 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 526227008625 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 526227008626 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 526227008627 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 526227008628 Phenylacetic acid degradation B; Region: PaaB; cl01371 526227008629 Phenylacetic acid degradation B; Region: PaaB; cl01371 526227008630 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 526227008631 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 526227008632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526227008633 Coenzyme A binding pocket [chemical binding]; other site 526227008634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 526227008635 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227008636 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526227008637 active site 526227008638 metal binding site [ion binding]; metal-binding site 526227008639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 526227008640 Transposase; Region: HTH_Tnp_1; pfam01527 526227008641 putative transposase OrfB; Reviewed; Region: PHA02517 526227008642 Integrase core domain; Region: rve; pfam00665 526227008643 Integrase core domain; Region: rve_3; pfam13683 526227008644 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 526227008645 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 526227008646 N- and C-terminal domain interface [polypeptide binding]; other site 526227008647 putative active site [active] 526227008648 MgATP binding site [chemical binding]; other site 526227008649 catalytic site [active] 526227008650 metal binding site [ion binding]; metal-binding site 526227008651 putative xylulose binding site [chemical binding]; other site 526227008652 putative homodimer interface [polypeptide binding]; other site 526227008653 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 526227008654 N- and C-terminal domain interface [polypeptide binding]; other site 526227008655 D-xylulose kinase; Region: XylB; TIGR01312 526227008656 active site 526227008657 MgATP binding site [chemical binding]; other site 526227008658 catalytic site [active] 526227008659 metal binding site [ion binding]; metal-binding site 526227008660 xylulose binding site [chemical binding]; other site 526227008661 homodimer interface [polypeptide binding]; other site 526227008662 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 526227008663 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 526227008664 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 526227008665 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526227008666 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526227008667 NAD(P) binding site [chemical binding]; other site 526227008668 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227008669 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227008670 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 526227008671 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 526227008672 tetramer interface [polypeptide binding]; other site 526227008673 active site 526227008674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227008675 dimer interface [polypeptide binding]; other site 526227008676 conserved gate region; other site 526227008677 putative PBP binding loops; other site 526227008678 ABC-ATPase subunit interface; other site 526227008679 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227008680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227008681 dimer interface [polypeptide binding]; other site 526227008682 conserved gate region; other site 526227008683 ABC-ATPase subunit interface; other site 526227008684 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 526227008685 AP (apurinic/apyrimidinic) site pocket; other site 526227008686 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 526227008687 DNA interaction; other site 526227008688 Metal-binding active site; metal-binding site 526227008689 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227008690 MULE transposase domain; Region: MULE; pfam10551 526227008691 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 526227008692 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 526227008693 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 526227008694 uridine phosphorylase; Provisional; Region: PRK11178 526227008695 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 526227008696 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 526227008697 N- and C-terminal domain interface [polypeptide binding]; other site 526227008698 D-xylulose kinase; Region: XylB; TIGR01312 526227008699 active site 526227008700 MgATP binding site [chemical binding]; other site 526227008701 catalytic site [active] 526227008702 metal binding site [ion binding]; metal-binding site 526227008703 xylulose binding site [chemical binding]; other site 526227008704 homodimer interface [polypeptide binding]; other site 526227008705 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 526227008706 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526227008707 Moco binding site; other site 526227008708 metal coordination site [ion binding]; other site 526227008709 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 526227008710 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 526227008711 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 526227008712 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 526227008713 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526227008714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227008715 Walker A/P-loop; other site 526227008716 ATP binding site [chemical binding]; other site 526227008717 Q-loop/lid; other site 526227008718 ABC transporter signature motif; other site 526227008719 Walker B; other site 526227008720 D-loop; other site 526227008721 H-loop/switch region; other site 526227008722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227008723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526227008724 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 526227008725 putative FMN binding site [chemical binding]; other site 526227008726 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526227008727 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 526227008728 peptide binding site [polypeptide binding]; other site 526227008729 dimer interface [polypeptide binding]; other site 526227008730 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 526227008731 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 526227008732 Walker A/P-loop; other site 526227008733 ATP binding site [chemical binding]; other site 526227008734 Q-loop/lid; other site 526227008735 ABC transporter signature motif; other site 526227008736 Walker B; other site 526227008737 D-loop; other site 526227008738 H-loop/switch region; other site 526227008739 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 526227008740 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 526227008741 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526227008742 ABC-ATPase subunit interface; other site 526227008743 dimer interface [polypeptide binding]; other site 526227008744 putative PBP binding regions; other site 526227008745 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 526227008746 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 526227008747 putative binding site residues; other site 526227008748 putative transposase OrfB; Reviewed; Region: PHA02517 526227008749 Integrase core domain; Region: rve; pfam00665 526227008750 Integrase core domain; Region: rve_3; pfam13683 526227008751 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 526227008752 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 526227008753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526227008754 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 526227008755 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 526227008756 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 526227008757 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526227008758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227008759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526227008760 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 526227008761 putative active site pocket [active] 526227008762 cleavage site 526227008763 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 526227008764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227008765 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 526227008766 Probable transposase; Region: OrfB_IS605; pfam01385 526227008767 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227008768 putative transposase OrfB; Reviewed; Region: PHA02517 526227008769 Integrase core domain; Region: rve; pfam00665 526227008770 Integrase core domain; Region: rve_3; pfam13683 526227008771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526227008772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526227008773 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 526227008774 replicative DNA helicase; Region: DnaB; TIGR00665 526227008775 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 526227008776 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 526227008777 Walker A motif; other site 526227008778 ATP binding site [chemical binding]; other site 526227008779 Walker B motif; other site 526227008780 DNA binding loops [nucleotide binding] 526227008781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227008782 binding surface 526227008783 TPR motif; other site 526227008784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227008785 TPR motif; other site 526227008786 binding surface 526227008787 TPR repeat; Region: TPR_11; pfam13414 526227008788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227008789 binding surface 526227008790 TPR motif; other site 526227008791 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 526227008792 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 526227008793 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 526227008794 dimer interface [polypeptide binding]; other site 526227008795 motif 1; other site 526227008796 active site 526227008797 motif 2; other site 526227008798 motif 3; other site 526227008799 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 526227008800 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 526227008801 putative tRNA-binding site [nucleotide binding]; other site 526227008802 B3/4 domain; Region: B3_4; pfam03483 526227008803 tRNA synthetase B5 domain; Region: B5; smart00874 526227008804 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 526227008805 dimer interface [polypeptide binding]; other site 526227008806 motif 1; other site 526227008807 motif 3; other site 526227008808 motif 2; other site 526227008809 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 526227008810 methionine sulfoxide reductase A; Provisional; Region: PRK14054 526227008811 6-phosphofructokinase; Provisional; Region: PRK03202 526227008812 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 526227008813 active site 526227008814 ADP/pyrophosphate binding site [chemical binding]; other site 526227008815 dimerization interface [polypeptide binding]; other site 526227008816 allosteric effector site; other site 526227008817 fructose-1,6-bisphosphate binding site; other site 526227008818 Predicted methyltransferases [General function prediction only]; Region: COG0313 526227008819 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 526227008820 putative SAM binding site [chemical binding]; other site 526227008821 putative homodimer interface [polypeptide binding]; other site 526227008822 putative transposase OrfB; Reviewed; Region: PHA02517 526227008823 Integrase core domain; Region: rve; pfam00665 526227008824 Integrase core domain; Region: rve_3; pfam13683 526227008825 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227008826 MULE transposase domain; Region: MULE; pfam10551 526227008827 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 526227008828 active site 526227008829 Ap6A binding site [chemical binding]; other site 526227008830 nudix motif; other site 526227008831 metal binding site [ion binding]; metal-binding site 526227008832 Protein of unknown function (DUF2847); Region: DUF2847; cl17683 526227008833 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 526227008834 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 526227008835 Walker A; other site 526227008836 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 526227008837 homotrimer interaction site [polypeptide binding]; other site 526227008838 putative active site [active] 526227008839 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 526227008840 active site 526227008841 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 526227008842 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 526227008843 dimer interface [polypeptide binding]; other site 526227008844 TPP-binding site [chemical binding]; other site 526227008845 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 526227008846 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 526227008847 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526227008848 E3 interaction surface; other site 526227008849 lipoyl attachment site [posttranslational modification]; other site 526227008850 e3 binding domain; Region: E3_binding; pfam02817 526227008851 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 526227008852 arginine decarboxylase; Provisional; Region: PRK05354 526227008853 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 526227008854 dimer interface [polypeptide binding]; other site 526227008855 active site 526227008856 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 526227008857 catalytic residues [active] 526227008858 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 526227008859 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227008860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227008861 metal binding site [ion binding]; metal-binding site 526227008862 active site 526227008863 I-site; other site 526227008864 S-adenosylmethionine synthetase; Validated; Region: PRK05250 526227008865 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 526227008866 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 526227008867 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 526227008868 GAF domain; Region: GAF_3; pfam13492 526227008869 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526227008870 GAF domain; Region: GAF; pfam01590 526227008871 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526227008872 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526227008873 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 526227008874 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227008875 Zn2+ binding site [ion binding]; other site 526227008876 Mg2+ binding site [ion binding]; other site 526227008877 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 526227008878 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 526227008879 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526227008880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227008881 DNA-binding site [nucleotide binding]; DNA binding site 526227008882 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 526227008883 Proline dehydrogenase; Region: Pro_dh; cl03282 526227008884 Uncharacterized conserved protein [Function unknown]; Region: COG3603 526227008885 Family description; Region: ACT_7; pfam13840 526227008886 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 526227008887 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 526227008888 Glutamate binding site [chemical binding]; other site 526227008889 homodimer interface [polypeptide binding]; other site 526227008890 NAD binding site [chemical binding]; other site 526227008891 catalytic residues [active] 526227008892 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 526227008893 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227008894 Predicted membrane protein [Function unknown]; Region: COG4280 526227008895 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 526227008896 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 526227008897 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 526227008898 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 526227008899 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 526227008900 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 526227008901 Domain interface; other site 526227008902 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 526227008903 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 526227008904 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 526227008905 iron-sulfur cluster [ion binding]; other site 526227008906 [2Fe-2S] cluster binding site [ion binding]; other site 526227008907 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 526227008908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227008909 dimerization interface [polypeptide binding]; other site 526227008910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227008911 dimer interface [polypeptide binding]; other site 526227008912 phosphorylation site [posttranslational modification] 526227008913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227008914 ATP binding site [chemical binding]; other site 526227008915 Mg2+ binding site [ion binding]; other site 526227008916 G-X-G motif; other site 526227008917 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227008918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227008919 active site 526227008920 phosphorylation site [posttranslational modification] 526227008921 intermolecular recognition site; other site 526227008922 dimerization interface [polypeptide binding]; other site 526227008923 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227008924 DNA binding site [nucleotide binding] 526227008925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526227008926 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 526227008927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526227008928 dimer interface [polypeptide binding]; other site 526227008929 phosphorylation site [posttranslational modification] 526227008930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227008931 ATP binding site [chemical binding]; other site 526227008932 G-X-G motif; other site 526227008933 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526227008934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227008935 active site 526227008936 phosphorylation site [posttranslational modification] 526227008937 intermolecular recognition site; other site 526227008938 dimerization interface [polypeptide binding]; other site 526227008939 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526227008940 DNA binding site [nucleotide binding] 526227008941 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 526227008942 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 526227008943 active site 526227008944 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 526227008945 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 526227008946 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526227008947 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 526227008948 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526227008949 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 526227008950 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 526227008951 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 526227008952 homodimer interface [polypeptide binding]; other site 526227008953 substrate-cofactor binding pocket; other site 526227008954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008955 catalytic residue [active] 526227008956 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 526227008957 Alkaline phosphatase homologues; Region: alkPPc; smart00098 526227008958 active site 526227008959 dimer interface [polypeptide binding]; other site 526227008960 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 526227008961 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 526227008962 Walker A/P-loop; other site 526227008963 ATP binding site [chemical binding]; other site 526227008964 Q-loop/lid; other site 526227008965 ABC transporter signature motif; other site 526227008966 Walker B; other site 526227008967 D-loop; other site 526227008968 H-loop/switch region; other site 526227008969 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227008970 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 526227008971 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227008972 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 526227008973 amphipathic channel; other site 526227008974 Asn-Pro-Ala signature motifs; other site 526227008975 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 526227008976 Fe-S cluster binding site [ion binding]; other site 526227008977 DNA binding site [nucleotide binding] 526227008978 active site 526227008979 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 526227008980 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 526227008981 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 526227008982 putative transposase OrfB; Reviewed; Region: PHA02517 526227008983 Integrase core domain; Region: rve; pfam00665 526227008984 Integrase core domain; Region: rve_3; pfam13683 526227008985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526227008986 S-adenosylmethionine binding site [chemical binding]; other site 526227008987 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 526227008988 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227008989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227008990 homodimer interface [polypeptide binding]; other site 526227008991 catalytic residue [active] 526227008992 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 526227008993 active site residue [active] 526227008994 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227008995 active site residue [active] 526227008996 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526227008997 Transposase [DNA replication, recombination, and repair]; Region: COG5421 526227008998 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 526227008999 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 526227009000 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526227009001 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 526227009002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227009003 motif II; other site 526227009004 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 526227009005 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227009006 Ligand Binding Site [chemical binding]; other site 526227009007 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526227009008 Ligand Binding Site [chemical binding]; other site 526227009009 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526227009010 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526227009011 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 526227009012 MPT binding site; other site 526227009013 trimer interface [polypeptide binding]; other site 526227009014 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227009015 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227009016 DNA binding site [nucleotide binding] 526227009017 domain linker motif; other site 526227009018 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227009019 dimerization interface [polypeptide binding]; other site 526227009020 ligand binding site [chemical binding]; other site 526227009021 alpha-galactosidase; Provisional; Region: PRK15076 526227009022 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 526227009023 NAD binding site [chemical binding]; other site 526227009024 sugar binding site [chemical binding]; other site 526227009025 divalent metal binding site [ion binding]; other site 526227009026 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227009027 dimer interface [polypeptide binding]; other site 526227009028 putative transposase OrfB; Reviewed; Region: PHA02517 526227009029 Integrase core domain; Region: rve; pfam00665 526227009030 Integrase core domain; Region: rve_3; pfam13683 526227009031 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 526227009032 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227009033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227009034 homodimer interface [polypeptide binding]; other site 526227009035 catalytic residue [active] 526227009036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526227009037 putative substrate translocation pore; other site 526227009038 D-galactonate transporter; Region: 2A0114; TIGR00893 526227009039 HicB family; Region: HicB; pfam05534 526227009040 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 526227009041 putative active site [active] 526227009042 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 526227009043 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 526227009044 tetramer interface [polypeptide binding]; other site 526227009045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227009046 catalytic residue [active] 526227009047 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 526227009048 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 526227009049 active site 526227009050 catalytic site [active] 526227009051 metal binding site [ion binding]; metal-binding site 526227009052 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 526227009053 Helix-hairpin-helix motif; Region: HHH; pfam00633 526227009054 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 526227009055 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 526227009056 Competence protein; Region: Competence; pfam03772 526227009057 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 526227009058 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526227009059 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 526227009060 ParB-like nuclease domain; Region: ParB; smart00470 526227009061 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 526227009062 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227009063 P-loop; other site 526227009064 Magnesium ion binding site [ion binding]; other site 526227009065 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227009066 Magnesium ion binding site [ion binding]; other site 526227009067 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 526227009068 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 526227009069 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 526227009070 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 526227009071 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 526227009072 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227009073 active site residue [active] 526227009074 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 526227009075 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 526227009076 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526227009077 Moco binding site; other site 526227009078 metal coordination site [ion binding]; other site 526227009079 Cytochrome c; Region: Cytochrom_C; pfam00034 526227009080 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 526227009081 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 526227009082 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526227009083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227009084 binding surface 526227009085 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227009086 TPR motif; other site 526227009087 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227009088 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 526227009089 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 526227009090 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227009091 active site 526227009092 catalytic residues [active] 526227009093 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 526227009094 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227009095 dimerization interface [polypeptide binding]; other site 526227009096 putative DNA binding site [nucleotide binding]; other site 526227009097 putative Zn2+ binding site [ion binding]; other site 526227009098 hydrogenase 4 subunit B; Validated; Region: PRK06521 526227009099 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526227009100 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 526227009101 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 526227009102 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526227009103 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 526227009104 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 526227009105 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 526227009106 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 526227009107 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 526227009108 putative active site [active] 526227009109 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227009110 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227009111 DNA binding site [nucleotide binding] 526227009112 domain linker motif; other site 526227009113 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227009114 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227009115 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526227009116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009117 dimer interface [polypeptide binding]; other site 526227009118 conserved gate region; other site 526227009119 putative PBP binding loops; other site 526227009120 ABC-ATPase subunit interface; other site 526227009121 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227009122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009123 dimer interface [polypeptide binding]; other site 526227009124 conserved gate region; other site 526227009125 putative PBP binding loops; other site 526227009126 ABC-ATPase subunit interface; other site 526227009127 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 526227009128 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 526227009129 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 526227009130 dimer interface [polypeptide binding]; other site 526227009131 putative radical transfer pathway; other site 526227009132 diiron center [ion binding]; other site 526227009133 tyrosyl radical; other site 526227009134 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 526227009135 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 526227009136 Class I ribonucleotide reductase; Region: RNR_I; cd01679 526227009137 active site 526227009138 dimer interface [polypeptide binding]; other site 526227009139 catalytic residues [active] 526227009140 effector binding site; other site 526227009141 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 526227009142 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 526227009143 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009144 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009145 GAF domain; Region: GAF; cl17456 526227009146 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227009147 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227009148 metal binding site [ion binding]; metal-binding site 526227009149 active site 526227009150 I-site; other site 526227009151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 526227009152 Transposase; Region: HTH_Tnp_1; pfam01527 526227009153 putative transposase OrfB; Reviewed; Region: PHA02517 526227009154 Integrase core domain; Region: rve; pfam00665 526227009155 Integrase core domain; Region: rve_3; pfam13683 526227009156 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526227009157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009158 dimer interface [polypeptide binding]; other site 526227009159 conserved gate region; other site 526227009160 ABC-ATPase subunit interface; other site 526227009161 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 526227009162 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 526227009163 Walker A/P-loop; other site 526227009164 ATP binding site [chemical binding]; other site 526227009165 Q-loop/lid; other site 526227009166 ABC transporter signature motif; other site 526227009167 Walker B; other site 526227009168 D-loop; other site 526227009169 H-loop/switch region; other site 526227009170 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 526227009171 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526227009172 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 526227009173 Walker A/P-loop; other site 526227009174 ATP binding site [chemical binding]; other site 526227009175 Q-loop/lid; other site 526227009176 ABC transporter signature motif; other site 526227009177 Walker B; other site 526227009178 D-loop; other site 526227009179 H-loop/switch region; other site 526227009180 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009181 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 526227009182 RES domain; Region: RES; cl02411 526227009183 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 526227009184 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 526227009185 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 526227009186 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 526227009187 intersubunit interface [polypeptide binding]; other site 526227009188 active site 526227009189 zinc binding site [ion binding]; other site 526227009190 Na+ binding site [ion binding]; other site 526227009191 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 526227009192 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 526227009193 substrate binding site [chemical binding]; other site 526227009194 hexamer interface [polypeptide binding]; other site 526227009195 metal binding site [ion binding]; metal-binding site 526227009196 phosphoribulokinase; Provisional; Region: PRK07429 526227009197 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 526227009198 active site 526227009199 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 526227009200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227009201 Walker A motif; other site 526227009202 ATP binding site [chemical binding]; other site 526227009203 Walker B motif; other site 526227009204 arginine finger; other site 526227009205 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 526227009206 multimerization interface [polypeptide binding]; other site 526227009207 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 526227009208 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 526227009209 homodimer interface [polypeptide binding]; other site 526227009210 active site 526227009211 heterodimer interface [polypeptide binding]; other site 526227009212 catalytic residue [active] 526227009213 metal binding site [ion binding]; metal-binding site 526227009214 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 526227009215 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 526227009216 putative active site [active] 526227009217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 526227009218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 526227009219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526227009220 dimerization interface [polypeptide binding]; other site 526227009221 DinB family; Region: DinB; cl17821 526227009222 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 526227009223 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 526227009224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526227009225 motif II; other site 526227009226 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 526227009227 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 526227009228 TPP-binding site [chemical binding]; other site 526227009229 dimer interface [polypeptide binding]; other site 526227009230 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 526227009231 PYR/PP interface [polypeptide binding]; other site 526227009232 dimer interface [polypeptide binding]; other site 526227009233 TPP binding site [chemical binding]; other site 526227009234 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526227009235 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 526227009236 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009237 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009238 PIN domain; Region: PIN_3; cl17397 526227009239 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526227009240 putative active site [active] 526227009241 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526227009242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227009243 DNA-binding site [nucleotide binding]; DNA binding site 526227009244 FCD domain; Region: FCD; cl11656 526227009245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 526227009246 Transposase; Region: HTH_Tnp_1; pfam01527 526227009247 putative transposase OrfB; Reviewed; Region: PHA02517 526227009248 Integrase core domain; Region: rve; pfam00665 526227009249 Integrase core domain; Region: rve_3; pfam13683 526227009250 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 526227009251 CoA-transferase family III; Region: CoA_transf_3; pfam02515 526227009252 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 526227009253 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 526227009254 Walker A/P-loop; other site 526227009255 ATP binding site [chemical binding]; other site 526227009256 Q-loop/lid; other site 526227009257 ABC transporter signature motif; other site 526227009258 Walker B; other site 526227009259 D-loop; other site 526227009260 H-loop/switch region; other site 526227009261 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 526227009262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227009263 dimer interface [polypeptide binding]; other site 526227009264 conserved gate region; other site 526227009265 ABC-ATPase subunit interface; other site 526227009266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 526227009267 NMT1/THI5 like; Region: NMT1; pfam09084 526227009268 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 526227009269 active site 526227009270 catalytic residues [active] 526227009271 metal binding site [ion binding]; metal-binding site 526227009272 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526227009273 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 526227009274 Transposase domain (DUF772); Region: DUF772; pfam05598 526227009275 Amidohydrolase; Region: Amidohydro_2; pfam04909 526227009276 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 526227009277 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 526227009278 N-formylglutamate amidohydrolase; Region: FGase; cl01522 526227009279 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 526227009280 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 526227009281 AsnC family; Region: AsnC_trans_reg; pfam01037 526227009282 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009283 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009284 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526227009285 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 526227009286 Walker A/P-loop; other site 526227009287 ATP binding site [chemical binding]; other site 526227009288 Q-loop/lid; other site 526227009289 ABC transporter signature motif; other site 526227009290 Walker B; other site 526227009291 D-loop; other site 526227009292 H-loop/switch region; other site 526227009293 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526227009294 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 526227009295 Walker A/P-loop; other site 526227009296 ATP binding site [chemical binding]; other site 526227009297 Q-loop/lid; other site 526227009298 ABC transporter signature motif; other site 526227009299 Walker B; other site 526227009300 D-loop; other site 526227009301 H-loop/switch region; other site 526227009302 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526227009303 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526227009304 TM-ABC transporter signature motif; other site 526227009305 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 526227009306 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526227009307 TM-ABC transporter signature motif; other site 526227009308 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 526227009309 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 526227009310 putative ligand binding site [chemical binding]; other site 526227009311 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 526227009312 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 526227009313 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 526227009314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526227009315 DNA-binding site [nucleotide binding]; DNA binding site 526227009316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227009317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227009318 homodimer interface [polypeptide binding]; other site 526227009319 catalytic residue [active] 526227009320 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 526227009321 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 526227009322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526227009323 short chain dehydrogenase; Provisional; Region: PRK06057 526227009324 NAD(P) binding site [chemical binding]; other site 526227009325 active site 526227009326 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526227009327 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 526227009328 NAD(P) binding site [chemical binding]; other site 526227009329 catalytic residues [active] 526227009330 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 526227009331 GAF domain; Region: GAF_3; pfam13492 526227009332 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526227009333 GAF domain; Region: GAF; cl17456 526227009334 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227009335 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227009336 metal binding site [ion binding]; metal-binding site 526227009337 active site 526227009338 I-site; other site 526227009339 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526227009340 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 526227009341 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 526227009342 Walker A/P-loop; other site 526227009343 ATP binding site [chemical binding]; other site 526227009344 Q-loop/lid; other site 526227009345 ABC transporter signature motif; other site 526227009346 Walker B; other site 526227009347 D-loop; other site 526227009348 H-loop/switch region; other site 526227009349 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 526227009350 Alkaline phosphatase homologues; Region: alkPPc; smart00098 526227009351 active site 526227009352 dimer interface [polypeptide binding]; other site 526227009353 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 526227009354 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 526227009355 homodimer interface [polypeptide binding]; other site 526227009356 substrate-cofactor binding pocket; other site 526227009357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227009358 catalytic residue [active] 526227009359 sulfite reductase subunit beta; Provisional; Region: PRK13504 526227009360 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 526227009361 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 526227009362 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 526227009363 active site 526227009364 SAM binding site [chemical binding]; other site 526227009365 homodimer interface [polypeptide binding]; other site 526227009366 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 526227009367 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 526227009368 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 526227009369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227009370 Walker A/P-loop; other site 526227009371 ATP binding site [chemical binding]; other site 526227009372 Q-loop/lid; other site 526227009373 ABC transporter signature motif; other site 526227009374 Walker B; other site 526227009375 D-loop; other site 526227009376 H-loop/switch region; other site 526227009377 TOBE-like domain; Region: TOBE_3; pfam12857 526227009378 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 526227009379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009380 dimer interface [polypeptide binding]; other site 526227009381 conserved gate region; other site 526227009382 putative PBP binding loops; other site 526227009383 ABC-ATPase subunit interface; other site 526227009384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009385 dimer interface [polypeptide binding]; other site 526227009386 conserved gate region; other site 526227009387 putative PBP binding loops; other site 526227009388 ABC-ATPase subunit interface; other site 526227009389 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 526227009390 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 526227009391 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 526227009392 ATP-sulfurylase; Region: ATPS; cd00517 526227009393 active site 526227009394 HXXH motif; other site 526227009395 flexible loop; other site 526227009396 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 526227009397 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 526227009398 Active Sites [active] 526227009399 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 526227009400 ligand-binding site [chemical binding]; other site 526227009401 Shikimate kinase; Region: SKI; pfam01202 526227009402 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526227009403 MarR family; Region: MarR; pfam01047 526227009404 Predicted membrane protein [Function unknown]; Region: COG1511 526227009405 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 526227009406 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 526227009407 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 526227009408 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 526227009409 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 526227009410 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 526227009411 putative di-iron ligands [ion binding]; other site 526227009412 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 526227009413 putative active site [active] 526227009414 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526227009415 putative transposase OrfB; Reviewed; Region: PHA02517 526227009416 Integrase core domain; Region: rve; pfam00665 526227009417 Integrase core domain; Region: rve_3; pfam13683 526227009418 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227009419 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 526227009420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009421 dimer interface [polypeptide binding]; other site 526227009422 conserved gate region; other site 526227009423 putative PBP binding loops; other site 526227009424 ABC-ATPase subunit interface; other site 526227009425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009426 dimer interface [polypeptide binding]; other site 526227009427 conserved gate region; other site 526227009428 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526227009429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526227009430 Walker A/P-loop; other site 526227009431 ATP binding site [chemical binding]; other site 526227009432 Q-loop/lid; other site 526227009433 ABC transporter signature motif; other site 526227009434 Walker B; other site 526227009435 D-loop; other site 526227009436 H-loop/switch region; other site 526227009437 TOBE domain; Region: TOBE_2; pfam08402 526227009438 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227009439 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 526227009440 Probable transposase; Region: OrfB_IS605; pfam01385 526227009441 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227009442 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526227009443 MULE transposase domain; Region: MULE; pfam10551 526227009444 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227009445 active site 526227009446 catalytic residues [active] 526227009447 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 526227009448 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 526227009449 putative NAD(P) binding site [chemical binding]; other site 526227009450 putative active site [active] 526227009451 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 526227009452 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 526227009453 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 526227009454 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 526227009455 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 526227009456 Ligand Binding Site [chemical binding]; other site 526227009457 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 526227009458 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 526227009459 Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819 526227009460 putative trimer interface [polypeptide binding]; other site 526227009461 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 526227009462 Replication initiator protein A; Region: RPA; cl17860 526227009463 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 526227009464 Part of AAA domain; Region: AAA_19; pfam13245 526227009465 Family description; Region: UvrD_C_2; pfam13538 526227009466 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227009467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227009468 ATP binding site [chemical binding]; other site 526227009469 putative Mg++ binding site [ion binding]; other site 526227009470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227009471 ATP-binding site [chemical binding]; other site 526227009472 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 526227009473 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227009474 ATP binding site [chemical binding]; other site 526227009475 putative Mg++ binding site [ion binding]; other site 526227009476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227009477 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 526227009478 nucleotide binding region [chemical binding]; other site 526227009479 ATP-binding site [chemical binding]; other site 526227009480 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 526227009481 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009482 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009483 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 526227009484 Tubulin like; Region: Tubulin_2; pfam13809 526227009485 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227009486 metal ion-dependent adhesion site (MIDAS); other site 526227009487 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009488 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009489 HTH domain; Region: HTH_11; pfam08279 526227009490 WYL domain; Region: WYL; pfam13280 526227009491 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 526227009492 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 526227009493 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 526227009494 active site 526227009495 substrate binding site [chemical binding]; other site 526227009496 catalytic site [active] 526227009497 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 526227009498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227009499 ATP binding site [chemical binding]; other site 526227009500 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 526227009501 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227009502 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227009503 ATP binding site [chemical binding]; other site 526227009504 putative Mg++ binding site [ion binding]; other site 526227009505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227009506 nucleotide binding region [chemical binding]; other site 526227009507 ATP-binding site [chemical binding]; other site 526227009508 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 526227009509 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526227009510 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 526227009511 RNB domain; Region: RNB; pfam00773 526227009512 TROVE domain; Region: TROVE; pfam05731 526227009513 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227009514 metal ion-dependent adhesion site (MIDAS); other site 526227009515 putative transposase OrfB; Reviewed; Region: PHA02517 526227009516 Integrase core domain; Region: rve; pfam00665 526227009517 Integrase core domain; Region: rve_3; pfam13683 526227009518 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 526227009519 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 526227009520 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 526227009521 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742 526227009522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 526227009523 Transposase; Region: HTH_Tnp_1; pfam01527 526227009524 putative transposase OrfB; Reviewed; Region: PHA02517 526227009525 Integrase core domain; Region: rve; pfam00665 526227009526 Integrase core domain; Region: rve_3; pfam13683 526227009527 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 526227009528 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 526227009529 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 526227009530 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 526227009531 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 526227009532 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 526227009533 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 526227009534 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 526227009535 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 526227009536 CRISPR-associated protein; Region: DUF3692; pfam12469 526227009537 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 526227009538 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 526227009539 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 526227009540 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 526227009541 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 526227009542 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 526227009543 Predicted transcriptional regulator [Transcription]; Region: COG2378 526227009544 WYL domain; Region: WYL; pfam13280 526227009545 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 526227009546 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 526227009547 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 526227009548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 526227009549 TPR motif; other site 526227009550 binding surface 526227009551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 526227009552 DNA binding site [nucleotide binding] 526227009553 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227009554 P-loop; other site 526227009555 AAA domain; Region: AAA_31; pfam13614 526227009556 Magnesium ion binding site [ion binding]; other site 526227009557 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227009558 Magnesium ion binding site [ion binding]; other site 526227009559 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 526227009560 ParB-like nuclease domain; Region: ParB; smart00470 526227009561 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227009562 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227009563 DNA binding site [nucleotide binding] 526227009564 domain linker motif; other site 526227009565 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526227009566 ligand binding site [chemical binding]; other site 526227009567 dimerization interface [polypeptide binding]; other site 526227009568 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 526227009569 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227009570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009571 dimer interface [polypeptide binding]; other site 526227009572 conserved gate region; other site 526227009573 putative PBP binding loops; other site 526227009574 ABC-ATPase subunit interface; other site 526227009575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009576 dimer interface [polypeptide binding]; other site 526227009577 conserved gate region; other site 526227009578 putative PBP binding loops; other site 526227009579 ABC-ATPase subunit interface; other site 526227009580 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526227009581 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526227009582 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 526227009583 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 526227009584 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 526227009585 substrate binding pocket [chemical binding]; other site 526227009586 membrane-bound complex binding site; other site 526227009587 hinge residues; other site 526227009588 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 526227009589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 526227009590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009591 putative PBP binding loops; other site 526227009592 dimer interface [polypeptide binding]; other site 526227009593 ABC-ATPase subunit interface; other site 526227009594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009595 dimer interface [polypeptide binding]; other site 526227009596 conserved gate region; other site 526227009597 ABC-ATPase subunit interface; other site 526227009598 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 526227009599 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 526227009600 Walker A/P-loop; other site 526227009601 ATP binding site [chemical binding]; other site 526227009602 Q-loop/lid; other site 526227009603 ABC transporter signature motif; other site 526227009604 Walker B; other site 526227009605 D-loop; other site 526227009606 H-loop/switch region; other site 526227009607 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009608 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009609 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 526227009610 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526227009611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227009612 homodimer interface [polypeptide binding]; other site 526227009613 catalytic residue [active] 526227009614 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526227009615 catalytic core [active] 526227009616 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 526227009617 homotrimer interface [polypeptide binding]; other site 526227009618 Walker A motif; other site 526227009619 GTP binding site [chemical binding]; other site 526227009620 Walker B motif; other site 526227009621 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 526227009622 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 526227009623 putative dimer interface [polypeptide binding]; other site 526227009624 active site pocket [active] 526227009625 putative cataytic base [active] 526227009626 cobalamin synthase; Reviewed; Region: cobS; PRK00235 526227009627 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227009628 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227009629 metal binding site [ion binding]; metal-binding site 526227009630 active site 526227009631 I-site; other site 526227009632 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 526227009633 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 526227009634 Lagovirus protein of unknown function (DUF840); Region: DUF840; pfam05801 526227009635 GAF domain; Region: GAF_3; pfam13492 526227009636 GAF domain; Region: GAF; cl17456 526227009637 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526227009638 Zn2+ binding site [ion binding]; other site 526227009639 Mg2+ binding site [ion binding]; other site 526227009640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 526227009641 Transposase; Region: HTH_Tnp_1; pfam01527 526227009642 putative transposase OrfB; Reviewed; Region: PHA02517 526227009643 Integrase core domain; Region: rve; pfam00665 526227009644 Integrase core domain; Region: rve_3; pfam13683 526227009645 GAF domain; Region: GAF; cl17456 526227009646 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227009647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227009648 metal binding site [ion binding]; metal-binding site 526227009649 active site 526227009650 I-site; other site 526227009651 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009652 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009653 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 526227009654 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 526227009655 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 526227009656 Class I ribonucleotide reductase; Region: RNR_I; cd01679 526227009657 active site 526227009658 dimer interface [polypeptide binding]; other site 526227009659 catalytic residues [active] 526227009660 effector binding site; other site 526227009661 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 526227009662 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 526227009663 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 526227009664 dimer interface [polypeptide binding]; other site 526227009665 putative radical transfer pathway; other site 526227009666 diiron center [ion binding]; other site 526227009667 tyrosyl radical; other site 526227009668 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 526227009669 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 526227009670 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 526227009671 active site 526227009672 homodimer interface [polypeptide binding]; other site 526227009673 catalytic site [active] 526227009674 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 526227009675 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526227009676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009677 dimer interface [polypeptide binding]; other site 526227009678 conserved gate region; other site 526227009679 putative PBP binding loops; other site 526227009680 ABC-ATPase subunit interface; other site 526227009681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009682 dimer interface [polypeptide binding]; other site 526227009683 conserved gate region; other site 526227009684 putative PBP binding loops; other site 526227009685 ABC-ATPase subunit interface; other site 526227009686 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526227009687 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526227009688 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526227009689 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526227009690 DNA binding site [nucleotide binding] 526227009691 domain linker motif; other site 526227009692 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526227009693 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 526227009694 putative active site [active] 526227009695 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 526227009696 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 526227009697 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 526227009698 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 526227009699 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526227009700 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 526227009701 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 526227009702 hydrogenase 4 subunit B; Validated; Region: PRK06521 526227009703 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526227009704 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227009705 dimerization interface [polypeptide binding]; other site 526227009706 putative DNA binding site [nucleotide binding]; other site 526227009707 putative Zn2+ binding site [ion binding]; other site 526227009708 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 526227009709 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 526227009710 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526227009711 active site 526227009712 catalytic residues [active] 526227009713 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 526227009714 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526227009715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526227009716 binding surface 526227009717 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227009718 TPR motif; other site 526227009719 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227009720 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 526227009721 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 526227009722 Cytochrome c; Region: Cytochrom_C; pfam00034 526227009723 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526227009724 Moco binding site; other site 526227009725 metal coordination site [ion binding]; other site 526227009726 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 526227009727 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 526227009728 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227009729 active site residue [active] 526227009730 Cytochrome c [Energy production and conversion]; Region: COG3258 526227009731 Cytochrome c; Region: Cytochrom_C; cl11414 526227009732 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 526227009733 active site 526227009734 metal binding site [ion binding]; metal-binding site 526227009735 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 526227009736 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 526227009737 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 526227009738 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 526227009739 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 526227009740 Predicted secreted protein [Function unknown]; Region: COG5501 526227009741 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 526227009742 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 526227009743 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 526227009744 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 526227009745 catalytic residues [active] 526227009746 Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577 526227009747 Dodecin; Region: Dodecin; pfam07311 526227009748 Protein of unknown function (DUF981); Region: DUF981; pfam06168 526227009749 Predicted membrane protein [Function unknown]; Region: COG3374 526227009750 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 526227009751 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 526227009752 catalytic motif [active] 526227009753 Zn binding site [ion binding]; other site 526227009754 RibD C-terminal domain; Region: RibD_C; cl17279 526227009755 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 526227009756 Lumazine binding domain; Region: Lum_binding; pfam00677 526227009757 Lumazine binding domain; Region: Lum_binding; pfam00677 526227009758 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 526227009759 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 526227009760 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 526227009761 dimerization interface [polypeptide binding]; other site 526227009762 active site 526227009763 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 526227009764 homopentamer interface [polypeptide binding]; other site 526227009765 active site 526227009766 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227009767 dimerization interface [polypeptide binding]; other site 526227009768 putative DNA binding site [nucleotide binding]; other site 526227009769 putative Zn2+ binding site [ion binding]; other site 526227009770 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526227009771 active site residue [active] 526227009772 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 526227009773 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 526227009774 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526227009775 Zn binding site [ion binding]; other site 526227009776 Cytochrome c; Region: Cytochrom_C; pfam00034 526227009777 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 526227009778 oligomer interface [polypeptide binding]; other site 526227009779 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 526227009780 hydrophobic ligand binding site; other site 526227009781 GYD domain; Region: GYD; pfam08734 526227009782 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526227009783 Predicted ATPase [General function prediction only]; Region: COG3903 526227009784 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227009785 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227009786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 526227009787 binding surface 526227009788 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526227009789 TPR motif; other site 526227009790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227009791 Walker A motif; other site 526227009792 ATP binding site [chemical binding]; other site 526227009793 Walker B motif; other site 526227009794 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 526227009795 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526227009796 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 526227009797 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009798 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 526227009799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526227009800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526227009801 active site 526227009802 phosphorylation site [posttranslational modification] 526227009803 intermolecular recognition site; other site 526227009804 dimerization interface [polypeptide binding]; other site 526227009805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526227009806 DNA binding residues [nucleotide binding] 526227009807 dimerization interface [polypeptide binding]; other site 526227009808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526227009809 ATP binding site [chemical binding]; other site 526227009810 Mg2+ binding site [ion binding]; other site 526227009811 G-X-G motif; other site 526227009812 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 526227009813 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 526227009814 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526227009815 Soluble P-type ATPase [General function prediction only]; Region: COG4087 526227009816 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 526227009817 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 526227009818 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 526227009819 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 526227009820 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 526227009821 Ligand Binding Site [chemical binding]; other site 526227009822 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 526227009823 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 526227009824 Walker A/P-loop; other site 526227009825 ATP binding site [chemical binding]; other site 526227009826 Q-loop/lid; other site 526227009827 ABC transporter signature motif; other site 526227009828 Walker B; other site 526227009829 D-loop; other site 526227009830 H-loop/switch region; other site 526227009831 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 526227009832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009833 dimer interface [polypeptide binding]; other site 526227009834 conserved gate region; other site 526227009835 putative PBP binding loops; other site 526227009836 ABC-ATPase subunit interface; other site 526227009837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526227009838 dimer interface [polypeptide binding]; other site 526227009839 conserved gate region; other site 526227009840 putative PBP binding loops; other site 526227009841 ABC-ATPase subunit interface; other site 526227009842 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 526227009843 Helix-hairpin-helix motif; Region: HHH; pfam00633 526227009844 DdrB-like protein; Region: DdrB; pfam12747 526227009845 putative transposase OrfB; Reviewed; Region: PHA02517 526227009846 Integrase core domain; Region: rve; pfam00665 526227009847 Integrase core domain; Region: rve_3; pfam13683 526227009848 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 526227009849 putative active site [active] 526227009850 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 526227009851 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 526227009852 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 526227009853 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 526227009854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526227009855 dimerization interface [polypeptide binding]; other site 526227009856 putative DNA binding site [nucleotide binding]; other site 526227009857 Predicted transcriptional regulator [Transcription]; Region: COG2378 526227009858 putative Zn2+ binding site [ion binding]; other site 526227009859 WYL domain; Region: WYL; pfam13280 526227009860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 526227009861 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 526227009862 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 526227009863 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 526227009864 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 526227009865 putative transposase OrfB; Reviewed; Region: PHA02517 526227009866 Integrase core domain; Region: rve; pfam00665 526227009867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 526227009868 Transposase; Region: HTH_Tnp_1; pfam01527 526227009869 putative transposase OrfB; Reviewed; Region: PHA02517 526227009870 Integrase core domain; Region: rve; pfam00665 526227009871 Integrase core domain; Region: rve_3; pfam13683 526227009872 putative transposase OrfB; Reviewed; Region: PHA02517 526227009873 Integrase core domain; Region: rve; pfam00665 526227009874 Integrase core domain; Region: rve_3; pfam13683 526227009875 Protein of unknown function (DUF433); Region: DUF433; pfam04255 526227009876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 526227009877 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 526227009878 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 526227009879 homodimer interface [polypeptide binding]; other site 526227009880 substrate-cofactor binding pocket; other site 526227009881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526227009882 catalytic residue [active] 526227009883 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 526227009884 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 526227009885 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 526227009886 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 526227009887 Glutamine amidotransferase class-I; Region: GATase; pfam00117 526227009888 glutamine binding [chemical binding]; other site 526227009889 catalytic triad [active] 526227009890 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 526227009891 active site 526227009892 catalytic residues [active] 526227009893 Int/Topo IB signature motif; other site 526227009894 DNA binding site [nucleotide binding] 526227009895 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526227009896 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526227009897 TAP-like protein; Region: Abhydrolase_4; pfam08386 526227009898 CRISPR/Cas system-associated protein Csx16; Region: Csx16_III-U; cl09866 526227009899 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 526227009900 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 526227009901 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 526227009902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227009903 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 526227009904 Probable transposase; Region: OrfB_IS605; pfam01385 526227009905 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227009906 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 526227009907 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 526227009908 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 526227009909 RNA/DNA hybrid binding site [nucleotide binding]; other site 526227009910 active site 526227009911 ParB-like nuclease domain; Region: ParBc; cl02129 526227009912 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 526227009913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526227009914 non-specific DNA binding site [nucleotide binding]; other site 526227009915 salt bridge; other site 526227009916 sequence-specific DNA binding site [nucleotide binding]; other site 526227009917 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 526227009918 ParB-like nuclease domain; Region: ParB; smart00470 526227009919 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 526227009920 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526227009921 metal ion-dependent adhesion site (MIDAS); other site 526227009922 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 526227009923 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227009924 ssDNA binding site [nucleotide binding]; other site 526227009925 dimer interface [polypeptide binding]; other site 526227009926 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227009927 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 526227009928 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526227009929 dimer interface [polypeptide binding]; other site 526227009930 ssDNA binding site [nucleotide binding]; other site 526227009931 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526227009932 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 526227009933 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009934 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 526227009935 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 526227009936 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 526227009937 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526227009938 catalytic residue [active] 526227009939 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526227009940 GAF domain; Region: GAF_3; pfam13492 526227009941 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526227009942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526227009943 metal binding site [ion binding]; metal-binding site 526227009944 active site 526227009945 I-site; other site 526227009946 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526227009947 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 526227009948 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526227009949 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 526227009950 Part of AAA domain; Region: AAA_19; pfam13245 526227009951 Family description; Region: UvrD_C_2; pfam13538 526227009952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227009953 Probable transposase; Region: OrfB_IS605; pfam01385 526227009954 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227009955 Transposase IS200 like; Region: Y1_Tnp; pfam01797 526227009956 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 526227009957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227009958 Walker A motif; other site 526227009959 ATP binding site [chemical binding]; other site 526227009960 Walker B motif; other site 526227009961 Thioredoxin; Region: Thioredoxin_4; cl17273 526227009962 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 526227009963 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 526227009964 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 526227009965 Walker A motif; other site 526227009966 ATP binding site [chemical binding]; other site 526227009967 Walker B motif; other site 526227009968 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 526227009969 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 526227009970 Walker A motif; other site 526227009971 ATP binding site [chemical binding]; other site 526227009972 Walker B motif; other site 526227009973 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 526227009974 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 526227009975 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 526227009976 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 526227009977 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 526227009978 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 526227009979 replicative DNA helicase; Region: DnaB; TIGR00665 526227009980 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 526227009981 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 526227009982 Walker A motif; other site 526227009983 ATP binding site [chemical binding]; other site 526227009984 Walker B motif; other site 526227009985 DNA binding loops [nucleotide binding] 526227009986 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 526227009987 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 526227009988 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 526227009989 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 526227009990 NlpC/P60 family; Region: NLPC_P60; pfam00877 526227009991 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 526227009992 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 526227009993 CRISPR/Cas system-associated protein Csx16; Region: Csx16_III-U; cl09866 526227009994 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 526227009995 Walker A motif; other site 526227009996 ATP binding site [chemical binding]; other site 526227009997 Walker B motif; other site 526227009998 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 526227009999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526227010000 Walker A motif; other site 526227010001 ATP binding site [chemical binding]; other site 526227010002 Walker B motif; other site 526227010003 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 526227010004 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 526227010005 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 526227010006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 526227010007 Probable transposase; Region: OrfB_IS605; pfam01385 526227010008 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 526227010009 diaminopimelate epimerase; Region: DapF; TIGR00652 526227010010 AAA-like domain; Region: AAA_10; pfam12846 526227010011 Domain of unknown function DUF87; Region: DUF87; pfam01935 526227010012 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 526227010013 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 526227010014 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 526227010015 active site 526227010016 catalytic residues [active] 526227010017 Int/Topo IB signature motif; other site 526227010018 DNA binding site [nucleotide binding] 526227010019 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 526227010020 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227010021 ATP binding site [chemical binding]; other site 526227010022 putative Mg++ binding site [ion binding]; other site 526227010023 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227010024 nucleotide binding region [chemical binding]; other site 526227010025 ATP-binding site [chemical binding]; other site 526227010026 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 526227010027 PLD-like domain; Region: PLDc_2; pfam13091 526227010028 putative homodimer interface [polypeptide binding]; other site 526227010029 putative active site [active] 526227010030 catalytic site [active] 526227010031 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526227010032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526227010033 ATP binding site [chemical binding]; other site 526227010034 putative Mg++ binding site [ion binding]; other site 526227010035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526227010036 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 526227010037 nucleotide binding region [chemical binding]; other site 526227010038 ATP-binding site [chemical binding]; other site 526227010039 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 526227010040 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 526227010041 S-layer homology domain; Region: SLH; pfam00395 526227010042 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 526227010043 AAA domain; Region: AAA_30; pfam13604 526227010044 Family description; Region: UvrD_C_2; pfam13538 526227010045 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 526227010046 YcfA-like protein; Region: YcfA; pfam07927 526227010047 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 526227010048 non-specific DNA binding site [nucleotide binding]; other site 526227010049 salt bridge; other site 526227010050 sequence-specific DNA binding site [nucleotide binding]; other site 526227010051 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 526227010052 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227010053 P-loop; other site 526227010054 Magnesium ion binding site [ion binding]; other site 526227010055 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526227010056 Magnesium ion binding site [ion binding]; other site 526227010057 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 526227010058 ParB-like nuclease domain; Region: ParBc; pfam02195